Dissertations / Theses: 'Raynaud's'

1

Gardner-Medwin, Janet. "The endothelium in primary Raynaud's phenomenon." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360542.

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Roustit, Matthieu. "Etude de la fonction microvasculaire cutanée dans le syndrome de Raynaud : approches physiopathologique et pharmacologique." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00633855.

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La microcirculation cutanée a été proposée comme modèle d'étude de la dysfonction microvasculaire globale dans les maladies cardiovasculaires. Par ailleurs, elle est spécifiquement atteinte dans le syndrome de Raynaud, qui est une ischémie paroxystique des extrémités déclenchée notamment par le froid. L'exploration de la fonction microvasculaire cutanée suscite donc un réel intérêt, mais les méthodes d'étude souffrent d'une hétérogénéité importante, et leur variabilité intra-individuelle est mal connue. La première partie de ce travail fait la synthèse des différentes méthodes d'étude la fonction microvasculaire cutanée, et rapporte les résultats de deux études consacrées à leur reproductibilité. Nous avons dans une seconde partie étudié grâce à ces tests la réactivité microvasculaire cutanée dans le syndrome de Raynaud, et mis en évidence des anomalies chez ces patients, notamment du contrôle neuro-vasculaire. La dernière partie de cette thèse est consacrée à l'étude d'approches pharmacologiques ciblées sur les anomalies de la microcirculation cutanée identifiées chez les patients. Nous avons évalué l'effet du sildenafil, un inhibiteur de la phosphodiesterase-5, sur le flux sanguin digital et montré son effet vasodilatateur lors d'un refroidissement local dans le syndrome de Raynaud. Enfin, nous avons étudiés chez l'animal et chez l'homme l'iontophorèse de vasodilatateurs, une approche innovante d'administration locale de médicaments pour augmenter le flux sanguin cutané.

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3

Smyth, Anita Elizabeth. "The vascular genetics of primary Raynaud's phenomenon." Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268176.

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Najarian, B. "Psychological and physiological aspects of Raynaud's Phenomenon." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234981.

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YAMADA, SHIN'YA, HISATAKA SAKAKIBARA, NOBUHIDE ISHIKAWA, and NORIKUNI TOIBANA. "RAYNAUD'S PHENOMENON OF FINGERS AND TOES AMONG VIBRATION-EXPOSED PATIENTS." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/16060.

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6

Palmer, Keith. "Aspects of human health and occupational exposure to vibration." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312305.

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7

Khouri, Charles. "Pharmacologie de la microcirculation : phénomène de Raynaud, troubles trophiques cutanés et hypertension artérielle pulmonaire Drug‐induced Raynaud's phenomenon: beyond β‐adrenoceptor blockers Peripheral vasoconstriction induced by β‐adrenoceptor blockers: a systematic review and a network meta‐analysis Fluoxetine and Raynaud's phenomenon: friend or foe? Proton pump inhibitors and Raynaud’s phenomenon: is there a link?" Thesis, Université Grenoble Alpes (ComUE), 2019. https://thares.univ-grenoble-alpes.fr/2019GREAS028.pdf.

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La microcirculation désigne le sous-ensemble du système circulatoire où s'effectuent les échanges gazeux et liquidiens extracellulaires. Elle est composée des artérioles, des capillaires et des veinules. Plusieurs pathologies sont induites par une atteinte structurelle et/ou fonctionnelle primaire de cette microcirculation : le phénomène de Raynaud (PR), les troubles trophiques vasculaires et l’hypertension artérielle pulmonaire (HTAP). Les objectifs de ce travail sont d’étudier, de comprendre et d’identifier de nouvelles étiologies iatrogènes à ces pathologies microvasculaires, ainsi que d’évaluer et de comparer l’efficacité et la sécurité des traitements utilisés dans ces pathologies. Nous avons, à cette fin, réalisé plusieurs études à partir des bases de données de pharmacovigilances, de données d’essais cliniques et de la littérature.Ce travail de thèse nous a permis d’explorer le rôle des médicaments dans ces pathologies microvasculaires, champs qui restait encore peu étudié dans la littérature. Ces travaux nous ont permis d’identifier de nombreuses classes pharmacologiques dont le rôle était encore non décrit dans ces pathologies. L’étude des mécanismes pharmacologiques à l’origine de ces effets indésirables permet également d’émettre de nouvelles hypothèses physiopathologiques à l’origine de ces maladies.Les traitements utilisés dans ces différentes pathologies microcirculatoires sont à l’heure actuelle encore peu spécifiques et des travaux de recherche important doivent encore être réalisés afin de personnaliser la prise en charge des patients
Microcirculation refers to the subset of the circulatory system where extracellular gas and fluid exchanges take place. It is composed of arterioles, capillaries and venules. Several pathologies are induced by a primary structural and/or functional impairment of this microcirculation: Raynaud's phenomenon (RP), trophic vascular disorders and pulmonary arterial hypertension (PAH). The objectives of this work are to study, understand and identify new iatrogenic etiologies to these microvascular diseases, as well as to evaluate and compare the effectiveness and safety of treatments used in these diseases. We therefore conducted several studies using pharmacovigilance databases, clinical trial data and the literature.This thesis work allowed us to explore the role of drugs in these microvascular pathologies, fields that were poorly studied in the literature yet. This work has allowed us to identify many pharmacological classes whose role was unknown in these diseases. The study of the pharmacological mechanisms underlying these adverse drug reactions also makes it possible to develop new pathophysiological hypotheses underlying these diseases.The treatments used in these different microvascular diseases are currently not specific and important research work still needs to be carried out in order to personalize patient care

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Pauling, John D. "Evaluating digital vascular perfusion and platelet dysfunction in Raynaud's phenomenon and systemic sclerosis." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606666.

