Dissertations / Theses on the topic 'Rats Physiology'
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Hohl, Rodrigo. "Padronização de um modelo de indução de overreaching em ratos : desenvolvimento e perspectivas de investigação em natação e esteira." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314733.
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O empirismo do treinamento pode levar a um desequilíbrio entre estímulo da atividade motora e tempo de recuperação do esforço. Como conseqüência o atleta pode experimentar um estado agudo de fadiga e queda de desempenho denominado de overreaching, revertido em poucos dias. A persistência desta situação de desequilíbrio pode levar a um quadro crônico de sensação de fadiga acompanhado de queda de desempenho denominado de síndrome do overtraining (OTS), que pode durar semanas ou meses. O objetivo deste trabalho foi padronizar um protocolo controlado e reprodutível de treinamento em ratos que contivesse um período de desequilíbrio entre o estímulo do exercício e o tempo de recuperação que gerasse queda de desempenho. Há duas formas de exercício em ratos amplamente utilizadas na literatura: a natação e a corrida em esteira. Os primeiros dois capítulos deste trabalho descrevem a padronização de um teste de desempenho em natação, reprodutível ao longo do crescimento animal, para ser utilizado em estudos longitudinais. Para isso, precisávamos considerar o empuxo sofrido pelo animal no meio líquido e validamos (Capítulo I) um aparato de medição de volume para animais vivos e conscientes (AMV). No capítulo II apresentamos os dados da comparação da reprodutibilidade de dois testes de desempenho até a exaustão na natação durante os cinco primeiros meses de vida dos ratos. Um teste com adição de cargas ajustadas de acordo com o porcentual da massa corporal (MC) e outro com cargas constantes (CC). Utilizando o AMV constatamos que a densidade dos animais não variava e, como conseqüência, o teste MC diminuía o tempo de exaustão conforme os ratos aumentavam a massa durante o crescimento, enquanto o teste CC mantinha o tempo de exaustão ao longo do tempo. Paralelamente, iniciamos os estudos com exercício em esteira. No Capítulo III apresentamos um protocolo de 11 semanas, onde o desequilíbrio entre exercício e recuperação foi determinado pelo aumento das sessões diárias nas três últimas semanas em 2, 3 e 4 vezes, com diminuição no tempo de recuperação entre elas. Selecionamos no final desse treinamento dois grupos de ratos, aqueles que apresentaram baixo desempenho (BD) e aqueles que apresentaram aumento ou manutenção do desempenho (AD). Embora ambos os grupos tenham apresentado uma diminuição da massa corporal durante o aumento da freqüência de treinamento, o grupo BD precisou de uma semana a mais de repouso para voltar a aumentar a massa, sem modificar o desempenho. No Capítulo IV comparamos quatro grupos de ratos obtidos desse protocolo (Controle (CO), Treinados (T), BD e AD) em análises no sangue (glutamina, glutamato, alanina e hemograma) e músculo (citrato sintase (CS), lactato desidrogenase e glicogênio). Comparando BD com T e AD observamos: (1) diminuição da concentração plasmática de glutamina e aumento na de glutamato, com valores semelhantes aos do grupo CO; (2) diminuição da capacidade oxidativa (CS) e manutenção dos estoques de glicogênio; (3) leucocitose. Em vista das diferenças encontrada entre os grupos BD e AD, concluímos que o protocolo de treinamento de indução de overreaching representa uma ferramenta metodológica importante, que pode auxiliar no desvendamento dos mecanismos causadores da queda de desempenho nos estados de overreaching/OTS
Abstract: The empirical training can lead to an imbalance between the motor activity stress and recovery. As consequence, the athlete can try an acute state of fatigue and performance decrement called overreaching, reverted in a few days. This continuous unbalance can lead to a chronic fatigue state called as overtraining syndrome (OTS), that may last weeks or months. Our goal was to standardize a controlled and reproducible training protocol in rats that contained an unbalance period between exercise stress and recovery with performance decrement. Two forms of exercise is widely used for rats training in literature: swimming and treadmill running. Chapters I and II describe an adequate standardization for workload in swimming tests when applied to longitudinal studies with sedentary rats. Therefore, considering the rats' buoyance, we validate (Chapter I) an apparatus for measuring conscientious living rat body volume (AMV). In chapter II, we evaluated two types of swimming tests with overload in sedentary rats: one with the load adjusted according to percentage of body weight (BW) and another one with constant load (CL) over time. Through the AMV, we found that the rats' density did not vary significantly, as consequence, MC test showed performance decrement as the rats had their mass increased, while CC test maintained performance along rats growth. In time, we initiate the studies with treadmill exercise. In Chapter III, we present an eleven weeks training protocol where the unbalance between exercise stress and recovery was determined by the increase of the daily sessions in 2, 3 and 4 times in the last three weeks, reducing the recovery time between sessions. We selected two groups of rats in the end of the training protocol, those that presented low performance (BD) and those that presented performance increase or maintenance (AD). Although both groups (AD and BD) showed corporal mass reduction during the increase of the daily frequency, BD group return to increase the mass one week later than AD group, without modifying the performance. In Chapter IV, we compare four groups of rats after the eleven weeks training protocol (Control (CO), Trained (T), AD and BD) in blood (glutamine, glutamate, alanine and hematological variables) and muscle analyses (citrate synthase (CS), lactate dehydrogenase and glycogen). Comparing BD with AD and T groups, we observe: (1) reduction of the glutamine plasma concentration and increase of glutamate, with similar CO values; (2) reduction of the oxidative capacity (CS) and maintenance of the glycogen stores; (3) leucocitosys. We conclude that the training protocol induces the rats to overreaching and it represents a relevant methodological tool in overreaching / OTS metabolical mechanisms research envolved in performance decrement
Doutorado
Fisiologia
Doutor em Biologia Funcional e Molecular
Feng, Tian Bin. "The effects of clomiphene citrate on ovarian function in rats." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28984.
