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Journal articles on the topic 'Railway, degraded adhesion, adhesion model'

Author: Grafiati
Published: 10 March 2023

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1

Meli, E., A. Ridolfi, and A. Rindi. "An innovative degraded adhesion model for railway vehicles: development and experimental validation." Meccanica 49, no. 4 (2013): 919–37. http://dx.doi.org/10.1007/s11012-013-9839-z.

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2

Meli, E., L. Pugi, and A. Ridolfi. "An innovative degraded adhesion model for multibody applications in the railway field." Multibody System Dynamics 32, no. 2 (2013): 133–57. http://dx.doi.org/10.1007/s11044-013-9400-9.

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3

Meli, E., and A. Ridolfi. "An innovative wheel–rail contact model for railway vehicles under degraded adhesion conditions." Multibody System Dynamics 33, no. 3 (2013): 285–313. http://dx.doi.org/10.1007/s11044-013-9405-4.

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4

Allotta, B., E. Meli, A. Ridolfi, and A. Rindi. "Development of an innovative wheel–rail contact model for the analysis of degraded adhesion in railway systems." Tribology International 69 (January 2014): 128–40. http://dx.doi.org/10.1016/j.triboint.2013.09.013.

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5

Allotta, B., R. Conti, E. Meli, L. Pugi, and A. Ridolfi. "Development of a HIL railway roller rig model for the traction and braking testing activities under degraded adhesion conditions." International Journal of Non-Linear Mechanics 57 (December 2013): 50–64. http://dx.doi.org/10.1016/j.ijnonlinmec.2013.06.003.

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6

Zirek, Abdulkadir, and Altan Onat. "A novel anti-slip control approach for railway vehicles with traction based on adhesion estimation with swarm intelligence." Railway Engineering Science 28, no. 4 (2020): 346–64. http://dx.doi.org/10.1007/s40534-020-00223-w.

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AbstractAnti-slip control systems are essential for railway vehicle systems with traction. In order to propose an effective anti-slip control system, adhesion information between wheel and rail can be useful. However, direct measurement or observation of adhesion condition for a railway vehicle in operation is quite demanding. Therefore, a proportional–integral controller, which operates simultaneously with a recently proposed swarm intelligence-based adhesion estimation algorithm, is proposed in this study. This approach provides determination of the adhesion optimum on the adhesion-slip curv
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Uyulan, Çağlar, and Metin Gokasan. "Modeling, simulation and re-adhesion control of an induction motor–based railway electric traction system." Proceedings of the Institution of Mechanical Engineers, Part I: Journal of Systems and Control Engineering 232, no. 1 (2017): 3–11. http://dx.doi.org/10.1177/0959651817732487.

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Increasing the traction force is a complex problem in the design of railway vehicles; therefore, effective traction systems and algorithms have to be developed. During the traction process, the verification of traction algorithms and control strategies are based on simulations covering all locomotive dynamics. In this article, traction model of a railway vehicle and re-adhesion control method based on simulation approach are investigated to obtain more effective results. The longitudinal dynamic of a railway vehicle having traction system, which comprises two parallel motor groups, each of whi
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Bureika, Gintautas. "A MATHEMATICAL MODEL OF TRAIN CONTINUOUS MOTION UPHILL." TRANSPORT 23, no. 2 (2008): 135–37. http://dx.doi.org/10.3846/1648-4142.2008.23.135-137.

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The determination problem of adhesion coefficient of locomotives’ wheels with rails is described in this paper. The use of methods of mathematical statistics and theory of probability provides wider possibilities for determining the most acceptable (suitable) value of the adhesion coefficient. The random factors influencing on this value are analysed. The use of the adhesion coefficient values based on reliable research results could help maintain uninterrupted (continuous) traffic of heavy freight trains and increase not only the carrying capacity, but also the volume of the transported goods
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Li, Yun Feng, Xiao Yun Feng, and Rui Kuo Liu. "Maximum Adhesion Control of Railway Based on Sliding Mode Control System." Advanced Materials Research 383-390 (November 2011): 5242–49. http://dx.doi.org/10.4028/www.scientific.net/amr.383-390.5242.

