Relevant bibliographies by topics / Raman SERS spectroscopy

Academic literature on the topic 'Raman SERS spectroscopy'

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Published: 14 March 2023

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Journal articles on the topic "Raman SERS spectroscopy"

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Ankamwar, Balaprasad, Ujjal Kumar Sur, and Pulak Das. "SERS study of bacteria using biosynthesized silver nanoparticles as the SERS substrate." Analytical Methods 8, no. 11 (2016): 2335–40. http://dx.doi.org/10.1039/c5ay03014e.

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Surface-enhanced Raman scattering (SERS) spectroscopy has great advantages as a spectroscopic analytical tool due to the large enhancement of the weak Raman signal and thereby facilitates suitable identification of chemical and biological systems.
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Frosch, Timea, Andreas Knebl, and Torsten Frosch. "Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy." Nanophotonics 9, no. 1 (December 9, 2019): 19–37. http://dx.doi.org/10.1515/nanoph-2019-0401.

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AbstractInnovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Raman spectroscopy, further application fields could be addressed, e.g. in situ pharmaceutical quality testing through the packaging. Raman optical activity, which enables the thorough analysis of specific chiral properties of drugs, can also be combined with SERS for signal enhancement. Besides SERS, micro- and nano-structured optical hollow fibers enable a versatile approach for Raman signal enhancement of pharmaceuticals. Within the fiber, the volume of interaction between drug molecules and laser light is increased compared with conventional methods. Advances in fiber-enhanced Raman spectroscopy point at the high potential for continuous online drug monitoring in clinical therapeutic diagnosis. Furthermore, fiber-array based non-invasive Raman spectroscopic chemical imaging of tablets might find application in the detection of substandard and counterfeit drugs. The discussed techniques are promising and might soon find widespread application for the detection and monitoring of drugs in various fields.
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Serebrennikova, Kseniya V., Anna N. Berlina, Dmitriy V. Sotnikov, Anatoly V. Zherdev, and Boris B. Dzantiev. "Raman Scattering-Based Biosensing: New Prospects and Opportunities." Biosensors 11, no. 12 (December 13, 2021): 512. http://dx.doi.org/10.3390/bios11120512.

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The growing interest in the development of new platforms for the application of Raman spectroscopy techniques in biosensor technologies is driven by the potential of these techniques in identifying chemical compounds, as well as structural and functional features of biomolecules. The effect of Raman scattering is a result of inelastic light scattering processes, which lead to the emission of scattered light with a different frequency associated with molecular vibrations of the identified molecule. Spontaneous Raman scattering is usually weak, resulting in complexities with the separation of weak inelastically scattered light and intense Rayleigh scattering. These limitations have led to the development of various techniques for enhancing Raman scattering, including resonance Raman spectroscopy (RRS) and nonlinear Raman spectroscopy (coherent anti-Stokes Raman spectroscopy and stimulated Raman spectroscopy). Furthermore, the discovery of the phenomenon of enhanced Raman scattering near metallic nanostructures gave impetus to the development of the surface-enhanced Raman spectroscopy (SERS) as well as its combination with resonance Raman spectroscopy and nonlinear Raman spectroscopic techniques. The combination of nonlinear and resonant optical effects with metal substrates or nanoparticles can be used to increase speed, spatial resolution, and signal amplification in Raman spectroscopy, making these techniques promising for the analysis and characterization of biological samples. This review provides the main provisions of the listed Raman techniques and the advantages and limitations present when applied to life sciences research. The recent advances in SERS and SERS-combined techniques are summarized, such as SERRS, SE-CARS, and SE-SRS for bioimaging and the biosensing of molecules, which form the basis for potential future applications of these techniques in biosensor technology. In addition, an overview is given of the main tools for success in the development of biosensors based on Raman spectroscopy techniques, which can be achieved by choosing one or a combination of the following approaches: (i) fabrication of a reproducible SERS substrate, (ii) synthesis of the SERS nanotag, and (iii) implementation of new platforms for on-site testing.
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Scott, B. L., and K. T. Carron. "Dynamic Surface Enhanced Raman Spectroscopy (SERS): Extracting SERS from Normal Raman Scattering." Analytical Chemistry 84, no. 20 (September 26, 2012): 8448–51. http://dx.doi.org/10.1021/ac301914a.

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Chen, Chuanpin, Wenfang Liu, Sanping Tian, and Tingting Hong. "Novel Surface-Enhanced Raman Spectroscopy Techniques for DNA, Protein and Drug Detection." Sensors 19, no. 7 (April 10, 2019): 1712. http://dx.doi.org/10.3390/s19071712.

