Academic literature on the topic 'Rats; Human'

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Journal articles on the topic "Rats; Human"

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Olsen, Jørn. "Although Some Humans are Rats, not all Rats are Human." European Journal of Epidemiology 20, no. 10 (October 2005): 815. http://dx.doi.org/10.1007/s10654-005-3377-5.

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Holland, Norman N. "Tickled Rats and Human Laughter." Neuropsychoanalysis 9, no. 1 (January 2007): 41–57. http://dx.doi.org/10.1080/15294145.2007.10773541.

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Garau i Florit, Adriana. "Human Extraversion and Ambulation in Rats." Quaderns de Psicologia, no. 15 (October 17, 2009): 23. http://dx.doi.org/10.5565/rev/qpsicologia.538.

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Flynn, PD, RM Lawn, JJ Mullins, and PL Weissberg. "Transgenic Rats Expressing Human Apolipoprotein(a)." Clinical Science 94, s38 (February 1, 1998): 7P. http://dx.doi.org/10.1042/cs094007pa.

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Wildner, Gerhild. "Are rats more human than mice?" Immunobiology 224, no. 1 (January 2019): 172–76. http://dx.doi.org/10.1016/j.imbio.2018.09.002.

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Bohlender, Jürgen, Joël Ménard, Jürgen Wagner, Friedrich C. Luft, and Detlev Ganten. "Human Renin-Dependent Hypertension in Rats Transgenic for Human Angiotensinogen." Hypertension 27, no. 3 (March 1996): 535–40. http://dx.doi.org/10.1161/01.hyp.27.3.535.

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Müller, Dominik N., Karl F. Hilgers, Salima Mathews, Volker Breu, Walter Fischli, Regina Uhlmann, and Friedrich C. Luft. "Effects of Human Prorenin in Rats Transgenic for Human Angiotensinogen." Hypertension 33, no. 1 (January 1999): 312–17. http://dx.doi.org/10.1161/01.hyp.33.1.312.

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Yang, Xiao-Xia, Zen-Ping Hu, Eli Chan, Wei Duan, and Shufeng Zhou. "Pharmacokinetics of Recombinant Human Endostatin in Rats." Current Drug Metabolism 7, no. 6 (August 1, 2006): 565–76. http://dx.doi.org/10.2174/138920006778017803.

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Coghlan, Andy. "Human brain stem cells transplanted into rats." New Scientist 208, no. 2790 (December 2010): 14. http://dx.doi.org/10.1016/s0262-4079(10)63030-8.

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Bohlender, Jürgen, Akiyoshi Fukamizu, Andrea Lippoldt, Tatsuji Nomura, Rainer Dietz, Joel Ménard, Kazuo Murakami, Friedrich C. Luft, and Detlev Ganten. "High Human Renin Hypertension in Transgenic Rats." Hypertension 29, no. 1 (January 1997): 428–34. http://dx.doi.org/10.1161/01.hyp.29.1.428.

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Dissertations / Theses on the topic "Rats; Human"

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Todd, Dorothy A. "A study of pyretics in rats and mice." Thesis, University of Aberdeen, 1986. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU004772.