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The wheels will idle when the relative slipping speed between the wheel and rail exceeds the reference slipping speed. In order to avoid this phenomenon, the simplified model of wheel-rail traction torque transmission was established. And the adhesion coefficient and vehicle velocity are got through the disturbance observer. Then the recursive least squares method was used to forecast the slope of the adhesion-slip curve. Sliding variable structure controller was used to control the error of wheel velocity and reference velocity. From the results of simulation, this method can be effective to
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10

Olofsson, U. "A multi-layer model of low adhesion between railway wheel and rail." Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit 221, no. 3 (2007): 385–89. http://dx.doi.org/10.1243/09544097jrrt111.

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11

Tsai, S.-W., J.-F. Fang, C.-L. Yang, J.-H. Chen, L.-T. Su, and S.-H. Jan. "Preparation and Evaluation of a Hyaluronate-Collagen Film for Preventing Post-Surgical Adhesion." Journal of International Medical Research 33, no. 1 (2005): 68–76. http://dx.doi.org/10.1177/147323000503300106.

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Post-surgical adhesion occurs when fibrous strands of scar tissue form, leading to the abnormal joining of anatomical structures. Patients undergoing abdominal surgery are at risk of the complications associated with intraperitoneal adhesions. Hyaluronic acid (HA) is a biocompatible, biodegradable and non-toxic natural polymer, which is gaining popularity as a barrier agent for preventing post-surgical adhesions. As HA is water-soluble and rapidly degraded in vivo, chemical modification is required to produce a non-soluble sheet that might be used to prevent tissue adhesion. We developed a ran
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12

Allota, B., R. Conti, E. Meli, L. Pugi, and A. Ridolfi. "Railway Vehicle Dynamics under Degraded Adhesion Conditions: An Innovative HIL Architecture for Braking Tests on Full-Scale Roller-Rigs." International Journal of Railway Technology 2, no. 3 (2013): 21–53. http://dx.doi.org/10.4203/ijrt.2.3.2.

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13

Allotta, Benedetto, Roberto Conti, Enrico Meli, and Alessandro Ridolfi. "Modeling and Control of a Full-Scale Roller-Rig for the Analysis of Railway Braking Under Degraded Adhesion Conditions." IEEE Transactions on Control Systems Technology 23, no. 1 (2015): 186–96. http://dx.doi.org/10.1109/tcst.2014.2320672.

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14

Conti, R., E. Meli, A. Ridolfi, and A. Rindi. "An innovative hardware in the loop architecture for the analysis of railway braking under degraded adhesion conditions through roller-rigs." Mechatronics 24, no. 2 (2014): 139–50. http://dx.doi.org/10.1016/j.mechatronics.2013.12.011.

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15

Choi, J. J., S. H. Park, and J. S. Kim. "Dynamic adhesion model and adaptive sliding mode brake control system for the railway rolling stocks." Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit 221, no. 3 (2007): 313–20. http://dx.doi.org/10.1243/09544097jrrt71.

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16

Nagase, K., Y. Wakabayashi, and H. Sakahara. "A study of the phenomenon of wheel climb derailment: Results of basic experiments using model bogies." Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit 216, no. 4 (2002): 237–47. http://dx.doi.org/10.1243/095440902321029190.

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Wheel climb derailment sometimes occurs when a train passes through a steep curve on a railway track at low speeds. The authors conducted experiments on the phenomenon of wheel climb derailment using model bogies and a model track. The Nadal formula (Nadal limit) is used to evaluate the risk of derailment. Because the friction coefficient between the rail and the wheel has a considerable influence on the critical values to be calculated using the Nadal formula, it is inappropriate to evaluate the risk of derailment by using the Nadal formula alone. The risk of derailment can be determined in a
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17

Barski, Dimitri, Holger Gerullis, Thorsten Ecke, et al. "Human Amniotic Membrane Is Not Suitable for the Grafting of Colon Lesions and Prevention of Adhesions in a Xenograft Rat Model." Surgical Innovation 24, no. 4 (2017): 313–20. http://dx.doi.org/10.1177/1553350617709828.

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Introduction. New biological materials are needed for specific applications in reconstructive bowel surgery and for the prevention of adhesion formation. Amniotic membranes (AMs) are assumed to have a number of unique characteristics that enhance the ingrowth of the surrounding tissue. The aim of the present study was to provide proof of these qualities in a xenograft model. Materials and methods. A multilayer human AM (HAM) was applied to repair defined colon wall defects in Sprague-Dawley rats (n = 18). The control group was repaired with a suture (n = 6). The animals were killed humanely at
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18

Borisov, Stanislav, Ekaterina Koltunova, and Sergei Kladiev. "Traction asynchronous electric drive of mine electric locomotivesimulation model structure improvement." Journal of Mining Institute 247 (March 16, 2021): 1–8. http://dx.doi.org/10.31897/pmi.2021.1.12.

