Academic literature on the topic 'Radiation-induced fibrosi'
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Journal articles on the topic "Radiation-induced fibrosi"
Borrelli, Mimi R., Abra H. Shen, Gordon K. Lee, Arash Momeni, Michael T. Longaker, and Derrick C. Wan. "Radiation-Induced Skin Fibrosis." Annals of Plastic Surgery 83 (October 2019): S59—S64. http://dx.doi.org/10.1097/sap.0000000000002098.
Full textKim, Jin-Mo, Hyun Yoo, Jee-Youn Kim, Sang Ho Oh, Jeong Wook Kang, Byung Rok Yoo, Song Yee Han, et al. "Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3." Cellular Physiology and Biochemistry 48, no. 3 (2018): 959–70. http://dx.doi.org/10.1159/000491964.
Full textTopuzov, E. E., T. T. Agishev, K. A. Fedorov, D. A. Krasnozhon, A. B. Vats, D. V. Romanovsky, G. A. Dashyan, et al. "Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer." HERALD of North-Western State Medical University named after I.I. Mechnikov 10, no. 2 (December 15, 2018): 58–63. http://dx.doi.org/10.17816/mechnikov201810258-63.
Full textWeigel, C., P. Schmezer, C. Plass, and O. Popanda. "Epigenetics in radiation-induced fibrosis." Oncogene 34, no. 17 (June 9, 2014): 2145–55. http://dx.doi.org/10.1038/onc.2014.145.
Full textXavier, Sandhya, Ester Piek, Makiko Fujii, Delphine Javelaud, Alain Mauviel, Kathy C. Flanders, Ayelet M. Samuni, et al. "Amelioration of Radiation-induced Fibrosis." Journal of Biological Chemistry 279, no. 15 (January 19, 2004): 15167–76. http://dx.doi.org/10.1074/jbc.m309798200.
Full textHoeller, Ulrike, Michael Bonacker, Amira Bajrovic, Winfried Alberti, and Gustav Adam. "Radiation-Induced Plexopathy and Fibrosis." Strahlentherapie und Onkologie 180, no. 10 (October 2004): 650–54. http://dx.doi.org/10.1007/s00066-004-1240-3.
Full textBlakaj, A., X. Chi, W. F. Mourad, E. Herzog, L. Leng, and R. Bucala. "Metallothioneins in Fibrosis: Implications for Radiation-Induced Fibrosis." International Journal of Radiation Oncology*Biology*Physics 90, no. 1 (September 2014): S684—S685. http://dx.doi.org/10.1016/j.ijrobp.2014.05.2011.
Full textLiu, Chun-Shan, Reka Toth, Ali Bakr, Ashish Goyal, Md Saiful Islam, Kersten Breuer, Anand Mayakonda, et al. "Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response." Cancers 13, no. 10 (May 18, 2021): 2455. http://dx.doi.org/10.3390/cancers13102455.
Full textHorton, Jason A., Fei Li, Eun Joo Chung, Kathryn Hudak, Ayla White, Kristopher Krausz, Frank Gonzalez, and Deborah Citrin. "Quercetin Inhibits Radiation-Induced Skin Fibrosis." Radiation Research 180, no. 2 (July 2, 2013): 205. http://dx.doi.org/10.1667/rr3237.1.
Full textRosenbloom, Joel. "Therapeutic Approaches to Radiation-Induced Fibrosis." Journal of Cancer Treatment and Diagnosis 2, no. 4 (August 1, 2018): 7–9. http://dx.doi.org/10.29245/2578-2967/2018/4.1144.
Full textDissertations / Theses on the topic "Radiation-induced fibrosi"
Meziani, Lydia. "Study of Interaction Between the Inflammatory Response and Radiation-Induced Fibrosis." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA11T041.
