Journal articles on the topic 'Queen Mary Hospital (Hong Kong)'
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Wong, WM, FSK Chu, and WK Tso. "Efficacy of Acrylamido Polyvinyl Alcohol Hydrogel Microspheres for Uterine Artery Embolisation for Leiomyoma." Hong Kong Journal of Radiology 17, no. 4 (December 17, 2014): 228–33. http://dx.doi.org/10.12809/hkjr1414229.
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Suen, Hon Chi, and Francesco Puma. "The Hong Kong Queen Mary Hospital Second Thoracic Surgery Symposium Focused Issue." Journal of Thoracic Disease 10, S16 (June 2018): S1838—S1840. http://dx.doi.org/10.21037/jtd.2018.05.198.
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Saing, Htut, S. T. Fan, K. L. Chan, W. I. Wei, C. M. Lo, G. H. Mya, N. S. Tsoi, et al. "Liver transplantation in children: The experience of Queen Mary Hospital, Hong Kong." Journal of Pediatric Surgery 32, no. 1 (January 1997): 80–83. http://dx.doi.org/10.1016/s0022-3468(97)90100-7.
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Wong, John. "Esophageal resection for cancer in The University of Hong Kong, Queen Mary Hospital, Hong Kong, China (1982–2008)." Journal of Thoracic Disease 10, S16 (June 2018): S1843—S1844. http://dx.doi.org/10.21037/jtd.2018.01.84.
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Hsu, C., W. K. Tso, K. C. Lam, C. Y. Leung, M. Wong, W. F. Ng, and H. Yeung. "Transthoracic fine needle aspiration of lung, experience in Queen Mary Hospital, Hong Kong." Pathology 22 (1990): 22. http://dx.doi.org/10.1016/s0031-3025(16)36380-2.
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Huang, Y.-C., J. Xiao, VYL Leung, WW Lu, Y. Hu, and KDK Luk. "Lumbar intervertebral disc allograft transplantation: healing and remodelling of the bony structure." European Cells and Material 32 (October 19, 2016): 216–27. http://dx.doi.org/10.22203/ecm.v032a14.
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Au, W. Y., A. K. W. Lie, Y. L. Kwong, T. W. Shek, B. R. Hawkins, K. N. Lai, S. C. W. Tang, et al. "Post-transplantation Lymphoproliferative Disease in Chinese: The Queen Mary Hospital Experience in Hong Kong." Leukemia & Lymphoma 43, no. 7 (January 2002): 1403–7. http://dx.doi.org/10.1080/10428190290033341.
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K.Y. Chan, Rebecca, Y. C. Leung, Frankie K.L. Leung, Christian X.S. Fang, Amy K.P. Cheung, Tony K.C. Lau, and Jo Kamen K.M. Fung. "Reliability and validity of the Chinese (Queen Mary Hospital, Hong Kong version) of the Disabilities of the Arm, Shoulder and Hand on patients with upper extremity musculoskeletal disorders in Hong Kong." Hong Kong Journal of Occupational Therapy 32, no. 1 (May 21, 2019): 62–68. http://dx.doi.org/10.1177/1569186119849502.
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Objective This study aimed to translate, culturally adopt and validate a Chinese version of the Disabilities of the Arm, Shoulder and Hand (DASH) for use in patients with upper extremity musculoskeletal diseases in Hong Kong. Methods We followed a standard five-stage process: forward translation, synthesis, backward translation, expert panel review and field-testing to achieve linguistic and conceptual equivalence. The version was officially known as Chinese (Queen Mary Hospital, Hong Kong version) DASH. (Chinese QMH,HK version DASH) ( http://www.dash.iwh.on.ca/sites/dash/public/translations/DASH_Chinese_HK_2013.pdf ). Results Its internal consistency was then evaluated with 138 participants suffering from upper extremity musculoskeletal conditions. The results were high in DASH-Disability/Symptom module (DASH-DS) (Cronbach alpha 0.97), DASH-Work module (DASH-W) (Cronbach alpha 0.97) and DASH-Sports / Performing Arts module (DASH-SM) (Cronbach alpha 0.99). The test-retest reliability was evaluated with a subgroup of participants who had completed the Chinese (QMH,HK version) DASH on two occasions, with a median interval of 6.5 days. The results were excellent among DASH-DS Intraclass Correlation Coefficient (ICC) = 0.98 and DASH-W (ICC = 0.90). Good test-retest reliability was found in DASH-SM (ICC = 0.89). Construct validity of DASH-DS showed good correlation with the sub-domains of physical functioning (r = −.564) and social functioning (r = −.544) of the Short Form 36 Health Survey (SF-36). Similarly, construct validity of DASH-W also showed good correlation with the sub-domains of physical functioning (r = −.510) and bodily pain (r = −.503) of SF-36. Conclusion The Chinese (Queen Mary Hospital, Hong Kong version) Disabilities of the Arm, Shoulder and Hand is considered as a reliable and valid instrument that can provide a standardised measure of patient-centred outcomes for patients with upper extremity musculoskeletal disorders in Hong Kong.