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The article discusses the solution to the problem of underground railway transport slipping in dynamic modes, which occurs when there is a significant difference in the speeds of the driving and driven pairs of wheels. The state of the rail surfaces largely determines the coefficient of adhesion, therefore, using a mathematical model, the condition for the dependence of the magnitude of slipping and tractive effort is selected. For effective acceleration and deceleration of an electric locomotive, it is necessary to control the coefficient of adhesion at a certain level. A simulation model of
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19

Savos’kin, A. N., and N. D. Shilin. "Analysis of wheel pairs slip control of electric freight locomotive with asynchronous traction motors." RUSSIAN RAILWAY SCIENCE JOURNAL 81, no. 3 (2022): 230–39. http://dx.doi.org/10.21780/2223-9731-2022-81-3-230-239.

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Introduction. Every year, the amount of electric rolling stock with asynchronous traction motors is continuously increasing on the Russian railway network, since such traction drives have a number of advantages over drives with DC motors. One of the problems associated with the introduction of asynchronous motors and an increase in the mass of trains is the implementation of the maximum traction force by an electric locomotive at the threshold in terms of wheel – rail adhesion. Timely recognition of excessive slip of wheel pairs is the most important indicator of the efficiency of the traction
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20

Huang, Xuhui, Ciaron Hamilton, Zonglin Li, Lalita Udpa, Satish S. Udpa, and Yiming Deng. "Capacitive imaging for adhesive bonds and quality evaluation." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 378, no. 2182 (2020): 20190590. http://dx.doi.org/10.1098/rsta.2019.0590.

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Defective adhesive bonds pose significant threats towards structural integrity due to reduced joint strength. The nature of the adhesion of two solids remains poorly understood since the adhesion phenomenon is relevant to so many scientific and technological areas. A concept that has been gaining our attention from the perspective of non-destructive testing is the properties discontinuity of the adhesion. Discontinued properties depend significantly on the quality of the interface that is formed between adhesive and substrate. In this research, discontinued electrical properties at the interfa
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21

Lillehoj, E. P., S. W. Hyun, B. T. Kim, et al. "Muc1 mucins on the cell surface are adhesion sites forPseudomonas aeruginosa." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 1 (2001): L181—L187. http://dx.doi.org/10.1152/ajplung.2001.280.1.l181.

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Recently, we cloned and characterized a full-length cDNA of the hamster Muc1 gene, the expression of which appears to be associated with secretory cell differentiation (Park HR, Hyun SW, and Kim KC. Am J Respir Cell Mol Biol 15: 237–244, 1996). The role of Muc1 mucins in the airway, however, is unknown. In this study, we investigated whether cell surface mucins are adhesion sites for Pseudomonas aeruginosa. Chinese hamster ovary (CHO) cells not normally expressing Muc1 mucin were stably transfected with the hamster Muc1 cDNA, and binding to P. aeruginosa was examined. Our results showed that 1
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22

Conti, Roberto, Enrico Meli, Luca Pugi, et al. "A numerical model of a HIL scaled roller rig for simulation of wheel–rail degraded adhesion condition." Vehicle System Dynamics 50, no. 5 (2012): 775–804. http://dx.doi.org/10.1080/00423114.2011.640402.

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23

Meacci, Martina, Zhiyong Shi, Elisa Butini, Lorenzo Marini, Enrico Meli, and Andrea Rindi. "A local degraded adhesion model for creep forces evaluation: An approximate approach to the tangential contact problem." Wear 440-441 (December 2019): 203084. http://dx.doi.org/10.1016/j.wear.2019.203084.

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24

Bobo, S. N. "Fatigue Life of Aircraft Tires." Tire Science and Technology 16, no. 4 (1988): 208–22. http://dx.doi.org/10.2346/1.2148807.

