Academic literature on the topic 'Rats Infertility'
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Journal articles on the topic "Rats Infertility"
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Harishankar, Nemani, Punjal Ravinder, K. Madhavan Nair, and Nappanveettil Giridharan. "Infertility in WNIN Obese Mutant Rats—Causes?" ISRN Endocrinology 2011 (December 15, 2011): 1–7. http://dx.doi.org/10.5402/2011/863403.
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We are maintaining two obese mutant rat strains (WNIN/Ob and WNIN/GR-Ob) in our animal facility since 1997. These rat colonies are perpetuated by crossing heterozygous littermates, since the obese phenotypes of both genders turned out be infertile. The present study revealed the reasons for this infertility. The male obese rats, though appeared normal in terms of sperm count, sperm motility and testis histology, however found wanting in terms of libido. This appeared to be due to low circulating testosterone levels seen in these animals, which should also account for low testis and accessory gland weights seen in them. The females exhibited delayed puberty, in terms of days taken for opening of vagina, irregular oestrus cycles and had small ovaries and short and stumpy uterine horns. The FSH peak observed in control lean animals during oestrus stage of the sexual cycle and also the E2 peak of normal oestrus cycle was conspicuously absent in these animals. They also showed elevated levels of progesterone throughout the sexual cycle. Thus the infertility seen in these mutants could be attributed to their abnormal gonadosteroid levels and the resulting anatomical and physiological defects.
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Colluoglu, Cagdas, Serdar Balci, Betul Gundogdu, Taha Abdulkadir Coban, Seval Bulut, and Halis Suleyman. "Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat." Bangladesh Journal of Pharmacology 17, no. 3 (September 6, 2022): 72–78. http://dx.doi.org/10.3329/bjp.v17i3.59418.
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This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.
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Gupta, Vijayalaxmi, Sheri A. Hild, Sudhakar R. Jakkaraj, Erick J. Carlson, Henry L. Wong, C. Leigh Allen, Gunda I. Georg, and Joseph S. Tash. "N-Butyldeoxygalactonojirimycin Induces Reversible Infertility in Male CD Rats." International Journal of Molecular Sciences 21, no. 1 (December 31, 2019): 301. http://dx.doi.org/10.3390/ijms21010301.
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This study shows for the first time that an iminosugar exerts anti-spermiogenic effect, inducing reversible infertility in a species that is not related to C57BL/6 male mice. In CD rats, N-butyldeoxygalactonojirimycin (NB-DGJ) caused reversible infertility at 150 mg/kg/day when administered daily as single oral dose. NB-DGJ inhibited CD rat-derived testicular β-glucosidase 2 (GBA2) activity at 10 µM but did not inhibit CD rat-derived testicular ceramide-specific glucosyltransferase (CGT) at doses up to 1000 µM. Pharmacokinetic studies revealed that sufficient plasma levels of NB-DGJ (50 µM) were achieved to inhibit the enzyme. Fertility was blocked after 35 days of treatment and reversed one week after termination of treatment. The rapid return of fertility indicates that the major effect of NB-DGJ may be epididymal rather than testicular. Collectively, our in vitro and in vivo studies in rats suggest that iminosugars should continue to be pursued as potential lead compounds for development of oral, non-hormonal male contraceptives. The study also adds evidence that GBA2, and not CGT, is the major target for the contraceptive effect of iminosugars.
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Altuner, Durdu, Mine Gulaboglu, Omer Erkan Yapca, and Nihal Cetin. "The Effect of Mirtazapine on Cisplatin-Induced Oxidative Damage and Infertility in Rat Ovaries." Scientific World Journal 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/327240.
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Cisplatin causes infertility due to ovarian toxicity. The toxicity mechanism is unknown, but evidence suggests oxidative stress. In this study, the effect of mirtazapine on cisplatin-induced infertility and oxidative stress in rats was investigated. 64 female rats were divided into 4 groups of 16. Except for the controls that received physiologic saline only, all were administered with cisplatin (5 mg/kg i.p.) and mirtazapine (15 mg/kg p.o.) or mirtazapine (30 mg/kg p.o.) for 10 days. After this period, six rats from each group were randomly selected, and malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), total gluthatione (tGSH), gluthatione peroxidase (GPx), superoxide dismutase (SOD), and 8-hydroxy-2 deoxyguanine (8-OH Gua) levels were measured in their ovarian tissues. Reproductive functions of the remaining rats were examined for 6 months. The MDA, MPO, NO groups and 8-OH Gua levels were higher in the cisplatin-treated groups than the controls, which was not observed in the mirtazapine and cisplatin groups. GSH, GPx, and SOD levels were reduced by cisplatin, which was prevented by mirtazapine. Cisplatin caused infertility by 70%. The infertility rates were, respectively, 40% and 10% for the 15 and 30 mg/kg mirtazapine administered groups. In conclusion, oxidative stress induced by cisplatin in the rat ovary tissue causes infertility in the female rats. Mirtazapine reverses this in a dose-dependent manner.
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Al-Alami, Zina M., Ziad A. Shraideh, and Mutasem O. Taha. "Rosmarinic acid reverses the effects of metronidazole-induced infertility in male albino rats." Reproduction, Fertility and Development 29, no. 10 (2017): 1910. http://dx.doi.org/10.1071/rd16174.
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Rosmarinic acid (RA) is a natural antioxidant that has many biological activities. In the present study we investigated the potential of RA to reverse the negative effects of the widely used antibiotic and antiprotozoal agent metronidazole (MTZ), which is known to induce reversible male infertility. Two doses of RA (5 and 15 mg kg–1) were studied in sexually mature rats with and without MTZ-induced infertility. Rats were intraperitoneally injected with 5 mg kg–1 RA or 15 mg kg–1 RA (in distilled water) and, 45 min later, they were intraperitoneally injected with 40 mg kg–1 MTZ (in distilled water). Cauda epididymidal sperm suspensions were used to assess sperm count, motility and morphology. Histological and ultrastructural studies were performed on the testes and cauda epididymidis. In rats in which infertility was not induced, neither dose of RA affected the parameters assessed. However, in sexually mature rats in which infertility was induced by 40 mg kg–1 MTZ, RA at both 5 and 15 mg kg–1 ameliorated the damaging effects of MTZ on final bodyweight (30 days later), sperm motility and morphology. Only 5 mg kg–1 RA, and not 15 mg kg–1 RA, improved the harmful effects of MTZ on the sperm count and testis ultrastructure. The findings of the present study have considerable clinical implications and suggest a possible use for RA to reverse the negative effects of MTZ on male fertility, the male reproductive system and spermatogenesis.
