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Books on the topic 'Range advance'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Hao, Chengpeng, Danilo Orlando, Jun Liu, and Chaoran Yin. Advances in Adaptive Radar Detection and Range Estimation. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-6399-4.

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2

Advanced high dynamic range imaging: Theory and practice. Natick, Mass: A K Peters, 2011.

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3

International, Conference on Range Management in the Arabian Gulf (1st 1985 Kuwait Kuwait). Advances in range management in arid lands: Proceedings of the First International Conference on Range Management in the Arabian Gulf. London: Kegan Paul International, 1990.

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4

Development, North Atlantic Treaty Organization Advisory Group for Aerospace Research and. Recent advances in long range and long endurance operation of aircraft. Neuilly sur Seine, France: AGARD, 1993.

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5

North Atlantic Treaty Organization. Advisory Group for Aerospace Research and Development. Recent advances in long range and long endurance operation of aircraft. Neuilly sur Seine, France: AGARD, 1993.

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6

K, Lu Frank, and Marren Dan E, eds. Advanced hypersonic test facilities. Reston, Va: American Institute of Aeronautics and Astronautics, 2002.

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7

Pye, John M. Advances in threat assessment and their application to forest and rangeland management. Portland, OR: U.S. Dept. of Agriculture, Forest Service, Pacific Northwest Research Station, 2010.

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8

Broomhall, Susan, ed. Women and Power at the French Court, 1483-1563. NL Amsterdam: Amsterdam University Press, 2018. http://dx.doi.org/10.5117/9789462983427.

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Women and Power at the French Court, 1483—1563 explores the ways in which a range of women “ as consorts, regents, mistresses, factional power players, attendants at court, or as objects of courtly patronage “ wielded power in order to advance individual, familial, and factional agendas at the early sixteenth-century French court. Spring-boarding from the burgeoning scholarship of gender, the political, and power in early modern Europe, the collection provides a perspective from the French court, from the reigns of Charles VIII to Henri II, a time when the French court was a renowned center of culture and at which women played important roles. Crossdisciplinary in its perspectives, these essays by historians, art and literary scholars investigate the dynamic operations of gendered power in political acts, recognized status as queens and regents, ritualized behaviors such as gift-giving, educational coteries, and through social networking, literary and artistic patronage, female authorship, and epistolary strategies.

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9

Chernyavskiy, Aleksandr. General theory of law in connection with the axiology of values. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1371623.

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The monograph presents the author's view on the legal quality of law from the point of view of the theory of law as the norms of coordinating interests about values. The author gives an assessment of the norms of law as the norms of differentiation and coordination of relations regarding values. The article analyzes what is the driving principle of law: the convergence of state values and human values. The author believes that any attempts to assign priority to certain values without taking into account their real correlation in society are doomed to failure in advance. The attitude of a person to the law is the defining embodiment of legal values as the socio-cultural basis of law. The law regulates the procedure for the realization of interests in relation to values. For a wide range of readers interested in legal issues. It will be useful for students, postgraduates and teachers of law schools.

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10

Mayer, Kenneth R. The development of the advanced medium-range air-to-air missile: A case study of risk and reward in weapon system acquisition. Santa Monica, CA: Rand, 1993.

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11

NATO Advanced Research Workshop on the Long-Range Atmospheric Transport of Natural and Contaminant Substances from Continent to Ocean and Continent to Continent (1988 Saint George, Bermuda Islands). The long-range atmospheric transport of natural and contaminant substances: [proceedings of the NATO Advanced Research Workshop on the Long-Range Atmospheric Transport of Natural and Contaminant Substances from Continent to Ocean and Continent to Continent, St. Georges, Bermuda, January 10-17, 1988]. Dordrecht: Kluwer Academic Publishers, 1990.

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12

Beer, Louis W. Distribution and growth of advance Douglas-fir regeneration in commercially thinned stands in the Oregon Coast Range. 1998.

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13

Thomas, Keri, Ben Lobo, and Karen Detering, eds. Advance Care Planning in End of Life Care. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198802136.001.0001.

