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Harahap, Herpan Syafii, and Yanna Indrayana. "Obstructive Sleep Apnea Risk Level Affect Executive Function Rather than Attention." Jurnal Kesehatan Masyarakat 14, no. 2 (November 5, 2018): 272–78. http://dx.doi.org/10.15294/kemas.v14i2.14685.
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Obstructive sleep apnea (OSA) is a kind of sleep disorders which is associated with cognitive impairment, either independently or by its strong association with metabolic syndrome. OSA affected attention and executive functions. Since the diagnosis of OSA had limitation, the assessment of OSA risk level by using STOP-BANG Questionnaire instrument in common population is important. This was a cross-sectional study aimed to investigate the effect of OSA risk level determined based on STOP-BANG Questionnaire score to attention and executive functions in 82 subjects. The demographic and clinical characteristics data obtained were age, gender, level of education, hypertension, body mass index (BMI), neck circumference, OSA risk level, and attention and executive functions. Attention function was assessed by using Forward Digit Span and Trailmaking Test A (TMT-A) instruments, while executive function was assessed by using Backward Digit Span and Verbal Fluency Test instruments. The demographic and clinical characteristics data showed significant higher proportion of male gender, large neck circumference, and hypertension in high risk OSA group. The OSA risk level significantly impaired the executive function but did not impaired attention function.
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Chevignard, Mathilde P., Cathy Catroppa, Jane Galvin, and Vicki Anderson. "Development and Evaluation of an Ecological Task to Assess Executive Functioning Post Childhood TBI: The Children's Cooking Task." Brain Impairment 11, no. 2 (September 1, 2010): 125–43. http://dx.doi.org/10.1375/brim.11.2.125.
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AbstractPurpose:Traumatic brain injury (TBI) often leads to executive functions deficits, which may be responsible for severe and longstanding disabilities in everyday activities. Sensitivity and ecological validity of neuropsychological tests of executive functions have been questioned. The aims of this study were to pilot an ecological open-ended assessment of executive functions in children, the ‘Children's Cooking Task’ (CCT), specifically to report its reliability, discriminant validity and concurrent validity.Methods:Twenty-five children with mild (n= 10) or moderate-to-severe TBI (n= 15), and 21 matched controls (aged 8 to 20 years) participated in the study. An open-ended cooking task was designed to test multi-tasking abilities. It required the preparation of two simple recipes using specific instructions. Outcome measures included the number of errors and an overall qualitative analysis of the task. Validating measures of executive functions included the Delis Kaplan Executive Function System, the Six-Part Test and two questionnaires completed by the child's primary care-giver: the Behavior Rating Inventory of Executive Function and the Dysexecutive Questionnaire for Children.Results:Internal consistency of the Children's Cooking Task was high (Cronbach's alpha = .86), as was test–retest reliability (ICC = .89). Children with moderate-to-severe TBI, as well as children with mild TBI made significantly more errors in the Children's Cooking Task in comparison to controls (p< .001). The CCT was correlated with several tests and one questionnaire of executive functioning (Trails, verbal fluency, sorting, 20 questions, Dysexecutive Questionnaire).Discussion and Conclusion:The Children's Cooking Task has good interrater and test–retest reliability, as well as good discriminant and concurrent validity.
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Barrios-Fernandez, Sabina, Margarita Gozalo, Maria Amado-Fuentes, Jorge Carlos-Vivas, and Andres Garcia-Gomez. "A Short Version of the EFECO Online Questionnaire for the Assessment of Executive Functions in School-Age Children." Children 8, no. 9 (September 11, 2021): 799. http://dx.doi.org/10.3390/children8090799.
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Executive function (EF) is a group of processes that allow individuals to be goal-oriented and to have adaptive functioning, so that adequate performance is essential for success in activities of daily living, at school and in other activities. The present study aims to create a short version of the Executive Functioning Questionnaire (EFECO) since there is a gap in the Spanish literature due to the lack of behavioural observation questionnaires at school age. A total of 3926 participants completed the online questionnaire. Subsequently, the validity and reliability of the data are analysed. The results show that the short version of the questionnaire, the EFECO-S, has a structure with five dimensions (emotional self-control, initiation, working memory, inhibition, and spatial organisation), as well as a second-order factor (global executive skill) and high reliability (ordinal Alpha = 0.68–0.88). The EFECO is composed of 67 items, while the EFECO-S has 20 items, four per factor, which turns it into a quick and easy to apply test. Therefore, it becomes an interesting alternative to be applied in screening processes with children who may be experiencing executive difficulties.
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Escolano-Pérez, Elena, Rita Pilar Romero-Galisteo, Jairo Rodríguez-Medina, and Pablo Gálvez-Ruiz. "Executive function assessment: Adaptation of the Amsterdam executive function inventory using Spanish first-year university students from two knowledge areas." PLOS ONE 17, no. 8 (August 19, 2022): e0272802. http://dx.doi.org/10.1371/journal.pone.0272802.
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Objective Many university students have difficulties in adapting to autonomous learning due to executive functioning deficits. In the Spanish university context, there is a lack of reliable validated instruments for the evaluation of executive functioning. In this sense, the aim of this research is to present the process of adaptation and validation of the Amsterdam Executive Function Inventory (AEFI) for the evaluation of executive functioning in the Spanish context. Methods This study integrates two sequential processes: questionnaire translation and back-translation, and evaluation of the psychometric properties (exploratory and confirmatory factor analysis were conducted), reliability, validity and multigroup analysis to identify factorial invariance. An online questionnaire was used for data collection and R package lavaan software was administered to a sample of 519 first-year university students (270 females and 249 males). Results The exploratory factor analysis evidenced an interna structure of three factors with adequate internal consistency (Cronbach’s alpha higher than 0.70), endorsed in the confirmatory factor analysis that indicated an adequate goodness-of-fit-indexes for the model. The composite reliability showed values between 0.74 and 0.82, and the convergent (average variance extracted values ranged from 0.50 to 0.61) and discriminant validity were adequate. A multigroup-analysis showed the invariance factorial through the difference in the RMSEA, CFI and TLI index, performed both in the model comparison according to gender and academic disciplines. Conclusion The AEFI adapted for Spanish has practical implications for the management of university students, as it can facilitate the improvement of university policies designed to foster the development of executive functions, specifically in first-year students.
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Bulzacka, Ewa, Jeanne Vilain, Franck Schürhoff, Alexandre Méary, Marion Leboyer, and Andrei Szöke. "A self administered executive functions ecological questionnaire (the Behavior Rating Inventory of Executive Function - Adult Version) shows impaired scores in a sample of patients with schizophrenia." Mental Illness 5, no. 1 (September 16, 2013): 4. http://dx.doi.org/10.4081/mi.2013.e4.
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Subjective measurements of cognition have seldom been used in schizophrenia. This is mainly due to the assumption that such measurements lack sensitivity in a disorder characterized by poor insight. We investigated the capacity of BRIEF-A (Behavior Rating Inventory of Executive Function - Adult Version: a self-administered, ecological questionnaire) to identify executive deficits in adults with schizophrenia. The global score and each domain-specific score was significantly lower in patients than in healthy controls. BRIEF-A could be a useful complement to objective measurements, providing a subjective assessment of everyday consequences of executive dysfunction in patients with schizophrenia.
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Bulzacka, Ewa, Jeanne Vilain, Franck Schürhoff, Alexandre Méary, Marion Leboyer, and Andrei Szöke. "A self administered executive functions ecological questionnaire (the Behavior Rating Inventory of Executive Function - Adult Version) shows impaired scores in a sample of patients with schizophrenia." Mental Illness 5, no. 1 (February 11, 2013): 14–16. http://dx.doi.org/10.1108/mi.2013.e4.
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Subjective measurements of cognition have seldom been used in schizophrenia. This is mainly due to the assumption that such measurements lack sensitivity in a disorder characterized by poor insight. We investigated the capacity of BRIEF-A (Behavior Rating Inventory of Executive Function - Adult Version: a self-administered, ecological questionnaire) to identify executive deficits in adults with schizophrenia. The global score and each domain-specific score was significantly lower in patients than in healthy controls. BRIEF-A could be a useful complement to objective measurements, providing a subjective assessment of everyday consequences of executive dysfunction in patients with schizophrenia.
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MCAULEY, TARA, SHIRLEY CHEN, LISA GOOS, RUSSELL SCHACHAR, and JENNIFER CROSBIE. "Is the behavior rating inventory of executive function more strongly associated with measures of impairment or executive function?" Journal of the International Neuropsychological Society 16, no. 3 (March 1, 2010): 495–505. http://dx.doi.org/10.1017/s1355617710000093.
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AbstractThe Behavior Rating Inventory of Executive Function (BRIEF) is commonly used in the assessment of children and adolescents presenting with a wide range of concerns. It is unclear, however, whether the questionnaire is more closely related to general measures of behavioral disruption and impairment or to specific measures of executive function. In the present study, associations between the Behavioral Regulation Index and Metacognition Index of the BRIEF and cognitive, behavioral, and academic measures were examined in a sample of clinic-referred youth (n = 60) and healthy youth (n = 37) 6–15 years of age. Measures included ratings of inattentive and hyperactive-impulsive symptoms in youth, ratings of how well youth functioned in their everyday environments, youth’s scores on measures of reading and math, and youth’s scores on measures of inhibition, performance monitoring, and working memory. Although both BRIEF indices were strongly related to parent and teacher ratings of behavioral disruption and impairment, neither was associated with youth’s scores on the performance-based tasks of executive function. These findings support the use of the BRIEF as a clinical tool for assessing a broad range of concerns, but raise questions about the relation of the BRIEF to performance-based tasks that are commonly used to assess executive function. (JINS, 2010, 16, 495–505.)
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Preston, Jenny, Richard Hammersley, and Helen Gallagher. "The Executive Dysfunctions Most Commonly Associated with Multiple Sclerosis and Their Impact on Occupational Performance." British Journal of Occupational Therapy 76, no. 5 (May 2013): 225–33. http://dx.doi.org/10.4276/030802213x13679275042726.
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Introduction: The relationship between executive dysfunction and functional status in people with multiple sclerosis (MS) is not fully understood. This study attempts to provide empirical evidence of the executive dysfunctions most commonly associated with MS and to develop an understanding of the impact of this on occupational performance. Method: This cross-sectional study explores the relationships between an MS group (n = 69) and a healthy control group (n = 30) using the Behavioural Assessment of Dysexecutive Syndrome and the Dysexecutive Questionnaire. Results: More than a third of people with MS experienced some impairment of executive function sufficient to interfere with occupational performance. The most commonly occurring problems included planning, problem solving, behavioural regulation, lack of insight, apathy and lack of motivation. Executive function deficits were evident from the early stages of the disease, although participants with a secondary progressive form of MS appeared to demonstrate greater difficulties. Conclusion: While the Behavioural Assessment of Dysexecutive Syndrome may reliably identify the presence of executive dysfunction within this clinical population it does not inform clinicians of the impact on occupational performance. Self-reported executive function demonstrates heightened awareness of occupational performance deficits and may lead to more accurate reporting of executive dysfunction. The impact of depression, fatigue and anxiety, however, requires further investigation.
