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Dissertations / Theses on the topic 'Radioactive tracers in physiology'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Duncan, Henry J. "An isotope washout technique to study skin perfusion pressure and vascular resistance in diabetes, hypertension and peripheral vascular disease /." Cover title, title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09MD/09mdd911.pdf.

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2

Stephenson, Karin A. Valliant John Fitzmaurice. "New approaches for the preparation of peptide-targeted radiotracers." *McMaster only, 2005.

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3

Altomonte, Stefano. "Cannabinoid receptor subtype-1 (CB1) ligands : synthesis and brain PET imaging with 11C and 18F radiotracers." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=214832.

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4

Sognstrup, Larsen Uffe. "New methods for simple and selective tritium labelling of drug candidates & synthetic studies towards crisamicin A /." Cph. : Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences : Department of Isotope Chemistry, Novo Nordisk A/S, 2005. http://www.dfh.dk/phd/defences/UffeSognstrupLarsen.htm.

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5

Riddoch, Robert William Valliant John Fitzmaurice. "Solid-phase synthesis of radiotracers /." *McMaster only, 2004.

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6

Olshen, Adam B. "Modeling PET blood curves /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9530.

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7

Musolino, Manuele. "Development and use of [18F]FDR as a new powerful radiolabelling agent for Positron Emission Tomography (PET) imaging of hypoxia." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232411.

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In recent years tumour hypoxia has been extensively investigated, mainly because it is a source of resistance to the common radio and chemo therapies. In fact, the low levels and heterogeneous distribution of oxygen in hypoxic microenvironment render ionizing radiation ineffective in treating cell proliferation. Furthermore, a low oxygen concentration promotes the activation of HIF-1 transcription factor, which favours the development of a more malignant and resistant cancer cell phenotype often associated with poor prognosis. Positron Emission Tomography (PET) imaging is a valuable diagnostic

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8

Blais, Jean-Simon. "Determination of alkyllead compounds and synthesis of alkyllead radiotracers." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66177.

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9

Woodbury, Julie L. (Julie Lynn). "Internal Radiolabeling of Mycobacterial Antigens and Use in Macrophage Processing Studies." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc500936/.

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Mycobacter avium complex serovars 4 and 20 were cultured in the presence of [3H] fucose, [3H]-methionine, and [3H]-mannose to specifically radiolabel the oligosaccharide of the glycopeptidolipid (GPL) antigens. Distribution of radioactivity in lipid was determined by thin-layer chromatographic methods. Examination of acid hydrolysates from radiolabeled antigens revealed that [3H]-methionine incorporated into methylated sugars in polar and apolar GPL components, whereas [3H]-mannose incorporated exclusively into the oligosaccharide of polar GPL antigens. Least incorporation of radiolabel into a

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10

DeTurk, Kenneth Wayne. "Optimum ¹¹¹In okine labelled autologous leukocytes." Scholarly Commons, 1989. https://scholarlycommons.pacific.edu/uop_etds/2187.

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The purpose of this study is to determine the optimum conditions for obtaining a leukocyte button which most effectively will be subsequently labelled with 111In oxine. As in all radiopharmaceuticals, the highest radiopharmaceutical purity, or the fraction of total radioactivity in the desired radiopharmaceutical form (111In oxine leukocyte), the better the product. Many 111In ocine labelled leukocytes are contaminated by labelled platelets, red cells, and proteins, resulting in a “dirty” product. But with careful leukocyte culturing, sedimentation, centrifugation, and labelling, as demonstrat

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11

Stroup, Laurie B. "Radioactive pyruvate oxidation and the effects of fatty acid inhibition in the aging rat." Virtual Press, 1989. http://liblink.bsu.edu/uhtbin/catkey/560276.