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Minabe, Shiori, Kinuyo Iwata, and Hitoshi Ozawa. "Effects of Diet-Induced Obesity on Hypothalamic Kisspeptin-Neurokinin-Dynorphin (KNDy) Neurons and Luteinizing Hormone Secretion in Sex Hormone-Primed Male and Female Rats." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A537. http://dx.doi.org/10.1210/jendso/bvab048.1094.
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Abstract Metabolic stress resulting from a nutrient excess causes infertility in both sexes. Kisspeptin-neurokinin B-dynorphin (KNDy) neurons in the arcuate nucleus (ARC) have been suggested to be key players in reproduction via direct stimulation of gonadotropin-releasing hormone (GnRH) and subsequent gonadotropin release in mammalian species. In this study, we investigated the sex differences in the effects of a high-fat diet (HFD) on KNDy-associated gene expression in the ARC to determine the pathogenic mechanism underlying obesity-induced infertility. Wistar-Imamichi strain male and female rats (7 weeks of age) were fed either a standard diet (10% calories from fat) or high-fat diet (45% calories from fat) for 4 months. In male rats, the HFD caused a significant suppression of Kiss1(encoding kisspeptin), Tac3(encoding neurokinin B), and Pdyn(encoding dynorphin A) gene expression in the ARC, resulting in a decrease in plasma luteinizing hormone (LH) levels. In female rats, 58% of the HFD-fed female rats exhibited irregular estrous cycles, while the other rats showed regular cycles. LH pulses were found, and the numbers of ARC Kiss1-,Tac3-, and Pdyn-expressing cells were high in control animals and almost allHFD-fed female rats, but two out of 10 rats showed profound HFD-induced suppression of LH pulse frequency and reduction in these cells. No statistical differences in LH secretion or ARC KNDy gene expression were observed between HFD-fed and control female rats. Additionally, the number of Gnrh1-expressing cells in the preoptic area was comparable between the groups in both sexes. Our findings revealed that HFD-fed male rats showed KNDy-dependent infertility, while irregular menstruation was mainly induced by KNDy-independent pathways during the incipient stage of obese infertility in female rats. Taken together, hypothalamic kisspeptin neurons in male rats may be susceptible to HFD-induced obesity compared with those in female rats.
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Oridupa, O. A., N. O. Ovwighose, O. O. Aina, and A. B. Saba. "Reversal of Diabetic Complications in Andrology Parameters of Alloxan-Induced Diabetic Male Wistar Rats Treated with Cleome rutidosperma Leaves." Folia Veterinaria 64, no. 1 (March 1, 2020): 19–26. http://dx.doi.org/10.2478/fv-2020-0003.
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AbstractMale infertility is one of the complications associated with diabetes mellitus. This study reported the effect of managing experimentally-induced diabetes in male Wistar rats with Cleome rutidosperma leaf extract at doses of 100 mg.kg−1, 200 mg.kg−1 or 400 mg.kg−1 for 14 days. Further deterioration or amelioration of reproductive derangement was assessed by changes in sperm morphology, sperm characteristics, and testicular histo-pathology. Andrology profile of diabetic untreated rats showed significant (P < 0.05) derangements compared to normoglycaemic rats. The profile of diabetic rats treated with the extract of C. rutidosperma, especially at the 200 mg.kg−1 dose showed a significant decrease in abnormal sperm cells, increases in sperm motility, live/ dead ratio and count compared to the untreated diabetic rats. Histopathology showed spermatogenic arrest and degeneration of Sertoli cells in the diabetic untreated rats, but was restored in the C. rutidosperma treated rats. This study showed evidence of infertility associated with diabetes and the ameliorative ability of C. rutidosperma on infertility demonstrated by improved andrological parameters. Traditional management of diabetes with C. rutidosperma leaves should therefore be encouraged in both humans and other animals, especially males with reproductive intentions.
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Jin, Zi-Run, Ya-Lei Cao, Zhi-Chao Luo, Qian-Cheng Zhao, Yu Xi, Jia-Ming Weng, Zhe Zhang, and Hui Jiang. "Therapeutic Effects of Xianlu Oral Solution on Rats with Oligoasthenozoospermia through Alleviating Apoptosis and Oxidative Stress." Evidence-Based Complementary and Alternative Medicine 2022 (June 18, 2022): 1–11. http://dx.doi.org/10.1155/2022/1269530.
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Idiopathic oligoasthenozoospermia (iOAZS) is one of the major causes of male infertility, and the ideal therapies for iOAZS have not been established yet. Traditional Chinese medicine (TCM), including Xianlu oral solution (XL), has been widely used as an adjunct treatment for male infertility in the clinic. However, the underlying mechanisms of XL treatment on iOAZS are still not known. Here, we found that XL treatment has therapeutic effects on ornidazole (ORN)-induced OAZS model rats through the amelioration of testis tissues spermatogenesis and the improvement of sperm concentration and motility. Moreover, XL treatment ameliorated the serum hormone levels, mitochondrial membrane potential, apoptosis status, and oxidative stress status in the testis tissues of iOAZS model rats. These findings identify a potential mechanism underlying the therapeutic effects of Xianlu oral solution on iOAZS, and Xianlu oral solution may be used as a traditional Chinese medicine (TCM) therapy for male infertility caused by iOAZS in clinical practice.
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Woodside, Barbara, Alfonso Abizaid, and Shelina Jafferali. "Effect of acute food deprivation on lactational infertility in rats is reduced by leptin administration." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 6 (June 1, 1998): R1653—R1658. http://dx.doi.org/10.1152/ajpregu.1998.274.6.r1653.
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The goals of these experiments were to determine whether lactational anestrus would be prolonged by a 48-h fast at days 13 and 14 postpartum (pp) and, if so, to determine whether this effect could be reversed by treatment with the Ob protein leptin. We found that food deprivation on days 13 and 14 pp prolonged lactational infertility by 7 days and that the nutritional experience of both the dam and her litter contributed to this effect. Leptin administration (2.5 mg ⋅ kg−1 ⋅ day−1) during food deprivation was sufficient to reduce the length of lactational infertility compared with vehicle-treated food-deprived rats ( P < 0.05). Similar leptin treatment in ad libitum-fed animals reduced food intake ( P < 0.05) and litter growth ( P < 0.05) but had no statistically significant effect on maternal weight gain or length of lactational infertility. Food-deprived lactating animals had lower circulating leptin levels than ad libitum-fed lactating animals on day 15 pp ( P < 0.05), as determined by RIA. Levels in nonlactating rats were higher than in either lactating group ( P < 0.05).
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Al-Rawaf, Hadeel A., Sami A. Gabr, and Ahmad H. Alghadir. "The Potential Role of Circulating MicroRNAs in Male Rat Infertility Treated with Kaempferia parviflora." Evidence-Based Complementary and Alternative Medicine 2021 (December 17, 2021): 1–14. http://dx.doi.org/10.1155/2021/9622494.