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Raynaud’s phenomenon (RP) describes excessive vasoconstriction of the digital microvasculature in response to cold exposure and emotional stress. RP is typically the earliest clinical manifestation of systemic sclerosis (SSc); a complex multisystem disease of unknown aetiology characterized by vasculopathy, inflammation and fibrosis. Vasculopathy is considered an essential pre-requisite to tissue remodeling, characterized by excessive collagen synthesis and tissue fibrosis, which occurs in the skin and other organs of patients with SSc. There is mounting evidence associating platelets with important biological functions beyond primary haemostasis. Upon activation, platelets release a large array of mediators implicated in vasoconstriction, inflammation and fibrosis, which has led me to consider the contribution of platelets to the pathogenesis of both RP and SSc. The principal aim of this thesis is to explore the impact of targeted anti-thrombotic therapy on digital microvascular function, platelet activation, oxidative stress and eicosanoid biosynthesis in RP and SSc. It is not possible to examine the impact of anti-platelet therapy on microvascular function, without first identifying sensitive methods for assessing digital microvascular function in humans. I shall report the findings of work examining established (infrared thermography) and novel (laser speckle contrast imaging) methods for the objective assessment of digital microvascular function in RP and SSc. I shall critically appraise the application of these methods alongside subjective patient self-report assessment of digital vascular function. I shall examine associations between digital vascular function, platelet activation, oxidative stress and eicosanoid biosynthesis between primary RP and SSc. I shall also report the findings of an investigator-led early phase clinical trial of targeted anti-thrombotic medication in RP and SSc. The major findings of this study were highlighting the strengths and limitations of established and novel methods for objective microvascular assessment in RP and SSc, and the poor agreement that exists between objective and subjective methods for assessing RP severity. I have identified similarities and differences in platelet activation and eicosanoid biosynthesis in primary RP and SSc. I shall present evidence of apparent efficacy of asasantin retard therapy on subjective, but not objective, assessments of digital microvascular function; the relevance of which shall be discussed in detail.

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9

Wilks, Julia. "A behavioural approach to the management of the symptoms of Raynaud's Disease and phenomenon." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340528.

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Smith, Paula J. W. "An investigation into the pathogenesis of Raynaud's disease : the role of the vascular endothelium." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/20803.

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The aim of this thesis was to investigate the role of the vascular endothelium in the development of cold-induced vasoconstriction, and in the pathophysiology of vasospasm in RD. Experiments were performed on resistance arteries in vitro and in vivo. The small vessel arteriograph (perfusion myograph) was used to study isolated arteries in vitro. Studies in vivo used the autoperfused hindlimb of the anaesthetised rat, in which stepped-cooling of the blood entering the hindlimb produced a rise in hindlimb perfusion pressure. Possible mediators of this cold-induced vasoconstriction were identified using antagonists selective for α-adrenoceptors and ET-receptors. Inhibitors of NO-synthase and cyclooxygenase were also examined. The α₁/α₂-adrenoceptor antagonist, phentolamine, attenuated the cold-induced vasoconstriction, and was the only agent to have an effect that was significant in this model. The results demonstrate that the endothelium is an important modulator of cold-induced effects on the response to several vasoconstrictor agents, either by enhancing contraction through the release of vasoconstrictors such as ET, or by depressing contraction through the release of dilators, such as NO or PGI₂. The effects of cooling on the responsiveness of an artery appears to depend on the type of vessel under study (cutaneous versus non-cutaneous). The results from the gluteal biopsy studies imply that the altered sensitivity to ET-1 at 37^oC in RD patients is dependent on changes in dilator function, and not to altered sensitivity of the vascular smooth muscle to ET-1. Although an increase in the response to ET-1 was not found at 24^oC, the results obtained at 37^OC would support the hypothesis that the release and/or actions of NO is reduced in RD, allowing enhanced constriction of ET. These results suggest that the vascular endothelium is involved in the pathophysiology of RD.

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11

Smith, V., Vanessa Smith, Ariane L. Herrick, Francesca Ingegnoli, Nemanja Damjanov, Angelis Rossella De, Christopher P. Denton, et al. "Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis." Elsevier B.V, 2020. http://hdl.handle.net/10757/651734.

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Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progression, capillaroscopy became a ‘mainstream’ investigation for rheumatologists. Given its increasing use by a variety of physicians internationally both in daily practice to differentiate primary from secondary Raynaud's phenomenon, as well as in research context to predict disease progression and monitor treatment effects, standardisation in capillaroscopic image acquisition and analysis seems paramount. To step forward to this need, experts in the field of capillaroscopy/microcirculation provide in this very consensus paper their view on image acquisition and analysis, different capillaroscopic techniques, normal and abnormal capillaroscopic characteristics and their meaning, scoring systems and reliability of image acquisition and interpretation.
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IWATA, HIROTOSHI, SHINTARO TAKEDA, MOTOTSUGU KURODA, KUNIHIKO MIYAMOTO, and KAZUHISA MIYASHITA. "HAND-ARM VIBRATION EXPOSURE AND THE DEVELOPMENT OF VFFIRATION SYNDROME." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/16053.

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INABA, RYOICHI, HIROTOSHI IWATA, and S. MOHAMMAD MIRBOD. "OPERATING HAND-HELD VIBRATING TOOLS AND PREVALENCE OF WHITE FINGERS." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/16065.

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14

Pettersson, Hans. "Risk of hearing loss from combined exposure to hand-arm vibrations and noise." Doctoral thesis, Umeå universitet, Yrkes- och miljömedicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-64191.

