Relevant bibliographies by topics / Randomised controlled trial

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Randomised controlled trial'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

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Journal articles on the topic "Randomised controlled trial"

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Doully, Dr Kumari, Dr Dewesh Kumar, and Dr S. B. Sinha Dr. S. B Sinha. "A Non randomised controlled trial of Eprosartan." Indian Journal of Applied Research 4, no. 6 (October 1, 2011): 361–63. http://dx.doi.org/10.15373/2249555x/june2014/112.

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Ubbink, Dirk, and Hester Vermeulen. "Randomised controlled trial." TVZ - Verpleegkunde in praktijk en wetenschap 132, no. 3 (June 2022): 52–53. http://dx.doi.org/10.1007/s41184-022-1120-2.

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de Jong, Jip, and Nynke van Dijk. "Randomised controlled trial." Huisarts en wetenschap 56, no. 8 (August 2013): 391. http://dx.doi.org/10.1007/s12445-013-0208-x.

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Relton, C., D. Torgerson, A. O'Cathain, and J. Nicholl. "Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design." BMJ 340, mar19 1 (March 19, 2010): c1066. http://dx.doi.org/10.1136/bmj.c1066.

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Yeole, Ujwal Lakshman. "Effectiveness of Proprioceptive Neuromuscular Facilitation on Spasticity in Hemiplegia: Randomised Controlled Trial." Journal of Medical Science And clinical Research 05, no. 01 (January 13, 2017): 15567–72. http://dx.doi.org/10.18535/jmscr/v5i1.61.

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CRAFT, A. W., and T. EDITORS. "The first randomised controlled trial." Archives of Disease in Childhood 79, no. 5 (November 1, 1998): 410. http://dx.doi.org/10.1136/adc.79.5.410.

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Howard, Louise M., Margaret Heslin, Morven Leese, Paul McCrone, Christopher Rice, Manuela Jarrett, Terry Spokes, Peter Huxley, and Graham Thornicroft. "Supported employment: randomised controlled trial." British Journal of Psychiatry 196, no. 5 (May 2010): 404–11. http://dx.doi.org/10.1192/bjp.bp.108.061465.

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BackgroundThere is evidence from North American trials that supported employment using the individual placement and support (IPS) model is effective in helping individuals with severe mental illness gain competitive employment. There have been few trials in other parts of the world.AimsTo investigate the effectiveness and cost-effectiveness of IPS in the UK.MethodIndividuals with severe mental illness in South London were randomised to IPS or local traditional vocational services (treatment as usual) (ISRCTN96677673).ResultsTwo hundred and nineteen participants were randomised, and 90% assessed 1 year later. There were no significant differences between the treatment as usual and intervention groups in obtaining competitive employment (13% in the intervention group and 7% in controls; risk ratio 1.35, 95% CI 0.95–1.93, P = 0.15), nor in secondary outcomes.ConclusionsThere was no evidence that IPS was of significant benefit in achieving competitive employment for individuals in South London at 1-year follow-up, which may reflect suboptimal implementation. Implementation of IPS can be challenging in the UK context where IPS is not structurally integrated with mental health services, and economic disincentives may lead to lower levels of motivation in individuals with severe mental illness and psychiatric professionals.
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Hotopf, Matthew. "The pragmatic randomised controlled trial." Advances in Psychiatric Treatment 8, no. 5 (September 2002): 326–33. http://dx.doi.org/10.1192/apt.8.5.326.

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In recent years there has been much debate regarding the evaluation of treatments in medicine. The evidence-based medicine (EBM) movement has formed partly out of the realisation that clinical practice is often poorly informed by the best available evidence, and that many widely used treatments are either completely untested, or tested and proven to be ineffective or even harmful. EBM has been characterised as a stick by which policy-makers and academics beat clinicians (Williams & Garner, 2002). However, another side to EBM has been the realisation that research performed to test new treatments has often been of poor quality, or has asked the wrong questions (Hotopf et al, 1997; Thornley & Adams, 1998; Barbui & Hotopf, 2001). We have previously argued that clinicians could justifiably criticise the research establishment for failing to provide answers to relevant clinical problems of everyday practice (Hotopf et al, 1999).
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Whiteside, Katie, Lydia Flett, Alex Mitchell, Caroline Fairhurst, Sarah Cockayne, Sara Rodgers, and David J. Torgerson. "Using pens as an incentive for trial recruitment of older adults: An embedded randomised controlled trial." F1000Research 8 (March 21, 2019): 315. http://dx.doi.org/10.12688/f1000research.18300.1.

