Relevant bibliographies by topics / Radiographie bi-Plane faible dose

Academic literature on the topic 'Radiographie bi-Plane faible dose'

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Published: 7 July 2024
Last updated: 7 July 2024

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  1. Journal articles
  2. Dissertations / Theses

Journal articles on the topic "Radiographie bi-Plane faible dose":

1

DePhillipo, Nicholas N., Andrew S. Bernhardson, Zachary S. Aman, Mitchell Kennedy, Grant Dornan, and Robert F. LaPrade. "Decreased Posterior Tibial Slope Does Not Impact Postoperative Posterior Knee Laxity after Double-Bundle Posterior Cruciate Ligament Reconstruction." Orthopaedic Journal of Sports Medicine 7, no. 7_suppl5 (July 2019): 2325967119S0030. http://dx.doi.org/10.1177/2325967119s00301.

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Objectives: Recent clinical studies have identified sagittal plane posterior tibial slope as a risk factor for increased postoperative laxity after single-bundle (SB) posterior cruciate ligament reconstruction (PCLR). However, the effect of tibial slope and its role in graft laxity following double-bundle (DB) PCLR has not been investigated clinically. Therefore, the purpose of this study was to retrospectively compare the degree of posterior tibial slope and its impact on posterior tibial translation (PTT) after DB PCLR. It was hypothesized that preoperative tibial slope would not be associated with graft laxity following DB PCLR. Methods: Patients who underwent primary DB PCLR without ACL injury between 2010 and 2017 by a single surgeon were retrospectively analyzed. Measurements of posterior tibial slope were performed using the lateral radiograph and PTT was measured using kneeling PCL stress radiographs, preoperatively and at a minimum of 1-year postoperatively. Linear regression was used to assess the relationship between native posterior tibial slope and postoperative graft laxity, determined by PCL stress radiographs. Results: One hundred three patients with PCL tears and subsequent DB PCL reconstructions were included. Ninety (87.4%) patients reported a contact mechanism at time of injury, while 13 (12.6%) patients reported a noncontact injury mechanism. Sixty-four (62.1%) patients had combined extra-articular ligament injuries that were concurrently reconstructed with the PCL tear, while isolated PCL tears were identified in 39 (37.9%) patients. Forty-nine (47.6%) patients had an acute (less than 6 weeks) injury, 54 (52.4%) patients had a chronic (greater than 6 weeks) injury at time of imaging and evaluation. Four (4%) patients demonstrated failed PCLRs, as defined by SSD in PTT greater than 8 mm on PCL stress radiographs. The mean posterior tibial slope for all PCL injured patients was 5.9 degrees &#177; 2.2 degrees. There was a significant reduction in the amount of mean SSD in PTT between preoperative (10.6 &#177; .7 mm) and postoperative (1.5 &#177; 2.6 mm) PCL stress radiographs following DB PCLR (95% CI [8.4, 9.8], p < 0.001). Linear regression analysis revealed no significant correlation between preoperative posterior tibial slope and the amount of SSD in PTT on postoperative stress radiographs obtained at a mean 18.5 months postoperatively (R = -0.115, p = 0.249). Similarly, when adjusting for combined ligamentous injury, injury chronicity, mechanism of injury, BMI, and age at surgery via multiple linear regression, preoperative tibial slope was not a significant independent predictor of postoperative SSD in PTT (beta = -0.079, 95% CI [-0.308, 0.150], p = 0.496). Combined injury (beta = -1.01, 95% CI [-2.00, -0.01], p = 0.047) was a significant independent predictor of decreased postoperative SSD in PTT on posterior stress radiographs. Conclusion: Graft laxity, determined by PTT in posterior kneeling stress radiographs, was not influenced by decreased posterior tibial slope in patients following DB PCLRs. Combined PCL injury was a significant independent predictor of decreased postoperative SSD in PTT on posterior stress radiographs. Additionally, the majority of patients (96%) demonstrated improved objective posterior knee stability following DB PCLR. Thus, DB PCLR can be recommended as a surgical treatment option for patients with grade III isolated and combined PCL injuries, irrespective of native posterior tibial slope. [Table: see text]
2

Fontana, Elisa, Babar Bashir, Judy S. Wang, Raid Aljumaily, Jean-Pascal Machiels, Maria Vieito, Gerald Falchook, et al. "Abstract LB_A17: Trial in progress: First-in-human phase I dose-escalation study of a novel Bicycle toxin conjugate (BT5528) targeting EphA2 in patients with advanced solid tumors." Molecular Cancer Therapeutics 22, no. 12_Supplement (December 1, 2023): LB_A17. http://dx.doi.org/10.1158/1535-7163.targ-23-lb_a17.

