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1
Vanheeswijck, Guido. "Robin George Collingwood on Eternal Philosophical Problems." Dialogue 40, no. 3 (2001): 555–70. http://dx.doi.org/10.1017/s0012217300018928.
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RÉSUMÉR. G. Collingwood a-t-il rejeté, après 1933, l'existence de problèmes éternels en philosophie? En me référant à son œuvre complète (aux manuscrits comme aux écrits publiés), je voudrais montrer que cette question doit recevoir une réponse négative. J'essaie d'expliquer, d'abord, pourquoi Collingwood recourt, dans An Autobiography et An Essay on Metaphysics, à une terminologie un peu curieuse et même parfois trompeuse, qui a donné prise à l'interprétation selon laquelle le dernier Collingwood répudiait l'existence de problèmes éternels en philosophie. Deuxièmement, mon intention est de rendre manifeste que pour Collingwood—qui se considérait lui-même, au milieu des années trente, comme un «idéaliste objectif»—les questions philosophiques sont à la fois historiques et éternelles.
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Allen, Edward. "Relation Between Two Income Inequality Measures: The Gini coefficient and the Robin Hood Index." WSEAS TRANSACTIONS ON BUSINESS AND ECONOMICS 19 (March 8, 2022): 760–70. http://dx.doi.org/10.37394/23207.2022.19.67.
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The objective of this investigation is to study the relation between two common measures of income inequality, the Gini coefficient and the Robin Hood index. An approximate formula for the Robin Hood index in terms of the Gini coefficient is developed from 100,000 Lorenz curves that are randomly generated based on 100 twenty-parameter families of income distributions. The approximate formula is tested against Robin Hood indexes of commonly-used one-parameter Lorenz curves, income data of several countries, and reported results of Robin Hood indexes. The approximate formula is also tested against results of a stochastic income-wealth model that is introduced in the present investigation. The formula is useful conceptually in understanding why Gini coefficients and Robin Hood indexes are correlated in distribution data and is useful practically in providing accurate estimates of Robin Hood indexes when Gini coefficients are known. The continuous piecewise-linear approximation is generally within 5% of standard one-parameter Lorenz curves and income distribution data and has the form: R ≈ 0.74G for 0 ⩽ G ⩽ 0.5, R ≈ 0.37+0.90(G-0.5) for $$0.5 ⩽ G ⩽ 0.8 and $$ R ≈ 0.64 + 1.26 (G- 0.8) for 0.8 ⩽ G ⩽ 0.95$$ where R is the Robin Hood index and G is the Gini coefficient.
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Allers, Eugene, U. A. Botha, O. A. Betancourt, B. Chiliza, Helen Clark, J. Dill, Robin Emsley, et al. "The 15th Biannual National Congress of the South African Society of Psychiatrists, 10-14 August 2008, Fancourt, George, W Cape." South African Journal of Psychiatry 14, no. 3 (August 1, 2008): 18. http://dx.doi.org/10.4102/sajpsychiatry.v14i3.165.
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<p><strong>1. How can we maintain a sustainable private practice in the current political and economic climate?</strong></p><p>Eugene Allers</p><p><strong>2. SASOP Clinical guidelines, protocols and algorithms: Development of treatment guidelines for bipolar mood disorder and major depression</strong></p><p> Eugene Allers, Margaret Nair, Gerhard Grobler</p><p><strong>3. The revolving door phenomenon in psychiatry: Comparing low-frequency and high-frequency users of psychiatric inpatient services in a developing country</strong></p><p>U A Botha, P Oosthuien, L Koen, J A Joska, J Parker, N Horn</p><p><strong>4. Neurophysiology of emotion and senses - The interface between psyche and soma</strong></p><p>Eugene Allers</p><p><strong>5. Suicide prevention: From and beyond the psychiatrist's hands</strong></p><p>O Alonso Betanourt, M Morales Herrera</p><p><strong>6. Treatment of first-episod psychosis: Efficacy and toleabilty of a long-acting typical antipsychotic </strong></p><p>B Chiliza, R Schoeman, R Emsey, P Oosthuizen, L KOen, D Niehaus, S Hawkridge</p><p><strong>7. Treatment of attention deficit hyperactivity disorder in the young child</strong></p><p>Helen Clark</p><p><strong>8. Holistic/ Alternative treatment in psychiatry: The value of indigenous knowledge systems in cllaboration with moral, ethical and religious approaches in the military services</strong></p><p>J Dill</p><p><strong>9. Treating Schizophrenia: Have we got it wrong?</strong></p><p>Robin Emsley</p><p><strong>10.Terminal questions in the elderly</strong></p><p>Mike Ewart Smith</p><p><strong>11. Mental Health Policy development and implementation in Ghana, South Africa, Uganda and Zambia</strong></p><p>Alan J Flisher, Crick Lund, Michelle Frank, Arvin Bhana, Victor Doku, Natalie Drew, Fred N Kigozi, Martin Knapp, Mayeh Omar, Inge Petersen, Andrew Green andthe MHaPP Research Programme Consortium</p><p><strong>12. What indicators should be used to monitor progress in scaling uo services for people with mental disorders?</strong></p><p>Lancet Global Mental Health Group (Alan J Flisher, Dan Chisholm, Crick Lund, Vikram Patel, Shokhar Saxena, Graham Thornicroft, Mark Tomlinson)</p><p><strong>13. Does unipolar mania merit research in South Africa? A look at the literature</strong></p><p>Christoffel Grobler</p><p><strong>14. Revisiting the Cartesian duality of mind and body</strong></p><p>Oye Gureje</p><p><strong>15. Child and adolescent psychopharmacology: Current trends and complexities</strong></p><p>S M Hawkridge</p><p><strong>16. Integrating mental illness, suicide and religion</strong></p><p>Volker Hitzeroth</p><p><strong>17. Cost of acute inpatient mental health care in a 72-hour assessment uniy</strong></p><p>A B R Janse van Rensburg, W Jassat</p><p><strong>18. Management of Schizophrenia according to South African standard treatment guidelines</strong></p><p>A B R Janse van Rensburg</p><p><strong>19. Structural brain imaging in the clinical management of psychiatric illness</strong></p><p>F Y Jeenah</p><p><strong>20. ADHD: Change in symptoms from child to adulthood</strong></p><p>S A Jeeva, A Turgay</p><p><strong>21. HIV-Positive psychiatric patients in antiretrovirals</strong></p><p>G Jonsson, F Y Jeenah, M Y H Moosa</p><p><strong>22. A one year review of patients admitted to tertiary HIV/Neuropsychiatry beds in the Western Cape</strong></p><p>John Joska, Paul Carey, Ian Lewis, Paul Magni, Don Wilson, Dan J Stein</p><p><strong>23. Star'd - Critical review and treatment implications</strong></p><p>Andre Joubert</p><p><strong>24. Options for treatment-resistent depression: Lessons from Star'd; an interactive session</strong></p><p>Andre Joubert</p><p><strong>25. My brain made me do it: How Neuroscience may change the insanity defence</strong></p><p>Sean Kaliski</p><p><strong>26. Child andadolescent mental health services in four African countries</strong></p><p>Sharon Kleintjies, Alan Flisher, Victoruia Campbell-Hall, Arvin Bhana, Phillippa Bird, Victor Doku, Natalie, Drew, Michelle Funk, Andrew Green, Fred Kigozi, Crick Lund, Angela Ofori-Atta, Mayeh Omar, Inge Petersen, Mental Health and Poverty Research Programme Consortium</p><p><strong>27. Individualistic theories of risk behaviour</strong></p><p>Liezl Kramer, Volker Hitzeroth</p><p><strong>28. Development and implementation of mental health poliy and law in South Africa: What is the impact of stigma?</strong></p><p>Ritsuko Kakuma, Sharon Kleintjes, Crick Lund, Alan J Flisher, Paula Goering, MHaPP Research Programme Consortium</p><p><strong>29. Factors contributing to community reintegration of long-term mental health crae users of Weskoppies Hospital</strong></p><p>Carri Lewis, Christa Kruger</p><p><strong>30. Mental health and poverty: A systematic review of the research in low- and middle-income countries</strong></p><p>Crick Lund, Allison Breen, Allan J Flisher, Ritsuko Kakuma, Leslie Swartz, John Joska, Joanne Corrigall, Vikram Patel, MHaPP Research Programe Consortium</p><p><strong>31. The cost of scaling up mental health care in low- and middle-income countries</strong></p><p>Crick Lund, Dan Chishlom, Shekhar Saxena</p><p><strong>32. 'Tikking'Clock: The impact of a methamphetamine epidemic at a psychiatric hospital in the Western Cape</strong></p><p>P Milligan, J S Parker</p><p><strong>33. Durban youth healh-sk behaviour: Prevalence f Violence-related behaviour</strong></p><p>D L Mkize</p><p><strong>34. Profile of morality of patients amitted Weskoppies Psychiatric Hospital in Sout frican over a 5-Year period (2001-2005)</strong></p><p>N M Moola, N Khamker, J L Roos, P Rheeder</p><p><strong>35. One flew over Psychiatry nest</strong></p><p>Leverne Mountany</p><p><strong>36. The ethical relationship betwe psychiatrists and the pharmaceutical indutry</strong></p><p>Margaret G Nair</p><p><strong>37. Developing the frameor of a postgraduate da programme in mental health</strong></p><p>R J Nichol, B de Klerk, M M Nel, G van Zyl, J Hay</p><p><strong>38. An unfolding story: The experience with HIV-ve patients at a Psychiatric Hospital</strong></p><p>J S Parker, P Milligan</p><p><strong>39. Task shifting: A practical strategy for scalingup mental health care in developing countries</strong></p><p>Vikram Patel</p><p><strong>40. Ethics: Informed consent and competency in the elderly</strong></p><p>Willie Pienaar</p><p><strong>41. Confronting ommonmoral dilemmas. Celebrating uncertainty, while in search patient good</strong></p><p>Willie Pienaar</p><p><strong>42. Moral dilemmas in the treatment and repatriation of patients with psychtorders while visiting our country</strong></p><p>Duncan Ian Rodseth</p><p><strong>43. Geriatrics workshop (Psegal symposium): Medico-legal issuess in geriatric psyhiatry</strong></p><p>Felix Potocnik</p><p><strong>44. Brain stimulation techniques - update on recent research</strong></p><p>P J Pretorius</p><p><strong>45. Holistic/Alternative treatments in psychiatry</strong></p><p>T Rangaka, J Dill</p><p><strong>46. Cognitive behaviour therapy and other brief interventions for management of substances</strong></p><p>Solomon Rataemane</p><p><strong>47. A Transtheoretical view of change</strong></p><p>Nathan P Rogerson</p><p><strong>48. Profile of security breaches in longerm mental health care users at Weskoppies Hospital over a 6-month period</strong></p><p>Deleyn Rema, Lindiwe Mthethwa, Christa Kruger</p><p><strong>49. Management of psychogenic and chronic pain - A novel approach</strong></p><p>M S Salduker</p><p><strong>50. Childhood ADHD and bipolar mood disorders: Differences and similarities</strong></p><p>L Scribante</p><p><strong>51. The choice of antipsychotic in HIV-infected patients and psychopharmacocal responses to antipsychotic medication</strong></p><p>Dinesh Singh, Karl Goodkin</p><p><strong>52. Pearls in clinical neuroscience: A teaching column in CNS Spectrums</strong></p><p><strong></strong>Dan J Stein</p><p><strong>53. Urinary Cortisol secretion and traumatics in a cohort of SA Metro policemen A longitudinal study</strong></p><p>Ugash Subramaney</p><p><strong>54. Canabis use in Psychiatric inpatients</strong></p><p><strong></strong>M Talatala, G M Nair, D L Mkize</p><p><strong>55. Pathways to care and treatmt in first and multi-episodepsychosis: Findings fm a developing country</strong></p><p>H S Teh, P P Oosthuizen</p><p><strong>56. Mental disorders in HIV-infected indivat various HIV Treatment sites in South Africa</strong></p><p>Rita Thom</p><p><strong>57. Attendanc ile of long-term mental health care users at ocupational therapy group sessions at Weskoppies Hospital</strong></p><p>Ronel van der Westhuizen, Christa Kruger</p><p><strong>58. Epidemiological patterns of extra-medical drug use in South Africa: Results from the South African stress and health study</strong></p><p>Margaretha S van Heerden, Anna Grimsrud, David Williams, Dan Stein</p><p><strong>59. Persocentred diagnosis: Where d ps and mental disorders fit in the International classificaton of diseases (ICD)?</strong></p><p>Werdie van Staden</p><p><strong>60. What every psychiatrist needs to know about scans</strong></p><p>Herman van Vuuren</p><p><strong>61. Psychiatric morbidity in health care workers withle drug-resistant erulosis (MDR-TB) A case series</strong></p><p>Urvashi Vasant, Dinesh Singh</p><p><strong>62. Association between uetrine artery pulsatility index and antenatal maternal psychological stress</strong></p><p>Bavanisha Vythilingum, Lut Geerts, Annerine Roos, Sheila Faure, Dan J Stein</p><p><strong>63. Approaching the dual diagnosis dilemma</strong></p><p>Lize Weich</p><p><strong>64. Women's mental health: Onset of mood disturbance in midlife - Fact or fiction</strong></p><p>Denise White</p><p><strong>65. Failing or faking: Isses in the fiagnosis and treatment of adult ADHD</strong></p><p>Dora Wynchank</p>
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Borowska-Szerszun, Sylwia. "Representation of Rape in George R. R. Martin’sA Song of Ice and Fireand Robin Hobb’sLiveship Traders." Extrapolation 60, no. 1 (April 2019): 1–22. http://dx.doi.org/10.3828/extr.2019.2.
