Academic literature on the topic 'Rats spontanément hypertendus'
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Journal articles on the topic "Rats spontanément hypertendus"
Savelli, Jean-Luc, Michel Narce, Véronique Fustier, and Jean-Pierre Poisson. "Composition en acides gras des hémisphères cérébraux de rats spontanément hypertendus allaités par des femelles Wistar." Comptes Rendus Biologies 326, no. 6 (June 2003): 543–52. http://dx.doi.org/10.1016/s1631-0691(03)00145-8.
Full textMaskali, F., S. Poussier, H. Louis, N. Didot, C. Person, V. Regnault, N. Sloboda, G. Karcher, P. Y. Marie, and P. Lacolley. "M001 Caractérisation in vivo et par microtep des remodelages cardiovasculaire et cérébral précoces dans les modèles expérimentaux de rats spontanément hypertendus." Archives of Cardiovascular Diseases 102 (March 2009): S121—S122. http://dx.doi.org/10.1016/s1875-2136(09)72426-x.
Full textDissertations / Theses on the topic "Rats spontanément hypertendus"
Savelli, Jean-Luc. "Influence du diabète non insulino dépendant expérimental et du vieillissement sur la biosynthèse des acides gras à longues chaînes chez le rat spontanément hypertendu." Corte, 2003. http://www.theses.fr/2003CORT3074.
Full textStreptozotocin non-insulin-dependent diabetes mellitus and aging effects on long chain fatty acids metabolism, and paerticulary on the biosynthesis of N-6 series essential fatty acids, wistar Kyoto normotensive rats (WKY) , 10 30 and 90 days old, submitted or not, at 2 days of age, to intraperitoneally injections of streptozotocin. Decreased 9 carbons (N-9) 6 and 5 (N-6 series) desaturations were observed in liver microsomes of diabetic SHR. The fatty acid composition of microsomes, heart, kidney and brain total lipids, phospholipids and triglycerides is partially in agreement with the altered desaturase activities. Besides, our results indicate that evolution of desaturation activities with age depended on the substrate being studied, but that for each substrate desaturation activity desaturation evolution was different. This study on the basis of the same diet, allow data on unsaturated fatty acid metabolism pathways involved in non insulin dependent diabetes mellitus, alone or associated to hypertension, our aim is to determine, in a subsequent work, if it is possible or not to modulate this metabolism, during associated diabetes-hypertension, using appropriated lipid diet and/or therapy, and to established nutritional and/or therapy recommendations focused on unsaturated fatty acids
Foucher, Christelle. "Contribution de la résonance paramagnétique électronique a l'étude de la fluidité des lipoprotéines humaines et à l'étude de la fluidité des membranes microsomales hépatiques de rats spontanément hypertendus : Influence des acides gras." Dijon, 1997. http://www.theses.fr/1997DIJOS014.
Full textRuchoux-Goupil, de Bouillé Marie-Magdeleine. "Aspects vasculaires et neuropathologiques du rat spontanément hypertendu (SHR)." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX21902.
Full textSzmicseková, Kristína. "Non-neuronal cholinergic system." Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5223.