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Surface-enhanced Raman spectroscopy (SERS) is a vibrational spectroscopic technique in which the Raman scattering signal strength of molecules, absorbed by rough metals or the surface of nanoparticles, experiences an exponential growth (103–106 times and even 1014–1015 times) because of electromagnetic or chemical enhancements. Nowadays, SERS has attracted tremendous attention in the field of analytical chemistry due to its specific advantages, including high selectivity, rich informative spectral properties, nondestructive testing, and the prominent multiplexing capabilities of Raman spectroscopy. In this review, we present the applications of state-of-the-art SERS for the detection of DNA, proteins and drugs. Moreover, we focus on highlighting the merits and mechanisms of achieving enhanced SERS signals for food safety and clinical treatment. The machine learning techniques, combined with SERS detection, are also indicated herein. This review concludes with recommendations for future studies on the development of SERS.
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Goeller, Lindsay J., and Mark R. Riley. "Discrimination of Bacteria and Bacteriophages by Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy." Applied Spectroscopy 61, no. 7 (July 2007): 679–85. http://dx.doi.org/10.1366/000370207781393217.

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Detection of pathogenic organisms in the environment presents several challenges due to the high cost and long times typically required for identification and quantification. Polymerase chain reaction (PCR) based methods are often hindered by the presence of polymerase inhibiting compounds and so direct methods of quantification that do not require enrichment or amplification are being sought. This work presents an analysis of pathogen detection using Raman spectroscopy to identify and quantify microorganisms without drying. Confocal Raman measurements of the bacterium Escherichia coli and of two bacteriophages, MS2 and PRD1, were analyzed for characteristic peaks and to estimate detection limits using traditional Raman and surface-enhanced Raman spectroscopy (SERS). MS2, PRD1, and E. coli produced differentiable Raman spectra with approximate detection limits for PRD1 and E. coli of 109 pfu/mL and 106 cells/mL, respectively. These high detection concentration limits are partly due to the small sampling volume of the confocal system but translate to quantification of as little as 100 bacteriophages to generate a reliable spectral signal. SERS increased signal intensity 103 fold and presented peaks that were visible using 2-second acquisitions; however, peak locations and intensities were variable, as typical with SERS. These results demonstrate that Raman spectroscopy and SERS have potential as a pathogen monitoring platform.
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Qiu, Yuxuan, Cuifang Kuang, Xu Liu, and Longhua Tang. "Single-Molecule Surface-Enhanced Raman Spectroscopy." Sensors 22, no. 13 (June 29, 2022): 4889. http://dx.doi.org/10.3390/s22134889.

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Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) has the potential to detect single molecules in a non-invasive, label-free manner with high-throughput. SM-SERS can detect chemical information of single molecules without statistical averaging and has wide application in chemical analysis, nanoelectronics, biochemical sensing, etc. Recently, a series of unprecedented advances have been realized in science and application by SM-SERS, which has attracted the interest of various fields. In this review, we first elucidate the key concepts of SM-SERS, including enhancement factor (EF), spectral fluctuation, and experimental evidence of single-molecule events. Next, we systematically discuss advanced implementations of SM-SERS, including substrates with ultra-high EF and reproducibility, strategies to improve the probability of molecules being localized in hotspots, and nonmetallic and hybrid substrates. Then, several examples for the application of SM-SERS are proposed, including catalysis, nanoelectronics, and sensing. Finally, we summarize the challenges and future of SM-SERS. We hope this literature review will inspire the interest of researchers in more fields.
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Abu-Hatab, Nahla A., Joshy F. John, Jenny M. Oran, and Michael J. Sepaniak. "Multiplexed Microfluidic Surface-Enhanced Raman Spectroscopy." Applied Spectroscopy 61, no. 10 (October 2007): 1116–22. http://dx.doi.org/10.1366/000370207782217842.