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Background. Therapeutic strategies based on herbal plants and diets containing sufficient amounts of antioxidants and essential vitamins are very important factors in treating reproduction and male infertility worldwide. Thus, the aim of this study was to investigate the potential effects of Kaempferia parviflora (KP) on the role of some microRNAs in treated and nontreated infertile rats. In addition, the correlation of expressed microRNAs with sperm count, sperm motility, and sperm viability was identified. The probable use of these microRNAs as a diagnostic marker for predicting the clinical response of infertility to the treatment with KP was also achieved. Methods. In the present study, the potential effects of Kaempferia parviflora (KP) at different doses (140, 280, and 420 mg/kg) for six weeks on male rats with subinfertility were explored. In addition, the effect of KP on the expression of circulating microRNAs and its correlation with the parameters of sexual infertility was identified by performing both in vitro and in vivo assays. In vitro antioxidant activity, sperm functional analysis, serum testosterone, and expression of circulating microRNAs were conducted using colorimetric, ELISA, and real-time RT-PCR analysis, respectively. Results. Kaempferia parviflora (KP) at nontoxic doses of 140–420 mg/kg/day for six weeks significantly improved serum testosterone and epididymal sperm parameters (sperm count, motility, and sperm viability), increased testicular weight, and provided a reduction in the percentage of abnormal spermatozoon in infertile male rats. The expression of miR-328 and miR-19b significantly decreased, and miR-34 significantly increased in infertile rats treated with KP compared to infertile nontreated rats. After six weeks of KP therapy, the change in the expression levels of miRNAs was correlated positively with higher levels of serum testosterone and the measures of epididymal sperm parameters. The respective area under the receiver operating characteristic curve (AUC-ROC) was applied to predict the potential use of miR-328, miR-19b, and miR-34 in the diagnosis of male infertility in treated and nontreated infertile male rats. The data showed that AUC cutoff values of 0.91 for miR-328, 0.89 for miR-19b, and 0.86 for miR34 were the best estimated values for the clinical diagnosis of male rats with infertility. In rats treated with KP for six weeks, AUC cutoff values of 0.76 for miR-328, 0.79 for miR-19b, and 0.81 for miR-34 were the best cutoff values reported for the clinical response of infertility to KP therapy after six weeks. Conclusions. In this study, the improvement of male infertility might proceed via antioxidant and antiapoptotic pathways, which significantly improve spermatogenesis and aphrodisiac properties of males. In addition, the expression of miRNAs, miR-328, miR-34, and miR-19b, in KP-treated and nontreated infertile rats significantly correlated with increased serum testosterone levels and epididymal sperm parameters as well. MicroRNAs, miR-328, miR-34, and miR-19b, might be related to oxidative and apoptotic pathways that proceeded in spermatogenesis. Thus, the use of miRNAs could have a role as diagnostic, therapeutic, and predictive markers for assessing the clinical response of Kaempferia parviflora treatment for six weeks. This may have potential applications in the therapeutic strategies based on herbal plants for male infertility. However, in subsequent studies, the genetic regulatory mechanisms of the expressed miRNAs should be fully characterized.
Dissertations / Theses on the topic "Rats Infertility"
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Pontes, Davi Abeid. "Avaliação dos mecanismos causadores de disturbios reprodutivos em ratos diabeticos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318038.
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Orientador: Wilma de Grava KempinasDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O Diabetes mellitus geralmente se associa a algum tipo de disfunção sexual, provocando infertilidade, tanto em seres humanos, quanto em animais experimentais. Em trabalho anterior realizado em nosso laboratório, ratos machos que tiveram hiperglicemia induzida quimicamente pela administração de streptozotocin apresentaram diminuição da fertilidade através de múltiplos parâmetros analisados. O presente estudo teve como objetivo investigar os mecanismos envolvidos e o papel da testosterona no processo. Para tanto, ratos machos foram divididos em 3 grupos experimentais: normoglicêmico (controle), hiperglicêmico (streptozotocin), e hiperglicêmico com reposição hormonal (streptozotocin+testosterona) e foram avaliados parâmetros reprodutivos e espermáticos, níveis hormonais, a contratilidade do ducto deferente isolado in vitro, comportamento sexual e o número de espermatozóides ejaculados no útero. O ducto deferente de animais diabéticos apresentou um quadro de hipersensibilidade à metoxamina, um agonista sintético de adrenoceptores _1. Estes mesmos animais apresentaram os seguintes resultados: alteração de comportamento sexual e ausência de espermatozóides ejaculados, redução dos níveis plasmáticos de testosterona, perda de peso corpóreo e de órgãos como epidídimo, ducto deferente, vesículas seminais e próstata ventral, perda de células germinativas na luz e desorganização epitelial aparente em túbulos seminíferos, além da aceleração do tempo de trânsito dos espermatozóides pelo epidídimo. Os dados apresentados neste trabalho indicam que os mecanismos responsáveis pela perda de fertilidade natural de ratos diabéticos envolvem comprometimento do processo espermatogênico, assim como desregulação do eixo reprodutivo masculino, juntamente com evidências para problemas no processo de maturação espermática, tendo como fator complicante o prejuízo da função ejaculatória, dependente da contratilidade da musculatura lisa dos ductos deferentes. A reposição de andrógeno não foi totalmente capaz de reverter os danos causados pelo diabetes no sistema reprodutivo masculino de ratos adultos
Abstract: Diabetes mellitus is usually related with some kind of sexual dysfunction, promoting infertility in humans as well as in experimental models. In a prior work from our laboratory, male rats, which had a diabetic-induced state of hyperglycemia caused by streptozotocin administration, demonstrated reduced fertility through several parameters analyzed. The present study aimed at investigating the mechanisms involved and the role of testosterone in the process. Male rats were randomly allocated in 3 experimental groups: control, hyperglycemic (streptozotocin), and hyperglycemic with hormone replacement (streptozotocin+testosterone) and the following parameters were analyzed: reproductive and spermatic parameters, hormone levels, sexual behavior, contractility of vas deferens in vitro, sexual behavior parameters and the number of sperm ejaculated in utero. The vas deferens of diabetic animals was hypersensitive to methoxamine, a synthetic agonist of _1 adrenoceptors. The same animals showed the following results: alterations in sexual behavior and lack of sperm ejaculated, reduction in plasma testosterone levels, decreased body weight and epididymis, seminal vesicles, ventral prostate and vas deferens weights, loss of germ cells in the lumen and apparent epithelial disarrange in seminiferous tubules, and accelerated sperm transit time in the epididymis. The data presented herein indicate that the mechanisms underlying the reduced fertility through natural mating observed in diabetic rats involve impairment of the spermatogenic process, as well as a dysregulation of the male reproductive axis, together with evidence for problems in the sperm maturation process, which has as a complicant factor the impairment of the ejaculatory function, dependent on the vas deferens smooth muscle contractility. Androgen replacement was not totally capable of reversing the damage caused by diabetes on the male reproductive system of adult rats
Mestrado
Biologia Celular
Mestre em Biologia Celular e Estrutural
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Adedeji, Adekunle. "The Combined Effects of Leptin and Coenzyme Q10 in Ameliorating Obesity- Induced Infertility in Female Rats." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3131.