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In this study, the suitability of rodents for the detection and assay of microbial pyrogens was investigated and the pathophysiology of the 'yeast rat' model, currently used for screening antipyretic drugs, was documented. Mice do not consistently develop pyrexia following systemic injections of bacterial endotoxin (BE). These findings are in contrast to the dose-dependent hyperthermia observed in mice following intrahypothalamic injections of prostaglandin E2 (PGE2), a putative central mediator of pyrexia. Hyperthermia was associated with a decrease in skin temperature or an increase in oxygen consumption depending on the ambient temperature. These results suggest that mice have the ability to co-ordinate thermoregulatory mechanisms to raise their body temperature. Unlike PGE2, BE injected into the preoptic and anterior hypothalamic nuclei did not consistently raise body temperature in mice. This suggests that the failure of systemically administered endotoxin to consistently induce pyrexia is not due to insufficient quantities of pyrogen reaching the central thermoregulatory centres. However, central injections of BE may not mimic the central events occurring during the development of pyrexia as a result of peripheral infection. The inconsistent effect of systemic endotoxin on body temperature in mice in this study suggests that this species is unsuitable for the assay of microbial pyrogens. Unlike mice, rats developed pyrexia following systemic injections of BE; the doses of BE required were at least 100 fold greater than those reported for the rabbit (see General Introduction), rendering rats less sensitive than other species as models for the detection and assay of microbial pyrogens. Yeast also raised body temperature in rats. Pyrexia coincided with the acute phase of a yeast-induced inflammatory response. An abscess was formed at the site of injection; this subsequently developed into a chronic granuloma. The pyrogenic response to yeast was not directly attributable to inflammatory mediators associated with increased vascular permeability, phagocytosis or granuloma formation. It is unlikely therefore, that antipyretic activity displayed by drugs tested in the 'yeast rat' model is due to peripheral anti-inflammatory activity. However, results from this study suggest that BE may be a suitable replacement for yeast as a pyrexic challenge in rats for screening antipyretics. BE would be less emotive than yeast and would not induce a chronic granuloma. No endogenous pyrogenic mediators were detected in yeast-treated rats. No endogenous pyrogen (EP) was obtained from rat blood or peritoneal exudates in vitro. Either rats do not release detectable EP or attempts in this study to activate rat white blood cells in vitro do not mimic events occurring in vivo. Athymic rats injected with yeast developed pyrexia which suggests that Interleukin 1 is not an endogenous pyrogenic mediator unless its release is independent of T-cell derived lymphokines. Changes in thermoregulatory behaviour following pyrogen administration in rats were studied as an alternative method for assaying pyrogens. Detectable changes in thermoregulatory behaviour can precede but do not always accompany changes in body temperature in rats. Therefore, body temperature was considered to be a more reliable measure of thermoregulatory changes than behaviour in this study.
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Mabandla, Musa Vuyisile. "Exercise induced neuroprotection in spontaneuosly running rats." Doctoral thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/3263.

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We investigated the effects of voluntary exercise on neuroprotection after unilateral lesions with 6-hydroxydopamine. Rats were divided into runners (had access to running wheel) and non-runners (their running wheels were immobilised). Two weeks after injection of the neurotoxin, the rats were injected with apomorphine and the number of ipsilateral and contralateral rotations was counted with contralateral rotations of greater than 150 considered to represent striatal dopamine neuron destruction of 70% or above.
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Katō, Norihiro. "Finding genes that cause essential hypertension." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337601.

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Kruszynska, Y. T. "Metabolic effects of portal and peripheral insulin delivery in streptozotocin diabetic rats." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356789.

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Rupanagudi, S. R. "Pathogenesis of thyroid enlargement and involution in rats treated with antithyroid compounds." Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383301.

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Conliffe, Phyllis R. (Phyllis Rowena). "Effects of maternal diabetes on fetal development in rats." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39344.

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The mechanisms underlying the high incidence of fetal abnormalities including fetal lung immaturity during maternal diabetes are not fully understood. Utilizing streptozotocin-diabetic rats as the model, I have examined the role of fetal hyperglycemia and hyperinsulinemia and other factors on fetal adrenal and lung functions in culture. Insulin and glucose did not alter fetal adrenal and lung cell proliferation and adrenal corticosterone output. On the other hand, a novel protein-bound, low molecular weight non-proteinaceous cytotoxic factor was detected in the serum of diabetic animals. In addition, a novel protein with cytostatic activity was found in fetal lungs, the concentration of which increased during diabetes. Partial amino acid sequence and Western Blot analysis revealed this protein to be similar to histone H2B. An extra-nuclear role is suggested for this protein because it appears to be present in the microsomal fraction of fetal lungs. It is concluded that fetal lung immaturity during diabetes may be contributed by cytotoxic and cytostatic factors contained in the serum and fetal lungs, respectively.
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Wan, J. M.-F. "The effect of E. coli endotoxin on the metabolic responses of Wistar rats." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376188.

