Dissertations / Theses on the topic 'Randomised clinical trial (RCT)'
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Anjara, Sabrina Gabrielle. "A study of two models of primary mental health care provisions in Yogyakarta, Indonesia." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289729.
Full textDaures, Maguy. "Évaluation d'une stratégie de prise en charge simplifiée de la malnutrition aiguë chez des enfants de 6 à 59 mois en Afrique Sub-saharienne dans le cadre d’un programme de recherche co-construit entre humanitaires et chercheurs." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0067.
Full textAcute malnutrition (AM) is a major public health concern, affecting 45 million children under 5 years of age. It is an underlying cause of 800,000 deaths each year. Existing treatment protocols, while effective, suffer from insufficient funding and limited coverage. Furthermore, these protocols, divided into two programmes for severe and moderate acute malnourished children, are complex to put in place and use different treatments with sub-optimal dosages. In response to these challenges, the non-governmental organisation (NGO) The Alliance for medical action (ALIMA) has developed the « Optimising treatment for acute malnutrition » (OptiMA) protocol. The OptiMA aims to treat any children presenting Mid-Upper Arm Circumference (MUAC)<125 mm or oedema with a single ready-to-use therapeutic food (RUTF) with degressive dosage according to MUAC and weight In 2016, ALIMA, the GHiGS research team (Global Health in the Global South, Inserm/IRD/University of Bordeaux) in Bordeaux and the PAC-CI programme in Abidjan, founded the CORAL (Clinical and Operational Research Alliance) consortium in order to co-construct research activities between humanitarians and researchers in countries often forgotten by global research due to political instability and conflict. This thesis explores the evaluation of the OptiMA protocol through several studies, including a pilot trial in Burkina Faso and a randomized clinical trial in Niger, conducted within CORAL. A first pragmatic pilot trial "OptiMA Burkina Faso" was conducted in 2017 including 4,958 children with MUAC<125mm or oedema. The study has shown a good understanding of the OptiMA dosing table at district level, which led to a recovery rate of 86.3%. However, the lack of a comparison group was an issue, highlighting the need for more robust clinical trials. The CORAL consortium therefore initiated two clinical trials in different settings in the Democratic Republic of Congo (DRC) and Niger. This thesis work focuses on the OptiMA Niger trial, which evaluated two simplified AM management protocols, namely the OptiMA and the ComPAS "The Combined Protocol for Acute Malnutrition Study" strategies (interventions), which were compared with the Niger's national protocol (control). The ComPAS, developed by the NGO International Rescue Committee (IRC) with the same approach as OptiMA, determines the RUTF in a very simplified way, based solely on MUAC, and provides fewer RUTF than OptiMA. This three-arm, individually randomized, non-inferiority controlled trial, conducted in Mirriah, Niger, in 2021-22, included children aged 6-59 months with uncomplicated AM defined by MUAC<125 mm or oedema. The primary endpoint was the « favorable » outcome at 6 months, defined as being alive and without relapse. The secondary endpoint was nutritional recovery in children with MUAC<115 mm or oedema defined over 6 months as at least 4 weeks of treatment, absence of fever (>37.5°) and MUAC≥125 mm and no oedema for two consecutive weeks. Between 31 March and 23 December 2021, 1,732 children with MUAC <125 mm or oedema and 1,140 children with MUAC <115 mm or oedema were randomized (1:1:1). The findings did not demonstrate non-inferiority for any of the main outcomes, but the similar weight and MUAC gains trajectories 6 months post-randomization in the 3 arms suggest that the progressive reduction in supplementation did not have a negative impact on growth, even for the most vulnerable children, whereas 40% more children could be treated without increasing the cost of RUTFs. These trials have provided scientific evidence needed to scale up simplified protocols in emergency health setting. The CORAL consortium demonstrated its strength through the implementation of individually randomized clinical trials conducted rigorously in complex areas
Deak, Stefan, and Glenn Kristoffersson. "Rädslan för det som finns och inte finns : En randomiserad kontrollerad jämförelse av utfall mellan sedvanlig ensessionsbehandling och behandling med virtuella stimuli mot spindelfobi." Thesis, Stockholms universitet, Psykologiska institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-130712.
Full textVIMSE (VIrtual reality Method for Spider phobia Exposure therapy)
Nohlert, Eva. "Smoking Cessation : Treatment Intensity and Outcome in Randomized Clinical Trials." Doctoral thesis, Uppsala universitet, Centrum för klinisk forskning, Västerås, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208972.