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Hearing loss from noise exposure is one of the most common occupational injuries, and exposure to vibrations may increase the risk of noise-induced hearing loss. Earlier cross-sectional and longitudinal studies found an increased risk of noise-induced hearing loss among workers with vibration-induced white fingers (VWF) symptoms compared to workers without such symptoms. It has been suggested that vibrations to the hand stimulate the sympathetic nervous system and cause vasoconstriction in both the exposed hand and the ears and that this contributes to noise-induced hearing loss. The overall aim of this thesis was to examine how hand-arm vibrations (HAV) interact with noise in the development of noise-induced hearing loss. The experimental study in this thesis examined the effects of HAV and noise, both separately and combined, on the temporary threshold shift (TTS) in hearing in 22 healthy male and female subjects. The two longitudinal studies in this thesis were based on a cohort of 189 male workers at a heavy engineering workshop. The first cohort study examined the risk of noise-induced hearing loss from long-term exposure to HAV and noise. The second cohort study examined if workers with VWF had an increased risk of noise-induced hearing loss compared to workers without such symptoms. Finally, the questionnaire study in this thesis examined the occurrence of Raynaud’s phenomenon among 133 men and women with noise-induced hearing loss in relation to exposure to vibrations. In the experimental study, no differences in TTS in hearing were observed after combined exposure to HAV and noise compared to exposure to only noise. In the first cohort study, there was an increased risk of noise-induced hearing loss with increased exposure to HAV in a noisy environment. In the second cohort study, it was found that workers with VWF had an increased risk of noise-induced hearing loss compared to workers without VWF. In the questionnaire study, many men and women with noise-induced hearing loss had used hand-held vibrating machines suggesting that vibrations might contribute to noise-induced hearing loss. A high prevalence of Raynaud’s phenomenon was found among men. This thesis demonstrated that there was a long-term effect on noise-induced hearing loss from combined exposure to noise and HAV, but no short-term effect, and that having Raynaud’s phenomenon may also increase the risk of noise-induced hearing loss.
Många arbetare använder sig av handhållna vibrerande verktyg. Det utsätter dem för höga nivåer av både buller och vibrationer. Människor som utsätts för höga bullernivåer under lång tid kan skada sin hörsel. Risken för hörselnedsättning orsakad av buller kan eventuellt öka om personen samtidigt är utsatt för vibrationer från handhållna vibrerande verktyg. Syftet med avhandlingen var att studera om vibrationer i kombination med buller ökar risken för hörselnedsättning. Avhandlingen består av fyra studier. Den första studien är en experimentell studie med 22 friska deltagare med god hörsel. Denna studie undersökte hur hörseln tillfälligt påverkas av buller och vibrationer, separat och i kombination. Den andra och tredje studien bygger på en population bestående av 189 verkstadsarbetare i Sundsvall som följts regelbundet sedan 1987. Den andra studien undersökte om det finns en ökad risk för hörselnedsättning för arbetare som utsätts för buller och vibrationer under lång tid. Den tredje studien undersökte om arbetare med vita fingrar har en ökad risk för hörselnedsättning än arbetare utan vita fingrar. Vita fingrar är en kärlskada orsakad av vibrationer som gör att fingrarna reagerar onormalt snabbt på kyla. Fingrarna blir vita när blodtillförseln till dem stryps. Den fjärde studien är en enkätstudie med 342 kvinnor och män som har en bekräftad hörselnedsättning orsakad av buller. Studien undersökte hur många ur denna grupp som utsätts för vibrationer samt har vita fingrar. Resultaten från studierna visar att det inte finns någon skillnad i hörselpåverkan från buller och vibrationer i kombination jämfört med enbart buller under kort tid. De som utsätts för vibrationer från handhållna vibrerande verktyg i en bullrig miljö under lång tid har en ökad risk för hörselnedsättning. Arbetare med vita fingrar har en högre risk för hörselnedsättning än de utan. En hög andel av de med hörselnedsättning orsakad av buller använder sig av handhållna vibrerande verktyg. I studien fanns även en hög andel med vita fingrar. Sammanfattningsvis visar resultaten att det finns en långtidseffekt av buller och vibrationer på hörselnedsättning men inte någon korttidseffekt, och att vita fingrar kan påverka risken för hörselnedsättning.

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IKI, MASAYUKI. "VIBRATION-INDUCED WHITE FINGER AS A RISK FACTOR FOR HEARING LOSS AND POSTURAL INSTABILITY." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/16062.

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16

Lagerkvist, Birgitta Json. "Systemic effects of occupational exposure to arsenic : with special reference to peripheral circulation and nerve function." Doctoral thesis, Umeå universitet, Klinisk fysiologi, 1989. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101288.

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Smelter workers who were exposed to air-borne arsenic for a mean of 23 years, and age-matched referents, were examined with clinical, physiological, and neurophysiological methods. Exposure to arsenic in workroom air was estimated to have been around the Swedish occupational limits, which were 500 yg/m before 1975 and 50 yg/ra thereafter. An increased preval ence of Raynaud's phenomenon and a reduced finger systolic blood pressure (FSP) during local and general cooling were found in the smelter workers. Slight, but significant sub-clinical neuropathy, in the form of slightly reduced nerve conduction velocity (NCV) in two or more peripheral nerves, was more common among the arsenic workers than among the referents. There were positive correlations between cumulative exposure to arsenic, reduced NCV in three peripheral motor nerves, and decrease in FSP during cooling. Arsenic levels in urine were 1 ymole/1 (75 yg/1) in the arsenic workers and 0.1 ymole/1 in the referents. In 21 arsenic workers with no or very low exposure to vibra ting hand tools, the FSP during cooling had increased significantly after 3 years wit h the lower arsenic exposure. There was no change in FSP during the summer vacation, whereas urinary levels of arsenic decreased to normal values. Thus there seems to be a slow improvement of finger blood circ ulation which is independent of short-term fluctuations in the exposure to arsenic. No seasonal variation was found in FSP during cooling with the standardized method used. When the NCV-measurements were repeated five years later the difference between arsenic workers and referents had increased, despite the fact that 14 of the 47 arsenic workers had had no exposure to arsenic during the last 1-5 years. These observations indicate, that in subjects with long term exposure to arsenic, sub-clinical neuropathy is not reversible. Ten milligrams of Ketanserin, a serotonin receptor antagonist, was given intravenously to five arsenic workers with cold-induced vasospasm. Skin temperature and FSP during cooling increased significantly with Ketanserin as compared wit h saline solution. After oral treatment, 2 x 40 mg /day for four weeks, no significant increase of FSP during cooling or rise in skin temperature was found in six arsenic workers and eleven patients with Raynaud's phenomenon. The decrease of vasospastic tendency after intravenous injection of Ketanserin indicated that similar mechanisms might operate in arsenic-induced and other types of Raynaud's phenomenon. A general co nclusion from the five studies in this dissertation is that long-term occupational exposure to arsenic has had adverse effects on the peripheral circulation and nerve conduction. The tendency to vasospasm, but not the sub-clinical neuropathy, seemed to be reversible with decreasing exposure.

