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1
Sopandi, Wahyu. "Sosialisasi dan Workshop Implementasi Model Pembelajaran RADEC Bagi Guru-Guru Pendidikan Dasar dan Menengah [Dissemination and Implementation Workshop of RADEC Learning Models for Primary and Secondary Education Teachers]." PEDAGOGIA: Jurnal Pendidikan 8, no. 1 (April 16, 2019): 19. http://dx.doi.org/10.21070/pedagogia.v8i1.1853.
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This study investigated the impact of socialization and workshops about the Read- Answer-Discuss-Explain-and Create (RADEC) learning model on teacher readiness to implement it. The investigation involved 92 teachers (elementary school, middle school, and high school teachers). The research instrument was a questionnaire consisting of two parts. The first part questionnaire was given before the activity and was intended to reveal the experience of the teachers to implement currently familiar innovative learning models. The second part questionnaire was given after the activity and was intended to reveal the teachers' readiness to implement the RADEC learning model. Data were processed quantitatively and qualitatively. The research results of the first questionnaire show that teachers had not been able to implement currently familiar innovative learning models for various reasons. The research results of the second indicate that the social- ization and workshop can prepare teachers to implement the RADEC learning model. This can be seen from the majority of those who argue that (1) the syntax of the RADEC learning model is easy to remember and understand; (2) the RADEC learning model can practice 21st century skills; and (3) they are interested in researching the implementation of the RADEC learning model.
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Pharande, Shilpa Venkatesh. "Assessment of Immediate Skeletal Changes after Alternate Rapid Maxillary Expansion and Constriction – A Case Report." Journal of Evolution of Medical and Dental Sciences 10, no. 34 (August 23, 2021): 2954–59. http://dx.doi.org/10.14260/jemds/2021/604.
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The Alt-RAMEC protocol was introduced by Liou in the year 2005. It allows for sutural mobilisation by opening and closing the RME screw for 7-9 weeks. Maxillary protraction after the use of Alt-Ramec (alternate rapid maxillary expansion and contraction) protocol is an efficient method for early treatment of skeletal Class III malocclusion. This case report shows the results of using a hyrax bonded maxillary expander with the Alt-RAMEC protocol to treat a maxillary hypoplasia Class III malocclusion. A 12-year-old patient with skeletal class III malocclusion with anterior as well as the unilateral posterior crossbite was treated using this protocol. CBCT scans were taken before and after expansion. These CBCT scans were used for assessing and analysing the skeletal changes that have occurred after using the AltRamec protocol. The objective of this case report is to assess skeletal changes after using the Alt-RAMEC protocol.
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Chen, Zhi-Yong, Guo-Gang Feng, Kimitoshi Nishiwaki, Yasuhiro Shimada, Yoshihiro Fujiwara, Toru Komatsu, and Naohisa Ishikawa. "Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 2 (August 2007): H959—H967. http://dx.doi.org/10.1152/ajpheart.00886.2006.
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The present study was undertaken to determine whether neuropeptide Y (NPY) induces proliferation of rat aortic endothelial cells (RAECs). Since NPY increased the permeability of RAEC monolayers to large molecules via the NPY Y3 receptor, RAEC proliferation has been evaluated in terms of NPY-receptor subtypes and also intracellular mechanisms. RAECs were incubated with gases containing 20, 15, or 10% O2 and a certain amount of N2, depending on the O2 content in 5% CO2 incubators. NPY (10−9–10−6 M) increased the RAEC numbers under hypoxic conditions, such as 15 or 10% O2. Peptide YY elicited no proliferative effect on RAEC, and NPY-(18-36) inhibited the NPY-induced increase in cell number, suggesting that NPY increases the RAEC count through the NPY Y3 receptor. Pertussis toxin, U-73122, GF-109203X, myristorylated autocamtide-2-related inhibitory peptide, and wortmannin inhibited the NPY-induced proliferation of RAEC concentration dependently. DY9760e little affected the proliferation caused by NPY. ML-9 and imatinib actually enhanced the NPY-induced proliferation of cells. These results indicated that the NPY Y3 receptor is coupled with Gi protein, and that NPY-induced increases in RAEC proliferation are mediated by phospholipase C-protein kinase C and/or phosphatidylinositol 3-kinase pathways. In intracellular Ca2+-calmodulin-dependent pathways, calmodulin-dependent protein kinase II partly participates in the NPY-induced cell proliferation. Regarding the previously reported effect of NPY on the permeability of RAEC monolayers to large molecules, it is probable that protein kinase C and phosphatidylinositol 3-kinase pathways are activated for both permeability and cell proliferation induced by NPY under hypoxia, relevant to new insights into the roles of NPY in ischemia-hypoxia.
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Therrien, William J., James F. Kirk, and Suzanne Woods-Groves. "Comparison of a Reading Fluency Intervention With and Without Passage Repetition on Reading Achievement." Remedial and Special Education 33, no. 5 (June 23, 2011): 309–19. http://dx.doi.org/10.1177/0741932511410360.
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The purpose of this study was to compare the effect of a repeated reading and question generation intervention entitled Re-read-Adapt and Answer-Comprehend (RAAC) with a modified RAAC intervention without the repeated reading component. The sample included 30 students in Grades 3 through 5. The students received services in reading within a three-tiered response to intervention framework or in special education. Students were randomly assigned to the nonrepetitive condition or the control repeated reading condition and participated in 50 intervention sessions over a 4-month period. Regardless of condition, all students made gains in oral reading fluency on independent passages. The modified RAAC program without passage repetition appeared to be as effective if not more so at increasing reading fluency when compared to the RAAC program with passage repetition.
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Wang, Yu-Chi, Peter M. S. Chang, and Eric Jein-Wein Liou. "Opening of Circumaxillary Sutures by Alternate Rapid Maxillary Expansions and Constrictions." Angle Orthodontist 79, no. 2 (March 1, 2009): 230–34. http://dx.doi.org/10.2319/031208-141.1.
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Abstract Objective: To analyze quantitatively the circumaxillary suture opening after alternate rapid maxillary expansions and constrictions (Alt-RAMEC). Materials and Methods: Twelve inbred cats were randomly grouped into two equal groups for 1 week of rapid maxillary expansion (RME) (1 mm/day) or 5 weeks of Alt-RAMEC (1 mm/day). At the end of the experiment, the craniofacial skeleton of each cat was harvested. Each circumaxillary suture was then probed at three sites with a 0.5-mm pointed periodontal probe. A smooth probing without penetration was an ineffective suture opening (<0.5 mm), while a probing with penetration was an effective suture opening (>0.5 mm). For each suture, the quantity of suture opening (%) was the effective suture opening/(effective + ineffective suture opening). The intergroup differences were analyzed by chi-square test (P < .05). Results: Five weeks of Alt-RAMEC opened the circumaxillary sutures significantly more than 1 week of RME. This affected the circumaxillary sutures running coronally and articulating directly to the maxilla (56.9% vs 36.1%, P < .001), the sutures running sagittally, but articulating indirectly to the maxilla (94.4% vs 64.8%, P < .001), and the sutures running coronally, but articulating indirectly to the maxilla (58.3% vs 33.3%, P < .01). The sutures running sagittally were opened significantly more (94.4%–100.0%) than those running coronally (56.9%–58.3%), no matter if they articulated directly or indirectly with the maxilla. Conclusions: Alt-RAMEC opens both the sagittally and coronally running circumaxillary sutures quantitatively more than conventional RME. However, more than 5 weeks of Alt-RAMEC would be needed to increase the opening of the coronally running circumaxillary sutures. (Angle Orthod. 2009:79; )
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Wyenandt, C. Andrew, and Wesley L. Kline. "EVALUATION OF SKIN SEPARATION (SILVERING) IN FRUIT OF BELL PEPPER CULTIVARS." HortScience 41, no. 3 (June 2006): 494D—494. http://dx.doi.org/10.21273/hortsci.41.3.494d.
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Twenty-eight bell pepper cultivars and breeding lines were evaluated for resistance to the crown and stem rot phase of Phytophthora blight (Phytophthora capsici) and for silvering of fruit at two sites in southern New Jersey in 2005. A randomized complete block design with four replications was setup at Rutgers Agricultural Research and Extension Center (RAREC), Bridgeton, New Jersey and at an on-farm site in Vineland, NJ. Number and weight of fruit with silvering varied significantly depending on pepper line, harvest date, and location. Percentage of phytophthora-infected plants ranged from 0% to 26% at RAREC and 0% to 78% at the on-farm site depending on pepper line. In some cases, new breeding lines exhibited levels of Phytophthora-resistance comparable to the resistant cultivar Paladin. Depending on pepper line, percentage of harvested fruit with silvering decreased with later harvest dates. The percentage of fruit with silvering ranged from 0% to 92% during first harvest, 1% to 56% during second harvest and from 5% to 35% during third harvest at RAREC, and from 0% to 22% during second and 0% to 15% during third harvest at the on-farm site depending on pepper line. Less fruit silvering developed in lines with no resistance or tolerance to P. capsici. Reports have suggested that phytophthora-resistance is linked to increased silvering in fruit. Silvering in Paladin was 66%, 56%, and 35% compared to only 0%, 1%, and 5% in Camelot (susceptible cultivar) during each harvest at RAREC and was 22% and 15% in Paladin compared to 0% in Camelot at the on-farm site. Interestingly, silvering was lower when pepper lines were grown on high-ridged bare soil beds with overhead irrigation (on-farm site) compared to same pepper lines grown on black plastic mulch with drip irrigation (RAREC).
