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1

Movsesyan, Aleksandr. "Reliable Ethernet." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/602.

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Networks within data centers, such as connections between servers and disk arrays, need lossless flow control allowing all packets to move quickly through the network to reach their destination. This paper proposes a new algorithm for congestion control to satisfy the needs of such networks and to answer the question: Is it possible to provide circuit-less reliability and flow control in an Ethernet network? TCP uses an end-to-end congestion control algorithm, which is based on end-to-end round trip time (RTT). Therefore its flow control and error detection/correction approach is dependent on end-to-end RTT. Other approaches utilize specialized data link layer networks such as InfiniBand and Fibre Channel to provide network reliability. The algorithm proposed in this thesis builds on the ubiquitous Ethernet protocol to provide reliability at the data link layer without the overhead and cost of the specialized networks or the delay induced by TCP’s end-to-end approach. This approach requires modifications to the Ethernet switches to implement a back pressure based flow control algorithm. This back pressure algorithm utilizes a modified version of the Random Early Detection (RED) algorithm to detect congestion. Our simulation results show that the algorithm can quickly recover from congestion and that the average latency of the network is close to the average latency when no congestion is present. With correct threshold and alpha values, buffer sizes in the network and on the source nodes can be kept small to allow little needed additional hardware to implement the system.
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2

Li, Zhi. "Fuzzy logic based robust control of queue management and optimal treatment of traffic over TCP/IP networks." University of Southern Queensland, Faculty of Sciences, 2005. http://eprints.usq.edu.au/archive/00001461/.

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Improving network performance in terms of efficiency, fairness in the bandwidth, and system stability has been a research issue for decades. Current Internet traffic control maintains sophistication in end TCPs but simplicity in routers. In each router, incoming packets queue up in a buffer for transmission until the buffer is full, and then the packets are dropped. This router queue management strategy is referred to as Drop Tail. End TCPs eventually detect packet losses and slow down their sending rates to ease congestion in the network. This way, the aggregate sending rate converges to the network capacity. In the past, Drop Tail has been adopted in most routers in the Internet due to its simplicity of implementation and practicability with light traffic loads. However Drop Tail, with heavy-loaded traffic, causes not only high loss rate and low network throughput, but also long packet delay and lengthy congestion conditions. To address these problems, active queue management (AQM) has been proposed with the idea of proactively and selectively dropping packets before an output buffer is full. The essence of AQM is to drop packets in such a way that the congestion avoidance strategy of TCP works most effectively. Significant efforts in developing AQM have been made since random early detection (RED), the first prominent AQM other than Drop Tail, was introduced in 1993. Although various AQMs also tend to improve fairness in bandwidth among flows, the vulnerability of short-lived flows persists due to the conservative nature of TCP. It has been revealed that short-lived flows take up traffic with a relatively small percentage of bytes but in a large number of flows. From the user’s point of view, there is an expectation of timely delivery of short-lived flows. Our approach is to apply artificial intelligence technologies, particularly fuzzy logic (FL), to address these two issues: an effective AQM scheme, and preferential treatment for short-lived flows. Inspired by the success of FL in the robust control of nonlinear complex systems, our hypothesis is that the Internet is one of the most complex systems and FL can be applied to it. First of all, state of the art AQM schemes outperform Drop Tail, but their performance is not consistent under different network scenarios. Research reveals that this inconsistency is due to the selection of congestion indicators. Most existing AQM schemes are reliant on queue length, input rate, and extreme events occurring in the routers, such as a full queue and an empty queue. This drawback might be overcome by introducing an indicator which takes account of not only input traffic but also queue occupancy for early congestion notification. The congestion indicator chosen in this research is traffic load factor. Traffic load factor is in fact dimensionless and thus independent of link capacity, and also it is easy to use in more complex networks where different traffic classes coexist. The traffic load indicator is a descriptive measure of the complex communication network, and is well suited for use in FL control theory. Based on the traffic load indicator, AQM using FL – or FLAQM – is explored and two FLAQM algorithms are proposed. Secondly, a mice and elephants (ME) strategy is proposed for addressing the problem of the vulnerability of short-lived flows. The idea behind ME is to treat short-lived flows preferably over bulk flows. ME’s operational location is chosen at user premise gateways, where surplus processing resources are available compared to other places. By giving absolute priority to short-lived flows, both short and long-lived flows can benefit. One problem with ME is starvation of elephants or long-lived flows. This issue is addressed by dynamically adjusting the threshold distinguishing between mice and elephants with the guarantee that minimum capacity is maintained for elephants. The method used to dynamically adjust the threshold is to apply FL. FLAQM is deployed to control the elephant queue with consideration of capacity usage of mice packets. In addition, flow states in a ME router are periodically updated to maintain the data storage. The application of the traffic load factor for early congestion notification and the ME strategy have been evaluated via extensive experimental simulations with a range of traffic load conditions. The results show that the proposed two FLAQM algorithms outperform some well-known AQM schemes in all the investigated network circumstances in terms of both user-centric measures and network-centric measures. The ME strategy, with the use of FLAQM to control long-lived flow queues, improves not only the performance of short-lived flows but also the overall performance of the network without disadvantaging long-lived flows.
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3