S. 1-54: sammanfattning, s. 55-112: 5 uppsatser

digitalisering@umu

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17

GEMNE, GÖSTA. "PATHOPHYSIOLOGY OF WHITE FINGERS IN WORKERS USING HAND-HELD VIBRATING TOOLS." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/16057.

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18

Piotto, Daniela Gerent Petry [UNIFESP]. "Estudo prospectivo de capilaroscopia periungueal em crianças e adolescentes com dermatomiosite e fenômeno de Raynaud." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9593.

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Made available in DSpace on 2015-07-22T20:50:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-06-30
A capilaroscopia periungueal (CPU) é um método diagnóstico simples, não invasivo e de baixo custo que permite o estudo in vivo do estado funcional e morfológico da rede capilar através da visualização direta da fileira distal de capilares da região periungueal dos dedos das mãos. Ela é usada para distinguir o fenômeno de Raynaud (FRy) primário do secundário, como preditor de prognóstico para as colagenoses e para diferenciar doença ativa de inativa (principalmente na dermatomiosite). Nossos objetivos foram avaliar o valor da CPU na evolução da atividade de doença na dermatomiosite juvenil (DMJ) e avaliar os achados clínicos e de CPU de uma coorte de crianças e adolescentes com FRy sem critérios para doenças reumáticas auto-imunes (DRAI). Foram avaliados prospectivamente 30 pacientes com DMJ (critérios de Bohan e Peter) e 40 crianças e adolescentes com FRy através do exame clínico (alterações cutâneas e força muscular) e laboratorial (enzimas musculares, provas de fase aguda e anticorpo antinuclear - AAN). A avaliação capilaroscópica foi realizada através de um microscópio óptico com aumentos de 10 e 16 vezes. O grupo de pacientes com DMJ compreendeu 20 pacientes do sexo feminino (66,6%), com média de idade de 10,4 anos e tempo médio de evolução da doença de 4 anos. Na primeira avaliação 22 das 26 capilaroscopias periungueais (84,6%) realizadas durante a fase ativa exibiram padrão escleroderma (padrão SD) e os 4 exames realizados durante a remissão foram normais. Portanto, em 26 dos 30 pacientes (86,6%) avaliados os dados clínicos e laboratoriais foram associados com os achados capilaroscópicos. Na avaliação prospectiva 15 dos 18 pacientes (83,3%) que mantinham atividade de doença persistiam com padrão SD na CPU e 10 dos 12 exames (83,3%) realizados durante a remissão foram normais ou apresentaram melhora do padrão SD. Portanto, em 25 dos 30 pacientes (83,3%) reavaliados a CPU também se associou com a presença ou ausência de atividade da doença. No grupo de crianças e adolescentes com FRy, 30 (75%) eram do sexo feminino, com média de idade de 14,6 anos e tempo médio de evolução de 4,2 anos. A média de idade do início dos sintomas foi de 10,4 anos e o tempo médio até o diagnóstico de 1,4 anos. Treze (32,5%) dos 40 pacientes apresentaram AAN positivo. Cinco pacientes (12,5%) apresentaram alterações na CPU inicial: 4 microangiopatia inespecífica e 1 padrão SD. Todos foram avaliados prospectivamente e 3 (7,5%) apresentaram alterações na CPU com tempo médio entre as avaliações de 1,6 anos (dos quais 2 sem alterações na 1ª avaliação). Dois pacientes com padrão SD na CPU apresentaram durante a evolução doença mista do tecido conjuntivo e hipotireoidismo respectivamente. Em um paciente com CPU normal e presença de auto-anticorpos foi diagnosticado lúpus eritematoso sistêmico após 1 ano da avaliação inicial. A CPU se associa com a atividade da DMJ e é útil para excluir doenças reumáticas ou outra doença auto-imune nas crianças e adolescentes com FRy.
Objective: To evaluate prospectively the clinical features and nailfold capillaroscopy findings of a cohort of children and adolescents who presented Raynaud´s phenomenon without criteria for auto-immune rheumatic diseases. Methods: We included 40 children and adolescents with Raynaud’s phenomenon. Each patient was clinically evaluated and laboratory exams were performed, including antinuclear antibodies. Concomitantly we also performed a nailfold capillaroscopy by using a optical microscope with a magnification of 10 and 16X. Results: Thirty (75%) out of 40 patients were girls with a mean age of 14.6 years and mean follow-up time of 4.2 years. The mean age at disease onset was 10.4 years and the mean time until diagnosis 1.4 years. Thirteen out of 40 patients (32,5%) presented antinuclear antibodies positivity. Five (12.5%) patients had altered nailfold capillaroscopy: 4 inespecific microangiopathy and 1 scleroderma pattern. All patients were prospectively evaluated within a mean interval time of 1.6 years and 3 (7.5%) patients presented nailfold capillaroscopy alterations. Two patients that showed scleroderma pattern at the nailfold capillaroscopy presented during the follow-up mixed connective tissue disease and hypothyroidism, respectively. In a patient with normal nailfold capillaroscopy and auto-antibodies positivity systemic lupus erythematosus was diagnosed after 1 year of initial evaluation. Conclusions: Raynaud´s phenomenon remains primary in most cases, however nailfold capillaroscopy is useful to help in exclusion of auto-immune rheumatic diseases or other auto-immune diseases.
TEDE
BV UNIFESP: Teses e dissertações

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Eid, Ali Hussein. "Molecular regulation of vascular alpha 2C adrenoceptors." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu100875938.