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Anggraeni, Poppy, Wahyu Sopandi, Septinaningrum Septinaningrum, Ai Hayati, Tursinawati Tursinawati, and Yosi Gumala Yosi Gumala. "Keterampilan Berpikir Kritis Mahasiswa PGSD Melalui Pembelajaran Read-Answer-Discuss-Explain-And Create (RADEC) yang Berorientasi Penyelidikan." Caruban: Jurnal Ilmiah Ilmu Pendidikan Dasar 4, no. 1 (January 8, 2021): 10. http://dx.doi.org/10.33603/cjiipd.v4i1.4398.
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Abstrak. Penelitian ini bertujuan untuk memperoleh gambaran secara komprehensif mengenai keterampilan berpikir kritis siswa yang memperoleh pembelajaran RADEC berorientasi penyelidikan. Metode penelitian yang digunakan yaitu mixed methods, dengan sampel sebanyak 29 orang mahasiswa PGSD. Instrumen yang digunakan yaitu tes keterampilan berpikir kritis mengacu pada 5 aspek Critical Thinking Abilities yang dikembangkan Ennis (2011). Hasil penelitian menunjukkan bahwa keterampilan berpikir kritis mahasiswa PGSD pada materi perkembangbiakan pada tumbuhan melalui pembelajaran RADEC berorientasi penyelidikan memiliki kategori cukup (53,4%). Adapun keterampilan berpikir kritis tertinggi pada aspek the bases for a decision (59,1%) dan persentase terendah pada aspek basic clarification (44,5%). Hasil uji hipotesis menggunakan software SPSS 22 menunjukkan bahwa tidak terdapat perbedaan yang signifikan keterampilan berpikir kritis antara mahasiswa PGSD perempuan dan laki-laki. Namun demikian, nilai rata-rata keterampilan berpikir kritis perempuan (55,3) lebih besar daripada laki-laki (45,8), maka dapat disimpulkan keterampilan berpikir kritis mahasiswa PGSD perempuan lebih tinggi daripada keterampilan berpikir kritis mahasiswa PGSD laki-laki.Kata kunci: Keterampilan berpikir kritis, RADEC, Penyelidikan
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Shetty, Sanjana, Shilpa Pharande, and Naazia Shaikh. "Alternate rapid maxillary expansion and constriction (Alt-Ramec) — A review." IP Journal of Surgery and Allied Sciences 3, no. 2 (August 15, 2021): 30–33. http://dx.doi.org/10.18231/j.jsas.2021.009.
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Treating Class III malocclusion is a challenge for orthodontists. It is best to treat it at growing stage with Dentofacial Orthopedics. Alt-RAMEC protocol was introduced by Liou in the year 2005. It allows for sutural mobilisation by opening and closing the RME screw for 7-9 weeks. Maxillary protraction after the use of Alt-Ramec protocol is an efficient method for early treatment skeletal Class III malocclusion. The objective of this review is to explain to the clinicians a modified and efficient method for treatment of skeletal Class III malocclusion in growing patients.
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Kale, Burak, and Muhammed Hilmi Büyükçavuş. "Comparison of Transversal Effects of Different Expansion Protocols: Alt-RAMEC versus RME." South European Journal of Orthodontics and Dentofacial Research 7, no. 2 (January 11, 2021): 43–48. http://dx.doi.org/10.5937/sejodr7-27547.
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Abstract
Objectives
The aim of this study is evaluate the transversal effects of the Alt-RAMEC(Alternate Rapid Maxillary Expansion and Constriction) protocol on both craniofacial and dentoalveolar structures and to compare the transversal effects of the RME(Rapid Maxillary Expansion) protocol.
Materials and Methods
In our archive, selected patients were divided into two groups. Group 1 included 22 patients(12boys,10girls, mean age 11.61±2.11years) who had been treated with 5 weeks of Alt-RAMEC. Group 2 comprised 21 patients(11boys,10girls, mean age 11.66±1.23years) who had been treated with 1 week of RME. Transversal measurements were also performed on the study models pre-(T0) and post-treatment(T1) with digital caliper. Internasal, interzygomatic, interjugular and intergonial width measurements were made on posteroanterior radiographs. The initial measurements and the mean changes within the groups were analysed using a student’s t test.
Results
According to the results of the study, there was no statistically significant difference between the groups in terms of chronological age, gender distribution and initial values. The expansion protocols showed a statistically significant increase in the widths of intercanine, interpremolar, intermolar and alveolar base widths in the maxilla(p<0.05). No statistically significant changes were observed in both groups(p>0.05) in mandible. The changes in maxillary intercanine, interpremolar widths between the two groups were statistically significant(p<0.05). In the posteroanterior measurements, only statistically significant difference was found between the groups in internasal width(p<0.05).
Conclusions
Alt-RAMEC and RME protocols are effective treatment protocols for correction of transverse deficiency in growing patients. 5-weeks Alt-RAMEC protocol significantly increased intercanine and interpremolar widths compared to 1-week RME.
Clinical Relevance
Since there are no studies in the literature comparing the effects of two different expansion protocols in the transverse direction, this is both the first. Most importantly, clinicians will see which of these two protocols is more singular in the treatment of transversal problems.
Keywords: RME, Alt-RAMEC, tranversal measurements
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Kale, Burak, and Muhammed Hilmi Büyükçavuş. "Comparison of Transversal Effects of Different Expansion Protocols: Alt-RAMEC versus RME." South European Journal of Orthodontics and Dentofacial Research 7, no. 2 (January 11, 2021): 43–48. http://dx.doi.org/10.5937/sejodr7-27547.
Full textAbstract:
Abstract
Objectives
The aim of this study is evaluate the transversal effects of the Alt-RAMEC(Alternate Rapid Maxillary Expansion and Constriction) protocol on both craniofacial and dentoalveolar structures and to compare the transversal effects of the RME(Rapid Maxillary Expansion) protocol.
Materials and Methods
In our archive, selected patients were divided into two groups. Group 1 included 22 patients(12boys,10girls, mean age 11.61±2.11years) who had been treated with 5 weeks of Alt-RAMEC. Group 2 comprised 21 patients(11boys,10girls, mean age 11.66±1.23years) who had been treated with 1 week of RME. Transversal measurements were also performed on the study models pre-(T0) and post-treatment(T1) with digital caliper. Internasal, interzygomatic, interjugular and intergonial width measurements were made on posteroanterior radiographs. The initial measurements and the mean changes within the groups were analysed using a student’s t test.
Results
According to the results of the study, there was no statistically significant difference between the groups in terms of chronological age, gender distribution and initial values. The expansion protocols showed a statistically significant increase in the widths of intercanine, interpremolar, intermolar and alveolar base widths in the maxilla(p<0.05). No statistically significant changes were observed in both groups(p>0.05) in mandible. The changes in maxillary intercanine, interpremolar widths between the two groups were statistically significant(p<0.05). In the posteroanterior measurements, only statistically significant difference was found between the groups in internasal width(p<0.05).
Conclusions
Alt-RAMEC and RME protocols are effective treatment protocols for correction of transverse deficiency in growing patients. 5-weeks Alt-RAMEC protocol significantly increased intercanine and interpremolar widths compared to 1-week RME.
Clinical Relevance
Since there are no studies in the literature comparing the effects of two different expansion protocols in the transverse direction, this is both the first. Most importantly, clinicians will see which of these two protocols is more singular in the treatment of transversal problems.
Keywords: RME, Alt-RAMEC, tranversal measurements
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Romero de Cea, Carmela Donis. "Análisis comparativo del desajuste de dos tipos de bases de transferencia para prótesis completa." Crea Ciencia Revista Científica 13, no. 2 (June 28, 2021): 12–23. http://dx.doi.org/10.5377/creaciencia.v13i2.11750.