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Advance Care Planning (ACP) is an essential part of quality end of life care in the UK and in most developed countries, enabling more people to live well and die well as they would choose. In the context of the ageing population, with increasing possibilities for medical interventions, ACP is an crucial consideration, with important implications for the individual person and their family and for our wider population. This book takes a comprehensive look at the subject, helps readers explore a wide range of issues and practicalities in providing ACP; frames the purpose, process, and outcomes; provides updates on national and international research, policy, and practice and includes contributions from experts from around the world. Death will affect us all; it is the one certainty in life. Yet the subject of death remains something of a taboo, we rarely discuss what our preferences would be at end of life, what we would want, where we would want to be cared for, not even with loved ones.

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14

Center, Ames Research, ed. Advanced ballistic range technology. Moffett Field, Calif: NASA National Aeronautics and Space Administration, Ames Research Center, 1994.

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15

Chalmers, Alan, Francesco Banterle, Kurt Debattista, and Alessandro Artusi. Advanced High Dynamic Range Imaging. CRC Press LLC, 2017.

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16

Chalmers, Alan, Francesco Banterle, Kurt Debattista, and Alessandro Artusi. Advanced High Dynamic Range Imaging. CRC Press LLC, 2017.

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17

Chalmers, Alan, Francesco Banterle, Kurt Debattista, and Alessandro Artusi. Advanced High Dynamic Range Imaging. CRC Press LLC, 2017.

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18

Chalmers, Alan, Francesco Banterle, Kurt Debattista, and Alessandro Artusi. Advanced High Dynamic Range Imaging. CRC Press LLC, 2017.

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19

Advanced High Dynamic Range Imaging. Taylor & Francis Group, 2017.

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20

Chalmers, Alan, Francesco Banterle, Kurt Debattista, and Alessandro Artusi. Advanced High Dynamic Range Imaging. Taylor & Francis Group, 2021.

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21

(Editor), Olafur Arnalds, and Steve Archer (Editor), eds. Rangeland Desertification (ADVANCES IN VEGETATION SCIENCE Volume 19) (Advances in Vegetation Science(discontinued)). Springer, 1999.

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22

Clare, Sarb, and Chris Duncan, eds. Ultrasound for the Generalist. Cambridge University Press, 2021. http://dx.doi.org/10.1017/9781108850476.

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Point of care ultrasound is a critical tool required for assessing all patients, providing rapid answers to clinical questions and facilitating high quality care for patients. This essential guide caters for all generalist clinicians beginning their ultrasound journey and extends to more advanced assessments for those with established ultrasound experience wishing to advance their knowledge and skills. It covers a wide range of ultrasound topics from echocardiography, thoracic and COVID-19 to emerging areas such as palliative care, hospital at home and remote and austere medicine. An extensive collection of colour images, videos and examples of clinical applications will inspire readers to acquire the skills of point of care ultrasound quickly, safely and systematically. The printed code on the inside of the cover provides access to an online version on Cambridge Core. An essential aid for acute clinicians, paramedics, general practitioners as well as remote medical providers, medical educators and students.

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23

Liu, Jun, Danilo Orlando, Chengpeng Hao, and Chaoran Yin. Advances in Adaptive Radar Detection and Range Estimation. Springer Singapore Pte. Limited, 2022.

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24

Zaider, Talia, Shira Hichenberg, and Lauren Latella. Advancing family communication skills in oncology nursing. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198736134.003.0028.

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This chapter presents a new communication skills training initiative designed to advance family-centred care in the inpatient oncology setting. Because of their consistent contact with families, oncology nurses are well-positioned to initiate and model supportive care to the family. Two formats of training are presented: (i) a single-session module for acute care nurses focuses on responding to challenging family interactions at the bedside; (ii) a comprehensive, six-month curriculum for advanced practice nurses focuses on conceptualization and intervention skills, as applied to a range of complex family situations that arise during a patient’s admission. The training presented here teaches nurses to effectively partner with families, assess support needs, facilitate collaborative problem-solving, and transition families to psychosocial resources. Both training efforts were piloted at a large, comprehensive cancer centre. Preliminary data supports the feasibility and perceived relevance of training content, as well as gains in nurses’ confidence working effectively with families.

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25

Ghertner, D. Asher, and Robert W. Lake, eds. Land Fictions. Cornell University Press, 2021. http://dx.doi.org/10.7591/cornell/9781501753732.001.0001.