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Thesis (Ph. D.)--Ohio State University, 2004.
Title from first page of PDF file. Document formatted into pages; contains xxii, 260 p.; also includes graphics (some col.). Includes bibliographical references (p. 232-260). Available online via OhioLINK's ETD Center

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20

Daftardar, Saloni B. "Ultrasound-mediated Topical Delivery of Econazole nitrate for Treating Raynaud’s Phenomenon." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1501501075880616.

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Bahl, Dherya. "Design and Characterization of Topical Econazole Nitrate Formulations for Treating Raynaud’s Phenomenon." University of Toledo Health Science Campus / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=mco1501518069682334.

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22

LASPRESES, PASCAL. "Phenomene de raynaud : bilan predictif et discriminant ; formes idiopathiques et formes secondaires ; etude retrospective de 98 cas." Reims, 1991. http://www.theses.fr/1991REIMM077.

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23

CHANUT, MYRIAM. "Le phenomene de raynaud en medecine interne : etude clinique et etiologique de 122 consultants." Lyon 1, 1990. http://www.theses.fr/1990LYO1M026.

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Durant, Cécile Pistorius Marc-Antoine. "Analyse des phénomènes de Raynaud sclérodermiques." [S.l.] : [s.n.], 2007. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=24736.

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25

Assier, Valérie. "La maladie de Raynaud : étiologies, thérapeutiques." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2P050.

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26

BETTI, PATRICK. "Maladie de raynaud et magnesium : place de la theorie magnesienne dans la pathogenie du syndrome de raynaud primitif a la lumiere des donnees de la litterature." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20184.

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27

Jourlin, Pascale. "Le phénomène de Raynaud du poumon : mythe ou réalité ? : étude des variations de la DLCO après un test au froid chez 20 patients porteurs d'un phénomème de Raynaud." Saint-Etienne, 1988. http://www.theses.fr/1988STET6050.

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BEURRIER, PHILIPPE. "Discussion nosologique a propos de la maladie de raynaud : revelation tardive." Nantes, 1991. http://www.theses.fr/1991NANT113M.

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Clottes, Corinne. "Le phénomène de Raynaud sévère : aspects étiologiques et thérapeutiques." Montpellier 1, 2000. http://www.theses.fr/2000MON11170.

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Auxenfants, Eric. "Les troubles moteurs oesophagiens au cours de la sclerodermie et du syndrome du raynaud suspect : etude retrospective de 50 dossiers." Lille 2, 1992. http://www.theses.fr/1992LIL2M192.

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Hartmann, Peter [Verfasser]. "Risikofaktoren des Raynaud-Syndroms in einer metaanalytischen Betrachtung / Peter Hartmann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1032558253/34.

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Mohokum, Melvin [Verfasser]. "Ursachen des Raynaud-Syndroms in einer metaanalytischen Betrachtung / Melvin Mohokum." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1032171081/34.

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Jolivert, Caroline. "Syndrome de Raynaud au cours d'un traitement par interféron alpha (à propos d'un cas clinique)." Bordeaux 2, 2000. http://www.theses.fr/2000BOR2M045.

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CLEENEWERCK, NATHALIE. "Lupus erythemateux dissemine et cryoglobulines : a partir de 30 cas de patients lupiques." Reims, 1992. http://www.theses.fr/1992REIMM010.

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ROASIO, GENEVIEVE. "A propos d'un cas d'une association urticaire au froid, phenomene de raynaud et cryoglobulinemie : revue de la litterature." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20256.

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Balaresque, Alix. "La capillaroscopie dans les syndromes de Raynaud idiopathiques suspects : experience rouennaise." Rouen, 1989. http://www.theses.fr/1989ROUEM002.

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Bertão, Manuela Vidigal. "Estudo de prevalência do fenómeno de Raynaud na região do Grande Porto." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/62201.

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Bertão, Manuela Vidigal. "Estudo de prevalência do fenómeno de Raynaud na região do Grande Porto." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/62201.

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Müller-Eschner, Matthias. "Darstellung der Auswirkungen von kohlensäurehaltigen Handbädern bei Patienten mit systemischer Sklerose und Raynaud-Phänomen mittels Doppler und B-Flow Ultraschalltechnik." Giessen VVB Laufersweiler, 2009. http://d-nb.info/996005188/04.

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Boyer, Zigna Ariel. "Contribution à l' étude des acrosyndromes professionnels par vibrations : proposition d' un protocole d' investigation et d' évaluation des troubles." Clermont-Ferrand 1, 1987. http://www.theses.fr/1987CLF11015.

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A partir de 10 dossiers, l' auteur propose un protocole d' investigation des acrosyndromes professionnels par vibration, défini par l' institut de médecine du travail, conduit avec la collaboration du centre Jean Perrin, en vue d' objectiver, d' évaluer et d' indemniser ces troubles qui font l' objet d' une prise en charge au tableau n° 69 des maladies professionnelles indemnisables du régime général de la Sécurité Sociale. Après une étude du phénomène de Raynaud, sa sémiologie, ses étiologies, sa physiopathologie, ses méthodes d' investigation, l' auteur présente 10 dossiers réunissant les activités professionnelles, les allégations cliniques, les résultats des explorations angioscintigraphiques des deux mains, et des explorations thermographiques (en équilibre thermique et après épreuve de stimulation). L' intérêt de ce protocole est discuté.

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Vargel, Michelland Murielle. "Influence de la température sur la vasomotricité artériolaire : du vaisseau isolé au phénomène de Raynaud." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10260.