Cheng, Wijian. "Automatic Red Tide Detection using MODIS Satellite Images." Scholar Commons, 2009. http://scholarcommons.usf.edu/etd/3772.

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Red tides pose a significant economic and environmental threat in the Gulf of Mexico. Detecting red tide is important for understanding this phenomenon. In this thesis, machine learning approaches based on Random Forests, Support Vector Machines and K-Nearest Neighbors have been evaluated for red tide detection from MODIS satellite images. Detection results using machine learning algorithms were compared to ship collected ground truth red tide data. This work has three major contributions. First, machine learning approaches outperformed two of the latest thresholding red tide detection algorithms based on bio-optical characterization by more than 10% in terms of F measure and more than 4% in terms of area under the ROC curve. Machine Learning approaches are effective in more locations on the West Florida Shelf. Second, the thresholds developed in recent thresholding methods were introduced as input attributes to the machine learning approaches and this strategy improved Random Forests and KNearest Neighbors approaches' F-measures. Third, voting the machine learning and thresholding methods could achieve the better performance compared with using machine learning alone, which implied a combination between machine learning models and biocharacterization thresholding methods can be used to obtain effective red tide detection results.
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4

Tinnakornsrisuphap, Peerapol. "Dynamics of random early detection gateway under a large number of TCP flows." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/200.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2004.
Thesis research directed by: Electrical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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5

Ghimire, Rajiv, and Mustafa Noor. "Evaluation and Optimization of Quality of Service (QoS) In IP Based Networks." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3920.

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The purpose of this thesis is to evaluate and analyze the performance of RED (Random Early Detection) algorithm and our proposed RED algorithm. As an active queue management RED has been considered an emerging issue in the last few years. Quality of service (QoS) is the latest issue in today’s internet world. The name QoS itself signifies that special treatment is given to the special traffic. With the passage of time the network traffic grew in an exponential way. With this, the end user failed to get the service for what they had paid and expected for. In order to overcome this problem, QoS within packet transmission came into discussion in internet world. RED is the active queue management system which randomly drops the packets whenever congestion occurs. It is one of the active queue management systems designed for achieving QoS. In order to deal with the existing problem or increase the performance of the existing algorithm, we tried to modify RED algorithm. Our purposed solution is able to minimize the problem of packet drop in a particular duration of time achieving the desired QoS. An experimental approach is used for the validation of the research hypothesis. Results show that the probability of packet dropping in our proposed RED algorithm during simulation scenarios significantly minimized by early calculating the probability value and then by calling the pushback mechanism according to that calculated probability value.
+46739567385(Rajiv), +46762125426(Mustafa)
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6

Abdel-Jaber, Hussein F. "Performance Modelling and Evaluation of Active Queue Management Techniques in Communication Networks. The development and performance evaluation of some new active queue management methods for internet congestion control based on fuzzy logic and random early detection using discrete-time queueing analysis and simulation." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4261.

