Academic literature on the topic 'Radio frequency ablation; liver cancer; liver metastases'

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Journal articles on the topic "Radio frequency ablation; liver cancer; liver metastases"

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Hirata, Masaru. "Comparison Between Radio Frequency Ablation Therapy and Liver Resection for Liver Metastasis from Colorectal Cancer." Gastroenterology 152, no. 5 (April 2017): S295. http://dx.doi.org/10.1016/s0016-5085(17)31273-8.

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Livraghi, Tito, S. Nahum Goldberg, Luigi Solbiati, Franca Meloni, Tiziana Ierace, and G. Scott Gazelle. "Percutaneous Radio-frequency Ablation of Liver Metastases from Breast Cancer: Initial Experience in 24 Patients." Radiology 220, no. 1 (July 2001): 145–49. http://dx.doi.org/10.1148/radiology.220.1.r01jl01145.

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Gwak, Ji Hun, Bo-Young Oh, Ryung Ah Lee, Soon Sup Chung, and Kwang Ho Kim. "Clinical Applications of Radio-Frequency Ablation in Liver Metastasis of Colorectal Cancer." Journal of the Korean Society of Coloproctology 27, no. 4 (2011): 202. http://dx.doi.org/10.3393/jksc.2011.27.4.202.

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Hirata, Masaru. "Su1221 Comparison Between Radio Frequency Ablation Therapy and Liver Resection for Liver Metastasis From Colorectal Cancer." Gastroenterology 142, no. 5 (May 2012): S—453. http://dx.doi.org/10.1016/s0016-5085(12)61713-2.

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Hirata, Masaru. "S1283 Effect of Radio Frequency Ablation Therapy for Liver Metastasis From Colorectal Cancer." Gastroenterology 138, no. 5 (May 2010): S—220. http://dx.doi.org/10.1016/s0016-5085(10)60999-7.

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Hirata, Masaru. "Tu1534 - Comparable Effect of Radio Frequency Ablation Therapy to Liver Resection for Liver Metastasis from Colorectal Cancer." Gastroenterology 154, no. 6 (May 2018): S—954—S—955. http://dx.doi.org/10.1016/s0016-5085(18)33219-0.

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Pissas, Marie-Hélène, Sebastien Carrere, Lise Roca, Pierre-Emmanuel Colombo, Martin Bertrand, Olivia Sgarbura, Fabienne Portales, et al. "Prolonged survival after two-stage resection of advanced colorectal liver metastases: Impact of an intensified chemotherapy." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 748. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.748.

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748 Background: Patients with advanced colorectal liver metastases (CRLM) experience poor prognosis. The impact of two-stage resection (TSR) after downstaging by chemotherapy is still controversial. Methods: Data on 899 patients with CRLM in a single institution during a 9-year period (2004–2013) were prospectively collected. We used intent-to-treat analysis to evaluate the survival of patients who underwent TSR associated with intensified chemotherapy before and between the two surgical stages. Results: 73 patients were eligible for the first stage of TSR. In this population, 54 patients underwent an intensified chemotherapy based on FOLFIRINOX (26 patients) or a standard chemotherapy associated with cetuximab or bevacizumab (28 patients). The first surgical stage was a clearance of the left liver in 56% of cases. An average of two radio-frequency ablations and two wedge resections were necessary. The post-operative morbidity of the first stage was 18%. 78% of patients received chemotherapy between the two stages. The average interval between two stages was 228 days (36-1561). 68% of TSR patients completed the second stage. The second resection was mainly a standard right lobectomy (32%). Morbidity after the second resection was 12%. One patient died post-operatively because of post operative liver failure. Median overall survival of patients who completed TSR was 48 months. In contrast, there was no survival advantage for patients who underwent only the first stage because of progression (median overall survival: 19 months) (p = 0.0003). The median overall survival of the whole population was 43 months and the median recurrence-free survival was 15 months. Conclusions: Intensified chemotherapy in association with TSR allows excellent outcome in patients with advanced CRLM. Chemotherapy delivered between the two surgical stages is responsible for an important waiting time but could contribute to a better control of the evolution of the disease.
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MASUDA, TOSHIRO, GEORGIOS ANTONIOS MARGONIS, NIKOLAOS ANDREATOS, JAEYUN WANG, SAMUEL WARNER, MUHAMMAD BILAL MIRZA, ANASTASIOS ANGELOU, et al. "Combined Hepatic Resection and Radio-frequency Ablation for Patients with Colorectal Cancer Liver Metastasis: A Viable Option for Patients with a Large Number of Tumors." Anticancer Research 38, no. 11 (November 2018): 6353–60. http://dx.doi.org/10.21873/anticanres.12993.