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Abstract A study was conducted to determine if a safe upper service limit can be set for aircraft tires, based on an operation profile of the aircraft using the tires. The study consisted of three parts: development of a tire heating model, experimental confirmation, and determination of tire degradation as a function of time at temperature. Three operational profiles were identified: long, intermediate, and short haul; these stressed tires in different ways. The mathematical model, which calculated temperature as a function of time for various axial and lateral forces at different speeds, was
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25

Alturbeh, Hamid, Julian Stow, Gareth Tucker, and Alan Lawton. "Modelling and simulation of the train brake system in low adhesion conditions." Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit 234, no. 3 (2018): 301–20. http://dx.doi.org/10.1177/0954409718800579.

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This paper describes the current version of the Low Adhesion Braking Dynamic Optimisation for Rolling Stock (LABRADOR) simulation tool that can predict the train brake system performance and support decision-making in the design and optimisation of the braking system including wheel slide protection, sanders and the blending and control of friction and dynamic brakes in low adhesion conditions. The model has been developed in MATLAB/Simulink and is intended to mimic the braking performance of both older and newer generations of multiple unit passenger trains. LABRADOR models have been initiall
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26

Dybala, Vojtech, Martin Libensky, Bohumil Sulc, and Cyril Oswald. "Slip and Adhesion in a Railway Wheelset Simulink Model Proposed for Detection Driving Conditions Via Neural Networks." Transactions of the VŠB - Technical University of Ostrava, Mechanical Series 64, no. 1 (2018): 1–13. http://dx.doi.org/10.22223/tr.2018-1/2038.

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27

Ashaie, Maeirah, and Ezharul Hoque Chowdhury. "Nanoparticles-Facilitated Intracellular Transport of siRNAs against Individual Integrin Subunits Inhibits Growth of Breast Cancer Cells." Applied Sciences 11, no. 22 (2021): 10782. http://dx.doi.org/10.3390/app112210782.

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For cells and tissues, cell–cell and cell–extracellular matrix adhesion is important for proliferation, differentiation, and response to mechanical stimuli. This adhesion is provided by various cell adhesion molecules (CAMs). However, in breast cancer, depending upon the type and stage, this adherence is dysregulated where the expression of these cell adhesion molecules is either overregulated or unregulated, triggering essential oncogenic pathways. Thus, to control the invasiveness of tumor cells, and reduce metastasis, regulating the homophilic and heterophilic interaction of these molecules
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28

Suhr, Bettina, William A. Skipper, Roger Lewis, and Klaus Six. "Sanded Wheel–Rail Contacts: Experiments on Sand Crushing Behaviour." Lubricants 11, no. 2 (2023): 38. http://dx.doi.org/10.3390/lubricants11020038.

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In railway operation, the sanding process is used to overcome low adhesion conditions in the wheel–rail contact. In the literature, previously conducted research has been experimental, e.g., measuring adhesion coefficients (ACs) under different contact conditions (dry, wet, …) or applying different sands. Under dry conditions, sanding can reduce measured ACs, while under wet conditions different types of rail sand can leave ACs unchanged or increase adhesion. Despite active research, the physical mechanisms causing the change in ACs under sanded conditions are still poorly understood. A possib
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29

Arianna, Carpentieri, Cozzoli Eliana, Acri Flavio, et al. "Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds." Stem Cells International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2976541.

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Stem cells are a centerpiece of regenerative medicine research, and the recent development of adult stem cell-based therapy systems has vigorously expanded the scope and depth of this scientific field. The regeneration of damaged and/or degraded bone tissue in orthopedic, dental, or maxillofacial surgery is one of the main areas where stem cells and their regenerative potential could be used successfully, requiring tissue engineering solutions incorporating an ideal stem cell type paired with the correct mechanical support. Our contribution to this ongoing research provides a new model of in v
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30

Trimpe, Fritz, Sönke Lück, Rolf Naumann, and Corinna Salander. "Simulation of Torsional Vibration of Driven Railway Wheelsets Respecting the Drive Control Response on the Vibration Excitation in the Wheel-Rail Contact Point." Vibration 4, no. 1 (2020): 30–48. http://dx.doi.org/10.3390/vibration4010003.

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For the stability verification of railway wheelsets in Germany, dynamic torsional stresses must be respected as they affect the axle and press fit stability of a wheelset. These dynamic stresses are applied to a wheelset by torsional vibration. However, dynamic stresses cannot be predicted by calculation, and so time-consuming and cost-intensive test runs are performed to measure the maximum dynamic stresses. Therefore, this article deals with the setup of a simulation model that shall enable the simulative prediction of maximum dynamic torsional stresses. This model respects that vibration ex
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31

Dolatabadi, Nader, Ramin Rahmani, Stephanos Theodossiades, Homer Rahnejat, Guy Blundell, and Guillaume Bernard. "Tribodynamics of hydraulic actuated clutch system for engine-downsizing in heavy duty off-highway vehicles." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 233, no. 4 (2018): 976–93. http://dx.doi.org/10.1177/0954407018756789.