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Saing, Htut, Sheung Tat Fan, Kwong Leung Chan, William Wei, George Hlaing Mya, Chung Mau Lo, and Wei Cheng. "Treatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experience." Tohoku Journal of Experimental Medicine 181, no. 1 (1997): 109–16. http://dx.doi.org/10.1620/tjem.181.109.
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Zhou, Mi, Esther W. Chan, Jo Jo Hai, Chun Ka Wong, Yuk Ming Lau, Duo Huang, Cheung Chi Lam, et al. "Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study." BMJ Open 10, no. 9 (September 2020): e038194. http://dx.doi.org/10.1136/bmjopen-2020-038194.
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IntroductionCurrent international guidelines recommend non-vitamin K oral anticoagulants (NOACs) for stroke prevention among patients with non-valvular atrial fibrillation (AF) at significant ischaemic stroke risk given the superior safety and comparable efficacy of NOACs over warfarin. Nonetheless, the safety and effectiveness of NOACs have not been evaluated in patients with AF with underlying moderate or severe mitral stenosis (MS), hence the recommended stroke prevention strategy remains warfarin therapy.Method and analysisMS remains disproportionately prevalent in Asian countries compared with the developed countries. This prospective, randomised, open-label trial with blinded endpoint adjudication aims to evaluate the safety and efficacy of dabigatran for stroke prevention in AF patients with moderate or severe MS. Patients with AF aged ≥18 years with moderate or severe MS not planned for valvular intervention in the coming 12 months will be randomised in a 1:1 ratio to receive dabigatran 110 mg or 150 mg two times per day or warfarin with international normalised ratio 2–3 in an open-label design. Patients with estimated creatinine clearance <30 mL/min, or with a concomitant indication for antiplatelet therapy will be excluded. The primary outcome is a composite of stroke and systemic embolism. Secondary outcomes are ischaemic stroke, systemic embolism, haemorrhagic stroke, intracranial haemorrhage, major bleeding and death. The estimated required sample size is approximately 686 participants.Ethics and disseminationThe study protocol has been approved by the Institutional Review Board of the University of Hong Kong and Hong Kong West Cluster, Hospital Authority, Hong Kong for Fung Yiu King Hospital, Grantham Hospital, Queen Mary Hospital and Tung Wah Hospital in Hong Kong. Results will be published in peer-reviewed journals.Trial registration numberClinicalTrials.gov Registry (NCT04045093); pre-results.
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Chee, Yuet Yee, Rosanna Ming Sum Wong, Mabel Siu Chun Wong, Winnie Wan Yee Tso, Wilfred Hing Sang Wong, and So Lun Lee. "Changes in Mortality and Cerebral Palsy in Extremely Low-Birth-Weight Infants in a Tertiary Center in Hong Kong." Global Pediatric Health 7 (January 2020): 2333794X2090193. http://dx.doi.org/10.1177/2333794x20901932.
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Introduction. We retrospectively reviewed a cohort of extremely low-birth-weight (ELBW) babies born at Queen Mary Hospital and explored if there is any time trend in survival and short-term neurodevelopmental outcomes. Methods. We included ELBW infants born at Queen Mary Hospital between 2008 and 2015. The relationships between multiple risk factors with survival and neurodevelopmental outcomes were analyzed by either Cox regression or univariate logistic regression analysis. We also compared this birth-year period with our previous study from 1993 to 2002. Results. Two hundred seventeen ELBW infants were delivered during the study period. There was significantly higher overall survival rate (81.1%) in 2008 to 2015 compared with 71.4% in 1993 to 2002. One hundred forty-three out of 176 (81%) survivors were assessed at a corrected mean age of 18.1 months. A total of 4.2% had cerebral palsy. There were significantly lower rates of cerebral palsy in 2008 to 2015 (4.2%) compared with 1993 to 2002 (13.5%). Conclusions. We showed a temporal improvement in survival and short-term neurodevelopmental outcomes.