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Background: Meeting recruitment targets for randomised controlled trials is challenging. This trial evaluated the effectiveness of including a pen within the trial invitation pack on the recruitment of older adults into a randomised controlled trial. Methods: This trial was embedded within the Occupational Therapist Intervention Study, a falls-prevention randomised controlled trial. Potential participants (n = 1862), who were posted an invitation pack from two General Practitioner practices, were randomised to either not receive a pen (n = 1295) or receive a pen (n = 648) with their invitation pack, using a 2:1 ratio. The primary outcome was the likelihood of being randomised, and therefore fully recruited, to the host trial. To be randomised to the host trial, participants had to: return a consent form and screening form; be eligible on their screening form; and return a baseline questionnaire and a monthly falls calendar. Secondary outcomes were: the likelihood of returning (and time to return) a screening form; being eligible for the host trial; and remaining in the trial for at least 3 months. Results: The likelihood of being randomised to the host trial did not differ between the pen group (4.5%) and no pen group (4.3%; odds ratio 1.04; 95% confidence interval: 0.65 to 1.67; p = 0.86). There were marginal differences in secondary outcomes in favour of the pen group, particularly in screening form return rates, though these differences were not statistically significant. Conclusion: Pens may not be an effective incentive for the recruitment of older adults into randomised controlled trials, though future trials are required. Registration: ISRCTN22202133; SWAT 37.
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Pande, Anandlkumar, and Sagar Bandiste. "Effects of Intravenous Dexmedetomidine on Bupivacaine Spinal Anaesthesia: A Placebo Controlled Randomised Trial." Indian Journal of Anesthesia and Analgesia 4, no. 2 (Part-2) (2017): 369–73. http://dx.doi.org/10.21088/ijaa.2349.8471.42(pt-ii)17.1.

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Dissertations / Theses on the topic "Randomised controlled trial"

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Newbury, Jonathan. "75+ health assessments : a randomised controlled trial." Title page, contents and abstract only, 2001. http://thesis.library.adelaide.edu.au/adt-SUA/public/adt-SUA20011123.113220.

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Includes bibliographical references. Electronic publication; full text available in PDF format; abstract in HTML format. The aims of this study were to compare preventative care for the elderly, known as 75+ Health Assessment (75+ HA), with usual care in a randomised controlled trial in the elderly living independently in their own home. Further, the study aims to evaluate whether there are measurable differences in defined primary and secondary outcome measures between the control and intervention groups. The results of the trial are discussed and recommendations made. Electronic reproduction.[Australia] :Australian Digital Theses Program,2001. 283, [15] leaves : ill. ; 30 cm.
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Caldwell, Patrina Ha Yuen. "The Recruitment of Children to Randomised Controlled Trials." University of Sydney. Paediatrics and Child Health, 2003. http://hdl.handle.net/2123/579.