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Zagoria, Ronald J., Y. M. Michael, Perry Shen, and Edward A. Levine. "Complications from Radio frequency Ablation of Liver Metastases." American Surgeon 68, no. 2 (February 2002): 204–9. http://dx.doi.org/10.1177/000313480206800221.

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The objective of this study is to evaluate complications from radiofrequency ablation of liver metastases. Eighty-one liver tumors in 38 consecutive patients were treated with radiofrequency ablation. All patients had one to six metastases treated in a single session. Eight patients underwent radiofrequency ablation intraoperatively after laparotomy and the remaining 30 patients were treated percutaneously with CT or ultrasound guidance. A total of 43 radiofrequency ablation procedures were studied. There was one (2%) mortality related to a hepatic abscess development 8 days after the procedure. One patient (3%) required a blood transfusion. Three patients (8%) developed severe upper abdominal or pleuritic chest pain that persisted several days after the procedure. We conclude that radiofrequency ablation of liver metastases is associated with a low rate of serious complications (two of 38; 5%). Complications requiring treatment usually develop several days after the procedure.
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Gillams, A. R., and W. R. Lees. "Radio-frequency ablation of colorectal liver metastases in 167 patients." European Radiology 14, no. 12 (July 27, 2004): 2261–67. http://dx.doi.org/10.1007/s00330-004-2416-z.

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Dissertations / Theses on the topic "Radio frequency ablation; liver cancer; liver metastases"

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Tiong, Leong Ung. "Improving the safety and efficacy of bimodal electric tissue ablation." Thesis, 2012. http://hdl.handle.net/2440/74060.

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Introduction: Bimodal electric tissue ablation (BETA) is a new method of ablation, which combines the process of electrolysis with radiofrequency ablation (RFA) to increase the size of tissue ablations. The cathode of the electrolytic circuit is connected to the radiofrequency (RF) electrode to increase the surrounding tissue hydration. This allows the RFA process to continue for a longer period of time and therefore produce larger ablations. Previous research has shown that BETA could produce larger ablations compared to standard RFA and that it did not produce any significant short or long-term complications. The studies described here aim to increase the knowledge on how BETA works to facilitate its translation into clinical practice to treat liver tumours. Materials & Methods The first study tested whether BETA really acts by increasing the hydration of tissues around the RF electrode. This was achieved by reversing the polarity of the electrolytic circuit, which theoretically would produce smaller ablations compared to standard RFA. The second study assessed where would be the best location (skin, parietal peritoneum or liver) for the anode of the electrolytic circuit during a BETA process. The third experiment determined whether the principle of BETA could be incorporated into the Cool-Tip RF system, which uses internally-cooled electrodes (ICEs). Results The duration of ablation when the polarity of the electrolytic circuit was reversed (called reversed polarity bimodal electric ablation, or RP-BEA) were significantly shorter compared to standard RFA and BETA (48s vs. 148s and 84s respectively, p=0.004). Consequently the size of ablations in RP-BEA was significantly smaller compared to RFA and BETA (9.1mm vs. 13.4mm and 11.6mm, p=0.001). The second experiment showed that the size of ablations were significantly larger when the anode of the electrolytic circuit was placed on the peritoneum or the liver, compared to when it was placed on the skin (19.7mm and 17.9mm vs. 12.4mm, p<0.001). Lastly, the third experiment showed that the principle of BETA could be incorporated into the Cool-Tip RF system to produce significantly larger ablations compared to standard RFA alone (23.1mm vs. 20.1mm, p<0.001). Discussion The results from this study confirmed the theory that BETA increases ablation size due to the effects of increased tissue hydration around the RF electrode. The increased hydration delays tissue desiccation during an ablation, thus allowing the process to continue for longer periods of time, therefore producing larger ablations. The efficacy of BETA depends on good electrical conductivity between the cathode and the anode of the DC circuit. Results from the second study showed that BETA works best when the anode of the electrolytic circuit was placed deep to the skin as the stratum corneum consisted of a layer of anucleated cells which have high electrical resistivity. Lastly, BETA could be incorporated into the Cool-Tip RF system (Covidien, ValleyLab), which is one of the popular RFA generators in the market. This means that BETA could be readily incorporated into existing RF generators, therefore facilitating its translation into the clinical settings.
Thesis (M.S.) -- University of Adelaide, School of Medicine, 2012
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Book chapters on the topic "Radio frequency ablation; liver cancer; liver metastases"