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Carter, Katharine Christine. "The specificity of the host's immunological response to invasive nematode parasites of rats." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/13330.

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Hulme-Beaman, Ardern. "Exploring the human-mediated dispersal of commensal small mammals using dental morphology : Rattus exulans and Rattus rattus." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=215116.

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A handful of rat species are among the most pervasive mammal species across the globe, primarily because of their close relationship with humans. The processes involved in this relationship, commensalism, are described in detail. Two rat species, Rattus rattus and Rattus exulans, are the focus of this thesis and their biology and taxonomy are described and discussed. Their modern distributions are the direct result of some of the earliest and most extensive human migration events in human history. The archaeology of the Pacific and Indian Oceans is described and migration vectors and spheres of interaction are identified. These possible patterns of human migration and exchange networks provide testable hypotheses that can be investigated using the subject rat species as proxies for long distance human movement. Modern and archaeological tooth samples of R. exulans and modern samples of R. rattus are analysed using geometric morphometrics. The results reveal important aspects of human migration and differences between these species' biology. R. exulans was likely to have been transported out of Island Southeast Asia at a very early date. Human colonisation of the Pacific occurred in a series of complex pulses and pauses that are clearly reflected in the R. exulans data. For the first time it is possible to demonstrate, within one dataset, the multiple origins and directions of colonisation across the Pacific. The R. rattus data provides a striking comparison, showing very different results that allude to a different level of modern gene-­‐ flow and therefore a difference in behaviour and biology. The results provide a framework for comparison with future archaeological material. The results presented and hypotheses raised have immediate application to existing archaeological material and areas of interest. Further commensal species should be examined following similar lines of questioning as applied here.
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El-Shannawy, I. E. S. "Post-mortem changes in in-situ parenchyma cells in rats and humans." Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355699.

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Books on the topic "Rats; Human"

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Eric, Flint, ed. Rats, bats & vats. Riverdale, N.Y: Baen Books, 2000.

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Marrin, Albert. Oh, rats!: The story of rats and people. New York, N.Y: Dutton Childrens Books, 2006.

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Marrin, Albert. Oh, rats!: The story of rats and people. New York, N.Y: Dutton Children's Books, 2006.

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Oh, rats!: The story of rats and people. New York: Dutton Children's Books, 2005.

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Flint, Eric. The rats, the bats & the ugly. Riverdale, N.Y., USA: Baen Books, 2004.

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(Illustrator), Paul Casale, ed. Fourth Grade Rats. New York, NY: Scholastic Inc., 1991.

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Fourth Grade Rats. New York, NY: Scholastic Inc., 1993.

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Miller, Chinle. Desert rats: Adventures in the American outback. [Moab, UT]: Yellow Cat Pub., 2009.

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Rat: How the world's most notorious rodent clawed its way to the top. Toronto: Key Porter Books, 2006.

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Langton, Jerry. Rat: How the world's most notorious rodent clawed its way to the top. Toronto: Key Porter Books, 2006.

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Book chapters on the topic "Rats; Human"

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Tellides, G., N. C. Kirkiles, D. A. Tereb, J. S. Schechner, J. H. Wilson, M. I. Lorber, and J. S. Pober. "Transplantation Models in Human/Mouse Chimeras." In Organtransplantation in Rats and Mice, 615–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72140-3_63.

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Rasheed, S. "Retroviruses and Oncogenes in Rats." In International Symposium: Retroviruses and Human Pathology, 153–75. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-5008-1_14.

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Ganten, D., and J. Wagner. "The Human Renin-Angiotensin-System in Transgenic Rats." In Patenting of Human Genes and Living Organisms, 185–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-85153-7_17.