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Wong, W. K., Y. L. Kwok, K. Chan, and C. Y. Yeung. "An Investigation of Physical Functional Design on Child Patients’ Garment." Research Journal of Textile and Apparel 3, no. 2 (May 1, 1999): 34–40. http://dx.doi.org/10.1108/rjta-03-02-1999-b005.
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This paper investigates the design requirements for physical function on developing child patients’ garment. The requirements of style design for physical functions were collected from two questionnaire surveys through personal interviews with child patients and medical staff in the Queen Mary Hospital, the teaching hospital of the University of Hong Kong. Chisquare tests were adopted to test for associations between the responses and a range of variables. The style specifications include styles design for different age groups, sexes, medical needs, design details for top and bottom garment, selection of fasteners and accessories. The results generated ideas for the design of child patients' garment based on their physical needs during hospitalization.
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Ling, Julia, P. Y. Chau, and B. Rowe. "Salmonella serotypes and incidence of multiply-resistant salmonellae isolated from diarrhoeal patients in Hong Kong from 1973–82." Epidemiology and Infection 99, no. 2 (October 1987): 295–306. http://dx.doi.org/10.1017/s0950268800067777.
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SUMMARYSalmonella was the most frequent bacterial pathogen isolated from patients with acute diarrhoea in Hong Kong. In Queen Mary Hospital, the major hospital on Hong Kong Island, 94·7% of salmonellae isolated from faecal specimens from patients during the period 1973–82 belonged to the gastroenteric group, while 5·3% belonged to the enteric fever group. Amongst the gastroenteric group, 68 salmonella serotypes were identified, with Salmonella derby, S. typhimurium and S. analum being the predominant ones. Three outbreaks caused by S. johannesburg, S. worthington and S. wandsworth were detected.Of S. typhimurium, 61·0% were resistant to multiple antibiotics and belonged to four major phage types: 193, 22, 138 and U288. The majority (96·8%) of S. johannesburg strains which caused a widespread epidemic were multiply-resistant. Multiple antibiotic resistance was rarely observed in most other gastroenteric salmonellae.S. typhi was the commonest of the enteric fever group isolated from the blood of patients. Nineteen phage types were identified; E1 being the commonest (18·5%) while 21% were nontypable. Many of these isolated were resistant to streptomycin or sulphadiazine, but none were resistant to ampicillin, chloramphenicol or trimethoprim.
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Luk, Che-Chung. "An introduction to the Journal of Thoracic Disease focused issue “Hong Kong Queen Mary Hospital Second Thoracic Surgery Symposium”." Journal of Thoracic Disease 10, S16 (June 2018): S1841—S1842. http://dx.doi.org/10.21037/jtd.2018.04.105.
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Ko, Jennifer K. Y., and Vincent Y. T. Cheung. "A 12-year experience of the management and outcome of heterotopic pregnancy at Queen Mary Hospital, Hong Kong, China." International Journal of Gynecology & Obstetrics 119, no. 2 (August 11, 2012): 194–95. http://dx.doi.org/10.1016/j.ijgo.2012.06.006.
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Teo, Kay-Cheong, William C. Y. Leung, Yuen-Kwun Wong, Roxanna K. C. Liu, Anna H. Y. Chan, Olivia M. Y. Choi, Wing-Man Kwok, et al. "Delays in Stroke Onset to Hospital Arrival Time During COVID-19." Stroke 51, no. 7 (July 2020): 2228–31. http://dx.doi.org/10.1161/strokeaha.120.030105.