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Alexander, Graeme J. M., David J. Lomas, William J. H. Griffiths, Simon M. Rushbrook, and Michael E. D. Allison. "Primary and secondary liver tumours." In Oxford Textbook of Medicine, edited by Jack Satsangi, 3178–90. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0332.

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A number of benign and malignant tumours arise in the liver. Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. It is usually asymptomatic unless the cancer is advanced. Cross-sectional imaging with contrast with either CT or MRI is sufficient to make a firm diagnosis. Serum α‎-fetoprotein is elevated in most cases. Early diagnosis, perhaps through surveillance, increases the proportion of patients that can be considered for curative treatment, including surgical resection, radiofrequency ablation, or liver transplantation. The presence of symptoms denotes a poor prognosis, with less than 10% of patients surviving 3 years. Cholangiocarcinoma accounts for 7 to 10% of primary liver malignancies. The diagnosis of cholangiocarcinoma can be very difficult to make. Resection results in cure for only a few patients. Palliative approaches include photodynamic therapy, conventional radiotherapy, and high-dose local irradiation. Biliary stents relieve jaundice and may reduce the frequency of episodes of cholangitis. Haemangioma, usually an incidental finding, has a prevalence of 2 to 5% in the population. Focal nodular hyperplasia (prevalence 0.4–0.8%) is found predominantly in fertile women and is typically an incidental finding during abdominal imaging. Biopsy is required if there is diagnostic uncertainty and in particular to differentiate from hepatic adenomas. Interventions include surgery, radiofrequency ablation, transarterial embolization, or a combination of each according to location and patient fitness. Secondary tumours may be a presenting feature but more often are found during staging for primary malignancy or during follow-up. Symptoms include abdominal pain and hepatomegaly and later jaundice and ascites. For most patients with multiple metastases to the liver, the prognosis is poor and treatment palliative.
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Conference papers on the topic "Radio frequency ablation; liver cancer; liver metastases"

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Wang, Lulu, Mengke Ge, and Bensheng Qiu. "A Small Radio Frequency Sensor for Microwave Tumor Ablation." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-86766.

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This paper presents a small radio frequency sensor namely multi-slot antenna for liver tumor ablation at microwave spectrum. A computer simulation model was developed to validate the proposed antenna. The authors tested the proposed antenna on pig liver tissue samples. Both simulation and experimental results showed that the proposed multi-slot antenna has the potential for liver cancer treatment in the future.
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Den Adel, Colleen, Zena-Maria Husler, and Yen-Lin Han. "Design of a Novel Radio Frequency Ablation Probe for Tumor Ablation Treatment." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3508.

