Journal articles on the topic 'Ras proteins'
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Takács, Tamás, Gyöngyi Kudlik, Anita Kurilla, Bálint Szeder, László Buday, and Virag Vas. "The effects of mutant Ras proteins on the cell signalome." Cancer and Metastasis Reviews 39, no. 4 (July 9, 2020): 1051–65. http://dx.doi.org/10.1007/s10555-020-09912-8.
Full textJelinek, T., P. Dent, T. W. Sturgill, and M. J. Weber. "Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation." Molecular and Cellular Biology 16, no. 3 (March 1996): 1027–34. http://dx.doi.org/10.1128/mcb.16.3.1027.
Full textBhattacharya, M., A. V. Babwah, and S. S. G. Ferguson. "Small GTP-binding protein-coupled receptors." Biochemical Society Transactions 32, no. 6 (October 26, 2004): 1040–44. http://dx.doi.org/10.1042/bst0321040.
Full textTang, Yi, Jong Yu, and Jeffrey Field. "Signals from the Ras, Rac, and Rho GTPases Converge on the Pak Protein Kinase in Rat-1 Fibroblasts." Molecular and Cellular Biology 19, no. 3 (March 1, 1999): 1881–91. http://dx.doi.org/10.1128/mcb.19.3.1881.
Full textGoi, Takanori, Gabriel Rusanescu, Takeshi Urano, and Larry A. Feig. "Ral-Specific Guanine Nucleotide Exchange Factor Activity Opposes Other Ras Effectors in PC12 Cells by Inhibiting Neurite Outgrowth." Molecular and Cellular Biology 19, no. 3 (March 1, 1999): 1731–41. http://dx.doi.org/10.1128/mcb.19.3.1731.
Full textReddy, E. Premkumar, Sai Krishna Divakar, Rodrigo Vasquez-Del Carpio, Kaushik Dutta, Stacey J. Baker, Ramana Reddy, and Aneel K. Aggarwal. "Rigosertib Blocks RAS Signaling By Acting As a Small Molecule RAS Mimetic That Binds to the RAS-Binding Domains of RAS Effector Proteins." Blood 124, no. 21 (December 6, 2014): 5616. http://dx.doi.org/10.1182/blood.v124.21.5616.5616.
Full textRamocki, M. B., S. E. Johnson, M. A. White, C. L. Ashendel, S. F. Konieczny, and E. J. Taparowsky. "Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis." Molecular and Cellular Biology 17, no. 7 (July 1997): 3547–55. http://dx.doi.org/10.1128/mcb.17.7.3547.
Full textStang, S., D. Bottorff, and J. C. Stone. "Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells." Molecular and Cellular Biology 17, no. 6 (June 1997): 3047–55. http://dx.doi.org/10.1128/mcb.17.6.3047.
Full textTang, Y., Z. Chen, D. Ambrose, J. Liu, J. B. Gibbs, J. Chernoff, and J. Field. "Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts." Molecular and Cellular Biology 17, no. 8 (August 1997): 4454–64. http://dx.doi.org/10.1128/mcb.17.8.4454.
Full textKELLEY, Grant G., Sarah E. REKS, and Alan V. SMRCKA. "Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins." Biochemical Journal 378, no. 1 (February 15, 2004): 129–39. http://dx.doi.org/10.1042/bj20031370.
Full textHall, Alan. "Ras-related proteins." Current Opinion in Cell Biology 5, no. 2 (April 1993): 265–68. http://dx.doi.org/10.1016/0955-0674(93)90114-6.
Full textGraham, S. M., A. B. Vojtek, S. Y. Huff, A. D. Cox, G. J. Clark, J. A. Cooper, and C. J. Der. "TC21 causes transformation by Raf-independent signaling pathways." Molecular and Cellular Biology 16, no. 11 (November 1996): 6132–40. http://dx.doi.org/10.1128/mcb.16.11.6132.