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Background and Purpose: The current coronavirus disease 2019 (COVID-19) pandemic represents a global public health crisis, disrupting emergency healthcare services. We determined whether COVID-19 has resulted in delays in stroke presentation and affected the delivery of acute stroke services in a comprehensive stroke center in Hong Kong. Methods: We retrospectively reviewed all patients with transient ischemic attack and stroke admitted via the acute stroke pathway of Queen Mary Hospital, Hong Kong, during the first 60 days since the first diagnosed COVID-19 case in Hong Kong (COVID-19: January 23, 2020–March 24, 2020). We compared the stroke onset to hospital arrival (onset-to-door) time and timings of inpatient stroke pathways with patients admitted during the same period in 2019 (pre–COVID-19: January 23, 2019–March 24, 2019). Results: Seventy-three patients in COVID-19 were compared with 89 patients in pre–COVID-19. There were no significant differences in age, sex, vascular risk factors, nor stroke severity between the 2 groups ( P >0.05). The median stroke onset-to-door time was ≈1-hour longer in COVID-19 compared with pre–COVID-19 (154 versus 95 minutes, P =0.12), and the proportion of individuals with onset-to-door time within 4.5 hours was significantly lower (55% versus 72%, P =0.024). Significantly fewer cases of transient ischemic attack presented to the hospital during COVID-19 (4% versus 16%, P =0.016), despite no increase in referrals to the transient ischemic attack clinic. Inpatient stroke pathways and treatment time metrics nevertheless did not differ between the 2 groups ( P >0.05 for all comparisons). Conclusions: During the early containment phase of COVID-19, we noted a prolongation in stroke onset to hospital arrival time and a significant reduction in individuals arriving at the hospital within 4.5 hours and presenting with transient ischemic attack. Public education about stroke should continue to be reinforced during the COVID-19 pandemic.
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Yee-Hang, Wong Birgitta, Hui Theresa, Lee So-lun, Ho Wai-Kuen, and Wei William Ignace. "Stridor in Asian Infants: Assessment and Treatment." ISRN Otolaryngology 2012 (February 19, 2012): 1–4. http://dx.doi.org/10.5402/2012/915910.
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Stridor is the main symptom of upper airway obstruction in infants. It can be congenital or acquired, acute or chronic. Pathologies can be located from the nose down to the trachea. Common causes include laryngomalacia, vocal cord palsy, subglottic stenosis, tracheal anomaly, laryngeal cleft, vascular and lymphatic malformation, laryngeal papillomas, craniofacial abnormalities and even head and neck tumours. In this paper, we will discuss our approach to infants with stridor including assessment with flexible and rigid endoscopy and treatments to various conditions in a tertiary centre. Causes of stridor in infants undergoing rigid laryngotracheobronchoscopy in Queen Mary Hospital, University of Hong Kong Medical Centre between 2005 and 2011 will be retrospectively reviewed. Treatments according to various conditions will be discussed. Successful management of these neonates requires accurate diagnosis, early intervention, and multidisciplinary care by ENT surgeons, paediatricians, and paediatric anaesthetists.
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Ling, Julia, and P. Y. Chau. "Incidence of plasmids in multiply-resistant salmonella isolates from diarrhoeal patients in Hong Kong from 1973–82." Epidemiology and Infection 99, no. 2 (October 1987): 307–21. http://dx.doi.org/10.1017/s0950268800067789.
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SUMMARYPlasmids present in multiply-resistant salmonella strains includingSalmonella typhimurium, S. johannesburg, S. wandsworth, S. derby, S. newport, S. londonandS. choleraesuiscausing diarrhoea in patients in Queen Mary Hospital in Hong Kong from 1973–82 were studied. In multiply-resistantS. typhimurium, plasmids belonging to groupsF1me, H1, or H2and plasmids encoding trimethoprim-resistance which were compatible with standard plasmids of testable incompatibility groups were detected. InS. johannesburg, both the ASTCKSu- and ASCKSu- resistant strains which were predominant in two consecutive periods of an outbreak were found to harbour the same plasmid which belonged to the incompatibility group F1me. S. wandsworthstrains isolated from a hospital outbreak in 1980 harboured an identical R-plasmid belonging to group N. A few strains of the other salmonellae showing resistance to multiple antibiotics were found to harbour R-plasmids belonging to groups H1, H2and F1me. The only salmonella of the enteric fever group resistant to ampicillin, chloramphenicol and trimethoprim was anS. paratyphi Bstrain. The resistances were encoded on a plasmid of an unknown incompatibility group. The occurrence and distribution of plasmids in these salmonellae isolated within the 10-year period are discussed.
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Ng, Alex Lap-Ki, Kelvin Kai-Wang To, Chile Chi-Lai Choi, Leonard Hsu Yuen, Suk-Ming Yim, Keith Shun-Kit Chan, Jimmy Shiu-Ming Lai, and Ian Yat-Hin Wong. "Predisposing Factors, Microbial Characteristics, and Clinical Outcome of Microbial Keratitis in a Tertiary Centre in Hong Kong: A 10-Year Experience." Journal of Ophthalmology 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/769436.