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To investigate the possible changes in pyruvate oxidation during the rapid growth period in an animal model, the oxidation of radioactive labeled pyruvate was measured in mitochondria isolated from the gastrocnemius muscle of Sprague--Dawley rats between 4 and 16 weeks of age. The influence of the fatty acid derivative palmitylcarnitine, as an inhibitor of pyruvate oxidation, was also tested.The gastrocnemius muscle was removed from anesthesized animals at 4, 8 and 16 weeks of age. Isolated mitochondria from the muscle samples were incubated with C1--14C] pyruvate and E1-14C] pyruvate + palmit

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12

Crane, Justin D. "The muscle specific protein synthesis response to acute running exercise utilizing multiple stable isotope tracers." Virtual Press, 2008. http://liblink.bsu.edu/uhtbin/catkey/1398709.

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The purpose of this study was to compare the anabolic response to acute running exercise in two different leg muscles in endurance-trained men using two different stable isotope tracers. 6 male subjects (26±2 yr; V02max 63±2 ml•kg-' •min-') performed a 45 min treadmill run at 77±1 % intensity. Infusions of d3-leucine and d5-phenylalanine were used to measure mixed muscle FSR at rest and 24 hr post-exercise. An additional infusion of 10% amino acid solution was added to the post-exercise infusion to maximize the muscle anabolic response. Muscle biopsies were obtained from the vastus lateralis (

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13

Pawlisz, Andrew V. "Internal residues of the narcotic organic chemicals in the Cladoceran, Daphnia magna." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69519.

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The current work determined whether there is a constant tissue residue associated with narcotic compounds. In this investigation, the cladoceran, Daphnia magna was exposed to lethal levels (48h LC50) of ten, $ sp{14}$C-labelled, narcotic organic chemicals in a closed system. Exposure times, ambient concentrations, and body sizes were varied to evaluate their effects. The $ sp{14}$C-method developed in current work can detect chemicals in single D. magna in concentrations ranging from 0.02 to 6310 mmol/kg. Moreover, the technique detected phobic and lipophilic chemicals equally well. The techni

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14

Isnard, Hélène. "Application des traceurs isotopiques Pb-Pb, Sm-Nd et Lu-Hf à la compréhension de l'histoire archéenne du bouclier canadien et à la formation de la croûte continentale /." Thèse, Chicoutimi : Montréal : Université du Québec à Chicoutimi ;. Université du Québec à Montréal, 2003. http://theses.uqac.ca.

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Thèse (D.R.Min.) -- Université du Québec à Chicoutimi, programme extensionné à l'Université du Québec à Montréal, 2003.<br>Bibliogr.: f. 203-204. Document électronique également accessible en format PDF. CaQCU

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15

Yi, Peng. "Iodine Isotopes (129I and 127I) in the Baltic Sea : Tracer applications & environmental impact." Doctoral thesis, Uppsala universitet, Luft-, vatten och landskapslära, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182357.

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129I is a radioactive isotope (T1/2= 15.7 million years) produced through natural and anthropogenic pathways, but the anthropogenic production is presently dominating the Earth’s surface environments. Sparse data from previous investigations in the Baltic Sea clearly indicated the occurrence of 129I at levels 3-4 orders higher than natural pre-atomic era (before 1940) without comprehensive evaluation of distribution and inventory. In this thesis extensive data on the distribution and inventory of iodine isotopes, 129I and 127I, and their species in waters of the Baltic Sea, Kattegat and Skager

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16

Gramling, Carolyn M. "A radiocarbon method and multi-tracer approach to quantifying groundwater discharge to coastal waters." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/69769.

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Thesis (Ph. D.)--Joint Program in Marine Geology and Geophysics (Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), September 2003.<br>Includes bibliographical references.<br>Groundwater discharge into estuaries and the coastal ocean is an important mechanism for the transport of dissolved chemical species to coastal waters. Because many dissolved species are present in groundwater in concentrations that are orders of magnitude higher than typical river concentrations, groundwater-borne nutrients and pollut

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17

Stanley, Rachel H. R. "A determination of air-sea gas exchange and upper ocean biological production from five noble gasses and tritiugenic helium-3." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42282.