Full textRadiation-induced fibrosis (RIF) is a delayed complication of radiotherapy often associated with chronic inflammatory process and macrophage infiltration. Nowadays, macrophages are suggested to be important cellular contributors to fibrogenic process, but their implication in the context of RIF has never been investigated. In a previous study we have shown that irradiation (IR) induced the polarization of cardiac macrophages into M1 in ApoE-/- mice and was associated with a high fibrosis score in ApoE-/- mice, suggesting that macrophage polarization could drive tissue sensitivity to ionizing radiation. This observation prompted us to investigate the role of macrophages in RIF using a classical experimental model of lung fibrosis developed in C57Bl/6 mice after 16Gy thorax-IR. We profiled both alveolar macrophages (AM) and interstitial macrophages (IM). During the acute phase we found AM depletion associated with CXCL1, MCP-1 and M-CSF secretion, followed by a repopulation phase mediated by recruitment and proliferation of monocytes/macrophages from the bone marrow. Interestingly, the newly recruited AM exhibited a yet never described hybrid polarization (M1/M2), associated with the up-regulation of both Th1 and Th2 cytokines. At delayed times points, IM were M2-polarized and associated with downregulation of Th1 cytokines and upregulation of Th2 cytokines in tissue lysates. These results suggest a differential contribution of hybrid AM vs M2 IM to fibrogenesis. Interestingly, in contrast to activated hybrid AM, activated M2 IM were able to induce fibroblast activation in vitro mediated by an enhanced TGF-β1 expression. Therefore, specific depletion of hybrid AM using intranasal administration of clodrosome increased RIF score and enhanced M2 IM infiltration. We next evaluated if the fibrogenic process can in turn affect macrophage polarization. Interestingly, after coculture of irradiated fibroblast with non-irradiated pulmonary macrophages, secretion of cytokines such as M-CSF and TIMP-1, which can stimulate macrophage activation, was observed. Furthermore, RIF inhibition using pravastatin treatment showed that fibrosis inhibition was associated with a decrease in M2 IM accompanied by an increase in M1 IM, but had no effect on polarization of AM. These present study shows a dual and opposite contribution of alevolar versus intertitial macrophages in RIF and the contribution of the fibrogenic process to IM polarization, resulting thereby in a chronical fibrogenic loop
Hamama, Saad. "Radiation-induced fibrosis : Characterization of the anti-fibrotic mechanisms displayed by pentoxifylline/vitamin E." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T071.
Full textRadiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials as treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored. We showed efficacy of Pentoxifylline-vitamin E combination in radiation-induced enteropathy in a small clinical study. In parallel, using a unique in vitro model of primary smooth muscle cells isolated from intestinal samples isolated from humans with radiation enteropathy we showed that pentoxifylline and the hydrophilic analogous of vitamin E (trolox) synergize to inhibit TGF-β1 protein and mRNA expression. This inhibitory action is mediated at the transcriptional level and leads to subsequent inhibition of TGF-β1/Smad targets (Col Iα1, FN1, PAI-1, CTGF), while it has no effect on the Rho/Rock pathway. We have also demonstrated, for the first time, an overexpression of the hypoxia-induced microRNA miR-210 in the fibrotic cells. Pentoxifylline-trolox combination could reverse this miR-210 overexpression in normoxic and hypoxic conditions. While miR-210 has not been previously shown to be involved in radiation-induced enteropathy, we showed that miR-210 inhibitor could reduce mRNA expression of Col Iα1. The anti-fibrotic effect of combined pentoxifylline-vitamin E is at least in part mediated by inhibition of the TGF-β1 cascade. MiR-210 inhibition is another mechanism which needs further investigations. This study strengthens previous clinical data showing pentoxifylline-vitamin E synergy and supports its use as a first-line treatment of radiation-induced fibrosis. Also, it suggests miR-210 as a new potential therapeutic target for the treatment of this complication
Kadokawa, Yoshio. "All-trans retinoic acid prevents radiation-or bleomycin-induced pulmonary fibrosis." Kyoto University, 2009. http://hdl.handle.net/2433/124297.
Full textOkoshi, Kae. "All-trans-retinoic acid attenuates radiation-induced intestinal fibrosis in mice." Kyoto University, 2008. http://hdl.handle.net/2433/135833.
Full textLemay, Anne-Marie. "Identification of bleomycin and radiation-induced pulmonary fibrosis susceptibility genes in mice." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92173.
Full textLavigne, Jérémy. "Changements phénotypiques des cellules endothéliales irradiées au cours du développement des lésions radiques pulmonaires." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066308/document.