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Purpose.To study the risk factors, microbial profile, antibiotic susceptibility pattern, and outcome for microbial keratitis over the past 10 years in a tertiary center in Hong Kong.Methods.All cases with corneal scraping performed in Queen Mary Hospital, Hong Kong from January 2004 to December 2013 were included. Clinical outcome was defined as poor if the final visual acuity (VA) was abnormal or worse than presenting VA, a major complication occurred, or therapeutic keratoplasty was required.Results.347 scrapes were performed in the 10-year period growing 130 microorganisms (32.3% culture positive rate). Contact lens use was the commonest risk factor. The commonest isolates were coagulase-negativeStaphylococcusandPseudomonas aeruginosa.Fluoroquinolone susceptibility was tested in 47 Gram-negative bacteria with 93.6% susceptibility (100% forPseudomonas).90.7% of cases had good visual outcome. Multivariate logistic regression showed age (p=0.03), trauma (p=0.006), and ulcer size >3 mm (p=0.039) to be independently associated with poor outcome.Conclusion. There was no shifting trend in the isolate distribution or emergence of resistant strains in our study. Contact lens wear was the commonest risk factor, withPseudomonasbeing the most frequent isolate in this group. It remained 100% susceptible to fluoroquinolones and 97% cases had good visual outcome.
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Ho, Margaret Kay, Crystal Cheuk Yiu Hsue, Cheng Heng Nicholas Lai, Kwun Ting Chan, Cheuk Nam Cheng, Chun Fung Chow, Ka Ho Lui, et al. "A cross-sectional study on the attitudes and perceptions of outpatients towards palliative care at the Hong Kong Queen Mary Hospital Hospice Centre." Annals of Palliative Medicine 9, no. 6 (November 2020): 4522–32. http://dx.doi.org/10.21037/apm.2019.10.06.
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Yu, Stephanie Wing Yin, Andre Ma, Vivian Hiu Man Tsang, Lulu Suet Wing Chung, Siu-Chung Leung, and Ling-Pong Leung. "Triage accuracy of online symptom checkers for Accident and Emergency Department patients." Hong Kong Journal of Emergency Medicine 27, no. 4 (April 16, 2019): 217–22. http://dx.doi.org/10.1177/1024907919842486.
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Background: Overutilisation of the Accident and Emergency Department is an increasingly serious healthcare challenge. Online symptom checkers could help alleviate this challenge by allowing patients to self-triage before visiting the Accident and Emergency Department. Objectives: This study aimed to assess the triage accuracy of online symptom checkers, which would help determine the potential roles of symptom checkers in an Accident and Emergency Department setting. Methods: A total of 100 random Accident and Emergency Department records were sampled from the Queen Mary Hospital in Hong Kong. The inclusion criteria were patients over the age of 18 attending the Queen Mary Hospital Accident and Emergency Department in 2016. Symptom checkers by Drugs.com and FamilyDoctor were selected as representative tools. One triage recommendation was generated by each symptom checker for each case record. Each symptom checker’s triage accuracy was then evaluated using a few outcome measures: overall sensitivity, sensitivity for emergency cases and specificity for non-emergency cases, when compared with the triage categories assigned by the triage nurses. Results: The results showed that Drugs.com had a higher overall triage accuracy than FamilyDoctor (74% and 50%, respectively), but both checkers are inadequately sensitive to emergency cases (70% and 45%, respectively) with low negative predictive values (43% and 24%, respectively). Conclusion: In their current states, symptom checkers are not yet suitable as alternatives to Accident and Emergency Department triage protocols due to their low overall sensitivities and negative predictive values. However, symptom checkers might serve as useful Accident and Emergency Department adjuncts in other ways, such as to provide more information prior to a patient’s arrival to streamline the triage and preparation process at the Accident and Emergency Department.
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Cheung, A. N. Y., H. Y. S. Ngan, D. Cheng, R. J. Collins, E. Gwi, L. C. Wong, and H. K. Ma. "Clinicopathologic study of 16 cases of primary tubal malignancy." International Journal of Gynecologic Cancer 4, no. 2 (1994): 111–18. http://dx.doi.org/10.1046/j.1525-1438.1994.04020111.x.