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Abstract Background The randomised-controlled trial (RCT) provides the best evidence for evaluating treatment effects and is accepted as a gold standard for clinical and regulatory decision making (1;2). One of the major challenges to the conduct of RCTs is the recruitment of adequate numbers of participants. Inadequate numbers reduce the power of a study to detect statistically significant treatment effects, and may cause delays, increased costs and failure to complete trials. The need for clinical trials in children has been increasingly recognised by the scientific community, resulting in increased demands for the inclusion of children in trials. For several reasons, recruiting children to trials is more challenging than recruiting adults, as consent issues are more difficult because parents make decisions about trial participation on behalf of their child. Despite general professional and community support for paediatric clinical trials, parents and paediatricians express reluctance when their own child or patient is asked to participate. Although researchers working with children commonly experience difficulty with recruiting children to RCTs, little is known about this very important subject. The method by which potential participants are approached for trial participation, the influence of their health care provider and the attitude of potential participants (or their parents, in the case of children), are critical to the understanding of the decision making process for trial participation. This thesis is one of the first major attempts to explore the issues surrounding the recruitment of children to RCTs, and is divided into four studies which address these issues. Methods Recruitment strategies used to encourage participation in randomised controlled trials (systematic review) Eligible experimental and observational studies comparing methods of recruiting participants for RCTs were identified after a comprehensive search of Medline, Embase, the Cochrane Library and reference lists. Independent data extractions were completed by two reviewers who assessed the studies for eligibility and methodological quality. Outcome measures were consent rates, proportion enrolled by each method and cost of recruitment per participant. Summary estimators of effects were calculated using a random effects model and expressed as relative risk with 95% confidence intervals. Heterogeneity was analysed using the Q statistic. Paediatricians� attitudes to children�s participation in randomised controlled trials (focus group research) Qualitative analysis of focus group discussions involving 16 paediatricians and 5 trainees from a paediatric teaching hospital in Sydney was undertaken. Doctors varied in occupation, experience, research activity, age, gender, ethnicity and parenthood experience. A professional facilitator conducted the semi-structured group discussions. Recruitment ceased when informational redundancy was reached, after 4 focus groups involving 21 participants. The transcribed audiotapes were analysed by theme linkage using the constant comparative method. Australian paediatricians� and adult physicians� attitudes to randomised controlled trials (survey) A 44-item questionnaire was sent to 250 paediatricians and 250 adult physicians randomly selected from the membership list of the Royal Australasian College of Physicians. Questions assessing doctors� treatment philosophies and attitudes to trials were compared with demographic and practice variables. Parents� attitudes to children�s participation in randomised controlled trials (focus group research) Qualitative analysis of focus group discussions involving 33 parents from 5 different settings (representing parents of children with a life threatening, chronic or acute illness, with experience in trials and of healthy children) was undertaken. Parents varied in age, gender, ethnicity, level of education, research experience and their child�s health status. The transcribed discussions were analysed by theme linkage using the constant comparative method. Results Recruitment strategies used to encourage participation in randomised controlled trials (systematic review) Fifty papers were included (out of 8602 titles and abstracts searched) which described 8 RCTs, 2 quasi RCTs, 13 prospective cohort studies, 30 retrospective cohort studies and 2 before-after studies. These studies assessed how over 4 million people were approached for RCT participation using 87 different recruitment strategies, with 103,406 people enrolling in RCTs. Health care provider (HCP) referrals had the highest participant consent rates at the time of exposure to trial information (HCP referral versus target mailing: relative risk (RR) 1.84 (95% confidence interval (95%CI) 1.08, 3.13)). They also had the highest consent rates when potential participants respond to the recruitment material by further enquiry about the trial (HCP referral versus community presentation: RR 1.37 (1.06; 1.78); HCP referral versus worksite approach: RR 25.20 (20.19, 31.45); HCP referral versus general community approach: RR 2.53 (0.46, 14.05); HCP referral versus mailing: RR 3.29 (1.26, 8.60); HCP referral versus media: RR 2.66 (1.31, 5.41)). However, by the time potential participants attend eligibility assessment for trial participation, no difference in consent rates could be distinguished by method of recruitment. Higher proportions of study participants were recruited by methods that exposed larger numbers of potential candidates to trial information (despite their lower consent rates). The stated recruitment cost ranged from US$0 to $1108 per participant, with mailing being the most cost-effective method and community methods (such as community presentations, pamphlets and posters displayed at community sites) the least effective. Paediatricians� attitudes to children�s participation in randomised controlled trials (focus group research) From the focus group discussions, paediatricians thought parents balanced perceived gains and risks when deciding about trial participation. They also believed the child�s condition and parents� health beliefs and personal attributes influenced parents� decisions. Other factors thought to be important by paediatricians were the doctors� beliefs and their relationship with the investigators. Paediatricians perceived gains for trial participation including professional benefits for themselves, improved patient care, convenience for the families and themselves and scientific advancement. Perceived risks included inconvenience, inadequate resources and potential harms to the patient and the doctor-patient relationship. Paediatricians with previous research experience were most knowledgeable about RCTs and perceived greatest gains from trial participation. Paediatricians� personal treatment preferences hindered trial support. Australian paediatricians� and adult physicians� attitudes to randomised controlled trials (survey) Response rate from the paediatricians� and adult physicians� survey was 60% (300/500). Australian paediatricians and adult physicians are very similar in their treatment philosophies, and are clinician-oriented rather than research-oriented in their attitudes, with primary allegiance to their patients and preference for selecting treatment rather than referring for trial participation in the face of treatment uncertainty. Professional activities are clinically focused, with limited time assigned for research. Australian doctors perceive little reward for trial participation and claim that the opinions of referring doctors regarding RCTs does not influence them. Predictors of favourable attitudes to trial participation from the survey were time allocation for research, a history of referring patients to trials in the past and younger age (all p values less than 0.0001). Parents� attitudes to children�s participation in randomised controlled trials (focus group research) When parents were interviewed, they acknowledged balancing risks and benefits when deciding about trial participation for their child. Perceived benefits include the offer of hope, better care of their child, the opportunity to access new treatments, healthcare professionals and health information, meeting others in similar circumstances and helping others. Perceived risks include potential side effects, being randomised to ineffective treatments and the inconvenience of participation. The decision for trial participation is also influenced by parental factors (parents� knowledge, beliefs and emotional response), child factors (the child�s health status and preference about participation), trial factors (the use of placebos and the uncertainties of research) and doctor factors (doctor�s recommendations and communication of trial information). Conclusions There are many challenges to the successful conduct of RCTs. Ways of addressing these include: using effective methods of recruiting potential study participants (such as mailing of recruitment material to potential participants) and abandoning ineffective strategies (such as community methods): fostering greater willingness for trial participation by addressing parents� and paediatricians� concerns including enhancing communication between researchers, paediatricians and parents, and improving the gains-hazard balance (by increasing incentives while decreasing inconveniences); and reforming in the health care system to raise the priority placed on clinical research by restructuring clinical research in a clinically predominant workplace and with a clinically predominant workforce. The findings from this study have implications for researchers planning RCTs for children in the future. Careful consideration of the above will enhance RCTs participation for children improving efficiency, lowering costs and ultimately improving the future health care of children.
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Finnegan, Olwyn Ava. "Facilitating cardiac rehabilitation behaviours : a randomised controlled trial." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410935.