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Czermainski, Fernanda Rasch, Felipe Ornell, Luciano Santos Pinto Guimarães, Félix Kessler, Lísia Von Diemen, and Rosa Maria Martins De Almeida. "Assessment of executive functions and inhibitory control in alcohol and crack use disorders." Psico 49, no. 1 (April 4, 2018): 21. http://dx.doi.org/10.15448/1980-8623.2018.1.25877.
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This study assessed executive functions and inhibitory control in alcohol and crack users, as previous research suggests an association between substance-related disorders and impaired self-regulation and impulse control. In this study, 67 men aged 18-65 years completed the following instruments: sociodemographic questionnaire, Vocabulary and Matrix Reasoning (Wechsler Abbreviated Scale of Intelligence), Five Digit Test, and Behavioral Assessment of the Dysexecutive Syndrome. Alcohol and crack users showed deficits involving processing speed, response inhibition, flexibility, abstraction, planning, and monitoring. Analysis per type of drug revealed poorer cognitive performance among alcohol users. Years of drug use were associated with planning deficits. These findings are consistent with the hypothesis of an association between drug abuse and cognitive changes. In conclusion, impairments in executive functioning and inhibitory control were found in the study samples.***Avaliação das funções executivas e controle inibitório nos transtornos por uso de álcool e crack***Este estudo investigou as funções executivas e o controle inibitório em usuários de álcool e crack, pois pesquisas prévias sugerem associação entre os transtornos relacionados a substâncias e o comprometimento das capacidades de autorregulação e de controle dos impulsos. Neste estudo, 67 homens com idades entre 18-65 anos responderam aos seguintes instrumentos: questionário sociodemográfico, Vocabulário e Raciocínio Matricial (Wechsler Abbreviated Scale of Intelligence), Five Digit Test e Behavioural Assessment of the Dysexecutive Syndrome. Os usuários de álcool e crack apresentaram déficits envolvendo velocidade de processamento, inibição de respostas, flexibilidade, abstração, planejamento e monitoramento. A análise por droga de abuso revelou desempenho cognitivo inferior entre os alcoolistas. O tempo de abuso de drogas foi associado a déficits de planejamento. Esses achados são consistentes com a hipótese de associação do abuso de drogas com alterações cognitivas. Em conclusão, foram observadas alterações do funcionamento executivo e do controle inibitório nas amostras de usuários avaliadas.
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Alateeq, Halah, and Tamiko Azuma. "Words Versus Pictures: Bilingual Performance on Verbal and Pictorial Measures of Executive Functions." Journal of Speech, Language, and Hearing Research 65, no. 3 (March 8, 2022): 1087–103. http://dx.doi.org/10.1044/2021_jslhr-21-00317.
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Purpose: This study examined bilinguals' performance on functional executive function map tasks such as the Zoo Map from the Behavioural Assessment of the Dysexecutive Syndrome and the extent to which working memory, set-shifting, and inhibition measures predicted bilinguals' performance on these tasks. Additionally, we explored the utility of pictorial map tasks as a measure of complex executive function in bilinguals. We hypothesized that bilinguals would perform better on the pictorial map tasks due to the reduced language processing demand. Method: The analyses included 131 bilingual young adults who completed a comprehensive language history questionnaire, an English proficiency test, a battery of working memory and executive function tasks, and verbal and pictorial map tasks. Results: Contrary to predictions, bilinguals' performance on the verbal maps did not differ significantly from that on the pictorial maps. Two multiple regression models significantly predicted performance on the verbal and pictorial maps, accounting for 7%–25% of the variance in the map scores. Working memory and interference control were the most prominent predictors within these models. Conclusions: In our study, bilinguals' performance on the verbal maps did not differ significantly from that on the pictorial maps. Additionally, English proficiency did not correlate with the participants' verbal map scores. These results suggest that executive function map tasks (e.g., the Zoo Map) are a useful clinical tool for assessing executive function in bilinguals. The findings of this study are discussed in light of the current literature on executive functions in bilinguals.
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Qin, Tong, and Chunfu Chen. "Cognitive Dysfunction in Migraineurs." Medicina 58, no. 7 (June 29, 2022): 870. http://dx.doi.org/10.3390/medicina58070870.
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Background and Objectives: Migraines are one of the most common types of primary headaches in neurology. Many studies to date have investigated cognitive impairment in migraineurs, but the results are inconsistent. This study aimed to investigate the cognitive function of migraineurs and explore the influencing factors. Material and Methods: A total of 117 patients with primary headaches (87 with migraine and 30 with tension-type headache (TTH)) and 30 healthy controls were enrolled. General information and data on headache clinical characteristics, and assessments of headache-related disability, psychological symptoms, and cognitive function were collected for statistical analysis. Results: The Montreal Cognitive Assessment (MoCA) total score and the scores of visuospatial and executive functions, language, and delayed recall in the migraine and TTH groups were significantly lower than those in the healthy control group (all p < 0.05). The MoCA total score did not correlate with Headache impact test-6, Migraine Disability Assessment Questionnaire, Patient Health Questionnaire-9, or Generalized Anxiety Disorder Questionnaire-7 scores in migraineurs (all p > 0.0125). The multiple linear regression analysis showed that age and duration of attack had a major influence on the overall and various fields of cognition in migraineurs. Conclusion: The study confirmed the impairment of cognitive function in patients with migraine and TTH, and found that the duration of attack had an effect on cognitive function in migraineurs.
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Kato, Miho, Daisuke Yoneoka, Kevin Urayama, Chikako Kiyotani, Kimikazu Matsumoto, and Satomi Sato. "Development and validation of the Childhood Cancer Survivor Study-Neurocognitive Questionnaire (CCSS-NCQ) Japanese version." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e22025-e22025. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e22025.
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e22025 Background: The lives of childhood cancer survivors (CCS) may be impacted by symptoms of neurocognitive dysfunction. Decline in executive function, one component of the construct concept of neurocognitive function, may affect the ability to be independent in later life; thus,ssessment and intervention are important. In the United States, the Childhood Cancer Survivor Study-Neurocognitive Questionnaire (CCSS-NCQ) developed by St. Jude Children’s Research Hospital has been widely utilized in clinical practice. It is a self-administered scale for screening daily difficulties regarding organization, emotional regulation, memory, and task efficiency which all fall under the concept of the executive function. To expand the tools for executive function assessment in Japan, we developed the CCSS-NCQ Japanese version and performed a validation study among the adolescent and young adult (AYA)-CCS population. Methods: The Japanese version of the CCSS-NCQ was developed by conducting linguistic validation. Japanese AYA-CCS of all cancer types were recruited and asked to complete this 32-question self-administered questionnaire. Exploratory and confirmatory factor analysis (FA) with the Promax rotation were conducted. Results: In total, 106 participants responded. The mean age of participants was 20.6 ± 5.3 years, and 49.1% were male. The mean age at diagnosis was 8.7 ± 4.8 years; 46.2% of participants were diagnosed with brain tumors, 37.7% with hematological malignancy, and 12.3% with solid tumors. The FA identified the similar four-factor structure of organization, emotional regulation, memory, and task efficiency as the original CCSS-NCQ with factor loading set at 0.4. The Cronbach’s alpha was 0.84 - 0.92. Conclusions: Neurocognitive dysfunction could be a crucial late complication of childhood cancer, and maintaining executive function, in particular, is essential for sustaining the quality of life among CCS. The CCSS-NCQ Japanese version is the first internationally translated CCSS-NCQ. The successful validation in the Japanese population will expand opportunities for future international collaboration to identify race/ethnicity-based disparities, as well as scale enhancement for application to CCS worldwide.
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Ruffini, Costanza, Gian Marco Marzocchi, and Chiara Pecini. "Preschool Executive Functioning and Child Behavior: Association with Learning Prerequisites?" Children 8, no. 11 (October 26, 2021): 964. http://dx.doi.org/10.3390/children8110964.
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Preschool age is a golden period for the emergence of executive functions (EFs) that, in turn, predict learning and adaptive behavior throughout all life. The study was aimed to identify which EFs measures significantly explained the learning prerequisites and the mediation role of self-regulatory and executive behavior recorded in structured or free settings. One hundred and twenty-seven preschoolers were remotely assessed by standardized tests of response inhibition, working memory, control of interference, and cognitive flexibility. Teachers provided a global measure of learning prerequisites by an observational questionnaire. Self-regulatory behavior during the assessment was evaluated by a rating scale filled by the examiners. Executive function behavior in daily life was measured by a questionnaire filled by parents. Accuracy in tasks of response inhibition and working memory explained about 48% of the variability in learning prerequisites while response speed and accuracy in the control of interference and in cognitive flexibility were not significant. EFs also had indirect effects, mediated by the child’s self-regulatory behavior evaluated during the assessment but not in daily life. The results are interpreted with respect to the contribution of the main EF components to school readiness and the mediation of the child behavior as measured in structure contexts.
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Canali, Fabíola, Sonia M. D. Brucki, Paulo H. F. Bertolucci, and Orlando F. A. Bueno. "Reliability study of the Behavioral Assessment of the Dysexecutive Syndrome adapted for a Brazilian sample of older-adult controls and probable early Alzheimer's disease patients." Revista Brasileira de Psiquiatria 33, no. 4 (May 13, 2011): 338–46. http://dx.doi.org/10.1590/s1516-44462011005000015.
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OBJECTIVE: Ecological tests are useful in assessing executive function deficits and may be of value in appraising response to treatment in Alzheimer's disease patients. Our aims were to examine executive function using the Behavioral Assessment of the Dysexecutive Syndrome for a Brazilian sample of older-adult controls and probable early Alzheimer's disease patients, and verify the applicability of this test battery. METHOD: Forty-one older-adult controls were matched with mild Alzheimer's disease patients by age, education, and gender. RESULTS: There significant inter-group differences in overall profile and almost all subtests except temporal judgment, time spent on planning the first and second Zoo Map visit, number of errors when copying drawings, naming pictures and Six Modified Elements arithmetic, and dysexecutive questionnaire self-rating. The Behavioral Assessment of the Dysexecutive Syndrome item that best discriminated controls from patients was the Modified Six Elements - adapted (general index), with a sensitivity of 80% and specificity of 90%, (AUC = 0.91, p < 0.001). CONCLUSION: Behavioral Assessment of the Dysexecutive Syndrome was effective in detecting executive function deficits in mild Alzheimer's disease patients, particularly the task switching, time monitoring, and rule-shift subtests.
