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1
Yin, Rong, Yong Liu, and Dan Meng. "Distributed Randomized Sketching Kernel Learning." Proceedings of the AAAI Conference on Artificial Intelligence 36, no. 8 (June 28, 2022): 8883–91. http://dx.doi.org/10.1609/aaai.v36i8.20870.
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We investigate the statistical and computational requirements for distributed kernel ridge regression with randomized sketching (DKRR-RS) and successfully achieve the optimal learning rates with only a fraction of computations. More precisely, the proposed DKRR-RS combines sparse randomized sketching, divide-and-conquer and KRR to scale up kernel methods and successfully derives the same learning rate as the exact KRR with greatly reducing computational costs in expectation, at the basic setting, which outperforms previous state of the art solutions. Then, for the sake of the gap between theory and experiments, we derive the optimal learning rate in probability for DKRR-RS to reflect its generalization performance. Finally, to further improve the learning performance, we construct an efficient communication strategy for DKRR-RS and demonstrate the power of communications via theoretical assessment. An extensive experiment validates the effectiveness of DKRR-RS and the communication strategy on real datasets.
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Duan, Zhengxiang, Xin Yang, Tao Zhang, and Ling Wang. "Optimal Position and Target Rate for Covert Communication in UAV-Assisted Uplink RSMA Systems." Drones 7, no. 4 (March 28, 2023): 237. http://dx.doi.org/10.3390/drones7040237.
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With the explosive increase in demand for wireless communication, the issue of wireless communication security has also become a growing concern. In this paper, we investigate a novel covert communication for unmanned aerial vehicle (UAV)-assisted uplink rate-splitting multiple access (RSMA) systems, where a UAV adopts the rate-splitting (RS) strategy to increase the total transmission rate while avoiding deteriorating the covert transmission of a ground user. In the proposed system, a ground user and a UAV adopt the RSMA scheme to simultaneously communicate with a base station surveilled by an evil monitor. The UAV acts as both the transmitter and the friendly jammer to cover the ground user’s transmission with random power. To maximize the expected sum rate (ESR), we first study the RS strategy and obtain the optimal power allocation factor. Then, the closed-form of minimum detection error probability (DEP), ESR, and optimal target rate of the UAV are derived. Constrained by the minimum DEP and expected covert rate (ECR), we maximize the ESR by optimizing the position and target rate of the UAV. Numerical results show that the proposed scheme outperforms the traditional NOMA systems in terms of ESR with the same DEP and ECR.
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Tsutsumi, Yusuke, Yasushi Tsujimoto, Sei Takahashi, Asuka Tsuchiya, Shingo Fukuma, Yosuke Yamamoto, and Shunichi Fukuhara. "Accuracy of aortic dissection detection risk score alone or with D-dimer: A systematic review and meta-analysis." European Heart Journal: Acute Cardiovascular Care 9, no. 3_suppl (January 23, 2020): S32—S39. http://dx.doi.org/10.1177/2048872620901831.
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Background: To evaluate the diagnostic accuracy and clinical utility of the acute aortic dissection detection risk score (ADD-RS) alone or with D-dimer as a screening test to exclude acute aortic syndrome. Methods: We conducted a systematic review and meta-analysis of studies examining the diagnostic accuracy of ADD-RS. We searched MEDLINE, Embase and Cochrane Controlled Register of Trials up to 12 December 2018. Results: We identified nine studies involving 26,598 patients for ADD-RS alone and 3421 patients with D-dimer. Overall, the methodological quality based on the Quality Assessment of Diagnostic Accuracy Studies 2 was moderate to high. Bivariate meta-analyses showed that the pooled sensitivities were 0.94 (95% confidence interval (CI) 0.90, 0.96) at the threshold of ADD-RS ≥1, 0.46 (95% CI, 0.34, 0.59) at ADD-RS ≥2, 1.00 (95% CI 0.99, 1.00) at ADD-RS ≥1 with D-dimer and 0.99 (95% CI 0.97, 1.00) at ADD-RS ≥2 with D-dimer. For the low prevalence population, failure rate and efficiency were 0.8% and 38.3% at ADD-RS ≥1, 0.03% and 14.5% at ADD-RS ≥1 with D-dimer, and 0.1% and 33.6% at ADD-RS ≥2 with D-dimer, respectively. For the high prevalence population, failure rate and efficiency were 3.8% and 33.3% at ADD-RS ≥1, 0.2% and 12.3% at ADD-RS ≥1 with D-dimer and 0.6% and 28.4% at ADD-RS ≥2 with D-dimer, respectively. Conclusions: ADD-RS alone or with D-dimer was a useful screening test with high sensitivity to exclude acute aortic syndrome. However, the optimal threshold of ADD-RS alone or with D-dimer may depend on the clinical setting.
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Salman, Ahmed Hasan, Basman Monther Al-Nedawe, and Mohamed Ibrahim Shuja'a. "Improving the error performance of offset pulse position modulation using Reed–Solomon error correction code and low-density parity." International Journal of Electrical and Computer Engineering (IJECE) 13, no. 3 (June 1, 2023): 2847. http://dx.doi.org/10.11591/ijece.v13i3.pp2847-2856.
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An innovative performance study of an offset pulse-position modulation (OPPM) scheme is presented in this work with Reed–Solomon (RS) and low-density parity-checking (LDPC). The main aim is to resolve the errors of OPPM three using an RS or LDPC as a sporadic set of forward error correction (FEC). In this regard, the separate FEC has been utilized with coding that is based on multi-level, and waveform shaping based on the trellis. To systematically conduct this research, the greatest transmission efficiency that associated with the optimum RS code rates at different fiber normalization bandwidths is evaluated. Furthermore, the transmission efficiencies, channel extension, as well as the required number of photons per pulse of OPPM before and after the integration with RS or LDPC are compared. The results indicate an enhancement of mitigating the system's bit error rate and delivering more error-free data to the receiver in the occasion of applying the optimal settings of the RS or LDPC.
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Hussein, Yasmeen M., Basman M. Al-Nedawe, Ammar Hussein Mutlag, and Ameer K. Jawad. "Application of Error Correction Codes RS and LDPC to Enhance the Dicode Pulse Position Modulation." Journal of Hunan University Natural Sciences 49, no. 1 (January 28, 2022): 161–69. http://dx.doi.org/10.55463/issn.1674-2974.49.1.21.
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Dicode Pulse Position Modulation (DiPPM) has been presented as a new coding technique with several improvements over earlier PPM formats. Few analyses and experimental results have been published because it is a new coding scheme. To overcome the problem of bandwidth utilization in current PPM formats, DiPPM can be employed. The line rate is twice as fast as the original data rate. In order to increase DiPPM's error performance, two types of Forward Error Correction (FEC) codes, Reed-Solomon (RS) code and low-density parity-check (LDPC) code, are investigated in this article. When RS and LDPC function at their optimal parameters, the results show an improvement in DiPPM system error performance. The error performance of an uncoded DiPPM system was compared to that of a DiPPM-encoded LDPC system and a system utilizing the Reed-Solomon algorithm. Transmission efficiency is measured by the number of photons per pulse and bandwidth widening. When the bandwidth is 1x103 times or more than the initial data rate, DiPPM with LDPC code exceeds uncoded DiPPM and DiPPM with RS, using 1.821 x 103 photons per pulse, with a codeword length of 27 and code rate of 0.75.
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Wang, Qingren, Guodong Liu, Kelly Morgan, and Yuncong Li. "Implementing the Four Rs (4Rs) in Nutrient Stewardship for Tomato Production." EDIS 2016, no. 1 (February 16, 2016): 6. http://dx.doi.org/10.32473/edis-hs1269-2015.
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Fertilization plays a critical role in tomato production across the state of Florida. However, appropriate fertilization management depends on four major components (4Rs): right source, right rate, right placement, and right timing. Farming practices that follow the 4Rs can provide nutrients for optimal tomato productivity while minimizing the risk of nutrient losses and adverse environmental effects, both of which are important to the development of agricultural sustainability. This 6-page fact sheet discusses the 4Rs as well as conventional dry source fertilizers, controlled-release or slow-release source fertilizers, and liquid source fertilizers. Written by Qingren Wang, Guodong Liu, Kelly Morgan, and Yuncong Li, and published by the UF Department of Horticultural Sciences, October 2015. HS1269/HS1269: Implementing the Four Rs (4Rs) in Nutrient Stewardship for Tomato Production (ufl.edu)
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Wang, Fenglei, Shaochun Ma, Haonan Xing, Jing Bai, Jinzhi Ma, Yezhen Yang, and Jiwei Hu. "Base Cutting Energy Consumption for Sugarcane Stools Using Contra-Rotating Basecutters." Transactions of the ASABE 64, no. 1 (2021): 221–30. http://dx.doi.org/10.13031/trans.13997.
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HighlightsThis study focused on the base cutting energy consumption for sugarcane stools instead of single stalks, thus being more consistent with actual field harvesting.The energy consumption increased with increasing rotational speed (RS) and stool diameter (SD), while it decreased with increasing tilt angle (TA) and feed rate (FR).Each pair of levels of each factor was compared using Duncan’s multiple range test. Three factors (RS, SD, and FR) had significant effects on energy consumption at 95% confidence level, while one factor (TA) had no significant effect.The order of influence and the optimal combination of the four factors to minimize the energy consumed during base cutting were determined.Abstract. Previous studies on contra-rotating basecutter designs based on supported cutting have mainly focused on the base cutting energy consumption for single sugarcane stalks instead of sugarcane stools. However, in the actual base cutting process, a basecutter typically cuts multiple sugarcane stalks (in one sugarcane stool) simultaneously. Therefore, this study investigated how the rotational speed (RS) and tilt angle (TA) of the cutting discs, the sugarcane stool diameter (SD), and the feed rate (FR) affected the energy consumed when cutting cane stools using a contra-rotating cutting platform. Four single-factor experiments and an orthogonal experiment were performed using a Taguchi orthogonal experimental design, and each group was replicated five times. The results of the single-factor experiments showed that the energy consumption was proportional to RS and SD, while it was negatively correlated with TA and FR. The significance of the difference between each pair of levels of each factor was investigated using Duncan’s multiple range test. According to the results of the orthogonal experiment, RS, SD, and FR had significant influences on the base cutting energy consumption at the 95% confidence level; however, TA had no significant influence. The order of influence of the four factors was SD > FR > RS > TA (18.45 > 18.39 > 12.91 > 9.06), and the optimal factor-level combination for minimizing the cutting energy was RS2, TA4, SD1, and FR3 (200 rpm disc RS, 20° disc TA, 60 mm SD, and 1.0 m s-1 FR). An understanding of the relationships between energy consumption and its influencing factors can serve as a valuable reference for researchers seeking to optimize the design of contra-rotating basecutters, which could lead to increased energy efficiency and a reduction in energy consumption during sugarcane harvesting. Keywords: Contra-rotating basecutter, Energy consumption, Orthogonal experiment, Single-factor experiment, Sugarcane stools, Supported cutting.
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Parikh, Sameer A., Neil E. Kay, and Tait D. Shanafelt. "How we treat Richter syndrome." Blood 123, no. 11 (March 13, 2014): 1647–57. http://dx.doi.org/10.1182/blood-2013-11-516229.
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Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RS occurs in approximately 2% to 10% of CLL patients during the course of their disease, with a transformation rate of 0.5% to 1% per year. A combination of germline genetic characteristics, clinical features (eg, advanced Rai stage), biologic (ζ-associated protein-70+, CD38+, CD49d+) and somatic genetic (del17p13.1 or del11q23.1) characteristics of CLL B cells, and certain CLL therapies are associated with higher risk of RS. Recent studies have also identified the crucial role of CDKN2A loss, TP53 disruption, C-MYC activation, and NOTCH1 mutations in the transformation from CLL to RS. An excisional lymph node biopsy is considered the gold standard for diagnosis of RS; a 18F-fluorodeoxyglucose positron emission tomography scan can help inform the optimal site for biopsy. Approximately 80% of DLBCL cases in patients with CLL are clonally related to the underlying CLL, and the median survival for these patients is approximately 1 year. In contrast, the remaining 20% of patients have a clonally unrelated DLBCL and have a prognosis similar to that of de novo DLBCL. For patients with clonally related DLBCL, induction therapy with either an anthracycline- or platinum-based regimen is the standard approach. Postremission stem cell transplantation should be considered for appropriate patients. This article summarizes our approach to the clinical management of CLL patients who develop RS.