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Engine downsizing is desired for modern heavy-duty vehicles to enhance fuel economy and reduce emissions. However, the smaller engines usually cannot overcome the parasitic loads during engine start-up. A new clutch system is designed to disconnect the downsized engine from the parasitic losses prior to the idling speed. A multi-scale, multi-physics model is developed to study the clutch system. Multi-body dynamics is used to study the combined translational–rotational motions of the clutch components. A micro-scale contact model is incorporated to represent the frictional characteristics of t
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32

Kruchek, Victor, Aleksander Grishenko, and Tamila Tytova. "Utilization factor of adhesive weight of a locomotive with group tractive engine drive of wheelsets." Proceedings of Petersburg Transport University, no. 2 (June 20, 2017): 267–79. http://dx.doi.org/10.20295/1815-588x-2017-2-267-279.

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Objective: To improve accuracy of analytical calculation of adhesive weight of constructed and newly projected locomotives with wheelset group tractive drive. To bring out analytical dependence of a locomotive’s adhesive weight usage coefficient from a number of wheelsets in a group tractive engine considering constructive features of a vehicle, operating conditions and power equipment cycle of operation. Methods: Analytical dependences and a mathematical model were obtained on the basis of higher mathematics, laws of theoretical mechanics, reliability theory, probability theory, wheel-rail ad
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33

Tudorache, Cristina Mihaela, Razvan Andrei Oprea, and Cornelia Stan. "On the Simulation of Powered Axles Stick-Slip." Applied Mechanics and Materials 809-810 (November 2015): 610–15. http://dx.doi.org/10.4028/www.scientific.net/amm.809-810.610.

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The use of high power railway vehicles requires enhanced control of wheel-rail adherence. When setting the train in motion, driving axles can exhibit torsional vibrations resulting in poor adherence and even axle damage. A significant number of railway authorities safety warnings and accident reports were issued related to the above phenomena. Adhesion saturation and negative slope are the characteristics which lead to self-sustained axial vibration. The aim of the present work is to prove the appropriateness of non-smooth models in the study of the axle torsional stick-slip vibrations which m
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34

Hodivala-Dilke, Kairbaan, and Richard Hynes. "Insights and Questions Arising from Studies of a Mouse Model of Glanzmann Thrombasthenia." Thrombosis and Haemostasis 82, no. 08 (1999): 481–85. http://dx.doi.org/10.1055/s-0037-1615868.

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IntroductionStudies of patients suffering from Glanzmann thrombasthenia (GT) have provided many insights into the role of platelet adhesion in hemostasis and thrombosis,1-3 but they also have raised some unanswered questions. This genetically inherited bleeding disorder arises from mutations in the genes for either subunit of the major platelet integrin, αIIbβ3, or glycoprotein IIb/IIIa (CD41/CD61). These mutations lead to reduced or absent expression of this integrin on platelet surfaces or, in a few cases, to normal levels of expression of functionally defective forms of αIIbβ3.1-6 Normally,
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35

Rohwerder, M., and M. Stratmann. "Surface Modification by Ordered Monolayers: New Ways of Protecting Materials Against Corrosion." MRS Bulletin 24, no. 7 (1999): 43–47. http://dx.doi.org/10.1557/s0883769400052696.

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Metal/polymer composites are used in numerous technical applications. For example, polymer coatings on metal surfaces are used for corrosion protection, metal films on polymers inhibit static buildup, and polymers between two metals can serve as a “glue” for connecting materials that cannot be welded. Polymer/metal composites also play an important role in modern electronics. In condensers, polymers serve as insulating layers between metallic leads and are used to encapsulate entire electronic circuits. In all circumstances, interfaces are formed between the two different materials, and since
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36

Liu, Song, Jean Pierre Boutrand, and Marc Tadie. "Use of a collagen-based sealant to prevent in vivo epidural adhesions in an adult rat laminectomy model." Journal of Neurosurgery: Spine 94, no. 1 (2001): 61–67. http://dx.doi.org/10.3171/spi.2001.94.1.0061.