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This book explores the common storylines, narratives, and tales of social betterment that justify and enact land as commodity. It interrogates global patterns of property formation, the dispossessions property markets enact, and the popular movements to halt the growing waves of evictions and land grabs. This collection brings together original research on urban, rural, and peri-urban India; rapidly urbanizing China and Southeast Asia; resource expropriation in Africa and Latin America; and the neoliberal urban landscapes of North America and Europe. Through a variety of perspectives, the book finds resonances between local stories of land's fictional powers and global visions of landed property's imagined power to automatically create value and advance national development. The book unpacks the dynamics of land commodification across a broad range of political, spatial, and temporal settings, exposing its simultaneously contingent and collective nature. It advances understanding of the politics of land while also contributing to current debates on the intersections of local and global, urban and rural, and general and particular.

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26

Dmowska, Renata, and Barry Saltzman. Advances in Geophysics: Long-Range Persistence in Geophysical Time Series. Elsevier Science & Technology Books, 1999.

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27

Grimm, Stephen R., ed. Making Sense of the World. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190469863.001.0001.

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This collection offers original work on the nature of understanding by a range of distinguished philosophers. Although some of the essays are by scholars well known for their work on understanding, many of the essays bring entirely new figures to the debate. The main purpose of the volume is twofold: (a) to advance debates in epistemology and the philosophy of science, where work on understanding has recently flourished, and (b) to jumpstart new questions and debates about understanding in other areas of philosophy, such as aesthetics, ethics, and the philosophy of religion.

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28

Mathers, Nigel, and Craig Sinclair. Planning ahead in all areas. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198802136.003.0026.

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Advance care planning (ACP) has traditionally been identified as a means by which patients can give anticipatory directions for future medical treatment. However the narrow focus on medical treatments has been criticized by those who argue that ACP should commence early in a life-limiting illness, be an ongoing process, and encompass goals and values in a broad range of domains (e.g. cultural, spiritual, lifestyle, and/or financial). Benefits would include reduced focus on end-of-life care, alignment with person-centred care principles, and greater capacity for incorporating ‘future planning’ discussions into routine care. This approach may be accessible to a broader range of patients, enabling meaningful discussions to commence prior to, or soon after, diagnosis of a life-limiting illness. We discuss the implications of this broad approach to ACP for practitioners, patients, and family caregivers, with reference to relevant case examples.

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29

Smith, Sarah, and Keina Yoshida, eds. Feminist Conversations on Peace. Bristol University Press, 2022. http://dx.doi.org/10.47674/9781529222074.

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EPUB and EPDF available Open Access under CC-BY-NC-ND licence. What is feminist peace? How can we advocate for peace from patriarchy? What do women, globally, advocate for when they use the term 'peace'? This edited collection brings together conversations across borders and boundaries to explore plural, intersectional and interdisciplinary concepts of feminist peace. The book includes contributions from a geographically diverse range of scholars, judges, practitioners and activists, and the chapters cut across themes of movement building and resistance and explore the limits of institutionalized peacebuilding. The chapters deal with a range of issues, such as environmental degradation, militarization, online violence and arms spending. Offering a resource to advance theoretical development and to advocate for policy change, this book transcends traditional approaches to the study of peace and security and embraces diverse voices and perspectives which are absent in both academic and policy spaces.

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30

Chinn, Peggy L. Developing Substance: Mid-Range Theory in Nursing (Advances in Nursing Science). Aspen Pub, 1994.

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31

Evans, Jeff, Sally Ruane, and Humphrey Southall, eds. Data in Society. Policy Press, 2019. http://dx.doi.org/10.1332/policypress/9781447348214.001.0001.

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Statistical data and evidence-based claims are increasingly central to our everyday lives. Critically examining ‘Big Data’, this book charts the recent explosion in sources of data, including those precipitated by global developments and technological change. It sets out changes and controversies related to data harvesting and construction, dissemination and data analytics by a range of private, governmental and social organisations in multiple settings. Analysing the power of data to shape political debate, the presentation of ideas to us by the media, and issues surrounding data ownership and access, the authors suggest how data can be used to uncover injustices and to advance social progress

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32

Hui, David, Akhila Reddy, and Eduardo Bruera. 50 Studies Every Palliative Care Doctor Should Know. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190658618.001.0001.