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Over the past few decades, surface-enhanced Raman spectroscopy (SERS) has garnered respect as an analytical technique with significant chemical and biological applications. SERS is important for the life sciences because it can provide trace level detection, a high level of structural information, and enhanced chemical detection. However, creating and successfully implementing a sensitive, reproducible, and robust SERS active substrate continues to be a challenging task. Herein, we report a novel method for SERS that is based upon using multiplexed microfluidics (MMFs) in a polydimethylsiloxane platform to perform parallel, high throughput, and sensitive detection/identification of single or various analytes under easily manipulated conditions. A facile passive pumping method is used to deliver Ag colloids and analytes into the channels where SERS measurements are done under nondestructive flowing conditions. With this approach, SERS signal reproducibility is found to be better than 7%. Utilizing a very high numerical aperture microscope objective with a confocal-based Raman spectrometer, high sensitivity is achieved. Moreover, the long working distance of this objective coupled with an appreciable channel depth obviates normal alignment issues expected with translational multiplexing. Rapid evaluation of the effects of anion activators and the type of colloid employed on SERS performance are used to demonstrate the efficiency and applicability of the MMF approach. SERS spectra of various pesticides were also obtained. Calibration curves of crystal violet (non-resonant enhanced) and Mitoxantrone (resonant enhanced) were generated, and the major SERS bands of these analytes were observable down to concentrations in the low nM and sub-pM ranges, respectively. While conventional random morphology colloids were used in most of these studies, unique cubic nanoparticles of silver were synthesized with different sizes and studied using visible wavelength optical extinction spectrometry, scanning electron microscopy, and the MMF-SERS approach.
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Canetta, Elisabetta. "Current and Future Advancements of Raman Spectroscopy Techniques in Cancer Nanomedicine." International Journal of Molecular Sciences 22, no. 23 (December 5, 2021): 13141. http://dx.doi.org/10.3390/ijms222313141.

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Raman scattering is one of the most used spectroscopy and imaging techniques in cancer nanomedicine due to its high spatial resolution, high chemical specificity, and multiplexity modalities. The flexibility of Raman techniques has led, in the past few years, to the rapid development of Raman spectroscopy and imaging for nanodiagnostics, nanotherapy, and nanotheranostics. This review focuses on the applications of spontaneous Raman spectroscopy and bioimaging to cancer nanotheranostics and their coupling to a variety of diagnostic/therapy methods to create nanoparticle-free theranostic systems for cancer diagnostics and therapy. Recent implementations of confocal Raman spectroscopy that led to the development of platforms for monitoring the therapeutic effects of anticancer drugs in vitro and in vivo are also reviewed. Another Raman technique that is largely employed in cancer nanomedicine, due to its ability to enhance the Raman signal, is surface-enhanced Raman spectroscopy (SERS). This review also explores the applications of the different types of SERS, such as SERRS and SORS, to cancer diagnosis through SERS nanoprobes and the detection of small-size biomarkers, such as exosomes. SERS cancer immunotherapy and immuno-SERS (iSERS) microscopy are reviewed.
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Tian, Z. Q., W. H. Li, B. W. Mao, S. Z. Zou, and J. S. Gao. "Potential-Averaged Surface-Enhanced Raman Spectroscopy." Applied Spectroscopy 50, no. 12 (December 1996): 1569–77. http://dx.doi.org/10.1366/0003702963904575.

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This paper describes a novel technique called potential-averaged surface-enhanced Raman spectroscopy (PASERS) which has several advantages over SERS. A PASERS spectrum is acquired when the electrode is rapidly modulated between two potentials by applying a square-wave voltage. The potential-averaged SERS spectrum contains all the information on the surface species at the two modulated potentials, and each individual SERS spectrum can then be extracted by deconvolution. By properly choosing the two modulating potentials, one can obtain SERS spectra of surface species at electrode potentials where SERS-active sites are normally unstable. PASERS also leads to a unique way of studying complex interfacial kinetic processes by controlling the voltage pulse height, frequency, and shape. Moreover, the measurement of time-resolved spectra in the very low vibrational frequency region can be achieved by PASERS with the use of a conventional scanning spectrometer with a single-channel detector. In this paper, the main advantages of PASERS are illustrated by studying two typical SERS systems, i.e., thiocyanate ion and thiourea adsorbed at silver electrodes, respectively. It is shown that the potential-averaging method can be applied as a common method to many other existing spectroelectrochemical techniques.
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Dissertations / Theses on the topic "Raman SERS spectroscopy"

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Sharma, Narayan. "Solution Processable Surface Enhanced Raman Spectroscopy (SERS) Substrate." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1434375587.

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Farazkhorasani, Fatemeh. "Raman and SERS studies of filamentous fungi." Royal Society of Chemistry, 2012. http://hdl.handle.net/1993/23855.

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Fungal species perform many important roles in biotechnology and recycling and act as agents of disease and decay. Surface-enhanced Raman scattering (SERS) has attracted significant attention as an analytical method for chemical and biological identification. For SERS experiments, it is essential to generate gold nanoparticles (AuNPs) with proper sizes and shapes. Raman and SERS imaging of fungi via in vivo synthesis of AuNPs were used to explore cellular components of Aspergillus nidulans (A. nidulans) cell. Critical parameters including pH, temperature and metal concentration affect the sizes and shapes of the NPs. For better control of NP formation (size, shape and location), pre-formed NP were incubated with A. nidulans colonies. Aspergillus nidulans outer hyphal walls were coated with NPs. Raman and SERS imaging of fungal walls revealed that proteins, carbohydrates and lipids are the main constituents of fungal cell wall.
October 2014
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Gühlke, Marina. "Oberflächenverstärkte Hyper-Raman-Streuung (SEHRS) und oberflächenverstärkte Raman-Streuung (SERS) für analytische Anwendungen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17570.