Full textKhosravi-Far, R., M. A. White, J. K. Westwick, P. A. Solski, M. Chrzanowska-Wodnicka, L. Van Aelst, M. H. Wigler, and C. J. Der. "Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation." Molecular and Cellular Biology 16, no. 7 (July 1996): 3923–33. http://dx.doi.org/10.1128/mcb.16.7.3923.
Full textPrior, I. A., and J. F. Hancock. "Compartmentalization of Ras proteins." Journal of Cell Science 114, no. 9 (May 1, 2001): 1603–8. http://dx.doi.org/10.1242/jcs.114.9.1603.
Full textBeranger, F., H. Paterson, S. Powers, J. de Gunzburg, and J. F. Hancock. "The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization." Molecular and Cellular Biology 14, no. 1 (January 1994): 744–58. http://dx.doi.org/10.1128/mcb.14.1.744-758.1994.
Full textBeranger, F., H. Paterson, S. Powers, J. de Gunzburg, and J. F. Hancock. "The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization." Molecular and Cellular Biology 14, no. 1 (January 1994): 744–58. http://dx.doi.org/10.1128/mcb.14.1.744.
Full textMarty, Caroline, Darren D. Browning, and Richard D. Ye. "Identification of Tetratricopeptide Repeat 1 as an Adaptor Protein That Interacts with Heterotrimeric G Proteins and the Small GTPase Ras." Molecular and Cellular Biology 23, no. 11 (June 1, 2003): 3847–58. http://dx.doi.org/10.1128/mcb.23.11.3847-3858.2003.
Full textCox, A. D., M. M. Hisaka, J. E. Buss, and C. J. Der. "Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein." Molecular and Cellular Biology 12, no. 6 (June 1992): 2606–15. http://dx.doi.org/10.1128/mcb.12.6.2606-2615.1992.
Full textCox, A. D., M. M. Hisaka, J. E. Buss, and C. J. Der. "Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein." Molecular and Cellular Biology 12, no. 6 (June 1992): 2606–15. http://dx.doi.org/10.1128/mcb.12.6.2606.
Full textSimanshu, Dhirendra K. "Abstract IA05: Uncovering new structural insights into RAS interactions with effectors and regulators." Molecular Cancer Research 21, no. 5_Supplement (May 1, 2023): IA05. http://dx.doi.org/10.1158/1557-3125.ras23-ia05.
Full textDent, P., D. B. Reardon, D. K. Morrison, and T. W. Sturgill. "Regulation of Raf-1 and Raf-1 mutants by Ras-dependent and Ras-independent mechanisms in vitro." Molecular and Cellular Biology 15, no. 8 (August 1995): 4125–35. http://dx.doi.org/10.1128/mcb.15.8.4125.
Full textTong, L., M. Milburn, A. de Vos, and S. Kim. "Structure of ras proteins." Science 245, no. 4915 (July 21, 1989): 244. http://dx.doi.org/10.1126/science.2665078.
Full textChardin, Pierre. "The ras superfamily proteins." Biochimie 70, no. 7 (July 1988): 865–68. http://dx.doi.org/10.1016/0300-9084(88)90226-x.
Full textRowinsky, Eric K., Jolene J. Windle, and Daniel D. Von Hoff. "Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development." Journal of Clinical Oncology 17, no. 11 (November 1999): 3631–52. http://dx.doi.org/10.1200/jco.1999.17.11.3631.
Full textLi, Weiquan, Min Han, and Kun-Liang Guan. "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf." Genes & Development 14, no. 8 (April 15, 2000): 895–900. http://dx.doi.org/10.1101/gad.14.8.895.
Full textMolzan, Manuela, Benjamin Schumacher, Corinna Ottmann, Angela Baljuls, Lisa Polzien, Michael Weyand, Philipp Thiel, et al. "Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling." Molecular and Cellular Biology 30, no. 19 (August 2, 2010): 4698–711. http://dx.doi.org/10.1128/mcb.01636-09.