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Wang, Fenglei, Shaochun Ma, Wenli Ke, Haonan Xing, and Jing Bai. "Energy Consumption of Sugarcane Basecutting Using Contra- Rotating Basecutters." Transactions of the ASABE 63, no. 2 (2020): 317–24. http://dx.doi.org/10.13031/trans.13415.
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HighlightsThe objective of this study was to investigate the parameters of a new type of contra-rotating basecutter on the energy consumption during support cutting.Rotational speed of basecutting discs and feeding rate of sugarcane stalks had significant influence on the cutting energy consumption, while tilt angle of discs and blade number on each disc had no significant influence on it.The influencing order of the factors used in this research was disc rotational speed > feeding rate > disc tilt angle > blade number, and the basecutting energy was minimum when the above four factors were 150 rpm, 1.0 m·s-1, 20°, and 4.Abstract. Previous studies on a new type of contra-rotating basecutter that was designed based on the support-cutting theory mainly focused on the relationship between the cutting quality of sugarcane stalks and the basecutter parameters. However, the relationship between these factors and the energy consumption during basecutting was not studied. Therefore, a contra-rotating basecutting platform was developed to investigate how the rotational speed (RS) and tilt angle (TA) of the cutting disc, cutting blade number (BN), and sugarcane stalk feeding rate (FR) affected basecutting energy consumption through a series of bench tests, which included four single-factor experiments and a four-factor four-level orthogonal experiment. Results of the single-factor experiments showed that the basecutting energy consumption increased with increasing RS and BN, while the energy consumption decreased with increasing TA and FR. In addition, t-test results among the four levels of each factor indicated that the differences were not significant (p > 0.05) for level 3 vs. 4 of TA, for level 2 vs. 3 and level 2 vs. 4 of BN, and for level 2 vs. 3 of FR. However, there were significant differences between the other two levels of each factor. ANOVA of the orthogonal experiment results showed that RS and FR had significant influence on basecutting energy consumption, while TA and BN had no significant influence. The influencing order of the four factors on energy consumption was RS > FR > TA > BN (F-values of 19.64 > 10.04 > 4.95 > 2.45). Finally, the optimal combination was determined as 150 rpm for RS, 20° for TA, 4 for BN, and 1.0 m.s-1 for FR. This study provides references for the optimal design of contra-rotating basecutters, which could greatly reduce energy consumption during sugarcane harvest. Keywords: Contra-rotating basecutter, Energy consumption, Orthogonal experiment, Single-factor experiment, Support-cutting theory.
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Pan, Lei, Zan Li, Zhengyuan Wang, and Fenggan Zhang. "Joint Relay Selection and Power Allocation for the Physical Layer Security of Two-Way Cooperative Relaying Networks." Wireless Communications and Mobile Computing 2019 (January 1, 2019): 1–7. http://dx.doi.org/10.1155/2019/1839256.
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In this paper, we investigate the physical layer security of cooperative two-way relay transmission systems using the amplify-and-forward (AF) protocol in the presence of an eavesdropper. A joint relay selection (RS) and power allocation (PA) scheme is proposed to protect the source-destination transmission against the eavesdropper. However, due to the high computational complexity, it is difficult to obtain the optimal solution for the system secrecy rate. Fortunately, an approximate optimal solution by using the particle swarm optimization (PSO) algorithm is derived. In the simulations, we use random relay selection with optimal power allocation (RRS-OPA) and equal power allocation with optimal relay selection (EPA-ORS) as benchmark schemes to verify the effectiveness of the proposed method. The simulation results show that the proposed method outperforms both RRS-OPA and EPA-ORS and significantly improves the system performance with low complexity.
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Janilionis, Vytautas V., Žilvinas Bazaras, and Vytautas Janilionis. "COMPARISON OF ROUTING ALGORITHMS FOR STORAGE AND RETRIEVAL MECHANISM IN CYLINDRICAL AS/RS." TRANSPORT 31, no. 1 (January 14, 2014): 11–21. http://dx.doi.org/10.3846/16484142.2014.995130.
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The objective of this research is to propose new routing algorithms for the Storage and Retrieval Mechanism (SRM) in the Cylindrical Automated Storage and Retrieval System (C-AS/RS) and contribute to the system conceptualization by investigating the maximum achievable retrieval request rates for different routing algorithms and system parameters. For this purpose, flexible and detailed simulation model was developed and investigated for 2 SRM types, 3 routing algorithms and a feasible set of system movement and load transfer time parameters. Based on the simulation output, the regression models for different SRM types and routing algorithms were developed for predicting the maximum retrieval request rate. The differences of the average maximum retrieval request rate were evaluated for various system configurations and routing algorithms. The alternative to optimal routing algorithm was proposed, reducing the system performance only by 1.4÷2.4% on average, but requiring significantly less calculations when planning the SRM tour. In addition, the system analysis indicated that SRM vertical velocity and load transfer time have the highest impact on the system performance and for different SRM types the average maximum retrieval request rates differ by 22.2÷31.8%.
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Cao, Bingbing, Tianhui You, Chunyi Liu, and Jian Zhao. "Pricing and Channel Coordination in Online-to-Offline Supply Chain Considering Corporate Environmental Responsibility and Lateral Inventory Transshipment." Mathematics 9, no. 20 (October 18, 2021): 2623. http://dx.doi.org/10.3390/math9202623.
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In this study, we investigate pricing policy and coordination conditions in an online-to-offline supply chain considering corporate environmental responsibility and lateral inventory transshipment. First, we provide demand functions to capture effects of price, corporate environmental responsibility level, and preference degree of the consumer to online channel. Then, we build profit functions and develop three joint pricing and corporate environmental responsibility-level decision models for centralized decision (Scenario CD), retailer Stackelberg game (Scenario RS), and manufacturer Stackelberg game (Scenario MS). Furthermore, we determine the optimal decision policies by solving developed models, and conduct sensitivity analysis of significant factors. Finally, we use a revenue-sharing contract to realize supply chain coordination and find coordination conditions for Scenario RS and MS, and further show the impacts of revenue-sharing rate and investment cost sensitivity on the conditions using numerical studies. We find that optimal joint decision policies can be affected by significant factors to a varying degree. In certain conditions, the revenue-sharing contract can coordinate online-to-offline supply chains considering corporate environmental responsibility and lateral inventory transshipment. Our study proposes a new decision problem, constructs new joint decision models, determines new optimal joint policies, conducts new coordination analysis, and thus contributes to the research on supply chain operations considering corporate environmental responsibility and lateral inventory transshipment.
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Wei, Zhibiao, Hao Ying, Xiaowei Guo, Minghao Zhuang, Zhenling Cui, and Fusuo Zhang. "Substitution of Mineral Fertilizer with Organic Fertilizer in Maize Systems: A Meta-Analysis of Reduced Nitrogen and Carbon Emissions." Agronomy 10, no. 8 (August 6, 2020): 1149. http://dx.doi.org/10.3390/agronomy10081149.
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Organic fertilizer is an effective substitute for mineral fertilizer that improves crop yield and is environmentally friendly. However, the effects of substitution often vary due to complicated interactions among the organic fertilizer substitution rate (Rs), total nutrient supply, and type of cropping system used. We performed a meta-analysis of 133 maize studies, conducted worldwide, to assess maize yield and environmental performance with substitution of mineral fertilizer with organic fertilizer. At an equivalent nitrogen (N) rate, substituting mineral fertilizer with organic fertilizer increased maize yield by 4.22%, reduced NH3 volatilization by 64.8%, reduced N leaching and runoff by 26.9%, and increased CO2 emissions by 26.8%; however, it had no significant effect on N2O or CH4 emissions. Moreover, substitution with organic fertilizer increased the soil organic carbon sequestration rate by 925 kg C ha−1 yr−1 and decreased the global warming potential by 116 kg CO2 eq ha−1 compared with mineral fertilizer treatment. The net global warming potential after organic fertilizer substitution was −3507 kg CO2 eq ha−1, indicating a net carbon sink. Furthermore, the effect of organic fertilizer substitution varied with the fertilization rate, Rs, and treatment duration. Maize yield and nitrogen use efficiency tended to increase with increasing N application rate following substitution of mineral fertilizer with organic fertilizer. Full substitution reduced N losses more than partial substitution. Further analysis revealed that the yield-optimal Rs for organic N in maize production was 40–60%. Moreover, maize yield and nitrogen use efficiency were further increased after long-term (≥ 3 years) combined use of organic and mineral fertilizers. These findings suggest that rational use of organic and mineral fertilizers improves maize productivity, increases soil organic carbon sequestration, and reduces N and C losses.
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AlSaleh, Khalid, Heba Al Zahwahry, Adda Bounedjar, Mohammed Oukkal, Ahmed Saadeddine, Hassen Mahfouf, Kamel Bouzid, et al. "Response to Induction Neoadjuvant Hormonal Therapy Using Upfront 21-Gene Breast Recurrence Score Assay—Results From the SAFIA Phase III Trial." JCO Global Oncology, no. 7 (August 2021): 811–19. http://dx.doi.org/10.1200/go.20.00575.
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PURPOSE Luminal, human epidermal growth factor receptor 2–negative breast cancer represents the most common subtype of breast malignancies. Neoadjuvant strategies of operable breast cancer are mostly based on chemotherapy, whereas it is not completely understood which patients might benefit from neoadjuvant hormone therapy (NAHT). MATERIALS AND METHODS The SAFIA trial is a prospective multicenter, international, double-blind, neoadjuvant phase III trial, using upfront 21-gene Oncotype DX Breast Recurrence Score assay (recurrence score [RS] < 31) to select operable luminal human epidermal growth factor receptor 2–negative patients, for induction hormonal therapy HT (fulvestrant 500 mg with or without goserelin) before randomly assigning responding patients to fulvestrant 500 mg (with or without goserelin) plus either palbociclib (cyclin-dependent kinase 4/6 inhibitor) or placebo. The objectives of this interim analysis were to assess the feasibility of upfront RS determination on core biopsies in the Middle-East and North Africa region and evaluate the efficacy of induction NAHT in patients with an RS < 31. RESULTS At the time of this interim analysis, 258 patients with relative risk were accrued, including 202 patients (RS < 31% to 78.3%) treated with induction NAHT and 182 patients evaluable so far for response. The feasibility of performing the Oncotype DX assays on core biopsy specimens was optimal in 96.4% of cases. Overall, 93.4% of patients showed hormone sensitivity and no difference in NAHT efficacy was noticed between RS 0-10, 11-25, and 26-30. Interestingly, patients with high RS (26-30) showed a trend toward a higher major response rate ( P = .05). CONCLUSION The upfront 21-gene assay performed on biopsies is feasible in our population and has allowed us to select patients with high hormone sensitivity (RS < 31). This approach could be an alternative to upfront surgery without significant risk of progression, particularly during pandemic times.
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Teklu, Misghina G., Corrie H. Schomaker, Thomas H. Been, and Leendert P. G. Molendijk. "A routine test for the relative susceptibility of potato genotypes with resistance to Meloidogyne chitwoodi." Nematology 18, no. 9 (2016): 1079–94. http://dx.doi.org/10.1163/15685411-00003016.
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The population dynamics of Meloidogyne chitwoodi on eight potato genotypes was compared to the susceptible cv. Desiree in four glasshouse experiments. The initial nematode densities consisted of log series 2x, with . Seinhorst’s logistic model was fitted to the final population densities to estimate the parameters maximum multiplication rate (a), maximum population density (M) and the ratios RSa, RSM and . Average RSa and RSM of the seven resistant genotypes were smaller than 0.29%. The ratios on six resistant genotypes and cv. Desiree were the same, 1.3, indicating independence of RS. One genotype stood out with , whereby RSa < RSM. Both RS and were unaffected by pot size or experimental conditions. Screening protocols at second-stage juveniles (g dry soil)−1 in 2 or 3 kg pots were evaluated for distinctiveness between the two genotype groups. Based on the results, an optimal protocol for a routine resistance test is proposed.