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Object. The authors investigated the effect of a collagen-based sealant, Gel Amidon Oxydé (GAO), in the prevention of epidural scar adhesions in an adult rat model of laminectomy. Methods. Seventy-two adult Sprague—Dawley rats underwent an L5–6 laminectomy, after which the dura mater and the left L-4 and L-5 nerve roots were exposed. In the 36 animals that received GAO, the sealant was applied over the dura and around the nerve roots, and it was used to fill the laminectomy cavity before it polymerized. In 36 control animals, the same surgical treatment was performed, but the rats did not rece
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37

Jin, Xuesong. "Research Progress of High-Speed Wheel–Rail Relationship." Lubricants 10, no. 10 (2022): 248. http://dx.doi.org/10.3390/lubricants10100248.

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The research on wheel–rail relationship includes the basic theoretical models and corresponding numerical methods of wheel–rail in rolling contact, geometric parameter matching and material matching of them, friction and wear, wheel–rail rolling contact fatigue, wheel–rail adhesion and noise. They are also key theoretical and technical problems of the high-speed train/track coupling system. The basic theoretical models of wheel–rail in rolling contact and the corresponding numerical methods are the basis and one of the basic means for solving other wheel–rail relationship problems. The other i
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38

Saleh, Omar A., Byoung-jin Jeon, and Tim Liedl. "Enzymatic degradation of liquid droplets of DNA is modulated near the phase boundary." Proceedings of the National Academy of Sciences 117, no. 28 (2020): 16160–66. http://dx.doi.org/10.1073/pnas.2001654117.

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Biomolecules can undergo liquid–liquid phase separation (LLPS), forming dense droplets that are increasingly understood to be important for cellular function. Analogous systems are studied as early-life compartmentalization mechanisms, for applications as protocells, or as drug-delivery vehicles. In many of these situations, interactions between the droplet and enzymatic solutes are important to achieve certain functions. To explore this, we carried out experiments in which a model LLPS system, formed from DNA “nanostar” particles, interacted with a DNA-cleaving restriction enzyme, SmaI, whose
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39

Qin, Yanghua, Yan Chen, and Qian Shen. "HMGB1-LPS complex promotes the transformation of SFs to a RASF-like phenotype (P4168)." Journal of Immunology 190, no. 1_Supplement (2013): 172.11. http://dx.doi.org/10.4049/jimmunol.190.supp.172.11.

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Abstract The specific pathogenesis of rheumatoid arthritis (RA) remains unclear. Current views hold that some inflammatory antigens recognize the Toll-like receptors on the synovial fibroblasts (SFs) and then activate downstream signals, leading to the formation of RASFs and the induction of RA. Our previous studies showed that intra-articular injection of the complex of HMGB1 and lipopolysaccharide (LPS) directly induced experimental arthritis in DBA/1 mice; histopathological analysis further revealed synovial thickening with excessive proliferation of SFs. In the present study, osteoarthriti
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40

Qin, Yanghua, Yan Chen, Weiwei Wang, et al. "HMGB1-PAMP complex promote the transformation of SFs to RASFs (171.19)." Journal of Immunology 188, no. 1_Supplement (2012): 171.19. http://dx.doi.org/10.4049/jimmunol.188.supp.171.19.

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Abstract The specific pathogenesis mechanism of rheumatoid arthritis (RA) remains unclear, current views believe the transformation of normal synovial fibroblasts (SFs) to RASFs is crucial for the pathogenesis of RA. Our previous studies showed that HMGB1-PAMP complex directly induced experimental arthritis in DBA/1 mice; pathology showed synovial thickening, and SFs excessive proliferation, suggesting that HMGB1-PAMP complex might induce the formation of RASFs. In current study, osteoarthritis synovial fibroblasts (OASFs) isolated from tissue obtained during reconstructive surgery and cocultu
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41

Mitchell, W. Beau, Marketa Jirouskova, JiHong Li та Barry S. Coller. "Differences in αIIbβ3 Biogenesis Dynamics between Umbilical Cord Blood-Derived Human Megakaryocyte-Like Cells and Transfected HEK293 Cells as Revealed by a Mathematical Model." Blood 104, № 11 (2004): 1559. http://dx.doi.org/10.1182/blood.v104.11.1559.1559.