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Coskinas, Xanthi. "Changes to design aspects of ongoing randomised controlled trials." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29452.

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Unplanned changes to the research plan of a randomised controlled trial (RCT) may be a necessary response to unforeseen circumstances. Such changes can help ensure the value and relevance of a trial, but also have the potential to introduce a bias if performed inappropriately. This thesis addresses three broad aims. The first was to highlight the methodological implications of approaches to making various unplanned changes through a series of simulation studies. The second was to estimate the prevalence of such changes to a contemporary sample of published RCTs registered with the Australian New Zealand Clinical Trial Registry (ANZCTR). The third was to assess, and extend as applicable, recommendations for ensuring such changes are performed appropriately and are well documented. The simulation studies were performed using data from a large RCT of statin therapy for secondary prevention. The first of these demonstrated how unplanned changes (to various aspects of the design such as the primary endpoint) risks introducing a bias if undertaken with knowledge of treatment allocation, but not if made without knowledge of treatment allocation. The second investigated strategies for reacting to an observed imbalance on baseline prognostic factors in an RCT. It demonstrated that: continuing with original plans of unadjusted analyses, provided valid p-values irrespective of the direction of the prognostic imbalance, and any decisions informed by knowledge of the direction of the prognostic covariate imbalance were prone to bias. The third simulation study investigated strategies for reacting to a lower-than-expected event rate. It showed that switching to an expanded composite endpoint in response to a low pooled event rate does not inflate the type 1 error rate (and is likely to improve the statistical power, provided the expanded composite is sound). A sample of 181 RCTs that were registered with the ANZCTR and had published a primary result paper were assessed for changes to their research plans, and whether these changes were legitimate or not (that is, made with or without knowledge of treatment allocation). A full audit was conducted on trials with accessible protocols (N=124) and a limited central review on trials without accessible protocols (N=57). The primary results publication was cross-checked with the protocol documents across six methodological aspects for the full audit, and trialists were contacted to resolve queries as necessary. The publication was checked against the registry record for the limited central review, over a subset of three methodological aspects. A key finding of this study was that it was often not possible to reliably assess whether changes had been made or whether changes were made in a blinded manner, based on review of documentation alone. After clarification was sought from the participating trialists, changes were found to be relatively common but typically made in a blinded manner. Improvements to the way unplanned changes to RCT research plans are documented are needed. A set of recommendations to supplement existing guidelines relating to the documentation of RCT research plans was developed. One key recommendation was that trialists should adopt and implement the principles of the recently developed CONSERVE 2021 Statement to appropriately perform and document substantive changes. A second was that strategies that oblige trialists to upload full protocols (and protocol amendments) to clinical trial registries warrant further investigation and further consideration should be given to including all key methodological aspects in registry records. The work undertaken provides valuable guidance for trialists (and stakeholders) on how to make and document a methodologically justifiable change to a planned RCT design/analysis and highlights the circumstances under which a change can lead to bias. This is important for ensuring that methodically unsound changes to RCTs are recognised and avoided, and that RCTs that have undergone methodically sound changes are not incorrectly dismissed as potentially biased.
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Barkun, Jeffrey S. "A randomised controlled trial comparing laparoscopic to mini cholecystectomy /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68154.