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El ajuste de bases de transferencia a los tejidos bucales desempeña un papel crucial en la construcción de prótesis completa, garantizando que la rehabilitación cumpla sus funciones en forma satisfactoria. Las bases, fabricadas generalmente de resina acrílica de auto curado (RAAC), sufren deformación desde su fabricación hasta su utilización en la boca. Materiales alternativos como policloruro de vinilo (PVC) pueden utilizarse, aunque pocas facultades de Odontología lo incluyen en sus protocolos. El propósito de este estudio fue comparar el desajuste de bases de transferencia de RAAC con las de PVC, para lo cual, fueron construidas 20 bases de RAAC y 20 de PVC sobre 40 modelos de yeso de tipodontos edéntulos, según protocolo de la Facultad de Odontología de la Universidad Evangélica de El Salvador. El desajuste fue medido en el área central del post-dam a 24, 72 y 168 horas de confección, escaneando los modelos y sus bases. Los datos recogidos de imágenes STL fueron analizados con el programa SPSS 25. La prueba T para muestras independientes con valor de p= 0.002 demostró diferencias estadísticamente significativas, encontrando un mayor desajuste en las bases de RAAC de 0,47120 mms. comparado con 0,38288 en las de PVC rechazando la hipótesis nula de igualdad de desajuste. Al comparar grupos por período de tiempo, el de 24 horas no tuvo diferencias estadísticamente significativas, no así en 72 y 168 horas, cuyas diferencias son significativas con mayor desajuste en las bases de RAAC
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Pithon, Matheus Melo, Nathalia de Lima Santos, Camila Rangel Barreto dos Santos, Felipe Carvalho Souza Baião, Murilo Costa Rangel Pinheiro, Manoel Matos Neto, Ianderlei Andrade Souza, and Rafael Pereira de Paula. "Is alternate rapid maxillary expansion and constriction an effective protocol in the treatment of Class III malocclusion? A systematic review." Dental Press Journal of Orthodontics 21, no. 6 (December 2016): 34–42. http://dx.doi.org/10.1590/2177-6709.21.6.034-042.oar.
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ABSTRACT Introduction: the treatment of Class III malocclusion in early age is one of the greatest challenges for orthodontists, and the establishment of more effective treatment method is a constant concern for these professionals. Thus, the objective of this systematic review is to verify the effectiveness of the therapy protocol for alternate rapid maxillary expansion and constriction (Alt-RAMEC) in the early treatment of Class III malocclusion. Methods: searches were performed in the following electronic databases: Cochrane Library, Medline (EBSCO and PubMed), SciELO, LILACS and Scopus. The following inclusion criteria were used: in vivo studies conducted with early intervention (patient in craniofacial development phase) with the use of the Alt-RAMEC protocol. Reviews, case reports, editorials, and studies with syndromic patients or under use of systemic drug were excluded. Duplicates were also excluded. The studies were assessed for methodological quality using the Cochrane tool for assessment of risk of bias, and classified as high or low risk of bias. Results: 53 articles were found. Duplicates exclusion was thus performed and 35 articles remained. After inclusion analysis, only 5 matched the criteria. Two articles were classified as low risk of bias and three as high risk of bias. It was observed that the Alt-RAMEC enable protraction in less time and with better results, promoting greater effectiveness in the protraction treatment of Class III malocclusion. Conclusions: Although there is positive evidence of the effectiveness of early treatment with the Alt-RAMEC protocol in patients with Class III malocclusion, further studies are needed to confirm its effectiveness using long-term methodology.
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Celikoglu, Mevlut, and Muhammet Hilmi Buyukcavus. "Changes in pharyngeal airway dimensions and hyoid bone position after maxillary protraction with different alternate rapid maxillary expansion and construction protocols: A prospective clinical study." Angle Orthodontist 87, no. 4 (January 31, 2016): 519–25. http://dx.doi.org/10.2319/082316-632.1.
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ABSTRACT Objective: To evaluate the changes in pharyngeal airway dimensions and the position of the hyoid bone after maxillary protraction with different alternate rapid maxillary expansion and construction (Alt-RAMEC) protocols in patients with skeletal class III malocclusion as a result of maxillary retrusion. Material and Methods: The patients with skeletal class III malocclusions were consecutively divided into two groups. Group 1 consisted of 17 patients (11 boys and 6 girls, mean age 11.31 ± 1.71 years) who had the Alt-RAMEC protocol for 5 weeks, and group 2 consisted of 17 patients (10 boys and 7 girls, mean age 11.64 ± 1.24 years) who had the Alt-RAMEC procedure for 9 weeks. In this study, 4 angular and 13 linear measurements were performed to evaluate the skeletal and pharyngeal airway changes that occurred after maxillary protraction. Results: A significant increase in the maxillary growth, inhabitation of mandibular growth, and clockwise rotation of the mandible caused the improvement of the maxillo-mandibular relationship in both groups. Those changes caused a significant increase in the upper pharyngeal airway dimension (P < .01) and affected the vertical position of the hyoid bone in both groups (P < .05 and P < .01, respectively). However, changes that occurred in both groups were found to be similar for all airway variables (P > .05). Conclusion: Upper pharyngeal dimension and vertical position of the hyoid bone were affected by the maxillary protraction with different Alt-RAMEC protocols. There were no statistically significant differences between the groups.
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Maryani, Neneng, and Karin Nurseptiani. "Meningkatkan Minat Belajar Bahasa Indonesia dengan Membandingkan Model Pembelajaran RADEC dan Model Pembelajaran Konvensional." MADROSATUNA : Jurnal Pendidikan Guru Madrasah Ibtidaiyah 2, no. 2 (December 20, 2019): 13–19. http://dx.doi.org/10.47971/mjpgmi.v2i2.127.
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This research is based on field findings, namely low interest in learning Indonesian, lack of teacher initiative to use varied learning models that cause students to become bored in following the learning process in Indonesian subjects. The purpose of this study is to find out the increased interest in learning Indonesian by comparing the RADEC (Read, Answer, Discuss, Explain, and Create) learning models and conventional learning. The research method used was Nonequivalent Control Group Design with a population of 173 students, and two sample classes namely class V as an experimental class totaling 28 students and class VI as a control class totaling 37 students. From the results by statistical data using SPSS version 24.0 for windows after the data are declared normally distributed and come from homogeneous samples through normality and homogeneity tests, it is known that the results of hypothesis testing using the Compare Means test with Independent Samples Test obtained sig = 0,000. Because the significance <0.05, it can be concluded that Ho is rejected, which means "There is a difference in the increase in interest in learning Indonesian by using the RADEC learning model compared to using the conventional model in SD Negeri Sukamaju, Pagerageung District, Tasikmalaya District". The score is in the interval 66.4 -70.1. Based on this, it can be concluded that the implementation of the RADEC learning model is quite successful in increasing interest in learning Indonesian compared to using conventional models. Suggestions that can be recommended based on the findings of this study include expected to be able to develop RADEC learning models that are collaborated with other learning techniques as an innovation to increase learning interest.
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Setiawan, Dadan, Wahyu Sopandi, and Tatat Hartati. "Kemampuan menulis teks eksplanasi dan penguasaan konsep siswa sekolah dasar melalui implementasi model pembelajaran RADEC." Premiere Educandum : Jurnal Pendidikan Dasar dan Pembelajaran 9, no. 2 (December 18, 2019): 130. http://dx.doi.org/10.25273/pe.v9i2.4922.
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<p>Meningkatkan kemampuan penjelasan ilmiah dan penguasaan siswa terhadap materi pembelajaran adalah salah satu tujuan utama dalam pendidikan. Tujuan dari penelitian ini adalah untuk mendeskripsikan kemampuan menulis teks eksplanasi dan penguasaan konsep siswa melalui implementasi model pembelajaran Read, Answer, Disscuss, Explain, and Create (RADEC). Metode penelitian yang digunakan dalam penelitian ini adalah metode kuasi eksperimen. Jumlah Partisipan dalam penelitian ini sebanyak 38 siswa. Data dikumpulkan menggunakan tes kemampuan menulis dan penguasaan konsep. Data dianalisis melalui uji normalitas, homogenitas dan uji t menggunakan program SPSS versi 20.0 for windows. Berdasarkan hasil penelitian, diperoleh hasil bahwa skor prates kemampuan menulis siswa sebesar 48,1 dan skor pascates sebesar 68,9. Berdasarkan hasil uji t kemampuan menulissiswa diketahui bahwa p=0,00˂0,05. Dengan demikian dapat ditafsirkan bahwa kemampuan menulis teks eksplanasi siswa mengalami peningkatan setelah diberikan pembelajaran dengan model RADEC. Sementara pada penguasaan konsep siswa diperoleh hasil bahwa skor prates siswa sebesar 36,9 dan skor pascates sebesar 78,5. Kemudiandari hasil uji t diketahui bahwa p=0,00˂0,05 artinya penguasaan konsep teks eksplanasi siswa juga mengalami peningkatan secara signifikan setelah diberikan pembelajaran melalui model RADEC.</p>
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Rice, K. L., P. G. Duane, S. L. Archer, D. P. Gilboe, and D. E. Niewoehner. "H2O2 injury causes Ca(2+)-dependent and -independent hydrolysis of phosphatidylcholine in alveolar epithelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 263, no. 4 (October 1, 1992): L430—L438. http://dx.doi.org/10.1152/ajplung.1992.263.4.l430.