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Hyper-Raman-Streuung folgt anderen Symmetrieauswahlregeln als Raman-Streuung und profitiert als nicht-linearer Zweiphotonenprozess noch mehr von verstärkten elektromagnetischen Feldern an der Oberfläche plasmonischer Nanostrukturen. Damit könnte die oberflächenverstärkte Hyper-Raman-Streuung (SEHRS) praktische Bedeutung in der Spektroskopie erlangen. Durch die Kombination von SEHRS und oberflächenverstärkter Raman-Streuung (SERS) können komplementäre Strukturinformationen erhalten werden. Diese eignen sich aufgrund der Lokalisierung der Verstärkung auf die unmittelbare Umgebung der Nanostrukturen besonders für die Charakterisierung der Wechselwirkung zwischen Molekülen und Metalloberflächen. Ziel dieser Arbeit war es, ein tieferes Verständnis des SEHRS-Effekts zu erlangen und dessen Anwendbarkeit für analytische Fragestellungen einzuschätzen. Dazu wurden SEHRS-Experimente mit Anregung bei 1064 nm und SERS-Experimente mit Anregung bei derselben Wellenlänge sowie mit Anregung bei 532 nm - für eine Detektion von SEHRS und SERS im gleichen Spektralbereich - durchgeführt. Als Beispiel für nicht-resonante Anregung wurden die vom pH-Wert abhängigen SEHRS- und SERS-Spektren von para-Mercaptobenzoesäure untersucht. Mit diesen Spektren wurde die Wechselwirkung verschiedener Silbernanostrukturen mit den Molekülen charakterisiert. Anhand von beta-Carotin wurden Einflüsse von Resonanzverstärkung im SEHRS-Experiment durch die gleichzeitige Anregung eines molekularen elektronischen Übergangs untersucht. Dabei wurde durch eine Thiolfunktionalisierung des Carotins eine intensivere Wechselwirkung mit der Silberoberfläche erzielt, sodass nicht nur resonante SEHRS- und SERS-Spektren, sondern auch nicht-resonante SERS-Spektren von Carotin erhalten werden konnten. Die Anwendbarkeit von SEHRS für hyperspektrale Kartierung in Verbindung mit Mikrospektroskopie wurde durch die Untersuchung von Verteilungen verschiedener Farbstoffe auf strukturierten plasmonischen Oberflächen demonstriert.
Hyper-Raman scattering follows different symmetry selection rules than Raman scattering and, as a non-linear two-photon process, profits even more than Raman scattering from enhanced electromagnetic fields at the surface of plasmonic nanostructures. Surface-enhanced hyper-Raman scattering (SEHRS) could thus gain practical importance for spectroscopy. The combination of SEHRS and surface-enhanced Raman scattering (SERS) offers complementary structural information. Specifically, due to the localization of the enhancement to the close proximity of the nanostructures, this information can be utilized for the characterization of the interaction between molecules and metal surfaces. The aim of this work was to increase the understanding of the SEHRS effect and to assess its applicability to answer analytical questions. For that purpose, SEHRS experiments with excitation at 1064 nm and SERS experiments with excitation at the same wavelength, as well as with excitation at 532 nm - to detect SEHRS and SERS in the same spectral region - were conducted. As an example for non-resonant excitation, pH-dependent SEHRS and SERS spectra of para-mercaptobenzoic acid were examined. Based on these spectra, the interaction of different silver nanostructures with the molecules was characterized. beta-Carotene was used to study the influence of resonance enhancement by the excitation of a molecular electronic transition during SEHRS experiments. By the thiol-functionalization of carotene, a more intense interaction with the silver surface was achieved, which enables to obtain not only resonant SEHRS and SERS but also non-resonant SERS spectra of carotene. Hyperspectral SEHRS imaging in combination with microspectroscopy was demonstrated by analyzing the distribution of different dyes on structured plasmonic surfaces.
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Boddu, Naresh Kumar. "Trace analysis of biological compounds by surface enhanced Raman scattering (SERS) spectroscopy /." Connect to resource online, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1229542206.

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Chowdhury, Mustafa Habib. "The use of Surface Enhanced Raman Spectroscopy (SERS) for biomedical applications." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4816.