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Since the field of computer networks has rapidly grown in the last two decades, congestion control of traffic loads within networks has become a high priority. Congestion occurs in network routers when the number of incoming packets exceeds the available network resources, such as buffer space and bandwidth allocation. This may result in a poor network performance with reference to average packet queueing delay, packet loss rate and throughput. To enhance the performance when the network becomes congested, several different active queue management (AQM) methods have been proposed and some of these are discussed in this thesis. Specifically, these AQM methods are surveyed in detail and their strengths and limitations are highlighted. A comparison is conducted between five known AQM methods, Random Early Detection (RED), Gentle Random Early Detection (GRED), Adaptive Random Early Detection (ARED), Dynamic Random Early Drop (DRED) and BLUE, based on several performance measures, including mean queue length, throughput, average queueing delay, overflow packet loss probability, packet dropping probability and the total of overflow loss and dropping probabilities for packets, with the aim of identifying which AQM method gives the most satisfactory results of the performance measures. This thesis presents a new AQM approach based on the RED algorithm that determines and controls the congested router buffers in an early stage. This approach is called Dynamic RED (REDD), which stabilises the average queue length between minimum and maximum threshold positions at a certain level called the target level to prevent building up the queues in the router buffers. A comparison is made between the proposed REDD, RED and ARED approaches regarding the above performance measures. Moreover, three methods based on RED and fuzzy logic are proposed to control the congested router buffers incipiently. These methods are named REDD1, REDD2, and REDD3 and their performances are also compared with RED using the above performance measures to identify which method achieves the most satisfactory results. Furthermore, a set of discrete-time queue analytical models are developed based on the following approaches: RED, GRED, DRED and BLUE, to detect the congestion at router buffers in an early stage. The proposed analytical models use the instantaneous queue length as a congestion measure to capture short term changes in the input and prevent packet loss due to overflow. The proposed analytical models are experimentally compared with their corresponding AQM simulations with reference to the above performance measures to identify which approach gives the most satisfactory results. The simulations for RED, GRED, ARED, DRED, BLUE, REDD, REDD1, REDD2 and REDD3 are run ten times, each time with a change of seed and the results of each run are used to obtain mean values, variance, standard deviation and 95% confidence intervals. The performance measures are calculated based on data collected only after the system has reached a steady state. After extensive experimentation, the results show that the proposed REDD, REDD1, REDD2 and REDD3 algorithms and some of the proposed analytical models such as DRED-Alpha, RED and GRED models offer somewhat better results of mean queue length and average queueing delay than these achieved by RED and its variants when the values of packet arrival probability are greater than the value of packet departure probability, i.e. in a congestion situation. This suggests that when traffic is largely of a non bursty nature, instantaneous queue length might be a better congestion measure to use rather than the average queue length as in the more traditional models.
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7

Duchemin, Tom. "Méthodologie d’analyse et de surveillance pour la prévention des arrêts maladie Hierarchizing Determinants of Sick Leave Insights From a Survey on Health and Well-being at the Workplace Response to Predictors of Long-Term Sick Leave in the Workplace Modeling sickness absence data : a scoping review A statistical algorithm for outbreak detection in a multi-site setting : the case of sick leave monitoring Monitoring sick leave data for early detection of influenza outbreaks." Thesis, Paris, HESAM, 2020. http://www.theses.fr/2020HESAC027.