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Thesis (Ph. D.)--Joint Program in Chemical Oceanography (Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences; and the Woods Hole Oceanographic Institution), 2007.<br>Includes bibliographical references (p. 215-225).<br>The five noble gases (helium, neon, argon, krypton, and xenon) are biologically and chemically inert, making them ideal oceanographic tracers. Additionally, the noble gases have a wide range of solubilities and molecular diffusivities, and thus respond differently to physical forcing. Tritium, an isotope of hydrogen, is useful in tandem wit

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18

Eriksson, Jonas. "Synthesis of ¹¹C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbibliotekt [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7171.

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19

Casiraghi, Marina. "Functional modulation of a G protein-coupled receptor conformational landscape in a lipid bilayer." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC138/document.

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Les récepteurs couplés aux protéines G (GPCRs en anglais) représentent la famille de récepteurs intégrales de membrane plus vaste dans la majorité des cellules eucaryotes. Ils jouent un rôle clé dans la transduction de signal, ainsi que la compréhension de leur mécanisme de signalisation représente une des questions principales dans la biologie d'aujourd'hui. Dans la caractérisation du paysage énergétique de ces récepteurs à l'échelle atomique, les structures cristallographiques publiées pendant la décennie dernière par cristallographie aux rayons X représentent la percée scientifique majeure

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20

Bachaud, Pierre. "Stockage du CO₂ dans les aquifères profonds : Etude en conditions réelles des propriétés de confinement des roches de couverture et de leur altération." Thesis, Vandoeuvre-les-Nancy, INPL, 2010. http://www.theses.fr/2010INPL084N/document.

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Une solution prometteuse pour diminuer les émissions anthropogéniques de gaz à effet de serre consiste à injecter une partie des rejets industriels de CO2 dans des formations souterraines. Celles-ci comportent un réservoir entouré de roches de couverture, qui constituent la première barrière à la migration des fluides. La caractérisation de leurs propriétés de confinement et de leur évolution en présence de CO2 est donc un élément clé de la sécurité d’un site de stockage. Le travail présenté propose une méthodologie, appliquée ici à des roches carbonatées du bassin parisien, permettant de mesu

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21

Ogier, Lionel. "Synthèse de nouveaux analogues iodés du D-glucose." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10264.

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Chez l'homme, de nombreuses pathologies sont liees a des dysfonctionnements du transport cellulaire du d-glucose. Les techniques d'imagerie etant un outil precieux pour detecter ces anomalies de transport, la synthese d'analogues du d-glucose radiomarques a l'iode (emetteur gamma) et utilisables en imagerie spect, a ete entreprise selon deux approches : la premiere repose sur l'utilisation du motif beta-iodoethoxyle qui a ete introduit sur diverses positions (1, 4, 5 et 6) du glucose. La seconde consiste a conserver tous les hydroxyles du glucose en introduisant le motif iode a partir des carb

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22

Grimaldo, Morón José Teófilo. "Contribution à la synthèse de macrocycles tétraphosphorés : ligands polydentates présentant un intérêt biomédical." Grenoble 1, 1987. http://www.theses.fr/1987GRE10161.

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Synthese de ligands macrocycles tetraphores, complexants potentiels de cations paramagnetiques (gd**(3+), fe**(3+)) et de nucleide radioactifs. Etude de la reactivite de ces ligands et des essais de complexation

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23

Novel, Jean-Paul. "Contribution de la géochimie à l'étude d'un aquifère alluvial de montagne : cas de la vallée d'Aoste-Italie." Paris 6, 1995. http://www.theses.fr/1995PA066419.

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La gestion de la ressource en eau en milieu alluvionnaire de montagne, nécessite une définition à la fois de l'origine et de la dynamique des écoulements souterrains dans ce type d'aquifère. Cette définition implique par conséquent la prise en considération des autres compartiments du système hydrologique du domaine montagnard, c'est-à-dire les précipitations, le réseau de surface et les aquifères de versant. L'étude hydrogéologique de l'aquifère alluvial de la plaine d’Aoste (Italie), pris comme référence pour les alpes italo-franco-suisses, s'appuie en particulier sur l'utilisation de deux i

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24

Synhaeve, Nicholas. "Influence of a chronic 90Sr contamination by ingestion on the hematopoietic, immune and bone systems." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00656935.