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Vybhavi, Jyothi. "Effect of haemoglobin deficiency on cognitive functions in elderly of Bangalore city." Indian Journal of Clinical Anatomy and Physiology 8, no. 2 (July 15, 2021): 135–39. http://dx.doi.org/10.18231/j.ijcap.2021.031.
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Adequate nutrition is fundamental to healthy ageing. Among older adults with anaemia, approximately one-third have evidence of iron, folate, and/or vitamin B deficiency. Lower haemoglobin levels are common in older adults and frequently are measured in clinical practice.1. To assess haemoglobin levels in elderly. 2. To assess cognitive functions in different levels of haemoglobin. This study involved 80 healthy elderly subjects with consideration of inclusion and exclusion criteria. Written informed consent was taken. For each subject, blood sample of 4ml was collected for Haemoglobin assessment. Anthropometric measurements were taken. 24-hour dietary recall, General history questionnaire and Spreen & Stauss Neuropsychology battery of tests were administered.Results were compiled and statistically analyzed. The results show that Elderly with haemoglobin deficiency had statistically significant low scores in all parameters (P < 0.05), especially with executive function & processing speed.It can be concluded that haemoglobin levels were associated with worse global cognitive function and greater decline in psychomotor speed and executive function.
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Sangawi, Hoshiar, John Adams, and Nadja Reissland. "Individual Differences in Executive Function: The Role of Parental Monitoring as a Moderator." Journal of Attention Disorders 25, no. 3 (September 21, 2018): 364–76. http://dx.doi.org/10.1177/1087054718797420.
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Objective: Parental monitoring is a factor which affects verbal and nonverbal inhibition components of children’s executive functions.,. Method: 112 sixth-grade Kurdish children (mean age: 11 years 5 months) participated in the study. Children were matched on level of hyperactivity. Parents completed the Parental Monitoring Assessment (PMA) and the Strengths and Difficulties Questionnaire (SDQ). Children completed theStop-Signal task, Modified Opposite Worlds and a challenging star puzzle in order to assess executive function components. PROCESS analysis was also used to perform the moderation analysis. Results: Children characterized by poor parental monitoring had deficits in inhibitory control and had significantly slower processing speeds and made significantly more errors than their matched controls. Furthermore, children with high levels of hyperactivity had difficulties in inhibitory control, accuracy, processing speed, and task persistence compared with the control group.Contrary to our prediction, there were no significant differences in reaction times compared with the control group. PROCESS analysis showed a significant moderating role of parental monitoring in the association between each of accuracy, verbal inhibition, and task persistence with hyperactivity. Conclusion: the current study suggests that, similar to hyperactivity, children with poor parental monitoring appear to have difficulties in executive function.
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Almeida, Bruna de Assis, and Amer Cavalheiro Hamdan. "Impulsiveness and executive functions in Parkinson’s disease." Dementia & Neuropsychologia 13, no. 4 (December 2019): 410–14. http://dx.doi.org/10.1590/1980-57642018dn13-040007.
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ABSTRACT Cognitive functions, such as impulsiveness and executive functions, are often impaired in Parkinson’s disease. Objective: to analyze the relationship between impulsiveness and executive functions (EF) in people with Parkinson’s disease (PD). Methods: a correlation study involving a sample of 50 patients with an established diagnosis of PD aged 40 years or older was conducted using the following instruments: Demographic Questionnaire, Montreal Cognitive Assessment Basic (MOCA-B), Barratt’s Impulsiveness Scale (BIS-11) and Frontal Assessment Battery (FAB). Results: Pearson’s correlation analysis indicated low associations (p<0.05) between the MOCA-B and BIS-11, with a value of -0.11, and between the FAB and BIS-11, with a value of -0.16. A significant correlation between the MOCA-B and FAB was found, with a value of 0.73. Conclusion: this study revealed an association between EF and other cognitive functions, but no association between impulsivity and EF in Parkinson’s disease.
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Podobnik Uršič, Simona, and Karmen Pižorn. "Identifying the Executive Function Strategies in Learning Tenses and in the Verb Gap-Fill Task Performance of an EFL Student with Dyslexia." ELOPE: English Language Overseas Perspectives and Enquiries 18, no. 2 (December 29, 2021): 205–24. http://dx.doi.org/10.4312/elope.18.2.205-224.
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Teaching of executive function strategies in learning and task performance to EFL students with specific learning difficulties plays an important role in inclusive education. The present case study presents an investigation of the strategies supporting executive functioning in the frames of learning self-regulation, which are applied in learning tenses and the verb gap-fill task performance of a grammar school student with dyslexia. A triangulation research approach included a semi-structured interview with the participant, a qualitative assessment of her written work, a questionnaire with the parents and EFL teacher, and a study of the evaluation report. The results highlight the participant’s difficulties in tense acquisition and frequent task performance errors, weak tense knowledge and low application of strategies supporting executive functioning. The results might help teachers create an inclusive environment in EFL classes.
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Bünger, Anette, Natalie Urfer-Maurer, and Alexander Grob. "Multimethod Assessment of Attention, Executive Functions, and Motor Skills in Children With and Without ADHD: Children’s Performance and Parents’ Perceptions." Journal of Attention Disorders 25, no. 4 (January 30, 2019): 596–606. http://dx.doi.org/10.1177/1087054718824985.
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Objective: We examined whether children with attention-deficit/hyperactivity disorder (ADHD) differ from children without ADHD in attention, executive functions, and motor skills and whether measures of parents’ perceptions and children’s performance reveal comparable results. Method: About 52 children with ADHD and 52 children without ADHD aged 6 to 13 years completed performance-based measures of attention, executive functions, and motor skills. Parents completed questionnaires to rate their children’s skills. Results: Parent questionnaires but not performance-based measures revealed higher inattention and lower executive function skills in children with ADHD compared to controls. For motor skills, both measurement methods revealed lower mean values and a higher number of children showing an impairment in the ADHD group. Parent-reported difficulties but not performance-based measures were related to the presence of an ADHD diagnosis. Conclusion: Our findings suggest that considering both parent questionnaires and performance-based measures will lead to a comprehensive picture of a child’s strengths and difficulties.
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Ratiu, Ileana, and Tamiko Azuma. "Assessment of executive function in bilingual adults with history of mild traumatic brain injury." Brain Impairment 21, no. 1 (July 30, 2019): 32–46. http://dx.doi.org/10.1017/brimp.2019.17.
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AbstractBackground and objective:Adults with a history of traumatic brain injury (TBI) often show deficits in executive function (EF), including the ability to inhibit, switch, and attend to task relevant information. Although performances differences between bilinguals and monolinguals have been observed in EF tasks, there is little research on the effect of TBI on EF in bilinguals. In this study, an ecologically valid standardized measure and experimental computerized tasks of EF were administered to Spanish-English bilingual adults with and without history of mild traumatic brain injury (mTBI).Method:Twenty-two bilinguals with a history of mTBI [mean age=20.1 years, SD=3.7; education=13.4 years, SD=0.7] and 20 control bilinguals [mean age=20.8 years, SD=3.6; education=13.7 years, SD=1.1], matched for age and education, completed language proficiency questionnaires, the Functional Assessment of Verbal Reasoning and Executive Strategies (FAVRES), English and Spanish language assessments, and a Flanker task (a test of inhibition).Results:Performance was analyzed using analyses of covariance. The results revealed that bilinguals with a history of mTBI performed worse on both the standardized assessment (FAVRES) and inhibition task. Interestingly, self-reported EF deficits were consistent with performance on these measures.Conclusion:The findings of this study provide useful information regarding assessment of EF deficits in bilinguals with a history mTBI. Computerized experimental tasks of EF may also prove useful in the assessment of EF in individuals with mTBI.
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Gerçek, Muhammed, Anca A. Irimie, Mustafa Gerçek, Henrik Fox, Vera Fortmeier, Tanja K. Rudolph, Volker Rudolph, and Kai P. Friedrichs. "Dynamics of Cognitive Function in Patients with Heart Failure Following Transcatheter Mitral Valve Repair." Journal of Clinical Medicine 11, no. 14 (July 9, 2022): 3990. http://dx.doi.org/10.3390/jcm11143990.
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Aims: Interventional transcatheter edge-to-edge mitral valve repair (TMVR) is an established treatment option for patients with severe mitral regurgitation (MR) and high operative risk. Cognitive impairment is one of the most common conditions among often extensive comorbidities in these patients. The specific patterns of cognitive decline and particularly the effect of TMVR are not well described. Thus, this study aimed to investigate into the impact of TMVR on cognitive impairment, exercise capacity, and quality of life. Methods: Cognitive function (executive, naming, memory, attention, language, abstraction, and orientation) was assessed with the standardized Montreal Cognitive Assessment test (MoCA; range between 0 and 30 points) before and 3 months after TMVR in 72 consecutive patients alongside echocardiographic examination and assessment of exercise capacity (six-minute walk test) as well as quality-of-life questionnaires (Minnesota living with heart failure questionnaire, MLHF-Q). Results: Patients’ median age was 81 [76.0; 84.5] years, 39.7% were female with a median EuroScore II of 4.4% [2.9; 7.7]. The assessment of cognitive function showed a significant improvement of the cumulative MoCA-Test result (from 22.0 [19.0; 24.5] to 24 [22.0; 26.0]; p < 0.001) with significant changes in the subcategories executive (p < 0.001), attention (p < 0.001), abstraction (p < 0.001), and memory (p < 0.001). In addition, quality of life (from 47.5 [25.0; 69.3] to 24.0 [12.0; 40.0]; p < 0.001) and exercise capacity (from 220.0 m [160.0; 320.0] to 280.0 m [200.0; 380.0]; p = 0.003) increased significantly 3 months after the TMVR procedure. Conclusions: TMVR leads to a significant improvement of cognitive function, exercise capacity, and quality of life in patients with chronic heart failure in 3 months follow up and again highlights the benefit of the evermore established TMVR procedure for patients with high operative risk.
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Galindo, G., J. Galarza, L. García, A. Padilla, A. Negrete, and R. López. "Normative Data for Executive Function and Emotion Interaction Assessment in Adolescents from Rural Areas." Archives of Clinical Neuropsychology 34, no. 7 (August 30, 2019): 1252. http://dx.doi.org/10.1093/arclin/acz029.19.