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Ce travail a pour but de determiner le role du froid dans la survenue du vasospasme rencontre dans le phenomene de raynaud. Le phenomene de raynaud, acrosyndrome decrit en 1862 par m. Raynaud, s'affirme comme le plus frequent des troubles vasomoteurs des extremites. Le froid est toujours decrit comme un des facteurs declenchant du vasospasme. Dans une premiere partie de ce travail, l'influence de la temperature sur la reactivite noradrenergique vasculaire est observee in vitro, sur des arteres isolees de rat et, in vivo, sur des arterioles cutanees dans la chambre cutanee dorsale du hamster. Puis une seconde partie experimentale chez l'homme permet de mesurer avec un laser doppler imageur l'effet du froid sur la microcirculation cutanee digitale dans 3 populations (temoins sains, phenomene de raynaud primaire et phenomene de raynaud secondaire). Puis l'influence des facteurs climatiques sur la frequence et l'intensite du vasopasme dans la population generale sujette au phenomene de raynaud est evaluee par une etude epidemiologique. Sur le modele des vaisseaux isoles, la temperature de 25c induit une reaction opposee pour les vaisseaux profonds et les vaisseaux cutanes. Ce refroidissement n'a pas d'effet mesurable sur le diametre des arterioles dans la chambre cutanee dorsale du hamster. A l'inverse, sur les deux modeles animaux, le froid potentialise la reponse vasculaire lors d'une stimulation noradrenergique. La mesure du flux realisee a partir des cartographies de flux suit un profil de variation identiques dans les trois groupes de personnes etudies. C'est la valeur basale du flux qui differe entre temoins sains et patients. Il ressort une sensibilite particuliere au froid sur l'echantillon de population etudie. Ces resultats suggerent que le froid seul ne suffit pas a expliquer la survenue du vasospasme chez des patients souffrant d'un phenomene de raynaud. Neanmoins, les resultats sur les modeles animaux montrent l'effet amplificateur, peut etre catalyseur, d'un refroidissement sur la reponse vasculaire a une stimulation noradrenergique. Chez des patients atteint d'un phenomene de raynaud, le froid viendrait s'associer a un etat basal perturbe pour amplifier la reponse vasoconstrictrice.

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Diaz, Gilles. "Ischémies digitales et affections néoplasiques, à propos d'un cas." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M131.

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Schilk, Ingo. "Die Wertigkeit unterschiedlicher Untersuchungsverfahren zur Beurteilung der peripheren Zirkulation in der apparativen Diagnostik des Raynaud-Phänomens." [S.l.] : [s.n.], 2001. http://archiv.ub.uni-marburg.de/diss/z2002/0001/.

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Hua, Yue. "Modélisation de l'influence des sollicitations mécaniques dynamiques sur les phénomènes de remodelage et de croissance des vaisseaux sanguins des membres supérieurs." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0134/document.

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Le syndrome de vibration main-bras (HAVS) est généralement provoqué par l'utilisation d'outils électriques portatifs sur le long terme ; il se manifeste après une exposition au froid, en provoquant une forte et anormale vasoconstriction des vaisseaux sanguins. L'objectif de la thèse est d'établir un nouveau modèle prédictif des changements géométriques et structurels des parois des capillaires causés par l'exposition des membres supérieurs aux vibrations. Le contexte médical du HAVS est rappelé en premier lieu, en particulier les mécanismes pathologiques sous-jacents. Les modèles constitutifs des tissus mous de la pulpe de doigt et de la paroi du vaisseau en croissance issus de la littérature sont rappelés. Dans la troisième partie de la thèse, les paramètres élastiques et visqueux de la pulpe du doigt sont identifiés par le recalage des résultats de la simulation d'un modèle 2D d'une section transversale du bout du doigt avec des données expérimentales. La dernière partie de la thèse aborde la modélisation de la croissance des capillaires induite par la vibration de l'outil, en considérant des échelles spatiales et temporelles macroscopique et microscopique. Le problème spatial multi-échelles est résolu par une méthode de zoom structural, le champ de déformation calculé à l’échelle macroscopique définissant la condition limite appliquée ensuite à l’échelle microscopique. Le problème multi-échelle de temps est résolu en transformant le problème dynamique en un problème équivalent quasi-statique. Les résultats obtenus montrent que les vibrations induisent l'épaississement de la paroi du capillaire, l’effet étant maximum au voisinage de la fréquence de résonance. Des analyses paramétriques sont réalisées pour étudier la relation entre la croissance des capillaires en fonction de la localisation dans la pulpe du doigt, la fréquence de la vibration, l’amplitude de la pré-charge statique, et la dose de vibrations
Hand-Arm Vibration syndrome (HAVS) is usually caused by long-term use of hand-held power tools. It typically occurs after exposure to cold, causing an abnormally strong vasoconstriction of blood vessels. A model predicting the geometrical and structural changes of the arterial walls caused by vibration exposure is developed for the first time in this thesis. The medical context of HAVS is first recalled, especially the underlying pathological mechanisms. The constitutive models for the finger pulp and the growth of the vessel wall from the literature are used as a basis for the modeling of the arterial wall remodeling under exposure to vibration. The elastic and viscous parameters of the fingertip have been identified by adjusting the simulation results of a 2D model of fingertip cross-section to available experimental data. The last part of the thesis develops a first attempt to build the growth model of capillary induced by the tool vibration, considering multiscale spatial and temporal aspects. The two-scale spatial problem is solved by a structure focus, the deformation field computed at the macro level defining the boundary condition next applied at the microscopic level. The two-scale time problem is solved by transforming the dynamic problem into a quasi-static problem. The results obtained show that vibration induces an increase of the thickness of the capillary's wall. Parametric analyses were carried out to study the relationships between the capillary growth and their localization within finger’s pulp, the vibration frequency, the magnitude of the static preload and the vibration dose

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Coutable, Jocelyn. "Contribution à l'étude du passage percutané d'un inhibiteur calcique de la famille des phényl-dihydropyridines : développement et optimisation d'une forme topique." Paris 5, 1991. http://www.theses.fr/1991PA05P618.

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COSTA, Sérgio Henrique Nascente. "USO DE DROGAS PSICOTRÓPICAS POR POLICIAIS MILITARES DE GOIÂNIA E APARECIDA DE GOIÂNIA, GOIÁS, BRASIL." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1549.