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Oxidants may play a central role in the pathogenesis of adult respiratory distress syndrome, and phospholipase activation is a potential mechanism of oxidant-induced injury of alveolar epithelial cells. Studies were performed in rat alveolar type II epithelial cells (RAEC) after 3 days in culture. As measured by 51Cr and lactate dehydrogenase release, H2O2 caused time- and dose-dependent cytotoxicity to RAEC. RAEC phospholipids labeled with [14C]-stearic acid ([14C]SA) and [3H]arachidonic acid ([3H]AA) released free fatty acids in response to H2O2 in a manner that closely paralleled the cytotoxicity indexes. Analysis of phospholipid subclasses indicated that phosphatidylcholine was preferentially affected. Analysis for putative products of phospholipase activity revealed significant increases in diacylglycerol and phosphorylcholine, expected products of phospholipase C, as well as significant increases in L-alpha-lysophosphatidylcholine and L-alpha-glycerophosphocholine, expected products of phospholipase A2. Increases in phospholipase D activity were not detected. To determine whether H2O2-stimulated phospholipase activity might be Ca2+ stimulated, RAEC were loaded with fura-2/AM, and changes in intracellular Ca2+ concentrations ([Ca2+]i) were monitored by epifluorescent microscopy. Exposure to H2O2 caused elevations in [Ca2+]i, and the time and dose relationships were consistent with the hypothesis that the release of [14C]SA and [3H]AA is related to changes in cellular Ca2+ concentrations. Additionally, pretreatment with MAPTAM, an intracellular chelator of calcium, partially blocked H2O2-mediated [3H]AA liberation. However, experiments in saponin-permeabilized RAEC, in which [Ca2+]i was strongly buffered by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, indicate that H2O2-induced phospholipase activity also has a Ca(2+)-independent component.(ABSTRACT TRUNCATED AT 250 WORDS)
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Özbilen, Elvan Önem, Hanife Nuray Yılmaz, and Yasemin Bahar Acar. "Does Alt-RAMEC protocol and facemask treatment affect dentoalveolar structures?" Angle Orthodontist 91, no. 5 (April 12, 2021): 626–33. http://dx.doi.org/10.2319/111620-940.1.
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ABSTRACT Objectives To evaluate dentoalveolar changes immediately after the alternate rapid maxillary expansion and constriction (Alt-RAMEC) protocol and facemask (FM) treatment using cone-beam computed tomography images. Materials and Methods Cone-beam computed tomography images of 20 patients (mean age = 9.64 ± 1.3 years) who received the Alt-RAMEC protocol before FM treatment were retrieved in this retrospective study. Dental and alveolar inclinations, buccal and palatal alveolar bone thickness, and buccal and palatal alveolar bone height changes were measured before treatment (T0), after the Alt-RAMEC protocol (T1), and after FM treatment (T2). Measurements for right and left molars were performed separately. The Shapiro-Wilks test was used to assess the conformity of the parameters to the normal distribution. The paired t-test and repeated measures analysis of variance were used for normally distributed data. The Wilcoxon signed-rank test and Friedman test were used for non-normally distributed data. The Bonferroni correction was used to reduce the chances of obtaining false-positive results. Statistical significance was set at P < .05. Results Buccal alveolar bone thickness and alveolar bone inclinations decreased significantly from T1 to T0 and showed no significant change from T2 to T1. The total reduction T2-T0 was statistically significant. The change in palatal alveolar bone thickness was not significant T1-T0 but increased significantly for T2-T1 and T2-T0. Buccal alveolar bone height, palatal alveolar bone height, and molar inclinations increased significantly T1-T0, but there was no significant change T2-T1. The total reduction at T2-T0 was statistically significant. Conclusions The results of this study revealed that the effects of the Alt-RAMEC protocol on dentoalveolar tissues were similar to the changes reported in the literature after rapid palatal expansion.
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Maruf, Aif Saiful, Wawan Wahyu, and Wahyu Sopandi. "Colloidal Learning Design using Radec Model with Stem Approach Based Google Classroom to Develop Student Creativity." Journal of Educational Sciences 4, no. 4 (October 24, 2020): 758. http://dx.doi.org/10.31258/jes.4.4.p.758-765.
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This study aimed to examine the feasibility of a RADEC model of colloidal learning design using the STEM approach based on Google classroom to increase student creativity. The method used was descriptive research. This study involved two experts, one teacher, and three high school students in Class XI. Data was collected through an internal feasibility test, the suitability of the creativity sub-indicator with learning activities, and an external feasibility test carried out with a limited test to 3 high school students. The results showed that the learning design uses the RADEC model with a STEM approach based on Google Classroom that deserved to be used to increase student creativity. From this research it is concluded that this learning design can be used to increase student creativity.
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Racec, P. N., and Ulrich Wulf. "Small-Signal Circuit Elements of MIS-Type Nanostructures." Solid State Phenomena 121-123 (March 2007): 549–52. http://dx.doi.org/10.4028/www.scientific.net/ssp.121-123.549.
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Starting from a mean field calculation for the static capacitance of a MIS-nanostructure with a near back gate [P.N. Racec, E. R. Racec and U. Wulf, Phys. Rev. B 65, 193314, (2002)] we develop an approach to determine the equivalent small-signal circuit. The analyzed system has an open character, taken into account in the Landauer-Büttiker formalism. The Coulomb interaction is treated in Hartree approximation. Consistent with our static calculations we determine the charge-charge correlation function in the random phase approximation to find the ac-admittances. The small-signal circuit consists of a voltage-dependent capacitance and a resistance in series. Beyond a characteristic frequency c ν they become frequency dependent. The characteristic frequency is given by the life time of specific resonance which develops in the system.
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Kamp, D. W., M. M. Dunn, J. S. Sbalchiero, A. M. Knap, and S. A. Weitzman. "Contrasting effects of alveolar macrophages and neutrophils on asbestos-induced pulmonary epithelial cell injury." American Journal of Physiology-Lung Cellular and Molecular Physiology 266, no. 1 (January 1, 1994): L84—L91. http://dx.doi.org/10.1152/ajplung.1994.266.1.l84.
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Pulmonary toxicity from asbestos may be due in part to oxidant-mediated mechanisms. The purpose of this study was to determine whether alveolar macrophages (AM) contribute to asbestos-induced alveolar epithelial cell injury by oxidant-dependent mechanisms similar to that previously described for polymorphonuclear leukocytes (PMN). We assessed 51Cr release from cultured rat alveolar epithelial cells (RAEC) and transformed human pulmonary epithelial-like cell lines (rat L2 and human WI-26: HPEC). Amosite asbestos caused dose-dependent injury to both RAEC and L2 cells after an 18-h incubation period. Rat PMN increased asbestos-induced injury to RAEC (11 vs. 20% 51Cr release). In contrast, rat AM diminished asbestos-induced injury to RAEC and L2 cells by 60-80%. Human monocytes cultured for 72 h also attenuated asbestos-induced HPEC damage. Asbestos stimulated more H2O2 release from PMN than from AM isolated from the same rats (5.3 +/- 0.6 vs. 0.3 +/- 0.1 nmol x 10(6) cells-1 x 2h-1). The protective effect of rat AM, as opposed to PMN, was not due to differences in asbestos-induced toxicity to each cell type, since > 90% of AM and PMN were nonviable after 18 h. Transmission electron microscopy demonstrated comparable uptake of asbestos by AM and PMN after a 2-h incubation period. However, after an 18-h exposure period, the PMN were completely lysed, whereas over 90% of the AM contained fibers, despite morphologic evidence of cytotoxicity. These results demonstrate that AM, unlike PMN, can reduce alveolar epithelial cell injury in this model.(ABSTRACT TRUNCATED AT 250 WORDS)
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Setiawan, Dadan, Tatat Hartati, and Wahyu Sopandi. "EFFECTIVENESS OF CRITICAL MULTILITERATION MODEL WITH RADEC MODEL ON THE ABILITY OF WRITING EXPLANATORY TEXT." EduHumaniora | Jurnal Pendidikan Dasar Kampus Cibiru 12, no. 1 (February 13, 2020): 1–14. http://dx.doi.org/10.17509/eh.v12i1.17445.