Full textSealover, Nancy, Bridget Finniff, and Robert Kortum. "Abstract B033: Wild-type RAS signaling is an essential therapeutic target in RAS-mutated cancers." Molecular Cancer Research 21, no. 5_Supplement (May 1, 2023): B033. http://dx.doi.org/10.1158/1557-3125.ras23-b033.
Full textLoirand, Gervaise, Vincent Sauzeau, and Pierre Pacaud. "Small G Proteins in the Cardiovascular System: Physiological and Pathological Aspects." Physiological Reviews 93, no. 4 (October 2013): 1659–720. http://dx.doi.org/10.1152/physrev.00021.2012.
Full textTakai, Yoshimi, Takuya Sasaki, and Takashi Matozaki. "Small GTP-Binding Proteins." Physiological Reviews 81, no. 1 (January 1, 2001): 153–208. http://dx.doi.org/10.1152/physrev.2001.81.1.153.
Full textNagahama, Masahiro, Akiko Ohkubo, Masataka Oda, Keiko Kobayashi, Katsuhiko Amimoto, Kazuaki Miyamoto, and Jun Sakurai. "Clostridium perfringensTpeL Glycosylates the Rac and Ras Subfamily Proteins." Infection and Immunity 79, no. 2 (November 22, 2010): 905–10. http://dx.doi.org/10.1128/iai.01019-10.
Full textSingh, Swati, and Matthew J. Smith. "RAS GTPase signalling to alternative effector pathways." Biochemical Society Transactions 48, no. 5 (October 14, 2020): 2241–52. http://dx.doi.org/10.1042/bst20200506.
Full textDay, Gwo-Jen, Raymond D. Mosteller, and Daniel Broek. "Distinct Subclasses of Small GTPases Interact with Guanine Nucleotide Exchange Factors in a Similar Manner." Molecular and Cellular Biology 18, no. 12 (December 1, 1998): 7444–54. http://dx.doi.org/10.1128/mcb.18.12.7444.
Full textSandoval, Carolina Ortiz, and Thomas Simmen. "Rab proteins of the endoplasmic reticulum: functions and interactors." Biochemical Society Transactions 40, no. 6 (November 21, 2012): 1426–32. http://dx.doi.org/10.1042/bst20120158.
Full textWilliams, Thomas D., Peggy I. Paschke, and Robert R. Kay. "Function of small GTPases in Dictyostelium macropinocytosis." Philosophical Transactions of the Royal Society B: Biological Sciences 374, no. 1765 (December 17, 2018): 20180150. http://dx.doi.org/10.1098/rstb.2018.0150.
Full textZondag, Gerben C. M., Eva E. Evers, Jean P. ten Klooster, Lennert Janssen, Rob A. van der Kammen, and John G. Collard. "Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition." Journal of Cell Biology 149, no. 4 (May 15, 2000): 775–82. http://dx.doi.org/10.1083/jcb.149.4.775.
Full textGoldfinger, Lawrence E., Celeste Ptak, Erin D. Jeffery, Jeffrey Shabanowitz, Donald F. Hunt, and Mark H. Ginsberg. "RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration." Journal of Cell Biology 174, no. 6 (September 11, 2006): 877–88. http://dx.doi.org/10.1083/jcb.200603111.
Full textBolomsky, Arnold, and Ryan M. Young. "Abstract A037: Oncogenic RAS signals from lysosomes to activate mTORC1 in multiple myeloma." Molecular Cancer Research 21, no. 5_Supplement (May 1, 2023): A037. http://dx.doi.org/10.1158/1557-3125.ras23-a037.
Full textRusanescu, Gabriel, Takaya Gotoh, Xuejun Tian, and Larry A. Feig. "Regulation of Ras Signaling Specificity by Protein Kinase C." Molecular and Cellular Biology 21, no. 8 (April 15, 2001): 2650–58. http://dx.doi.org/10.1128/mcb.21.8.2650-2658.2001.