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Abstract Objective The present work is part of the ongoing project of examining the validation and standardization of the Executive Functions and Emotion Assessment for Adolescents with Risk Behaviors (EFEAA) test in the rural areas of Northwest Mexico. The objectives of the present study were (1) to examine the effects of age and risk behavior on emotionally interfered working memory ability, measured as performance on the Emotionally Interfered Working Memory Task (EIWMT) section of the EFEAA in a group of healthy adolescents from rural areas; and (2) to use these results to construct normative data that can be used in clinical practice. Participants and Method A total of 275 adolescents, 14.1 years old, geographically distributed among northwest Mexico were included in the sample. They were individually assessed using the Montreal Cognitive Assessment, Risk Behavior Questionnaire, including: sexual risk behavior, impulsiveness, drug, alcohol, and tobacco consumption, unhealthy food intake, and physical inactivity; for measuring emotion-cognition interaction we used the EIWMT. Results Results of this study present a database supported by factors of risk behavior and working memory, which includes: predictors for conduct disorders, drug use, and delinquency, in addition to correlations between the performance of emotionally interfered working memory and risk behaviors associated to health. Percentile and normal distribution tables were generated, demonstrating that there is a high prevalence of risk behavior in rural areas. Conclusions This study demonstrates data related to rural areas in northwest Mexico, a region where adolescents are frequently involved in risk behaviors. Additionally, protective factors are understudied in Mexico-US border cities. Further analyses are needed to find reward delay skills on the studied sample as well as urban area comparisons.
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Proust, François, Olivier Martinaud, Emmanuel Gérardin, Stéphane Derrey, Sophie Levèque, Sandrine Bioux, Eléonore Tollard, et al. "Quality of life and brain damage after microsurgical clip occlusion or endovascular coil embolization for ruptured anterior communicating artery aneurysms: neuropsychological assessment." Journal of Neurosurgery 110, no. 1 (January 2009): 19–29. http://dx.doi.org/10.3171/2008.3.17432.
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Object For anterior communicating artery (ACoA) aneurysms, endovascular coil embolization constitutes a safe alternative therapeutic procedure to microsurgical clip occlusion. The authors' aim in this study was to evaluate the quality of life (QOL), cognitive function, and brain structure damage after the treatment of ruptured ACoA aneurysms in a group of patients who underwent microsurgical clipping (36 patients) compared with a reference group who underwent endovascular coiling (14 patients). Methods At 14 months posttreatment all patients underwent evaluations by independent observers. These observers evaluated global efficacy, executive functions using a frontal assessment battery of tests (Trail making test, Stroop tasks, dual task of Baddeley, verbal fluency, and Wisconsin Card Sorting test), behavior dysexecutive syndrome (the Inventaire du Syndrome Dysexécutif Comportemental questionnaire [ISDC]), and QOL by using the Reintegration To Normal Living Index. Brain damage was analyzed using MR imaging. Results In the microsurgical clipping and endovascular coiling groups, the distribution on the modified Rankin Scale (p = 0.19) and mean QOL score (85.4 vs 83.4, respectively) were similar. Moreover, the proportion of executive dysfunctions (19.4 vs 28.6%, respectively) and the mean score on the ISDC questionnaire (8.9 vs 8.5, respectively) were not significant, but verbal memory was more altered in the microsurgical clipping group (p = 0.055). Magnetic resonance imaging revealed that the incidence of local encephalomalacia and the median number of lesions per patient increased significantly in the microsurgical clipping group (p = 0.003). Conclusions In the 2 groups, no significant difference was observed regarding QOL, executive functions, and behavior. Despite the significant decrease in verbal memory after microsurgical clipping, the interdisciplinary approach remains a safe and useful strategy.
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Cho, Inkyoung, SangYun Kim, Jeong Gue Choi, and Joon-Ho Shin. "Subjective Memory Complaints and Sensitivity of the Subjective Memory Complaint Questionnaire in Post-Stroke Dementia Patients." Dementia and Geriatric Cognitive Disorders 49, no. 3 (2020): 279–85. http://dx.doi.org/10.1159/000509083.
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<b><i>Introduction:</i></b> Subjective memory complaints (SMCs) among stroke patients are common. To date, reports on SMCs using the Subjective Memory Complaint Questionnaire (SMCQ) are limited. We provided descriptive information on SMCs using the SMCQ alongside objective neuropsychological function assessment in stroke patients and established the sensitivity of SMCQ for post-stroke dementia. <b><i>Methods:</i></b> In total, 419 consecutive stroke patients who were admitted to a stroke unit for younger populations (age <65 years) at a rehabilitation hospital from June 1, 2014, to January 1, 2020, were reviewed. SMCs were measured using the SMCQ. Objective neuropsychological function was assessed using protocols of the Vascular Cognitive Impairment Harmonization Standards. <b><i>Results:</i></b> SMCs were significantly correlated with objective neuropsychological functions including memory, executive function, language, and depression. SMCs were not significantly correlated with visuospatial function. The SMCQ exhibited comparable sensitivity to that of Mini-Mental Status Examination for evaluating post-stroke dementia. <b><i>Conclusions:</i></b> The SMCQ may be a valid measure of cognitive function among patients with stroke, is sensitive for post-stroke dementia, and may assume a complementary role for assessing patients with stroke.
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Kringle, Emily A., Lauren Terhorst, Meryl A. Butters, and Elizabeth R. Skidmore. "Clinical Predictors of Engagement in Inpatient Rehabilitation Among Stroke Survivors With Cognitive Deficits: An Exploratory Study." Journal of the International Neuropsychological Society 24, no. 6 (March 19, 2018): 572–83. http://dx.doi.org/10.1017/s1355617718000085.
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AbstractObjectives: The purpose of this exploratory study was to identify clinical predictors that could distinguish clients’ level of engagement in inpatient rehabilitation following stroke. Methods: This is a secondary analysis of pooled data from three randomized controlled trials that examined the effects of a behavioral intervention. The sample (n=208) consisted of clients with stroke who had cognitive deficits (Quick-EXIT≥3) and were admitted to inpatient rehabilitation facilities associated with a university medical center. Individuals with pre-morbid dementia, aphasia and mood disorders were excluded. The Pittsburgh Rehabilitation Participation Scale was used to measure engagement. Clinical predictors were measured using the Functional Independence Measure, National Institutes of Health Stroke Scale, Repeatable Battery for the Assessment of Neuropsychological Status, selected subtests of the Delis-Kaplan Executive Function System, Patient Health Questionnaire-9, and Chedoke McMaster Stroke Assessment. Simple logistic regression identified individual clinical predictors associated with engagement. Hierarchical logistic regression identified the strongest predictors of engagement. Results: Impairments in executive functions [mean D-KEFS, odds ratio (OR)=4.062; 95% confidence interval (CI)=.866, 19.051], impairments in visuospatial skills (RBANS Visuospatial Index Score, OR=3.940; 95% CI=1.317, 11.785), impairments in mood (Patient Health Questionnaire-9, OR=2.059, 95% CI=.953, 4.449), and male gender (OR=2.474; 95% CI=1.145, 5.374) predicted levels of engagement in inpatient rehabilitation after controlling for study intervention group, baseline stroke severity, and baseline disability. Conclusions: Executive functions, visuospatial skills, mood, and gender distinguished individuals with high or low engagement in inpatient rehabilitation following stroke. Further studies should examine additional factors that may influence engagement (therapist-client relationship, treatment expectancy). (JINS, 2018, 24, 572–583)
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Canali, Fabiola, Sonia Maria Dozzi Brucki, and Orlando Francisco Amodeo Bueno. "Behavioural assessment of the dysexecutive syndrome (BADS) in healthy elders and Alzheimer´s disease patients: preliminary study." Dementia & Neuropsychologia 1, no. 2 (June 2007): 154–60. http://dx.doi.org/10.1590/s1980-57642008dn10200007.
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Abstract Although the main initial deficit is considered to be in the memory domain, an early impairment of executive functions is also found in AD where these deficits are correlated to functional impairment. Ecological tests are more indicated to evaluate executive impairment, and are better able to assist in treating AD patients than more commonly used tests. Objectives: The aim of this preliminary study is to verify the performance in executive functions using the Behavioural Assessment of the Dysexecutive Syndrome (BADS) in elder controls and mild AD patients, and to analyze its applicability in our environment. Methods: The BADS was performed by 17 healthy elders and 17 early AD patients matched for age, schooling and gender. Results: There were significant differences among controls and AD patients on MMSE scores, and in measures of executive functions, memory, and motor speed. Some sub items of BADS (rule shift cards, modified six elements, total score, standard, standard by age and overall classification by age) were also different between groups. Differences were also significant on the Dysexecutive Questionnaire (DEX) of BADS self-ratings and other-ratings. Conclusion: BADS was efficacious in detecting executive deficits in this sample, as confirmed by other executive functions tests applied.
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Stabouli, Stella, Katerina Chrysaidou, Athanasia Chainoglou, Dimos Gidaris, Vasilios Kotsis, and Dimitrios Zafeiriou. "Uric Acid Associates With Executive Function in Children and Adolescents With Hypertension." Hypertension 77, no. 5 (May 2021): 1737–44. http://dx.doi.org/10.1161/hypertensionaha.120.16761.
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Observational studies show that serum uric acid levels associate with cardiometabolic risk factors and subclinical target organ damage. The aim of the present study is to investigate the association of traditional cardiometabolic risk factors and uric acid with the executive performance in children and adolescents. Ninety-nine children and adolescents aged 5 to 18 years referred for assessment of primary hypertension were included. Traditional cardiometabolic risk factors, uric acid, and ambulatory blood pressure parameters were assessed. Executive performance was assessed by the validated Behavior Rating Inventory of Executive Function parent questionnaire. Serum uric acid correlated with cardiometabolic parameters, daytime and nighttime systolic blood pressure. High uric acid levels and ambulatory hypertension were associated with behavior regulation independently of other cardiometabolic risk factors or presence of metabolic syndrome. Participants with combined hypertension and high uric acid levels presented the lowest behavior regulation performance. Children with high uric acid had worse behavior regulation indices T scores with estimated marginal means 56.47 (95% CI, 51.68–61.27) compared with 49.22 (95% CI, 45.91–52.53) in those with low uric acid levels ( P =0.023, adjusted for age, sex, nighttime systolic blood pressure, daytime and nighttime heart rate). Mediation analysis showed that part of the effect of high uric acid levels on behavior regulation was mediated by nighttime systolic blood pressure. In conclusion, we found a positive association of serum uric acid with worse executive performance in children at risk for primary hypertension. Extending these cross-sectional findings with longitudinal studies may determine whether high uric acid levels increases the risk of cognitive decline in youth.
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Elias, Rebecca, Haley G. Murphy, K. Amber Turner, and Susan W. White. "Feasibility and Preliminary Efficacy of an Adapted Transdiagnostic Treatment for Children With Executive Function Deficits." Journal of Cognitive Psychotherapy 33, no. 4 (September 30, 2019): 343–56. http://dx.doi.org/10.1891/0889-8391.33.4.343.