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Abstract: Developing students' skill in writing scientific explanation is one of the main goals in education. The purpose of this study is to determine the effectiveness of the critical multi-literation model and the RADEC model on the ability in writing explanatory text of elementary school students. This research is conducted on 5th grade students of SDN 122 Cijawura, Buah Batu, Bandung. The samples used in this study are 39 students in the experimental class 1 that used the critical multi-literation model and 38 students in the experimental class 2 that used the RADEC model. The research method used in this study is a quasi-experimental method with a non-equivalent pre-test and post-test control group design. Based on the results of the study, it is found that the pre-test score in the experimental class 1 is 36.6 and the post-test result is 78. Whereas in the experimental class 2 the pre-test score obtained is 48.1 and the post-test score is 68.9. Furthermore, from the results of the independent sample test, the results of the post-test mean difference test are sig = 0.018, so it can be concluded that there are significant differences in the ability to write explanatory text of students between the experimental class 1 and the experimental class 2. Based on these results, the multi-literation model critical is more effective than the RADEC model in developing the ability in writing explanatory text in elementary school students.
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Whittum, Michelle, Ahmed Aly Hussein, Youssef E. Ahmed, Hijab Khan, Collin Krasowski, Neil B. Huben, Paul R. May, Tomoaki Terakawa, Qiang Li, and Khurshid A. Guru. "Gynecological organ involvement at robot-assisted radical cystectomy in females: Is anterior exenteration necessary?" Canadian Urological Association Journal 12, no. 9 (May 14, 2018): E398–402. http://dx.doi.org/10.5489/cuaj.5086.
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Introduction: We aimed to investigate patient and disease variables associated with gynecological organ invasion in females with bladder cancer at the time of robot-assisted radical cystectomy (RARC).Methods: We conducted a retrospective review of female patients who underwent robot-assisted anterior pelvic exenteration (RAAE) between 2005 and 2016. Patients were divided into two groups: those with gynecological organ involvement at RAAE and those without. Data were reviewed for perioperative and pathological outcomes. Kaplan-Meier method was used to depict survival outcomes. Multivariable stepwise regression analysis was performed to identify predictors of gynecological organ involvement.Results: A total of 118 female patients were identified; 17 (14%) showed evidence of gynecological organ invasion at RAAE. Patients with gynecological organ invasion had more lymphovascular invasion at transurethral resection of bladder tumour (TURBT) (82% vs. 46%; p=0.006), trigonal tumours at TURBT (59% vs. 18%; p=0.001), multifocal disease (65% vs. 33%; p=0.01), pN+ (71% vs. 22%; p<0.001), positive surgical margins (24% vs. 4%; p=0.02), and they less commonly demonstrated pure urothelial carcinoma at TURBT (18% vs. 66%; p<0.001). On multivariate analysis, significant predictors of gynecological organ invasion were pN-positive disease (odds ratio [OR] 6.48; 95% confidence interval [CI] 1.64–25.51; p=0.008), trigonal tumour location (OR 5.72; 95% CI 1.39–23.61; p=0.02), and presence of variant histology (OR 18.52; 95% CI 3.32–103.4; p=0.001).Conclusions: Patients with trigonal tumours, variant histology, and nodal involvement are more likely to have gynecological organ invasion at RAAE. This information may help improve counselling of patients and better identify candidates for gynecological organsparing cystectomy.
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Delaunay, Laurent, and Florence Plantet. "RAAC et ambulatoire : un parcours optimisé." Le Praticien en Anesthésie Réanimation 24, no. 6 (December 2020): 320–23. http://dx.doi.org/10.1016/j.pratan.2020.10.006.
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Raspado, Olivier, and Brigitte Crispin. "La RAAC, du concept au soin." La Revue de l'Infirmière 66, no. 234 (October 2017): 18–20. http://dx.doi.org/10.1016/j.revinf.2017.07.002.
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Meazzini, Maria Costanza, Laura B. Zappia, Chiara Tortora, Luca Autelitano, and Roberto Tintinelli. "Short- and Long-Term Effects of Late Maxillary Advancement With the Liou-Alt-RAMEC Protocol in Unilateral Cleft Lip and Palate." Cleft Palate-Craniofacial Journal 56, no. 2 (April 27, 2018): 159–67. http://dx.doi.org/10.1177/1055665618772395.
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Objective: The objective of this retrospective longitudinal study was to evaluate short- and long-term results of the application of the Liou Alt-RAMEC (alternate rapid maxillary expansion and constriction) technique, a late orthopedic maxillary protraction technique, with intraoral anchorage, in patients with cleft. Materials and Methods: Twenty-six patients with unilateral cleft lip and palate (UCLP) were consecutively treated with the Alt-RAMEC technique. The average age of the patients was 11.7 years (10.3-13.2 years) before protraction and 18.3 years (17.4-21.1 years) at long-term follow-up. A sample of nontreated patients with UCLP was used as a control group. It was matched for sex, skeletal class III, and age (11.3 years). The control sample had records at the end of growth (18.7 years). Results: The sagittal advancement of A-point, after the application of the technique, was 5.7 (2.17) mm. Some mandibular dentoalveolar and positional adaptation was noted. The position of the maxilla was stable in the long term. On the other hand, the UCLP control group showed hardly any growth at the maxillary level during the long-term follow-up period. Conclusion: Our results showed that the Alt-RAMEC technique, performed at the correct time, with a double-hinged expander, followed by class III spring or elastic traction, 24 hours per day, allows for satisfactory maxillary protraction, with, at this stage, apparently stable long-term results. Nevertheless, as only 50% of the patients had long-term follow-up data, we are still unable to predict the percentage of patients which will not eventually need orthognathic surgery.
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Zulfa, Salsabila Indana, Monica Widyaswari, and Ulya Aziza Fitriya. "The Effectiveness of RADEC as a Distance Learning Model to Improve the Understanding of Class XI SHS Students on Dynamic Fluid Materials." Procedia of Social Sciences and Humanities 1 (January 30, 2021): 223–28. http://dx.doi.org/10.21070/pssh.v1i.46.
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This study aims to determine the RADEC learning model's effectiveness in improving understanding of dynamic fluid material to XI students of Senior High School (SHS) in distance learning (distance learning). This study used a quasi-experimental method with a nonequivalent control group design. The research population was all students of XI SHS classes, totalling 154 people. The sampling technique used purposive sampling. The sample is XI-3 class as the control group and XI-4 class as the experimental group. The instrument used was a cognitive test. The data analysis technique used descriptive statistics and inferential statistics. The results showed that the two groups' average value is that the pre-test control group was 58.12, and the post-test was 78.13, while the pre-test and post-test experimental group were 76.72 and 87.19. Thus, it can be concluded that the RADEC learning model is more effective than the conventional learning model.
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Hann, J., H. Wu, A. Gauri, K. Dong, N. Lam, and A. Kirkham. "P063: Identification of emergency department patients for referral to rapid-access addiction services: A retrospective chart review." CJEM 21, S1 (May 2019): S86. http://dx.doi.org/10.1017/cem.2019.254.
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Introduction: Emergency Department (ED) visits related to substance use are rapidly increasing. Despite this, few Canadian EDs have immediate access to addiction medicine specialists or on-site addiction medicine clinics. This study characterized substance-related ED presentations to an urban tertiary care ED and assessed need for an on-site rapid-access addiction clinic (RAAC). Methods: This prospective enrollment, retrospective chart review was conducted from June to August 2018. Adult patients presenting to the ED with a known or suspected substance use disorder were enrolled by any member of their ED care team using a 1-page form. Retrospective chart review of the index ED visit was conducted and the Emergency Department Information System was used to extract information related to the visit. A multivariable logistic regression model was fit to examine factors associated with recommendation for referral to a hypothetical on-site RAAC.This prospective enrollment, retrospective chart review was conducted from June to August 2018. Adult patients presenting to the ED with a known or suspected substance use disorder were enrolled by any member of their ED care team using a 1-page form. Retrospective chart review of the index ED visit was conducted and the Emergency Department Information System was used to extract information related to the visit. A multivariable logistic regression model was fit to examine factors associated with recommendation for referral to a hypothetical on-site RAAC. Results: Of the 557 enrolment forms received, 458 were included in the analysis. 64% of included patients were male and 36% were female, with a median age of 35.0 years. Polysubstance use was seen in 23% of patients, and alcohol was the most common substance indicated (60%), followed by stimulants (32%) and opioids (16%). The median ED length of stay for included patients was 483 minutes, compared to 354 minutes for all-comers discharged from the ED during the study period. 28% of patients had a previous ED visit within 7 days of the index visit, and an additional 17% had a visit in the preceding 30 days. The ED care team indicated ‘Yes’ for RAAC referral from the ED for 66% of patients, for a mean of 4.3 patients referred per day during the study period. Multivariable analysis showed that all substances (except cannabis) correlated to a statistically significant increase in likelihood for indicating ‘Yes’ for RAAC referral from the ED (alcohol, stimulants, opioids, polysubstance; p < 0.05). Patients presenting to the ED with a chief complaint related to substance use were also more likely to be referred (p = 0.01). Conclusion: This retrospective chart review characterized substance-related presentations at a Canadian urban tertiary care ED. Approximately four patients per day would have been referred to an on-site RAAC had one been available. The RAAC model has been implemented in other Canadian hospitals, and collaborating with these sites to begin developing this service would be an important next step.