Medicine, Faculty of
Obstetrics and Gynaecology, Department of
Graduate
Chura, Lindsay R. "The effect of chronic and acute maternal stress on expression of placental barrier genes in the rat /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/mhc/2006/143.pdf.
Van, Wageningen Gerhard Derek. "The crossed mesostriatal pathway and circling behaviour in rats." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/21152.
Rats with unilateral 6-OHDA lesions of the nigrostriatal (NS) projection display motor asymmetry in the form of rotational behaviour. The rotation is in the direction ipsilateral with respect to the lesioned side (Ungerstedt 1979). The nett ipsilateral rotations decrease with time, from 1 week to about a month. This decrease has been interpreted as recovery from the lesion-induced motor asymmetry (Glick and Cox 1978). Pritzel et al. (1983) have ascribed the recovery from motor asymmetry to increased activity of a crossed NS projection, which is spared by the ipsilateral lesion. The present study has defined the size and anatomical path of this crossed projection, and has examined its involvement in the behavioural recovery of rats from lesion-induced motor asymmetry. The anatomy of the crossed projection was investigated in male Long-Evans rats using retrograde HRP tract tracing from deposition sites in the striatum.
Lee, Ronald Duane. "The synthesis of 2-((E)-1'-propenyl)-(E)-2-pentenoic acid and its metabolism and pharmacokinetics in rats." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26437.
Pharmaceutical Sciences, Faculty of
Graduate
Anand, Uma. "Target derived influences on primary afferent neurons in rats." Thesis, King's College London (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283305.
Walker, Celia Gillian Rowena. "Dietary and metabolic regulation of leptin in rats." Thesis, The University of Sydney, 2005. https://hdl.handle.net/2123/28031.
Courtois, Frédérique J. "Residual erectile capacity of paraplegic rats." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74335.
Andalib, Ali. "Relationship between a trial fibrillation and hypertension in rats." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83962.
Amoni, Matthew. "The effects of magnesium treatment on short-term changes in heart rate variability, ventricular function and lipid profile in streptozotocin-induced diabetic rats." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24459.
Scott, Trevor Robert. "The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27171.
Wickens, Nicolas John. "Histopathological changes in male wistar rats maintained on a water-based sutherlandia frutescens extract." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/4742.
Aboalgasm, Hamida. "The effects of magnesium administration on cardiac ventricular function, heart rate variability, and myocardial morphological changes in a chronic diabetes disease model in rats." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29579.
Ho, Sze-ngar Sara, and 何思雅. "Synaptic modulation by 5-hydroxytryptamine in the rat hypothalamic paraventricular nucleus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B3194341X.
Gwayi, Noluzuko. "The effects of melatonin on the testis, epididymis and sperm physiology of the Wistar rat." Thesis, Rhodes University, 2001. http://hdl.handle.net/10962/d1005366.
He, Ying 1972 Apr 20. "Impacts of metabolic stress-induced malnutrition and oxidative stress on biochemical changes in the slow- and fast-twitch skeletal muscles of rats." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33774.
Amevor, Solomon Francis. "Renal physiology and aluminum biokinetics : studies in laboratory rats and human subjects /." [S.l.] : [s.n.], 1995. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10972.
Creamer, Katherine. "Characterization of the modulatory effects of neurosteroids on dorsal raphe neurons in a non anaesthetized rats preparation." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101842.
Fayyad, Tariq Hasan. "Is Mitochondrial Development Impaired in Hyperoxic Rats and does this Underpin the Blunting of the Acute Hypoxic Ventilatory Response?" Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1496145386683819.