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Strontium 90 (90Sr) is a radionuclide of anthropogenic origin released in large quantities in the environment as a result of nuclear atmospheric tests or accidents at nuclear facilities. 90Sr persists on a long-term basis in the environment, leading to chronic contamination by ingestion of populations living on contaminated territories. The induction of bone tumours associated with the fixation of 90Sr has been widely described. However, the occurrence of non-cancer effects is much less known. We used a mouse model with chronic contamination by ingestion of water containing 20 kBq/l of 90Sr. A

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25

Chiron, Rémi. "Ecarts à la loi d’Arrhenius dans l'autodiffusion du thallium cubique centre (Beta -TL) : appareillage et méthodes expérimentales originales pour des mesures de précision en diffusion." Paris 6, 1986. http://www.theses.fr/1986PA066232.

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Description de la méthode expérimentales de traceur radioactif et de sectionnement permettant la mesure précise des coefficients de diffusion de (204)TL dans TL-beta. Détermination de la précision atteinte sur la mesure du coefficient de diffusion. Détection d'une courbure positive dans le graphe d’Arrhenius. Explication des résultats.

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26

Moscatelli, Michel. "Role du molybdene dans la dissolution et la passivation d'alliages nickel-molybdene : influence du soufre." Paris 6, 1987. http://www.theses.fr/1987PA066542.

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Les effets d'amelioration des capacites de passivation apportees par le molybdene et les effets de depassivation induits par le soufre adsorbe et en solution solide ont ete etudies en milieu h::(2)so::(4) sur des alliages monocristallins a base de nickel contenant 2% et 6% de molybdene, a l'aide de techniques electrochimiques et radiochimiques (traceur s**(35))

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27

Montillet, Jean-Luc. "Dosage radioimmunologique du zinniol : application a l'etude de cette toxine dans l'alternariose de la carotte." Toulouse 3, 1986. http://www.theses.fr/1986TOU30208.

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Un dosage radioimmunologique specifique du zinniol a ete au point; les etapes de ce travail ont ete les suivantes: - synthese d'une molecule immunogene (conjugue zinniol-proteine porteuse). - obtention d'anticorps specifique (4 ci/mmole). - mise au point du dosage radioimmunologique valide du point de vue de sa specificite, de sa reproductibilite et de sa sensibilite (limite de detection 0,14 nn/essai). Cet outil a permis de realiser des dosages sur des plantes infectees. Ces resultats inedits montrent que la molecule est emise tres rapidement dans les tissus infectes (12 h apres inoculation).

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28

Duncan, Henry J. (Henry John). "An isotope washout technique to study skin perfusion pressure and vascular resistance in diabetes, hypertension and peripheral vascular disease." 1986. http://web4.library.adelaide.edu.au/theses/09MD/09mdd911.pdf.

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29

Duncan, Henry J. (Henry John). "An isotope washout technique to study skin perfusion pressure and vascular resistance in diabetes, hypertension and peripheral vascular disease / by Henry J. Duncan." Thesis, 1986. http://hdl.handle.net/2440/38294.

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30

Dulaiova, Henrieta Burnett William C. "Multiple isotopic tracers for study of coastal hydrological processes." Diss., 2005. http://etd.lib.fsu.edu/theses/available/etd-07052005-143117.

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Thesis (Ph. D.)--Florida State University, 2005.<br>Advisor: Dr. William C. Burnett, Florida State University, College of Arts and Sciences, Department of Oceanography. Title and description from dissertation home page (viewed Sept. 15, 2005). Document formatted into pages; contains xvi, 132 pages. Includes bibliographical references.

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31

Pritchard, Jodie Lee. "Dynamics of stream and groundwater exchange using environmental tracers." 2005. http://catalogue.flinders.edu.au/local/adt/public/adt-SFU20060407.122526/index.html.