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Aina, Folayo, Sufian Yousef, and Opeyemi Osanaiye. "RAAC: A bandwidth estimation technique for admission control in MANET." Facta universitatis - series: Electronics and Energetics 32, no. 3 (2019): 463–78. http://dx.doi.org/10.2298/fuee1903463a.
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The widespread of wireless mobile network have increased the demand for its applications. Providing a reliable QoS in wireless medium, especially mobile ad-hoc network (MANET), is quite challenging and remains an ongoing research trend. One of the key issues of MANET is its inability to accurately predict the needed and available resources to avoid interference with already transmitting traffic flow. In this work, we propose a resource allocation and admission control (RAAC) solution. RAAC is an admission control scheme that estimates the available bandwidth needed within a network, using a robust and accurate resource estimation technique. Simulation results obtained show that our proposed scheme for MANET can efficiently estimate the available bandwidth and outperforms other existing approaches for admission control with bandwidth estimation.
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Le Fur, Maélig, and Marjory Dago. "Mise en place d’un protocole de RAAC." La Revue de l'Infirmière 66, no. 234 (October 2017): 28–30. http://dx.doi.org/10.1016/j.revinf.2017.07.006.
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Li, Bing, Chao Zhang, Feng Pang, and Yong Kang. "Reflowed Aqua Ammonia Explosion Pretreatment for Corn Stover." Applied Mechanics and Materials 148-149 (December 2011): 1184–89. http://dx.doi.org/10.4028/www.scientific.net/amm.148-149.1184.
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Abstract: Based on ammonia recycled percolation (ARP) and combined with the advantage of ammonia fiber explosion (AFEX), a set of reflowed aqua ammonia explosion pretreatment (RAAEP) equipment was developed. According to the previous orthogonal experiment experimental results, the optimal pretreatment conditions were at 90°C, 9 min retention time, water to dry corn stover loading of 0.8:1(w/w), and aqua ammonia flow rate is 1.5L/min. The cellulose content of the pretreated corn stover was 50.46 % and the glucan and xylan enzymatic digestibility was 86.45 % and 95.77% respectively. The reflowed aqua ammonia not only caused fiber swelling and an efficient delignification (up to 62.5%) of biomass, but also altered the cellulose crystalline structure. The SEM picture and FTIR spectra confirmed swelling and significant delignification effects of the RAAEP process. The X-ray crystallography data indicated that the rigid structure of corn stover was disrupted with more crystallization fiber being exposed after the pretreatment process, but the crystallinity increased due to the removal of amorphous materials (lignin and hemicelluloses).
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Wulandari, Wulandari, Wawan Wahyu, and Wahyu Sopandi. "Students’ Creativity in Creating Aromatherapy Candle using Petroleum Learning Design with Radec Model." Journal of Educational Sciences 4, no. 4 (October 24, 2020): 813. http://dx.doi.org/10.31258/jes.4.4.p.813-820.
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The purpose of this study was to observe whether the examined learning design can improve students' creativity. at the petroleum lesson by using the examined learning design. This research was conducted in Madrasah Aliyah Negeri 2 Takengon. The preferred samples were three second-grade students, a chemical teacher, and two expert lecturers. In this study, the method was descriptive. as it involved two experts, who were lecturers, a chemical teacher, and three second-grade high school students. The data collections were carried out through external and internal feasibility tests. An internal feasibility test was conducted on the chemistry teacher and two expert lecturers, while an external feasibility test was conducted on the three second-grade students. Based on the results, the score results in almost every RADEC stage with a percentage of 91.6% and categorized as very strong, except for the sub-indicator of development creativity or enriching ideas acquired scores of 83.3%. These results imply that petroleum oil learning design with the RADEC model is applicable in the learning process to develop students’ creativity. students’ creativity could be improved by applying chemical learning that uses this learning design.
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Oliveira, João Cesar Dias, and Rui Campos. "Rede admirável epidural rostral e caudal e suas fontes de suprimento sangüíneo em javali (Sus scrofa scrofa)." Ciência Rural 34, no. 3 (June 2004): 795–802. http://dx.doi.org/10.1590/s0103-84782004000300022.
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Este trabalho visou descrever e sistematizar, no javali, as fontes que supriram as redes admiráveis epidurais rostrais e caudais (RAER e RAEC) responsáveis pela irrigação do encéfalo. Foram coletadas 32 cabeças, das quais 30 foram injetadas com látex 603, e duas com resina odontológica, pelas artérias carótidas comuns. A artéria (A.) carótida comum dividiu-se nas artérias carótidas interna e externa. A A. carótida interna emitiu as artérias: occipital e condilar, ramificando-se na formação da RAER, como sua principal fonte. A A. carótida externa continuou-se como A. maxilar, que emitiu as artérias meníngea média e oftálmica externa, as quais cooperaram com ramos para a RAER. As redes rostrais anastomosaram-se em rede, formando um "H", e delas confluíram as artérias carótidas do cérebro. Cada RAEC foi constituída principalmente pela A. occipital, com cooperação das artérias condilar e vertebral, e originaram a A. basilar.
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Geiger, M., A. Stone, S. N. Mason, K. T. Oldham, and K. S. Guice. "Differential nitric oxide production by microvascular and macrovascular endothelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 273, no. 1 (July 1, 1997): L275—L281. http://dx.doi.org/10.1152/ajplung.1997.273.1.l275.
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Phenotypic heterogeneity among endothelial cell populations may account for important organ-specific behaviors. Experimental evidence suggests that endothelium-derived nitric oxide mediates certain of these unique responses. The purpose of these investigations was to compare rat pulmonary microvascular endothelial cells with pulmonary artery and aortic macrovascular endothelial cells in their ability to generate nitric oxide (NO). Cultures of these microvascular and macrovascular endothelial cells were incubated with interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), and Salmonella typhimurium lipopolysaccharide (LPS) alone or in combination, and nitrite production was measured. Single-agent exposure with IFN-gamma (up to 1,000 U/ml), TNF-alpha (up to 60,000 U/ml), or LPS (up to 500 ng/ml) had little effect on nitrite generation. Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. The maximal response by all endothelial cell types (approximately 15-fold increase in RAEC and 8-fold increase in RLMVEC) was observed with LPS + IFN-gamma. The nitrite generation from rat pulmonary artery endothelial cells was intermediate between RAEC and RLMVEC responses when stimulated with IFN-gamma + LPS or TNF-alpha. Similar patterns of heterogeneous inducible nitric oxide synthase mRNA induction occurred when Northern analysis of specimens from the cultured endothelial cell types was done. These data suggest that phenotypic heterogeneity between these endothelial cell populations is substantial and, by inference, that site-specific NO. generation may occur.
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Papadimitriou, E., V. G. Manolopoulos, G. T. Hayman, M. E. Maragoudakis, B. R. Unsworth, J. W. Fenton, and P. I. Lelkes. "Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells." American Journal of Physiology-Cell Physiology 272, no. 4 (April 1, 1997): C1112—C1122. http://dx.doi.org/10.1152/ajpcell.1997.272.4.c1112.
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We have identified a novel cellular action of thrombin on cultured rat adrenal medullary endothelial cells (RAMEC). Five-minute incubation of RAMEC with physiological concentrations of thrombin (<1 U/ml) caused within 3 h an increase in the basolateral deposition of the extracellular matrix (ECM) proteins fibronectin, laminin, and collagens IV and I, concomitant with a corresponding decrease in the apical release of these proteins into the medium. This shift in vectorial secretion of ECM proteins, quantitated with enzyme-linked immunoassays, was time dependent. Maximal stimulation of ECM protein deposition was observed after incubation of cells with thrombin for 5-15 min. Prolonged exposure (>1 h) to thrombin resulted in loss of proteins from the ECM. Thrombin-stimulated ECM protein deposition exhibited a bell-shaped dose dependence, peaking for all proteins at 0.25 U/ml of thrombin, and was independent of de novo mRNA or protein synthesis. Maximal amounts of deposited proteins increased between 2.5-fold (fibronectin) and 4-fold (collagen I) over baseline values. Similar results were obtained with thrombin receptor agonist peptide (TRAP), proteolytically active gamma-thrombin, and, to a lesser extent, other serine proteases such as trypsin and plasmin. A scrambled TRAP, proteolytically inactive PPACK-thrombin, DIP-thrombin, and type IV collagenase were ineffective. Together, these results suggest that the thrombin effects are mediated by proteolytic activation of the thrombin receptor. Possible involvement of the phospholipase C-signaling pathway in thrombin-mediated ECM protein deposition was also investigated. Inhibition or downregulation of protein kinase C (PKC) and chelation of intracellular or extracellular Ca2+ did not suppress, but rather enhanced, basal and thrombin-stimulated ECM protein deposition. Quantitative differences in augmentation of basolateral deposition by these treatments suggest differential regulatory pathways for individual ECM proteins. Our data indicate that, in cultured RAMEC, short-term activation of the thrombin receptor causes an increase in amounts of deposited ECM protein by a cellular signaling pathway that is independent of PKC activation and/or elevation of intracellular Ca2+.