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Moyal, Ann. "AGuide to the Records of Frank Macfarlane Burnetprepared by G. McCarthy, O. Manhal, L. O'Sullivan and T. Sherratt, 156pp. iIlust.: A Guide to the Records of Albert Lloyd George Rees,prepared by R. Buchanan, G McCarthy, M. Scillio and L. O'Sullivan, 142pp. illust.: A Guide to the Records of Lawrence Percival Coombesprepared by M. Johnson, M. Scillio, A. Taylor, R. Buchanan, L. O'Sullivan and G. McCarthy, 142pp. illust.: A Guide to the Records of Philip Crosbie Morrisonprepared by S. Brash, A. M. Conde, L. Robin, G. McCarthy and T. Sherratt, 178pp. illust. (Australian Science Archives Project, Melbourne, 1993) $20 each, plus $7.50 handling charge." Prometheus 13, no. 1 (June 1995): 140–41. http://dx.doi.org/10.1080/08109029508629205.
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Totik, Vilmos. "R. A. Lorentz, Ed.,George G. Lorentz: Mathematics from Leningrad to Austin." Journal of Approximation Theory 94, no. 3 (September 1998): 498–99. http://dx.doi.org/10.1006/jath.1998.3292.
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Pléh, Csaba. "Beérkezett könyvek." Magyar Pszichológiai Szemle 60, no. 3 (October 1, 2005): 425–27. http://dx.doi.org/10.1556/mpszle.60.2005.3.10.
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Ádám György: A rejtozködo elme. Egy fiziológus széljegyzetei Carpendale, J. I. M. és Müller, U. (eds): Social interaction and the development of knowledge Cloninger, R. C.: Feeling good. The science of well being Dunbar, Robin, Barrett, Louise, Lycett, John: Evolutionary psychology Dunbar, Robin: The human story. A new history of makind's evolution Geary, D. C.: The origin of mind. Evolution of brain, cognition and general intelligence Gedeon Péter, Pál Eszter, Sárkány Mihály, Somlai Péter: Az evolúció elméletei és metaforái a társadalomtudományokban Harré, Rom: Cognitive science: A philosophical introduction Horváth György: Pedagógiai pszichológia Marcus, G.: The birth of the mind. How a tiny number of genes creates the complexities of human thought Solso, R. D.: The psychology of art and the evolution of the conscious brain Wray, A. (ed.): The transition to language
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Berelowitch, Wladimir. "A propos de « soviétologie »." Annales. Histoire, Sciences Sociales 42, no. 5 (October 1987): 1195–207. http://dx.doi.org/10.3406/ahess.1987.283441.
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Dans le numéro de juillet-août des Annales ESC (1985), plusieurs articles et une série de comptes rendus (dont les miens) sont consacrés à l'étude de la Russie, surtout dans sa période soviétique. Certains d'entre eux, particulièrement sous la plume de Régine Robin, Marie-Hélène Mandrillon, Gàbor Rittersporn et Marc Ferro engagent un débat concernant les sources, les méthodes, les concepts des études sur l'URSS. Le ton en est parfois très polémique (dans les comptes rendus de R. Robin et parfois de G. Rittersporn). Par-delà la diversité des analyses et des opinions exprimées, je trouve chez ces auteurs plusieurs idées forces avec lesquelles je me sens en désaccord au moins partiel, et je voudrais en faire part ici. Les voici exposées.
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Mclure, Michael. "A Note on Pareto's “Sunto”." Journal of the History of Economic Thought 27, no. 4 (December 2005): 399–403. http://dx.doi.org/10.1080/10427710500370075.
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The early literature on ordinalism and Vilfredo Pareto's incomplete development of ordinal theory, by John R. Hicks and R. G. D. Allen (1934), Oskar Lange (1934), Hicks (1939), George Stigler (1950), Paul A. Samuelson (1974) and others, referred exclusively to Pareto's more mature French language works: the Manuel d'Économie Politique (1909) or the subsequent encyclopaedia entry entitled “Économie Mathématique” (1911). The related discussion considered whether Pareto was an inconsistent ordinalist, a cardinalist, or confused.
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OULD-HAMMOUDA, AMAR, and RACHAD ZAKI. "Homogenization of a class of elliptic problems with nonlinear boundary conditions in domains with small holes." Carpathian Journal of Mathematics 31, no. 1 (2015): 77–88. http://dx.doi.org/10.37193/cjm.2015.01.09.
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We consider a class of second order elliptic problems in a domain of RN , N > 2, ε-periodically perforated by holes of size r(ε) , with r(ε)/ε → 0 as ε → 0. A nonlinear Robin-type condition is prescribed on the boundary of some holes while on the boundary of the others as well as on the external boundary of the domain, a Dirichlet condition is imposed. We are interested in the asymptotic behavior of the solutions as ε → 0. We use the periodic unfolding method introduced in [Cioranescu, D., Damlamian, A. and Griso, G., Periodic unfolding and homogenization, C. R. Acad. Sci. Paris, Ser. I, 335 (2002), 99–104]. The method allows us to consider second order operators with highly oscillating coefficients and so, to generalize the results of [Cioranescu, D., Donato, P. and Zaki, R., Asymptotic behavior of elliptic problems in perforated domains with nonlinear boundary conditions, Asymptot. Anal., Vol. 53 (2007), No. 4, 209–235].
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Sergeenkova, I. F. "FASCISM IN THE WORKS OF THE AMERICAN HISTORIAN GEORGE MOSSE (1918-1999)." Вестник Удмуртского университета. Социология. Политология. Международные отношения 6, no. 4 (December 24, 2022): 527–44. http://dx.doi.org/10.35634/2587-9030-2022-6-4-527-544.
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The author examines the assessments of fascism presented in the works of the famous American historian G. Mosse. G. Mosse was one of the first to consider fascism as a pan-European phenomenon, emphasizing both the diversity and similarity of various fascist movements. Among the common features that should be considered in national contexts, he singled out: the concept of revolution as a "spiritual revolution", nationalist or racist mysticism, the search for a "third way", revolutionary dynamism and the problem of "taming the revolution", the myth of the new man, the fusion of bourgeois morality and respectability with the ethics of fascism, represented by militant and traditionalist models of courageous men. G. Mosse was one of the first to turn to anthropology to reconstruct the belief system of people who lived in the late XIX and early XX centuries to explain how the Third Reich could become a political reality. G. Mosse pays great attention to the ideological factor, considering the prerequisites of fascism, at a time when the fascist ideology was perceived by historians as complete nonsense. G. Mosse characterizes fascism as a secular religion and turns to the study of the "liturgical elements" of fascism, symbols and myths as means to understand how modern mass movements received popular support. His numerous publications contributed to a paradigm shift in fascist studies. In this sense, he anticipated the cultural orientation of later authors, such famous historians of fascism as S. Payne, R. Griffin and E. Gentile.
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Kaczmarek, Piotr. "WOJNA W IRAKU W ŚWIETLE DOKTRYNY BUSHA." Refleksje. Pismo naukowe studentów i doktorantów WNPiD UAM, no. 13 (October 31, 2018): 41–59. http://dx.doi.org/10.14746/r.2016.1.4.
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The article presents changes in American foreign policy after 11th 2001 and is concerned the George W. Bush’s Middle East policy. The goal of the text is presenting how the Bush doctrine leaded to war in Iraq. After the short introduction about US Middle East policy the text explains fundamental parts of doctrine and describes the most important G. W. Bush speeches and National Security Strategies from 2002 and 2006. This part is dedicated on war on terror, axis of evil and preventive war. The next part try to identify actual and the official and publically stated causes the 2003 invasion of Iraq. The article ends with the analysis the cost of Iraq war.
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Strait, Daniel H. "Christian Mythmakers: C. S. Lewis, Madeleine L 'Engle, J. R. R. Tolkien, George Macdonald, and G. K. Chesterton and Others, by Rolland Hein." Chesterton Review 25, no. 4 (1999): 528–33. http://dx.doi.org/10.5840/chesterton199925414.