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Abstract Background: Bicycles are a novel class of synthetic molecules formed by short linear peptides constrained in a stabilized bi-cyclic structure that can be conjugated to other molecules. BT5528 is a Bicycle Toxin Conjugate, comprising a bicyclic peptide targeting EphA2 linked to a cytotoxin (monomethyl auristatin E [MMAE]). EphA2 is expressed at low levels in normal tissues but overexpressed in many solid tumors; EphA2 expression correlates with malignant progression and poor patient outcome. BT5528 is ~40X smaller than antibody-drug conjugates (ADCs) and has the potential to penetrate solid tumors. Within the tumor, release of MMAE disrupts intracellular microtubule dynamics leading to inhibited proliferation and tumor cell death with bystander killing effect. The pharmacokinetic (PK) profile of BT5528 is distinct from ADCs with lack of Fc-mediated non-specific uptake, fast distribution, and renal elimination, leading to lower vascular exposure and potentially reduced toxicity in non-target tissues. The preclinical profile supported the initiation of a first-in-human study to investigate BT5528 safety and efficacy in advanced solid tumors with EphA2 expression (NCT04180371). Methods: This phase 1/2 multicenter, open-label trial evaluates BT5528 as monotherapy and in combination with nivolumab (nivo) in up to 288 patients. Phase 1 employs a 3+3 dose-escalation design for the first two dose levels followed by a Bayesian logistic regression model. Phase 2 expansion will test the selected dose(s) of BT5528 in six tumor-specific cohorts with high EphA2 expression (NSCLC, ovarian, TNBC, gastric/upper GI, head and neck, and urothelial cancer). BT5528 will be administered intravenously (IV) in ascending doses either weekly or every other week as monotherapy in Part A-1 and in combination with nivo in Part A-2 (480 mg of IV nivo every 4 weeks or 240 mg every 2 weeks), and as per the recommended phase 2 dose(s) (RP2D) in Part B. Part A patients must have a metastatic solid tumor type known to have high EphA2 tumor expression and Part B patients must have one of the specified tumor types; all patients must have failed or be ineligible for appropriate treatment options with evidence of radiographic progression on the most recent line of therapy. Additional eligibility criteria include ≥18 years of age, ECOG performance status of 0 or 1, and adequate organ function. Primary objectives for Part A are safety and tolerability and to define the maximum tolerated dose (if observed) and RP2D(s) as monotherapy and in combination with nivo. The primary objective for Part B is to assess clinical activity of BT5528 monotherapy. Secondary objectives include preliminary efficacy (Part A), safety and tolerability (Part B), correlation of EphA2 expression with efficacy (Part B), PK parameters of BT5528 and MMAE, and incidence of anti-drug antibodies. Tumor and blood samples will be collected for biomarker evaluations including tumor EphA2 expression, ADAs, and candidate response biomarkers for BT5528 alone and in combination with nivo. This study is actively recruiting. Citation Format: Elisa Fontana, Babar Bashir, Judy S. Wang, Raid Aljumaily, Jean-Pascal Machiels, Maria Vieito, Gerald Falchook, Louise Carter, Bernard Doger de Spéville, Alastair Greystoke, Sang Wun Kim, Nuria Kotecki, Alexander I. Spira, Irene Moreno Candilejo, Bristi Basu, Hans Prenen, Alberto Bessudo, Misako Nagasaka, Jordi Rodón Ahnert, Joo-Hwan Park, Min-Yuen Teo, Julia Rotow, Jie Liu, Assunta De Rienzo, Mengyao Li, Adriana Domingo, Hanna Orr, Gavin Bennett, Rajiv Sharma, Meredith McKean. Trial in progress: First-in-human phase I dose-escalation study of a novel Bicycle toxin conjugate (BT5528) targeting EphA2 in patients with advanced solid tumors [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr LB_A17.
3