Full textRadiation-induced endothelial dysfunction is known to participate to the development of normal tissue damage. PAI- is implicated in the phenotypic changes of irradiated endothelial cells and KOendo mice are protected from radiation damage to the gut. Whole thorax of PAI-1 KOendo and floxed mice were exposed to 17 Gy. Histological analyzes showed that PAI-1 KOendo induces a worsening of injuries at 2 and 13 weeks. Consequently, contrary to the gut no protection from radiation-induced lung damage is observed in PAI-1 KOendo mice. Our second aim was to study the effects of a single high dose stereotactic irradiation on pulmonary tissues. Histological analyzes and scanner imaging show important injuries on the targeted volume. An ipsilateral edema can also be observed 2 weeks after irradiation. Ipsilateral lung is moreover importantly damaged. A thickening of alveolar septa is notably observable. A transcriptomic analysis show important similarities between tissues from the ipsilateral lung and the focal lesion. As really highly damages have been observed in both scanner and histological analyzes, we decided to perform forced physical activity test on treadmill. A drastic decrease of maximal distance traveled has been observed from two weeks. These experiments highlighted a deficiency in respiratory function and all of these results show the importance of non-targeted irradiated pulmonary volume in the development of radiation-induced fibrosis. Effect of an endothelium-specific deletion of HIF-1α has been investigated in this model of stereotactic irradiation. Only few differences have been observed between KOendo and control mice. Experiments are still ongoing
Cappuccini, Federica [Verfasser], and Verena [Akademischer Betreuer] Jendrossek. "Radiation-induced pneumonitis and fibrosis - Defining the role of immune cells and regulatory molecules / Federica Cappuccini ; Betreuer: Verena Jendrossek." Duisburg, 2017. http://d-nb.info/1141053586/34.
Full textDardaillon, Rémi. "Fibres optiques passives et actives sous irradiation : application à l'amplification et à la dosimétrie en environnement spatial." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTS052/document.
Full textErbium-doped optical fibers open up many applications, especially in the field of terrestrial and underwater telecommunications, with optical amplifiers. Nowadays, there is a real interest for the space industry to use these fibers in satellites. However, in order to use their full potential, qualification in radiative environments is to be carried out, this is the main focus of this PhD work. Thanks to the partnership with Draka-Prysmian group, we have a full access to a large diversity of specialty fibers, in terms of chemical compositions : this allows us to study their sensitivity to radiations, and to determine the important role of dopants and co-dopants in this sensitivity. A real-time study of it, associated with a qualification of pristine and irradiated optical samples, enables the detection of radiation-induced defects, and the understanding of their creation process, as a function of the fiber structure. This study provides a physical model describing the degradation and the recovery of these fibers, enhanced with an amplifier modeling. It allows the prediction of the quantitative behavior of specialty fiber-based amplifiers, in terms of gain and bandwidth, versus the chemical composition of the fibers used, for a typical space mission dose ; thus this modeling meets the needs of the spatial market key actors. Furthermore, the benefit of this work opens up another avenues for some larger opportunities, in various radiative environments, such as the medical field or the areas of nuclear facilities
Di, Francesca Diego. "Roles of dopants, interstitial O2 and temperature in the effects of irradiation on silica-based optical fibers." Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET4002/document.
Full textIn this Thesis work we have investigated the effect of ionizing irradiation (X and γ rays) up to 1 Grad on different types of multimode optical fibers (P-doped, P-Ce-doped , Ge-doped, Ge-F-doped, Ge-Ce-doped, and N-doped). The experiments were carried out by three main experimental techniques: online Radiation Induced Attenuation (RIA), Electron Paramagnetic Resonance (EPR) and Confocal Micro-Luminescence (CML). In the first part of the Thesis work we report on the radiation response of several types of optical fibers. The absorption due to radiation induced P-related defects was studied by RIA in the UV-Visible domain. Moreover, by EPR measurements we were able to detect POHC, P1 and P2 defects. In particular, for the detection of P1 and P2 defects we have validated the use of EPR second-harmonic detection mode which allowed us to obtain the growth kinetics of P1 and P2 with the dose. The effects due to the variation of the drawing conditions of the fibers were investigated as well as the ones due to the change of the temperature of irradiation (from 25 to 280 °C). Finally, concerning the P-doped OFs, we report on the effects due to the Cerium codoping of the core of the optical fiber. We observed a reduced generation of POHC and P2 centers under irradiation. However, EPR investigation has shown that the