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Tatner, P. "Deuterium and oxygen-18 abundance in birds: implications for DLW energetics studies." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 258, no. 3 (March 1, 1990): R804—R812. http://dx.doi.org/10.1152/ajpregu.1990.258.3.r804.
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The doubly labeled water (DLW) technique for measuring energy expenditure may employ one (18O) or two (18O and deuterium) stable isotopes as tracers. These occur naturally in the environment, so when they are used as tracers it is necessary to subtract the background levels. Few studies report data on background concentrations. This work provides such data for a range of avian species. Overall, there was a strong positive correlation (r = 0.63) between the 18O and deuterium concentrations in birds' body water. Variation in the deuterium concentration was less extensive than in the 18O concentration (1:2.7 parts/million). In the European robin, there was a linked, seasonal variation in 18O and deuterium abundance producing high summer and low winter values. Throughout the year, a high individual variability was greater in 18O than in deuterium. A difference between the European robin and the dipper suggests that habitat may also influence background abundance. Investigation of the effect of variation in background abundance on measures of energy expenditure for small passerines (20 g) revealed that employing estimates, instead of direct measurements, had a minor influence over an experimental period of 1 day but could potentially introduce errors as large as 54% over a 2-day period.
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Brumwell, Dom Anselm. "Book Review: Donald R Vance, George Athas, Yael Avrahami and Jonathan G Kline, Biblical Aramaic: A Reader and Handbook." Downside Review 136, no. 2 (January 23, 2018): 135. http://dx.doi.org/10.1177/0012580618754686.
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Phillips, Ronnie J. "James R. Barth and George G. Kaufman, eds.: The First Great Financial Crisis of the 21st Century: A Retrospective." Journal of Economic Issues 50, no. 3 (July 2, 2016): 904–6. http://dx.doi.org/10.1080/00213624.2016.1213600.
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Hamilton, Keith. "G. R. Berridge (Ed.),Tilkidom and the Ottoman Empire: The Letters of Gerald Fitzmaurice to George Lloyd, 1905–1915." Diplomacy & Statecraft 20, no. 2 (August 5, 2009): 347–49. http://dx.doi.org/10.1080/09592290902907619.
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Baker, I. N. "Dynamics of slowly growing entire functions." Bulletin of the Australian Mathematical Society 63, no. 3 (June 2001): 367–77. http://dx.doi.org/10.1017/s000497270001947x.
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Dedicated to George Szekeres on his 90th birthdayFor a transcendental entire function f let M(r) denote the maximum modulus of f(z) for |z| = r. Then A(r) = log M(r)/logr tends to infinity with r. Many properties of transcendental entire functions with sufficiently small A(r) resemble those of polynomials. However the dynamical properties of iterates of such functions may be very different. For instance in the stable set F(f) where the iterates of f form a normal family the components are preperiodic under f in the case of a polynomial; but there are transcendental functions with arbitrarily small A(r) such that F(f) has nonpreperiodic components, so called wandering components, which are bounded rings in which the iterates tend to infinity. One might ask if all small functions are like this.A striking recent result of Bergweiler and Eremenko shows that there are arbitrarily small transcendental entire functions with empty stable set—a thing impossible for polynomials. By extending the technique of Bergweiler and Eremenko, an arbitrarily small transcendental entire function is constructed such that F is nonempty, every component G of F is bounded, simply-connected and the iterates tend to zero in G. Zero belongs to an invariant component of F, so there are no wandering components. The Julia set which is the complement of F is connected and contains a dense subset of “buried’ points which belong to the boundary of no component of F. This bevaviour is impossible for a polynomial.
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Wolf, Klaus. "Machtkalkül und Effizienzstreben. Lloyd George, der Kernbereich der britischen Exekutive und die institutionelle Ausformung eines Mehrebenensystems (1916–1919)." Historische Zeitschrift 308, no. 2 (April 5, 2019): 332–63. http://dx.doi.org/10.1515/hzhz-2019-0008.
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Zusammenfassung Der Essay hinterfragt die weitverbreitete Ansicht, Lloyd George habe bei seinem Amtsantritt 1916 ein premierministerielles Regierungssystem im Vereinigten Königreich eingeführt. Ausgehend von R. A. W. Rhodes’ Definition von „Core Executive“ und S. Piattonis Definition von Mehrebenenpolitik werden die Interaktionen zwischen zentralen Akteuren und die organisatorischen Neuerungen auf gesamt-, sub- und suprastaatlicher Ebene untersucht. Hierdurch gelingt eine Präzisierung des Begriffs „executive prime minister“, den P. Dunleavy und G. W. Jones dazu verwenden, eine Fokussierung auf die vollziehende Gewalt und die Vernachlässigung parlamentarischer Aufgaben zu beschreiben. Angesichts des Ersten Weltkriegs und seiner Folgen gab Lloyd George nicht nur der britischen Exekutive einen leistungsstarken Kernbereich, sondern trieb im Rahmen des British Empire, der alliierten Kriegsführung und der Pariser Friedenskonferenz auch die Institutionalisierung der Steuerungs-, Koordinierungs- und Verhandlungssysteme auf supranationaler Ebene voran. Auf substaatlicher Ebene verschärfte sich indes die Destabilisierung der politischen Ordnung, als das von Lloyd George zur Lösung der Irischen Frage initiierte Partizipationsverfahren scheiterte. Bei den institutionellen Reformen und der Verlagerung politischer Kompetenzen verband er das Ziel gesteigerter Effizienz stets mit dem Wunsch, den Einfluss missliebiger Akteure zu reduzieren. Die grundsätzliche Abhängigkeit des Premiers von der Mitwirkung der Core Executive blieb jedoch auf allen Ebenen bestehen.
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Allen, D. E. "George Bentham's Handbook of the British flora: from controversy to cult." Archives of Natural History 30, no. 2 (October 2003): 224–36. http://dx.doi.org/10.3366/anh.2003.30.2.224.
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George Bentham's Handbook of the British flora sold steadily for almost a century from its publication in 1858 to the relatively inexperienced for whom it was explicitly intended, thanks to full descriptions, dichotomous keys and a lengthy exposition of botanical terminology. But in using it as a vehicle for his controversially broad conception of species, and in aggressively dismissing in the preface the validity of much work by those who, unlike him, had long investigated that flora critically, Bentham provoked lasting hostility to the book among the more advanced. The continued buoyancy of its sales after Bentham's death owed less to limited revisions by Sir Joseph Hooker than to the dying-off of its competitors and the addition of W. H. Fitch's line-drawings of every species, the colouring-in of which became popular as a substitute for collecting specimens. The book's aggregate approach in its taxonomy, however, had a divisive effect on the field botany community, a situation ended in 1952 by the Flora of the British Isles of A. R. Clapham, T. G. Tutin and E. F. Warburg and its subsequent associated volumes.
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Grindrod, Robert. "Book Reviews : AT WORK: AUSTRALIAN EXPERIENCE. Edited by R. Kriegler and G. Stendal. Sydney, George Allen and Unwin, 1984. 228 pp." Australian and New Zealand Journal of Sociology 21, no. 3 (December 1985): 497–98. http://dx.doi.org/10.1177/144078338502100323.
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Dignat-George, Francoise. "Extracellular Vesicles: Overview and Clinical Implications." Blood 132, Supplement 1 (November 29, 2018): SCI—25—SCI—25. http://dx.doi.org/10.1182/blood-2018-99-109472.
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Abstract The release of extracellular vesicles (EVs) is a phenomenon shared by all cell types as a means of communication. Characterization and classification of EVs is challenging and still a matter of debate. However, a general consensus on EVs nomenclatura has been made, on the basis of their size, formation and release mechanisms. EVs has been classified into exosomes, secreted via exocytosis from the late endosome multivesicular bodies, whereas microvesicles (MVs) bud from the plasma membrane and apoptotic bodies are released by cells undergoing apoptosis. Initially regarded as cellular debris, EVs have gained considerable interest in basic sciences and medical research, both as biomarkers and mediators of biological functions. Indeed, EVs carry regulatory molecules including lipid, proteins and different RNA species through the extracellular spaces and deliver these cargos to target cells to modify cellular activity, thereby contributing to both physiological and pathological responses. Because EVs bear markers derived from their parent cells and can be detected in most body fluids, characterization of EVs of different cellular origin is an underestimated source of biological information on cellular activation during disease evolution, and will probably serve as valuable diagnostic and prognostic biomarker in the future. However, the current methods used for the EVs isolation and analysis have several limitations and lack standardization, leading to uncertainties regarding the subtypes of EVs studied and how to interpret the data. After a rapid overview of the current knowledge on the mechanisms of formation, subcellular origin and composition of the different types of EVs, this presentation will focus on microvesicles (MVs). We will first address how their structure/function diversity determines their multifaceted biological functions in coagulation, inflammation, angiogenesis and endothelial dysfunction (ref 1, 2, 3). Secondly, we will summarize the current debate on the different methodologies available for their analysis and quantification in body fluids. A specific attention will be devoted to standardization of sample processing and MVs analysis, and also to recommendations from scientific societies for EVs translational applications as emerging biomarkers measurable in liquid biopsies (ref 4, 5, 6). Finally, focusing on cardiovascular diseases and cancer as emerging field where MVs detection have promising impact to improve patient management, we will illustrate how combination of increasing fundamental knowledge, technological progress and standardization will push MVs towards reliable biomarkers ready for the clinics. 1- Ridger VC, Boulanger CM, Angelillo-Scherrer A, Badimon L, Blanc-Brude O, Bochaton-Piallat ML, Boilard E, Buzas EI, Caporali A, Dignat-George F, Evans PC, Lacroix R, Lutgens E, Ketelhuth DFJ, Nieuwland R, Toti F, Tunon J, Weber C, Hoefer IE. Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. Thromb Haemost. 2017;28;117(7):1296-1316. 2- Todorova D, Simoncini S, Lacroix R, Sabatier F, Dignat-George F. Extracellular Vesicles in Angiogenesis. Circ Res. 2017;12;120(10):1658-1673. 3- Lacroix R, Dubois C, Leroyer AS, Sabatier F, Dignat-George F. Revisited role of microparticles in arterial and venous thrombosis. J Thromb Haemost. 2013;11 Suppl 1:24-35. 4- Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mäger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R. Methodological Guidelines to Study Extracellular Vesicles. Circ Res. 2017;12;120(10):1632-1648. 5-Lacroix R, Judicone C, Mooberry M, Boucekine M, Key NS, Dignat-George F; The ISTH SSC Workshop. Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. J Thromb Haemost. 2013 Apr 2. 6- Cointe S, Judicone C, Robert S, Mooberry MJ, Poncelet P, Wauben M, Nieuwland R, Key NS, Dignat-George F, Lacroix R. Standardization of microparticle enumeration across different flow cytometry platforms: results of a multicenter collaborative workshop. J Thromb Haemost. 2017;15(1):187-193. Disclosures No relevant conflicts of interest to declare.