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Recent advances in nanotechnology and the biotechnology revolution have created an immense opportunity for the use of noble metal nanoparticles as Surface Enhanced Raman Spectroscopy (SERS) substrates for biological sensing and diagnostics. This is because SERS enhances the intensity of the Raman scattered signal from an analyte by orders of 106 or more. This dissertation deals with the different aspects involved in the application of SERS for biosensing. It discusses initial studies performed using traditional chemically reduced silver colloidal nanoparticles for the SERS detection of a myriad of proteins and nucleic acids. It examines ways to circumvent the inherent aggregation problems associated with colloidal nanoparticles that frequently lead to poor data reproducibility. The different methods examined to create robust SERS substrates include the creation of thermally evaporated silver island films on microscope glass slides, using the technique of Nanosphere Lithography (NSL) to create hexagonally close packed periodic particle arrays of silver nanoparticles on glass substrates as well as the use of optically tunable gold nanoshell films on glass substrates. The three different types of SERS surfaces are characterized using UV-Vis absorption spectroscopy, Electron Microscopy (EM), Atomic Force Microscopy (AFM) as well as SERS using the model Raman active molecule trans-1,2-bis(4-pyridyl)ethylene (BPE). Also discussed is ongoing work in the initial stages of the development of a SERS based biosensor using gold nanoshell films for the direct detection of b-amyloid, the causative agent for Alzheimer's disease. Lastly, the use of gold nanoshells as SERS substrates for the intracellular detection of various biomolecules within mouse fibroblast cells in cell culture is discussed. The dissertation puts into perspective how this study can represent the first steps in the development of a robust gold nanoshell based SERS biosensor that can improve the ability to monitor biological processes in real time, thus providing new avenues for designing systems for the early diagnosis of diseases.
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Noonan, Jonathan. "Surfaced enhanced Raman spectroscopy (SERS) for the molecular imaging of atherosclerosis." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8939/.

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Cardiovascular diseases are the leading cause of mortality worldwide, with the majority of these deaths being a result of the inflammatory pathology, atherosclerosis. A critical need for multi-parameter molecular imaging has been identified to facilitate improved atherosclerosis diagnosis and the understanding of local inflammatory pathways in humans. Established imaging modalities such as ultrasound and magnetic resonance imaging are being investigated as potential solutions to this clinical problem, however, inherent limitations with these technologies have resulted in the exploration of alternate imaging approaches. This thesis focuses on the development and testing of surface enhanced Raman spectroscopy (SERS), a promising and novel molecular imaging modality, for the molecular imaging of vascular inflammatory biomarkers in vitro, ex vivo and in vivo. SERS detects molecule specific vibrational signals which are enhanced when an analyte is excited with light in close proximity to a noble metal surface. To achieve molecular specificity and surface enhancement, we developed antibody functionalised gold nanoparticles (nanotags) designed to bind to our molecular targets of interest, the adhesion molecules, intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and P-selectin, and produce a SERS signal detectable by spectroscopy and/or microscopy based approaches. In vitro, we demonstrate the simultaneous and quantifiable SERS detection of ICAM-1, VCAM-1 and P-selectin on TNFa stimulated human endothelial cells. We subsequently demonstrated the simultaneous SERS detection of ICAM-1, VCAM-1 and P-selectin in freshly isolated atherosclerotic human coronary artery ex vivo. Finally, we explored SERS imaging in a humanised mouse model, demonstrating non-invasive multiplex imaging of adhesion molecules in vivo. In summary, this proof of concept study demonstrates the suitability of SERS and nanotags for the non-invasive molecular imaging of vascular inflammation. We have tested this approach with increasing biological complexity and highlighted SERS as a potential molecular imaging tool for future clinical translation in the context of vascular inflammation, atherosclerosis and cardiovascular disease.
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Marotta, Nicole Ella. "Patterned nanoarray sers substrates for pathogen detection." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37274.