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Nan, Yong-Shan, Guo-Gang Feng, Yoshihiro Hotta, Kimitoshi Nishiwaki, Yasuhiro Shimada, Atsuko Ishikawa, Nakako Kurimoto, Tatsuro Shigei, and Naohisa Ishikawa. "Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 3 (March 2004): H1027—H1033. http://dx.doi.org/10.1152/ajpheart.00630.2003.
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Previously, in vivo studies showed that neuropeptide Y (NPY) elevates vascular permeability in isolated lung perfusion preparations, possibly through binding to the NPY Y3 receptor. The present study used monolayers in a double-chamber culture method under conditions of normoxia (5% CO2-20% O2-75% N2) or hypoxia (5% CO2-5% O2-90% N2) to test the hypothesis that NPY directly affects rat aortic endothelial cells (RAECs). RAECs were cultured on the base of the upper chamber, into which FITC-labeled albumin was introduced, and permeation into the lower chamber was measured. The RAEC monolayer was treated with 10–8–3 × 10–7 M NPY for 2 h in normoxia or hypoxia. In hypoxia, NPY concentration dependently increased the permeability of the RAEC monolayer, whereas in normoxia no significant change was observed. Peptide YY, NPY Y1, and NPY Y2 receptor agonists and NPY Y1 receptor antagonist exerted no significant effects under hypoxic conditions. NPY-(18–36), an NPY Y3 receptor antagonist, elicited an inhibitory action on the NPY-induced increase in monolayer permeability. Furthermore, neither N-monomethyl-l-arginine, a nitric oxide synthase inhibitor, the bradykinin B2 receptor antagonist FK-3657, nor the vascular endothelial growth factor receptor-coupled tyrosine kinase inhibitor tyrphostin SU-1498, injected into the medium of the upper chamber, affected the NPY-induced permeability changes under hypoxic conditions. The results suggest that the NPY-induced increase in permeability across the RAEC monolayer is closely related to low O2 tension, possibly mediated by direct action on the NPY Y3 receptor expressed on the endothelial cell membrane. Furthermore, this NPY-induced increase is not likely due to nitric oxide, bradykinin, or vascular endothelial growth factor.
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HAUG, Cornelia, Alexandra SCHMID-KOTSAS, Theresia LINDER, Peter M. JEHLE, Max G. BACHEM, Adolf GRUENERT, and Eva ROZDZINSKI. "The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells." Clinical Science 103, s2002 (September 1, 2002): 76S—80S. http://dx.doi.org/10.1042/cs103s076s.
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Several studies have demonstrated that endothelin-1 (ET-1) plays an important pathophysiological role in ischaemic renal failure and drug-induced renal injury, such as cyclosporine A (CsA)- and tacrolimus-associated nephrotoxicity. This study aimed to investigate whether the new immunosuppressive drug mycophenolic acid (MPA), which in contrast with CsA and tacrolimus lacks nephrotoxic side effects, modulates ET-1 synthesis in endothelial cells and renal epithelial cells. ET-1 release by cultured human umbilical vein endothelial cells (HUVEC), human renal artery endothelial cells (RAEC) and rabbit proximal tubule cells was measured with a specific ELISA. ET-1 mRNA expression was investigated by reverse transcription–PCR. MPA (2.5–50µg/ml) induced a significant decrease in ET-1 mRNA expression (minimum 51.8±3.8% of control; P<0.001) in HUVEC and RAEC. After a 48h incubation with MPA (1–50µg/ml), a significant decrease in ET-1 release per culture well (minimum 56.8±1.7%; P<0.001) and DNA content per culture well (minimum 58.7±1.9%; P<0.001) was observed with HUVEC and RAEC, whereas ET-1 release referred to the DNA content in the corresponding culture well did not differ significantly from controls. In rabbit proximal tubule cells, ET-1 release referred to the cell number in the corresponding culture well was also reduced after incubation with MPA (minimum 86.2±2.4%; P<0.05). This study provides evidence that, in contrast with CsA and tacrolimus, MPA does not stimulate ET-1 synthesis. The present results might explain the clinical observation that renal function often improves when CsA or tacrolimus is replaced by mycophenolate mofetil.
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Moravcikova, Dominika, Anna Krizanova, and Lucia Svabova. "Evaluation of the Effectiveness of Selected Slovak Brands on the Principle of DEA Models with the Possibility to Optimise them." Economics and Culture 15, no. 1 (June 1, 2018): 22–34. http://dx.doi.org/10.2478/jec-2018-0003.
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Abstract Nowadays, when marketing and branding change, companies are trying to find new ways to evaluate the effectiveness of their marketing activities as they impact on current and future business results. The main objective of the contribution is to evaluate the effectiveness of decision making unit (DMU) production units in the form of selected Slovak brands through the non-parametric data envelopment analysis (DEA) method. The sample size consists of 10 Slovak brands (Slovenská sporiteľňa, VÚB banka, Tatra banka, ESET, Slovnaft, Matador, Rajec, Sygic, Sedita and Zlatý bažant). Through DEA, we have gained a portfolio of effective and portfolio of ineffective brands operating in Slovakia. Depending on the choice of the DEA model, effective brands included Slovenská sporiteľňa, Sygic, Zlatý Bažant, Rajec and Sedita. Other brands were classified as ineffective. The result for ineffective brands is the creation of archetypal characters that we propose in Results section. The part of Results section is the focus of the businesses of the brands in question on the use of social media, to a larger extent, create a social media voice so that the personality of the brand is reflected in contributions in social media communicating on Facebook, Instagram or Twitter. In contribution, deduction, induction, analysis and marketing research methods were used.
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Hassouna, Raaed. "THE EGYPTIAN GEOID BY THREE INTEGRAL TECHNIQUES Raaed Mohamed Kame1 Hassouna." ERJ. Engineering Research Journal 32, no. 1 (January 1, 2009): 83–88. http://dx.doi.org/10.21608/erjm.2009.69392.
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Sukardi, RR, W. Sopandi, and R. Riandi. "Repackaging RADEC learning model into the online mode in science class." Journal of Physics: Conference Series 1806, no. 1 (March 1, 2021): 012142. http://dx.doi.org/10.1088/1742-6596/1806/1/012142.
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Hemalatha, Thiagarajan, Mitali Tiwari, Chidambaram Balachandran, Bhakthavatsalam Murali Manohar, and Rengarajulu Puvanakrishnan. "Platelet-derived endothelial cell growth factor mediates angiogenesis and antiapoptosis in rat aortic endothelial cells." Biochemistry and Cell Biology 87, no. 6 (December 2009): 883–93. http://dx.doi.org/10.1139/o09-056.
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This study explores the angiogenic and antiapoptotic activities of platelet-derived endothelial cell growth factor (PDECGF) in rat aortic endothelial cells. The effects of PDECGF on rat aortic endothelial cell (RAEC) proliferation, migration, chemotaxis, and tubule formation were investigated in vitro at various concentrations viz., 1, 2, 4, 8, 16, and 32 ng·mL–1 on endothelial cells. Endothelial cells were induced with hypoxic stress and the antiapoptotic effects of PDECGF were analysed by cell survival assay, fluorescence microscopy, cell viability assay, and flow cytometry. The results demonstrated the angiogenic potential of PDECGF on endothelial cells in a dose-dependent manner. PDECGF at 16 and 32 ng·mL–1 increased cell proliferation (>80%), induced cell migration (>4 fold), stimulated chemotaxis (>2 fold), and increased tubule formation (>3 fold) compared with the control. Studies on hypoxic stress revealed the antiapoptotic nature of PDECGF on endothelial cells. PDECGF treatment enhanced cell survival by 14%, as well as cell viability by 13%, and decreased the percentage of apoptotic cells by 13% as demonstrated by fluorescence-activated cell sorter studies (FACS). In conclusion, this study demonstrated the angiogenic and antiapoptotic potentials of PDECGF on RAEC.
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Wang, Wei, Zhaolei Jiang, Rongxin Lu, Hao Liu, Nan Ma, Jie Cai, Min Tang, and Ju Mei. "Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling." Cardiology Research and Practice 2018 (December 11, 2018): 1–7. http://dx.doi.org/10.1155/2018/2603025.