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Thöne, C. C., and A. de Ugarte Postigo. "OCTOCAM – a New Workhorse Instrument for Transient Follow-up at Gemini South." Proceedings of the International Astronomical Union 14, S339 (November 2017): 181–84. http://dx.doi.org/10.1017/s1743921318002521.
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AbstractOctocam is an 8-channel VIS and NIR imager and spectrograph to be installed at Gemini South in 2022. It provides simultaneous imaging in g’,r’,i’,z,Y,J,H,KS bands or simultaneous spectroscopy at a resolution of ∼4000, together with high time-resolution options. Additional capabilities such as spectropolarimetry or an Integral Field Unit could be added as an upgrade later. These properties makes it very well suited as a follow-up instrument for transient searches. It is planned as a dedicated follow-up instrument for LSST, and will start operations at the same time as the LSST main survey. Octocam was conceived as a consortium consisting of South-West Research Institute in San Antonio, Texas, IAA-CSIC in Granada, FRACTAL SLNE in Madrid, and George Washington University.
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Robbins, Keith. "A History of the Methodist Church in Great Britain, III. Edited by R. Davies, A. R. George and G. Rupp. Pp. viii + 404. London: Epworth Press, 1983. £20. 7162 0387 1." Journal of Ecclesiastical History 38, no. 3 (July 1987): 504. http://dx.doi.org/10.1017/s0022046900025471.
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Livingstone, Frank B. "Human hemoglobin genetics: By George R. Honig and Junius G. Adams III. New York: Springer-Verlag. 1986. xv + 452 pp., figures, tables, index, $76.50 (cloth)." American Journal of Physical Anthropology 73, no. 1 (May 1987): 130–31. http://dx.doi.org/10.1002/ajpa.1330730114.
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Le Gia, Quoc Thong, Michael Clarke, Josef Dick, and David Pye. "Elasticity equations with random domains—the shape derivative approach." ANZIAM Journal 62 (March 9, 2022): C256—C272. http://dx.doi.org/10.21914/anziamj.v62.16120.
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In this work, we discuss elasticity equations on a two-dimensional domain with random boundaries and we apply these equations to modelling human corneas. References R. C. Augustyn, D. Nankivil, A. Mohamed, B. Maceo, F. Pierre, and J.-M. Parel. Human ocular biometry. Exp. Eye Res. 102 (2012), pp. 70–75. doi: 10.1016/j.exer.2012.06.009. F. Ballarin, A. Manzoni, G. Rozza, and S. Salsa. Shape optimization by free-form deformation: Existence results and numerical solution for Stokes flows. J. Sci. Comput. 60.3 (2014), pp. 537–563. doi: 10.1007/s10915-013-9807-8. S. C. Brenner and L.-Y. Sung. Linear finite element methods for planar linear elasticity. Math. Comp. 59 (1992), pp. 321–338. doi: 10.2307/2153060. M. C. Delfour and J.-P. Zolesio. Shapes and geometries. Advances in Design and Control. SIAM, Philadelphia, 2001. doi: 10.1137/1.9780898719826. J. Dick. Higher order scrambled digital nets achieve the optimal rate of the root mean square error for smooth integrands. Ann. Statist. 39.3 (2011), pp. 1372–1398. doi: 10.1214/11-AOS880. J. Dick, F. Y. Kuo, Q. T. Le Gia, and Ch. Schwab. Multilevel higher order QMC Petrov–Galerkin discretization for affine parametric operator equations. SIAM J. Num. Anal. 4.54 (2015), pp. 2541–2568. doi: 10.1137/16M1078690 A. Eilaghi, J. G. Flanagan, I. Tertinegg, C. A. Simmons, G. W. Brodland, and C. R. Ethier. Biaxial testing of human sclera. J. Biomech. 43 (2010), pp. 1696–1701. doi: 10.1016/j.jbiomech.2010.02.031. U. Fares, A. M Otri, M. A. Al-Aqaba, and H. S. Dua. Correlation of central and peripheral corneal thickness in healthy corneas. Cont. Lens Anterior Eye 35 (2012), pp. 39–45. doi: 10.1016/j.clae.2011.07.004. R. N. Gantner and Ch. Schwab. Computational higher order quasi-Monte Carlo integration. Monte Carlo and quasi-Monte Carlo methods. Vol. 163. Springer Proc. Math. Stat. Springer, 2016, pp. 271–288. doi: 10.1007/978-3-319-33507-0_12. on p. C129). H. Harbrecht. Second moment analysis for Robin boundary value problems on random domains. Singular Phenomena and Scaling in Mathematical Models. Ed. by M. Griebel. Springer, 2014, pp. 361–381. doi: 10.1007/978-3-319-00786-1_16. H. Harbrecht, M. Peters, and M. Siebenmorgen. Analysis of the domain mapping method for elliptic diffusion problems on random domains. Numer. Math. 134.4 (2016), pp. 823–856. doi: 10.1007/s00211-016-0791-4. H. Harbrecht, R. Schneider, and Ch. Schwab. Sparse second moment analysis for elliptic problems in stochastic domains. Numer. Math. 109.3 (2008), pp. 385–414. doi: 10.1007/s00211-008-0147-9. R. Hiptmair and J. Li. Shape derivatives in differential forms I: an intrinsic perspective. Ann. Matematica Pura Appl. 192 (2013), pp. 1077–1098. doi: 10.1007/s10231-012-0259-9. C. R. de Lima, L. A. Mello, R. G. Lima, and E. C. N. Silva. Electrical impedance tomography through constrained sequential linear programming: a topology optimization approach. Meas. Sci. Tech. 18.9 (2007), pp. 2847–2858. doi: 10.1088/0957-0233/18/9/014. M. Loeve. Probability theory I. Graduate Texts in Mathematics. Springer-Verlag, 1978. doi: 10.1007/978-1-4684-9464-8. R. Martin, S. Jonuscheit, A. Rio-Cristobal, and M. J. Doughty. Repeatability of Pentacam peripheral corneal thickness measurements. Cont. Lens Anterior Eye 38 (2015), pp. 424–429. doi: 10.1016/j.clae.2015.05.001. R. von Mises. Mechanik der festen Körper im plastisch-deformablen Zustand. Nachrichten von der Gesellschaft der Wissenschaften zu Göttingen. Mathematisch-Physikalische Klasse 1 (1913), pp. 562–592. url: https://eudml.org/doc/58894 F. Orucoglu and E. Toker. Comparative analysis of anterior segment parameters in normal and keratoconic eyes generated by Scheimpflug tomography. J. Ophthalmol., 925414 (2015), pp. 1–8. doi: 10.1155/2015/925414. D. C. Pye. A clinical method for estimating the modulus of elasticity of the human cornea in vivo. PLOS One 15 (2020), pp. 1–19. doi: 10.1371/journal.pone.0224824.
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Semple, Neil. "Wrapped Up In God: A Study of Several Canadian Rivals and Revivalists George A. Rawlyk Burlington, ON: G. R. Welch Co., Limited, 1988. xiv + 169 p." Studies in Religion/Sciences Religieuses 18, no. 4 (December 1989): 506. http://dx.doi.org/10.1177/000842988901800423.
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Batterham, Alan M., and Keith P. George. "Allometric modeling does not determine a dimensionless power function ratio for maximal muscular function." Journal of Applied Physiology 83, no. 6 (December 1, 1997): 2158–66. http://dx.doi.org/10.1152/jappl.1997.83.6.2158.
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Batterham, Alan M., and Keith P. George. Allometric modeling does not determine a dimensionless power function ratio for maximal muscular function. J. Appl. Physiol. 83(6): 2158–2166, 1997.—In the exercise sciences, simple allometry ( y = axb ) is rapidly becoming the method of choice for scaling physiological and human performance data for differences in body size. The purpose of this study is to detail the specific regression diagnostics required to validate such models. The sum (T, in kg) of the “snatch” and “clean-and-jerk” lifts of the medalists from the 1995 Men’s and Women’s World Weightlifting Championships was modeled as a function of body mass (M, in kg). A log-linearized allometric model (ln T = ln a + bln M) yielded a common mass exponent ( b) of 0.47 (95% confidence interval = 0.43–0.51, P < 0.01). However, size-related patterned deviations in the residuals were evident, indicating that the allometric model was poorly specified and that the mass exponent was not size independent. Model respecification revealed that second-order polynomials provided the best fit, supporting previous modeling of weightlifting data (R. G. Sinclair. Can. J. Appl. Sport Sci. 10: 94–98, 1985). The model parameters (means ± SE) were T = (21.48 ± 16.55) + (6.119 ± 0.359)M − (0.022 ± 0.002)M2( R 2 = 0.97) for men and T = (−20.73 ± 24.14) + (5.662 ± 0.722)M − (0.031 ± 0.005)M2( R 2 = 0.92) for women. We conclude that allometric scaling should be applied only when all underlying model assumptions have been rigorously evaluated.
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Scott, Stephen. "Defiant Teens. A Clinician's Manual for Assessment and Family Intervention R. A. Barkley, G. H. Edwards & A. L. Robin New York: The Guilford Press, 1999. pp. 250. £22.95 (pb)." Child Psychology and Psychiatry Review 6, no. 2 (May 2001): 95–99. http://dx.doi.org/10.1017/s1360641701302587.
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Лисанець, Юлія Валеріївна, Олена Миколаївна Бєляєва, and Інеса Віталіївна Роженко. "МОТИВИ ЕПІДЕМІЇ ТА ПАНДЕМІЇ В ЛІТЕРАТУРНО-МЕДИЧНОМУ ДИСКУРСІ ПРОЗИ США." Наукові записки Харківського національного педагогічного університету ім. Г. С. Сковороди "Літературознавство" 1, no. 99 (2022): 69–84. http://dx.doi.org/10.34142/2312-1076.2022.1.99.05.
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The aim of this research is to examine the narrative representation of epidemics in the 20th century U.S. literature, using the methods of narratological analysis and receptive aesthetics. The study relies on the corpus of the 20th century U.S. novels: Scarlet Plague (1912) by Jack London, Earth Abides (1949) by George R. Stewart, I am Legend (1954) by Richard Matheson, The Stand (1978) by Stephen King, Contagion (1996) by Robin Cook, and Darwin’s Radio (1999) by Greg Bear. The aspects of epidemic representation in fiction have been studied using modern literary criticism research in the areas of narratology and receptive aesthetics, which determines the relevance of the present paper. The motif is rooted in the 19th-century Romantic literature (E.A. Poe’s fiction); it acquires further extensive development in the 20th century science fiction, horror, post-apocalyptic (dystopian) and contemporary medical thriller genres. In the second half of the 20th century, by using the motifs of epidemic and pandemic, the writers contemplate upon the issues of science, its capacities, limitations and potential hazards. In the frame of examined novels, the pandemic topos serves as a tool for «reloading» the human population on earth, «resetting» humanity and bringing it back ad fonts. It also acts as a reminder about the dangers of negligence and misuse of research advances. In such a manner, the authors caution the readers against the potential dangers of the 20th-century advances. In the light of COVID-19 pandemic, the study of the literary depiction of this motif in national literatures and different historical periods becomes especially relevant, because it allows us to re-consider this phenomenon and thus to try to help the mankind to learn one's lesson and perhaps avoid similar calamities in the future.