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To better define the differences between laparoscopic (LC) and mini cholecystectomy (MC) in treating cholelithiasis, we conducted a randomized controlled trial with 70 patients (LC:38, MC:32).
Both groups were comparable at baseline. The median length of post-operative hospital stay and time to full diet were significantly shorter in LC than MC (p $<$ 0.005 for both). Mean duration of convalescence was 11.9 ($ pm$9.1) days for LC and 20.2 ($ pm$16.5) days for MC (p = 0.04). Kaplan-Meier survival analysis confirmed these results. Using Cox's proportional hazards model, duration of convalescence was only found to be associated with the type of cholecystectomy performed. Three quality of life scores showed that LC patients improved more quickly than MC patients after cholecystectomy.
Surgeons underestimated convalescence on average by 25% (p $<$ 0.01) when compared to nurses' measurements.
In conclusion, even though recovery after MC was shorter than generally anticipated, time to recovery from LC was still shorter and more predictable than MC.
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Schroer, Sylvia. "Developing a randomised controlled trial of acupuncture for depression." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538622.

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Woodward, Joanne Lois. "The challenge of conducting a waterbirth randomised controlled trial." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3392/.

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Waterbirths have been available in the United Kingdom as a method of pain relief for childbirth for over two decades but the neonatal safety of birth in water remains unevaluated. Opponents of a waterbirth randomised controlled trial state randomisation would undermine women’s childbirth experience. In addition, little is known about midwives’ attitudes to waterbirths. This thesis addresses some of the lack of evidence by reporting the findings of two studies which had three aims: to investigate the feasibility of a waterbirth RCT to assess the effects of a waterbirth on the neonate, to explore women’s thoughts about participation and whether randomisation affects women’s satisfaction with their childbirth experience and to assess midwives’ attitudes to waterbirths. The first study involved a RCT with a ‘preference arm’. Eighty women were recruited: 60 in the RCT and 20 in the ‘preference arm’. Women were asked to complete questionnaires to assess their expectations for, and satisfaction with, their childbirth experience: at recruitment, after the birth and 6 weeks after the birth. Women in the randomised arm indicated willingness to partake but questioned midwives’ commitment to offering waterbirths. A Q Methodology study was undertaken to identify factors which influence midwives’ (n=31) attitudes towards waterbirths. Four factors were identified: Motivation, Risk Assessment, Confidence, Safety. Conclusion: It is feasible to organise a larger RCT to assess neonatal safety and women would be supportive. Strategies would be required to ensure midwives are confident and supportive of the waterbirth service.
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Featherstone, Katie. "Patient perspectives of participation in a randomised controlled trial." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/06229618-6e8d-4764-8c7a-1f0c0d0af307.

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Dakin, Helen A. "Economic evaluation of factorial randomised controlled trials." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:77eda1f6-dd8c-439a-8871-75fd57a4c7f5.

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Factorial randomised controlled trials (RCTs) evaluate two or more interventions simultaneously, enabling assessment of interactions between treatments. This thesis presents literature reviews, methodological reviews, simulation studies and applied case studies that explore methods for assessing cost-effectiveness based on factorial RCTs. My systematic review suggests that factorial RCTs account for around 3% of trial-based economic evaluations, although there is currently no guidance or methodological work indicating the most appropriate methods. Around 40% of published studies assumed no interaction between treatments and many were poorly-reported. Various mechanisms are likely to produce large interactions within economic endpoints such as costs, quality-adjusted life-years (QALYs) and net benefits. Failing to take account of interactions can introduce bias and prevent efficient allocation of healthcare resources. I developed the opportunity cost of ignoring interactions as a measure of the implications of this bias. However, allowing for small, chance interactions is inefficient, potentially leading to over-investment in research if trial-based evaluations are used to inform decisions about subsequent research. Nonetheless, analyses on simulated trial data suggest that the opportunity cost of adopting a treatment that will not maximise health gains from the healthcare budget is minimised by including all interactions regardless of magnitude or statistical significance. Different approaches for conducting economic evaluations of factorial RCTs (including regression techniques, extrapolation using patient-level simulation, and considering different components of net benefit separately) are evaluated within three applied studies, including both full and partial factorials with 2x2 and 2x2x2 designs. I demonstrate that within both trial-based and model-based economic evaluation, efficient allocation of healthcare resources requires consideration of interactions between treatments, and joint decisions about interacting treatments based on incremental cost-effectiveness evaluated “inside-the-table” on a natural scale. I make recommendations for the design, analysis and reporting of factorial trial-based economic evaluations based on the results of this thesis.
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Saltvedt, Sissel. "Prenatal diagnosis in routine antenatal care : a randomised controlled trial /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-549-6/.