Full textIntroduction: Despite the lack of cholinergic innervation, vessels are highly reactive to the presence of acetylcholine (ACh). Moreover, this neurotransmitter is commonly used to assess the endothelial function of vessels. However, information about vascular cholinesterases (ChE), the enzymes that terminate ACh action, is spares. The main aim of this dissertation thesis was to characterize vascular ChE and overall non-neuronal cholinergic system in the aorta under physiological and pathological conditions. Methods: Adult male Wistar rats and spontaneously hypertensive rats (SHR) were used in the project, fed either with regular or high-fat diet. Relative expression of studied enzymes and transporters were determined by RT-qPCR method. ChE activities in tissue extracts were measured by Ellman's assay, activity staining was performed by Tsuji’s method and proteins localizations were done by dual immunohistochemistry. Molecular forms of ChE were studied by sucrose gradients. Results and conclusion: The enzymes and transporters necessary for ACh synthesis, storage, release, and degradation were detected in the rat aorta at mRNA and at protein levels. This confirms that aorta is a non-neuronal cholinergic tissue, capable to fully support the ACh life cycle. ChE are present mainly as PRiMA-anchored forms in each part of the aorta, while butyrylcholinesterase (BChE) is the dominant ChE, localized primarily in the smooth muscle. In SHR, lower levels of BChE were detected, accompanied by decreased relative expressions of carnitine acetyltransferase and organic cation transporters. This suggests lower cholinergic signaling in SHR aorta as compared to normotensive rats. In the pharmacological experiment, both inhibition of BChE and high-fat diet resulted in significant weight gain and increased serum TAG levels. Moreover, a high-fat diet induced mRNA expression of BChE. Our data suggest BChE involvement in lipid metabolism
Úvod: Napriek absencii cholínergickej inervácie, cievy sú vysoko reaktívne na prítomnosť acetylcholínu (ACh). Okrem toho, práve tento neurotransmiter sa využíva vo fyziologických experimentoch na sledovanie funkčnosti endotelu. Napriek tomu však chýbajú informácie o prítomnosti cholínesteráz (ChE), enzýmov, ktoré ukončujú jeho účinok v cievach. Cieľom tejto dizertačnej práce bola detailne charakterizovať tieto enzýmy a kompletne preštudovať prítomnosť komponentov neneuronálneho cholínergického systému v aorte normotenzných a spontánne hypertenzných potkanov (SHR). Metódy: V experimentoch boli použité 12-týždňové potkany rodu Wistar a SHR, ktoré boli kŕmené buď štandardnou alebo vysoko-tukovou stravou. Relatívna expresia študovaných enzýmov a transportérov bola stanovená metódou RT-qPCR. Aktivity ChE boli stanovené v tkanivových extraktoch pomocou Ellmanovej metódy, aktivitné farbenie bolo prevedené podľa Tsujiho metódy. Na vizualizáciu a lokalizáciu bola využitá metóda dvojfarebnej immunohistochémie. Molekulové formy ChE boli charakterizované pomocou metódy sacharózového gradientu. Výsledky a diskusia: Všetky enzýmy a transportéry, ktoré sú potrebné na syntézu, uchovávanie, vylučovanie a degradáciu ACh boli potvrdené nielen na úrovni mRNA, ale aj na úrovni proteínov. Tieto zistenia potvrdzujú, že aorta patrí medzi neneuronálne cholínergické tkanivá. ChE sú prítomné primárne v PRiMA-kotvenej forme v každej časti aorty, pričom butyrylcholínesteráza (BChE) je dominantná a je prítomná hlavne v hladkom svalstve. V spontánne hypertenznom modeli bola detegovaná nižšia BChE aktivita a tiež nižšia relatívna expresia karnitínacetyltransferázy a organických katiónových transportérov. Vo farmakologickom experimente, aj inhibícia BChE, aj vysoko-tuková strava spôsobila signifikantný prírastok hmotnosti a zvýšenie sérových hladín triacylglycerolov. Okrem toho, vysoko-tuková strava indukovala zvýšenie hladín mRNA pre BChE, čo naznačuje dôležitú úlohu tohto enzýmu nielen vo fyziológii ciev, ale aj v metabolizme lipidov
Remmal, Adnane. "Métabolisme des phospholipides dans les plaquettes du rat spontanément hypertendu." Paris 11, 1987. http://www.theses.fr/1987PA112275.
Full textMoore, Nicholas D. "Effet de différents traitements parentaux sur le développement de l'hypertension arterielle chez le rat spontanément hypertendu." Rouen, 1985. http://www.theses.fr/1985ROUE06NR.
Full textAit, Aissa Karima. "Étude de l'implication des cellules musculaires lisses vasculaires dans la distensibilité et le phénotype thrombotique dans des modèles murins." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0202/document.