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Infertility is one of the major problems of obesity. Studies have shown that administration of leptin reversed obesity-induced infertility in rats and mice. Coenzyme Q10 (CoQ10) is an antioxidant and also supplies the energy needed for ovulation and embryo development. We hypothesized that leptin when combined with CoQ10 could greatly improve obesity-induced infertility. The results showed a significant decrease in food intake, body weight, and the regular estrous cycle was restored after treatment with leptin+CoQ10. There was a significant increase (p10 significantly (p10 can improve fertility in obese infertile female rats. This study could provide a novel therapeutic strategy for the treatment of infertility and formulation of new drugs for the treatment of obesity-induced infertility in females.
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Adedeji, Adekunle, Effiong Ottukonyong, Jonathan M. Peterson, and W. Andrew Clark. "The Combined Effects of Leptin And Coenzyme Q10 in Ameliorating Obesity-Induced Infertility in Female Rats." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2513.
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Infertility is one of the major complications of obesity. Studies have shown that administration of leptin modulated the expression of Β-catenin in the ovary and reversed obesity-induced infertility in rats. Coenzyme Q10 (CoQ10), an antioxidant, supplies the energy used for ovulation, oocyte and embryo development and prevents DNA damage that causes infertility. We hypothesized that leptin when combined with CoQ10 could greatly improve fertility. Twenty-one female Sprague-Dawley rats were used in this study and divided into five treatments groups. Group I rats was fed rat chow diet (RCD) while groups II to V were fed High-fat diet (HFD) for 14 weeks to induce infertility. Group 1 RCD and group II HFD control rats received 1 ml of saline intraperitoneally (i.p.) twice daily for 2 days, group III HFD rats received 1 ml of 100 µg of leptin i.p. twice daily for 2 days, group IV HFD rats received 10 mg/kg of CoQ10 i.p. for 2 weeks plus saline twice daily for 2 days. Group V HFD rats received 1 ml of 100 µg of leptin i.p. twice daily for 2 days plus 10 mg/kg of CoQ1o i.p. for 2 weeks. Estrous cycle was checked daily and food intake and body weight measured twice weekly before and after treatments. Fourteen days post treatment, all the animals were sacrificed. The blood and tissues were collected for analysis. The results show a significant decrease in food intake and body weight and regular estrous cycle restored in groups III and V rats. There was significant (p < 0.05) increase in spleen weight in groups IV and V. FSH level increased significantly (p < 0.05) in the leptin plus CoQ10 treated group while CoQ10 level was increased significantly (p < 0.05) in the leptin-treated group. Β-catenin expression was decreased in group IV and V, suggesting that Β-catenin expression may be downregulated by COQ10 administration. These results indicate that synergistic action of leptin and CoQ10 could delay the onset of obesity-induced infertility exhibited by the reduction of food intake and body weight. In conclusion, combinations of CoQ10 with leptin can improve fertility in obese infertile female rats and could provide a novel therapeutic strategy for the treatment of female infertility.
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Sokan, Olufunke A. "Systemic Leptin Modulates the Expression of E-cadherin, β-catenin in the Ovary of Dietary-Induced Obese Infertile Rats." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1174.
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One of the numerous complications of obesity is infertility. Leptin has been shown to reverse infertility; however, exact mechanism is poorly understood. Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced obese infertile rats to reverse infertility. Female Sprague-Dawley rats were fed either regular chow diet (RCD) (n=6) or high fat diet (HFD) (n=14). Oestrus cycles were monitored daily until their cycles became irregular. 100 ug/ml of leptin was given intraperitoneally to HFD-fed rats (n=5) with irregular cycles. The control rats HFD (n=9) and RCD received saline. Leptin treatment restored regular estrous cycle and increased the expression of E-cadherin and β-catenin in all the 5 rats (HFD+Leptin). This could represent the mechanism by which leptin reverses infertility in obese infertile rats.
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Jordaan, Audrey Emmerentia. "The effects of the wild african potato (hypoxis hemerocallidea) supplementation on streptozotocin-induced diabetic wistar rats reproductive function." Thesis, Cape Peninsula University of Technology, 2015. http://hdl.handle.net/20.500.11838/2234.
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Thesis (MTech (Biomedical Technology))--Cape Peninsula University of Technology, 2015.Diabetes mellitus (DM) has been reported to be one of the greatest global public health threats. Statistics of the fertility status of modern society has linked increased DM to a decrease in fertility rates. Hyperglycaemia is characteristic of DM that results in a disturbance of proteins, lipids and carbohydrate metabolism leading to an increase production of reactive oxygen species (ROS). In the case where ROS overwhelms antioxidant mechanisms, the body goes into state of oxidative stress (OS). OS plays a vital role in the progression of DM which leads to dysfunction and damage of various organs including that of the reproductive system. Os has shown to cause damage to the sperm membraneby oxidation of polyunsaturated fatty acids (PUFA’s) as the sperm membrane are rich in PUFA’s. This damage contributes to reduced sperm motility, concentration, morphological abnormalities and the sperms ability to fuse with the ZP of the oocyte. DM has been observed to cause testicular degeneration by interrupting sertoli cell production and maintenance thus resulting in a disturbance of the normal functioning of the reproductive system. Experimental studies have targeted more natural sources for treating DM and its complications of the reproductive system. Plants and natural dietary substances have shown to have high antioxidant contents that combat DM induced oxidative stress. This study explored the effect the Hypoxis hemerocallidea (H. hemerocallidea) supplementation on testicular and epididymal tissue, sperm motility and reproductive hormones in male wistar rats. The experiment were conducted for 6 weeks and the rats (230-260 grams) were randomly divided into 5 groups (n=12 per group). Diabetes was induced in 3 of the 5 groups. The first group was the normal control group (A), second the diabetic control group (B), third was the diabetic group treated with 800mg/kg H. hemerocallidea (group C), fourth the diabetic group treated with 200mg/kg H. hemerocallidea (group D) and fifth the non-diabetic group supplemented with 800mg/kg H. hemerocallidea (group E). Blood glucose showed a significant increase in the diabetic group when compared to the normal control and treated groups. H. hemerocallidea showed improvement in sperm motility and sperm morphology more at 800mg/kg when compared to diabetic group and diabetic group treated with 200mg/kg. Body, testicular and epipidymal weights of diabetic control were significantly lower when compared to the other groups. Testicular and epididymal Malondialdehyde levels were decreased in normal control, diabetic groups treated with different doses of H. hemerocallidea and the non-diabetic group supplemented with H. hemerocallideaon comparing with the diabetic control group. Antioxidants such as Superoxide dismutase, Catalase and total Glutathione activity was observed to be dosage dependent in certin groups but most showed a significant increase when compared to the diabetic control group. The total antioxidant capacity was measured using Oxygen radical absorbance capacity (ORAC) and Ferric ion reducing antioxidant power (FRAP); increase was observed when normal control group and treated groups were compared to the diabetic group. Testosterone and estradiol levels were also increased when the normal control group and treated groups were compared to the diabetic control group. Based on our findings it can be concluded that H. hemerocallidea supplementation can potentially be used to counteract deleterious effects of DM on the male reproductive system.