generation of P1 defects is essentially unaffected by the Ce-codoping. Regarding Ge-doped optical fibers we report on three basic typologies: Ge-doped, Ge-F-doped and Ge-Ce-doped. For each fiber typology we investigated three drawing conditions. The radiation responses of these fibers were characterized by RIA and EPR measurements. Furthermore, performing CML measurements we were able to obtain further insight on the role of the co-dopants and of the defect precursors in determining the radiation induced defects. We have also investigated the radiation response of N-doped OFs (three drawing conditions). The radiation responses in the UV-Visible domains were obtained by RIA, and by EPR measurements we were able to detect the signals of two N-related defects at high radiation doses. Finally, CML measurements on irradiated samples have shown three emission bands in the visible domain which are tentatively assigned to N-related centers. In the second part of the Thesis we report on the effects of an O2 loading treatment produces on some of the investigated samples. By micro-Raman measurements we demonstrate that a high pressure high temperature treatment can incorporate high quantity of O2 into Pure-Silica-Core (PSC), F, Ge and P doped optical fibers. The radiation responses of some of the O2-loaded optical fibers were investigated with particular regard to the fluorine doped and pure-silica-core optical fibers. On the basis of literature data we performed band decompositions of the RIA spectra as a function of the dose. Moreover, the EPR study of the O2 loaded P-doped optical fiber have shown a strong reduction of the signals associated to the P1 and P2 defects as compared to the untreated fibers. In this part of the thesis we also report on the characterization of the near infrared radioluminescence (1272 nm) of O2 molecules embedded in the optical fiber matrix and the feasibility of a radiation sensor based on this phenomenon for environments characterized by high radiation doses and high dose-rates
Lecomte, Pierre. "Mesure haute température en environnement irradié par fibre optique utilisant l’effet Raman." Thesis, Perpignan, 2017. http://www.theses.fr/2017PERP0067/document.
Full textEDF is working on Raman distributed temperature sensing using optical fiber sensors in order to map temperature of nuclear power plants big components. The sensor has to sustain harsh environmental conditions (temperatures up to 350 °C and gamma ionizing radiations). Ionizing radiations can create structural defects inside the fiber’s core, which attenuate the light transmission. This phenomenon can lead to temperature measurements errors until no measurement is possible. As for high temperature, it can affect the fiber coating, which mitigate the fiber mechanical resistance.Gamma rays in situ irradiations have been carried out over commercial off-the-shelf multimode gold coated fibers protected with a stainless steel metal tubing, with two different radiation sources, in order to observe radiation-induced attenuation over dose rate or cumulated dose. Effects of gamma rays over gold coated optical fiber sensors have been observed at both room anhigh temperature.This experimental work enlightens that high temperature can be controlled with gold coated fibers, and that the radiation-induced attenuation downsides can efficiently be balanced with high temperature. Implementation of a Raman distributed temperature optical fiber sensor in such harsh environments becomes possible, as well as the associated estimation of measurement uncertainty
Book chapters on the topic "Radiation-induced fibrosi"
Rodemann, H. Peter, Anke Binder, and Michael Bamberg. "Radiation-Induced Fibrosis: Experimental Studies." In Late Sequelae in Oncology, 93–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-46794-3_13.
Full textJacobson, Geraldine. "Pentoxifylline, Vitamin E, and Modification of Radiation-Induced Fibrosis." In Oxidative Stress in Cancer Biology and Therapy, 357–72. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-397-4_17.
Full textSime, Patricia J., R. Matthew Kottmann, Heather F. Lakatos, and Thomas H. Thatcher. "The Role of TGF-β in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-β as a Novel Therapeutic Strategy." In Transforming Growth Factor-β in Cancer Therapy, Volume I, 629–47. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-292-2_40.
Full textWard, William F., and Yoon T. Kim. "Radiation-Induced Pulmonary Fibrosis." In CRC Handbook of Animal Models of Pulmonary Disease, 165–82. CRC Press, 2018. http://dx.doi.org/10.1201/9781351070966-10.
Full textRosenow, Edward C. "Pulmonary Disease in the Immunocompromised Host (ICH)." In Mayo Clinic Challenging Images for Pulmonary Board Review, 893–98. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199756926.003.0116.
Full textPerez, Jessica Rika. "Radiation-Induced Lung Injury Imaging." In Emerging Developments and Practices in Oncology, 218–38. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3085-5.ch008.
Full textJIRTLE, R. L., and M. S. ANSCHER. "THE ROLE OF TGF-β1 IN THE PATHOGENESIS OF RADIATION INDUCED HEPATIC FIBROSIS." In Radiation Research: A Twentieth-century Perspective, 27. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-12-168561-4.50043-3.