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Alors que les arrêts maladie sont le signe d’un mal-être croissant chez les salariés et qu’ils pèsent un coût certain pour la collectivité, la numérisation et le partage systématique des données offrent de belles opportunités pour leur prévention. Nous avons ainsi profité de cette opportunité pour développer un éventail d’outils de prévention basés sur des méthodes d’analyse statistique. Dans un premier temps, ces travaux de thèse proposent une analyse des mécanismes expliquant les arrêts maladie chez le salarié. L’analyse d’une enquête nationale a premièrement permis d’identifier et de hiérarchiser leurs principaux facteurs déterminants grâce à l’algorithme des forêts aléatoires. Ensuite, une analyse de données administratives a identifié des trajectoires d’absence pouvant mener à des arrêts graves grâce à des analyses séquentielles et à de la modélisation multi-état. Dans un second temps, des outils ont été développés afin d’identifier des situations anormales d’arrêt maladie à l’échelle de l’entreprise. Une typologie d’entreprise a premièrement été construite afin de produire des valeurs repère pour que les entreprises évaluent précisément leur situation. Un algorithme de détection des pics d’absence, adapté de modèles de surveillance épidémiologique, a enfin été développé pour pouvoir identifier automatiquement les entreprises en excès
At a time when sick leave is a sign of growing ill-being for workers and a cost burden for the society, the systematic digitalization and distribution of data offers great opportunities for its prevention. We have therefore taken advantage of this opportunity to develop a range of prevention tools based on statistical analysis methods. In a first part, this work proposes an analysis of the mechanisms explaining sick leave among workers. The analysis of a national survey has first identified and prioritised their main determinants using random forest. Then, an analysis of administrative data had helped to identify absence trajectories that could lead to serious sick leaves thanks to sequential analyses and multi-state modelling. In a second step, tools were developed to identify abnormal situations of sick leave at company level. A company typology was first built to produce benchmark values for companies to accurately assess their situation. Finally, an algorithm for identifying absence peaks, adapted from epidemiological surveillance models, was finally developed to automatically identify companies in difficulty
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8

Jones, Christina Michele. "Applications and challenges in mass spectrometry-based untargeted metabolomics." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54830.