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Made available in DSpace on 2014-07-29T15:25:22Z (GMT). No. of bitstreams: 1 tese sergio nascente costa ciencias saude.pdf: 3835674 bytes, checksum: 6034e0701fc67a4a611b07fa22a5df92 (MD5) Previous issue date: 2009-07-01
Licit drugs like alcohol, and illicit drugs such as marijuana, cocaine, opioids and amphetamines, are used by millions of people worldwide. The damage to health occurring due to the acute or chronic, and also due to psychomotor and behavioral changes that these substances cause the users. A situation that deserves special attention is the use of drugs in the workplace, especially in enterprises and institutions in need of constant concentration and emotional balance in labor activities. Thus the objective of this study was to determine the survey of psychotropic drug use among Military Police members in the state of Goiás, Brazil, and correlate it with the frequency in society in general. This study was done by the application of a questionnaire and toxicological analysis of urine samples collected at the beginning of the work day, for the detection of cannabinoids, cocaine, amphetamines, methamphetamine, opiates and benzodiazepines. Study carried out from March to October 2008 in 12 Military Police units in the municipalities of Goiânia and Aparecida de Goiânia. Voluntary participants (n = 221) were interviewed about drug use employing a questionnaire especially designed by the Centro Brasileiro de Informações sobre Drogas Psicotrópicas (CEBRID). Data were analyzed by descriptive statistics to determine the frequency of licit and illicit drug use. The frequency of use was: lifetime tobacco 39.9%; alcohol 87.8%; cannabis 8.1%; cocaine 1.8%; stimulants 7.2%; solvents 10.0%; sedatives, anxiolytics, antidepressants 6.8%; LSD 0.5%; Bentyl® 0.5%; anabolic steroids 5.4%; last year use tobacco 15.4%; alcohol 72.9%; stimulants 6.3%; solvents 0.5%; sedatives, anxiolytics, antidepressants 3.7%; use in the past 30 days tobacco 14.5%; alcohol 57.5%; stimulants 5.0%; solvents 0.5; sedatives, Abstract xvii anxiolytics, antidepressants 3.7%. The prevalence of psychotropic drug use found for Military Police members in the state of Goiás, Brazil, is similar to the results of national and international surveys with civilians, showing that the former are at similar risk to become users of legal and illegal drugs. Moreover, 299 samples of urine was submitted to toxicological analysis by immunochromatographic screening tests; whose positive results for cannabinoids and amphetamines, were referred for confirmation by GC / MS. Thus, the results were as follows: 0.33% of samples positive for amphetamine, 0.67% of samples positive for cannabinoids, 1.34% for benzodiazepines and 97.66% negative. Thus the total percentage of positive samples were 2.34%. The research carried out by military police with voluntary form showed that military and civil community in general, are subject to similar risks of abuse of licit and illicit drugs and it is an alert to development of testing drugs in the workplace, to avoid the consequences arising from the consumption of psychoactive substances
Drogas lícitas, como o álcool, e ilícitas, como a maconha, a cocaína, os opióides e as anfetaminas são utilizadas por milhões de pessoas no mundo. Os prejuízos à saúde ocorrem em virtude da intoxicação aguda ou crônica, e também devido às alterações comportamentais e psicomotoras que essas substâncias provocam nos usuários. Uma das situações que merecem especial atenção é o uso de drogas no ambiente de trabalho, notadamente em empresas e/ou instituições que necessitam de constante concentração e equilíbrio emocional nas atividades laborais. Desta forma, o objetivo deste trabalho foi realizar um levantamento sobre o uso de drogas psicotrópicas em 12 unidades da Polícia Militar do Estado de Goiás, nos municípios de Goiânia e Aparecida de Goiânia. Este levantamento foi feito por meio da aplicação de um questionário e da realização de análise toxicológica, em amostras de urina coletadas no início da jornada de trabalho, para a pesquisa de canabinóides, cocaína, anfetaminas, metanfetaminas, opiáceos e benzodiazepínicos. Os resultados obtidos a partir da aplicação do questionário em 221 sujeitos foram os seguintes: uso na vida tabaco 39,9%; álcool 87,8%; maconha 8,1%; cocaína 1,8%; estimulantes 7,2%; solventes 10,0%; sedativos, ansiolíticos, antidepressivos 6,8%; LSD 0,5%; Bentyl® 0,5%; anabolic steroids 5,4%; uso no último ano tabaco 15,4%; álcool 72,9%; estimulantes 6,3%; solventes 0.5%; sedativos, ansiolíticos, antidepressivos 3,7%; uso no mês anterior tabaco 14,5%; álcool 57,5%; estimulantes 5,0%; solventes 0,5 %; sedativos, ansiolíticos, antidepressivos 3,7%. Por outro lado, as 299 amostras de urina obtidas para análise toxicológica foram submetidas aos testes de triagem imunocromatográficos, cujos resultados Resumo xv positivos para canabinóides e anfetaminas foram encaminhados para confirmação por GC/MS. Desta forma, os resultados foram os seguintes: 0,33% de amostras positivas para anfetaminas; 0,67% de amostras positivas para canabinóides; 1,34% para benzodiazepínicos; 97,66% foram de resultados negativos. Assim o percentual total de amostras positivas foi de 2,34%. Não foi encontrado nenhum caso de associação de drogas. Em relação aos casos positivos, 57,1% corresponderam ao uso de benzodiazepínicos; 28,6% ao uso de canabinóides e 14,3% ao uso de anfetaminas. A pesquisa realizada de forma inédita, voluntariamente, em policiais militares revela que estes profissionais, como a comunidade civil em geral, estão sujeitos a riscos semelhantes de se tornarem usuários de drogas lícitas e ilícitas, e alerta em relação à necessidade da implantação de testes de drogas no ambiente de trabalho, visando evitar as conseqüências decorrentes do consumo de substâncias psicoativas

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47

Fontana, Luc. "Troubles angioneurotiques distaux secondaires a une exposition professionnelle au chlorure de vinyle monomere : 1. contribution a la connaissance physiopathologique. 2. evaluation de nouvelles methodes biomedicales d'investigations." Clermont-Ferrand 1, 1996. http://www.theses.fr/1996CLF1MM03.