Bailey, Chris, Alexandra Stratton, Neil Manson, Elliot Layne, Melissa McKeon, Simon Harris, Greg McIntosh, et al. "Canadian Spine Society01.1.1: Surgery versus standardized nonoperative care for the treatment of lumbar disc herniations: a Canadian trial02.1.1: Wait times for elective spine surgery across Canada: data from the Canadian Spine Outcomes and Research Network03.1.1: Presurgical physician utilization in elective thoracolumbar spine surgery candidates: a nationwide analysis from the CSORN database04.1.2: Activities performed and treatments conducted prior to consultation with a spine surgeon: Are patients and clinicians following evidence-based clinical practice guidelines?05.1.2: Patient-reported disability versus objective physical performance measures in assessing patient recovery06.1.2: Risk factors for work status in low back pain patients: a cross-sectional analysis of patients presenting to the Ontario Inter-professional Spine Assessment and Education Clinics07.1.3: Comparison of symptomatic, functional and demographic characteristics of postsurgical versus nonoperative LBP patients08.1.3: Are primary care patients with different patterns of low back pain epidemiologically distinct?09.1.3: Lack of prognostic model validation in low back pain prediction studies10.1.4: Larger scoliosis curve magnitude is associated with increased surgical and perioperative complications: a multi-centre analysis of 1173 adolescent idiopathic scoliosis curves11.1.4: Superior extension of upper instrumented level in distraction-based surgery: a surrogate for clinically significant PJK12.1.4: The optimal surgical approach for Lenke 5 curves: Is the anterior approach ready for a comeback?13.1.5: Improving quality and safety in pediatric spine surgery: the team approach14.1.5: Posterior vertebral column resection in pediatric deformity: the advantages of staging15.1.5: Minimally invasive surgery in adolescent idiopathic scoliosis: lessons learned at mean 2-year follow-up16.2.1: Development of a Canadian competency-based spine surgery fellowship education curriculum17.2.1: Computer-assisted surgery is an effective educational tool for the training of orthopedic surgery residents in pedicle screw placement18.2.1: Validation of the Calgary Spine Severity Score19.2.2: Can triaging referrals with a simple 3-item pain questionnaire reduce wait times for consultations for patients who would benefit from lumbar spinal surgery?20.2.2: Strategies to improve the credibility of meta-analyses in spine surgery: a systematic survey21.2.2: The societal cost of waiting to see a spine surgeon for lower back symptoms in Canada22.2.3: The cost of an adverse event depends on its definition and method of capture23.2.3: Economic evaluation of intraoperative cone beam CT-based navigation for the placement of spinal pedicle screws: a patient-level cost-effectiveness analysis24.2.3: Predictors of inappropriate emergency department utilization following elective thoracolumbar spine surgery25.2.4: Incidence, impact and risk factors of adverse events in thoracic and lumbar spine fractures. An ambispective cohort analysis of 390 patients26.2.4: Factors associated with adverse events in major elective spine, knee, and hip in-patient orthopedic surgery27.2.4: Prognostic factors for survival in surgical series of symptomatic metastatic epidural spinal cord compression: a prospective North American multicentre study in 142 patients28.2.5: A comparison of 2 prospective adverse event recording tools with institutional ICD-10 coding for detecting perioperative adverse events in patients undergoing spinal surgery29.2.5: Assessment of impact of long-cassette standing radiographs on surgical planning for lumbar pathology: an international survey of spine surgeons30.2.5: Long-term patient-reported outcome and surgical survivorship of MIS fusion for low-grade spondylolisthesis31.3.1: The effect of prolonged postoperative antibiotic administration on the rate of infection in patients undergoing posterior spine surgery requiring a Hemovac drain32.3.1: Preliminary results of a Phase 1 trial on the use of photodynamic therapy in vertebral metastases33.3.1: The minimal clinically important difference of the modified Japanese Orthopaedic Association score in patients with degenerative cervical myelopathy undergoing surgical intervention34.3.1: Patient and surgeon radiation exposure during spinal instrumentation using intraoperative CT-based navigation35.3.2: Are postoperative pelvic parameters and sagittal balance predictive of further lumbar surgery in patients with spinal stenosis?36.3.2: Postoperative ambulation in patients undergoing total hip arthroplasty, total knee arthroplasty and elective lumbar spine surgery to treat arthritic pathologies37.3.2 Pain on the brain: Is the SF-36 mental component summary enough?38.3.2: Accurate and safe cervical osteotomy for