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The objectives of the work presented were to 1) fabricate reproducible nanorod array SERS substrates, 2) detection of bacteria using nanorod substrates, 3) detection of DNA hybridization using nanorod substrates and 4) critically evaluate the sensing method. Important findings from this work are as follows. A novel method for batch fabrication of substrates for surface enhanced Raman scattering (SERS) has been developed using a modified platen machined to fit in a commercial electron beam evaporator. The use of this holder enables simultaneous deposition of silver nanorod (AgNR) arrays onto six microscope slide substrates utilizing glancing angle deposition. In addition to multiple substrate fabrication, patterning of the AgNR substrates with 36 wells allows for physical isolation of low volume samples. The well-to-well, slide-to-slide, and batch-to-batch variability in both physical characteristics and SERS response of substrates prepared via this method was nominal. A critical issue in the continued development of AgNR substrates is their stability over time, and the potential impact on the SERS response. The thermal stability of the arrays was investigated and changes in surface morphology were evaluated using scanning electron microscopy and x-ray diffraction and correlated with changes in SERS enhancement. The findings suggest that the shelf-life of AgNR arrays is limited by migration of silver on the surface. Continued characterization of the AgNR arrays was carried out using fluorescent polystyrene microspheres of two different sizes. Theory suggests that enhancement between nanorods would be significantly greater than at the tops due to contributing electromagnetic fields from each nanostructure. In contrast to the theory, SERS response of microspheres confined to the tops of the AgNR array was significantly greater than that for beads located within the array. The location of the microspheres was established using optical fluorescence and scanning electron microscopy. The application of SERS to characterizing pathogens such as bacteria and viruses is an active area of investigation. AgNR array-based SERS substrates have enabled detection of pathogens present in biofluids. Specifically, several publications have focused on determining the spectral bands characteristic of bacteria from different species and cell lines. Studies were carried out on three strains of bacteria as well as the medium in which the bacteria were grown. The spectra of the bacteria and medium were surprisingly similar, so additional spectra were acquired for commonly used bacterial growth media. In many instances, these spectra were similar to published spectra purportedly characteristic of specific bacterial species. In addition to bacterial samples, nucleic acid hybridization assays were investigated. Oligonucleotide pairs specifically designed to detect respiratory syncytial virus (RSV) in nasal fluids were prepared and evaluated. SERS spectra acquired on oligos, alone or in combination, contain the known spectral signatures of the nucleosides that comprise the oligo. However, spectra acquired on an oligo with a 5'- or 3' thiol were distinctly different from that acquired on the identical oligo without a thiol pendant group suggesting some control over the orientation of the oligo on the nanorod surface. The signal enhancement in SERS depends markedly upon the location of the probe relative to the substrate surface. By systematic placement of nucleotide markers along the oligo chain, the point at which the nucleotide disappears from the spectrum was identified. The overall findings for AgNR SERS substrates suggest that the applicability of SERS for detecting nucleic acid hybridization is limited. The strong distance dependence coupled with the lack of substrate stability at temperatures required for annealing oligos during hybridization suggest that AgNRs are not the platform to use for hybridization assays.
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Gant, Virgil Alexander. "Detection of integrins using surface enhanced raman spectroscopy." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/2304.

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Integrins are transmembrane heterodimer protein receptors that mediate adherence to both the intracellular cytoskeleton and extracellular matrix. They play a major role in cellular adhesion and the breadth of their importance in biology is only recently being understood. The ability to detect concentrations of integrins on the cell surface, spatially resolve them, and study the dynamics of their behavior would be a significant advance in this field. Ultimately, the ability to detect dynamic changes of integrins on the surface of a cell maybe possible by developing a combined device such as an atomic force microscope (AFM) and surface enhanced Raman spectroscopy (SERS) system. However, the focus of this research is to first determine if integrins can be detected using SERS. Surface enhanced Raman spectroscopy (SERS) is technique used to detect the presence of analytes at the nanomolar level or below, through detection of inelastically scattered light. This thesis discusses the detection of integrins employing SERS as the detection modality. Integrins have been detected, in solution, using two silver colloids as the enhancing surface. Two silver colloid preparation methods are compared by ease of formulation and degree of enhancement in this thesis. Citrate and hydroxylamine hydrochloride (HA-HCl) reduced silver colloids were prepared through wet chemistry,compared using UV-Vis light spectroscopy, and tested for surface enhancement using adenine (a strong SERS active molecule), and two different integrins, (alpha)V(beta)3 and (alpha)5(beta)1. Results indicated that both colloids demonstrate SERS activity for varying concentrations of adenine as compared to standard non-enhanced Raman, however, only the citrate reduced colloid showed significant enhancement effect for the integrins.
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Ochsenkühn, Michael Andreas. "Modern Raman spectroscopy for investigation of host-pathogen interactions." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4760.