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Antony, A., R. Holland, W. Mokkink, M. A. D’agostino, W. P. Maksymowych, H. Bertheussen, L. Schick, et al. "AB0737 MEASUREMENT PROPERTIES OF RADIOGRAPHIC OUTCOME MEASURES IN PSORIATIC ARTHRITIS: A SYSTEMATIC REVIEW FROM THE GRAPPA-OMERACT INITIATIVE." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1663–64. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2431.
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Background:Structural damage was identified as an important outcome domain in the Psoriatic Arthritis (PsA) Core Domain Set and should be assessed at least once in the development of a new therapeutic.Objectives:To conduct a systematic literature review (SLR) to identify studies addressing the measurement properties (MPs) for ROIs and appraise the evidence through the OMERACT Filter 2.1 Framework Instrument Selection Algorithm (OFISA). [1]Methods:An SLR was conducted in EMBASE and MEDLINE to identify full-text English studies developing or assessing MPs of ROIs in PsA. Determination of eligibility, data extraction and methodology asssessment were performed by 2 reviewers. MPs were rated according to the ‘Provisional Standards’ and assigned a Red/Amber/White/Green (RAWG) rating (Figure 1). [1, 2]Results:3621 references were screened, 531 full-text articles reviewed, and 12 were included (Figure 2). Nine instruments assessing peripheral radiographs and six assessing axial radiographs were identified (Table 1). Three of the nine peripheral radiographic instruments had adequate evidence for reliability and some evidence for construct validity: the modified Steinbrocker, Ratingen, and modified Sharp van der Heijde scores. There was scant evidence for reliability, construct validity and responsiveness for the axial ROIs, compounded by the lack of a standardized definition of axial PsA.Conclusion:This SLR summarizes the MPs of ROIs and identifies relevant knowledge gaps that need to be addressed prior to endorsement of an instrument for the PsA Core Domain Set.References:[1]Richards P and De Wit M, editors. The OMERACT Handbook (March 2019)[2]Mokkink LB and D’Agostino MA. Protocol for performing a systematic review on imaging techniques (unpublished)Figure 1.Criteria for the RAWG RatingFigure 2.PRISMA DiagramTable 1.Summary of Measurement PropertiesROIDomain MatchFeasibilityConstruct ValidityDiscriminationReliabilityResponsivenessInter-raterIntra-raterMeasurement ErrorLongitudinal Construct ValidityClinical Trial DiscriminationThresholds of MeaningOriginal Steinbrocker ScoreA[1]A[1]R[1]Modified Steinbrocker Score#G[2]G[2]A[1]A[2]Modified Larsen ScoreA[1]A[1]A[1]*Ratingen Score#A[1]G[3]G[3]A[3]A[1]mTSS-AA[1]A[1]A[1]mTSS-B#A[1]A[1]A[1]A[1]*mSvdHs#A[2]G[2]G[2]A[1]A[1]*ReXPsAR[0]SPARS#A[1]A[1]A[1]Axial PsA Definition 1MSASSS#A[2]R[0]BASRI - Total#A[2]R[0]PASRI#A[2]R[0]Axial PsA Definition 2MSASSS#A[1]R[1]A[1]A[1]BASRI - Spine#R[1]A[1]A[1]PASRI#A[1]A[1]A[1]Modified NYC#R[1]A[1]RASSS#R[1]A[1]A[1]A = Amber, R = Red, G = Green[Total available studies for synthesis following excluding studies with poor methodology]* RCT data available but no published effect sizes# Feasibility data availableDisclosure of Interests:Anna Antony: None declared, Richard Holland: None declared, Wieneke Mokkink: None declared, Maria-Antonietta d’Agostino: None declared, Walter P Maksymowych Grant/research support from: Received research and/or educational grants from Abbvie, Novartis, Pfizer, UCB, Consultant of: WPM is Chief Medical Officer of CARE Arthritis Limited, has received consultant/participated in advisory boards for Abbvie, Boehringer, Celgene, Eli-Lilly, Galapagos, Gilead, Janssen, Novartis, Pfizer, UCB, Speakers bureau: Received speaker fees from Abbvie, Janssen, Novartis, Pfizer, UCB., Heidi Bertheussen: None declared, Lori Schick: None declared, Niti Goel Shareholder of: UCB and Galapagos, Consultant of: VielaBio, Mallinckrodt, and IMMVention, Alexis Ogdie Grant/research support from: Pfizer, Novartis, Consultant of: Abbvie, Amgen, BMS, Celgene, Corrona, Janssen, Lilly, Pfizer, Novartis, Ana-Maria Orbai Grant/research support from: Abbvie, Eli Lilly and Company, Celgene, Novartis, Janssen, Horizon, Consultant of: Eli Lilly; Janssen; Novartis; Pfizer; UCB. Ana-Maria Orbai was a private consultant or advisor for Sun Pharmaceutical Industries, Inc, not in her capacity as a Johns Hopkins faculty member and was not compensated for this service., Pil Hoejgaard: None declared, Laura C Coates: None declared, Vibeke Strand Consultant of: AbbVie, Amgen, Biogen, Celltrion, Consortium of Rheumatology Researchers of North America, Crescendo Bioscience, Eli Lilly, Genentech/Roche, GlaxoSmithKline, Hospira, Janssen, Merck, Novartis, Pfizer, Regeneron Pharmaceuticals, Inc., Sanofi, UCB, Dafna D Gladman Grant/research support from: AbbVie, Amgen Inc., BMS, Celgene Corporation, Janssen, Novartis, Pfizer, UCB – grant/research support, Consultant of: AbbVie, Amgen Inc., BMS, Celgene Corporation, Janssen, Novartis, Pfizer, UCB – consultant, Robin Christensen: None declared, Ying Ying Leung Speakers bureau: Novartis, Janssen, Eli Lilly, Philip J Mease Grant/research support from: Abbott, Amgen, Biogen Idec, BMS, Celgene Corporation, Eli Lilly, Novartis, Pfizer, Sun Pharmaceutical, UCB – grant/research support, Consultant of: Abbott, Amgen, Biogen Idec, BMS, Celgene Corporation, Eli Lilly, Novartis, Pfizer, Sun Pharmaceutical, UCB – consultant, Speakers bureau: Abbott, Amgen, Biogen Idec, BMS, Eli Lilly, Genentech, Janssen, Pfizer, UCB – speakers bureau, William Tillett Grant/research support from: AbbVie, Celgene, Eli Lilly, Janssen, Novartis, Pfizer Inc, UCB, Consultant of: AbbVie, Amgen, Celgene, Lilly, Janssen, Novartis, MSD, Pfizer Inc, UCB, Speakers bureau: AbbVie, Amgen, Celgene, Lilly, Janssen, Novartis, Pfizer Inc, UCB
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Bradbury, Ian K. "Plants for arid lands by G. E. Wickens, J. R. Goodin and D. V. Field, George Allen and Unwin. 1985. No. of pages: 452. Price: £35.00 (hardback)." Geological Journal 21, no. 2 (April 1986): 219–20. http://dx.doi.org/10.1002/gj.3350210220.
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Tibbetts, Paul E. "Cognitive Neuroscience: The Biology of the Mind. Third Edition. By Michael S. Gazzaniga, Richard B. Ivry, and, George R. Mangun. New York: W. W. Norton . $108.75. xx + 666 p. + G‐1–G‐2 + R‐1–R‐22 + C‐1–C‐8 + I‐1–I‐23; ill.; index. 978‐0‐393‐92795‐5. 2009." Quarterly Review of Biology 84, no. 2 (June 2009): 196–97. http://dx.doi.org/10.1086/603482.
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Szroeter, Jerzy. "Learning and practicing econometrics, William E. Griffiths, R. Carter Hill and George G. Judge. John Wiley, New York, 1993, ISBN 0-471-59951-4, pp. 866. price £19.95." Journal of Applied Econometrics 9, no. 2 (April 1994): 225–26. http://dx.doi.org/10.1002/jae.3950090208.
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Le, Hieu Van, Bien Chu Van, Dinh Thuan Bui, Trung Le Canh, Quang Ho Dinh, and Dinh Nguyen Van Nguyen Van. "Optimization of the ultra-flattened normal dispersion in photonic crystal fibers infiltrated with olive oil for supercontinuum generation." Photonics Letters of Poland 13, no. 1 (March 15, 2021): 1. http://dx.doi.org/10.4302/plp.v13i1.1055.