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Few psychological interventions exist to target executive function difficulties in children and adolescents. The current study modified the Unstuck and On Target! intervention protocol for use in an outpatient clinic setting with a diagnostically diverse group of participants. Participants engaged in a 10-week child and parent group treatment with assessment measurement at pre- and post-treatment. Assessments consisted of parent-report questionnaires, clinician-administered tasks, and treatment fidelity ratings. Results suggest that the modified intervention was delivered with high fidelity and is feasible and acceptable in a transdiagnostic sample. Although preliminary, efficacy appears promising and suggests that parent-rated executive function, as well as behavioral and emotional challenges, are amenable to change as a result of intervention participation. The results imply that the modified intervention has merit, and should be further explored within the context of larger studies.
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Tomaszewski Farias, Sarah, Jason Gravano, Alyssa Weakley, Maureen Schmitter-Edgecombe, Danielle Harvey, Dan Mungas, Michelle Chan, and Tania Giovannetti. "The Everyday Compensation (EComp) Questionnaire: Construct Validity and Associations with Diagnosis and Longitudinal Change in Cognition and Everyday Function in Older Adults." Journal of the International Neuropsychological Society 26, no. 3 (October 31, 2019): 303–13. http://dx.doi.org/10.1017/s135561771900119x.
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AbstractObjective:The Everyday Compensation scale (EComp) is an informant-rated questionnaire designed to measure cognitively based compensatory strategies that support both everyday memory and executive function in the context of completing instrumental activities of daily living (IADLs). Although previous findings provided early support for the usefulness of the initial version of EComp, the current paper further describes the development, refinement, and validation of EComp as a new assessment tool of compensation for IADLs.Method:Confirmatory factor analysis (CFA) was used to examine its factor structure. Convergent and predictive validity was evaluated by examining the relationship between EComp and markers of disease, including diagnosis, cognitive change, and trajectories of functional abilities.Results:CFA supported a general compensation factor after accounting for variance attributable to IADL domain-specific engagement. The clinical groups differed in compensatory strategy use, with those with dementia using significantly fewer compensatory strategies as compared to individuals with normal cognition or mild cognitive impairment. Greater levels of compensation were related to better cognitive functions (memory and executive function) and functional abilities, as well as slower rates of cognitive and functional decline over time. Importantly, higher levels of compensation were associated with less functional difficulties and subsequently slower rate of functional decline independent of the level of cognitive impairment.Conclusions:Engagement in compensatory strategies among older adults has important implications for prolonging functional independence, even in those with declining cognitive functioning. Results suggest that the revised EComp is likely to be useful in measuring cognitively based compensation in older adults.
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Schantz, Susan L., Anne M. Sweeney, Joseph C. Gardiner, Harold E. B. Humphrey, Robert J. McCaffrey, Donna M. Gasior, K. R. Srikanth, and Marvin L. Budd. "Neuropsychological Assessment of an Aging Population of Great Lakes Fisheaters." Toxicology and Industrial Health 12, no. 3-4 (May 1996): 403–17. http://dx.doi.org/10.1177/074823379601200312.
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Because of the decline in central nervous system function that occurs with age, older people may be at greater risk of neurological dysfunction following exposure to neurotoxic contaminants in the environment. This study wasdesigned to assess the neuropsychological functioning of a group of 50-90- year-old fisheaters exposed to polychlorinated biphenyls (PCBs) through Great Lakes fish consumption, and a group of age- and sex-matched nonfisheaters selectedfrom the Michigan Department of Public Health's established cohort of fisheaters and nonfisheaters. A neuropsychological assessment battery, demographic interview, and fish consumption questionnaire were developed and piloted on similarly aged men and women in the Lansing and Detroit, Michigan, areas. The assessment battery included tests of motor function, memory and learning, executive functions, and visual-spatial functions, and took approximately two hours to administer. Most of the tests included in the battery have been shown to be sensitive to subtle, age-related declines in cognitive and motor function. The demographic questionnaire included questions on a number of important control variables that could influence the neuropsychological end points that were assessed in the study. These included demographic background, alcohol consumption, tobacco use, prescription and nonprescription drug use, medical history (including psychiatric illnesses), employment history, and activity level. The fish consumption questionnaire asked about historical and current consumption of specific fish species from each of the Great Lakes and its tributaries and was based on the fish consumption advisories published in the 1992 Michigan Fishing Guide. The questionnaire also asked about consumption of wild game, fish preparation and cooking methods, serving size, and changes in fish consumption patterns over time. After each subject completed the neuropsychological assessment, demographic interview, and fish consumption questionnaire, a blood sample was collected for analysis of PCBs, dichloro diphenyl dichloroethene (DDE), and ten other contaminants frequently detected in Great Lakes fish. Subject recruitment for the study began in July 1993 and was completed in November 1995. The data will be analyzed in two steps: first, to assess differences in confounding variables between fisheaters and nonfisheaters; and secondly, to determine the independent effects of Great Lakes fish consumption, as well as serum PCB and DDE levels, on cognitive and motor function after controlling for all identified covariates. Three indices of PCB exposure—total PCBs, total ortho-substituted PCBs and total coplanar PCBs—will be assessed. These studies should shed light on three questions: 1) Does consumption of contaminated fish from the Great Lakes exacerbate or accelerate the normal age-related decline in cognitive and motor function? 2) Do serum PCB or DDE concentrations predict the degree of behavioral dysfunction? and 3) If PCB exposure is related to behavioral outcomes, which class of PCB congeners, ortho-substituted or coplanar, are responsible for the cognitive and motor deficits?
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Rosenblum, Sara, Irit Ezra Zandani, Tsofia Deutsch-Castel, and Sonya Meyer. "The Child Evaluation Checklist (CHECK): A Screening Questionnaire for Detecting Daily Functional “Red Flags” of Underrecognized Neurodevelopmental Disorders among Preschool Children." Occupational Therapy International 2019 (December 1, 2019): 1–12. http://dx.doi.org/10.1155/2019/6891831.
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Background. Early identification of invisible comorbid neurodevelopmental disorders, such as specific learning disorders, attention deficit hyperactive disorders, and developmental coordination disorders, is crucial to improving children’s daily functional deficits related to executive functions. However, a practical questionnaire to address parents’ concerns is lacking. Aims. To develop a reliable and valid assessment tool that can identify young children at risk for invisible underrecognized neurodevelopmental disorders. This article describes the development and standardization of the Child Evaluation Checklist (CHECK). Methods and Procedures. Participants were 186 children aged 3 to 6 years: 91 with suspected invisible neurodevelopmental disorders, and 95 controls with typical development. Parents completed a demographic questionnaire, the CHECK, and the Behavior Rating Inventory of Executive Function-Preschool Version (BRIEF-P). Outcomes and Results. The CHECK’s construct validity indicated high internal consistency for each part (Part A: α=.94; Part B: α=.90) and moderate-to-high consistency for each of Part A’s four factors. Significant correlations, as well as significant group differences, were found between the CHECK factors and BRIEF-P scores. Conclusions and Implications. Use of the CHECK allows for timely identification of suspicious (“red flags”) invisible neurodevelopmental disorders. It may support parents’ sufficient awareness and knowledge to refer their children for comprehensive evaluation and intervention.
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Shcherbakov, Nikolai, Nataliya Varako, Maria Kovyazina, Yulia Zueva, Maria Baulina, Anatoliy Skvortsov, and Daria Chernikova. "Dynamics of Neuropsychological Symptoms during the Training of Executive Functions in Neurological Patients." Healthcare 9, no. 12 (December 13, 2021): 1716. http://dx.doi.org/10.3390/healthcare9121716.
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Executive function disorder rehabilitation in neurological patients is associated with many difficulties. We investigated the effectiveness of group training, proposed by B. Wilson et al., which has the model of frontal lobes functioning by D. T. Stuss as the theoretical background. The study participants were 16 patients with executive function disorder caused by TBI, strokes, and infections. The training was shortened from 9 weeks to 3 and adopted to the conditions of the rehabilitation centre where the study was held. The evaluation of training effectiveness was carried out by the methods of neuropsychological diagnostics proposed by A. R. Luria as well as standardized quantitative tests (CWIT test, Raven test, FAB) and questionnaires (EBIQ) aimed at assessing the state of executive functions and general well-being. In result positive trends, but not reaching the level of significance, were revealed in the performance of all evaluating methods, with the exception of “arithmetic problems” and “inhibitory control” as part of the FAB test. Statistically significant result was obtained concerning such tests as “counting”, “analysis of story pictures”, and index of total uncorrected errors in the CWIT test. Thus, the results of eventual assessment showed positive dynamic of executive functions state.
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Gustavson, Daniel E., Amy J. Jak, Jeremy A. Elman, Matthew S. Panizzon, Carol E. Franz, Katherine A. Gifford, Chandra A. Reynolds, Rosemary Toomey, Michael J. Lyons, and William S. Kremen. "How Well Does Subjective Cognitive Decline Correspond to Objectively Measured Cognitive Decline? Assessment of 10–12 Year Change." Journal of Alzheimer's Disease 83, no. 1 (August 31, 2021): 291–304. http://dx.doi.org/10.3233/jad-210123.
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Background: Although not strongly correlated with current objective cognitive ability, subjective cognitive decline (SCD) is a risk factor for Alzheimer’s disease. Most studies focus on SCD in relation to future decline rather than objective prior decline that it purportedly measures. Objective: We evaluated whether self-report of cognitive decline—as a continuous measure—corresponds to objectively-assessed episodic memory and executive function decline across the same period. Methods: 1,170 men completed the Everyday Cognition Questionnaire (ECog) at mean age 68 assessing subjective changes in cognitive ability relative to 10 years prior. A subset had mild cognitive impairment (MCI), but MCI was diagnosed without regard to subjective decline. Participants completed up to 3 objective assessments of memory and executive function (M = 56, 62, and 68 years). Informant-reported ECogs were completed for 1,045 individuals. Analyses controlled for depression and anxiety symptoms assessed at mean age 68. Results: Participant-reported ECog scores were modestly associated with objective decline for memory (β= –0.23, 95%CI [–0.37, –0.10]) and executive function (β= –0.19, 95%CI [–0.33, –0.05]) over the same time period. However, these associations were nonsignificant after excluding MCI cases. Results were similar for informant ratings. Participant-rated ECog scores were more strongly associated with concurrent depression and anxiety symptoms, (β= 0.44, 95%CI [0.36, 0.53]). Conclusion: Continuous SCD scores are correlated with prior objective cognitive changes in non-demented individuals, though this association appears driven by individuals with current MCI. However, participants’ current depression and anxiety ratings tend to be strongly associated with their SCD ratings. Thus, what primarily drives SCD ratings remains unclear.
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Meador, Kimford J., Page B. Pennell, Ryan C. May, Carrie A. Brown, Gus Baker, Rebecca Bromley, David W. Loring, and Morris J. Cohen. "Effects of periconceptional folate on cognition in children of women with epilepsy." Neurology 94, no. 7 (December 23, 2019): e729-e740. http://dx.doi.org/10.1212/wnl.0000000000008757.