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Hepatocellular carcinoma (HCC), commonly known as the liver cancer, is a severe health concern worldwide. For patients with liver tumors that are difficult to remove through traditional treatments such as radiation, chemotherapy and partial hepatectomy, there is the option of radiofrequency ablation (RFA) treatment. RFA is a minimally invasive procedure that is currently treating liver tumors that are relatively small in size. Radiofrequency ablation uses currents to heat up the tissue of the tumor. Once the temperature of the tissue reaches approximately 60° C tissue necrosis begins to occur [1]. With current RFA probes, ablation lesions are typically 3–5.5 cm in diameter [2]. It is important that all of the tumor tissue is ablated, so it is necessary to also kill a small amount of the surrounding healthy tissue. At least 1 cm of healthy tissue should be ablated to ensure the tumor will not recur [2]. Hence, many studies [3, 4] have attempted to increase the RFA ablation zone through various methods including adding saline to the tissue, predicting the optimal power level, etc. To focus on safely increasing the size of the ablation zone and to improve upon the spherical geometry of the tumors, the “Christmas tree” and “umbrella” style probes [5], which utilize multi-pronged electrodes (tines), are currently available in the market. The electrodes, or wires of the probe, are responsible for producing heat and making contact with the liver tissue at all time in order to execute the tissue ablation. For the umbrella and Christmas tree style probes, the drawbacks include: 1. the gauge of the tines limit the ablation scope of the probes; 2. their ability to achieve higher volumes of cell death are limited due to their static geometry, which has fixed diameters; 3. towards the outer edge of the tumor, due to their static geometry and the loss of contact with live tissues, the rate of killing cancerous cells decreases drastically due to the decrease in heat transfer rate, which is a result of the lack of heat sink from perfusion in the live tissues [6]. It was noticed that an improvement could be made to the efficiency of these multi-pronged electrodes if they were free to expand as the area of tissue was ablated. Therefore, a novel dynamic RFA probe was proposed by Lau and Han and numerical simulations using COMSOL Multiphysics Joule heating module have concluded that this dynamic RFA probe can achieve a higher ablation volume with a shorter procedure time [7]. The main goal of this study is to realize the design of this dynamic RFA probe with expandable electrodes to create the largest and most replicable ablation zone. In this study, the deployment mechanism and the proposed design of the dynamic probe are discussed and the analytical solutions of the electrode expansion profiles are presented. The ablation zones are estimated analytically based on the dynamic expansion of the electrodes.
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Pandey, Ajit K., Isaac Chang, Matthew R. Myers, and Rupak K. Banerjee. "Finite Element Analysis of Radio-Frequency Ablation in a Reconstructed Realistic Hepatic Geometry." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32046.

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Radio-frequency (RF) ablation is a minimally invasive procedure that has the potential for widespread use in hepatic cancer therapy. In the procedure, RF current is applied to the tissue, resulting in the conversion of electrical to heat energy and thus, a rise in temperature, with the goal of eventual tumor necrosis. Potential complications from the procedure include insufficient heating of large tumors, resulting in tumor recursion, as well as excessive thermal damage to healthy tissue. Mathematical models are valuable in predicting the temperature rise within the organ during RF ablation, thereby enhancing the success rate of the procedure. Eventually, models can be used to guide ablation procedures, by predicting the optimal set of operational parameters e.g., catheter probe geometry and placement, given patient-specific information. The present study focuses on the analysis of temperature rise within a reconstructed model of a realistic three-dimensional (3D) section of a porcine liver during RF ablation. This study calculates the effect of blood flow through arteries as well as perfusion through the liver on the time-dependent temperature distribution near the RF ablation probe (Figure 1). For a time duration of 30 min of an ablation procedure, a temperature of about 80°C could be achieved over a diameter of about 4 cm with the present RF probe. As an initial step, the present study includes isotropic hepatic tissue and blood properties.
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