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Sixteen cases of primary carcinoma of the fallopian tube were diagnosed and treated at Queen Mary Hospital, Hong Kong from July 1972 to June 1992 constituting 0.26% of the total gynecologic malignancies seen during that period. The average age was 61 years and the most common presenting symptom was abnormal vaginal bleeding. Preoperative diagnosis is difficult; in only one case was a diagnosis of malignancy made by cervical smear. An adnexal mass was detected in 13 of the cases (81.3%) either by clinical examination and/or ultrasonography. Therapy consisted of surgical resection, usually followed by various combinations of adjuvant radiation therapy and chemotherapy. The cumulative survival was 62%. In addition to the typical form of adenocarcinoma, one case of squamous cell carcinoma and a case of multifocal endometrioid adenocarcinoma were observed. One case of an apparently usual form of adenocarcinoma recurred as a heterologous malignant mixed Müllerian tumor 2 years after diagnosis. This series further emphasises the wide range of differentiation possible in the Müllerian system and the variety of neoplasms which may arise from it.
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Yu, Ruby, Jean Woo, Ruth Chan, Aprille Sham, Suzanne Ho, Annette Tso, Bernard Cheung, Tai Hing Lam, and Karen Lam. "Relationship between dietary intake and the development of type 2 diabetes in a Chinese population: the Hong Kong Dietary Survey." Public Health Nutrition 14, no. 7 (April 5, 2011): 1133–41. http://dx.doi.org/10.1017/s136898001100053x.
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AbstractObjectiveTo study the relationship between dietary intake and the development of type 2 diabetes among Chinese adults.DesignA prospective cohort study. Dietary assessment was carried out using a validated FFQ. Principal component analysis was used to identify dietary patterns. Dietary glycaemic load and variety of snacks were also calculated.SettingA hospital-based centre at the Queen Mary Hospital in Hong Kong SAR, China.SubjectsA total of 1010 Chinese adults aged 25–74 years who participated in a territory-wide dietary and cardiovascular risk factor prevalence survey in 1995–1996 were followed up for 9–14 years for the development of diabetes.ResultsA total of 690 (68·3 %) individuals completed follow-up during 2005–2008 and seventy-four cases of diabetes were identified over the follow-up period. Four dietary patterns were identified (‘more snacks and drinks’, ‘more vegetables, fruits and fish’, ‘more meat and milk products’ and ‘more refined grains’). After adjustment for age, sex, BMI, waist-to-hip ratio, smoking, alcohol intake, participation in exercise/sports and family history of diabetes, the more vegetables, fruits and fish pattern was associated with a 14 % lower risk (OR per 1 sd increase in score = 0·76; 95 % CI 0·58, 0·99), whereas the more meat and milk products pattern was associated with a 39 % greater risk of diabetes (OR per 1 sd increase in score = 1·39; 95 % CI 1·04, 1·84). Dietary glycaemic load, rice intake, snack intake and variety of snacks were not independently associated with diabetes.ConclusionsThe more vegetables, fruits and fish pattern was associated with reduced risk and the more meat and milk products pattern was associated with an increased risk of diabetes.
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Chan, Wing-Lok, Matthew Ho-Fai Cheng, Jacky Tsun-Kit Wu, Cheuk-Wai Choi, Rosa Piu-Ying Tse, Patty Piu-Ying Ho, Emina Edith Cheung, et al. "Treatment Outcomes of Computer Tomography-Guided Brachytherapy in Cervical Cancer in Hong Kong: A Retrospective Review." Cancers 14, no. 16 (August 15, 2022): 3934. http://dx.doi.org/10.3390/cancers14163934.
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(1) Background: To report the long-term clinical outcomes of computer-tomography (CT)-guided brachytherapy (BT) for locally advanced cervical cancer. (2) Methods: A total of 135 patients with FIGO stage IB-IVA cervical cancer treated with definitive radiotherapy +/− chemotherapy with an IGABT boost at Queen Mary Hospital, Hong Kong, between November 2013 and December 2019 were included. Treatment included pelvic radiotherapy 40 Gy/20 Fr/4 weeks +/− chemotherapy then CT-guided BT (7 Gy × 4 Fr) and a sequential parametrial boost. The primary outcome was local control. Secondary outcomes were pelvic control, distant metastasis-free survival, overall survival (OS) and late toxicities. (3) Results: The median follow-up was 53.6 months (3.0–99.6 months). The five-year local control, pelvic control, distant metastasis-free survival and OS rates were 90.7%, 84.3%, 80.0% and 87.2%, respectively. The incidence of G3/4 long-term toxicities was 6.7%, including proctitis (2.2%), radiation cystitis (1.5%), bowel perforation (0.7%), ureteric stricture (0.7%) and vaginal stenosis and fistula (0.7%). Patients with adenocarcinomas had worse local control (HR 5.82, 95% CI 1.84–18.34, p = 0.003), pelvic control (HR 4.41, 95% CI 1.83–10.60, p = 0.001), distant metastasis-free survival (HR 2.83, 95% CI 1.17–6.84, p = 0.021) and OS (HR 4.38, 95% CI: 1.52–12.67, p = 0.003) rates. Distant metastasis-free survival was associated with HR-CTV volume ≥ 30 cm3 (HR 3.44, 95% CI 1.18–9.42, p = 0.025) and the presence of pelvic lymph node (HR 3.44, 95% CI 1.18–9.42, p = 0.025). OS was better in patients with concurrent chemotherapy (HR 4.33, 95% CI: 1.40–13.33, p = 0.011). (4) Conclusions: CT-guided BT for cervical cancer achieved excellent long-term local control and OS. Adenocarcinoma was associated with worse clinical outcomes. (4) Conclusion: CT-guided BT for cervical cancer achieved excellent long-term local control and OS. Adenocarcinoma was associated with worse clinical outcomes.