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50 Palliative Care Studies Every Doctor Should Know provides a succinct summary and critical appraisal of 50 landmark studies that have defined the practice of palliative care. Carefully handpicked by the editors based on their scientific impact, these studies provide important insights into the evolution of this rapidly growing discipline. These articles cover a wide range of domains across interdisciplinary palliative care, such as pain and symptom management, psychosocial issues, spiritual care, caregiver distress, communication, advance care planning, prognostication, decision making, and end-of-life care. The principles of palliative care discussed in this book may be applicable throughout the trajectory of multiple life-limiting diseases.

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33

Carrigan, Chris, and Cary Coglianese. George J. Stigler, “The Theory of Economic Regulation”. Edited by Martin Lodge, Edward C. Page, and Steven J. Balla. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199646135.013.41.

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This chapter discusses George Stigler’s “The Theory of Economic Regulation,” a stinging analysis of regulation from a political economy perspective. Published in 1971, Stigler’s paper challenged the idea that regulation is designed and operated primarily for the benefit of business, rather than solely to advance the overall public interest by correcting market failures. By offering a serious take on regulatory capture, “The Theory of Economic Regulation” changed the way economists analyze government regulation while exerting tremendous influence on a variety of disciplines such as public policy. Stigler’s chapter also sparked extensive research on business–government relations across a wide range of industries, from airlines and mining to banking and manufacturing.

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34

(Editor), Renata Dmowska, and Barry Saltzman (Editor), eds. Long-Range Persistence in Geophysical Time Series, Volume 40 (Advances in Geophysics). Academic Press, 1999.

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35

(Editor), Renata Dmowska, and Barry Saltzman (Editor), eds. Long-Range Persistence in Geophysical Time Series, Volume 40 (Advances in Geophysics). Academic Press, 1999.

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36

Halwagy, Riad. Advances in Range Management in Arid Lands: Proceedings of the First International Conference on Range Management in the Arabian Gulf. Kegan Paul International Ltd., 1990.

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37

Rodrigo, Olivares-Caminal, Douglas John, Guynn Randall, Kornberg Alan, Paterson Sarah, and Singh Dalvinder. Part II Bank Resolution, 6 Banks in Distress. Oxford University Press, 2016. http://dx.doi.org/10.1093/law/9780198725244.003.0006.

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This chapter looks at the background of the Banking Act 2009 and various other reforms in the UK. While the Banking Act 2009 was originally introduced to deal with banks in distress it has been significantly modified to apply to a range of UK institutions such as building societies, investment firms, and central counterparties and banking groups. The 2009 Act provides the ‘appropriate regulator’, and the Bank of England as resolution authority provides the tools to deal with a UK institution that is experiencing financial difficulties. The chapter also looks at the recovery and resolution plans that are now an integral part of the decision-making process for the authorities as they decide how best to prepare an institution in advance of crisis.

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38

Dixon, Josie. Person-centred care. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198802136.003.0004.

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Person-centred care emphasizes compassion and dignity, is well-coordinated and respects individual needs and preferences. Advance care planning helps to facilitate person-centred care by allowing people to have a say in decisions about their end of life care, as well as being associated with a range of person-centred outcomes. Economic evaluations of ACP have tended to focus on hospital cost savings. However, such studies are too limited and more comprehensive economic evaluations are needed, taking into account not just financial costs and savings, but also wider person-centred benefits. ACP has, as its primary purpose, the aim of making a person’s voice heard, even when that person can no longer speak for themselves directly. Terminology and legal frameworks vary.

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39

Ward, Paul, Jan Maarten Schraagen, Julie Gore, and Emilie M. Roth, eds. The Oxford Handbook of Expertise. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198795872.001.0001.

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The purpose of this Handbook is to provide a comprehensive picture of the field of Expertise Studies. We offer both traditional and contemporary perspectives, and importantly, a multidiscipline-multimethod view of the science and engineering research on expertise. We present different perspectives, theories, and methods of conducting expertise research, all of which have had an impact in helping us better understanding expertise across a broad range of domains. The Handbook also describes how researchers and practitioners have addressed practical problems and societal challenges. We have sought to demonstrate the heterogeneity of approaches and conceptions of expertise, to place current views of expertise in context, to show how these views can be used to address current issues, and to examine ways to advance the study of expertise.