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Costa, Vinícius Moreira Gonçalves. "Avaliação reprodutiva de ratas superalimentadas na infância expostas a diferentes tipos de treinamento físico." Universidade Federal de Juiz de Fora (UFJF), 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/6629.
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Os dados estatísticos de prevalência e incidência de sobrepeso/obesidade vem aumetando ao longo dos anos e atinge milhões de pessoas ao redor do mundo, tornando-se assim, umas das grandes epidemias do século XXI. A globalização e o aumento na disponibilidade de alimentos mais palatáveis e ricos em gordura saturada, somados ao estilo de vida sedentário, contribuem diretamente no desenvolvimento dessa condição. Estudos demonstram que alterações nutricionais durante fases críticas do desenvolvimento infantil, como a lactação, estão associadas ao desenvolvimento de obesidade, alterações metabólicas, doenças cardiovasculares, problemas respiratórios e diabetes. Além disso, o sobrepeso/obesidade pode influenciar na função reprodutiva da população, gerando malformações fetais, infertilidade, assim como morte materna e fetal. Considerando o exercício físico como fator primário no combate ao sobrepeso/obesidade, pretendeu-se avaliar se o exercício físico, em diferentes intensidades, é capaz de influenciar na saúde reprodutiva de indivíduos com sobrepeso/obesos. Foram utilizadas 40 ratas Wistar provenientes de ninhadas padrão (NP=10 filhotes/mãe) e de ninhadas reduzidas (NR=4 filhotes/mãe) que promoveram o sobrepeso/obesidade. Os animais foram treinados durante oito semanas em protocolos de intensidade moderada (Endurance) e intervalar de alta intensidade (Hiit), acasalados aos 90 dias de vida e eutanasiados no 20o dia de gestação. As variáveis metabólicas, bioquímicas e reprodutivas foram coletadas e analisadas. Os animais dos grupos superalimentados treinados Endurance e Hiit apresentaram redução significativa das médias de peso, consumo, índice de tolerância à insulina e de determinados parâmetros bioquímicos e reprodutivos analisados quando comparados com o grupo superalimentado sedentário. Porém, não houve diferenças significativas com relação ao comprimento nasoanal; peso relativos de órgãos; gorduras retroperitoneal e perigonadal; além do teste de tolerância oral à glicose; índices de gestação, implantação e reabsorção fetal; e demais análises fetais nos grupos estudados. Concluiu-se que o treinamento físico, em suas diferentes intensidades, não foi capaz de melhorar significativemente a capacidade reprodutiva desses animais, entretanto, foi eficiente em promover redução do peso, consumo, sensibilidade à insulina e de determinados parâmetros bioquímicos de animais superalimentados durante a fase lactente. Além disso, o exercício Endurance se mostrou mais eficiente no controle das variáveis descritas acima, quando comparado ao exercício Hiit.
Statistical data of incidence and prevalence of Overweight/obesity have been growing over the years and this condition affects millions of people around the world, making it one of the great epidemics of the 21th century. Globalization and the increase in the availability of more palatable foods rich in saturated fat, added to the sedentary lifestyle, contribute directly to the development of this condition. Studies show that nutritional changes during critical stages of childhood development, such as lactation, are associated with the development of obesity, metabolic disorders, cardiovascular diseases, respiratory problems and diabetes. In addition, overweight/obesity can influence the reproductive function of the population causing fetal malformations, infertility, as well as maternal and fetal death. Considering physical exercise as a primary factor against overweight / obesity, we intend to evaluate whether physical exercise, in different intensities, is capable of influencing the reproductive health of overweight/obese individuals. Forty Wistar rats from normal litters (NL = 10) and small litters (SL = 4) were used and overweight/obesity was induced by litter reduction. The animals were trained for 8 weeks in protocols (Endurance and Hiit), mated at 90 days of age and euthanized on the 20th day of gestation. Metabolic, biochemical and reproductive datas were collected and analyzed. The animals of the overfeed groups trained Endurance and Hiit showed reduction with significant differences in body weight, consumption, insulin tolerance test and in some biochemical e reproductive parameters analyzed when compared to the control groups. However, there were no significant differences regarding nasoanal distance, relative organ weight, retroperitoneal and perigonadal fats, as well as oral glucose tolerance test, gestation index, implantation and fetal resorption in the studied groups. It was concluded that the physical training, in its different intensities, was not able to improve significantly the reproductive capacity of these animals, however, it was efficient to promote weight reduction, consumption, insulin sensitivity and certain biochemical parameters of supercharged animals during the phase. In addition, the Endurance exercise was more efficient in controlling the variables, described above, when compared to the Hiit exercise.
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Peronace, Laura A. "Two-part investigation of the biopsychosocial model in male reproductive health : A cross-sectional investigation of the association between infertility diagnosis and emotional distress in men (Part I) ; and, A prospective controlled investigation of the effect of psychosocial stress on corticosterone, testosterone and sperm parameters in male rats (Part II)." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54630/.
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This thesis explored the interactions between psychological well-being and male fertility using the biopsychosocial model. The biopsychosocial model proposes that biological, psychological, and social processes interact and impact on health. These interrelationships were investigated in a sample of men undergoing fertility treatment and in a set of experiments using an animal model of stress. It is commonly thought that men with male factor infertility suffer more compared to men in couples with other infertility diagnoses, mainly due to the social stigma attached to being a man unable to father. The inter-relationships among diagnosis, psychological stress, and social environment were examined in men during a twelve month period of fertility treatment. It was found that men, regardless of diagnosis, showed signs of suffering over time and perceived some deterioration in their social environment that was at least partly caused by their psychological well-being at the start of treatment. To better understand how stress and reproductive processes interact, an animal stressor paradigm was developed. Male rats were exposed to a psychosocial cage change stressor (PCCS) where housing alternated every day between being alone, or in a new combination of two or three rats per cage for either 12 or 24 days. The four experiments showed that exposure to PCCS induced a mild physical stress response and consistent effects on reproductive parameters. It was concluded that the psychological and social aspects of the PCCS each have an impact on reproduction. This thesis has provided evidence of biopsychosocial links in the reproductive context supporting a biopsychosocial model of male fertility.