Full textThe hypothesis that hypertension may confer a hypercoagulable state arises from the main complications associated with hypertension, stroke and myocardial infarction. Our objective was to determine whether spontaneous hypertension confers changes in the coagulation proteins and the thrombin generating capacity in blood and the vascular wall. We used the model of spontaneously hypertensive rats (SHR) compared with Wistar rats. Thrombin generation was lower in platelet-rich plasma and platelet-free plasma from SHR compared to Wistar. This was related to lower tissue factor (TF) and prothrombin as well as higher TFPI levels in SHR plasma. In contrast, the addition of thoracic aorta rings of SHR to a Wistar plasma pool resulted in a higher increase in thrombin generation compared to the addition of equivalent rings from Wistar. Whereas no difference was observed for endothelial cells, thrombin formation was higher at the surface of cultured SHR aortic SMCs than from Wistar. Exposure of negatively-charged phospholipids was higher on SHR than on Wistar rings as well as on SMCs. TF and TFPI activities were higher in SHR SMCs. These results show opposite thrombin generating capacity of plasma and vessel walls in SHR compared to Wistar. The higher prothrombotic phenotype of the SHR vessel wall was due to the ability of SMCs to support thrombin generation. These findings suggest that the hypertension-induced membrane phospholipid reorganization and synthesis of procoagulant molecules in SMCs provide substrates for increased thrombin formation within the vessel wall
Frenoux, Jean-Marie. "Métabolisme lipidique et résistance au stress oxydatif chez le rat spontanément hypertendu : effets de la vitamine E et des acides gras polyinsaturés alimentaires." Dijon, 2000. http://www.theses.fr/2000DIJOS088.
Full textSauvaget, Frédérique. "Influence de l’inhibition des récepteurs AT1 de l’angiotensine II sur la relaxation vasculaire β-adrénergique : : étude des β-bloquants vasodilatateurs chez le rat spontanément hypertendu." Nantes, 2011. https://archive.bu.univ-nantes.fr/pollux/show/show?id=ffc5daeb-10d2-4a8d-b875-9ac829f958a2.
Full textThe β-adrenergic (β-A)-induced vasorelaxation is mediated by three receptor subtypes (β1-, β2- and β3-AR), whose effects are more or less impaired in hypertension. This work consisted in assessing the role of β-ARs in carteolol and celiprolol-induced relaxant effects in Wistar Kyoto (WKY) and spontaneously hypertensive rat (SHR) aorta and hinquarter vessels. Angiotensin II, the major component of renin-angiotensin system (RAS), by stimulating AT1 receptors, induces a vasoconstrictor effect that contributes to unbalance between vasonconstrictor and vasodilator events in hypertension. Thus, this work also consisted in determining if the two β-blockers-induced vasodilator effects were modified by a RAS AT1 receptor antagonist. This study shows that, in SHR, the endothelial β1/β2-A NO dependant-induced relaxant effect of celiprolol is impaired in aorta, whereas it is not in hinquarter vessels. It lights for the first time the β3-AR involvement in vasodilator-induced effects of celiprolol in WKY rat hinquarter vessels. It shows carteolol-induced α1-adrenergic antagonist and antioxydant properties in SHR aorta. This study also shows that RAS AT1 receptor inhibition improves carteolol and celiprolol-induced relaxant effects in SHR aorta, maybe by reducing α1-adrenergic effects and by promoting β-A effects respectively. However, RAS does not seem to play any pathophysiologic role in relaxation of hinquarter vessels
Merlin, Jean-François. "Régulation de la biosynthèse des acides gras polyinsaturés chez le rat spontanément hypertendu SHR : influence d'une inhibition pharmacologique de la Delta-6 désaturase et effets d'un régime enrichi en isomères conjugués de l'acide linoléique (CLA)." Dijon, 2006. http://www.theses.fr/2006DIJOS011.
Full textArterial hypertension (AHT) frequently coexists with numerous metabolic abnormalities, particularly abnormalities of polyunsaturated fatty acids (PUFA) composition. Delta-6 desaturase (D6D) is the key step enzyme of hepatic PUFA biosynthesis. D6D is partially inhibited during AHT in spontaneously hypertensive rat (SHR). The consequences of such an inhibition of PUFA biosynthesis on AHT and on hepatic lipid metabolism remain to be investigated. We firstly generated a pharmacological chronic D6D inhibition. This treatment, in addition to block PUFA biosynthesis, exacerbates lipid abnormalities usually shown in SHR, without changing blood pressure. Then, we performed a CLA supplementation (cis-9 trans-11, or trans-10 cis-12 linoleic acids) in SHR. Each isomer activates D6D and corrects some of the lipid abnormalities reported in SHR, while slowing AHT evolution. Moreover, PPARγ and SREBP1c transcription factors could be involved in such SHR hepatic metabolic dysfunctions