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Kim, Min-A., Seung-Geun Yoo, Hyoung-Do Kim, Kyeung-Ho Shin, Young-Hwan You, and Hyoung-Kyu Song. "Group-Connected Impedance Network of RIS-Assisted Rate-Splitting Multiple Access in MU-MIMO Wireless Communication Systems." Sensors 23, no. 8 (April 12, 2023): 3934. http://dx.doi.org/10.3390/s23083934.
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The reconfigurable intelligent surface (RIS) and rate-splitting multiple access (RSMA) are considered as promising technologies for the beyond Fifth-Generation (B5G) and Sixth-Generation (6G) wireless systems by controlling the propagation environment, which attenuates the transmitted signal, and by managing the interference by splitting the user message into common and private messages. Because conventional RIS elements have each impedance connected to the ground, the sum-rate performance improvement of the RIS is limited. Therefore, the new RISs, which have impedance elements connected to each other, have been proposed recently. To be more adaptive to each channel, the optimization of the grouping of the RIS elements is required. Furthermore, since the solution of the optimal rate-splitting (RS) power-splitting ratio is complex, the value should be simply optimized to be more practical in the wireless system. In this paper, the grouping scheme of the RIS elements according to the user scheduling and the solution of the RS power-splitting ratio based on fractional programming (FP) are proposed. The simulation results showed that the proposed RIS-assisted RSMA system achieved a high sum-rate performance compared to the conventional RIS-assisted spatial-division multiple access (SDMA) system. Therefore, the proposed scheme can perform adaptively for the channel and has a flexible interference management. Furthermore, it can be a more suitable technique for B5G and 6G.
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Rokhafrouz, Mohammad, Hooman Latifi, Ali A. Abkar, Tomasz Wojciechowski, Mirosław Czechlowski, Ali Sadeghi Naieni, Yasser Maghsoudi, and Gniewko Niedbała. "Simplified and Hybrid Remote Sensing-Based Delineation of Management Zones for Nitrogen Variable Rate Application in Wheat." Agriculture 11, no. 11 (November 5, 2021): 1104. http://dx.doi.org/10.3390/agriculture11111104.
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Enhancing digital and precision agriculture is currently inevitable to overcome the economic and environmental challenges of the agriculture in the 21st century. The purpose of this study was to generate and compare management zones (MZ) based on the Sentinel-2 satellite data for variable rate application of mineral nitrogen in wheat production, calculated using different remote sensing (RS)-based models under varied soil, yield and crop data availability. Three models were applied, including (1) a modified “RS- and threshold-based clustering”, (2) a “hybrid-based, unsupervised clustering”, in which data from different sources were combined for MZ delineation, and (3) a “RS-based, unsupervised clustering”. Various data processing methods including machine learning were used in the model development. Statistical tests such as the Paired Sample T-test, Kruskal–Wallis H-test and Wilcoxon signed-rank test were applied to evaluate the final delineated MZ maps. Additionally, a procedure for improving models based on information about phenological phases and the occurrence of agricultural drought was implemented. The results showed that information on agronomy and climate enables improving and optimizing MZ delineation. The integration of prior knowledge on new climate conditions (drought) in image selection was tested for effective use of the models. Lack of this information led to the infeasibility of obtaining optimal results. Models that solely rely on remote sensing information are comparatively less expensive than hybrid models. Additionally, remote sensing-based models enable delineating MZ for fertilizer recommendations that are temporally closer to fertilization times.
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Zhou, Yu-Wen, Jia-Ling Wang, Qing-Fang Li, Yuan-Lin He, Lin-Juan Li, Rui-Zhi Liu, Ye Chen, Shuang Zhang, Meng Qiu, and Ji-Yan Liu. "Efficacy and safety of raltitrexed plus S-1 versus regorafenib in patients with refractory metastatic colorectal cancer: a real-world propensity score matching study." Therapeutic Advances in Gastroenterology 15 (January 2022): 175628482210982. http://dx.doi.org/10.1177/17562848221098246.
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Background: Raltitrexed plus S-1 (RS) and regorafenib both showed considerable efficacy for metastatic colorectal cancer (mCRC) patients. This study aims to compare the effectiveness and safety of two different regimens in patients with refractory mCRC. Methods: This retrospective cohort study included mCRC patients who were treated with RS or regorafenib from February 2017 to June 2021. A propensity score matching (PSM) analysis was conducted to balance the baseline characteristics of all patients. Progression-free survival (PFS), overall survival (OS), tumor response, and safety of two regimens were evaluated. Results: A total of 187 patients were included in our study, with 107 patients in the RS group and 80 patients in the regorafenib group. After PSM, 78 pairs were recognized. Patients treated with RS had a semblable PFS compared to those treated with regorafenib before PSM (4.8 months vs 5.5 months, p = 0.400) and after PSM (4.7 months vs 5.4 months, p = 0.430). Patients in the RS group were associated with a longer OS than those in the regorafenib group (13.4 months vs 10.1 months, p = 0.010). A similar trend of OS was also obtained in the matched cohort (13.3 months vs 10.0 months, p = 0.024). Both objective response rate (12.8% vs 5.1%, p = 0.093) and disease control rate (53.8% vs 46.2%, p = 0.337) in the RS cohort were higher than those in the regorafenib group, without significant differences. Adverse events (AEs) of each group were well tolerated. Conclusion: Patients treated with RS demonstrated a longer OS than those treated with regorafenib and had manageable AEs, which could be recognized as a primary choice for refractory mCRC. Plain Language Summary Efficacy and Safety of Raltitrexed plus S-1 Versus Regorafenib in Patients with Refractory Metastatic Colorectal Cancer: A Real-world Propensity Score Matching Study Both raltitrexed plus S-1 (RS) and regorafenib showed considerable efficacy for metastatic colorectal cancer (mCRC) patients. No study has compared the two regimens yet. Therefore, we compare the efficacy and safety between RS and regorafenib to provide an optimal treatment option. We retrospectively included patients with mCRC who failed at least two standard treatments. All enrolled patients received RS or regorafenib treatments. We conducted a propensity score matching to eliminate differences in the enrolled patients. After the analysis, we found no significant differences in progression-free survival in patients between the two groups. However, patients treated with RS had a longer OS than those treated with regorafenib, whether before matching (13.4 months vs 10.1 months, p = 0.010) or after matching (13.3 months vs 10.0 months, p = 0.024). In addition, the adverse effects caused by cancer-related therapy were tolerable for the patient. Certainly, this is a non-randomized retrospective study with a small sample size, so we conducted a propensity score matching to minimize potential bias. Importantly, this is the first research comparing the two treatments, and we believe that the results of this article could present a primary choice for clinical doctors dealing with patients with standard treatments that failed mCRC.
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Lai, Chao An, Bin Bin Li, and Zhi Xia Zhou. "Research on Non-Linear Dynamics Correcting Mechanism of Complex Products and System." Advanced Materials Research 113-116 (June 2010): 679–84. http://dx.doi.org/10.4028/www.scientific.net/amr.113-116.679.
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The technology composition and system architecture of complex products and system (CoPS) is very sophisticated, and the success rate of CoPS development is low. A system-based model for optimal design of CoPS was presented with system dynamics (SD) as the study framework, and Rough Set (RS) theory was used to analysis the structure of feedback loops in causality graph of CoPS, so as to find non-linear dynamics correcting mechanism of CoPS, which can assist inexperienced users to perform simulation analysis for quality and reliability improvement, alternative design evaluation and modularity assessment, thus helping to enhance robustness of CoPS at the design stage and increase the success rate. This paper showed the practical application with a simulation case at last.
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Malkawi, Ahmad, Nasr Alrabadi, Razan Haddad, Azhar Malkawi, Khaled Khaled, and Airemwen Collins Ovenseri. "Development of Self-Emulsifying Drug Delivery Systems (SEDDSs) Displaying Enhanced Permeation of the Intestinal Mucus Following Sustained Release of Prototype Thiol-Based Mucolytic Agent Load." Molecules 27, no. 14 (July 19, 2022): 4611. http://dx.doi.org/10.3390/molecules27144611.
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In this study, mucoactive self-emulsifying drug delivery systems (SEDDSs) based on sustained release of N-acetylcysteine (NAC) were developed for providing effective intestinal mucopermeation. Polymeric ionic complexes of NAC were formed with polyethyleneimine (PEI), Eudragit E 100, and Eudragit RS 100 and loaded into a novel SEDDS. The SEDDSs exhibited a stable average size of 75 ± 12 nm (polydispersity index (PDI) < 0.3) and showed a rise in the zeta potential from −17.31 mV to −7.72 mV. On Caco-2 cells, SEDDSs at 1–3% were non-cytotoxic. An average of 91.8 ± 5.4% NAC was released from SEDDSs containing Eudragit E 100 (p ≤ 0.05) and Eudragit RS 100 (p ≤ 0.001) complexes at a significantly slower rate within 80 min, whereas the SEDDS containing PEI released NAC in a matter of seconds. Similarly, the SEDDS complexes revealed a time-dependent reduction in mucus dynamic viscosity of 52.6 ± 19.9%. Consequently, as compared with a blank SEDDS, mucodiffusion revealed about 2- and 1.8-fold significantly greater mucopermeation of SEDDSs anchoring Eudragit E 100–NAC and RS 100–NAC complexes (p ≤ 0.05), respectively. The mucoactive SEDDSs, which steadily released NAC while permeating the mucus, were linked to a significantly increased mucopermeation in vitro as a result of optimal mucolytic targeting.
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Romero-Borbón, Evelyn, Andrea Edith Oropeza-González, Yolanda González-García, and Jesús Córdova. "Thermochemical and Enzymatic Saccharification of Water Hyacinth Biomass into Fermentable Sugars." Processes 10, no. 2 (January 24, 2022): 210. http://dx.doi.org/10.3390/pr10020210.
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Water hyacinth (WH) is a free-floating perennial aquatic plant that is considered a pest, due to its rapid grown rate and detrimental effects on environment and human health. It is nearly impossible to control WH growth, with mechanical extraction being the most acceptable control method; nevertheless, it is costly and labor-intensive. WH lignocellulosic biomass represents a desirable feedstock for the sustainable production of liquid fuels and chemical products. In this work, optimal conditions of thermochemical pretreatment for the release of reducing sugars (RS) from WH biomass were established: 0.15 mm of particle size, 50 g of dried solid/L of H2SO4 (3% w/v) and 20 min of heating time at 121 °C. Applying this pretreatment, a conversion of 84.12% of the hemicellulose fraction in the raw WH biomass into reducing sugars (277 ± 1.40 mg RS/g DWH) was reached. The resulting pretreated biomass of WH (PBWH) was enzymatically hydrolyzed by using six enzymatic complexes (all from Novozymes). Among them, NS22118 (beta-glucosidase) and Cellic® CTec2 (cellulase and hemicellulose complex) achieved higher saccharifications. By using NS22118 or a mixture of NS22118 and Cellic® CTec2, PBWH conversion into RS was complete. Monosaccharides released after pretreatment and enzymatic hydrolysis were mostly pentoses (arabinose and xylose) and hexoses (glucose), respectively.
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Bao, Chengli, Tao Zhou, Laixin Shi, Mingao Li, Li Hu, Mingbo Yang, and Qiang Chen. "Hot Deformation Behavior and Constitutive Analysis of As-Extruded Mg–6Zn–5Ca–3Ce Alloy Fabricated by Rapid Solidification." Metals 11, no. 3 (March 14, 2021): 480. http://dx.doi.org/10.3390/met11030480.