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ObjectiveEmerging evidence suggests potential positive neuropsychological effects of periconceptional folate in both healthy children and children exposed in utero to antiseizure medications (ASMs). In this report, we test the hypothesis that periconceptional folate improves neurodevelopment in children of women with epilepsy by re-examining data from the Neurodevelopmental Effects of Antiepileptic Drugs (NEAD) study.MethodsThe NEAD study was an NIH-funded, prospective, observational, multicenter investigation of pregnancy outcomes in 311 children of 305 women with epilepsy treated with ASM monotherapy. Missing data points were imputed with Markov chain Monte Carlo methods. Multivariate analyses adjusted for multiple factors (e.g., maternal IQ, ASM type, standardized ASM dose, and gestational birth age) were performed to assess the effects of periconceptional folate on cognitive outcomes (i.e., Full Scale Intelligence Quotient [FSIQ], Verbal and Nonverbal indexes, and Expressive and Receptive Language indexes at 3 and 6 years of age, and executive function and memory function at 6 years of age).ResultsPericonceptional folate was associated with higher FSIQ at both 3 and 6 years of age. Significant effects for other measures included Nonverbal Index, Expressive Language Index, and Developmental Neuropsychological Assessment Executive Function at 6 years of age, and Verbal Index and Receptive Language Index at 3 years of age. Nonsignificant effects included Verbal Index, Receptive Index, Behavior Rating Inventory of Executive Function–Parent Questionnaire Executive Function, and General Memory Index at 6 years of age, and Nonverbal Index and Expressive Index at 3 years of age.ConclusionsUse of periconceptional folate in pregnant women with epilepsy taking ASMs is associated with better cognitive development.ClinicalTrials.gov identifier:NCT00021866.
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Joyner, Chelsea, and Paul D. Loprinzi. "Longitudinal Effects of Personality on Physical Activity Among College Students: Examining Executive Function as a Potential Moderator." Psychological Reports 121, no. 2 (August 11, 2017): 344–55. http://dx.doi.org/10.1177/0033294117726076.
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Objective The purpose of this study was to examine the relationship between personality and physical activity, with a specific focus on whether executive function moderates this relationship. Methods One hundred twenty-six young adults provided complete data at baseline and the five-month follow-up assessment. Executive function was assessed via the parametric Go/No-Go computer task; outcome measures of parametric Go/No-Go were mean reaction time and percent of correct target detection across executive function tasks (simple rule and repeating rule). Personality and moderate-to-vigorous physical activity were assessed via validated questionnaires; one-week test–retest was established on a random sample of the participants, with pedometry employed in the subsample. Results Individuals with a higher baseline conscientiousness personality type had greater five-month follow-up moderate-to-vigorous physical activity (β = 18.5; 95% confidence interval: 5.3, 31.7; p = .006). There was no evidence of an interaction effect for personality trait and executive function on five-month follow-up moderate-to-vigorous physical activity. Conclusion The personality trait conscientiousness was associated with greater moderate-to-vigorous physical activity. However, there was no evidence to suggest that executive function moderates the role between personality and moderate-to-vigorous physical activity. Thus, if confirmed by future work, personality may exert its effects on moderate-to-vigorous physical activity independent of executive function level.
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Huhdanpää, Hanna, Liisa Klenberg, Hannu Westerinen, Paula Hannele Bergman, and Eeva Tuulikki Aronen. "Impairments of executive function in young children referred to child psychiatric outpatient clinic." Clinical Child Psychology and Psychiatry 24, no. 1 (July 27, 2018): 95–111. http://dx.doi.org/10.1177/1359104518786537.
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Few studies have reported on the quantity and quality of executive function (EF) deficits in young children referred to child psychiatric outpatient clinic with multiple psychiatric symptoms. We evaluated the EF deficits with the Attention and Executive Function Rating Inventory–Preschool (ATTEX-P) filled out by day care teachers for 4- to 7-year-old clinical group ( n = 171) and reference group ( n = 709). Family background information was collected from all families by parent questionnaire. Diagnoses of the referred children were collected from medical records. Clinical group exhibited higher mean ranks across the ATTEX-P Total score and all nine subscales than reference group ( p < .001). Most of the children in the clinical group (58.5%) showed a significant amount of EF deficits (ATTEX-P Total score over clinical cut-off) including distractibility (55.6%) and impulsivity (53.8%) regardless of their diagnoses. In a multiple logistic regression model (controlling for age, gender and parental education), children in the clinical group had increased risk (odds ratio (OR)) = 10.6, 95% confidence interval (CI) = [6.88, 16.2], p < .001) for scoring over the clinical cut-off point on the ATTEX-P Total score. Assessment of EFs should be a routine part of the treatment plan in young children referred to child psychiatric outpatient clinic as it may guide the treatment choices.
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Faleschini, Sabrina, Sheryl Rifas-Shiman, Henning Tiemeier, Emily Oken, and Marie-France Hivert. "Associations of Prenatal and Postnatal Maternal Depressive Symptoms with Offspring Cognition and Behavior in Mid-Childhood: A Prospective Cohort Study." International Journal of Environmental Research and Public Health 16, no. 6 (March 20, 2019): 1007. http://dx.doi.org/10.3390/ijerph16061007.
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Exposure to maternal depressive symptoms in the peri-pregnancy periods may be associated with poorer child development, but research is often limited to only maternal assessments of behavior and cognition. This study investigates the specific periods of prenatal and postnatal exposure to maternal depressive symptoms in association with child development using reports from teachers and mothers. This study is based on 1225 mother–child pairs from Project Viva, a prospective pre-birth cohort study. Mothers reported depressive symptoms on the Edinburgh Postpartum Depression Scale (EPDS) in mid-pregnancy as well as at 6 months and 12 months postpartum. Teachers and mothers reported child executive functions using the Behavioral Rating Inventory of Executive Function (BRIEF) and behavior using the Strengths and Difficulties Questionnaire (SDQ). Children completed the Kaufman Brief Intelligence Test (KBIT-2), the Wide Range Assessment of Visual Motor Abilities (WRAVMA), and the Visual Memory Index of the Wide Range Assessment of Memory and Learning (WRAML). We used multivariable linear regression models to examine associations of prenatal and postpartum depressive symptoms with outcomes. Many of the crude associations observed were attenuated after adjusting for demographic factors and maternal IQ, yet some remained significant. For example, high prenatal maternal depressive symptoms were associated with poorer scores on the BRIEF Behavior Regulation Index and some SDQ scales based on reports from teachers and mothers. High prenatal maternal depressive symptoms were associated with poorer behavioral development. Postpartum symptoms did not show strong associations with outcomes once we adjusted for the prenatal period.
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Kiambarua, Kenneth Gitiye, Peter Mwiti Mwiti, and Esther Thuba Thuba. "ASSESSMENT ON THE EFFECT OF EXECUTIVE FUNCTIONING DISORDERS IN VULNERABILITY TO DEPRESSION AMONG ADOLESCENTS IN SECONDARY SCHOOLS IN MERU COUNTY, KENYA." Journal of Advanced Psychology 4, no. 1 (August 7, 2022): 19–36. http://dx.doi.org/10.47941/japsy.980.
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Purpose: Assessment on the effect of executive functioning disorders in vulnerability to depression among adolescents in secondary schools in Meru County, Kenya.
Methodology: The study adopted descriptive research design to gather both qualitative and quantitative data. Secondary schools were sampled using proportionate stratified sampling method to obtain 27 secondary schools in Meru County. The principals/deputy principals and counseling teachers were interviewed. Mathematics and English teachers answered a questionnaire, while the students were assessed using depression tool. Pretesting of data collecting instruments was done in 3 schools in the neighboring Tharaka Nithi County; Ikuu girls’ secondary school, Chuka boys’ high school and Ndagani mixed day secondary school. Data was analyzed using descriptive statistics such as frequency, percentage and median. Additionally, inferential statistics such as linear regression and multiple regressions inclusive of regression coefficients were established. SPSS was used to analyze the data presented. The findings were presented using tables, explanations, and diagrams. Content analysis method was used for qualitative analysis purposes.
Results: The questionnaires results indicated that majority, 128 (89%) of Mathematics and English teachers strongly agreed that the school was keen on ensuring that corporal punishment is not administered hence alternative ways so as to reduce mental effect such as cognitive deficits (mean of 5). Nevertheless, 68(47%) strongly disagreed and 38(26%) disagreed that there were systems in school for students to speak out when they are undergoing physical and mental torture (mean of 2). On the interview results, principals and counseling teachers indicated that students with executive functions disorder got bullied, had low self-esteem, indiscipline issues such as fighting the students laughing at their weaknesses, and got low grades. The intervention measures implemented by the school included observing and singling out cases. The R value was 0.943 and the R-square was 0.890. This meant that executive functioning disorder had an 89% influence on vulnerability to depression whereas 11% was as a result of other factors not addressed in the study. The significance value was 0.000 hence below 0.05. This made the study reject the null hypothesis that executive functioning deficits have no statistically significant effect on vulnerability to depression among adolescents in secondary school in Meru County, Kenya.
Conclusion: Though there were awareness campaigns on mental issues as a result of drug and substance abuse, there still lacked awareness made on mental issues due to cognitive deficits making students unable to multitask, manage time and lack attention. This lack of awareness was caused due to unavailability of systems and communication channels that students suffering from cognitive deficits could speak up on to get help.
Recommendations: The study recommends that on executive function disorder, the management of the school should beef up on creating awareness of how mental issues can lead to drug and substance abuse by the students. There should be provision of finances by the ministry of education to schools to be able to have print media such as posters, magazines, newsletters and pamphlets on what executive function disorders are, how can one tell they suffer from them and the various treatment methods in place.
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Borgnis, Francesca, Francesca Baglio, Elisa Pedroli, Federica Rossetto, Mario Meloni, Giuseppe Riva, and Pietro Cipresso. "A Psychometric Tool for Evaluating Executive Functions in Parkinson’s Disease." Journal of Clinical Medicine 11, no. 5 (February 22, 2022): 1153. http://dx.doi.org/10.3390/jcm11051153.
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Recently, there has been an increasing interest in using 360° virtual-reality video for an ecologically valid assessment of executive functioning in the neurologic population. In this framework, we have developed the EXecutive-functions Innovative Tool (EXIT 360°), an original 360°-based instrument for a multicomponent, ecologically valid evaluation of executive functioning in Parkinson’s Disease (PD). This work aimed to test the usability and user experience of EXIT 360° in patients with PD (PwPD). Twenty-seven PwPD and twenty-seven healthy controls underwent an evaluation that involved: (1) usability assessment by the System Usability Scale and (2) evaluation of user experience using the ICT—Sense of Presence and User Experience Questionnaire. Results showed a satisfactory level of usability for patients (mean = 76.94 ± 9.18) and controls (mean = 80 ± 11.22), with good scores for usability and learnability. Regarding user experience, patients provided a positive overall impression of the tool, evaluating it as attractive, enjoyable, activating, and funny. Moreover, EXIT 360° showed good pragmatic (e.g., efficient, fast, clear) and hedonic quality (e.g., exciting, interesting, and creative). Finally, PwPD considered EXIT 360° as an original tool with high ecological validity (mean = 4.29 ± 0.61), spatial presence (mean = 3.11 ± 0.83) and engagement (mean = 3.43 ± 0.54) without relevant adverse effects. Technological expertise had no impact on performance. Overall, EXIT 360° appeared to be a usable, easy-to-learn, engaging, and innovative instrument for PD. Further studies will be conducted to deepen its efficacy in distinguishing between healthy subjects and patients with executive dysfunctions.