Full textWalid, Rania. "Impact Evaluation in Post-conflict Environments : A Critical Appraisal of Randomised Controlled Trial (RCT)." Thesis, Linnéuniversitetet, Institutionen för samhällsstudier (SS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-104816.
Full textSpieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215848.
Full textSpieth, Peter Markus, Anne Sophie Kubasch, Ana Isabel Penzlin, Ben Min-Woo Illigens, Kristian Barlinn, and Timo Siepmann. "Randomized controlled trials - a matter of design." Dove Medical Press, 2016. https://tud.qucosa.de/id/qucosa%3A29007.
Full textFeatherstone, Katie. "Patient perspectives of participation in a randomised controlled trial." Thesis, University of Bristol, 2000. http://hdl.handle.net/1983/06229618-6e8d-4764-8c7a-1f0c0d0af307.
Full textSchuh, Sr Matthew Anderson. "The Epistemic Necessity and Ethical Permissibility of Randomized Clinical Trials: A Minimalist Defense." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/167.
Full textSlater, Karen. "Improving Care of Peripheral Intravenous Needleless Connectors." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/412414.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Nursing & Midwifery
Griffith Health
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Rickard, Claire. "Prolonged use of intravenous administration sets: a randomised controlled trial." Thesis, Queensland University of Technology, 2004. https://eprints.qut.edu.au/15974/1/Claire_Rickard_Thesis.pdf.
Full textRickard, Claire. "Prolonged use of intravenous administration sets: a randomised controlled trial." Queensland University of Technology, 2004. http://eprints.qut.edu.au/15974/.
Full textHenderson, Neil James Kerr. "Extending the clinical and economic evaluations of a randomised controlled trial the IONA study /." Connect to e-thesis, 2008. http://theses.gla.ac.uk/418/.
Full textPh.D. thesis submitted to the Department of Statistics, Faculty of Information and Mathematical Sciences, University of Glasgow, 2008. Includes bibliographical references. Print version also available.
Parkin, Nicola Ann. "Open versus closed exposure of palatally displaced canines : a randomised clinical trial." Thesis, University of Sheffield, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.575857.
Full textHandley, Alicia Katherine. "A randomised controlled trial of group cognitive behavioural therapy for clinical perfectionism." Thesis, Curtin University, 2014. http://hdl.handle.net/20.500.11937/802.
Full textAcharya, Dev Raj. "Measuring the effectiveness of teaching sex education in Nepalese secondary schools : an outcome from a Randomised Controlled Trial (RCT)." Thesis, Aberystwyth University, 2014. http://hdl.handle.net/2160/7aed061b-668e-4789-879e-b30ba401b6c6.
Full textWoodford, Joanne. "Development and feasibility randomised controlled trial of guided Cognitive Behavioural Therapy (CBT) self-help for informal carers of stroke survivors." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/17401.
Full textTohotoa, Jennifer Lynn. "The development, implementation and evaluation of a father inclusive perinatal support intervention to increase breastfeeding duration : a randomised controlled trial." Thesis, Curtin University, 2012. http://hdl.handle.net/20.500.11937/1542.
Full textMcArdle, Gerarde T. "A prospective randomised clinical trial comparing undergoing electric infrarenal abdominal aortic aneurysm repair." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534687.
Full textGuarino, Peter David. "Consumer participation in the design of informed consent documentation for entry into randomised clinical trials : a cluster randomised trial." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422313.
Full textWatson, Hunna J. "Clinical and research developments in the treatment of paediatric obsessive-compulsive disorder." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/2374.
Full textHutchison, Catherine B. "A randomised controlled trial of an audiovisual patient information intervention in cancer clinical trials." Thesis, University of Stirling, 2008. http://hdl.handle.net/1893/442.
Full textHenderson, Neil J. K. "Extending the clinical and economic evaluations of a randomised controlled trial : the IONA Study." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/418/.
Full textHoiles, Kimberley Jo. "A Randomised Controlled Trial of Guided Self-Help Cognitive Behaviour Therapy for Clinical Perfectionism." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/51902.
Full textCoskinas, Xanthi. "Changes to design aspects of ongoing randomised controlled trials." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29452.
Full textFerrante, di Ruffano Lavinia. "Using randomised controlled trials to evaluate the clinical effectiveness of diagnostic tests : how useful are test-treatment RCTs?" Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4269/.