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The plasticity of Mg–6Zn–5Ca–3Ce alloy fabricated by rapid solidification (RS) at room temperature is poor due to its hexagonal-close-packed (HCP) structure. Therefore, hot deformation of RS Mg–6Zn–5Ca–3Ce alloy at elevated temperature would be a major benefit for manufacturing products with complex shapes. In the present study, hot deformation behavior of as-extruded Mg–6Zn–5Ca–3Ce alloy fabricated by RS was investigated by an isothermal compression test at a temperature (T) of 573–673 K and strain rate (ε˙) of 0.0001–0.01 s−1. Results indicated that the flow stress increases along with the declining temperature and the rising strain rate. The flow stress behavior was then depicted by the hyperbolic sine constitutive equation where the value of activation energy (Q) was calculated to be 186.3 kJ/mol. This issue is mainly attributed to the existence of fine grain and numerous second phases, such as Mg2Ca and Mg–Zn–Ce phase (T’ phase), acting as barriers to restrict dislocation motion effectively. Furthermore, strain compensation was introduced to incorporate the effect of plastic strain on material constants (α,Q,n,lnA) and the predicted flow stresses under various conditions were roughly consistent with the experimental results. Moreover, the processing maps based on the Murty criterion were constructed and visualized to find out the optimal deformation conditions during hot working. The preferential hot deformation windows were identified as follows: T = 590–640 K, ε˙ = 0.0001–0.0003 s−1 and T = 650–670 K, ε˙ = 0.0003–0.004 s−1 for the studied material.
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Xie, Luxin, Jun Wang, Shaoming Cheng, and Jinbing Hu. "Optimization of a Whole-Stalk Operating System after Sugarcane Base Cutting." Transactions of the ASABE 62, no. 1 (2019): 157–66. http://dx.doi.org/10.13031/trans.12508.
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Abstract. Leaf stripping and top breaking are the key procedures in whole-stalk sugarcane harvesting. In this study, a whole-stalk operating system after sugarcane base cutting was developed and tested to improve the leafy trash cleaning performance and adaptability of a whole-stalk harvester. A leaf shredding procedure was proposed before leaf stripping, and an anti-float top breaking device was developed for breaking cane tops. The rotational speeds of the leaf shredding (RL), leaf stripping (RS), and top breaking (RT) rollers were regarded as experimental factors, and the leafy trash content (including leaves, leaf sheaths, and tops in this study), top breaking rate, abrasion rate, and non-fracture rate of the middle or bottom parts were selected as indices. Central composite design combined with response surface methodology and comprehensive evaluation method were employed to conduct experiments and explore the interaction effects of factors on indices. The optimal operating parameters were nonlinearly optimized and determined to be RL of 512.9 rpm, RS of 418.8 rpm, and RT of 307.0 rpm. Under these conditions, the predicted values of leafy trash content, top breaking rate, abrasion rate, and non-fracture rate were 4.98%, 88.39%, 5.19%, and 96.21%, respectively. Verification experiments indicated that the observed values were in agreement with the predicted values. Results suggested that the leaf shredding device and anti-float top breaking device developed in this study were effective for improving the leafy trash cleaning performance and adaptability of the whole-stalk operating system, and there was a good potential for performance improvement of whole-stalk sugarcane harvesters. Keywords: Central composite design, Leaf shredding, Leaf stripping, Response surface methodology, Top breaking, Whole-stalk harvester.
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Zhao, Ning Bo, Shu Ying Li, Shuang Yi, Yun Peng Cao, and Zhi Tao Wang. "Fault Diagnosis Based on Rough Set and BP Neural Network (RS-BP) for Gas Turbine Engine." Advanced Materials Research 732-733 (August 2013): 397–401. http://dx.doi.org/10.4028/www.scientific.net/amr.732-733.397.
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This paper presents a new fusion diagnosis based on rough set and BP neural network for the fault diagnosis of gas turbine. The frame is designed to fusion fault diagnosis, which is composed by three parts: the rough set data pre-processor, rough set diagnosis model and BP neural network diagnosis model. Aiming at the difficulty in getting adequate fault samples in fault diagnosis, rough set theory is first used to process the original data, establish the decision table and generate rules, which can eliminate the redundant information and build the rough set diagnosis model. After that, according to the optimal decision attribute pre-treated by rough set, BP neural network is designed for fault diagnosis, which can reduce the scale of neural network, improve the identification rate, and improve the efficiency of the whole fusion diagnosis system. Finally, an example of gas turbine generator sets fuel system is taken as a case study to demonstrate the feasibility and validity of the proposed method in this paper.
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Zhang, Hong, Hualong Liu, Yong Zeng, Yurong Tang, Zhaoguo Zhang, and Ji Che. "Design and Performance Evaluation of a Multi-Point Extrusion Walnut Cracking Device." Agriculture 12, no. 9 (September 18, 2022): 1494. http://dx.doi.org/10.3390/agriculture12091494.
Full textAbstract:
The practical problems of existing methods of walnut cracking under compression loading, including incomplete walnut-shell crushing, broken walnut kernels, and so on, are widespread in walnut processing and are constraints that hinder mechanized walnut processing. Therefore, attempts have been made to design and optimize a multi-point extrusion walnut cracking device. For this, walnuts were fed manually into a cracking unit through the hopper. The tangential force of the grading roller graded the walnuts and dropped them into the gap between the rotating cracking roller and extrusion plate, causing them to crack. The developed machine was tested and the parameters were optimized using a central composite design (CCD). The objective functions involving the cracking angle (CA: 0.17, 0.27, 0.52, 0.76, 0.86°) and roller speed (RS: 63, 75, 105, 135, 147 r/min) were calculated. The shell cracking rate (SCR), whole kernel rate (WKR), and specific energy consumption (Es) regression models were established using the quadratic regression orthogonal combination test and the parameters were optimized using MATLAB software. The results showed that the most significant factors for the RS were the linear terms of the SCR and WKR, whereas for the CA the most significant factor was the linear term of the Es. The interaction term of the two factors had a significant effect on the three indicators. The optimal parameter combination was determined to be 0.47° for the CA and 108 r/min for the RS. On this basis, the adaptability test showed that the cracking device had a better cracking effect on walnuts with a gap between the walnut shell and kernel greater than 1.6 mm and a shell thickness less than 1.2 mm. The results have practical significance for the design of walnut cracking devices.
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Michallet, Anne-Sophie, Pierre P. Sesques, Kari G. Rabe, Jeremy Tordot, Christelle Tychyj-Pinel, Baseggio Lucile, Gilles Salles, Jehan Dupuis, and Michael J. Conte. "Tumoral Maximum Standardized Uptake Value > 10 Measured on 18 f-FDG-PET: A New Valid Marker to Discriminate Richter Syndrome." Blood 124, no. 21 (December 6, 2014): 3306. http://dx.doi.org/10.1182/blood.v124.21.3306.3306.
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Abstract Background: One of the main complications in CLL is Richter syndrome (RS). RS derives from the rare transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly of the diffuse large B-cell lymphoma (DLBCL) type. RS occurs in 2.2% to 8% of patients with CLL and the prognostic is poor with a median survival from 5 to 8 months. Detection of RS by imaging has resulted in conflicting and non-significant results. Aim: The objective of this study was to validate recent findings correlating FDG/PET imaging and histological features in CLL and to demonstrate that a tumoral maximum standardized uptake value > 10 measured on 18F-FDG-PET is a new valid marker to discriminate RS. Results: From June 2006 through December 2012, 240 patients from the Division of hematology of Centre Hospitalier Lyon Sud and Créteil and from the Mayo Clinic Rochester have been analyzed with a mean age of 62 years (21-91). Clinical, histological (confirm by biopsy) and biological parameters have been identified with 10% of the patients as having RS, 34% stable CLL disease; 42% of rapid CLL progression (histological features of progression defined as increased large cell number, large confluent proliferation centers or high proliferation rate assessed by Ki-67 but not meeting criteria for diffuse large B-cell lymphoma/RS) and 14% with others diseases (e.g. infection and or cancers). For patients with stable CLL disease, the median tumoral SUV max was 2 (range: 0-2.4). Among patients with a rapid progression of CLL, 90% had a tumoral SUV max <10 but greater than the liver median SUV max (4.5 range: 1-11). In contrast, 90% of patients with RS had a median tumoral SUV max >10 (12.9; range: 5-27). A statistically significant difference between SUV max of CLL patients with stable disease and RS was observed (2.2 vs. 12.9; p< 0.0001) and similarly for SUV max of CLL patients with rapid disease progression and RS (4.5 vs 12.9; p< 0.0001). Regardless of the RS prevalence (2.2% to 8%), statistical tests identified a threshold of tumor SUV max > 10 as the more discriminating cut off. Using this threshold, the sensitivity and specificity of PET to identify RS in our cohort are 91% and 95% respectively. Assuming an RS prevalence of 2.2%, positive predictive value (PPV) and negative predictive value (NPV) using the >10 threshold were 28.7% and 99.8%; for an 8% prevalence of RS, the PPV and NPV are 60.8 and 99.2% respectively.The proportion of correctly classified patients with RS is more accurate using a threshold of tumoral SUV max > 10 than 5 (2.2% RS prevalence: 94.8% versus 71.8%; 8% RS prevalence: 94.6% versus 73.5%). Finally analysis of the area under the curve (AUC) reveals a value of 0.95 (95% confidence interval: 0.89- 0.99). Recently, Falchi et al, reported on 332 patients with CLL classified as 95 RS, 117 rapid progression and 120 stable disease and demonstrated a strong correlation between histological features and PET imaging. A SUV max ≥10 strongly correlated with a shorter overall survival. Similarly, in our study we have shown excellent sensitivity and negative predictive value estimated at 100%, revealing the ability of 18F-FDG-PET-CT to rule out the diagnosis of RS if the tumor SUV max is less than 10. Conclusion: 18F-FDG-PET-CT is a valuable tool in the diagnostic evaluation of RS for patients with CLL. It is not only useful to identify RS syndrome and guide the site of biopsy but also to identify CLL patients who will experience more rapid disease progression. An SUV max > 10 is the optimal threshold to distinguish RS in CLL. Disclosures No relevant conflicts of interest to declare.
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Kozak, K. V., H. A. Pavlyshyn, I. Y. Avramenko, O. M. Dyvonyak, O. O. Shevchuk, and K. T. Hlushko. "SARS-CoV-2 infection and thyroid dysfunction in children." Ukrainian Biochemical Journal 95, no. 3 (July 10, 2023): 12–21. http://dx.doi.org/10.15407/ubj95.03.012.
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The problem of thyroid dysfunction related to SARS-CoV-2 infection remains unclear in children. Therefore, the study aimed to reveal the interrelationship between thyroid dysfunction and COVID-19 severity as well as to determine optimal cut-off values for screening for thyroid disorders in children. A total number of 90 children aged from 1 month to 17 years were involved in the study. Patients with known thyroid disease were not recruited for the research. A thyroid panel was assessed for all participants that included: free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and anti-thyroid peroxidase (ATPO) antibodies. Statistical analysis was done using the computer software Statistica 13.0. Research has revealed euthyroid sick syndrome (ESS) in 14.10% of SARS-CoV-2 infected children more often among patients with severe COVID-19 and multisystem inflammatory syndrome (33.33%) compared to mild COVID-19 course (6.67%) and moderate disease severity (8.89%) (P < 0.05). Significant correlation relationships were revealed for next values – FT3 and erythrocyte sedimentation rate (ESR) (rs = -0.22; P < 0.05); FT3 and C-reactive protein (CRP) (rs = -0.33; P < 0.05); FT3 and procalcitonin (rs = -0.43; P < 0.05). The next cut-off values for ESS determination were revealed: ESR 18.5 mm/h (AUC 0.803); CRP 11.5 mg/l (AUC 0.763); ferritin 84.8 ng/ml (AUC 0.733). Results suggest that pediatricians should pay attention to the endocrine disruptions by COVID-19 in children. Keywords: COVID-19, euthyroid sick syndrome in children, inflammatory markers
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Conceição, Filipe, Marco Gomes, Vitor Silva, Rui Dinis, and Carlos Henggeler Antunes. "Bi-Objective Power Optimization of Radio Stripe Uplink Communications." Electronics 11, no. 6 (March 10, 2022): 876. http://dx.doi.org/10.3390/electronics11060876.