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This paper proposes a pure silica photonic crystal fiber (PCF), having its core infiltrated with olive oil, which allows achieving an ultra-flattened normal dispersion regime. As a result, the optimization processes allows us to achieve an ultra-flat normal dispersion in the range of over 682 nm within the wavelength range from 1446 to 2128 nm. Besides, the nonlinear coefficient of the selected PCF structure is extremely high (9.54 x 109 W-1.km-1 at 1550 nm). The proposed PCF structure could be very helpful in investigating the supercontinuum generation which has many potential applications in various promising areas such as spectroscopy, medical diagnostics, etc. Full Text: PDF ReferencesJ.M.Dudley, G.Genty and S.Coen, "Supercontinuum generation in photonic crystal fiber", Rev. Mod. Phys. 78(2006). CrossRef T.Udem, R.Holzwarth and T.W.Hänsch, "Optical frequency metrology", Nature 416 233-7(2002). CrossRef S.Moon and D.Y.Kim, "Ultra-high-speed optical coherence tomography with a stretched pulse supercontinuum source", Opt. Express 14 11575-84 (2006). CrossRef G.P.Agrawal. "Chapter 11 - Highly Nonlinear Fibers", Nonlinear Fiber Optics (Oxford: Academic Press 2013) CrossRef V.R.K. Kumar, A.K. George, J.C. Knight, P.S.J. Russell, "Tellurite photonic crystal fiber", Opt. Exp. 11 2641-2645 (2003). CrossRef R. Buczynski, H. T. Bookey, D. Pysz, R. Stepien, I. Kujawa, J. E. McCarthy, A. J. Waddie, A. K. Kar and M. R. Taghizadeh, "Supercontinuum generation up to 2.5 μm in photonic crystal fiber made of lead-bismuth-galate glass", Laser Phys. Lett.7 666-72 (2010). CrossRef F.G.Omenetto, N.A.Wolchover, M.R. Wehner, M. Ross, A. Efimov, A.J. Taylor, V.V.R.K. Kumar, A.K. George, J.C. Knight, N.Y. Joly, P.St.J. Russell, "Spectrally smooth supercontinuum from 350 nm to 3 µm in sub-centimeter lengths of soft-glass photonic crystal fibers.", Opt. Express 14 4928-4934 (2010). CrossRef H. L.Van, V. C. Long, H. T. Nguyen, A. M. Nguyen, R. Buczyński, R. Kasztelanic, "Application of ethanol infiltration for ultra-flattened normal dispersion in fused silica photonic crystal fibers", Laser Physics, 28 115106 (2018). CrossRef J. Pniewski, T. Stefaniuk, H. L. Van, V. C. Long, L. C. Van, R. Kasztelanic, G. Stępniewski, A. Ramaniuk, M. Trippenbach, and R. Buczynski, "Dispersion engineering in nonlinear soft glass photonic crystal fibers infiltrated with liquids", Appl. Opt. 55, 5033-5040(2016). CrossRef H. D. Quang, J. Pniewski, H. L.Van, R. Aleksandr. V. C. Long, B. Krzysztof, D. X. Khoa, K. Mariusz, and R. Buczynski, "Optimization of optical properties of photonic crystal fibers infiltrated with carbon tetrachloride for supercontinuum generation with subnanojoule femtosecond pulses", Applied Optics, Vol. 57, No. 15, 1559-128X (2018). CrossRef M.Chemnitz,M.Gebhardt, C.Gaida, F.Stutzki, J.Kobelke, J.Limpert, A.Tünnermann and M.A. Schmidt, "Hybrid soliton dynamics in liquid-core fibres", Nat. Commun. 8 42 (2017). CrossRef S.Kedenburg, A.Steinmann, R.Hegenbarth, T.Steinle and H.Giessen, "Nonlinear refractive indices of nonlinear liquids: wavelength dependence and influence of retarded response", Appl. Phys. B 117 803-16 (2014). CrossRef E.Sani and A.Dell'Oro, "Spectral optical constants of ethanol and isopropanol from ultraviolet to far infrared", Opt. Mater. 60 137-41 (2016). CrossRef S.T. Wu, "Absorption measurements of liquid crystals in the ultraviolet, visible, and infrared", J. Appl. Phys. 84 4462-4465 (1998). CrossRef Z. Mousavi, B. Ghafary, M.H. Majles Ara, "Fifth- and third- order nonlinear optical responses of olive oil blended with natural turmeric dye using z-scan technique", Journal of Molecular Liquids, https://doi.org/10.1016/j.molliq.2019.04.077 CrossRef Web page: Refractive Index Info: https://refractiveindex.info. CrossRef I. Bodurov, I. Vlaeva, M. Marudova, T. Yovcheva, K. Nikolova, T. Eftimov, V. Plachkova, "Detection of adulteration in olive oils using optical and thermal methods", Bulgarian Chemical Communications, Volume 45, Special Issue B (pp. 81-85) (2013) DirectLink
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Ivarie, R., and J. A. Morris. "Activation of a nonexpressed hypoxanthine phosphoribosyltransferase allele in mutant H23 HeLa cells by agents that inhibit DNA methylation." Molecular and Cellular Biology 6, no. 1 (January 1986): 97–104. http://dx.doi.org/10.1128/mcb.6.1.97-104.1986.
Full textAbstract:
HeLA H23 cells are a mutant female human tumor cell line harboring defective hypoxanthine phosphoribosyltransferase (HPRT; IMP-pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) as a result of a mutation that alters the isoelectric point of the enzyme (G. Milman, E. Lee, G. S. Changas, J. R. McLaughlin, and J. George, Jr., Proc. Natl. Acad. Sci. USA 73:4589-4592, 1976). As shown by Milman et al. and confirmed by us here, rare HAT+ revertants arise spontaneously at 1.9 X 10(-8) frequency and express both mutant and wild-type polypeptides. Thus, the H23 mutant also carries a silent wild-type HPRT allele that is activated in revertants. To test whether the silent allele was activated via hypomethylation of genomic DNA, H23 cells were treated with inhibitors of DNA methylation, and revertants were scored by HAT or azaserine selection. At an optimal dose of 5 microM 5-azacytidine, the reversion frequency was increased about 50-fold when assayed by HAT selection and over 1,000-fold when assayed by azaserine selection. HAT+ and azaserine revertants were heterozygous for HPRT, expressing both wild-type and mutant HPRT polypeptides. Like spontaneous revertants, they contained active HPRT enzyme and were genetically unstable, reverting at about 10(-4) frequency. Similar results were found after treatment with N-methyl-N'-nitro-N-nitrosoguanidine, a DNA-alkylating agent and potent inhibitor of mammalian DNA methylation. By contrast, the DNA-ethylating agent, ethyl methanesulfonate (EMS), did not increase the HAT+ reversion frequency; it did, however, increase the frequency by which H23 revertants heterozygous for HPRT reverted to 6-thioguanine resistance. Of nine EMS revertants, seven lacked HPRT activity and had a substantially reduced expression of the wild-type polypeptide. These observations support the hypothesis that DNA methylation plays an important role in human X-chromosome inactivation and that EMS can inactivate gene expression by promoting enzymatic methylation of genomic DNA as found previously for the prolactin gene in GH3 rat pituitary tumor cells (R. D. Ivarie and J. A. Morris, Proc. Natl. Acad. Sci. USA 79:2967-2970, 1982; R. D. Ivarie, J. A. Morris, and J. A. Martial, Mol. Cell. Biol. 2:179-189, 1982).
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Ivarie, R., and J. A. Morris. "Activation of a nonexpressed hypoxanthine phosphoribosyltransferase allele in mutant H23 HeLa cells by agents that inhibit DNA methylation." Molecular and Cellular Biology 6, no. 1 (January 1986): 97–104. http://dx.doi.org/10.1128/mcb.6.1.97.
Full textAbstract:
HeLA H23 cells are a mutant female human tumor cell line harboring defective hypoxanthine phosphoribosyltransferase (HPRT; IMP-pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) as a result of a mutation that alters the isoelectric point of the enzyme (G. Milman, E. Lee, G. S. Changas, J. R. McLaughlin, and J. George, Jr., Proc. Natl. Acad. Sci. USA 73:4589-4592, 1976). As shown by Milman et al. and confirmed by us here, rare HAT+ revertants arise spontaneously at 1.9 X 10(-8) frequency and express both mutant and wild-type polypeptides. Thus, the H23 mutant also carries a silent wild-type HPRT allele that is activated in revertants. To test whether the silent allele was activated via hypomethylation of genomic DNA, H23 cells were treated with inhibitors of DNA methylation, and revertants were scored by HAT or azaserine selection. At an optimal dose of 5 microM 5-azacytidine, the reversion frequency was increased about 50-fold when assayed by HAT selection and over 1,000-fold when assayed by azaserine selection. HAT+ and azaserine revertants were heterozygous for HPRT, expressing both wild-type and mutant HPRT polypeptides. Like spontaneous revertants, they contained active HPRT enzyme and were genetically unstable, reverting at about 10(-4) frequency. Similar results were found after treatment with N-methyl-N'-nitro-N-nitrosoguanidine, a DNA-alkylating agent and potent inhibitor of mammalian DNA methylation. By contrast, the DNA-ethylating agent, ethyl methanesulfonate (EMS), did not increase the HAT+ reversion frequency; it did, however, increase the frequency by which H23 revertants heterozygous for HPRT reverted to 6-thioguanine resistance. Of nine EMS revertants, seven lacked HPRT activity and had a substantially reduced expression of the wild-type polypeptide. These observations support the hypothesis that DNA methylation plays an important role in human X-chromosome inactivation and that EMS can inactivate gene expression by promoting enzymatic methylation of genomic DNA as found previously for the prolactin gene in GH3 rat pituitary tumor cells (R. D. Ivarie and J. A. Morris, Proc. Natl. Acad. Sci. USA 79:2967-2970, 1982; R. D. Ivarie, J. A. Morris, and J. A. Martial, Mol. Cell. Biol. 2:179-189, 1982).
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KITLV, Redactie. "Book Reviews." New West Indian Guide / Nieuwe West-Indische Gids 61, no. 3-4 (January 1, 1987): 183–210. http://dx.doi.org/10.1163/13822373-90002052.
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-Richard Price, C.G.A. Oldendorp, C.G.A. Oldendorp's history of the Mission of the Evangelical Brethren on the Caribbean Islands of St. Thomas, St. Croix, and St. John. Edited by Johann Jakob Bossard. English edition and translation by Arnold R. Highfield and Vladimir Barac. Ann Arbor MI: Karoma, 1987. xxxv + 737 pp.-Peter J. Wilson, Lawrence E. Fisher, Colonial madness: mental health in the Barbadian social order. New Brunswick, N.J.: Rutgers University Press, 1985. xvi + 215 pp.-George N. Cave, R.B. le Page ,Acts of identity: Creloe-based approaches to language and ethnicity. Cambridge: Cambridge University Press, 1985. x + 275 pp., Andree Tabouret-Keller (eds)-H. Hoetink, Julia G. Crane, Saba silhouettes: life stories from a Caribbean island. Julia G. Crane (ed), New York: Vantage Press, 1987. x + 515 pp.-Sue N. Greene, Anne Walmsley ,Facing the sea: a new anthology from the Caribbean region. London and Kingston: Heinemann, 1986. ix + 151 pp., Nick Caistor, 190 (eds)-Melvin B. Rahming, Mark McWatt, West Indian literature and its social context. Cave Hill, Barbados, Department of English, 1985.-David Barry Gaspar, Rebecca J. Scott, Slave emancipation in Cuba: the transition to free labor, 1860-1899. Princeton, New Jersey: Princeton University Press, 1985. xviii + 319 pp.-Mary Butler, Louis A. Perez Jr., Cuba under the Platt agreement, 1902-1934. Pittsburgh: University of Pittsburgh Press, 1986. xvii + 410 pp.-Ana M. Rodríguez-Ward, Idsa E. Alegria Ortega, La comisión del status de Puerto Rico: su historia y significación. Río Piedras, Puerto Rico: Editorial Universitaria. 1982. ix + 214 pp.-Alain Buffon, Jean Crusol, Changer la Martinique: initiation a l'économie des Antilles. Paris: Editions Caribeennes, 1986. 96 pp.-Klaus de Albuquerque, Bonham C. Richardson, Panama money in Barbados, 1900-1920. Knoxville: University of Tennesse Press, 1985. xiv + 283 pp.-Steven R. Nachman, Marcel Fredericks ,Society and health in Guyana: the sociology of health care in a developing nation. Authors include Janet Fredericks. Durham: Carolina Academic Press, 1986. xv + 173 pp., John Lennon, Paul Mundy (eds)
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Couture, Jocelyne. "The Collected Papers of Bertrand Russell: Cambridge Essays, 1888–1899K. Blackwell, A. Brink, N. Griffin, R. A. Rempel et J. G. Slater, editors London: George Allen & Unwin, 1983. Pp. 554." Dialogue 24, no. 2 (1985): 364–65. http://dx.doi.org/10.1017/s0012217300043274.