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MIYAKE, KOJI, SATOSHI KATSUNO, HATSUKI HIBI, and MASANORI YAMAMOTO. "ANTIBIOTIC AND EJACULATION TREATMENTS IMPROVE RESOLUTION RATE OF LEUKOCYTOSPERMIA IN INFERTILE MEN WITH PROSTATITIS." Nagoya University School of Medicine, 1995. http://hdl.handle.net/2237/16082.
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Eggert, Jan. "Epidemiological and clinical aspects of fertility and diseases associated with infertility among Swedish-born and foreign-born women /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7140-814-3/.
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Idahl, Annika. "Chlamydia trachomatis as a risk factor for infertility in women and men, and ovarian tumor development." Doctoral thesis, Umeå universitet, Obstetrik och gynekologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22239.
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Background: Chlamydia trachomatis in women is a risk factor for tubal factor infertility and extra uterine pregnancies, but the impact of a C. trachomatis infection on male fertility is unclear. It is also hypothesized that persistent infection with C. trachomatis, or other microorganisms, might initiate/promote ovarian tumor development. The aims of the thesis were to study whether C. trachomatis serum antibodies in women and men had an impact on infertility diagnoses, semen characteristics, pregnancy rates and pregnancy outcomes; furthermore, to explore associations of C. trachomatis, and Mycoplasma genitalium, plasma antibodies with epithelial ovarian cancer and borderline ovarian tumors, as well as the presence of C. trachomatis bacteria, and other microorganisms, in ovarian tissues. Materials and methods: Papers I and II: 244/226 infertile couples were tested for serum C. trachomatis IgG, IgA, IgM and chlamydial Heat Shock Protein 60 (cHSP60) IgG antibodies. C. trachomatis IgG positive couples were also tested for C. trachomatis DNA in a urine sample. The follow-up period was 14-54 months. 244 spontaneously pregnant women were also tested for serum C. trachomatis IgG antibodies. Papers III and IV: Plasma samples from 291 women with epithelial ovarian cancer, borderline ovarian tumors and benign conditions, and plasma samples from 271 healthy controls, were analyzed for C. trachomatis IgG, IgA and cHSP60-1 IgG and M. genitalium IgG antibodies. Ovarian tissues from 186 women with benign ovaries, borderline ovarian tumors and epithelial ovarian cancer, as well as tissues from the contra lateral ovary in 126 women, were analyzed for the presence of C. trachomatis, M. genitalium, Neisseria gonorrhoeae, HPV and the polyoma viruses BKV and JCV with nucleic acid amplification tests. Results: Papers I and II: The prevalence of C. trachomatis IgG antibodies was higher among infertile than fertile women, and there were 9 couples with ongoing C. trachomatis infections. In men, C. trachomatis IgG and IgA antibodies were associated with a reduced likelihood to achieve pregnancy for the couple, as well as lower sperm concentration, reduced sperm motility and vitality, increased teratozoospermia index and the occurrence of leukocytes. C. trachomatis IgG and cHSP60 IgG antibodies in infertile women were associated with tubal factor infertility, but not with reduced pregnancy rates or outcomes. Paper III: cHSP60-1 IgG antibodies were associated with ovarian cancer belonging to the postulated type II pathogenetic pathway when plasma samples obtained more than one year prior to diagnosis were analyzed. M. genitalium IgG antibodies were associated with borderline ovarian tumors; however a statistical type 1 error cannot be excluded. Paper IV: None of the microorganisms studied were found in the ovarian tissue samples. Conclusions: C. trachomatis IgG and IgA antibodies in the man substantially decreases the chances of the infertile couple to achieve pregnancy, and are associated with subtle negative changes in semen characteristics. C. trachomatis IgG and cHSP60 IgG antibodies in the woman are risk factors for tubal factor infertility. Prospective plasma cHSP60-1 IgG antibodies are associated with type II ovarian carcinomas, but C. trachomatis bacteria, or the other microorganisms studied, could not be detected in benign, borderline or malignant ovarian tissues.
Books on the topic "Rats Infertility"
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1953-, Harris Grace, and Roberts Chloe, eds. Fertility research trends. New York: Nova Science, 2008.
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How to improve your ART success rates: An evidence-based review of adjuncts to IVF. Cambridge: Cambridge University Press, 2011.
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Kayes, Oliver, and Akwasi Amoako. Infertility. Edited by David John Ralph. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0098.
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Surgical sperm retrieval combined with the advent of in vitro fertilization and intracytoplasmic sperm injection has enabled many men with obstructive and non-obstructive azoospermia to father their own biological children. Several sperm retrieval techniques have been described to obtain sperm from the vas deferens, epididymis, and testicular parenchyma for use in assisted reproduction technologies. The current techniques have variable success rates but have not been subjected to randomized control trials hence the paucity of good evidence to inform the choice of one technique over the others. In experienced hands, sufficient and good quality sperm can usually be harvested for treatment and/or cryopreservation. This chapter summarizes the current techniques of surgical sperm retrieval, sperm retrieval success rate, and the role of adjuvant therapies in increasing chance of successful sperm retrieval.
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Reisman, Yacov. Infertility. Edited by David John Ralph. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0099.
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Vasectomy is now well recognized worldwide as one of the safest and most effective contraceptive methods. A history should be taken and an examination should be carried out on every person requesting sterilization. Preoperative counselling should include alternative methods of contraception, complication and failure rates, and the need for postoperative semen analysis. There are no absolute contraindications to sterilization, provided that they make the request themselves, are of sound mind, and are not acting under external duress. Relative contraindications may be the absence of children, age <30 years, severe illness, no current relationship, and scrotal pain. Although various vasectomy techniques have been described, all share three essential steps: isolation of the vas deferens, delivery and interruption of the vas, and management of the vasal ends.
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Simón, Carlos, and Carmen Rubio. Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health. Taylor & Francis Group, 2017.
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Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health. Taylor & Francis Group, 2018.
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Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health. Taylor & Francis Group, 2017.
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Simón, Carlos, and Carmen Rubio. Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health. Taylor & Francis Group, 2017.
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Simón, Carlos, and Carmen Rubio. Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health. Taylor & Francis Group, 2017.
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Simón, Carlos, and Carmen Rubio. Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine: Improving Patient Success Rates and Infant Health. Taylor & Francis Group, 2017.