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Biomedical sciences are in need of more versatile and more sensitive approaches for research and also for diagnostic purposes. In particular, intracellular detection and imaging of disease relevant proteins is a challenge. Although the state of the art method of intracellular imaging is fluorescence, it suffers from several drawbacks. Raman is an alternative imaging modality and this work investigates the use of different Raman techniques for detection and imaging of cellular constituents. In one aspect of the work, surface-enhanced Raman spectroscopy using gold nanoshells excitable at a wavelength of 780 nm was investigated. Initially the investigation of the uptake of the 150 nm diameter nanoparticles showed that NS are taken up voluntarily by a non-standard en- docytosis mechanism into mammalian fibroblast cells. Furthermore it was shown that internalized particles have no detrimental in uence on cell growth or cell viability. That these nanoparticles are non toxic was further confirmed by testing for markers of apoptosis and necrosis. Preliminary surface-enhanced Raman spectroscopy (SERS) studies produced spectra from intracellular compartments with an enhancement factor of 1010. To yield high specificity of the intracellular Raman protein sensor, two different approaches were studied. The first is based on the application of DNA aptamers which form a stacked G-quadruplex on target protein binding. A SERS sensor based on the well characterized Thrombin binding aptamer (TBA) yielded high reproducibility, high target specificity, and a limit of detection down to 0.1 fM. Further studies on a similar stacked G-quadruplex forming aptamer confirmed that observed detection signal is produced by the aptamer assuming its secondary structure but also showed that the stabilization and formation of the G-quadruplex secondary structure is strongly buffer dependent. A second sensing approach was based on a peptide (a3(IV)NC1) influential in Goodpasture's syndrome, an autoimmune disease. With the help of this peptide we found that an intracellular redoxpotential of -200 mV is necessary to make it accessible for the protease Cathepsin D. We found that SERS sensing has the ability to study the binding of Cathepsin D, its activity and with the help of a synthesized amino-acid SERS library the direct detection of the remaining peptide products. Finally this work concludes with imaging the changes of lipid droplet structure and distribution in fibroblast cells during the infection process of the murine cytomegalovirus (MCMV) in fixed and in living cells by coherent anti-Stokes Raman based on a Synchro-lock phase coupled setup. This showed that CARS imaging is able to non-invasively investigate the changes of lipid structures during different stages of the infection process and therefore promises to be a valuable tool in biological research.
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Sirimuthu, Narayana M. S. "Increasing the range and reproducibility of quantitative surface-enhanced Raman spectroscopy (SERS)." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431477.

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Books on the topic "Raman SERS spectroscopy"

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Baia, Monica. Raman and SERS investigations of pharmaceuticals. Berlin: Springer, 2008.

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Astilean, Simion, Traian Iliescu, and Monica Baia. Raman and SERS Investigations of Pharmaceuticals. Springer Berlin / Heidelberg, 2010.

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Hayazawa, Norihiko, and Prabhat Verma. Nanoanalysis of materials using near-field Raman spectroscopy. Edited by A. V. Narlikar and Y. Y. Fu. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199533053.013.10.

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This article describes the use of tip-enhanced near-field Raman spectroscopy for the characterization of materials at the nanoscale. Tip-enhanced near-field Raman spectroscopy utilizes a metal-coated sharp tip and is based on surface-enhanced Raman scattering (SERS). Instead of the large surface enhancement from the metallic surface in SERS, the sharp metal coated tip in the tip-enhanced Raman scattering (TERS) provides nanoscaled surface enhancement only from the sample molecules in the close vicinity of the tip-apex, making it a perfect technique for nanoanalysis of materials. This article focuses on near-field analysis of some semiconducting nanomaterials and some carbon nanostructures. It first considers SERS analysis of strained silicon and TERS analysis of epsilon-Si and GaN thin layers before explaining how to improve TERS sensitivity and control the polarization in detection for crystalline materials. It also discusses ways of improving the spatial resolution in TERS.
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Kodali, Anil K., and Rohit Bhargava. Nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications. Edited by A. V. Narlikar and Y. Y. Fu. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199533060.013.15.

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This article describes the use of nanostructured probes to enhance optical and vibrational spectroscopic imaging for biomedical applications. Engineered probes and surfaces are promising tools for enhancing signals for ultrasensitive detection of diseases like carcinoma. Two methods of interest are surface-enhanced infrared absorption (SEIRA) spectroscopy and surface-enhanced Raman spectroscopy (SERS) for IR and Raman modalities, respectively. SERS and SEIRA can be broadly categorized under a common modality termed surface-enhanced vibrational spectroscopy. This article first reviews various breakthrough findings reported in SERS and SEIRA, along with different types ofsubstrates and contrast agents used in realizing the enhancement and theories proposed to explain these findings. It then considers the configurations of nano-LAMPs and presents example results demonstrating their optical resonances and tunability. Finally, it evaluates a few techniques for fabricating multilayered nanoparticles and highlights some issues with respect to fabrication.
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Book chapters on the topic "Raman SERS spectroscopy"

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Wang, Yuling, and Erkang Wang. "Nanoparticle SERS Substrates." In Surface Enhanced Raman Spectroscopy, 39–69. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527632756.ch2.

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Bell, Steven E. J., and Alan Stewart. "Quantitative SERS Methods." In Surface Enhanced Raman Spectroscopy, 71–86. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527632756.ch3.