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Yau, Thomas Cheung, Vikki Tang, Roland Ching-Yu Leung, Gin Wai Kwok, Joanne Wing-Yan Chiu, and Tan To Cheung. "Efficacy and tolerability of sorafenib in unresectable/advanced hepatocellular carcinoma patients: Real-life experience in a Hong Kong tertiary liver cancer institute." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 382. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.382.
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382 Background: To evaluate the pattern and outcomes of sorafenib use in unresectable/advanced HCC in a real life setting in a tertiary Hong Kong liver cancer centre. Methods: A retrospective review of unresectable or advanced HCC patients treated with sorafenib at Queen Mary Hospital, Hong Kong from 2010-2015 was conducted. The objectives were to evaluate the sorafenib efficacy in overall treated population as well as different subgroups; and also reviewed the tolerability of sorafenib, especially its impact on liver function. Results: During the study period, 504 consecutive cases were identified and 493 cases with sufficient clinical data were analyzed. Consistent with Asia-Pacific etiologies, 79.3% patients had chronic hepatitis B. Sorafenib was mainly used in patients with high tumor burden (75.1% BCLC-C, 68.6% MVI or/and EHS). Two-third patients (68.2%) were pretreated, mostly with loco-regional therapies . While 70.2% patients had good baseline PS 0, one-quarter (26.6%) had Child-Pugh B/C cirrhosis state. The overall survival (OS) was 8.15 months, with no difference between HBV and non-HBV subgroups. Patients had Child-Pugh A(CP-A) had significantly better OS compared with those at CP-B/C (11.1m vs 3.29m vs 3.34m). About 36.1% patients received subsequent therapies. Safety profile was essentially consistent with literature with hand-foot-skin reaction (HFSR) being the most common AE (30.7% all-grade). Interestingly, the onset of HFSR was associated with significantly better OS (median: 14.59 vs 5.59 months, p <0.001). Notably, there was no significant change in the on-treatment levels of liver function in terms of bilirubin and plasma albumin level. Conclusions: Our study confirms the efficacy and safety in using sorafenib to treat unresectable or advanced HCC patients in the real life setting. Our results are s comparable with those reported in literature. In addition, we found that 1) similar efficacy in treating HCC regardless of HBV status, 2) positive association of OS with HFSR onset, and 3) no compromised liver function during sorafenib therapy.
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Chiang, Chi Leung, Ching Lung Cheung, James Philip Hingley, Chor Wing Sing, Ka Shun Fong, Tai Chung Lam, Victor Ho-Fun Lee, et al. "Excessive mortality in 1,353 five-year survivors of nasopharyngeal cancer." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e24090-e24090. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e24090.