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Brewer, Lauren M. "Student Subjects: Human Lab Rats or Genuine Consumers?" In Looking Forward, Looking Back: Drawing on the Past to Shape the Future of Marketing, 713. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-24184-5_173.

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Cam, Ertugrul, Ertugrul Kilic, Burak Yulug, and Marie-Françoise Ritz. "Occlusion of the Middle Cerebral Artery in Rats." In New Animal Models of Human Neurological Diseases, 52–65. Basel: KARGER, 2008. http://dx.doi.org/10.1159/000117723.

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Bennink, Maurice R. "Dietary Soy Reduces Colon Carcinogenesis in Human and Rats." In Nutrition and Cancer Prevention, 11–17. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4615-1283-7_2.

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Ciccocioppo, Roberto. "Genetically Selected Alcohol Preferring Rats to Model Human Alcoholism." In Behavioral Neurobiology of Alcohol Addiction, 251–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28720-6_199.

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Yu, Y., Jin Biao Chen, J. L. Yang, D. A. F. Morgan, and W. R. Walsh. "Evaluation of Gamma Irradiated Human Bone in Nude Rats." In Advanced Biomaterials VI, 269–72. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.269.

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Müller-Hermelink, H. K., R. Schoel, and F. Strahlendorf. "Immunohistological Analysis of Late Cellular Rejection and Cyclosporin-A-Resistant Acute Rejection in Human Kidney Allograft: Evidence of Delayed-Type Hypersensitivity Reaction Mechanisms." In Microsurgical Models in Rats for Transplantation Research, 315–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-61657-0_54.

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Sprick, Daniel. "‘Killing Rats in the Street’ for the Paramount Human Right of Security: The Law and Policy of China’s People’s War on Terror." In Human Dignity and Human Security in Times of Terrorism, 181–205. The Hague: T.M.C. Asser Press, 2019. http://dx.doi.org/10.1007/978-94-6265-355-9_9.

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Conference papers on the topic "Rats; Human"

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Yan, Ji-Geng, David J. Rowe, Lin Ling Zhang, Kirkwood A. Pritchard, and Danny Riley. "Apoliprotein Mimetic D-4F Precodition Effects to Prevent Vibration Injury -- Experiment in Rats." In American Conference on Human Vibration 2010. Iowa City, IA: University of Iowa, 2010. http://dx.doi.org/10.17077/achv2010.1005.

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Sarabia-Estrada, Rachel, Alejandro Ruiz-Valls, Courtney R. Goodwin, Sagar Sha, Alfredo Quiñones-Hinojosa, Ziya L. Gokaslan, and Daniel M. Sciubba. "Abstract 5149: An orthotopic model of human chordoma in rats." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5149.

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Hayati, Hamideh, and Yu Feng. "A Precise Scale-Up Method to Predict Particle Delivered Dose in a Human Respiratory System Using Rat Deposition Data: An In Silico Study." In 2020 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/dmd2020-9060.

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Abstract As surrogates to human beings, rats are used occasionally to study the therapeutic impact of inhaled pulmonary drug particles in microscale. To speculate human responses from rat studies, scale-up factors are widely used to extrapolate particle lung deposition from rat to human. However, available scale-up methods are highly simplified and not accurate, because they directly use the human-to-rat ratios of body weights (RBW) or lung surface areas (RSA) as the scale-up factor. To find a precise scale-up strategy, an experimentally validated Computational Fluid-Particle Dynamics (CFPD) was employed to simulate the transport and deposition of microparticles in both human and rate respiratory systems, which encompasses the pulmonary routes from mouth/nose to airways up to Generation 17 (G17) for human and G23 for the rat. Microparticles with the same range of Stk/Fr were injected into both models with the airflow at resting conditions. Numerical results indicate that particles (with the size ranging from 1 to 13 μm for humans and 0.6 to 6 μm for rat) have similar deposition pattern (DP) and deposition fraction (DF) in both models, which are resulted from both inertial impaction and gravitational sedimentation effects. A novel correlation is proposed to predict DFs in both human and rat respiratory systems as a function of the ratio of Stokes number to Froude number (Stk/Fr). Using the correlation as the novel scale-up tool, inter-species extrapolations can be precisely done on predicting particle depositions in human respiratory systems based on the deposition data in rats obtained from animal studies.
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Chunfang, Zhao, Liu Jinping, Cui Xiuyue, Liu Xin, and Li Pingya. "Pharmacokinetics of pseudo-ginsenoside GQ after intravenous administration in rats." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027946.