kyphotic deformity in ankylosing spondylitis39.3.3: Adjacent segment pathology in the lumbar spine: progressive disease or a consequence of iatrogenic fusion?40.3.3: The association of cervical spine alignment with neurological recovery in a prospective cohort of surgical myelopathy patients: analysis of a series of 124 cases41.3.3: Use of neuropathic pain questionnaires in predicting the development of failed back surgery syndrome following lumbar discectomy for radiculopathy42.3.3: Quality of life and neurological outcomes after surgical decompression in patients with cervical ossification of the posterior longitudinal ligament: prospective, multicentre AOSpine International study of 479 patients43.3.4: Minimally invasive decompression in focal lumbar spinal stenosis with or without stable spondylolisthesis — comparative outcomes and reoperation rates at a minimum of 2 years44.3.4: Impact of nonoperative care utilization on postthoracolumbar spine surgery outcomes: a national perspective using the CSORN registry45.3.4: Presurgical imaging, testing and injection utilization in elective thoracolumbar spine surgery candidates: a nationwide analysis from the CSORN database46.3.5: A clinical prediction rule for clinical outcomes in patients undergoing surgery for degenerative cervical myelopathy: analysis of an international AOSpine prospective multi-centre dataset of 743 patients47.3.5: A comparison of health-related quality of life outcomes in spinal cord injury patients residing in rural and urban areas48.3.5: Minimally invasive versus open discectomy: a systematic review and meta-analysis49.1.1: Validity of transcranial motor evoked potentials as early indicators of neural compromise in rat model of spinal cord compression50.1.2: Validation of true spine length radiographic measurements51.1.3: Closure of the intervertebral disc annulus fibrosus using a novel suture application device — in vivo porcine and ex vivo biomechanical evaluation52.1.4: Vertebroplasty versus kyphoplasty in osteoporotic vertebral compression fracture model: What is safer?53.1.5: Brain-derived neurotrophic factor promotes intraneural macrophage migration and allodynia in experimental disc-herniation neuropathy54.1.6: Development and evaluation of an open-source 3D virtual simulator with integrated motion-tracking as a teaching tool for pedicle screw insertion55.2.7: Preoperative “amber flag” psychological measure scores and patient expectations: a nationwide analysis from the CSORN database56.2.8: Assessment of frailty in elderly spinal surgery patients57.2.9: Predicting adverse events and their impact on hospital length of stay in a prospective Spine AdVerse Events Severity (SAVES) database58.2.10: Clinical and surgical predictors of perioperative complications in patients with degenerative cervical myelopathy: results from the multicentre, prospective AOSpine International study on 479 patients59.2.11: Longitudinal analysis of the incidence of adverse events in tertiary spine referral centres: a national perspective from the Canadian Spine Outcomes and Research Network (CSORN) registry60.2.12: The use of validated clinical outcome measures in spinal surgery: an analysis of recent annual meeting abstracts61.1.13: The efficacy and accuracy of cone beam CT (O-Arm) navigation (StealthStation) on screw position in primary cases of adult major deformity surgery62.1.14: Does early surgical decompression improve neurological recovery of complete spinal cord injury? A prospective cohort study63.1.15: The role of MRI in predicting surgical outcome in patients with degenerative cervical myelopathy64.1.16: Postsurgical patients can have similar functional improvements and return to work rates following rehabilitation as those treated nonsurgically65.1.17: Intraoperative cone beam CT (O-Arm) and stereotactic navigation (StealthStation) system in complex adult spine surgery — early experience and learning curve66.1.18: A pilot randomized controlled trial of iodine-impregnated plastic adhesive drape usage in spine surgery and the effect on wound bacterial load67.2.19: Dynesys long-term outcome study68.2.20: Maverick total disc replacement in a real-world patient population: a prospective, multicentre observational study69.2.21: Pedicle screw malposition in revision spinal surgery: efficacy of intraoperative CT-based navigation70.2.22: Intraoperative skull-femoral traction in posterior spinal arthrodesis for adolescent idiopathic scoliosis: the impact on perioperative outcomes and health resource utilization71.2.23: The effect of growth-friendly surgery on coronal and sagittal plane spine growth in idiopathic scoliosis72.2.24: A qualitative web-based expert opinion analysis on the adoption of intraoperative CT and navigation systems in spine surgery." Canadian Journal of Surgery 58, no. 3 Suppl 1 (June 2015): S43—S70. http://dx.doi.org/10.1503/cjs.005515.