Find full textBook chapters on the topic "Rats Infertility"
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Matteo, Maria. "Assisted Reproductive Technology." In Practical Clinical Andrology, 237–50. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-11701-5_18.
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AbstractThe human species is biologically distinguished by low fertility. In fact, with each menstrual cycle, a couple at the peak of their reproductive capacity has only about a 30% chance of conceiving. The WHO states infertility as “a disease of the reproductive system defined by the failure to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse.”Assisted reproductive technology (ART) consists of all treatments or procedures that include the in vitro handling of both human oocytes and sperm or of embryos, for the purpose of establishing a pregnancy.The techniques are usually divided into three broad categories: First level techniques: Intrauterine and Intracervical Insemination (IUI/ICI), the simpler and less invasive ones, such as intrauterine insemination (IUI) with or without Intracervical Insemination (ICI) ovarian stimulation. Second level techniques: the more complex and more invasive ones that can be performed under local anesthesia or deep sedation, which differ from the basic techniques as they involve manipulation of female and male gametes and because they require in vitro fertilization. Among these techniques the IVF (In Vitro Fertilization and Embryo Transfer), ICSI (Intracytoplasmic Sperm Injection), and the possible cryopreservation of male and female gametes and embryos. Third level techniques procedures that require general anesthesia with intubation, including: laparoscopic egg retrieval, intra-tubal transfer of male and female gametes (GIFT), zygotes (ZIFT) and /or embryos (TET) laparoscopically; microsurgical sampling of gametes from the testicle: Testicular Sperm Extraction (TESE), Microsurgical Testicular Sperm Extraction (microTESE), Testicular Sperm Aspiration (TESA); microsurgical sampling of gametes from the epididymides: Percutaneous Epididymal Sperm Aspiration (PESA) and Microsurgical Epididymal Sperm Aspiration (MESA). In all assisted reproduction techniques, the seminal fluid receives a treatment able to induce capacitation “in vitro” so that the activated spermatozoa, at the threshold of the acrosomal reaction, can interact with the mature oocytes. Preimplantation Genetic Screening (PGS) and Preimplantation Genetic Diagnosis (PGD) are highly specialized procedures which involve removing three to four cells from a 5–6 day old blastocyst and testing them for chromosomal abnormalities prior to transferring the embryo into a woman’s uterus. According to data reported from the European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), the clinical pregnancy rates (PR) per aspiration and per transfer are 28.0% and 34.8%, respectively. After ICSI, the corresponding rates are 24% and 33.5%. ART can alleviate the burden of infertility on individuals and families, but it can also present challenges to public health as evidenced by the high rates of multiple delivery, preterm delivery, and low birth-weight delivery experienced with ART.
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Bennett, Nigel C., Chris G. Faulkes, and Jennifer U. M. Jarvis. "Socially Induced Infertility, Incest Avoidance and the Monopoly of Reproduction in Cooperatively Breeding African Mole-Rats, Family Bathyergidae." In Advances in the Study of Behavior, 75–114. Elsevier, 1999. http://dx.doi.org/10.1016/s0065-3454(08)60216-8.
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Patil, Madhuri. "Enhancing IUI Success Rates." In Insights into Infertility Management, 170. Jaypee Brothers Medical Publishers (P) Ltd., 2012. http://dx.doi.org/10.5005/jp/books/11495_18.
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Badroo, Irfan Ashraf, Ashiq Hussain Khanday, Suriya Ashraf Badroo, Saba Khursheed Khan, Irshad Aziz Malik, Hemlata Pradeep Nandurkar, and Syed A. Untoo. "Effects on Fertility and Reproductive Behavior From Environmental Contaminants in Extreme Environments." In Research Anthology on Advancements in Women's Health and Reproductive Rights, 556–75. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-6299-7.ch030.
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Human infertility is increasing at an alarming rate and has affected nearly 12% of reproductive aged couples worldwide. Various reasons have been linked to its cause, besides the age of female partner, a huge number of environmental contaminants produced and used by humans throughout the world are one of the reasons for growing the infertility rate. Their exposure is virtually unavoidable. The literature review provides an overview regarding the effect of chemical agents on fertility. The environmental contaminants included in this review are plastics, pesticides, phthalates, metals, industrial chemicals, endocrine disrupters, and nano materials. The goal is to discuss the association between environmental contaminants and reproductive disorders with particular emphasis on infertility.
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Badroo, Irfan Ashraf, Ashiq Hussain Khanday, Suriya Ashraf Badroo, Saba Khursheed Khan, Irshad Aziz Malik, Hemlata Pradeep Nandurkar, and Syed A. Untoo. "Effects on Fertility and Reproductive Behavior From Environmental Contaminants in Extreme Environments." In Climate Change and Its Impact on Fertility, 206–25. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4480-8.ch010.
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Human infertility is increasing at an alarming rate and has affected nearly 12% of reproductive aged couples worldwide. Various reasons have been linked to its cause, besides the age of female partner, a huge number of environmental contaminants produced and used by humans throughout the world are one of the reasons for growing the infertility rate. Their exposure is virtually unavoidable. The literature review provides an overview regarding the effect of chemical agents on fertility. The environmental contaminants included in this review are plastics, pesticides, phthalates, metals, industrial chemicals, endocrine disrupters, and nano materials. The goal is to discuss the association between environmental contaminants and reproductive disorders with particular emphasis on infertility.
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Badroo, Irfan Ashraf, Ashiq Hussain Khanday, Suriya Ashraf Badroo, Saba Khursheed Khan, Irshad Aziz Malik, Hemlata Pradeep Nandurkar, and Syed A. Untoo. "Effects on Fertility and Reproductive Behavior From Environmental Contaminants in Extreme Environments." In Climate Change and Its Impact on Fertility, 206–25. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4480-8.ch010.
Full textAbstract:
Human infertility is increasing at an alarming rate and has affected nearly 12% of reproductive aged couples worldwide. Various reasons have been linked to its cause, besides the age of female partner, a huge number of environmental contaminants produced and used by humans throughout the world are one of the reasons for growing the infertility rate. Their exposure is virtually unavoidable. The literature review provides an overview regarding the effect of chemical agents on fertility. The environmental contaminants included in this review are plastics, pesticides, phthalates, metals, industrial chemicals, endocrine disrupters, and nano materials. The goal is to discuss the association between environmental contaminants and reproductive disorders with particular emphasis on infertility.
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Niu, Xiangli, Hua Huang, Yi Mo, Yan Sun, and Weihua Wang. "A Method for Small Number of Human Sperm Cryopreservation." In Infertility and Assisted Reproduction [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98674.