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Escott, Timothy R. "Biblical Aramaic: A Reader and Handbook, Donald R. Vance, George Athas, Yael Avrahami and Jonathan G. Kline, Hendrickson Publishers, 2016 (ISBN 978-1-61970-891-4), xxii + 234 pp., hb $29.95." Reviews in Religion & Theology 25, no. 4 (October 2018): 786–89. http://dx.doi.org/10.1111/rirt.13419.
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Makhlin, Igor, Nicholas McAndrew, E. Paul Wileyto, Amy Clark, Robin Holmes, Lisa N. Bottalico, Grace R. Jeschke, et al. "Abstract P2-07-04: Analysis of host inflammatory and estrogen biomarkers in JAKEE: A phase II trial of the JAK inhibitor ruxolitinib in combination with exemestane for estrogen receptor-positive metastatic breast cancer." Cancer Research 82, no. 4_Supplement (February 15, 2022): P2–07–04—P2–07–04. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-07-04.
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Abstract Background: Circulating IL-6, an activator of JAK/STAT signaling, is associated with poor outcomes and aromatase inhibitor (AI) resistance in hormone-receptor positive (HR+) metastatic breast cancer (MBC). We previously presented clinical outcomes of JAKEE, a single arm, phase II, Simon two-stage clinical trial that tested Ruxolitinib (Rux), an oral selective inhibitor of JAK1/2, and exemestane (EXE) in 25 participants (pts) with HR+ MBC that relapsed/progressed on non-steroidal AI (NSAI); specifically, the primary endpoint of safety was met, but there were no complete or partial responses and 6/25 (24%) achieved stable disease (SD) for ≥6 cycles. We investigated whether host circulating inflammatory markers, IL-6 genotypes, and estrogen levels were associated with differential response to therapy.Methods: Responders (R) were defined as having achieved SD≥6 cycles. Flow cytometry was performed on baseline and on-treatment peripheral blood samples to assess downstream CD3+ T-cell phosphoSTAT3 inhibition by Rux. Serum concentrations of C-reactive protein (CRP), IL-6, serum amyloid A (SAA), Estrone (E1) and Estradiol (E2) were measured at baseline and serially on treatment. Sanger sequencing was performed to assess for three functional variants of the IL-6 promoter: −572G>C (rs1800796), −597G>A (rs1800797), and −174G>C (rs1800795), with high-risk polymorphisms being -597G/G and/or -174G/G. Non-parametric median testing was employed to test for differences in circulating markers by response groups given non-normal distribution, with a two-sided alpha of 0.05.Results: The cohort was heavily pre-treated: 28% received ≥2 lines of chemotherapy for MBC and 20% had CNS disease at enrollment. Among 17/25 pts with samples for pharmacodynamic assessment, Rux exhibited a 25% median inhibition (range 0-77%) of phosphoSTAT3. There was no differential effect in R vs non-responders (NR) (median inhibition 20% vs 29%, p=0.15). Frequency of high-risk IL-6 genotypes and distribution of baseline serum CRP, IL-6, SAA, E1 and E2 are depicted in the table. 15/25 (60%) harbored a high-risk IL-6 promoter polymorphism, with no significant difference in frequency between R and NR (50% vs 63%, p=0.65). 19 pts had samples for inflammatory biomarker analysis. 16/19 had baseline CRP≥10mg/L. While median levels of baseline CRP, SAA, and IL-6 were above upper limit of normal, there was no difference between R and NR (table). The proportion of pts with baseline undetectable E1 and E2 were similar between R and NR (E1: 36.9% vs 33.3%, p=1.0, E2: 52.6% vs 50%, p=1.0); notably, a significantly lower proportion with high-risk IL-6 genotype had undetectable baseline E1 (20% vs 60%, p=0.041), while no difference was noted for baseline E2, nor in the % change in E1 or E2 levels from baseline to cycle 4 by responder status.Conclusions: The JAKEE cohort represents an inflamed population with elevated circulating inflammatory markers and a high proportion with high-risk IL-6 genotypes. Examination of host inflammatory markers, IL-6 genotypes and estrogen levels did not reveal a differential response to the combination of Rux and EXE in patients with HR+ MBC that had progressed on prior NSAI. At tolerable dosing, Rux exhibited only a modest inhibition of phosphoSTAT3. Further work is needed to optimize strategies for targeting inflammation and JAK/STAT signaling in HR+ MBC. IL-6 GenotypeFrequencyFrequency by ResponderSignificanceHigh-Risk -174G/G and/or -597G/G15/25 (60%)Non-responder12/19 (63.2%)Responder3/6 (50%)p-value0.56Pretreatment Inflammatory Biomarkers [Upper limit of normal]Median (Range)Median Level by Responder GroupSignificanceCRP [8mg/L]SAA [10mg/L]IL-6 [2pg/mL]24.0 (0.2-146.8)12.8 (2.8-162.5)4.2 (1.8-11.5)Non-responder23.219.84.5Responder24.7 12.42.7p-value0.510.150.15Baseline Estrogen BiomarkersMedian (Range)Non-responderResponderp-valueEstrone (E1) (pg/mL)Estradiol (E2) (pg/mL)79.5.0 (0.2-1039.0)0.2 (0.2-44.1)79.8 0.247.8 4.20.410.91 Citation Format: Igor Makhlin, Nicholas McAndrew, E. Paul Wileyto, Amy Clark, Robin Holmes, Lisa N Bottalico, Grace R Jeschke, Kevin R Fox, Susan M Domcheck, Jennifer M Matro, Angela R Bradbury, Natalie Shih, Michael D Feldman, Elizabeth O Hexner, Jacqueline F Bromberg, Angela DeMichele. Analysis of host inflammatory and estrogen biomarkers in JAKEE: A phase II trial of the JAK inhibitor ruxolitinib in combination with exemestane for estrogen receptor-positive metastatic breast cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-07-04.
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Guan, Raymond, and Aimy Bazylak. "Determining Substrate Oxygen Transport Resistance at Limiting Current Using Pore Network Modelling." ECS Meeting Abstracts MA2022-02, no. 50 (October 9, 2022): 2476. http://dx.doi.org/10.1149/ma2022-02502476mtgabs.
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The polymer electrolyte membrane (PEM) fuel is a promising technology to supplant traditional, greenhouse gas emitting energy conversion devices. However, widespread commercial adoption of the PEM fuel cell is hindered by the high cost of the precious metals required for its catalyst (1). The amount of catalyst required in a PEM fuel cell can be reduced if the reactant (oxygen) is delivered more efficiently to the catalyst. Therefore, previous studies have sought to characterize the mechanisms affecting oxygen transport in PEM fuel cells (2)(3)(4)(5). In past studies, the oxygen transport resistance of a PEM fuel cell was measured at limiting current, and this value was further decomposed into contributions from individual PEM fuel components using empirical modelling. By resolving each PEM fuel cell component’s contribution to oxygen transport resistance, an informed approach can be undertaken to design next generation components with enhanced oxygen transport capabilities. In this study, we employed pore network modelling to quantify the oxygen transport resistance arising from the presence of liquid water within the substrate region of the gas diffusion layer (GDL). First, we captured the operando liquid water distribution within a PEM fuel cell operating at limiting current using synchrotron X-ray radiography. Next, we used a combination of invasion percolation and an in-house water invasion inlet selection algorithm to partially saturate the representative pore network of the substrate and to reproduce the mean water saturation. Finally, we obtained substrate oxygen transport resistance values by performing transport simulations on the partially saturated pore network and compare our findings with the experimental observations. References X. X. Wang, M. T. Swihart, and G. Wu, Nature catalysis, 2, 7 (2019). D. R. Baker, D. A. Caulk, K. C. Neyerlin, and M. W. Murphy, J. Electrochem. Soc., 156, B991 (2009). T. Reshtenko, J. St-Pierre, J. Electrochem. Soc., 161, F1089 (2014) D. Muirhead, R. Banerjee, M. G. George, N. Ge, P. Shrestha, H. Liu, J. Lee, A. Bazylak, Electrochimica Acta, 274 (2018). N. Ge, P. Shrestha, M. Balakrishnan, D. Ouellette, A. K. C. Wong, H. Liu, C. H. Lee, J. K. Lee, A. Bazylak, Electrochimica acta, 328 (2019).
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Mostert, L., W. Bester, T. Jensen, S. Coertze, A. van Hoorn, J. Le Roux, E. Retief, A. Wood, and M. C. Aime. "First Report of Leaf Rust of Blueberry Caused by Thekopsora minima on Vaccinium corymbosum in the Western Cape, South Africa." Plant Disease 94, no. 4 (April 2010): 478. http://dx.doi.org/10.1094/pdis-94-4-0478c.
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Southern highbush blueberry plants (Vaccinium corymbosum interspecific hybrids) showing rust-like symptoms were observed in July 2006 in Porterville in the Western Cape (WC), South Africa. Diseased plants were also found in Villiersdorp and George in the WC in 2007. In 2008, symptoms were observed in George, and in 2009, in all the previous reported areas. Cvs. Bluecrisp, Emerald, Jewel, Sharpblue, and Star were infected. Reddish-to-brown spots appeared on the adaxial surface of leaves and developed into yellow-to-orange erumpent uredinia with pulverulent urediniospores. Uredinia were hypophyllous, dome shaped, 113 to 750 μm wide, and occasionally coalescing. Urediniospores were broadly obovate, sometimes ellipsoidal or pyriform, with yellowish orange content, and measured 19 to 27 × 12 to 20 μm (average 24 × 15 μm, n = 30). Spore walls were echinulate, hyaline, 1 to 1.5 μm thick, and with obscure germ pores. No telia or teliospores were observed. Voucher specimens were lodged in the South African National Fungus Collection in Pretoria (PREM 60245). The isolate was initially identified as Thekopsora minima P. Syd. & Syd., based primarily on the absence of conspicuous ostiolar cells characteristic of Naohidemyces spp. (3). Genomic DNA was extracted from urediniospores. Approximately 1,400 bp were amplified spanning the 5.8S, ITS2, and 28S large subunit of the ribosomal DNA (1). The sequence (GU355675) shared 96% (907 of 942 bp; GenBank AF522180) and 94% (1,014 of 1,047 bp; GenBank DQ354563) similarities in the 28S portion, respectively, to those of Naohidemyces vaccinii (Wint.) Sato, Katsuya et Y. Hiratsuka and Pucciniastrum geoppertianum (Kuehn) Kleb, two of the three known rust species of blueberry (2). Although no sequences of T. minima were available for direct comparison, phylogenetic analyses of the 28S region strongly supported the South African blueberry rust as congeneric with T. guttata (J. Schröt.) P. Syd. & Syd. (GenBank AF426231) and T. symphyti (Bubák) Berndt (GenBank AF26230) (data not shown). Four 6-month-old cv. Sharpblue plants were inoculated with a suspension (approximate final concentration of 1 × 105 spores per ml) of fresh urediniospores in a water solution with 0.05% Tween 20. After incubation at 20°C for 48 h under continuous fluorescent lighting, the plants were grown in a glasshouse (18/25°C night/day temperatures). Identical uredinia and symptoms developed approximately 3 weeks after inoculation on the inoculated plants, but not on two control plants of cv. Sharpblue sprayed with distilled water and kept at the same conditions. The alternate host hemlock (Tsuga spp.) is not endemic to South Africa and not sold as an ornamental plant according to a large conifer nursery. Hosts of T. minima include Gaylussacia baccata, G. frondosa, Lyonia neziki, Menziesia pilosa, Rhododendron canadense, R. canescens, R. lutescens R. ponticum, R. prunifolium, R. viscosum, V. angustifolium var. laevifolium, V. corumbosum, and V. erythrocarpon (3). Visual inspection of possible hosts in the gardens in close proximity of Vaccinium production areas did not show any rust symptoms. To our knowledge, this is the first report of T. minima on blueberries outside of Asia and the United States (2). References: (1) M. C. Aime. Mycoscience 47:112, 2006. (2) D. F. Farr and A. Y. Rossman. Fungal Databases. Systematic Botany and Mycology Laboratory. Online publication. USDA-ARS, 2009. (3) S. Sato et al. Trans. Mycol. Soc. Jpn. 34:47, 1993.