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Metabolomics is the methodical scientific study of biochemical processes associated with the metabolome—which comprises the entire collection of metabolites in any biological entity. Metabolome changes occur as a result of modifications in the genome and proteome, and are, therefore, directly related to cellular phenotype. Thus, metabolomic analysis is capable of providing a snapshot of cellular physiology. Untargeted metabolomics is an impartial, all-inclusive approach for detecting as many metabolites as possible without a priori knowledge of their identity. Hence, it is a valuable exploratory tool capable of providing extensive chemical information for discovery and hypothesis-generation regarding biochemical processes. A history of metabolomics and advances in the field corresponding to improved analytical technologies are described in Chapter 1 of this dissertation. Additionally, Chapter 1 introduces the analytical workflows involved in untargeted metabolomics research to provide a foundation for Chapters 2 – 5. Part I of this dissertation which encompasses Chapters 2 – 3 describes the utilization of mass spectrometry (MS)-based untargeted metabolomic analysis to acquire new insight into cancer detection. There is a knowledge deficit regarding the biochemical processes of the origin and proliferative molecular mechanisms of many types of cancer which has also led to a shortage of sensitive and specific biomarkers. Chapter 2 describes the development of an in vitro diagnostic multivariate index assay (IVDMIA) for prostate cancer (PCa) prediction based on ultra performance liquid chromatography-mass spectrometry (UPLC-MS) metabolic profiling of blood serum samples from 64 PCa patients and 50 healthy individuals. A panel of 40 metabolic spectral features was found to be differential with 92.1% sensitivity, 94.3% specificity, and 93.0% accuracy. The performance of the IVDMIA was higher than the prevalent prostate-specific antigen blood test, thus, highlighting that a combination of multiple discriminant features yields higher predictive power for PCa detection than the univariate analysis of a single marker. Chapter 3 describes two approaches that were taken to investigate metabolic patterns for early detection of ovarian cancer (OC). First, Dicer-Pten double knockout (DKO) mice that phenocopy many of the features of metastatic high-grade serous carcinoma (HGSC) observed in women were studied. Using UPLC-MS, serum samples from 14 early-stage tumor DKO mice and 11 controls were analyzed. Iterative multivariate classification selected 18 metabolites that, when considered as a panel, yielded 100% accuracy, sensitivity, and specificity for early-stage HGSC detection. In the second approach, serum metabolic phenotypes of an early-stage OC pilot patient cohort were characterized. Serum samples were collected from 24 early-stage OC patients and 40 healthy women, and subsequently analyzed using UPLC-MS. Multivariate statistical analysis employing support vector machine learning methods and recursive feature elimination selected a panel of metabolites that differentiated between age-matched samples with 100% cross-validated accuracy, sensitivity, and specificity. This small pilot study demonstrated that metabolic phenotypes may be useful for detecting early-stage OC and, thus, supports conducting larger, more comprehensive studies. Many challenges exist in the field of untargeted metabolomics. Part II of this dissertation which encompasses Chapters 4 – 5 focuses on two specific challenges. While metabolomic data may be used to generate hypothesis concerning biological processes, determining causal relationships within metabolic networks with only metabolomic data is impractical. Proteins play major roles in these networks; therefore, pairing metabolomic information with that acquired from proteomics gives a more comprehensive snapshot of perturbations to metabolic pathways. Chapter 4 describes the integration of MS- and NMR-based metabolomics with proteomics analyses to investigate the role of chemically mediated ecological interactions between Karenia brevis and two diatom competitors, Asterionellopsis glacialis and Thalassiosira pseudonana. This integrated systems biology approach showed that K. brevis allelopathy distinctively perturbed the metabolisms of these two competitors. A. glacialis had a more robust metabolic response to K. brevis allelopathy which may be a result of its repeated exposure to K. brevis blooms in the Gulf of Mexico. However, K. brevis allelopathy disrupted energy metabolism and obstructed cellular protection mechanisms including altering cell membrane components, inhibiting osmoregulation, and increasing oxidative stress in T. pseudonana. This work represents the first instance of metabolites and proteins measured simultaneously to understand the effects of allelopathy or in fact any form of competition. Chromatography is traditionally coupled to MS for untargeted metabolomics studies. While coupling chromatography to MS greatly enhances metabolome analysis due to the orthogonality of the techniques, the lengthy analysis times pose challenges for large metabolomics studies. Consequently, there is still a need for developing higher throughput MS approaches. A rapid metabolic fingerprinting method that utilizes a new transmission mode direct analysis in real time (TM-DART) ambient sampling technique is presented in Chapter 5. The optimization of TM-DART parameters directly affecting metabolite desorption and ionization, such as sample position and ionizing gas desorption temperature, was critical in achieving high sensitivity and detecting a broad mass range of metabolites. In terms of reproducibility, TM-DART compared favorably with traditional probe mode DART analysis, with coefficients of variation as low as 16%. TM-DART MS proved to be a powerful analytical technique for rapid metabolome analysis of human blood sera and was adapted for exhaled breath condensate (EBC) analysis. To determine the feasibility of utilizing TM-DART for metabolomics investigations, TM-DART was interfaced with traveling wave ion mobility spectrometry (TWIMS) time-of-flight (TOF) MS for the analysis of EBC samples from cystic fibrosis patients and healthy controls. TM-DART-TWIMS-TOF MS was able to successfully detect cystic fibrosis in this small sample cohort, thereby, demonstrating it can be employed for probing metabolome changes. Finally, in Chapter 6, a perspective on the presented work is provided along with goals on which future studies may focus.
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9

Lin, Wei-Chung, and 林偉正. "An Improved Random Early Detection (RED) Algorithm for Congestion Control." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/16896950377494718155.

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碩士
國立中興大學
資訊科學系所
95
Many proposals have been adopted in controlling the congestions in the routers, including Random Early Detection (RED) and Drop-tail, and have shown to improve the loss rate, throughput, fairness, etc. of the network. Although RED algorithm is designed for TCP for a active queue management, we found that when comes to dropping the packets, it treats packets equally, ignoring the effect of the the size of the packets. This results in higher loss rate of packets and lower throughput for smaller packets. In this thesis, we propose to improve the original RED algorithm by differentiating packet sizes and devise RED_average algorithm and further improved PS_average algorithm. We then use ns-2 to simulate the performance of the aforementioned three algorithm.based on three MTU sizes. The results showed that if we take the factor of the packet size into consideration, the RED_average algorithm has a better loss rate and throughput. The PS_average, which takes the average packet size into consideration to adjust the intended loss rate for smaller packates, has a even further improved performance. We have shown that by the above two new algorithms, a better balance for the loss rate for all packets can be achieved, and thus improved utilization of the network resources.
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10

Vaidya, Rahul. "Online Optimization Of RED Routers." Thesis, 2004. http://etd.iisc.ernet.in/handle/2005/1134.