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Recently, some sperm vitrification devices were developed to simplify the procedures to freeze small number of human sperm. In the present study, we used these devices to further examine some factors that affect sperm motility after fast freezing. Experiments were designed to examine the effects of 1) direct immersion of the devices to liquid nitrogen and indirect immersion of the devices to liquid nitrogen in which the devices were sealed in cryogenic storage vials; 2) different freezing volumes (1–5 μl); 3) different equilibration times (1–5 min); and 4) different ratio of freezing solution (0,1-5,1) on post thawing sperm motility. It was found that fast sperm freezing in the sealed vials had high post thawing sperm motility (91.3–93.7% of recovered sperm motility rates) while direct immersion of the devices to liquid nitrogen had 0% post thawing sperm motility. No differences in the recovered sperm motility rates were observed between different freezing solution volumes (87.4–90.5%), different equilibration times (89.5–94.0%), and different freezing solution ratios (90.8–94.6%). However, only 6.8% of recovered sperm motility rate was obtained if sperm were frozen in the medium without sperm freezing solution. These results indicate that human sperm can be rapidly frozen after the devices are sealed in the vials with different equilibration time in the medium containing sperm freezing solution. High post thawing sperm motility can be recovered with this method so that ~90% of sperm are usable after freezing.
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Luis Giraldo Moreno, Juan, and Susana Salazar López. "Fibroids and Infertility." In Infertility and Assisted Reproduction [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98402.
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Uterine fibroids (also known as leiomyomas or myomas) are the most common pelvic tumors, affecting more than 70% of women over 70 years of age and although most are asymptomatic, some women may experience symptoms, depending on their location and size, which can alter your quality of life, such as abnormal uterine bleeding, anemia, pelvic pain and pressure, dyspareunia, increased urinary frequency and constipation. Its relationship with infertility has been controversial and, although insignificant for subserous fibroids, it appears that submucosal and intramural fibroids that distort the endometrial cavity can affect embryo implantation and are associated with an increased risk of early pregnancy loss. Its treatment will depend on the patient’s symptoms, size, location, whether it is one or multiple, and whether or not she suffers from infertility. It is clear that submucosal fibroids have a negative impact on fertility and with respect to intramural fibroids it is known that fibroids larger than 4 cm alter the probability of pregnancy, however there are studies that show that even smaller or multiple fibroids could affect pregnancy rates. There are multiple options for the treatment of fibroids; however, patients who are candidates for expectant, medical or surgical management should be individualized, and especially if they are going to be taken to surgery, an excellent mapping of fibroids prior to surgical intervention is recommended. Minimally invasive surgery continues to be the approach of choice, it should be left for the open approach in cases in which Laparoscopy is contraindicated or the patient with multiple myomatosis.
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Balen, Adam H., and Susie Jacob. "Female Infertility and Assisted Reproduction." In Oxford Textbook of Endocrinology and Diabetes 3e, edited by John A. H. Wass, Wiebke Arlt, and Robert K. Semple, 1359–75. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198870197.003.0164.
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Infertility is common. Female age remains the single most important factor determining the ability to conceive. General investigations address all aspects of fertility including tubal assessment, ovarian reserve, and semen analysis. Assisted conception techniques with gamete preparation enhances fertility by either bypassing absolute obstruction or boosting fecundity above that expected without treatment. Limitation of the serious complication of ovarian hyperstimulation syndrome must occur. Cryopreservation has provided a credible option for those wishing to preserve or delay fertility, with success rates equivocal with fresh treatment options. Pre-implantation genetic testing and surrogacy further widen treatment options for previously untreatable conditions. This chapters provides a brief synopsis of fertility investigation and outlines one of the main treatment options, in vitro fertilization.
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Liu, Ji, Yan-Hua Zhou, Xiao-Xiao Wang, Ling-Xi Tong, Yan-Hong Li, Ling Liu, Zhi-Yan Xu, and Hong-Hui Wang. "Effects of Different Types of Incubators on Embryo Development and Clinical Outcomes." In Infertility and Assisted Reproduction [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97833.
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Main differences of incubators are humidity, temperature and gas control ways, which play important roles in regulating the steady state of culture media. In this study, we compared the effects of different types of incubators (air jacket incubators and water jacket incubators) on embryo development and clinical outcomes in human assisted reproduction. We found that temperature recovery time in air jacket incubators was significantly shorter than that in water jacket incubators. Although the O2 recovering time was also significantly shorter in air jacket incubators as compared with the water jacket incubator, no significant differences were observed in CO2 recovering time between two groups, which was also verified by pH recovering time of culture media. Besides, the temperature of culture medium in the dish covered with oil recovered more quickly in the air jacket incubators. However, there were no significant differences observed in the fertilization rate, Day 3 high-quality embryo rate, blastocyst rate, good blastocyst rate and clinical outcomes between two groups. These results indicate that the microenvironment, especially the temperature, in air jacket incubator recover faster than that in water jacket incubators, however, there were no significant differences in embryo development and clinical outcomes between two types of incubators.
Conference papers on the topic "Rats Infertility"
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Mansour, Ayman M., and Mohammad A. Obeidat. "ÓImpact of Infertility Factors on IVF Success Rate using Fuzzy Inference System." In 2021 International Conference on Information Technology (ICIT). IEEE, 2021. http://dx.doi.org/10.1109/icit52682.2021.9491666.
Full textReports on the topic "Rats Infertility"
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Webair, Hana Hasan, Tengku Alina Tengku Ismail, and Shaiful Bahari Ismail. Health seeking behaviour among patients suffering from infertility in the Arab countries; a scoping review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0034.
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Review question / Objective: To identify how much and what is already known about health-seeking behavior (HSB) among the Arab patients who experienced infertility. Our purpose is to map and describe the studies that have been done and what they assessed concerning HSB among patients who experienced infertility. This includes the studies which address the factors affecting HSB. This review is conducted to display gaps in HSB literature and to inform a systematic review in the Arab countries. Condition being studied: The review will study research articles which addressed the HSB among couples, men, or women suffering from infertility. We adopted the definition of HSB by Ward et al. (1997) which is the actions undertaken by the patients who perceive themselves as infertile for the purpose to conceive and get children (Ward, Mertens, & Thomas, 1997). This could be any action ranged from neglect to seeking advanced infertility care. We will study the operational definition of HSB in each study, HSB model, rate of seeking medical care and type of care sought, other sources of help sought, and factors influencing HSB. In addition, we will describe how HSB was studied by defining the characteristics of the retrieved studies including design, setting, participants, and sample size, and infertility operational definition.
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peng, jing, xinyi guo, zhangyin sun, and tongsheng su. Effect of acupuncture on ovulation rate and pregnancy outcome in ovulatory disorders of infertility: a systematic evaluation and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0083.
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