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Chen, Xi, and Fan Li. "Effects of Arthrigia on adjuvant arthritis rats' serum TNF-α." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027993.

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Ying, Li, Xu Lihua, Zhan Ping, Sun Miying, Zhai Yujia, Xu Lei, and Liu Tongku. "Nerve Growth Factor pretreatment promotes vasculogenesis in rats after myocardial infarction." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6028039.

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Lu-jia, Zhu, and Zhang Li-jing. "Effect of resveratrol on oxidative stress in kidneys of diabetic rats." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6028040.

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Xu, Hong, Fang Yang, Yuan Yuan, Ying Sun, Zhongqiu Wei, Hua Cheng, Shuyu Li, Tan Cheng, and Ruimin Wang. "The role of AcSDKP on inhibiting myofibroblast differentiation in rats with silicosis." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6027958.

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Yanxia, Jiang, Xu Junjie, Lu Xiaojing, Shen Nan, and Lv Shijie. "Change of overoxidation environment and cytokine of high power microwave radiation rats." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6028402.

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Hong, Fen-fang, Xin Wang, Gui-lin Tu, and Shu-long Yang. "Underlying mechanism of effect of Shenfu injection on buerger's disease model rats." In 2011 International Conference on Human Health and Biomedical Engineering (HHBE). IEEE, 2011. http://dx.doi.org/10.1109/hhbe.2011.6029002.

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Reports on the topic "Rats; Human"

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Neel, J. V. Studies of human mutation rates. Office of Scientific and Technical Information (OSTI), July 1991. http://dx.doi.org/10.2172/5025881.

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Neel, J. V. Studies of human mutation rates. Office of Scientific and Technical Information (OSTI), January 1990. http://dx.doi.org/10.2172/6368357.

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Neel, J. V. The study of human mutation rates. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/7175958.

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Thornton-Manning, J. R., J. A. Hotchkiss, and Xinxin Ding. Nasal cytochrome P4502A: Identification in rats and humans. Office of Scientific and Technical Information (OSTI), December 1995. http://dx.doi.org/10.2172/381365.

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Zarulli, Virginia. Mortality shocks and the human rate of aging. Rostock: Max Planck Institute for Demographic Research, April 2012. http://dx.doi.org/10.4054/mpidr-wp-2012-019.

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Thropp, Jennifer E., and Jessie Y. Chen. The Effects of Slow Frame Rates on Human Performance. Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada449963.

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Barbi, Elisabetta. Assessing the rate of ageing of the human population. Rostock: Max Planck Institute for Demographic Research, March 2003. http://dx.doi.org/10.4054/mpidr-wp-2003-008.

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Neel, J. V. The study of human mutation rates. Progress report, 1989--1992. Office of Scientific and Technical Information (OSTI), December 1992. http://dx.doi.org/10.2172/10188260.

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Pavlin, Julie A. Characterization of the Fusion and Attachment Glycoproteins of Human Metapneumovirus and Human Serosurvey to Determine Reinfection Rates. Fort Belvoir, VA: Defense Technical Information Center, May 2007. http://dx.doi.org/10.21236/ad1014038.

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Nandi, Satyabrata. A Rat Model for Human Ductal Carcinoma In Situ. Fort Belvoir, VA: Defense Technical Information Center, September 2005. http://dx.doi.org/10.21236/ada484719.

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