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Books on the topic "Randomised controlled trial"

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Drury, Valerie Mary. Cognitive therapy and recovery from acute psychosis: A randomised controlled trial. Birmingham: University of Birmingham, 1999.

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Jane, Morrell C., and National Co-ordinating Centre for HTA (Great Britain), eds. Costs and benefits of community postnatal support workers: A randomised controlled trial. Alton: Core Research on behalf of the NCCHTA, 2000.

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J, Morrell C., and National Co-ordinating Centre for HTA (Great Britain), eds. Costs and benefits of community postnatal support workers: A randomised controlled trial. Alton: NCCHTA, 2000.

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J, Turner, and National Co-ordinating Centre for HTA (Great Britain), eds. A Randomised controlled trial of prehospital intravenous fluid replacement therapy in serious trauma. Alton: Core Research on behalf of the NCCHTA, 2000.

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J, Vickers A., and National Co-ordinating Centre for HTA (Great Britain), eds. Acupuncture of chronic headache disorders in primary care: Randomised controlled trial and economic analysis. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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C, Iglesias, and National Co-ordinating Centre for HTA (Great Britain), eds. VenUS 1: A randomised controlled trial of two types of bandage for treating venous leg ulcers. Tunbridge Wells: Gray Publishing on behalf of NCCHTA, 2004.

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N, Caine, National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. A randomised controlled crossover trial of nurse practitioner versus doctor-led outpatient care in a bronchiectasis clinic. Southampton: NCCHTA, 2002.

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S, Simpson, and National Co-ordinating Centre for HTA (Great Britain), eds. A Randomised controlled trial to evaluate the effectiveness and cost-effectiveness of counselling patients with chronic depression. Southampton: National Coordinating Centre for Health Technology Assessment, 2000.

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G, Zermansky A., National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. Clinical medication review by a pharmacist of patients on repeat prescriptions in general practice: A randomised controlled trial. Alton: Core Research on behalf of the NCCHTA, 2002.

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Group, Family Heart Study, ed. Randomised controlled trial evaluating cardiovascular screening and intervention in general practice: Principal results of British family heart study. [London]: British Medical Journal, 1994.

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Book chapters on the topic "Randomised controlled trial"

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Bulpitt, Christopher J. "Different Trial Designs." In Randomised Controlled Clinical Trials, 57–83. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_5.

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Bulpitt, Christopher J. "Information to be Collected During a Trial." In Randomised Controlled Clinical Trials, 183–98. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_10.

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Bulpitt, Christopher J. "The Objectives of a Randomised Controlled Trial." In Randomised Controlled Clinical Trials, 45–55. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_4.

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Bulpitt, Christopher J. "The Conduct of the Trial — Good Clinical Practice." In Randomised Controlled Clinical Trials, 199–231. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_11.

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Bulpitt, Christopher J. "How Many Subjects are Required For a Trial?" In Randomised Controlled Clinical Trials, 85–112. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4615-6347-1_6.

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Scott, Jan. "A Randomised Controlled Trial of Cognitive Therapy in Bipolar Disorders." In Cognitive Psychotherapy Toward a New Millennium, 285–88. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0567-9_47.

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Boylan, P., D. MacDonald, A. Grant, M. Pereira, and I. Chalmers. "The Dublin Randomised Controlled Trial of Intrapartum Electronic Fetal Heart Rate Monitoring." In Fetal Heart Rate Monitoring, 34–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70358-4_4.

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Evans, Debra. "Let's talk about the characteristics of a quantitative design – the randomised controlled trial." In Making Sense of Evidence-based Practice for Nursing, 50–63. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003156017-8.