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Ji, Xiaopeng, and Jennifer Saylor. "242 Sufficient sleep attenuates the impact of COVID-19 pandemic on executive function decline in late adolescents and young adults." Sleep 44, Supplement_2 (May 1, 2021): A96—A98. http://dx.doi.org/10.1093/sleep/zsab072.241.
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Abstract Introduction Executive function (EF), which shows continued development into early adulthood, is essential to build resilience to cope with COVID-19-related social and environmental changes. However, how sleep interacts with the pandemic on affecting EF remains unclear, particularly among late adolescents and young adults. This study examined (1) the impact of COVID-19 pandemic on sleep and EF and (2) whether sleep moderated pandemic-related changes in EF among young people aged 18-21 years old. Methods Between April and May 2020, university students with baseline data on sleep and EF (Spring and Fall semesters in 2019) available were invited to this follow-up study. Sleep duration, mid-sleep times, social jetlag (the difference between mid-sleep times on weekdays and weekends) and sleep latency were assessed using 7-day sleep diaries. Participants also completed the Pittsburgh Sleep Quality Index (PSQI), the Morningness/Eveningness Questionnaire, and the Behavior Rating Inventory of Executive function which yielded Global Executive Composite (GEC) scores. Paired t-test and multilevel random-effects models (STATA 16.0) estimated the associations. Covariates in multilevel models included age, sex, race, family income, parental education, COVID status, and health behaviors. Results Forty participants (19.25±1.12 years old) had paired data before and during COVID-19 pandemic. Participants slept 24 min longer (t= -2.07, p=0.03) but had increased sleep latency (t=-1.83, p=0.07) during the pandemic compared to pre-COVID baseline. Mid-sleep times shifted 40 min later (t= -3.22, p=0.003) during the pandemic. In multilevel models, GEC scores increased during pandemic (b=3.15, p=0.03) versus baseline, suggesting decreased executive function. Sleep duration (β=-4.72, p=0.03) significantly interacted with assessment time (before/during COVID-19), with increasing sleep duration attenuating the decline in EF during pandemic versus baseline. Although there was no interaction with COVID-19 pandemic, poor sleep quality (PSQI>5) was independently associated with decreased EF (B=4.69, p=0.02). Other sleep variables were not associated with EF nor moderators. Conclusion Compared with pre-COVID-19 baseline, young people report longer sleep duration, later sleep phase, increased sleep latency, and worse executive function during the pandemic. Sufficient sleep represents a resilience factor against executive function decline during this unprecedented crisis. Support (if any) No
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H, Clark, Schroeder R, and Martin P. "A-200 Which Domains of Neuropsychological Functioning are Most Strongly Related to Impairment in Instrumental Activities of Daily Living?" Archives of Clinical Neuropsychology 35, no. 6 (August 28, 2020): 995. http://dx.doi.org/10.1093/arclin/acaa068.200.
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Abstract Objective The current study investigated relationships between neuropsychological test findings and instrumental activities of daily living (IADLs) in a mixed sample of Mild and Major Neurocognitive Disorder (NCD). Method Archival data from a memory disorder clinic were analyzed. Patients (n = 68, mean age = 72.3, mean education = 13.2 years, 26.5% Mild NCD, 73.5% Major NCD) minimally completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Delis-Kaplan Executive Function System (D-KEFS). Information on IADLs was obtained from family members via the Functional Activities Questionnaire (FAQ). Spearman correlations were calculated between individual IADLs from the FAQ, total FAQ ratings, RBANS index scores, and a composite executive functioning score (average scaled score on DKEFS Trail Making, Verbal Fluency, and Tower). Results Executive functioning was the only cognitive domain that significantly correlated (p < .05) with total FAQ ratings. However, all cognitive domains except language significantly correlated with individual IADLs. Tracking current events correlated with immediate memory, while financial management correlated with delayed memory. Attending to, understanding, and discussing TV, books, and magazines correlated with executive functioning and immediate and delayed memory. Remembering events correlated with attention and executive functioning. Shopping alone correlated with immediate memory, attention, and executive functioning, while operating basic kitchen appliances correlated with visuospatial skills, attention, and executive functioning. Traveling also correlated with visuospatial skills and executive functioning. Conclusions Executive functioning was the only domain associated with overall daily functioning; however, all domains except language corresponded with individual IADLs. Current findings highlight the utility of neuropsychological test findings in understanding the nuances of deficits in daily functioning.
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Medrano-Martinez, Pablo, and Rosa Peraita-Adrados. "Neuropsychological Alterations in Narcolepsy with Cataplexy and the Expression of Cognitive Deficits." Journal of the International Neuropsychological Society 26, no. 6 (December 12, 2019): 587–95. http://dx.doi.org/10.1017/s1355617719001334.
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AbstractObjectives:The objective of our study was to assess attention processes and executive function in patients with narcolepsy with cataplexy (NT1). To do so, we compared the results with those of a control group from the general population using an extensive neuropsychological test battery.Methods:We studied 28 patients with NT1 and 28 healthy control participants matched for age, gender, and educational level. They all completed questionnaires on sleepiness, anxiety, and depression symptoms. In addition, they underwent neuropsychological tests. The ability to maintain attention was assessed using three computer tasks with different levels of complexity.Results:Patients had significantly more daytime sleepiness than controls. A significant negative correlation between depression and disease duration was found in NT1 patients. The results of the anxiety questionnaire correlated with the presence of sleep paralysis. There were significant differences in information processing speed subtasks. Patients made significantly more omissions and generally reacted slower and more variably than controls in computerized tasks. As for executive function, patients performed worse in phonologic fluency tasks than controls. However, when the influence of processing speed on fluency tasks was statistically controlled, part of this significant difference disappeared.Conclusions:Our results indicate that the negative correlation between depression and disease duration probably reflects progressive adaptation to the functional burden of the disease. Information processing speed plays a fundamental role in the expression of cognitive deficits. We emphasized the need to control the influence of processing speed and sustained attention in the neuropsychological assessment of NT1 patients.
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Fahy, Jill K. "Assessment of Executive Functions in School-Aged Children: Challenges and Solutions for the SLP." Perspectives on School-Based Issues 15, no. 4 (December 2014): 151–63. http://dx.doi.org/10.1044/sbi15.4.151.
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The assessment of executive function (EF) deficits in school-aged children has become an area of increased interest and need for speech-language pathologists (SLPs) working in educational settings. Various challenges exist that complicate the assessment of executive dysfunction (EDF) in students, among them the fact that EDF is present within a heterogeneous mix of developmental disorders. The resulting communication, behavioral, and academic problems addressed by the SLP, educators, and parents are frequently an interwoven mix of language disorders, social disorders, learning disorders, and/or mental health disorders—each of which is known to present with EDF. Furthermore, there is no one specific profile of EDF. The SLP must evaluate for each student's individual EF profile, while also taking into account foundations of language or social cognition. Questionnaires, informal observations, standardized rating scales, and standardized EF tests are available that can provide diagnostic insight for SLPs working with students who display EDF.
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H, Clark, Schroeder R, and Martin P. "A-168 Do Family Members’ Subjective Perceptions of Decline in Executive Functioning Skills Reflect Objective Cognitive Dysfunction?" Archives of Clinical Neuropsychology 35, no. 6 (August 28, 2020): 962. http://dx.doi.org/10.1093/arclin/acaa068.168.
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Abstract Objective On behavior rating scales completed by family members, executive functioning is often operationalized in terms of subdomain abilities (e.g., problem-solving, multitasking, and organizing). It is unclear, however, how well collateral assessments of these abilities reflect patients’ actual executive functioning. The current study investigated the relationship between family members’ reported perceptions of change in patients’ problem-solving, multitasking, and organizing abilities and objective neuropsychological test findings. Method Patients undergoing dementia evaluations (n = 56, mean age = 71.4, mean education = 13.0 years) minimally completed subtests from the Delis-Kaplan Executive Function System (D-KEFS; Trail Making, Verbal Fluency, Color-Word, Tower) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Information from family members was obtained via a questionnaire asking about degrees of change (no change, mild change, moderate change, or severe change) in problem-solving, multitasking, and organizing. Spearman correlations were calculated between family members’ perceptions of change and cognitive dysfunction, as measured by D-KEFS (subtests and combined averaged scaled score) and RBANS index scores. Results Perceived changes in problem-solving, multitasking, and organizing did not significantly correlate at p < .05 with either D-KEFS subtest scores or the combined scaled score. Perceived changes significantly correlated with RBANS Immediate Memory (problem-solving: rs = −.338, p = .014; multitasking: rs = −.323, p = .017; organizing: rs = −.293, p = .028) and Language (problem-solving: rs = −.306, p = .027) indices. Conclusions Family members’ perceptions of change in problem-solving, multitasking, and organizing did not correspond with objective executive dysfunction observed on neuropsychological testing. Future research should attempt to cross-validate these findings. If cross-validated, results would suggest limited utility in using these terms to operationalize executive functioning on behavior rating scales.
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Bryk, Kelsey, Scott Passalugo, and Thomas A. Buckley. "Effects of Persistent Concussion Symptoms on Executive Function in Working-aged Adults using a Novel Sensorimotor Assessment Tool." Neurology 95, no. 20 Supplement 1 (November 16, 2020): S13.3—S14. http://dx.doi.org/10.1212/01.wnl.0000719996.56412.9a.