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Dixon, Eryn E., and Owen M. Woodward. "Three-dimensional in vitro models answer the right questions in ADPKD cystogenesis." American Journal of Physiology-Renal Physiology 315, no. 2 (August 1, 2018): F332—F335. http://dx.doi.org/10.1152/ajprenal.00126.2018.
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Novel technologies, new understanding of the basement membrane composition, and better comprehension of the embryonic development of the mammalian kidney have led to explosive growth in the use of three-dimensional in vitro models to study a range of human disease pathologies (Clevers H. Cell 165: 1586–1597, 2016; Shamir ER, Ewald AJ. Nat Rev Mol Cell Biol 15: 647–664, 2014). The development of these effective model systems represents a new tool to study the progressive cystogenesis of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is a prevalent and complex monogenetic disease, characterized by the pathological formation of fluid fill cysts in renal tissue (Grantham JJ, Mulamalla S, Swenson-Fields KI. Nat Rev Nephrol 7: 556–566, 2011; Takiar V, Caplan MJ. Biochim Biophys Acta 1812: 1337–1343, 2011). ADPKD cystogenesis is attributed to loss of function mutations in either PKD1 or PKD2, which encode for two transmembrane proteins, polycystin-1 and polycystin-2, and progresses with loss of both copies of either gene through a proposed two-hit mechanism with secondary somatic mutations (Delmas P, Padilla F, Osorio N, Coste B, Raoux M, Crest M. Biochem Biophys Res Commun 322: 1374–1383, 2004; Pei Y, Watnick T, He N, Wang K, Liang Y, Parfrey P, Germino G, St George-Hyslop P. Am Soc Nephrol 10: 1524–1529, 1999; Wu G, D’Agati V, Cai Y, Markowitz G, Park JH, Reynolds DM, Maeda Y, Le TC, Hou H Jr, Kucherlapati R, Edelmann W, Somlo S. Cell 93: 177–188, 1998). The exaggerated consequences of large fluid filled cysts result in fibrosis and nephron injury, leading initially to functional compensation but ultimately to dysfunction (Grantham JJ. Am J Kidney Dis 28: 788–803, 1996; Norman J. Biochim Biophys Acta 1812: 1327–1336, 2011; Song CJ, Zimmerman KA, Henke SJ, Yoder BK. Results Probl Cell Differ 60: 323–344, 2017). The complicated disease progression has scattered focus and resources across the spectrum of ADPKD research.
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OBERPRIELER, ROLF G., RICHARD T. THOMPSON, and MAGNUS PETERSON. "Darwin’s forgotten weevil." Zootaxa 2675, no. 1 (November 12, 2010): 33. http://dx.doi.org/10.11646/zootaxa.2675.1.3.
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G. R. Waterhouse (1839) described the first species of weevil from the specimens collected by Charles Darwin in Australia in 1836. Named Belus testaceus, it was subsequently forgotten in all literature on Australian Belidae. Study of the type, as preserved in the Natural History Museum, London, revealed its name to be a senior synonym of Belus linearis Pascoe, 1870 (syn. n.). Known from only another six specimens taken about a century ago at the same locality, King George Sound (present-day Albany) in Western Australia, plus another four of uncertain origin, this species, now in the genus Stenobelus Zimmerman, appears to be restricted to the southern tip of Western Australia but of unknown current distribution, if it is indeed still extant. The only other species of the genus, S. tibialis (Blackburn), has a wider but highly fragmented distribution across Australia, apparently being common only in the acid swamplands (wallum) of south-eastern Queensland. The larval hostplants of both species are unknown. Diagnoses are provided for the genus Stenobelus as well as for its two species, and the holotypes of all applicable names are illustrated, together with the diagnostic features of the genus. Six species recently transferred to Stenobelus from Rhinotia by Legalov (2009) are again excluded from this genus, and the name of the subgenus Germaribelus Legalov, 2009 is placed in synonymy with Rhinotia Kirby, 1819 (syn. n.).
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Tallent, Melanie K., and George R. Siggins. "Somatostatin Depresses Excitatory but not Inhibitory Neurotransmission in Rat CA1 Hippocampus." Journal of Neurophysiology 78, no. 6 (December 1, 1997): 3008–18. http://dx.doi.org/10.1152/jn.1997.78.6.3008.
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Tallent, Melanie K. and George R. Siggins. Somatostatin depresses excitatory but not inhibitory neurotransmission in rat CA1 hippocampus. J. Neurophysiol. 78: 3008–3018, 1997. In rat CA1 hippocampal pyramidal neurons (HPNs), somatostatin (SST) has inhibitory postsynaptic actions, including hyperpolarization of the membrane at rest and augmentation of the K+ M-current. However, the effects of SST on synaptic transmission in this brain region have not been well-characterized. Therefore we used intracellular voltage-clamp recordings in rat hippocampal slices to assess the effects of SST on pharmacologically isolated synaptic currents in HPNs. SST depressed both (R,S)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate and N-methyl-d-aspartate (NMDA) receptor-mediated excitatory postsynaptic currents (EPSCs) in a reversible manner, with an apparent IC50 of 22 nM and a maximal effect at 100 nM. In contrast, SST at concentrations up to 5 μM had no direct effects on either γ-aminobutyric acid-A (GABAA) or GABAB receptor–mediated inhibitory postsynaptic currents (IPSCs). The depression of EPSCs by SST was especially robust during hyperexcited states when polysynaptic EPSCs were present, suggesting that this peptide could play a compensatory role during seizurelike activity. SST effects were greatly attenuated by the alkylating agent N-ethylmaleimide, thus implicating a transduction mechanism involving the Gi/Go family of G-proteins. Use of 2 M Cs+ in the recording electrode blocked the postsynaptic modulation of K+ currents by SST, but did not alter the effects of SST on EPSCs, indicating that postsynaptic K+ currents are not involved in this action of SST. However, 2 mM external Ba2+ blocked the effect of SST on EPSCs, suggesting that presynaptic K+ channels or other presynaptic mechanisms may be involved. These findings and previous results from our laboratory show that SST has multiple inhibitory effects in hippocampus.
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Schipper, Cor A., Joost Lahr, Paul J. van den Brink, Steve G. George, Peter-Diedrich Hansen, Helena C. da Silva de Assis, Ron van der Oost, et al. "A retrospective analysis to explore the applicability of fish biomarkers and sediment bioassays along contaminated salinity transects." ICES Journal of Marine Science 66, no. 10 (August 14, 2009): 2089–105. http://dx.doi.org/10.1093/icesjms/fsp194.
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Abstract Schipper, C. A., Lahr, J., van den Brink, P. J., George, S. G., Hansen, P-D., da Silva de Assis, H. C., van der Oost, R., Thain, J. E., Livingstone, D., Mitchelmore, C., van Schooten, F-J., Ariese, F., Murk, A. J., Grinwis, G. C. M., Klamer, H., Kater, B. J., Postma, J. F., van der Werf, B., and Vethaak, A. D. 2009. A retrospective analysis to explore the applicability of fish biomarkers and sediment bioassays along contaminated salinity transects. – ICES Journal of Marine Science, 66: 2089–2105. Biological-effects monitoring in estuarine environments is complex as a result of strong gradients and fluctuations in salinity and other environmental conditions, which may influence contaminant bioavailability and the physiology and metabolism of the organisms. To select the most robust and reliable biological-effect methods for monitoring and assessment programmes, a large-scale field study was conducted in two estuarine transects in the Netherlands. The locations ranged from heavily polluted harbour areas (the ports of Rotterdam and Amsterdam) to cleaner coastal and freshwater sites. Assessment methods used included a variety of biomarkers in flounder (Platichthys flesus) and a range of in vitro (sediment extracts) and in vivo bioassays. Multivariate statistical analysis was applied to investigate correlations and relationships between various biological effects and contaminant levels in flounder liver or sediments. Several biological methods seemed to be too much affected by salinity differences for routine use in estuaries. The most discriminative biomarkers in the study were hepatic metallothionein content and biliary 1-OH pyrene in fish. Mechanism-based in vitro assays DR-CALUX and ER-CALUX applied to sediment extracts for screening of potential toxicity were much more responsive than in vivo bioassays with macro-invertebrates using survival as an endpoint.
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Schmidt, Peter J. "Judge, George G., W. E. Griffiths, R. Carter Hill, Helmut Lütkepohl, and Tsoung‐Chao Lee. The Theory and Practice of Econometrics , 2nd ed. New York: John Wiley … Sons, 1985, xxix + 1,019 pp., $@@‐@@46.95." American Journal of Agricultural Economics 67, no. 2 (May 1985): 454. http://dx.doi.org/10.2307/1240726.
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Davidson, Terence M. "Head and neck cancer, clinical decisions and management principles. Edited by Donald G. McQuarrie, George L. Adams, Alan R. Shons, Graeme A. Browne, 537 pp, year book medical publishers, Chicago, Il, 1986. $125.00." Head & Neck Surgery 10, no. 2 (November 1987): 138. http://dx.doi.org/10.1002/hed.2890100217.
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Azhar, Mukhamad, S. Suwatno, and Amir Mahmud. "DETERMINANT RETURN TO EDUCATION IN INDONESIA." Jurnal MANAJERIAL 17, no. 1 (January 26, 2018): 52. http://dx.doi.org/10.17509/manajerial.v17i1.9761.
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