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The radio stripe (RS) system is a practical implementation of cell-free mMIMO, in which a set of multi-antenna access points (APs) serves at the same time-frequency resources the user equipment (UE) in the network. The APs are sequentially connected in a stripe, sharing the same fronthaul link to the central processing unit. This work considers an uplink power optimization problem that aims to enhance the network spectral efficiency (SE) by considering two metrics—the max–min fairness and the max–sum rate. We employ a meta-heuristic based on the differential evolution algorithm to solve the bi-objective optimization problem. The SE performances of the full power along with the single-objective and multiple-objective scenarios are analyzed and compared for the optimal sequential linear processing detection scheme. The bi-objective approach is able to unveil the trade-offs to identify solution balancing the SE distribution resulting from the optimization of the max–min fairness and the max–sum rate objective functions.
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Prodanyk, A. M., O. V. Samborska, O. V. Gorlachova, S. M. Gorbachova, and T. A. Sheliakina. "Application amylos-free starch millet (Panicum miliaceum L.) varieties." Plant Breeding and Seed Production, no. 120 (December 30, 2021): 45–52. http://dx.doi.org/10.30835/2413-7510.2021.251036.
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Materials and methods. Four amylopectin varieties Chabanivske, Zhyvynka (NSC Institute of Agriculture) and Osoblyve and Alternatyvne (Institute of Plant Industry named after V.Ya. Yuriev) were taken as experimental material. The main economically valuable characteristics of the varieties and their biochemical properties of grain were made in 2018–-2020. The main technological indicators of the dough and the assessment of the quality of bread from a mixture of spring wheat flour of the Myronivska variety and grain flour of the Chabanivske variety were carried out in accordance with the current methods. Millet flour was added to wheat flour in proportions of 2.5, 5.0, 7.5 and 10.0%.
The purpose of our research was to study the main economically valuable traits, biochemical properties and resistance to 13 smut races of Ukrainian amylopectin varieties of millet and to determine the optimal percentage of adding millet flour to spring wheat flour to improve the quality of bread.
The discussion of the results. According to the results of scientific work, it has been established that millet waxy varieties differ in their economically valuable characteristics. So, varieties Chabanivske and Zhyvynka have a short growing season, on average, 75 and 77 days, respectively, and varieties Osoblyve and Alternatyvne – 93 and 100 days, respectively. Due to the increased height of the plants of the Osoblyve and Alternatyvne varieties, they can also be grown for animal feed. In terms of biochemical parameters, modern amylopectin varieties did not differ significantly, but showed a high content of protein (13.50–14.0%) and carotenoids (4.8–5.6 mg/kg). Amylos-free starch genotypes varied significantly in terms of head smut resistance. Variety Chabanivske was affected by 13 smut races, varieties Alternatyvne and Osoblyve received 8 and 7 points in 1 and 10 races. Variety Zhyvynka showed high resistance to 8 smut races: Rs 1, Rs 4–Rs 7, Rs 9–Rs 11 – 9 points. The addition of flour from amylos-free starch millet improved the elasticity and extensibility of the dough, increased the balance of these physical properties of the dough with each other, improved the strength of the flour, but did not affect the sedimentation rate. Bread baked with the addition of 2.5% or 5.0% Chabanivske grain flour to the Myronivska spring wheat flour had a larger volume, better taste and appearance compared to the standard.
Conclusions. Waxi varieties (Chabanivske, Zhyvynka, Osoblyve, Alternatyvne), were developed in Ukraine, are characterized by high economically valuable traits and high indicators of grain quality. The main use of these varieties is grain and fodder. The Zhyvynka variety is characterized by high resistance (9 points) to 8 races of smut (Rs 1, Rs 4–Rs 7, Rs 9–Rs 11). The addition of Chabanivske grade waxy-millet flour to wheat flour improves its baking qualities and the taste of bread, while the films are additional fiber that promotes digestion
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Nielsen, Izabela Ewa, Sani Majumder, and Subrata Saha. "Game-Theoretic Analysis to Examine How Government Subsidy Policies Affect a Closed-Loop Supply Chain Decision." Applied Sciences 10, no. 1 (December 23, 2019): 145. http://dx.doi.org/10.3390/app10010145.
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The pros and cons of government subsidy policies in a closed-loop supply chain (CLSC) setting on optimal pricing, investment decisions in improving product quality, and used product collection under social welfare (SW) optimization goal have not been examined comprehensively. This study compares the outcomes of three government policies under manufacturer-Stackelberg (MS) and retailer-Stackelberg (RS), namely (i) direct subsidy to the consumer, (ii) subsidy to the manufacturer to stimulate used product collection, and (iii) subsidy to the manufacturer to improve product quality. Results demonstrate that the greening level, used product collection, and SW are always higher under the RS game, but the rate of a subsidy granted by the government is always higher under the MS game. Profits for the CLSC members and SW are always higher if the government provides a subsidy directly to the consumer, but productivity of investment in the perspective of the manufacturer or government are less. In a second policy, the government organizations grant a subsidy to the manufacturer to stimulate used product collection, but it does not necessarily yield the desired outcome compared to others. In a third policy, the manufacturer receives a subsidy on a research and development (R&D) investment, but it yields a sub-optimal greening level. This study reveals that the outcomes of subsidy policies can bring benefit to consumers and add a degree of complication for CLSC members; government organizations need to inspect carefully among attributes, mainly product type, power of CLSC members, and investment efficiency for the manufacturer, before implementing any subsidy policies so that it can lead to an environmentally and economically viable outcome.
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Saeed, Aneesa, Siti Hafizah Ab Hamid, and Asmiza Abdul Sani. "Cost and Effectiveness of Search-Based Techniques for Model-Based Testing: An Empirical Analysis." International Journal of Software Engineering and Knowledge Engineering 27, no. 04 (May 2017): 601–22. http://dx.doi.org/10.1142/s021819401750022x.
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Model-based testing (MBT) seems to be gaining interest in industry and academia due to its provision of systematic, automated and comprehensive testing. The challenge in MBT is to generate optimal test data to execute test cases. Recently, researchers have successfully applied search-based techniques (SBTs) by automating the search for an optimal set of test data at reasonable cost compared to other more expensive techniques. In real complex systems, effectiveness and cost of SBTs for MBT in industrial context are little known. The objective of this study is to empirically evaluate the cost and the effectiveness of SBTs for MBT on industrial case studies. We applied a model-driven approach and SBTs to automatically generate executable feasible test cases. The results show that the model-driven approach generated high number of infeasible test cases with less time while genetic algorithm (GA) and simulating annealing (SA) outperformed significantly random search (RS) with high generation time. We concluded that local SBTs are more appropriate to generate test data when the type of the constraints is simple. Current work on analyzing the cost and effectiveness on SBTs for MBT indicates possible enhancement using the model-driven approach to detect the infeasible paths and SBTs to achieve optimal success rate.
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Zhang, Guanghe, Weijun Zhao, Tingting Yan, Wei Qin, and Xiaojing Miao. "Estimation of Gully Growth Rate and Erosion Amount Using UAV and Worldview-3 Images in Yimeng Mountain Area, China." Remote Sensing 15, no. 1 (December 31, 2022): 233. http://dx.doi.org/10.3390/rs15010233.
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Non-homogeneous soil’s high gravel content (also known as the “soil-rock dual structure”) may render it more prone to erosion and the significant development of gullies. In order to reveal the morphological characteristics and erosion rate of gullies in “soil-rock dual structure” areas, this study focused on the Shagou Reservoir basin in the Yimeng mountain area as the study area. Based on a complete digital orthophoto map (DOM, 0.03 m) and a digital elevation model (DEM, 0.03 m) acquired by an unmanned aerial vehicle (UAV), the researchers calculated the length (L), top width (TW), depth (D), area (A) and volume (V) of 19 gullies and built and optimized the volume estimation model. The DOM and the DEM were used to modify the morphological parameters of 43 gullies extracted from high-resolution remote sensing (RS) stereopair images (Worldview, 0.5 m), and the development and evolution of gully erosion were evaluated in large scale. The results showed that: (1) after correction, the average relative errors of parameters L, TW, D and A computed from the UAV data and the high-resolution RS stereopair image data fell below 0.005%; (2) the mean of TW/D was 5.20, i.e., the lateral erosion development of gullies far outweighed the downcutting erosion. The retrogressive erosion, lateral erosion and downcutting erosion rates of gullies were 0.01~0.83 m/a (averaged at 0.23 m/a), 0.01~0.68 m/a (averaged at 0.25 m/a) and 0.01~0.19 m/a (averaged at 0.09 m/a), respectively, between 2014 and 2021; (3) the volume-area (V-A) model for gullies is the optimal one (p < 0.01, R2 = 0.944).A total of 90.7% of the gully volume was growing at an erosion rate of 0.42~399.39 m³/a and the total erosion rate of the gullies was 3181.56 m3/a from 2014 to 2021. These research findings can serve as a basis for the quantitative modeling of gully erosion in water-eroded locations with a large-dimension “soil-rock dual structure”.
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Cevik, F., M. Celik, P. M. Clark, and C. Macit. "Sedation and Analgesia in Intensive Care: A Comparison of Fentanyl and Remifentanil." Pain Research and Treatment 2011 (July 2, 2011): 1–9. http://dx.doi.org/10.1155/2011/650320.
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Optimal sedation and analgesia are of key importance in intensive care. The aim of this study was to assess the quality of sedoanalgesia and outcome parameters in regimens containing midazolam and either fentanyl or remifentanil. A prospective, randomized, open-label, controlled trial was carried out in the ICU unit of a large teaching hospital in Istanbul over a 9-month period. Thirty-four patients were randomly allocated to receive either a remifentanil-midazolam regimen (R group, ) or a fentanyl-midazolam regimen (F group, ). A strong correlation between Riker Sedation-Agitation Scale (SAS) and Ramsey Scale (RS) measurements was observed. Comparatively, remifentanil provided significantly more potent and rapid analgesia based on Behavioral-Physiological Scale (BPS) measurements and a statistically nonsignificantly shorter time to discharge. On the other hand, remifentanil also caused a significantly sharper fall in heart rate within the first six hours of treatment.
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Interpares, Prima, Haryadi Haryadi, and Muhammad Nur Cahyanto. "PENGARUH RETROGRADASI PADA PEMBUATAN SOHUN PATI JAGUNG TERHADAP KARAKTERISTIK FISIKOKIMIA PRODUK DAN AKTIVITAS PREBIOTIKNYA (The Effect of Retrogradation on the Physicochemical Properties of Maize Starch Noodle and Its Prebiotic Potential)." Jurnal Agritech 35, no. 02 (September 1, 2015): 192. http://dx.doi.org/10.22146/agritech.9406.