Full textChuayna, Nonglak. "Implementing clinical guidelines in nurse-led primary health care in Thailand : a randomised controlled trial." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274428.
Full textFord, Shane Alwyn. "Delivering Acceptance and Commitment Therapy (ACT) for mental health disorders across group and guided self-help formats : a meta-analysis and randomised controlled trial." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25924.
Full textWatson, Hunna J. "Clinical and research developments in the treatment of paediatric obsessive-compulsive disorder." Curtin University of Technology, School of Psychology, Division of Health Sciences, 2007. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=115091.
Full textStudy 1 comprised the first known meta-analysis of randomised, controlled treatment trials (RCTs) for paediatric OCD. Included studies were limited to RCTs as they are the most scientifically valid means for determining treatment efficacy and provide a more accurate estimate of treatment effect by removing error variance associated with confounding variables. The literature search identified 13 RCTs containing 10 pharmacotherapy to control comparisons (N = 1016) and 5 CBT to control comparisons (N = 161). Random effects modelling yielded statistically significant pooled effect size (ES) estimates for pharmacotherapy (ES = 0.48, 95% CI = 0.36 to 0.61, p < .00001) and CBT (ES = 1.45, 95% CI = 0.68 to 2.22, p =.002). The results support the efficacy of CBT and pharmacotherapy, and confirm these approaches as the only two evidence-based treatments for paediatric OCD. Implications and suggestions for future research are discussed. The effectiveness of CBT provided impetus to further examine this treatment. Group CBT is an understudied treatment modality among children with OCD. It was hypothesised that group CBT would possess efficacy because of the effectiveness of individual CBT for children with OCD, the demonstrated effectiveness of group CBT among adults with OCD, the practical and therapeutic advantages afforded by a group treatment approach, and the embeddedness of the approach in robust psychological theory. The aim of the second study was to evaluate the efficacy of group CBT. The study comprised the largest known conducted randomised, placebo-controlled trial of group CBT for paediatric OCD.
Twenty-two children and adolescents with a primary diagnosis of OCD were randomly assigned to a 12-week program of group CBT or a credible psychological placebo. Children were assessed at baseline, end of treatment, and at 1 month follow-up. Outcome measures included the Children’s Yale-Brown Obsessive-Compulsive Scale, global measures of OCD severity, Children’s Depression Inventory, and parent- and child-rated measures of psychosocial functioning. An intention-to-treat analysis revealed that children in the group CBT condition had statistically significantly lower levels of symptomatology at posttreatment and follow-up compared to children in the placebo condition. Analysis of clinical significance showed that 91% of children that received CBT were ‘recovered’ or ‘improved’ at follow-up, whereas 73% of children in the placebo condition were ‘unchanged’. Effect size analysis using Cohen’s d derived an effect of 1.14 and 1.20 at posttreatment and follow-up, respectively. These effects are comparable to results from studies of individual CBT. This study supported group CBT as an effective treatment modality for paediatric OCD and demonstrated that the effect extends beyond placebo and nonspecific treatment factors. In addition to treatment efficacy, the inherent worth of a treatment lies in its adoption by the relevant clinical population. Children with OCD are known to be secretive and embarrassed about symptoms, and there is often a long delay between onset of symptoms and treatment-seeking (Simonds & Elliot, 2001). An important observation during the course of conducting the RCT was that a high rate (39%) of eligible families declined participation.
This led to the question, "What barriers prevent participation in group CBT for paediatric OCD?" Qualitative methodology was employed to address this research question. Eligible families that had declined participation in the RCT were contacted and invited to participate in semi-structured interviews that explored reasons for non-participation and positive and negative perceptions of group CBT. The average time between non-participation and interview was 1.33 years (SD = 3 months). Data were collected from nine families and thematic analysis methodology was utilised to identify emergent themes. Failure to participate was predicted by practical and attitudinal barriers. Practical barriers included a lack of time, distance, severity of OCD symptoms, financial, and child physical health. Attitudinal barriers included child embarrassment about OCD symptoms, child belief that therapy would be ineffective, fear of the social aspect of the group, lack of previous success with psychology, lack of trust in strangers, parental concern about the structure of the group, denial of a problem, and ‘not being ready for it’. Attitudinal barriers more frequently predicted treatment non-participation. Positive and negative perceptions of this treatment modality were informative. Parents showed no differences in preference for individual or group CBT. An important finding was that 56% of the children had not received treatment since parental expression of interest in the group CBT program. Application of the findings to methods that promote service utilisation is discussed.