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Abstract Most studies of αIIbβ3 biogenesis have been conducted in transfected HEK293 and CHO cells or megakaryocyte-like cell lines, but the protein processing mechanisms in native megakaryocytes may differ. To address this issue we have studied αIIbβ3 biogenesis in human megakaryocyte-like cells derived from umbilical cord blood (UCB) and in 293 cells stably expressing αIIbβ3, and developed a mathematical model to express the kinetics. The leukocyte pool of whole UCB units was separated by Dextran and Ficoll sedimentation and enriched for CD34+ progenitor cells by negative selection using a c
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42

Sawadkar, Prasad, Nandin Mandakhbayar, Kapil D. Patel, et al. "Three dimensional porous scaffolds derived from collagen, elastin and fibrin proteins orchestrate adipose tissue regeneration." Journal of Tissue Engineering 12 (January 2021): 204173142110192. http://dx.doi.org/10.1177/20417314211019238.

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Current gold standard to treat soft tissue injuries caused by trauma and pathological condition are autografts and off the shelf fillers, but they have inherent weaknesses like donor site morbidity, immuno-compatibility and graft failure. To overcome these limitations, tissue-engineered polymers are seeded with stem cells to improve the potential to restore tissue function. However, their interaction with native tissue is poorly understood so far. To study these interactions and improve outcomes, we have fabricated scaffolds from natural polymers (collagen, fibrin and elastin) by custom-design
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43

Gaide Chevronnay, Héloïse P., Christine Galant, Pascale Lemoine, Pierre J. Courtoy, Etienne Marbaix, and Patrick Henriet. "Spatiotemporal Coupling of Focal Extracellular Matrix Degradation and Reconstruction in the Menstrual Human Endometrium." Endocrinology 150, no. 11 (2009): 5094–105. http://dx.doi.org/10.1210/en.2009-0750.

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Coupling of focal degradation and renewal of the functional layer of menstrual endometrium is a key event of the female reproductive biology. The precise mechanisms by which the various endometrial cell populations control extracellular matrix (ECM) degradation in the functionalis while preserving the basalis and the respective contribution of basalis and functionalis in endometrium regeneration are still unclear. We therefore compared the transcriptome of stromal and glandular cells isolated by laser capture microdissection from the basalis as well as degraded and preserved areas of the funct
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44

Hügle, T., S. Nasi, D. Ehirchiou, P. Omoumi, A. So, and N. Busso. "POS0393 FIBRIN DEPOSITION IS AN ACTIVE TRIGGER OF CARTILAGE DEGENERATION IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 426.1–426. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2521.

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Background:Fibrin(ogen) maintains inflammation in various disorders but has never been linked to cartilage damage in rheumatoid arthritis (RA) or other forms of inflammatory arthritis.Objectives:To investigate the role of fibrin deposition on cartilage integrity in arthritis.Methods:Fibrin deposition on knee cartilage was analyzed by immunohistochemistry in RA patients and in murine adjuvant-induced arthritis (AIA). In chondrocytes, fibrinogen expression (Fgα, Fgβ, Fgγ) and procoagulant activity were evaluated by qRT-PCR and turbidimetry respectively. Fibrin-induced catabolic genes were assess
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45

Habanjar, Ola, Mona Diab-Assaf, Florence Caldefie-Chezet, and Laetitia Delort. "3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages." International Journal of Molecular Sciences 22, no. 22 (2021): 12200. http://dx.doi.org/10.3390/ijms222212200.

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The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long been used in cancer research. However, this system cannot be fully translated into clinical trials to ideally represent physiological conditions. This culture cannot mimic the natural tumor microenvironment due to the lack of cellular communication (cell-cell) and interaction (cell-cell and cell-matrix). To overcome these limitations, three-dimensional (3D) culture systems are increasingly developed in research and have become essential for tumor research, tissue engineering, and basic biology resear
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46

Stephenson, Diane, Tinggui Yin, E. Barry Smalstig, et al. "Transcription Factor Nuclear Factor-Kappa B is Activated in Neurons after Focal Cerebral Ischemia." Journal of Cerebral Blood Flow & Metabolism 20, no. 3 (2000): 592–603. http://dx.doi.org/10.1097/00004647-200003000-00017.