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The study was aimed to determine the optimal storage time of steamed maize starch noodle that gives the desirable properties along with the prebiotic potential. Noodle was prepared by extrusion of the partially cooked maize starch, followed by steaming the strands, and keeping strands at 4 C at various time (0, 1, 2, and 3 h) to enhance retrogradation, and then drying the noodle. The resulted noodle was characterized for physicochemical properties. To evaluate the prebiotic activity, the noodle was rehydrated, and then hydrolyzed by porcine pancreati 30 U/mg) and amyloglucosidase (enzym activity 300 U/mL) to obtain the resistant starch (RS) Type 3. The prebiotic activity of the RS was analayzed by the relative growth ratios of the probiotic bacterias, i. e. ATCC 15707 and JCM 1551, to the enteric bacteria ( IFO 3301) on thefor control.The results showed that the longer storage time of the cooked starch noodle strands led to the higher values of hardness and cooking time, but lower cooking loss and swelling index, indicating the different level of retrogradation. Prebiotic activities of the RS obtained from cooked noodle strands kept for 3 h was 0.730 based on the growth rate of the , and 0.041 based on that of the . The score for the ocommercial RSI, commercial RSII and inulin were 1.058; 0.405; and 1.130 based on the growth of respectively. The prebioctic activities onfor the commercial RSI, commercial RS II and inulin were 0.062; 0.066; and 0.076 respectively.Keywords: Maize starch noodle, retrogradation, product property, prebiotic activity ABSTRAKPenelitian ini bertujuan untuk pati jagung dan mengetahui nilai aktivitas prebiotik produk sebagai hasil pembentukan sifat fungsional prebiotiknya.Penelitian dilakukan dengan perlakuan variasi lama waktu retrogradasi 0, 1, 2 dan 3 jam pada pembuatan sohun terlarut, rehidrasi, rasio pengembangan, elongasi, , tekstur, dan kuat patah sohun kering). Hasil analisis dibandingkan dengan sampel komersial dan dipilih produk yang memiliki karakteristik sama dengan produk komersial. Produk terpilih dipreparasi menjadi RS ((30 U/mg) dan enzim amiloglukosidase (300 U/mL), lalu sampel dicuci dengan alkohol 50%, dikeringkan dandisimpan 4 C hingga pemakaian. Analisis nilai aktivitas prebiotik dilakukan dengan menumbuhkan bakteri probiotik (ATCC 15707JCM 1551) dan bakteri enterik (IFO3301) pada media yang mengandung substrat 1% RS sohun teretrogradasi,1% glukosa, 1% RS produk komersial, 1% inulin dan kontrol selama 24 jam pada 37oC.ATCC 15707 diinkubasi pada kondisi anaerobik sedangkan IFO 3301dan JCM 1551 diinkubasi secara aerobik. Nilai aktivitas prebiotik ditentukan berdasarkan pertumbuhan populasi sel bakteri probiotik dan enterik selama 0 dan 24 jam. Hasil penelitian menunjukkan perlakuan retrogradasi 3 jam pada suhu 4ooC menghasilkan sohun pati jagung dengan mutu yang paling mendekati produk komersial. Pengaruh lama waktu retrogradasi berbeda nyata terhadap kadar air produk akhir, lama pemasakan, totalkehilangan padatan terlarut, rasio pengembangan, dan tekstur. Nilai aktivitas prebiotik sohun pati jagung teretrogradasi3 jam pada pertumbuhan sebesar 0,730 dan 0,041. Nilai aktivitas prebiotik komersial A,komersial B, dan inulin pada adalah 1,058; 0,405 dan 1,130 sedangkan pada nilai aktivitasnya sebesar 0,062; 0,066; dan 0,076.Kata kunci: Sohun pati jagung, retrogradasi, mutu produk, nilai aktivitas prebiotik
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Nhut, Le Minh, and Youn Cheol Park. "A Study on Developing an Automatic Controller with an Inverter Collector Pump for Solar-Assisted Heating System." Energies 13, no. 9 (April 27, 2020): 2128. http://dx.doi.org/10.3390/en13092128.
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In this study, based on the optimal equation m = 0.05 Δ T A c (kg/min) of the variable mass flow rate in the collector loop, an automatic controller with an inverter collector pump for the collector loop of the solar-assisted heating system is designed for these experiments and to then be used for real industry. The pump for the collector loop is an inverter type that is controlled by an embedded controller with Windows, based on C# language, and the change of speed depends on the variation of the mass flow rate through the collector loop. The input of the automatic controller with an inverter collector pump is given by a thermocouple input module that is connected to the embedded controller with the RS-485 communication protocol. In this work, the experiments were carried out on three different days, namely a clear day, an intermittently cloudy day and an overcast day, to evaluate the stability and the precision of the automatic controller, as well as the contribution of the useful heat gain from the collector for the solar-assisted heating system. Simulation and experimental results are also validated and analyzed.
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AbdelHaliem, Amr H., Mohammed A. Atiea, Mohammed E.Wahed, and Mohammed S. Metwally. "Application of Rough Sets to Predict the Breast Cancer Risk Association with Routine Blood Analyses." International Journal of Innovative Technology and Exploring Engineering 10, no. 3 (January 10, 2021): 67–72. http://dx.doi.org/10.35940/ijitee.b8235.0110321.
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For women around the globe, breast cancer has been a significant cause of mortality. Around the same time, early diagnosis and high cancer prediction precision are critical to improving the quality of care and the recovery rate of the patient. Expert systems and machine learning techniques are gaining prominence in this area as a result of efficient classification and high diagnostic ability. This paper introduces a model of hybrid prediction (RS QA) based on a rough set theoryand a quasi-optimal (AQ) rule induction algorithm. To find a minimal set of attributes that completely define the results, a rough set tool is used. The selected characteristics were collected, ensuring the high standard of the classification. Then to produce the decision rules, we use the quasi-optimal (AQ) rule induction algorithm. These hybrid prediction models allow expert systems to be built based on the conceptual rules of the IF/THEN sort. The suggested experiment is performed using the Coimbra Breast Cancer Dataset (BCCD) based on sets of measures that can be obtained in routine blood tests. Using classification precision, sensitivity, specificity, and receiver operating characteristics (ROC) curves, the efficiency of our suggested approach was assessed. Experimental results indicate the highest classification accuracy (91.7 percent), sensitivity (83.3 percent), and precision (94.3) obtained by the proposed (RS_QA) model.
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Wang, Lili, Jian Deng, Xuezhen Ji, Wanbin Liu, Jun Liang, Xiaona Yan, Dan Chen, and Jie Xie. "Chiral Separation of Racemic Naproxen by High-Performance Liquid Chromatography with β-CD/SiO2 as the Chiral Stationary Phase." Journal of AOAC INTERNATIONAL 97, no. 1 (January 1, 2014): 121–27. http://dx.doi.org/10.5740/jaoacint.12-200.
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Abstract A novel derivative β-cyclodextrin (β-CD) bonded silica gel (β-CD/SiO2) was prepared via carbodiimide activation and used as a chiral stationary phase (CSP). The β-CD/SiO2 CSP was characterizedby X-ray photoelectron spectroscopy and FTIR spectroscopy to prove the successful immobilization of β-CD onto the surface of the silica gel.The thermal behavior of the CSP was studied by differential scanning calorimetry and then used forthe chiral separation of racemic naproxen using HPLC. Several factors affecting the separation efficiency of naproxen enantiomers were investigatedsystematically. The following parameters were selected: methanol–0.01 M phosphate buffer solution (85 + 15, v/v, pH 3.5) was the mobile phase, the flow rate was 1.0 mL/min, and the column temperature was 35°C. Under optimal conditions, the racemic naproxen was efficiently separated with a resolution factor (RS) of 1.70 and a separation factor (α) of 1.25. This method was successfully used for the enantiomeric separation and purity assessment of naproxen in commercial naproxen sustained release tablets.
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Tsimberidou, Apostolia-Maria, William Wierda, William Plunkett, Susan O'Brien, Thomas J. Kipps, Jeffrey Alan Jones, Susan Smith, Annette Jalayer, Hagop M. Kantarjian, and Michael Keating. "Oxaliplatin, Fludarabine, Cytarabine, and Rituximab Combination Therapy Induces High Response Rates in Agressive Chronic Lymphocytic Leukemia (CLL) and Richter's Syndrome (RS)." Blood 114, no. 22 (November 20, 2009): 3443. http://dx.doi.org/10.1182/blood.v114.22.3443.3443.
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Abstract Abstract 3443 Poster Board III-331 Introduction The first Phase I-II clinical trial of oxaliplatin, fluradabine, cytarabine (Ara-C), and rituximab (OFAR1) demonstrated significant activity in refractory CLL and RS (Tsimberidou et al, J Clin Oncol, 2008;26:196). To enhance the response rate and decrease myelosuppression, the dose of oxaliplatin was increased to 30mg daily, the dose of Ara-C was decreased to 0.5g/m2 daily and the optimal number of days of fluradabine and Ara-C administration was explored (OFAR2). Methods In a Phase I-II study of OFAR2, patients were treated with oxaliplatin 30mg/m2, D1-4; fludarabine 30mg/m2, Ara-C 0.5g/m2; rituximab 375mg/m2, D3; and pelfigrastim 6mg, D6. Fludarabine and Ara-C were given on D2-3 (dose level 1) D2-4 (dose level 2) or D2-5 (dose level 3); courses were repeated every 4 weeks. Patients received prophylaxis for tumor lysis, DNA viruses, and PCP. A “3+3” design was used and the planned number of patients in the Phase II was 90 (CLL, 60; RS, 30). Results Ninety-one patients (CLL, 67; RS, 24) have been treated to date: Phase I, 12 patients (by dose level: 1, n=3; 2, n=6; and 3, n=3). DLTs were noted in 2 of 3 patients on dose level 3 (G4 diarrhea, 1; G4 neutropenic sepsis, 1); thus, dose level 2 was the MTD. Seventy-nine patients (relapsed CLL, 58; RS, 19) have been treated in the Phase II portion of the study. Patient characteristics were as follows: age > 60 years, 65%; 17p deletion, 38%; 11q deletion, 13%; 13q deletion, 16%; trisomy 12, 21%; no findings, 12%; unmutated IgVH, 80%; ZAP70-positive, 75%; and CD38 ≥30%, 58%. Response in patients treated in the Phase II recommended dose is shown in Table (evaluable, 67). The overall response rates in patients with 17p and 11q deletions were 48% and 55%, respectively. The median survival duration was 21 months (CLL, 21 months; RS, 9.5 months). At 18 months, the survival rates in patients with 17p and 11q deletions were 66% and 76%, respectively. Twelve patients underwent stem cell transplantation after OFAR2 (as post-remission therapy, n=10; as salvage, n=2). Overall, 196 cycles were administered. Grade 3-4 neutropenia, thrombocytopenia, and anemia were noted in 63%, 72%, and 39% of patients and in 57%, 70%, and 25% of cycles and Grade 3-4 infections in 19% of patients. Conclusion Preliminary results demonstrated that OFAR2 induced response in 40% of patients with RS and 63% of patients with relapsed/refractory CLL. OFAR2 had antileukemic activity in patients with 17p deletion. Clinical outcomes appeared to be superior to those of OFAR1 in refractory CLL, whereas results of OFAR1 appeared to be superior to those of OFAR2 in RS. Accrual is ongoing. Disclosures Tsimberidou: ASCO: ASCO Career Development Award; Sanofi: Research Funding. Off Label Use: Oxaliplatin is used off-label. Wierda:Genentech: Honoraria; Bayer, Sanofi-Aventis, Abbott, GSK: Research Funding; GSK, Trubion, Ligand, Genentech, Medimmune, Abbot: Consultancy; Celgene: Speakers Bureau. Plunkett:Sanofi-Aventis: Research Funding. O'Brien:Genentech: Research Funding; Sanofi: Consultancy. Kipps:NCI: Grant P01CA-81534.
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Wu, Yongjie, Wei Xu, Yongjie Piao, and Wei Yue. "Analysis of Edge Method Accuracy and Practical Multidirectional Modulation Transfer Function Measurement." Applied Sciences 12, no. 24 (December 12, 2022): 12748. http://dx.doi.org/10.3390/app122412748.
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The modulation transfer function (MTF) is commonly used as an imaging quality criterion reflecting the spatial resolution capability of imaging systems. The modified edge methods based on ISO Standard 12233 are widely used in MTF measurement for various imaging fields with high confidence. However, there are two problems in the existing edge methods which limit the application in remote sensing (RS) field with complicated image quality and usually uncontrollable edge angle: a near-horizontal or near-vertical “small tilt angle straight (STAS)” edge is required, and the MTF measurement results show low robustness and non-uniqueness. In this study, the influence of edge angle, oversampling rate (OSR), region of interest (ROI), edge contrast, and random noise on the edge method accuracy is quantitatively analyzed, and a practical multidirectional MTF measurement edge method is proposed based on the above analysis results. The modified edge method adaptively determines the optimal OSR according to edge angle and combines multiple measurement states, such as multi-ROI extraction and multi-phase binning, to improve the robustness, accuracy, and practicality of the edge method.