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Ornstein, Henrik, and William Uddling. "Vibrationer från handhållna verktyg : En mätstudie av hantverkares vibrationsexponering på byggarbetsplatsen." Thesis, Karlstads universitet, Fakulteten för hälsa, natur- och teknikvetenskap (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-67836.

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Den vanligaste arbetssjukdomen är idag vibrationsskador där en av de mest utsatta arbetsgrupperna är hantverkare i byggbranschen. Syftet med studien är att ta fram en åtgärdsplan för att minska skaderisken från hand- armvibrationer (HAV) på arbetsplatsen. Undersökningarna har gjorts på Rudsberget, Karlstad där åtta lägenhetshus har varit under konstruktion för byggföretaget NCC. Fem olika arbetsmoment har kontrollerats för att bedöma vibrationsexponeringen som en hantverkare utsätts för under en genomsnittlig arbetsdag. Detta har gjorts med två mätmetoder, manuella beräkningar med tidtagarur samt HealthVib-handskar som använder sig av en sensor i handflatan.Resultatet visade att 6 av 13 mätningar översteg insatsvärdet och 1 av 13 översteg gränsvärdet. Iakttagelser visar att när arbetet har utförts mot moment som innehåller betong har vibrationsmängden ökat i jämförelse med arbete mot trä eller andra mjukare material. Förlängd vibrationsexponering på flera arbetsmoment visar att det finns risk för kärlskada och neurosensorisk skada beroende på intensiteten och längden av arbetet. Studien har avgränsat sig mot NCC:s egna hantverkare, alltså har inga mätningar gjorts på olika underentreprenörer eller betongarbetare på arbetsplatsen.Studiens slutsats framhäver åtgärder i både organisatorisk och teknisk form, som kan genomföras i både tidigt och sent stadie i projektet. Några av de viktigaste åtgärderna är att förmedla till hantverkarna att rotera arbetsuppgifterna mellan varandra, göra en förbättrad riskbedömning, informera hantverkarna om skadeverkningarna och vibrationsnivåer. Utöver det kan vibrationsexponeringen reduceras i planeringsfasen. Till exempel vid köksmontering byggs kök mot en träregelvägg istället för en bärande betongvägg.
The most common occupational disease today is hand-arm vibration syndrome where construction workers are the most exposed group. The purpose of this study was to develop an action plan designed to lower the exposure to hand-arm vibration syndrome (HAVS). The examinations have been carried out at Rudsberget, Karlstad where eight, six to eight stories apartment buildings have been under construction by Nordic Construction Company (NCC). Five different work elements were studied at the construction site to determine the exposure of hand-arm vibration that a construction worker is exposed to during a regular workday. The methods used were manual tests with stopwatches as well as HealthVib-gloves with a sensor that collects data while used during the day.The results showed that 6 out of 13 exceeded the exposure action value (EAV) and 1 out of 13 exceeded the exposure limit value (ELV). Observations showed that work carried out against concrete structures increased vibration levels compared to other softer materials, wood as an example. Prolonged vibration exposure on several work elements show an increased risk of developing both neurological and vascular injuries. Dependent on the length and intensity of the exposure the severity of the damage does vary. This study is limited to examining construction workers contracted by NCC, excluding workers casting concrete as well as sub-contractors.The conclusion highlights solutions that consists of organizational and technical forms. These solutions are then applied at an early or late stage of the project. Some of the key solutions are to convey the importance of rotating work tasks between the construction workers, do a better risk assessment, inform the workers of the harmful effects of vibrations and teach them of the different exposure values. Beyond that can vibration exposure be reduced in the architectural phase. For an example could the kitchen be constructed against a wooden wall frame instead of a load bearing concrete wall.

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Jantschak, Florian [Verfasser]. "Der α2C-Adrenozeptor als Zielstruktur für Arzneistoffe zur Behandlung des Raynaud-Phänomens, von Lungenödemen und der Schizophrenie / Florian Jantschak." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1037343190/34.

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Ferreira, Antonio Jorge. "Modèles intègres dérivés et ses applications à l'étude de certains espaces des modules rigides analytiques dérivés." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30040.

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Dans cette thèse, on étude différents aspects de la théorie de la géométrie dérivée rigide analytique. D'abord, on étude et généralise le théorèome classique de localisation de Raynaud au cadre dérivé. Muni d'une théorie des modèles formels, développé dans cette thèse, on étude ses applications à l'étude des certains espaces de modules dérivés. Certains exemples correspondent bien au champ d'Hilbert rigide analytique dérivé et le champ des représentations continues des groupes fondamentales des variétés lisses sur un corps fini. La structure dérivée sur ce dernier nos permet de comprendre totalement la théorie de déformations des représentations galoisiennes. Enfin, on montre que ce dernier admet une structure sympléctique dérivé naturel. Ce dernier résultat s'appuye dans le théorème de HKR en géométrie analytique qui on prouve en collaboration avec F. Petit et M. Porta
In this thesis, we study different aspects of derived k-analytic geometry. Namely, we extend the theory of classical formal models for rigid k-analytic spaces to the derived setting. Having a theory of derived formal models at our disposal we proceed to study certain applications such as the representability of derived Hilbert stack in the derived k-analytic setting. We construct a moduli stack of derived k-adic representations of profinite spaces and prove its geometricity as a derived k-analytic stack. Under certain hypothesis we show the existence of a natural shifted symplectic structure on it. Our main applications is to study pro-étale k-adic local systems on smooth schemes in positive characteristic. Finally, we study at length an analytic analogue (both over the field of complex numbers C and over a non-archimedean field k) of the structured algebraic HKR, proved by Toen and Vezzosi

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Dissertations / Theses on the topic 'Raynaud's'

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