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ObjectiveTo examine neurocognitive performance of persistent concussion symptom patients using a novel sensorimotor technology.BackgroundIn patients with persistent concussion symptoms, neurocognitive deficits have been routinely identified; however, most of the current literature focuses on athletes and military veterans. Middle aged community members face unique challenges related to jobs, family, and transportation which can all be adversely affected by neurocognitive deficits.Design/MethodsThirteen adults (44.3 ± 12.6 years) with self-reported persistent-concussion symptoms (PCS) at least 3 months post-injury, and thirteen sex and age matched healthy controls (37.5 ± 8.8 years) were recruited. Participants performed the Trail-Making Test A (TMT-A) and Trail-Making Test B (TMT-B) on a novel sensorimotor assessment tool, the KINARM (BKIN Technologies, Kingston, ON, Canada). Using their dominant hand, TMT-A required participants to connect numbered dots in ascending order as quickly as possible. TMT-B required connecting dots with either a number or letter inside, in an alternating number-letter fashion (i.e.,: 1-A-2-B-3-C…). Total number of symptoms and a symptom severity score were assessed using the Rivermead Post Concussion Symptoms Questionnaire (RPQ). An independent samples t-test was used to analyze group differences of total time to completion, dwell time, and number of errors.ResultsAs expected, PCS patients had a significantly higher number of symptoms and severity score (PCS: 13.4 ± 2.3 and 36.2 ± 14.5, respectively; Controls: 3.4 ± 3.7 and 5.3 ± 5.6, respectively, p < 0.001). PCS patients were significantly slower on TMT-A (46.3 ± 20.1 sec; and 34.7 ± 6.5 sec respectively, p = 0.047). There were no group differences in TMT-B.ConclusionsOur results suggest that neurocognitive function may remain unaffected by persistent concussion symptoms in working-aged adults. The lack of task performance differences may be a result of neurocognitive function recovery, or the need for a more sensitive task to assess neurocognitive function in this population.
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Yu, Ruby, Grace Leung, and Jean Woo. "Randomized Controlled Trial on the Effects of a Combined Intervention of Computerized Cognitive Training Preceded by Physical Exercise for Improving Frailty Status and Cognitive Function in Older Adults." International Journal of Environmental Research and Public Health 18, no. 4 (February 3, 2021): 1396. http://dx.doi.org/10.3390/ijerph18041396.
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(1) Objective: This study examined the effects of a combined intervention of Brainastic computerized cognitive training (CCT) preceded by physical exercise (PE) for improving frailty status and cognitive function in older adults. (2) Methods: Older adults aged 50 years or older attending elderly centers, without frailty/history of cognitive impairment, were randomly allocated into either a 12-week (i) multi-domain CCT + PE (n = 117), (ii) two-domain CCT + PE (n = 116) or (iii) video watching + PE (i.e., control, n = 114). Brainastic is an online application for cognitive training through video games. The multi-domain CCT targeted memory, attention, executive function, flexibility and visuospatial ability while the two-domain CCT targeted memory and attention. PE included both aerobic and resistance exercises. Outcomes were changes in frailty levels as measured with a simple frailty questionnaire (FRAIL), global cognition as measured with the Rapid Cognitive Screen (RCS), total learning and verbal memory abilities as measured with the Hong Kong List Learning Test (HKLLT), and executive functions as measured with the Frontal Assessment Battery (FAB) over 12 weeks. (3) Results: Participants in the intervention groups (multi-/two-domain CCT + PE) showed greater improvements in frailty status, total learning ability and verbal memory ability than control participants (all p < 0.05). The multi-domain CCT did not outperform the two-domain CCT in improving frailty status or cognitive function. The training effects were independent of the baseline cognition of the participants. (4) Conclusions: A combined intervention of multi-/two-domain CCT preceded by PE seemed to convey benefit over video watching preceded by PE in improving frailty status and cognitive function among older adults attending elderly centers.
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Liu, Zhilan, Zhijie He, Jing Yuan, Hua Lin, Conghui Fu, Yan Zhang, Nian Wang, et al. "Application of Immersive Virtual-Reality-Based Puzzle Games in Elderly Patients with Post-Stroke Cognitive Impairment: A Pilot Study." Brain Sciences 13, no. 1 (December 31, 2022): 79. http://dx.doi.org/10.3390/brainsci13010079.
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Background: The society is aging in China, and the cognitive level of elderly post-stroke patients gradually declines. Face-to-face cognitive functional training is no longer sufficient. Immersive virtual reality (IVR) is a promising rehabilitation training device. In this study, we developed an IVR-based puzzle game to explore its effectiveness, feasibility, and safety in elderly stroke patients with cognitive dysfunction. Methods: A total of 30 patients with mild post-stroke cognitive impairment after stroke were randomly assigned to a control or IVR group. Patients in both groups received routine rehabilitation therapy. Patients in the control group received traditional cognitive training, and those in the IVR group received IVR-based puzzle game therapy. Before and after treatment, Montreal cognitive assessment (MOCA), trail-making test-A (TMT-A), digit symbol substitution test (DSST), digital span test (DST), verbal fluency test (VFT), and modified Barthel index (MBI) were evaluated in both groups. In addition, the IVR group was administered a self-report questionnaire to obtain feedback on user experience. Results: There was no significant difference in the baseline data between the two groups. After six weeks of treatment, the cognitive assessment scores were improved in both groups. Moreover, the IVR group showed more improvements than the control group in the DSST (Z = 2.203, p = 0.028 < 0.05, η2 = 0.16); MOCA (T = 1.186, p = 0.246 > 0.05, d = 0.44), TMT-A (T = 1.791, p = 0.084 > 0.05, d = 0.65), MBI (T = 0.783, p = 0.44 > 0.05, d = 0.28), FDST (Z = 0.78, p = 0.435 > 0.05, η2 = 0.02), BDST (Z = 0.347, p = 0.728 > 0.05, η2 = 0.004), and VFT(Z = 1.087, p = 0.277 > 0.05, η2 = 0.039) did not significantly improve. The significant difference in DSST represents an improvement in executive function and visual–spatial cognitive characteristics. The other assessment scores did not show such features. Therefore, we did not observe significant differences through this measure. According to the results of the self-report questionnaire, most of the patients were satisfied with the equipment stability and training content. Several individuals reported mild adverse reactions. Conclusions: This pilot study suggests that IVR-based puzzle games are a promising approach to improve post-stroke cognitive function, especially executive cognitive function, and visual–spatial attention in older adults.
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Dupuy, Emma, Florent Besnier, Christine Gagnon, Juliana Breton, Catia Lecchino, Mathieu Gayda, and Louis Bherer. "PHYSICAL FITNESS MODERATES THE AGE-RELATED ASSOCIATION BETWEEN EXECUTIVE FUNCTIONING AND MOBILITY." Innovation in Aging 6, Supplement_1 (November 1, 2022): 645. http://dx.doi.org/10.1093/geroni/igac059.2386.
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Abstract In older adults, executive functions are important for daily-life function and mobility. Evidence suggests that the relationship between cognition and mobility is dynamic and could vary according to individual factors, but whether cardiorespiratory fitness reduces the age-related increase of interdependence between mobility and cognition remains unexplored. One hundred eighty-nine participants (aged 50-87) were divided into three groups according to their age: middle-aged (MA; < 65), young older adults (YOA; 65-74), and old older adults (OOA; ≥75). Participants performed Timed Up and Go and executive functioning assessments (Oral Trail Making Test and Phonologic verbal fluency) remotely by videoconference. Participants completed the Matthews questionnaire to estimate their cardiorespiratory fitness (VO2 max in ml/min/kg). A three-way moderation was used to address whether cardiorespiratory fitness interacts with age to moderate the relationship between cognition and mobility. Results showed that the cardiorespiratory fitness x age interaction moderated the association between executive functioning and mobility (β = -.05, p = .047) (R2 = .18, p <.0001). At lower levels of physical fitness (< 19.16 ml/min/kg), executive functioning significantly influenced YOA’s mobility (β = -.48, p = .004) and to a greater extent OOA’s mobility (β = -.96, p = .002). Our results support the idea of a dynamic relationship between mobility and executive functioning during aging and suggest that physical fitness could play a significant role in reducing their interdependency.
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Borgnis, Francesca, Francesca Baglio, Elisa Pedroli, Federica Rossetto, Sara Isernia, Lidia Uccellatore, Giuseppe Riva, and Pietro Cipresso. "EXecutive-Functions Innovative Tool (EXIT 360°): A Usability and User Experience Study of an Original 360°-Based Assessment Instrument." Sensors 21, no. 17 (August 31, 2021): 5867. http://dx.doi.org/10.3390/s21175867.
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Over the last few decades, several studies have shown the feasibility, acceptability, and efficacy of VR-based instruments in the early evaluation of executive dysfunction (ED) in psychiatric and neurologic conditions. Due to the negative impact of ED in everyday functioning, identifying innovative strategies for evaluating ED allows clinicians to detect executive impairment early and minimize its effects. This work aimed to test the usability and user experience (UX) of EXecutive-functions Innovative Tool 360° (EXIT 360°), a 360°-based tool for assessing ED. Seventy-six healthy subjects underwent an evaluation that involved (1) usability assessment using System Usability Scale and (2) evaluation of UX using the ICT-Sense of Presence and UX Questionnaire. Results showed a satisfactory level of usability (mean = 75.9 ± 12.8), with good scores for usability and learnability. As regards UX, EXIT 360° showed an absence of negative effects (mean = 1.79 ± 0.95) and high scores in ecological validity (mean = 4.32 ± 0.54) and engagement (mean = 3.76 ± 0.56). Moreover, it obtained good scores in efficiency (mean = 1.84 ± 0.84), originality (mean = 2.49 ± 0.71), and attractiveness (mean = 1.93 ± 0.98). Interestingly, demographic characteristics and technological expertise had no impact on the performance (p > 0.05). Overall, EXIT 360° appeared to be a usable, learn-to-use, engaging, and creative tool with irrelevant negative effects. Further studies will be conducted to evaluate these aspects in the clinical population.
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Gibson, William, Asad Makhani, Kathleen F. Hunter, and Adrian Wagg. "Do Older Adults with Overactive Bladder Demonstrate Impaired Executive Function Compared to Their Peers Without OAB?" Canadian Geriatrics Journal 23, no. 4 (November 23, 2020): 329–34. http://dx.doi.org/10.5770/cgj.23.423.
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Background
Maintaining urinary continence is not an automatic process, but relies on continuous processing of sensory signals from the bladder and suppression of the desire to void. Urinary incontinence (UI) and lower urinary tract symptoms (LUTS), including urinary urgency, frequency, and nocturia are highly prevalent among the general population. This prevalence rises in association with increasing age, and this may be in part due to changes in the central nervous system rather than the urinary tract. The aim of this study was to assess if older adults with overactive bladder (OAB) had demonstrable impairment in executive function.
Methods
This was a cross-sectional study comparing the performance of adults aged 65 and over with and without OAB on two cognitive tests, the Trail Making Test B (TMT-B) and simple reaction time (SRT). OAB was defined as urgency, with at least weekly urgency incontinence and a daytime urinary frequency of 8 or more. The control group were defined as a Bladder control Self-Assessment Questionnaire (B-SAQ) score of ≤4.
Results
56 participants were recruited, of whom 35 met criteria for OAB. The OAB group took significantly longer to complete the TMT-B than the control group (103s vs. 77s, p = .003). There was no difference in the SRT
Conclusions
In this sample of older adults, OAB was associated with measurable slower performance on the TMT-B, suggesting that impaired executive function is associated with OAB.