Full textJirtle, Randy L., and Mitchell S. Anscher. "THE ROLE OF TGF-β1 IN THE PATHOGENESIS OF RADIATION-INDUCED HEPATIC FIBROSIS." In Congress Proceedings, 819–23. Elsevier, 1992. http://dx.doi.org/10.1016/b978-0-12-168562-1.50146-4.
Full textDe Broe, Marc E., Channa Jayasumana, Patrick C. D’Haese, Monique M. Elseviers, and Benjamin Vervaet. "Chronic tubulointerstitial nephritis." In Oxford Textbook of Medicine, edited by John D. Firth, 4956–74. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0490.
Full textHarada, Aki, Wei Li, Chao Li, Michael Idowu, Mitchell S. Anscher, and Youngman Oh. "Statin Inhibits Radiation-Induced Fibrosis through Regulation of CTGF/IGFBP-rP2 Action in Lung Fibroblasts." In BASIC/TRANSLATIONAL - IGF & IGF Binding Proteins, P1–151—P1–151. The Endocrine Society, 2011. http://dx.doi.org/10.1210/endo-meetings.2011.part1.p6.p1-151.
Full textConference papers on the topic "Radiation-induced fibrosi"
Henschel, H., O. Kohn, and H. U. Schidt. "Radiation Damage And Radiation Induced Loss In Optical Fibres." In OE/FIBERS '89, edited by Roger A. Greenwell and Dilip K. Paul. SPIE, 1990. http://dx.doi.org/10.1117/12.963227.
Full textAsha, S., N. Parushuram, K. S. Harish, S. Ganesh, and Y. Sangappa. "Radiation induced effects on silk fibroin films." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122576.
Full textYang, Xiaofeng, Peter Rossi, Joseph Shelton, Debrorah Bruner, Srini Tridandapani, and Tian Liu. "3D ultrasound Nakagami imaging for radiation-induced vaginal fibrosis." In SPIE Medical Imaging, edited by Johan G. Bosch and Marvin M. Doyley. SPIE, 2014. http://dx.doi.org/10.1117/12.2043862.
Full textTheodosiou, Antreas, Arnaldo Leal, Carlos Marques, Anselmo Frizera, Antonio Fernandes, Andrei Stancalie, Andreas Ioannou, Daniel Negut, and Kyriacos Kalli. "Radiation induced effects on FBGs using different femtosecond laser inscription methods." In Micro-structured and Specialty Optical Fibres VII, edited by Pavel Peterka, Kyriacos Kalli, and Alexis Mendez. SPIE, 2021. http://dx.doi.org/10.1117/12.2592376.
Full textWest, R. H. "Radiation Induced Losses In Pure Silica Core Fibres." In Cambridge Symposium-Fiber/LASE '86, edited by Roger A. Greenwell. SPIE, 1987. http://dx.doi.org/10.1117/12.937628.
Full textCaussanel, M., G. Beauvois, H. Duval, S. Grieu, G. Montay, and O. Gilard. "Radiation-Induced Attenuation Data of Polarization-Maintaining Fibres." In 2017 17th European Conference on Radiation and Its Effects on Components and Systems (RADECS). IEEE, 2017. http://dx.doi.org/10.1109/radecs.2017.8696161.
Full textKashaykin, Pavel F., Alexander L. Tomashuk, Irina S. Azanova, Olga L. Vokhmyanina, Tatiana V. Dimakova, Igor A. Maltsev, Yulia O. Sharonova, Elena A. Pospelova, and Evgueni M. Dianov. "Gamma-radiation-induced attenuation of light in polarization-maintaining pure-silica-core PANDA fibers." In Micro-structured and Specialty Optical Fibres, edited by Pavel Peterka, Kyriacos Kalli, and Alexis Mendez. SPIE, 2019. http://dx.doi.org/10.1117/12.2520430.
Full textPalmer, M. "Monocarboxylate Transporter (MCT) Proteins as Targets for Radiation-Induced Pulmonary Fibrosis." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5338.
Full textDegan, Simone. "Gastrin-Releasing Peptide (GRP) Promotes Radiation-Induced Pulmonary Inflammation And Fibrosis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1998.
Full textWu, Szu-yuan. "Abstract 4151: Fucoidan reduced radiation-induced fibrosis and secondary primary cancers." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4151.
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