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Introduction. Catheter-based renal denervation (RDN) could reduce cardiac sympathetic nerve activity (SNA) and inhibit atrial fibrillation (AF). However, the reliability is uncertain, because the renal sympathetic nerves are mainly distributed in the adventitial surface of the renal artery. Objective. The aims of this study were to test the hypothesis that renal artery adventitial ablation (RAAA) definitely had the effects of RDN and to study the effects of RDN via renal artery adventitial cryoablation (RAAC) on AF and cardiac neural remodeling. Methods. Twenty beagle canines were randomly assigned to two groups: the left RDN group (LRDN, n=10), which underwent left RDN via RAAC; the Sham group (n=10). After 2 months of postoperative recovery, AF vulnerability, AF duration, and histological examination were performed in both groups. Results. Compared with the Sham group, left stellate ganglion (LSG) tissue fibrosis was increased in the LRDN group. LRDN significantly increased the percentage of TH-negative ganglionic cells and decreased the density of TH-positive nerves in the LSG (P<0.001). Also, the densities of TH-positive nerves and GAP43 immunoreactivity within the left atrium (LA) were significantly decreased in the LRDN group (P<0.05). After LA burst pacing, all 10 canines (100%) could be induced AF in the Sham group, but only 4 of 10 canines (40%) could be induced AF in the LRDN group (P=0.011). The percentage of LA burst stimulation with induced AF was 26.7% (8/30) in the LRDN group, which was significantly decreased compared with that of the Sham group (53.3%, 16/30) (P=0.035). In addition, AF duration was also significantly decreased in the LRDN group (13.3 ± 5.1 s) compared with that of the Sham group (20.3 ± 7.3 s, P=0.024). Conclusions. RDN via RAAC could cause cardiac neural remodeling and effectively inhibit AF inducibility and shorten AF duration. It may be useful in selecting therapeutic approaches for AF patients.
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Bai, Wei, Zheqiong Wu, Somenath Mitra, and Jared M. Brown. "Effects of Multiwalled Carbon Nanotube Surface Modification and Purification on Bovine Serum Albumin Binding and Biological Responses." Journal of Nanomaterials 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/2159537.
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Carboxylation of multiwalled carbon nanotubes (MWCNTs) has been used to improve solubility in aqueous systems and for further functionalization with biologically active moieties for biomedical uses. An important consideration is that oxidation debris is generated during the process of carboxylation, which can be removed by base washing. We hypothesized that surface modification as well as purification by debris removal may alter physicochemical properties of MWCNTs and their ability to bind proteins. We utilized pristine MWCNT, carboxylated MWCNTs (F-MWCNTs), and base-washed carboxylated MWCNTs (BW-F-MWCNTs) to examine formation of a bovine serum albumin (BSA) protein corona and impact on biological responses. We found that carboxylation increased the capability of F-MWCNTs to bind BSA, and base washing further increased this binding. Functionalization increased cellular uptake by rat aortic endothelial cells (RAEC) and mouse macrophages (RAW264.7), while base washing showed results similar to the functionalized analog. Interestingly, BSA binding downregulated mRNA levels of interleukin-6 (IL-6) and heme oxygenase 1 (Hmox1) in RAEC cells but upregulated the expression of IL-6 and Hmox1 in RAW264.7 cells. Overall, our study demonstrated that surface modification as well as further purification impacted the interaction of MWCNTs with proteins and subsequent cellular responses.
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Myers, Stuart I., R. H. Turnage, L. Bartula, B. Kalley, and Y. Meng. "Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release." Prostaglandins, Leukotrienes and Essential Fatty Acids 54, no. 6 (June 1996): 403–9. http://dx.doi.org/10.1016/s0952-3278(96)90023-x.
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Estebe, Jean-Pierre. "Bénéfice de l’opioïde free anesthésie dans un parcours de RAAC." Le Praticien en Anesthésie Réanimation 24, no. 6 (December 2020): 292–96. http://dx.doi.org/10.1016/j.pratan.2020.10.005.
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Nogueira, Mark A., Hyung L. Kim, Pamela Piacente, James L. Mohler, and Khurshid A. Guru. "V1920: Robot Assisted Anterior Exenteration (RAAE): Technique and Case Series." Journal of Urology 177, no. 4S (April 2007): 637. http://dx.doi.org/10.1016/s0022-5347(18)32230-4.
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Wang, Fulong, Jocelyn Jia, Nathaniel Lal, Dahai Zhang, Amy Pei-Ling Chiu, Andrea Wan, Israel Vlodavsky, Bahira Hussein, and Brian Rodrigues. "High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature." Cardiovascular Research 112, no. 3 (December 1, 2016): 656–68. http://dx.doi.org/10.1093/cvr/cvw211.
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Aims The secretion of enzymatically active heparanase (HepA) has been implicated as an essential metabolic adaptation in the heart following diabetes. However, the regulation and function of the enzymatically inactive heparanase (HepL) remain poorly understood. We hypothesized that in response to high glucose (HG) and secretion of HepL from the endothelial cell (EC), HepL uptake and function can protect the cardiomyocyte by modifying its cell death signature. Methods and results HG promoted both HepL and HepA secretion from microvascular (rat heart micro vessel endothelial cells, RHMEC) and macrovascular (rat aortic endothelial cells, RAOEC) EC. However, only RAOEC were capable of HepL reuptake. This occurred through a low-density lipoprotein receptor-related protein 1 (LRP1) dependent mechanism, as LRP1 inhibition using small interfering RNA (siRNA), receptor-associated protein, or an LRP1 neutralizing antibody significantly reduced uptake. In cardiomyocytes, which have a negligible amount of heparanase gene expression, LRP1 also participated in the uptake of HepL. Exogenous addition of HepL to rat cardiomyocytes produced a dramatically altered expression of apoptosis-related genes, and protection against HG and H2O2 induced cell death. Cardiomyocytes from acutely diabetic rats demonstrated a robust increase in LRP1 expression and levels of heparanase, a pro-survival gene signature, and limited evidence of cell death, observations that were not apparent following chronic and progressive diabetes. Conclusion Our results highlight EC-to-cardiomyocyte transfer of heparanase to modulate the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy.
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Itaborahy, Wanderson, and Rachel Itaborahy Costa. "Protocolo Alt-RAMEC modificado para o tratamento precoce da Classe III com o Disjuntor DAFI." Revista Clínica de Ortodontia Dental Press 19, no. 5 (November 10, 2020): 101–14. http://dx.doi.org/10.14436/2675-486x.19.5.101-114.art.
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OBJETIVO: O presente artigo tem como objetivo descrever as etapas do Protocolo Alt-RAMEC modificado para a correção precoce da má oclusão de Classe III, bem como apresentar um caso tratado pela técnica proposta. O Protocolo é indicado para pacientes com Classe III esquelética, por deficiência maxilar, em dentição decídua, mista ou permanente jovem. MÉTODOS: Após a cimentação do Disjuntor DAFI (Disjuntor de Abertura e Fechamento Itaborahy) nos molares superiores, inicia-se a fase de ativação/desativação do expansor. O aparelho consiste em um expansor em leque, com um centro de articulação tipo helicoide, feito com fio de TMA, que mantém o paralelismo da disjunção, e um gancho na região dos caninos, para possibilitar o uso de elásticos extrabucais. Decorridas sete semanas de abertura e fechamento do disjuntor, o uso da máscara de tração reversa tipo Petit é iniciado. Essa deve ser utilizada até se atingir um trespasse horizontal de 3 a 4 mm. Finalizada a protração maxilar, monta-se o nivelamento 4x2, com uso de elásticos cruzados com vetor de Classe III, para manutenção simultânea da relação de Classe I ou II, dependendo de cada caso, e da expansão transversal obtida. A contenção após a fase ortodôntica é indispensável. RESULTADOS: No presente caso clínico, houve melhora significativa dos ângulos SNA, ANB e nas medidas Witts e trespasse horizontal, bem como redução da inclinação e protrusão dos incisivos superiores e inferiores. CONCLUSÃO: Conclui-se que o Protocolo Alt-RAMEC modificado é uma terapia eficaz e minimamente invasiva para tratamento da Classe III em crianças.
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McLeod, Margaret. "Culturally Diverse Malayan Milieu: Experiences and Perceptions of RAANC Nurses 1955-1960." Collegian 14, no. 3 (January 2007): 27–31. http://dx.doi.org/10.1016/s1322-7696(08)60562-4.
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Dietrich, K. D., R. M. Foumey, R. A. Aubin, and M. C. Paterson. "A rarec-mosRFLP in normal (noncancerous) fibroblasts from two related cancer patients." Nucleic Acids Research 17, no. 3 (1989): 1273. http://dx.doi.org/10.1093/nar/17.3.1273.
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Chawla, Shilpi, Vinh Xuan Nguyen, Carlos P. Guerra Torres, Marian Pavelka, Jan Trusina, and Michal V. Marek. "Wind characteristics recorded at the Czech Carbon Observation System (CzeCOS) site Rajec." EUROPEAN JOURNAL OF ENVIRONMENTAL SCIENCES 8, no. 2 (December 18, 2018): 117–23. http://dx.doi.org/10.14712/23361964.2018.16.
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