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40

Fighter Basing Options to Improve Access to Advanced Training Ranges. RAND Corporation, 2021. http://dx.doi.org/10.7249/rra169-1.

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41

Mills, Patrick, John A. Ausink, Anu Narayanan, Bradley DeBlois, and Anna Jean Wirth. Fighter Basing Options to Improve Access to Advanced Training Ranges. RAND Corporation, The, 2021.

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42

Sandberg, Jörgen, Linda Rouleau, Ann Langley, and Haridimos Tsoukas. Introduction. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198806639.003.0001.

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Skillful performance has become one of the most perennial and critical questions within management and organization studies (MOS). This introductory chapter discusses how skillful performance has been conceptualized and investigated in three main interrelated research areas within MOS, namely strategic management, organizational learning and knowledge management, and human resource management. It critically scrutinizes these bodies of literatures, showing that while they have generated an abundance of knowledge about what characterizes the properties of the capabilities, knowledge, competence, and expertise related to skillful performance, they have considerably less to say about how they are enacted in skillful performance. As a way forward, the chapter introduces a range of process-based approaches to advance our understanding of how capabilities, knowledge, competence, and expertise are enacted in the skillful performance of individuals, groups, and organizations.

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43

Mannava V.K. Sivakumar (Editor) and James Hansen (Editor), eds. Climate Prediction and Agriculture: Advances and Challenges. Springer, 2007.

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44

Koppell, Carla, ed. Untapped Power. Oxford University Press, 2022. http://dx.doi.org/10.1093/oso/9780197611609.001.0001.

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Untapped Power, brings together scholars, policy makers, researchers, and activists to provide a comprehensive overview for understanding why an enduring global commitment to diversity and inclusion is essential, and how to advance that agenda in practical terms. The book presents diversity trends and movements for inclusion; outlines specific strategies and approaches for promoting inclusion throughout peacebuilding and development processes; and discusses the priorities for advancing the agenda through research, advocacy, financial investments, and programming. The book overviews the business case for inclusion by comprehensively detailing the dividends for economic development, social cohesion, conflict resolution and peacebuilding that accrue from leveraging diversity. Further, the volume details the consequences of exclusionary approaches to international affairs, specifically the connections to intractable conflict, militancy, terrorism, and enduring poverty and under-development. Expert authors also reflect on a range of movements for inclusion, including those around gender equality and women, indigenous communities, LGBTQI people, ethnic, racial and religious minorities, and those with disabilities, among others. Chapters discuss strategies for managing and leveraging diversity, advancing inclusion to prevent and resolve violent conflict, and promoting sustainable development. Overall, the book synthesizes theory, research, and analysis to show the necessity of an enduring global commitment to diversity and inclusion, and reveals how to advance that agenda. A guide to one of the most pressing issues in world politics, this book is perfect for teaching about diversity, equity and inclusion. It is also essential reading for those working in global development, conflict resolution, or peace building.

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45

Stewart-Kroeker, Sarah. Introduction. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198804994.003.0001.

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This is an introduction to the key themes of the book as well as to the scholarly context. It includes some notes on the translation of peregrinatio and its range of meanings, including (but not restricted to) pilgrimage. The peregrinatio image’s prominent eschatological cast evokes modern anxieties that run in a couple of directions. One worry is that framing the earthly life in terms of the journey to the heavenly homeland undermines this-worldly love and action, particularly in caring for the neighbor. Another worry is that ordering life to an end determined in advance confines the self’s growth, agency, or identity. The Introduction also frames the reflection on beauty and moral formation in light of contemporary concerns both with Augustine’s thought in particular and more broadly in terms of the possibility of linking beauty and morality after the Enlightenment.

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46

Windsor, Duane. Educating for Responsible Management. Edited by Andrew Crane, Dirk Matten, Abagail McWilliams, Jeremy Moon, and Donald S. Siegel. Oxford University Press, 2009. http://dx.doi.org/10.1093/oxfordhb/9780199211593.003.0022.