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11

Patro, Rajesh Kumar. "A Nonlinear Stochastic Optimization Framework For RED." Thesis, 2005. http://etd.iisc.ernet.in/handle/2005/1439.

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12

Asfand-E-Yar, Irfan U. Awan, and Mike E. Woodward. "Performance modelling of a multiple threshold RED mechanism for bursty and correlated Internet traffic with MMPP arrival process." 2006. http://hdl.handle.net/10454/479.

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Access to the large web content hosted all over the world by users of the Internet engage many hosts, routers/switches and faster links. They challenge the internet backbone to operate at its capacity to assure e±cient content access. This may result in congestion and raises concerns over various Quality of Service (QoS) issues like high delays, high packet loss and low throughput of the system for various Internet applications. Thus, there is a need to develop effective congestion control mechanisms in order to meet various Quality of Service (QoS) related performance parameters. In this paper, our emphasis is on the Active Queue Management (AQM) mechanisms, particularly Random Early Detection (RED). We propose a threshold based novel analytical model based on standard RED mechanism. Various numerical examples are presented for Internet traffic scenarios containing both the burstiness and correlation properties of the network traffic.
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13

Zheng, Jing-Hong, and 鄭景鴻. "Using Random Early Detection to Improve Load Balancing in Unstructured P2P Networks." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/14144552035127001743.

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碩士
輔仁大學
資訊工程學系
99
The architecture of and the network formed by Peer-to-peer (P2P) technology is one of the most popular applications on the Internet. However, most of P2P networks currently in use operate in the form of unstructured style. The query broadcasting employed by the nodes to search for a file in unstructured networks often results in great burdens on the nodes. Furthermore, if nodes are located on popular paths, those nodes will receive more messages and have higher loads than others. How to reduce the load of the nodes in unstructured P2P networks is the major issue of this thesis. In this work, we propose a mechanism for forwarding and processing messages in unstructured P2P networks, which does not lead to overloads on the nodes. When a node searches for a file in unstructured P2P networks, it would use our method to choose the neighbors to send the Search Request messages to. When a node receives a Search Reply message, it would consider it own load situation to decide whether to forward the message or not. Simulation result shows that our method can save twenty percent on the number of messages of the network. When the average load of the network is heavy, we can choose a path those load is about three times less than not using the RED method. It means that our method can reduce the press of the nodes with heavy load, lower the standard deviation of the loads of all the nodes, and achieve the effect of balancing the load of the nodes over the network.
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14

Su, Guan-Yi, and 蘇冠伊. "Random Early Detection Improved by Progressive Adjustment Method and Its TI DaVinci Embedded System Implementation." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/71883036951672622976.

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碩士
雲林科技大學
電機工程系碩士班
96
With the rapid development of Internet services and applications, the demand for network bandwidth is ever-increasing. Network congestion issue is inevitably critical and gets widespread attention all the time. Hence, how to make good use of limited network bandwidth and solve the congestion issue effectively has always been one of the most popular topics. In this paper, a progressive adjustment method is proposed to improve on Active Queue Management (AQM), especially on Random Early Detection (RED) and Modified Random Early Detection (MRED). This reformed AQM is therefore referred to as Progressive Random Early Detection (PRED). According to the reasonable and practical factor of instantaneous queue size, the proposed PRED algorithm adjusts the maximum threshold dynamically at first. Then, based on conventional RED and MRED algorithms, it regulates the packet dropping probability nonlinearly by comparing the instantaneous queue size with the progressive maximum queue threshold parameters. So its flexibility can realize better network bandwidth utilization and management efficiency under various network conditions. This paper uses Network Simulator 2 (NS2) to run a series of simulations about performance comparison between RED, MRED, and PRED. Simulation results demonstrate that the proposed PRED algorithm can achieve highest transmission throughput and lowest end-to-end average delay for almost all network topologies.
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15