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Tsimberidou, Apostolia Maria, William G. Wierda, Sijin Wen, William Plunkett, Susan O'Brien, Thomas J. Kipps, Jeffrey A. Jones, Hagop M. Kantarjian, and Michael J. Keating. "Results of a Phase I-II Clinical Trial of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab (OFAR) Combination Therapy In Patients with Aggressive, Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Richter Syndrome (RS)." Blood 116, no. 21 (November 19, 2010): 923. http://dx.doi.org/10.1182/blood.v116.21.923.923.
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Abstract Abstract 923 Background: To enhance the response rate with a decrease in myelosuppression that were observed with oxaliplatin, fluradabine, Ara-C, and rituximab (OFAR1) (Tsimberidou et al, J Clin Oncol, 2008;26:196), the daily dose of oxaliplatin was increased from 25 to 30mg, the daily dose of Ara-C was decreased from 1 g/m2 to 0.5 g/m2 and the optimal number of days of fluradabine and Ara-C administration was explored (OFAR2). Methods: OFAR2 consisted of oxaliplatin 30mg/m2 D1-4; fludarabine 30mg/m2; Ara-C 0.5g/m2; rituximab 375mg/m2 D3; and pelfigrastim 6mg D6. Fludarabine and Ara-C were given on D2-3 (level 1) D2-4 (level 2) or D2-5 (level 3) every 4 weeks. Tumor lysis, DNA virus, and PCP prophylaxis was administered. A “3+3” design was used (Phase I) and and the planned number of patients in the Phase II was 90 (CLL, 60; RS, 30). Results: Overall 102 patients (rel. CLL 67, RS 35) were treated. Twelve patients were treated in the Phase I portion of the study. Dose-limiting toxicities were noted in 2/3 patients at level 3 (G4 diarrhea and G4 sepsis). Level 2 was the maximum tolerated dose. Ninety patients (CLL, 60; RS, 30) were treated in Phase II portion of the study (age > 60 years 67%, 17p del 37.5%, 11q del 15%, 13q del 18%, +12, 17%; neg. 12.5%; unmutated IgVH 81.5%, ZAP70-positive 77%, and CD38 30%, 63%). Response in 80 of 90 patients (Phase II) is shown in Table (too early, n=10). The overall response rates in patients (Phase II) with 17p deletion and 11q deletion were 29% and 41%, respectively. Twenty-nine patients underwent SCT after OFAR2 (response status to OFAR2 at the time of SCT: CR, n=3; nPR, n=2; 15; no response, n=9). With a median follow-up of 20.8 months, the median survival was 19 months (95% CI, 13–37+) and the median FFS was 6 months (95% CI, 3.4 – 8.2). Overall, 238 cycles were administered. G3-4 neutropenia, thrombocytopenia, and anemia were noted in 67%, 74%, and 44% of patients (51%, 64%, and 25% of cycles); and G3-4 infections in 19% of patients. Clinical outcomes of OFAR2 were compared with those of OFAR1. In patients with RS, the overall response rate was 41% (11/27) with OFAR2 and 50% (10/20) with OFAR1 (p = 0.57, Fisher's test); the median survival with OFAR2 and OFAR1 was 8.3 months and 18+ months, respectively (p = 0.92, log-rank test); and the respective median FFS was 3.0 months and 4.1 months (p = 0.40, log-rank test). In patients with CLL, the overall response rate was 55% (29/53) with OFAR2 and 33% (10/30) with OFAR1 (p = 0.36, Fisher's test); the median survival with OFAR2 was 21.4 months and 13.8 months with OFAR1 (p = 0.19, log-rank test); and the respective median FFS was 6.6 months and 4.9 months (p = 0.69, log-rank test). Conclusion: OFAR2 induced response in 41% of patients with RS and 55% of patients with relapsed/refractory CLL in the phase II study. Antileukemic activity was also noted in patients with 17p deletion. Although the numbers of patients are small, OFAR1 was associated with a trend towards superior clinical outcomes in patients with RS compared to OFAR2; and OFAR2 was associated with a trend towards superior clinical outcomes compared to OFAR1 in patients with relapsed/refractory CLL. Disclosures: Tsimberidou: Sanofi: Membership on an entity's Board of Directors or advisory committees, Research Funding; ASCO: Career Development Award, Research Funding. Off Label Use: Drug: Oxaliplatin. Oxaliplatin combined with fludarabine, cytarabine, and rituximab has antileukemic activity in patients with relapsed/refractory Chronic Lymphocytic Leukemia and Richter Syndrome. Wierda:Genentech: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Micromet: Consultancy, Membership on an entity's Board of Directors or advisory committees; GlaxoSmithKline: Research Funding; Abbott Laboratories: Research Funding. O'Brien:Biogen Idec: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Genentech: Consultancy, Research Funding. Kipps:Sanofi Aventis: Research Funding. Jones:GlaxoSmithKline: Consultancy, Membership on an entity's Board of Directors or advisory committees; Abbott Laboratories: Research Funding.
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Zhang, Xinhe, Wenbo Lv, and Haoran Tan. "Low-Complexity GSM Detection Based on Maximum Ratio Combining." Future Internet 14, no. 5 (May 23, 2022): 159. http://dx.doi.org/10.3390/fi14050159.
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Generalized spatial modulation (GSM) technology is an extension of spatial modulation (SM) technology, and one of its main advantages is to further improve band efficiency. However, the multiple active antennas for transmission also brings the demodulation difficulties at the receiver. To solve the problem of high computational complexity of the optimal maximum likelihood (ML) detection, two sub-optimal detection algorithms are proposed through reducing the number of transmit antenna combinations (TACs) detected at the receiver. One is the maximum ratio combining detection algorithm based on repetitive sorting strategy, termed as (MRC-RS), which uses MRC repetitive sorting strategy to select the most likely TACs in detection. The other is the maximum ratio combining detection algorithm, which is based on the iterative idea of the orthogonal matching pursuit, termed the MRC-MP algorithm. The MRC-MP algorithm reduces the number of TACs through finite iterations to reduce the computational complexity. For M-QAM constellation, a hard-limited maximum likelihood (HLML) detection algorithm is introduced to calculate the modulation symbol. For the M-PSK constellation, a low-complexity maximum likelihood (LCML) algorithm is introduced to calculate the modulation symbol. The computational complexity of these two algorithms for calculating the modulation symbol are independent of modulation order. The simulation results show that for GSM systems with a large number of TACs, the proposed two algorithms not only achieve almost the same bit error rate (BER) performance as the ML algorithm, but also can greatly reduce the computational complexity.
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Puspita Sari, Indah Mutiara, Sutopo Patria Jati, and Septo Pawelas Arso. "ANALISIS PENDEKATAN PERILAKU ORGANISASI DALAM KENDALI MUTU DAN KENDALI BIAYA SELAMA PANDEMI COVID-19 DI RS SWASTA X KOTA SEMARANG." VISIKES: Jurnal Kesehatan Masyarakat 22, no. 1 (May 10, 2023): 148–63. http://dx.doi.org/10.33633/visikes.v22i1supp.7218.
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ABSTRACTThere was a decrease in quality and cost recovery rate at Private Hospital X Semarang City during the COVID-19 pandemic. Hospitals must implement Quality Control and Cost Control during the COVID-19 pandemic. Hospitals need an understanding of organizational behavior management to optimize Quality Control and Cost Control. Therefore, this study aims to analyze the organizational behavior in quality control and cost control during the COVID-19 pandemic at Private Hospital X Semarang City. This study uses a qualitative method. The organizational behavior analysis by analyzing input, process, and outcomes aspects. Qualitative data collection using in-depth interviews. Informants were determined by purposive sampling. The mains informants consisted of three and three triangulated informants. Data analysis used the method of content analysis (content analysis) by triangulating sources and methods. The results showed that the input aspects were still lacking because they did not have detailed task descriptions understood by the team and had not made guidelines and Standard Operating Procedures (SPO) related to the implementation of quality control and cost control. The process aspects are still lacking because communication is not optimal, leadership has never conducted monitoring evaluations, and team conflicts still occur due to communication and clinical pathway non-compliance. As a result, the outcomes in organizational behavior are still not good, as seen from the lack of cohesion and the function of the quality control and cost control teams who have not carried out scheduled and routine medical audits, and have not carried out utilization.Keywords: The Organizational Behavior, Quality Control, Quality Cost, Hospital, Pandemic COVID-19
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Marcos González, Sara, Emilio Rodrigo Calabia, Ignacio Varela, Michal Červienka, Javier Freire Salinas, and José Javier Gómez Román. "High Rate of Mutations of Adhesion Molecules and Extracellular Matrix Glycoproteins in Patients with Adult-Onset Focal and Segmental Glomerulosclerosis." Biomedicines 11, no. 6 (June 20, 2023): 1764. http://dx.doi.org/10.3390/biomedicines11061764.
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(1) Background: Focal and segmental glomerulosclerosis (FSGS) is a pattern of injury that results from podocyte loss in the setting of a wide variety of injurious mechanisms. These include both acquired and genetic as well as primary and secondary causes, or a combination thereof, without optimal therapy, and a high rate of patients develop end-stage renal disease (ESRD). Genetic studies have helped improve the global understanding of FSGS syndrome; thus, we hypothesize that patients with primary FSGS may have underlying alterations in adhesion molecules or extracellular matrix glycoproteins related to previously unreported mutations that may be studied through next-generation sequencing (NGS). (2) Methods: We developed an NGS panel with 29 genes related to adhesion and extracellular matrix glycoproteins. DNA was extracted from twenty-three FSGS patients diagnosed by renal biopsy; (3) Results: The average number of accumulated variants in FSGS patients was high. We describe the missense variant ITGB3c.1199G>A, which is considered pathogenic; in addition, we discovered the nonsense variant CDH1c.499G>T, which lacks a Reference SNP (rs) Report and is considered likely pathogenic. (4) Conclusions: To the best of our knowledge, this is the first account of a high rate of change in extracellular matrix glycoproteins and adhesion molecules in individuals with adult-onset FSGS. The combined effect of all these variations may result in a genotype that is vulnerable to the pathogenesis of glomerulopathy.
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Tsimberidou, A. M., W. G. Wierda, W. K. Plunkett, S. O'Brien, S. Lerner, S. C. Smith, H. M. Kantarjian, and M. J. Keating. "Phase I/II study of oxaliplatin, fludarabine, cytarabine, and rituximab in patients (OFAR2) with Richter's syndrome (RS), and relapsed or refractory B-cell chronic lymphocytic leukemia (CLL)." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 7031. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.7031.
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7031 Background: The first Phase I-II clinical trial of oxaliplatin, fluradabine, Ara-C, and rituximab (OFAR1) demonstrated significant activity in refractory CLL and RS (Tsimberidou et al, J Clin Oncol, 2008;26:196). To enhance the response rate with a decrease in myelosuppression, the dose of oxaliplatin was increased to 30 mg daily, the dose of Ara-C was decreased to 0.5g/m2 daily and the optimal number of days of fluradabine and Ara-C administration was explored (OFAR2). Methods: The OFAR2 regimen consisted of oxaliplatin 30mg/m2, D1–4; fludarabine 30mg/m2, Ara-C 0.5 g/m2; rituximab 375mg/m2, D3; and pelfigrastim 6mg D6. Fludarabine and Ara-C were given on D2–3 (dose level 1) D2–4 (dose level 2) or D2–5 (dose level 3); courses were repeated every 4 wks. Prophylaxis for tumor lysis, DNA viruses, and PCP was given. Results: A total of 55 pts have been treated to date: 12 pts enrolled in phase I (dose level 1, n=3; dose level 2, n=6; and dose level 3, n=3). DLTs were noted in 2/3 pts in dose level 3 (G4 diarrhea, 1; G4 neutropenic sepsis, 1), therefore level 2 was the MTD. Forty-three pts were treated in the Phase II portion of the study (relapsed CLL, 35; RS, 8). The median age was 64 yrs (range, 40- 81); 50 (91%) had β2-microglobulin > 3 mg/L; platelets were < 100 x109/L in 22 pts; and 44 pts had > 1 prior therapies. FISH results were: 17p deletion, n=15; 11q del, n=7; trisomy 12, n=12; 13q del, n=8; normal, n=2; unknown, n=11. Overall, 33 pts had unmutated and 7 mutated IgVH gene; ZAP70 was positive in 30, and negative in 14. Six (46%) of 13 pts with 17p del by FISH responded to OFAR2 (nPR, 2; PR, 4). Eleven pts underwent stem cell transplantation as postremission or salvage therapy. The most common toxicity was myelosuppression. Conclusions: Preliminary results demonstrated that OFAR2 resulted in an overall response rate of 63%, had antileukemic activity in pts with 17p del and clinical outcomes appeared to be superior to those of OFAR1. Accrual is ongoing. [Table: see text] [Table: see text]
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Rachmawan, Dicky, Francisia Saveria Sika Ery Seda, Robert Siburian, and Danang Kuncara Sakti. "Manfaat, Pandangan, Dan Alternatif Program Perhutanan Sosial Di Dua Kelompok Rujukan, Kabupaten Pemalang." Jurnal Penelitian Sosial dan Ekonomi Kehutanan 19, no. 1 (September 20, 2022): 29–41. http://dx.doi.org/10.20886/jpsek.2022.19.1.29-41.