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This article reviews theories of management education and current coverage of corporate social responsibility (CSR) concepts in the United States, Europe, and elsewhere. It then examines prospects for responsible management education in the 21st century. It proceeds in four main sections. First, it addresses management education theories. Second, it assesses the state of knowledge concerning responsible management. Third, it examines the state of knowledge concerning education for responsible management. Views range from the impossibility of changing the moral character of adults and the uselessness of responsibility education through the identification of profit incentives for responsibility activities to demands for business schools and corporations to try harder in the wake of recent corporate scandals. Fourth, this article discusses the effect of the Association to Advance Collegiate Schools of Business international accreditation standards on responsibility education. A concluding section summarizes the chief points.

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47

Beaty, Roger E., and Rex E. Jung. Interacting Brain Networks Underlying Creative Cognition and Artistic Performance. Edited by Kalina Christoff and Kieran C. R. Fox. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190464745.013.10.

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Cognitive neuroscience research has begun to address the potential interaction of brain networks supporting creativity by employing new methods in brain network science. Network methods offer a significant advance compared to individual region of interest studies due to their ability to account for the complex and dynamic interactions among discrete brain regions. As this chapter demonstrates, several recent studies have reported a remarkably similar pattern of brain network connectivity across a range of creative tasks and domains. In general, such work suggests that creative thought may involve dynamic interactions, primarily between the default and control networks, providing key insights into the roles of spontaneous and controlled processes in creative cognition. The chapter summarizes this emerging body of research and proposes a framework designed to account for the joint influence of controlled and spontaneous thought processes in creativity.

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48

Pogge, Thomas, and Scott Wisor. Measuring Poverty. Edited by Matthew D. Adler and Marc Fleurbaey. Oxford University Press, 2016. http://dx.doi.org/10.1093/oxfordhb/9780199325818.013.20.

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This chapter documents a participatory approach to developing a new, gender-sensitive measure of deprivation that improves upon existing measures of poverty and gender equity. Over three years, across 18 sites in Angola, Fiji, Indonesia, Malawi, Mozambique, and the Philippines, men and women in poor communities engaged in a range of qualitative discussions and quantitative evaluation exercises to help develop the Individual Deprivation Measure. The IDM tracks deprivation in 15 dimensions, uses interval scales within dimensions, and can easily be administered in most impoverished areas. It represents a significant advance in multidimensional measurement by focusing on individuals rather than households, by covering all important dimensions of poverty, by being gender-sensitive in the selection and coding of dimensions, and by being appropriately sensitive to the depth of deprivation. The IDM demonstrates the possibility of establishing objective tools of social valuation through a process of public reason.

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49

Keck, Thomas M. The Relationship between Courts and Legislatures. Edited by Lee Epstein and Stefanie A. Lindquist. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199579891.013.27.

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This chapter surveys four overlapping contexts in which scholars have examined institutional interactions between U.S. courts and legislatures. First, some have sought to explain when and why judges exercise the power of judicial review by invalidating democratically enacted statutes. Second, “regime politics” scholars have examined the political foundations of judicial power over time, emphasizing that courts have developed, retained, and expanded the authority to alter policy outcomes only because (and to the extent that) governing legislative coalitions have supported these developments. Third, some scholars have examined the range of legislative responses to assertions of judicial power, emphasizing that the judicial interpretation or even invalidation of a legislative policy is often far from the final word on the policy conflict in question. Fourth, some scholars have advocated an “interbranch perspective” on the policy process. This fourth approach has significant potential to advance existing understandings of the relationship between courts and legislatures.

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50

Nestler, Eric J. New Approaches for Treating Depression. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0030.

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Several obstacles have impeded the introduction of new antidepressant medications over the past six decades. These obstacles include our still rudimentary knowledge of the biological basis of depression, as well as difficulties in evaluating the therapeutic efficacy of new putative antidepressant mechanisms in pathophysiologically distinct subtypes of the syndrome. Despite these obstacles, several tangible steps can be taken to advance depression treatment moving forward. The field needs to continue to take advantage of serendipitous discoveries in humans, such as the demonstration of rapid antidepressant effects of ketamine. Re-establishing experimental pharmacology in humans, to make it possible to establish the actions of new mechanisms in people, is essential, combined with the judicious use of a growing range of chronic stress models in animals. We anticipate that, with these approaches, the field can at long last breakthrough the logjam of discovery and introduce new treatments for depression over the next decade.

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