Dakin, Helen A. "Economic evaluation of factorial randomised controlled trials." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:77eda1f6-dd8c-439a-8871-75fd57a4c7f5.
Full textWANZIRA, HUMPHREY. "Supportive Supervision as an approach to improve the quality of care for children with acute malnutrition in Arua district, Uganda: Baseline systematic assessment, Cluster Randomised Controlled Trial and Cost-Effectiveness Analysis." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2962380.
Full textLittleton, Heather, Amie E. Grills, Katherine D. Kline, Alexander M. Schoemann, and Julia Dodd. "The From Survivor to Thriver Program: RCT of an Online Therapist-Facilitated Program for Rape-Related PTSD." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/7326.
Full textMachai, Maria José Pires. "A school-based intervention for improving malaria-related knowledge and practices in Maputo Province, Mozambique : a randomised controlled trial." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3288.
Full textIncludes bibliographical references (leaves 63-66).
The aim of the study was to evaluate the impact of a school-based malaria education intervention and its effectiveness in the changing knowledge and practices related to malaria at randomly selected schools in Maputo Province.
Juriansz, A. "Conservative treatment of hallux valgus : a randomised controlled clinical trial of a hallux valgus night splint." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541455.
Full textNienhuis, Saskia Johanna. "Costs and effects of Doppler ultrasound measurements in suspected intrauterine growth retardation a randomised clinical trial /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6637.
Full textWiffen, Benjamin David Richard. "Online CBT for individuals with Christian beliefs : a pilot randomised controlled trial : and Clinical Research Portfolio." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5551/.
Full textGNESINI, Giulia. "REGULAR VERSUS RESCUE BUDESONIDE AND FORMOTEROL COMBINATION FOR MODERATE ASTHMA: A NON INFERIORITY RANDOMISED CLINICAL TRIAL." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389072.
Full textWang, Yanyi, and s3042947@student rmit edu au. "Evaluation of effectiveness and safety of acupuncture in the treatment of migraine: A systematic review and a randomised controlled trial." RMIT University. Health Science, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20091113.102639.
Full text曾偉賢 and Wai-yin Tsang. "Analysis of data from a double-blind, placebo-controlled randomised clinical trial for the treatment of stroke." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31977509.
Full textTsang, Wai-yin. "Analysis of data from a double-blind, placebo-controlled randomised clinical trial for the treatment of stroke." Hong Kong : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13787007.
Full textBagnall, Kara Marie. "Long-term follow-up of NetmumsHWD : a feasibility randomised controlled trial of telephone supported online behavioural activation for postnatal depression at 16 months post-randomisation." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15289.
Full textClough, Bonnie Anne. "Technological Adjuncts to Increase Adherence to Therapy: The Role of Mobile Phones." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366844.
Full textThesis (PhD Doctorate)
Doctor of Philosophy in Clinical Psychology (PhD ClinPsych)
School of Applied Psychology
Griffith Health
Full Text
Tagney, Jenny. "A randomised, clinical trial of a psycho-educational nursing intervention in patients receiving an Implantable Cardioverter Defibrillator." Thesis, University of the West of England, Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601373.
Full textWalker, Becky J. "A comparison of mandibular arch width changes using two different bracket systems : a randomised controlled clinical trial." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.681744.
Full textShore, Rob M. "A randomised controlled trial of an online mindfulness-based intervention for paranoia in a non-clinical population." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/808489/.
Full textSadler, Paul. "Cognitive behaviour therapy for insomnia and depression among older adults : A mixed methods randomised controlled clinical trial." Thesis, Federation University Australia, 2018. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/168037.
Full textDoctor of Philosophy
Williams, Catherine Elizabeth Mary. "A randomised controlled trial comparing two approaches to preschool vision screening in children under the age of 37 months." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285811.
Full textRussell, Trevor G. "Establishing the efficacy of telemedicine as a clinical tool for physiotherapists : from systems design to randomised controlled trial /." [St. Lucia, Qld.], 2004. http://adt.library.uq.edu.au/public/adt-QU20040608.114117/index.html.
Full textToth, Benjamin. "Clinical trials in British medicine 1858-1948, with special reference to the development of the randomised controlled trial." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364843.
Full textHaynes, Richard. "The safety, tolerability and biochemical efficacy of extended release niacin and laropiprant in a major randomised clinical trial." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:01ba360a-fe6a-4a1a-ba14-48a2dcc3e0dd.
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