Full textChakraborty, Atanu, Emily Linnane, and Sarah Ross. "Ras proteins as therapeutic targets." Biochemical Society Transactions 46, no. 5 (August 28, 2018): 1303–11. http://dx.doi.org/10.1042/bst20170529.
Full textSimanshu, Dhirendra K., and Deborah K. Morrison. "A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation." Cancer Discovery 12, no. 4 (January 19, 2022): 899–912. http://dx.doi.org/10.1158/2159-8290.cd-21-1494.
Full textGraham, Timothy E., Janet R. Pfeiffer, Rebecca J. Lee, Donna F. Kusewitt, A. Marina Martinez, Terry Foutz, Bridget S. Wilson, and Janet M. Oliver. "MEK and ERK Activation in Ras-Disabled RBL-2H3 Mast Cells and Novel Roles for Geranylgeranylated and Farnesylated Proteins in FcεRI-Mediated Signaling." Journal of Immunology 161, no. 12 (December 15, 1998): 6733–44. http://dx.doi.org/10.4049/jimmunol.161.12.6733.
Full textTherachiyil, Lubna, Anjana Anand, Abdullah Azmi, Ajaz Bhat, Hesham Korashy, and Shahab Uddin. "Role of RAS signaling in ovarian cancer." F1000Research 11 (November 4, 2022): 1253. http://dx.doi.org/10.12688/f1000research.126337.1.
Full textLightstone, Felice C., and Timothy S. Carpenter. "Abstract A015: Dynamics and lipid interactions of the RAS-RBD-CRD protein complex." Molecular Cancer Research 21, no. 5_Supplement (May 1, 2023): A015. http://dx.doi.org/10.1158/1557-3125.ras23-a015.
Full textRoy, Sandrine, Bruce Wyse, and John F. Hancock. "H-Ras Signaling and K-Ras Signaling Are Differentially Dependent on Endocytosis." Molecular and Cellular Biology 22, no. 14 (July 15, 2002): 5128–40. http://dx.doi.org/10.1128/mcb.22.14.5128-5140.2002.
Full textHolstein, Sarah A., Christine L. Wohlford-Lenane, and Raymond J. Hohl. "Isoprenoids Influence Expression of Ras and Ras-Related Proteins†." Biochemistry 41, no. 46 (November 2002): 13698–704. http://dx.doi.org/10.1021/bi026251x.
Full textYuan, Wanqiong, and Chunli Song. "The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways." Biochemistry Research International 2020 (February 11, 2020): 1–10. http://dx.doi.org/10.1155/2020/4186308.
Full textSealover, Nancy E., and Robert L. Kortum. "Abstract 413: WT RAS signaling is an essential therapeutic target in RAS mutated cancers." Cancer Research 82, no. 12_Supplement (June 15, 2022): 413. http://dx.doi.org/10.1158/1538-7445.am2022-413.
Full textChuang, E., D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall. "Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues." Molecular and Cellular Biology 14, no. 8 (August 1994): 5318–25. http://dx.doi.org/10.1128/mcb.14.8.5318-5325.1994.
Full textChuang, E., D. Barnard, L. Hettich, X. F. Zhang, J. Avruch, and M. S. Marshall. "Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues." Molecular and Cellular Biology 14, no. 8 (August 1994): 5318–25. http://dx.doi.org/10.1128/mcb.14.8.5318.
Full textWeber, Shannon, Nicole Brossier, Amanda Prechtl, Stephanie Brosius, Stephen Barnes, Landon Wilson, and Steven Carroll. "CSIG-02. R-RAS SUBFAMILY PROTEINS ELICIT DISTINCT PHYSIOLOGIC EFFECTS AND PHOSPHOPROTEOME ALTERATIONS IN NEUROFIBROMIN-NULL MPNST CELLS." Neuro-Oncology 22, Supplement_2 (November 2020): ii27—ii28. http://dx.doi.org/10.1093/neuonc/noaa215.114.
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