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Pînzaru, Simona Cîntă, and Ioana E. Pavel. "SERS and Pharmaceuticals." In Surface Enhanced Raman Spectroscopy, 129–54. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527632756.ch6.

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Henkel, Thomas, Anne März, and Jürgen Popp. "SERS and Microfluidics." In Surface Enhanced Raman Spectroscopy, 173–90. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527632756.ch8.

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Prochazka, Marek. "Bioanalytical SERS Applications." In Surface-Enhanced Raman Spectroscopy, 61–91. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23992-7_4.

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Prochazka, Marek. "Biomolecular SERS Applications." In Surface-Enhanced Raman Spectroscopy, 93–125. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23992-7_5.

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Hobro, Alison J., and Bernhard Lendl. "SERS and Separation Science." In Surface Enhanced Raman Spectroscopy, 155–71. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527632756.ch7.

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Prochazka, Marek. "Medical Applications of SERS." In Surface-Enhanced Raman Spectroscopy, 149–211. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-23992-7_7.

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Muniz-Miranda, Maurizio, Cristina Gellini, and Massimo Innocenti. "SERS Spectroscopy and Microscopy." In Raman Spectroscopy for Nanomaterials Characterization, 553–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-20620-7_20.

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Maher, Robert C. "SERS Hot Spots." In Raman Spectroscopy for Nanomaterials Characterization, 215–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-20620-7_10.

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Conference papers on the topic "Raman SERS spectroscopy"

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Gellner, Magdalena, Hannes Kuchelmeister, Carsten Schmuck, Sebastian Schlücker, P. M. Champion, and L. D. Ziegler. "SERS and Solid Phase Synthesis." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482275.

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Marković, Marina, Tomislav Biljan, P. M. Champion, and L. D. Ziegler. "SERS Quantification of Entacapone Isomers." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482278.

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Tam, Felicia, Marcelo E. Piotti, Emily Stone, R. Griffith Freeman, P. M. Champion, and L. D. Ziegler. "Molecule Size-Dependent SERS Enhancement." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482934.

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Seo, H. K., W. J. Hong, D. H. Kang, S. R. Ryu, Y. M. Jung, P. M. Champion, and L. D. Ziegler. "Application of SERS Immunoassay for Biosensing." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482270.

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Carrillo-Carriòn, Carolina, Bartolomé M. Simonet, Miguel Valcárcel, Bernhard Lendl, P. M. Champion, and L. D. Ziegler. "SERS Detection in Capillary Separation Systems." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482286.

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Shin, Ka Yeong, Kyungtag Ryu, Hoik Lee, Jinwoo Kim, Daewon Sohn, Hoeil Chung, P. M. Champion, and L. D. Ziegler. "Nanoparticle Encapsulated Hydrogel for SERS Measurement." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482305.

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Tisinger, Louis, Enrique Lozano Diz, Rosalind Wolstenholme, Leesa Ferguson, P. M. Champion, and L. D. Ziegler. "Fingerprints..[ellipsis (horizontal)] Fingerprinted by SERS!!!" In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482472.

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Zhao, Yiping, Yongjun Liu, P. M. Champion, and L. D. Ziegler. "The Silver Nanorod Array SERS Substrates." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482510.

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Van Duyne, Richard P., P. M. Champion, and L. D. Ziegler. "Single Molecule and Single Particle SERS." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482687.

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Han, Sang Woo, P. M. Champion, and L. D. Ziegler. "SERS From The Self-Assembled Nanostructures." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482915.

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Reports on the topic "Raman SERS spectroscopy"

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Sheng, Dai, and B. Gu. A New Method for In-situ Characterization of Important Actinides and Technetium Compounds via Fiberoptic Surface Enhanced Raman Spectroscopy (SERS). Office of Scientific and Technical Information (OSTI), September 2005. http://dx.doi.org/10.2172/893264.

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Dai, Sheng, and B. Gu. A New Method for In-situ Characterization of Important Actinides and Technetium Compounds via Fiberoptic Surface Enhanced Raman Spectroscopy (SERS). Office of Scientific and Technical Information (OSTI), June 2002. http://dx.doi.org/10.2172/834954.

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Dai, Sheng, and B. Gu. A New Method for In-situ Characterization of Important Actinides and Technetium Compounds via Fiberoptic Surface Enhanced Raman Spectroscopy (SERS). Office of Scientific and Technical Information (OSTI), June 2003. http://dx.doi.org/10.2172/834955.

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Dai, Sheng, and B. Gu. A New Method for In-situ Characterization of Important Actinides and Technetium Compounds via Fiberoptic Surface Enhanced Raman Spectroscopy (SERS). Office of Scientific and Technical Information (OSTI), June 2004. http://dx.doi.org/10.2172/839076.

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