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Dey, Paola, Stuart Collins, Sheila Will, and Ciaran B. J. Woodman. "Randomised controlled trial assessing effectiveness of health education leaflets in reducing incidence of sunburn." In Debates and Dilemmas in Promoting Health, 177–80. London: Macmillan Education UK, 1997. http://dx.doi.org/10.1007/978-1-349-25349-4_19.

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Burger, Huibert, Claudi L. H. Bockting, Chantal Beijers, Tjitte Verbeek, A. Dennis Stant, Johan Ormel, Ronald P. Stolk, Peter de Jonge, Mariëlle G. van Pampus, and Judith Meijer. "Pregnancy Outcomes After a Maternity Intervention for Stressful Emotions (PROMISES): A Randomised Controlled Trial." In Perinatal Programming of Neurodevelopment, 443–59. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1372-5_21.

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Conference papers on the topic "Randomised controlled trial"

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Tiedemann, Anne, Juliana Souza Oliveira, Margaret Allman-Farinelli, Adrian Bauman, Kirsten Howard, Richard Lindley, Stephen Lord, et al. "141 Coaching for Healthy AGEing trial – a cluster-randomised controlled trial." In 14th World Conference on Injury Prevention and Safety Promotion (Safety 2022) abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/injuryprev-2022-safety2022.66.

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Marla, S., M. Proctor, L. Romics, K. Ogston, T. Cooke, and S. Stallard. "Day surgery for breast cancer: a pilot randomised controlled trial." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-5090.

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Reiter, Ehud, Roma Robertson, A. Scott Lennox, and Liesl Osman. "Using a randomised controlled clinical trial to evaluate an NLG system." In the 39th Annual Meeting. Morristown, NJ, USA: Association for Computational Linguistics, 2001. http://dx.doi.org/10.3115/1073012.1073069.

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Cook, A. J. C., Robert H. Davies, A. M. Miller, R. Gopal, C. Byrne, P. J. Heath, and S. Cousens. "A Randomised Controlled Trial To Reduce Salmonella Infection In Finisher Pigs." In Second International Symposium on Epidemiology and Control of Salmonella in Pork. Iowa State University, Digital Press, 2003. http://dx.doi.org/10.31274/safepork-180809-483.

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Mantoani, Leandro, Brian Mckinstry, Susan Mcnarry, Susan Mullen, Susan Begg, Privender Saini, Mareike Klee, Rita Priori, William Macnee, and Roberto Rabinovich. "Physical activity enhancing programme (PAEP) in COPD – a randomised controlled trial." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.oa1986.

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Edbrooke, Lara, Sanchia Aranda, Catherine Granger, Christine Mc Donald, Mei Krishnasamy, Linda Mileshkin, Ross Clark, Ian Gordon, Louis Irving, and Linda Denehy. "Home-based rehabilitation in inoperable lung cancer: a randomised controlled trial." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.oa5188.

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Everitt, Prof Hazel, Sabine Landau, Paul Little, Prof Felicity Bishop, Gillian O’Reilly, Alice Sibelli, Rachel Holland, et al. "OWE-028 Actib trial (assessing cognitive behavioural therapy in irritable bowel): a multicentre randomised controlled trial." In British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-bsgabstracts.416.

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Bilton, D., E. Daviskas, A. Jaques, SD Anderson, and B. Charlton. "A Randomised, Placebo-Controlled Trial of Inhaled Mannitol in Patients with Bronchiectasis." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3221.

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Williams, Marie, Catherine Paquet, Paul Cafarella, and Peter Frith. "Randomised controlled trial of pulmonary rehabilitation including cognitive behavioural therapy for breathlessness." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.oa5195.

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Chaplin, Emma, Stacey Hewitt, Lindsay Apps, Kelly Edwards, Chris Brough, Aga Glab, John Bankart, et al. "An interactive web-based pulmonary rehabilitation programme: A randomised controlled feasibility trial." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa2064.

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Reports on the topic "Randomised controlled trial"

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Haylock, Stuart. Brief alcohol intervention to reduce risky drinking in pregnancy: a pilot randomised controlled trial. National Institute for Health Research, May 2021. http://dx.doi.org/10.3310/nihropenres.1115148.1.

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Landon, Tess, and Harald Hochreiter. Randomised controlled trials and other experimental approaches in the Austrian Research Promotion Agency. Fteval - Austrian Platform for Research and Technology Policy Evaluation, April 2022. http://dx.doi.org/10.22163/fteval.2022.554.