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32

Worsnopp, Madeline Breeze. "Using radium and radon to evaluate ground water discharge and benthic exchange in upper Newport Bay, California." 2007. http://catalog.hathitrust.org/api/volumes/oclc/263028292.html.

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33

Fine, David Robert. "The use of anatomically based models for the analysis of imaged tracer experiments in humans." Thesis, 1994. https://hdl.handle.net/10539/23778.

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A thesis submitted to the faculty of Engineering, University of the Witwatersrand, Johannesburg , in fulfillment of the requirements for the degree of Doctor of Philosophy. Johannesburg, November 1994<br>Organ function is often characterised using imaging techniques. In particular a tracer is often used which does not react with tissue, is low in concentration, follows body fluid flows and is distinguishable from the observed system and thus measurable. These requirements ensure linear characteristics of the tracer. In this thesis, these linear characteristics are used to develop a genera

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34

Stanley, Rachel H. R. "A determination of air-sea gas exchange and upper ocean biological production from five noble gases and tritiugenic helium-3." 2007. http://hdl.handle.net/1912/2029.

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Thesis (Ph. D.)--Massachusetts Institute of Technology and Woods Hole Oceanographic Institution, 2007.<br>"September 2007". "Joint Program in Oceanography/Applied Ocean Science and Engineering"--Cover. Title from Web page (viewed on Mar. 24, 2008). Includes bibliographical references (p. 215-225).

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35

Mofokeng, Thelma. "Hydrochemical and environmental isotope based investigation of the Masama Ntane Sandstone Aquifer, Botswana." Thesis, 2017. http://hdl.handle.net/10539/23565.

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A research report submitted to the Faculty of Science school of Geosciences in partial fulfillment of the requirements for the degree of Masters of Science in Hydrogeology. Johannesburg, June 2017.<br>The Masama Sandstone Aquifer is located in a semi-arid region of south-eastern Botswana where there are no perennial rivers. Groundwater is the main source of water supply for the communities. Historically many water drilling programs have been carried out in this area and the hydrogeological system has been conceptualized. An integrated approach coupling environmental isotopes, radioisot

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36

Kiser, Matthew R. "Development of a System for Real-Time Measurements of Metabolite Transport in Plants Using Short-Lived Positron-Emitting Radiotracers." Diss., 2008. http://hdl.handle.net/10161/708.

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37

Furuichi, Takahisa. "Soil erosion and sedimentation in the Lake Inle catchment, Myanmar (Burma)." Phd thesis, 2007. http://hdl.handle.net/1885/149643.

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38

Everett, Sarah E. "Assessment of plutonium as a tracer of soil and sediment transport using accelerator mass spectrometry." Phd thesis, 2009. http://hdl.handle.net/1885/150859.

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39

Paproski, Robert Joseph. "Characterization of transport of positron emission tomography tracer 3'-deoxy-3'-fluorothymidine by nucleoside transporters." Phd thesis, 2010. http://hdl.handle.net/10048/909.

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Thesis (Ph.D.)--University of Alberta, 2009.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Oncology. Title from pdf file main screen (viewed on January 30, 2010). Includes bibliographical references.

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40

Andujar, Jacques-Étienne. "Rôle du cortex pariétal postérieur dans le processus d'intégration visuomotrice - connexions anatomiques avec le cortex moteur et activité cellulaire lors de la locomotion chez le chat." Thèse, 2011. http://hdl.handle.net/1866/6193.

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La progression d’un individu au travers d’un environnement diversifié dépend des informations visuelles qui lui permettent d’évaluer la taille, la forme ou même la distance et le temps de contact avec les obstacles dans son chemin. Il peut ainsi planifier en avance les modifications nécessaires de son patron locomoteur afin d’éviter ou enjamber ces entraves. Ce concept est aussi applicable lorsque le sujet doit atteindre une cible, comme un prédateur tentant d’attraper sa proie en pleine course. Les structures neurales impliquées dans la genèse des modifications volontaires de mouvements locom

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