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Nuclear factor-kappa B (NF-kB) is a multisubunit transcription factor that when activated induces the expression of genes encoding acute-phase proteins, cell adhesion molecules, cell surface receptors, and cytokines. NF-kB is composed of a variety of protein subunits of which p50-and p65-kDa (RelA) are the most widely studied. Under resting conditions, these subunits reside in the cytoplasm as an inactive complex bound by inhibitor proteins, IkBα and IkBβ. On activation, IkB is phosphorylated by IkB kinase and ubiquitinated and degraded by the proteasome; simultaneously, the active heterodimer
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47

Elg, Margareta, and Helen Zachrisson. "Effect of AR-H067637, the Active Metabolite of the Oral Anticoagulant AZD0837, on Thrombus Formation Using Human Whole Blood in an In Vitro Flow Chamber Model." Blood 112, no. 11 (2008): 4049. http://dx.doi.org/10.1182/blood.v112.11.4049.4049.

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Abstract AR-H067637 is a direct thrombin inhibitor derived in vivo from the orally available prodrug AZD0837. AR-H067637 is a reversible and selective direct thrombin inhibitor, which has an inhibition constant, Ki, of 2–4 nmol/L against human alpha-thrombin. During early development of a new anticoagulant drug, data on antithrombotic doses from animal studies may help guide selection of the dose to use in initial human studies. In the present study, using a flow chamber model developed by Badimon and colleagues (Badimon L, et al. J Lab Clin Med1987;110:706–718), the antithrombotic effect of A
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48

Pallis, Flavia Rubia, Camila Bononi Almeida, Marcus Corat, et al. "Rho-Kinase Inhibition Attenuates Airway Inflammation In An Experimental Asthma Model In Sickle Cell Mice." Blood 122, no. 21 (2013): 731. http://dx.doi.org/10.1182/blood.v122.21.731.731.

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Abstract Introduction Asthma in sickle cell disease is known to be associated with increased morbidity and an elevated rate of sickle cell complications, such as acute chest syndrome, stroke, vaso-occlusive episodes and early mortality. Experimental asthma increases eosinophil and collagen deposition in the lungs of SCD mice, induces profound increases in pulmonary inflammation, shifts in TH1 and TH2 cytokine production, and airway resistance. A small GTPase, Rho, and its target molecule, Rho-kinase (ROCK), play an important role in cell functions, including contractility, chemotaxis, adhesion
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49

Keleku-Lukwete, Nadine, Mikiko Suzuki, Akihito Otsuki, et al. "Keap1-Nrf2 System: Potential Role in Prevention of Sickle Cell Disease Organs Damages and Inflammation." Blood 126, no. 23 (2015): 411. http://dx.doi.org/10.1182/blood.v126.23.411.411.

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Abstract Chronic hemolysis in sickle cell disease (SCD) gives rise to intermittent vessel occlusion. Recurrent ischemia-reperfusion generates high levels of reactive oxygen species (ROS) that leads to cell damage. On the other hand, lysed red blood cells (RBC) released free heme into blood stream, which contributes to generation of oxidant microenvironment. ROS burden generated by heme and ischemia-reperfusion injury contributes to endothelial cell activation that promotes inflammatory response with activation of inflammatory mediators. Sickle cell patients bearing high white blood cell (WBC)
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50

Schneider, Gabriela, Kim ChiHwa, Ahmed Abdel-Latif, Anna Janowska-Wieczorek, Janina Ratajczak, and Mariusz Z. Ratajczak. "A Novel Perspective On Hematopoietic Stem/Progenitor Cell Homing - an Expanding Family of Bone Marrow Homing Factors That Can Support SDF-1-Mediated Homing or Even Replace SDF-1." Blood 120, no. 21 (2012): 1247. http://dx.doi.org/10.1182/blood.v120.21.1247.1247.

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Abstract Abstract 1247 Background. Hematopoietic stem progenitor cells (HSPCs) are retained in bone marrow (BM) niches due to the stromal-derived growth factor-1 (SDF-1)–CXCR4 receptor axis and interactions between Very Late Antigen-4 (VLA-4, also known as α 4β1integrin) and its ligand, Vascular Adhesion Molecule-1 (VCAM-1 or CD106). While HSPCs express CXCR4 and VLA-4, their corresponding ligands, SDF-1 and VCAM-1, are expressed by cells in the BM microenvironment (e.g., osteoblasts and fibroblasts). While a role for the SDF-1–CXCR4 axis in the retention of HSPCs in BM under steady-state cond
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