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Social forestry program expected to give space for people in forest management, improve livelihood, and conserve the environment at once to decrease poverty rate on people who live around the forest. This article aims to describe the benefit of community member which is complemented by deepening of view and alternative of social forestry program in Kelompok Tani Hutan Gunung Gajah Lestari (KTH GGL) and Lembaga Masyarakat Desa Hutan Rawa Sakti (LMDH RS). Qualitative approach in case study form is used which interview 49 informants include managements and members that accompanied by focus group discussion as data triangulation which processed by Nvivo application and Microsoft Excel. The result shows social forestry program has viewed giving benefit although it felt not optimal by the members in both groups. However, rough calculation on utilization of forest areas tends possibly to contribute around Rp.1,5-3 million rupiah/planting period. The utilization of forest areas is revival means or additional income where social-economic context is needed to be understood on identify commodity alternative that can be developed in the further time. The rest is the need for natural science approach which can answer the confusion of community to find alternatives commodity which more give revenue.
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Mur, Raquel, Elisa Langa, M. Rosa Pino-Otín, José S. Urieta, and Ana M. Mainar. "Concentration of Antioxidant Compounds from Calendula officinalis through Sustainable Supercritical Technologies, and Computational Study of Their Permeability in Skin for Cosmetic Use." Antioxidants 11, no. 1 (December 30, 2021): 96. http://dx.doi.org/10.3390/antiox11010096.
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The growing interest in the cosmetic industry in using compounds of natural and sustainable origin that are safe for humans is encouraging the development of processes that can satisfy these needs. Chlorogenic acid (CHA), caffeic acid (CAF) and ferulic acid (FA) are three compounds widely used within the cosmetic industry due to their functionalities as antioxidants, collagen modifiers or even as radiation protectors. In this work, two advanced separation techniques with supercritical CO2 are used to obtain these three compounds from Calendula officinalis, and these are then evaluated using a computational skin permeability model. This model is encompassed by the COSMO-RS model, the calculations of which make it possible to study the behaviour of the compounds in the epidermis. The results show that both CAF and FA are retained in the stratum corneum, while CHA manages to penetrate to the stratum spinosum. These compounds were concentrated by antisolvent fractionation with super-critical CO2 using a Response Surface Methodology to study the effect of pressure and CO2 flow rate. CHA, CAF and FA were completely retained in the precipitation vessel, with concentrations between 40% and 70% greater than in the original extract. The conditions predicted that the optimal overall yield and enrichment achieved would be 153 bar and 42 g/min.
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Santos, Natalia G. P., Deyber A. V. Medina, and Fernando M. Lanças. "Development of Wall-Coated Open Tubular Columns and Their Application to Nano Liquid Chromatography Coupled to Tandem Mass Spectrometry." Molecules 28, no. 13 (June 29, 2023): 5103. http://dx.doi.org/10.3390/molecules28135103.
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This work presents a study on the application of wall open tubular column (WCOT) in liquid chromatography coupled with tandem mass spectrometry. Each process step reports the column preparation method in detail, subdivided into column pretreatment, silanization, stationary phase coating, and immobilization. Then, an evaluation of the parameters that can affect the efficiency of these columns was made. Atrazine, clomazone, and metolachlor were used as probes during this step. Factors such as stationary phase composition, length, internal diameter, stationary phase mass employed, and injection volume were investigated. In addition, with the help of Knox and Poppe graphs, the columns’ performance was evaluated to determine the optimal flow rate and the speed-efficiency relationship, respectively. Based on the results, the best configurations for the WCOT column application to the LC system were defined: length—8 m; inner diameter—25 μm; mass of OV-210—2.5% m/v; and, injection volume—100 nL. Finally, the optimized WCOT column developed in this work was coupled with a commercially-packed trapping column in the nano liquid chromatography system (nanoLC). In this configuration, more significant results were obtained regarding separation resolution, with Rs = 5.9 achieved for the most retained pair of analytes (clomazone and metolachlor).
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Hasibuan, Winarty Natalia, Muhammad Ardian Cahya L, and Budiono Budiono. "EARLY MANAGEMENT OF SEVERE PRE-ECLAMPTIC AND ECLAMPTIC REFFERAL PATIENT AT KOTABARU REGENCY." Indonesian Midwifery and Health Sciences Journal 4, no. 2 (October 11, 2021): 98–108. http://dx.doi.org/10.20473/imhsj.v4i2.2020.98-108.
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ABSTRACTBackground: The maternal mortality rate is 305 per 100,000 live births in Indonesia. The most common cause of maternal death is preeclampsia / eclampsia. The maternal mortality rate is 247 per 100,000 live births in 2017 in Kotabaru Regency. Most preeclamptic referral patients are in critical condition when they arrive at the hospital. Method: This type of research is an observational descriptive study. The population is all patients with severe preeclampsia and eclampsia in the delivery room of RS Pangeran Jaya Sumitra Kabupaten Kotabaru from January - December 2018. The sample is total sampling.Results: PEB referral patients was 57 cases. Most of those are in the group age of 20 - 35 years which are 35 people (61.4%), not nullipara is 31 people (54,4%), 34-40 weeks of gestation is 43 people (75,4%), as many as 44 people (77,2%) with previous severe preeclampsia/ hypertension, 41 people (71,9%) brought referral letters, referred by Puskesmas are 47 people (82.5%), most of the locations of referral is from Pulau Laut as many as 35 referrals (61,4%). The initial management of PEB and eclampsia: IV Pathway in 11 patients (19.3%) of severe preeclamptic and eclamptic patients, 50 patients (87.7%) were not given MgSO4, 51 people (89.5% ) did not get anti-hypertension, 52 patients (91.2%) were not installed catheters. Conclusion: Early management of severe preeclamptic and eclamptic patients is not optimal and does not fulfil the standard yet. Proper and appropriate early management can reduce morbidity and maternal mortality from complications of severe preeclampsia and eclampsia that can be prevented by providing right initial management.
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Ahmed, Muqeem, Mohd Dilshad Ansari, Ninni Singh, Vinit Kumar Gunjan, Santhosh Krishna B. V., and Mudassir Khan. "Rating-Based Recommender System Based on Textual Reviews Using IoT Smart Devices." Mobile Information Systems 2022 (July 11, 2022): 1–18. http://dx.doi.org/10.1155/2022/2854741.
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Recommender system (RS) is a unique type of information clarification system that anticipates the user's evaluation of items from a large pool based on the expectations of a single stakeholder. The proposed system is highly useful for getting expected meaning suggestions and guidance for choosing the proper product using artificial intelligence and IoT (Internet of Things) such as chatbot. The current proposed technique makes it easier for stakeholders to make context-based decisions that are optimal rather than reactive, such as which product to buy, news classification based on high filtering views, highly recommended wanted music to choose, and desired product to choose. Recommendation systems are a critical tool for obtaining verified information and making accurate decisions. As a result, operational efficiency would skyrocket, and the risk to the company that uses a recommender system would plummet. This proposed solution can be used in a variety of applications such as commercial hotels OYO and other hotels, hospitals (GYAN), public administrative applications banks HDFC, and ICICI to address potential questions on the spot using intelligence computing as a recommendation system. The existing RS is considering a few factors such as buying records, classification or clustering items, and user's geographic location. Collaborative filtering algorithms (CFAs) are much more common approaches for cooperating to mesh the respective documents they retrieved from the historical data. CFAs are distinguished in plenty of features that are uncommon from other algorithms. In this existing system classification, precision and efficiency and error rate are statistical measurements that need to be enhanced according to the current need to fit for global requirements. The proposed work deals with enhancing accuracy levels of text reviews with the recommender system while interacting by the numerous users for their domains. The authors implemented the recommender system using a user-based CF method and presented the significance of collaborative filtering on the movie domain with a recommender system. This whole experiment has been implanted using the RapidMiner Java-based tool. Results have been compared with existing algorithms to differentiate the efficiency of the current proposed approach.
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Rondinelli, Maria Beatrice, Luca Paolo Weltert, Giovanni Ruocco, Matteo Ornelli, Pietro Francesco Delle Femmine, Alessandro De Rosa, Luca Pierelli, and Nicola Felici. "Patient Blood Management in Microsurgical Procedures for Reconstructive Surgery." Diagnostics 13, no. 17 (August 25, 2023): 2758. http://dx.doi.org/10.3390/diagnostics13172758.
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Introduction: The main purpose of reconstructive surgery (RS) is to restore the integrity of soft tissues damaged by trauma, surgery, congenital deformity, burns, or infection. Microsurgical techniques consist of harvesting tissues that are separated from the vascular sources of the donor site and anastomosed to the vessels of the recipient site. In these procedures, there are some preoperative modifiable factors that have the potential to influence the outcome of the flap transfer and its anastomosis. The management of anemia, which is always present in the postoperative period and plays a decisive role in the implantation of the flap, covers significant importance, and is associated with clinical and laboratory settings of chronic inflammation. Methods: Chronic inflammatory anemia (ACD) is a constant condition in patients who have undergone RS and correlates with the perfusion of the free flap. The aim of this treatment protocol is to reduce the transfusion rate by maintaining both a good organ perfusion and correction of the patient’s anemic state. From January 2017 to September 2019, we studied 16 patients (16 males, mean age 38 years) who underwent microsurgical procedures for RS. Their hemoglobin (Hb) levels, corpuscular indexes, transferrin saturation (TSAT) ferritin concentrations and creatinine clearance were measured the first day after surgery (T0), after the first week (T1), and after five weeks (T2). At T0, all the patients showed low hemoglobin levels (average 7.4 g/dL, STD 0.71 range 6.2–7.4 g dL−1), with an MCV of 72, MCH of 28, MCHC of 33, RDW of 16, serum iron of 35, ferritin of 28, Ret% of 1.36, TRF of 277, creatinine clearance of 119 and high ferritin levels (range 320–560 ng mL−1) with TSAT less than 20%. All the patients were assessed for their clinical status, medical history and comorbidities before the beginning of the therapy. Results: A collaboration between the two departments (Department of Transfusion Medicine and Department of Reconstructive Surgery) resulted in the application of a therapeutic protocol with erythropoietic stimulating agents (ESAs) (Binocrit 6000 UI/week) and intravenous iron every other day, starting the second day after surgery. Thirteen patients received ESAs and FCM (ferric carboxymaltose, 500–1000 mg per session), three patients received ESAs and iron gluconate (one vial every other day). No patients received blood transfusions. No side effects were observed, and most importantly, no limb or flap rejection occurred. Conclusions: Preliminary data from our protocol show an optimal therapeutic response, notwithstanding the very limited scientific literature and data available in this specific surgical field. The enrollment of further patients will allow us to validate this therapeutic protocol with statistically sound data.