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Dissertations / Theses on the topic "Radiographie bi-Plane faible dose":

1

Loisel, François. "Analyse cinématique et biomécanique de la main et du poignet par modélisation personnalisée. Effet de lésions et d’instrumentations." Electronic Thesis or Diss., Paris, HESAM, 2023. http://www.theses.fr/2023HESAE097.

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L’architecture de la main et du poignet est un ensemble complexe d’articulations permettant la réalisation efficace de l’ensemble des gestes de la vie quotidienne.La précision des mouvements et la transmission des forces effectrices nécessitent une congruence articulaire optimale et une cohésion osseuse assurées par un système ligamentaire organisé.Tout traumatisme engendrant un écart articulaire (fracture) ou une perte de la cohésion osseuse (rupture ligamentaire) risque de produire des mouvements pathologiques au sein de ces articulations. Il apparaît alors des douleurs, une diminution des amplitudes de mouvements et une altération de la fonction globale. La connaissance des mécanismes physiopathologiques conduisant à ces troubles est essentielle à plusieurs niveaux : premièrement, dans un cadre diagnostic, pour pouvoir identifier une éventuelle lésion, même partielle, et la traiter ; deuxièmement, dans un cadre d’amélioration de la connaissance globale de la cinématique physiologique et pathologique de la main et du poignet ; et enfin, dans un cadre d’innovation afin de proposer de nouvelles solutions (implants) à des problèmes non résolus.La conception de modèles géométriques et biomécaniques personnalisés dans le contexte général de l’étude des articulations humaines permet de répondre à ce type de questions. Dans un travail préliminaire, lié à mon master recherche et à la thèse de Stan Durand, des essais biomécaniques ont été réalisés sur pièces anatomiques pour analyser l’effet d’un implant spécifique sur le comportement cinématique du poignet et concevoir une méthode de modélisation personnalisée de la main et du poignet par l’acquisition de radiographies biplanes faibles doses.Dans la continuité de ce projet, ce travail de thèse présente plusieurs objectifs.Le premier objectif est de valider notre méthode de modélisation de la main et du poignet personnalisée chez le vivant, en comparant cette méthode à la technique de référence de segmentation scannographique.Le deuxième objectif est d’appliquer cette méthode pour constituer un corridor de déplacement physiologique de certains os d’intérêt du carpe (scaphoïde, lunatum, triquétrum), entre deux positions de référence (poignet en position neutre ou poing fermé) parmi une population de volontaires indemnes de lésions ligamentaires. Ce corridor de normalité est utile pour comparer les déplacements physiologiques et pathologiques en pratique clinique.Le troisième objectif est de comparer les données de cinématiques carpiennes de patients atteints de lésions ligamentaires infra radiologique à ce corridor de normalité. Le but est d’évaluer les capacités diagnostic du modèle personnalisé. En analysant les données pré et post opératoire, une étude de faisabilité permet en outre d’investiguer le champ du suivi objectif de la restauration chirurgicale par suture ou réancrage ligamentaire.La finalité générale d’une telle étude est donc l’utilisation de modèles géométriques, cinématiques et biomécaniques de la main et du poignet dans le but d’évaluer la cinématique normale et pathologique (diagnostic) et d’analyser des implants chirurgicaux actuels afin de proposer des axes d’amélioration
The architecture of the hand and wrist is a complex set of articulations enabling the efficient execution of all the gestures of daily life.Precision of movement and transmission of effector forces require optimal joint congruence and bone cohesion ensured by an organized ligament system.Any trauma resulting in articular step off (fracture) or loss of bone cohesion (ligament rupture) is likely to produce pathological kinematics within these joints. The result is pain, decrease range of motion and impaired overall function. Knowledge of the pathophysiological mechanisms leading to these disorders is essential on several levels: firstly, in a diagnostic context, to be able to identify and treat any injury, even a partial one. Secondly, to improve overall knowledge of the physiological and pathological kinematics of the hand and wrist. And lastly, as part of an innovation drive to propose new solutions (implants) to unresolved problems.The design of customized geometric and biomechanical models in the general context of the study of human joints provides answers to these types of questions. In preliminary work, linked to my Master's research and Stan Durand's thesis, biomechanical tests were carried out on anatomical parts to analyze the effect of a specific implant on the kinematic behavior of the wrist, and to design a method for personalized modeling of the hand and wrist using low-dose biplane X-rays.Following on from this project, this thesis has several objectives.The first objective is to validate our method of personalized hand and wrist modeling in living subjects, by comparing it with the reference technique of TDM segmentation.Secondly, we will apply this method to create a corridor of physiological displacement of certain carpal bones of interest (scaphoid, lunate, triquetrum), between two reference positions (wrist in neutral position or closed fist) among a population of volunteers free of ligament lesions. This corridor of normality is useful for comparing physiological and pathological displacements in clinical practice.Indeed, the third objective is to compare carpal kinematic data from patients with infra-radiological ligament lesions with this corridor of normality. The aim is to assess the diagnostic capabilities of the customized model. By analyzing pre- and post-operative data, a feasibility study will also investigate the field of objective follow-up of surgical restoration by suture or ligament re-anchoring.The aim of such a study is therefore to use geometric, kinematic and biomechanical models of the hand and wrist to assess normal and pathological kinematics (diagnosis), and to analyze current surgical implants in order to propose areas for improvement
2