"Early Detection and Treatment of Breast Cancer by Random Peptide Array in neuN Transgenic Mouse Model." Doctoral diss., 2015. http://hdl.handle.net/2286/R.I.34916.

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abstract: Breast cancer is the most common cancer and currently the second leading cause of death among women in the United States. Patients’ five-year relative survival rate decreases from 99% to 25% when breast cancer is diagnosed late. Immune checkpoint blockage has shown to be a promising therapy to improve patients’ outcome in many other cancers. However, due to the lack of early diagnosis, the treatment is normally given in the later stages. An early diagnosis system for breast cancer could potentially revolutionize current treatment strategies, improve patients’ outcomes and even eradicate the disease. The current breast cancer diagnostic methods cannot meet this demand. A simple, effective, noninvasive and inexpensive early diagnostic technology is needed. Immunosignature technology leverages the power of the immune system to find cancer early. Antibodies targeting tumor antigens in the blood are probed on a high-throughput random peptide array and generate a specific binding pattern called the immunosignature. In this dissertation, I propose a scenario for using immunosignature technology to detect breast cancer early and to implement an early treatment strategy by using the PD-L1 immune checkpoint inhibitor. I develop a methodology to describe the early diagnosis and treatment of breast cancer in a FVB/N neuN breast cancer mouse model. By comparing FVB/N neuN transgenic mice and age-matched wild type controls, I have found and validated specific immunosignatures at multiple time points before tumors are palpable. Immunosignatures change along with tumor development. Using a late-stage immunosignature to predict early samples, or vice versa, cannot achieve high prediction performance. By using the immunosignature of early breast cancer, I show that at the time of diagnosis, early treatment with the checkpoint blockade, anti-PD-L1, inhibits tumor growth in FVB/N neuN transgenic mouse model. The mRNA analysis of the PD-L1 level in mice mammary glands suggests that it is more effective to have treatment early. Novel discoveries are changing understanding of breast cancer and improving strategies in clinical treatment. Researchers and healthcare professionals are actively working in the early diagnosis and early treatment fields. This dissertation provides a step along the road for better diagnosis and treatment of breast cancer.
Dissertation/Thesis
Doctoral Dissertation Biological Design 2015
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16

Min, Geyong, and X. Jin. "Analytical Modelling and Optimization of Congestion Control for Prioritized Multi-Class Self-Similar Traffic." 2013. http://hdl.handle.net/10454/9689.

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No
Traffic congestion in communication networks can dramatically deteriorate user-perceived Quality-of-Service (QoS). The integration of the Random Early Detection (RED) and priority scheduling mechanisms is a promising scheme for congestion control and provisioning of differentiated QoS required by multimedia applications. Although analytical modelling of RED congestion control has received significant research efforts, the performance models reported in the current literature were primarily restricted to the RED algorithm only without consideration of traffic scheduling scheme for QoS differentiation. Moreover, for analytical tractability, these models were developed under the simplified assumption that the traffic follows Short-Range-Dependent (SRD) arrival processes (e.g., Poisson or Markov processes), which are unable to capture the self-similar nature (i.e., scale-invariant burstiness) of multimedia traffic in modern communication networks. To fill these gaps, this paper presents a new analytical model of RED congestion control for prioritized multi-class self-similar traffic. The closed-form expressions for the loss probability of individual traffic classes are derived. The effectiveness and accuracy of the model are validated through extensive comparison between analytical and simulation results. To illustrate its application, the model is adopted as a cost-effective tool to investigate the optimal threshold configuration and minimize the required buffer space with congestion control.
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