張永魁 and Yongkui Zhang. "Functional development of otolith afferents in postnatal rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31242716.
Wieczerzak, Krystyna Blanka. "Sensorimotor Analysis of Oxaliplatin Treated Rats." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1432856752.
Ryan, Collen. "Glucose and glycogen metabolism during prolonged swimming and recovery in rats." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7812.
Wang, Qian. "Substrates for muscle glyconeogenesis during prolonged swimming and recovery in rats." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/10224.
Tomie, Jo-Anne B., and University of Lethbridge Faculty of Arts and Science. "Cognitive behavior of rats with thalamic lesions." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1994, 1994. http://hdl.handle.net/10133/60.
xi, 187 leaves : ill., plates ; 29 cm.
何禮昌 and Lai-cheong Ho. "Effects of green tea on ovariectomized rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970540.
Sylvester, Christopher John. "A Demonstration of Photoresponsiveness in Laboratory Rats using Whole Animal and Neuroendocrine Approaches." W&M ScholarWorks, 1997. https://scholarworks.wm.edu/etd/1539626097.
Belkaid, Wiam 1983. "Micropatterning of hippocampal neurons : characterization and implications for studying synaptogenesis." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111597.
陳遠儀 and Yuen-yee Roxanne Chan. "Studies on receptor-mediated uptake of transferrin and iron acquisition by rabbit reticulocytes and a rat hepatoma cell line." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31207571.
Symons, Lawrence André. "A behavioural examination of the intramodal and intemodal consequences of long-term tactile restriction by vibrissae removal in rats." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28134.
Arts, Faculty of
Psychology, Department of
Graduate
Morgan, Michael J. "Stimulation-produced analgesia in the formalin and tail-flick tests : a comparison of brainstem and fore-brain sites in the rat." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65408.
Panenic, Robert. "TTX-induced disuse of mammalian skeletal muscle." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59523.
黎振航 and Chun-hong Lai. "Functional properties of otolith neurons in the vestibular nucleus of young and adult rats during off-vertical axis rotation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31212372.
李克楷 and Huk-kai Paul Lee. "Corticosteroid effects on serotonergic function: a study on the acute and chronic effects of corticosteroids onserotonin uptake and binding in rat synaptosomes and bloodplatelets." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1985. http://hub.hku.hk/bib/B31230519.
黃景祥 and King-chong Stephen Joseph Huang. "Biophysical and biochemical studies of anion secretion in the rat epididymis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31232231.
黎錦明 and Kam-ming Lai. "Structure and function of 5'-nucleotidase of the rat brain." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31232280.
Zhao, Hang, and 趙航. "Melatonin receptors in the rat uterus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241384.
Li, Li, and 李莉. "Melatonin receptors in the rat epididymis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31238907.
Li, Chuan, and 李川. "Spatial coding of gravitational input to the vestibuloolivary pathway and its refinement in development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31539609.
Ma, Chun-wai, and 馬俊偉. "Change in perineuronal net of rat vestibular nuclear neurons in development and in injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010328.
Cameron, Angus Crawford. "The control of physiological programmed cell death : apoptosis." Thesis, The University of Sydney, 1991. http://hdl.handle.net/2123/4751.
Dorrell, Helen Mary. "An investigation of the neurohumoural involvement in the antinociceptive effects of microelectrostimulation in rats." Thesis, University of East London, 1992. http://roar.uel.ac.uk/1247/.
Wong, Wing-man Miranda, and 黃詠雯. "Effects of Hawthorn extract on blood pressure in anesthetized rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31972305.
Stump, Craig Stephan. "Hindlimb muscle glucose uptake and metabolism in rats exposed to simulated microgravity." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185927.
D'Asti, Esterina 1984. "Maternal dietary fat intake alters the neonatal stress response and metabolic profile in the offspring : participation of the endocannabinoid system?" Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111554.
Lu, Xiaodong, and n/a. "Contribution of the perirhinal cortex to the firing properties of hippocampal pyramidal neurons." University of Otago. Department of Psychology, 2007. http://adt.otago.ac.nz./public/adt-NZDU20080128.154906.
Sun, Bing, and 孫冰. "Vestibular influence on central cardiovascular regulation in the rat: functional and anatomical aspects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244774.
古永亮 and Wing-leung Marcel Koo. "The modulating action of verapamil on the gastric effects of cold-restraint stress in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31230891.
Heron, Marcia Indranee. "Effect of hyperthyroidism and hypothyroidism on coronary microvascular geometry in neonatal and adult rats." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9470.
Kong, Wuyi. "Absorption and distribution of epidermal growth factor in the gastrointestinal tract of suckling rats." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186231.
Insel, Nathan. "Physiology of the medial frontal cortex during decision-making in adult and senescent rats." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/196140.