Jerbi, Taha. "Recalage de structures tridimensionnelles à partir d'acquisitions stéréo-radiographiques basse dose. Application à l'estimation de mouvements humains." Phd thesis, 2012. http://tel.archives-ouvertes.fr/tel-00719664.

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Les maladies ostéoarticulaires constituent une part importante des pathologies qui touchent l'appareil locomoteur humain et elles ont un impact majeur quant à l'individu et à la société. Dans ce cadre les études cinématiques présentent un outil permettant aux cliniciens une évaluation de l'état des articulations. Ces études passent par une estimation du mouvement des structures osseuses. Plusieurs approches sont actuellement utilisées dans cet objectif : passant par le suivi de marqueurs externes (fixés sur la peau), internes (fixés sur les os), la palpation, et le recalage d'images médicales (radiographies, CT, IRM). Cette dernière approche a été retenue en proposant un recalage 2D 3D pour l'estimation des positions des structures osseuses. Dans une première partie, on tire profit de la particularité d'une nouvelle modalité radiologique bi-planes basse dose (EOS) pour proposer une méthode originale et particulièrement bien adaptée et qui utilise le théorème classique de la coupe centrale de Fourier. Pour cela, dans un premier temps, au travers d'un état de l'art des approches classiques de l'estimation de mouvements, nous réalisons une classification originale multi critères (invasivité, précision, généricité) afin de bien situer les apports de cette nouvelle modalité. Dans un deuxième temps, nous proposons une alternative au schéma classique de recalage 2D 3D qui présente plusieurs avantages. Le recalage effectué dans le domaine fréquentiel établit un lien élégant entre les données 2D et 3D ce qui permet d'éviter la simulation des radiographies. La recherche des deux composantes du mouvement rigide, rotation et translation, est effectuée d'une manière séquentielle. D'abord, la rotation est déterminée par une optimisation itérative d'une métrique dépendant des modules des données. La translation se déduit, alors, directement en utilisant les phases. Une deuxième partie est consacré à la mise en oeuvre pratique de la méthode et à l'évaluation de l'implémentation sur des données de plus en plus complexes allant des données synthétiques, des fantômes puis des données EOS réelles composées de radiographies frontales et sagittales et d'une seule reconstruction 3D. Ceci permet de valider la méthode dans des conditions réelles d'acquisition. L'application de notre méthode de recalage pour l'estimation de mouvement de différentes structures : fémur, tibia, prothèses de genou et de hanche, nous a permis d'illustrer la généricité de l'approche proposée.

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