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The objective of this paper/presentation is to highlight how experimental approaches, specifically Randomised Controlled Trials (RCTs), can be leveraged to evaluate and measure the impact of new programmes, support programme development and test new services in funding and innovation agencies. RCTs are seen in many facets of public policy, however RCTs as a method for innovation agencies to evaluate new initiatives is relatively new. We present three RCTs implemented in the Austrian Research Promotion Agency (FFG) that have received funding from the European Union’s Horizon 2020 research and innovation programme. The trials are implemented to evaluate the effectiveness of new measures intended to help strengthen R&I in start-ups and SMEs. Through these three examples, we aim to demonstrate the advantages in which RCTs can augment the evaluation of new services as well as challenges that come with implementing RCTs. For one RCT, we will present final results. Two RCTs are ongoing, and we will present the trial design. We also discuss the operational aspects of incorporating experimentation in an innovation agency.
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Conte, Ianina. Randomised, double blind, placebo controlled, crossover trial of the adjuvant properties of Imipramine for the overactive bladder. National Institute for Health Research, May 2021. http://dx.doi.org/10.3310/nihropenres.1115147.1.

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Li, Yibing, Jinming Song, Xuhui Wang, Lin Han, and Bangqi Wu. Acupuncture versus pharmacological resuscitation in treatment of atrial fibrillation in a randomised controlled trial: systemic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, May 2021. http://dx.doi.org/10.37766/inplasy2021.5.0108.

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Walsh, Phoebe. A randomised controlled trial of total resurfacing versus hemi resurfacing in the treatment of primary osteoarthritis of the shoulder. National Institute for Health Research, February 2022. http://dx.doi.org/10.3310/nihropenres.1115180.1.

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Dua, Shelley, Andrew Clark, Monica Ruiz-Garcia, Simon Bond, Stephen Durham, Ian Kimber, Clare Mills, et al. The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomised controlled study. Food Standards Agency, May 2020. http://dx.doi.org/10.46756/sci.fsa.vjv675.

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This was a randomised cross-over trial that investigated whether common extrinsic factors, such as exercise and sleep deprivation can modulate the threshold of responses to allergenic foods in a representative group of adults from the peanut allergic population.
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Conte, Ianina. A pilot randomised controlled single-blind trial of a collagen implant for the prevention of sternal wound infection in cardiac surgery. National Institute for Health Research, January 2022. http://dx.doi.org/10.3310/nihropenres.1115176.1.

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Çalışkan Sarı, Arzu, and Özden Yalçınkaya Alkar. Randomised Controlled Trial of Online Empathy Focused Intercultural Communication Program for Turkish Local Society to Increase Their Social Acceptance Towards Refugees. Peeref, July 2022. http://dx.doi.org/10.54985/peeref.2207p6946207.

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Sandeep, Bhushan, xin Huang, and Zongwei Xiao. Analgesic efficacy of erector spinae plane block in arthroscopic shoulder surgery: a systemic review and meta-analysis of randomised controlled trial. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0084.

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Review question / Objective: Erector spinae plane block (ESPB) has been employed in arthroscopic shoulder surgery (ASS) as an alternative novel interfacial plane block. However, its analgesic efficacy is still controversial. Whether ESPB could improve analgesic efficacy in ASS is what the current meta-analysis seeks to find out. Information sources: We searched different databases including the Cochrane Library, PubMed, Embase, and Web of Science from inception to November 29, 2022, using medical subject headings (MeSH) and free-text terms without language restrictions. The primary purpose of searching was for the selection of RCTs for meta-analysis but also to avoid unplanned duplication and compare reported review methods from other systematic reviews. The following search terms were used for the search of each database: “arthroscopic shoulder surgery”, “shoulder surgery”, “total shoulder arthroplasty”, “shoulder arthroscopy”, and “erector spinae plane block”, “erector spinae muscle”. We also searched for grey literature by supplementary hand searching.
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Watts, Charlotte, Karen Devries, Ligia Kiss, Tanya Abramsky, Nambusi Kyegombe, and Lori Michau. The SASA study: A cluster randomised controlled trial to assess the impact of a violence and HIV prevention programme in Kampala, Uganda. International Initiative for Impact Evaluation, October 2015. http://dx.doi.org/10.23846/ow31059.

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