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e24090 Background: Survival of NPC patients has improved in past decades. Yet, survivors continue to face elevated risks of life-threatening late effects. Their impact on late mortality remains poorly quantified. Methods: 1353 five-year NPC survivors diagnosed between 1997 and 2013 at Queen Mary Hospital were reviewed. Their demographics and treatment data were taken from electronic medical records. Survival probability, standardized mortality ratios (SMRs) and absolute excessive risk were calculated for overall and cause-specific deaths. Results: At median follow-up time of 12.4 years, 412 (30.5%) five-year survivors had died at the time of analysis. 66.2% of deaths attributed to non-recurrence death. Estimated 10-, 15-, and 20-year survival probability were 81.4%, 67.6%, and 57.3% respectively. Compared to Hong Kong general population, absolute excessive risk of death from any causes was 17 deaths per 1000 person-years; overall SMR was 3.52 (95% CI: 3.19 to 3.87, p<0.001). Increases in cause-specific mortality were seen for death due to pulmonary (SMR: 6.75; 95% CI: 5.67 to 7.98) and secondary malignancy (SMR: 1.41; 95% CI: 1.06 to 1.83). Conclusions: Five-year NPC survivors still face excessive mortality long after diagnosis, and majority of death was from non-recurrence death. Further analyses are needed to determine predictive factors of excessive mortality. [Table: see text]
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Chiang, Alan Kwok Shing, Godfrey Chi Fung Chan, Shau Yin Ha, and Kwok Hung Chan. "Respiratory Syncytial Virus (RSV) Infections in Immunocompromized Children." Blood 104, no. 11 (November 16, 2004): 5300. http://dx.doi.org/10.1182/blood.v104.11.5300.5300.
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Abstract Eleven children who were immunocompromized due to chemotherapy were infected with respiratory syncytial virus (RSV) during an outbreak of RSV infection in the Pediatric Oncology Unit of Queen Mary Hospital, The University of Hong Kong. The clinical symptoms, effect on treatment regimen, outcome of infection and viral clearance had been followed prospectively in all 11 children. Viral clearance was documented by immunofluorescence and PCR studies of nasopharyngeal aspirates or nasal/throat swabs. Eight of the 11 children had upper respiratory symptoms with the remaining 3 patients progressing to lower respiratory tract infections (LRTI). All except one had protracted viral symptoms but eventually recovered without the need for specific anti-viral treatment or intensive support. However, the chemotherapy regimen or scheduled BMT had been significantly interrupted. One patient developed progressively severe pneumonia which was further complicated by adenovirus reactivation causing bone marrow failure and severe sepsis resulting in death of this patient. The viral clearance of RSV was delayed in all patients with median of 20 days (range 9–81 days). One patient had recurrence of RSV detected by PCR 35 days after intial documentation of clearance, after a BMT procedure. The delayed viral clearance correlated with protracted viral symptoms. In conclusion, RSV clearance is delayed in immunocompromized hosts causing protracted viral symptoms, progression to LRTI and interruption to chemotherapy treatment. The delay in viral clearance appears proportional to the degree of immunosuppression of the individual.
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Yau, Thomas Cheung, Vikki Tang, Jess Chan, Gin Wai Kwok, Joanne Chiu, Roland Ching-Yu Leung, Bryan Li, and Tan To Cheung. "Outcomes of tyrosine kinase inhibitors (TKI) after immunotherapy in unresectable or advanced hepatocellular carcinoma (HCC) patients." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 361. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.361.
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361 Background: The outcomes of tyrosine kinase inhibitor(TKI) treatment after immune checkpoint inhibitors (PD-1i, PD-L1i, CTLA-4i) in unresectable/advanced HCC population is largely unknown. Methods: Retrospective analysis of advanced HCC patients treated with immune checkpoint inhibitors followed by TKI therapy at Queen Mary Hospital, Hong Kong were reviewed for the outcomes. Patients received locoregional therapy immediately after immunotherapy were excluded. Results: From January 2016 to July 2018, 30 HCC patients (83% of HBV, 80% of Child Pugh A, 83% of EHS/ MVI, median AFP=1,353ng/mL) who received TKI (11 lenvatinib, 10 sorafenib, 6 regorafenib, 3 axitinib) after immunotherapy were identified. TKI post-immunotherapy ("index TKI") was administered as third-line or beyond in 70% of patients. At the time of analysis (September 2018), median duration of index TKI was 72 days (IQR 36- 119∗) (∗3 patients were still receiving TKI). AFP declined in 53% of patients and the median change from baseline to nadir was -25% (IQR -65% to +6%). 40% of patients received subsequent systemic therapy. Median OS from index TKI was 602 days (95%CI 124-not reached; death event rate: 47%). 3 patients achieved partial response to TKI and they had at least stable disease with the previous immunotherapy. No unexpected safety issues of TKI and death related to adverse events were noted (table). Conclusions: TKI is active with good tolerabilty following immunotherapy in advanced HCC patients.[Table: see text]
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Lo, Regina Cheuk-lam, Kristy Kwan-shuen Chan, Kenneth Siu-ho Chok, and Irene Oi-lin Ng. "Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre." Journal of Clinical Pathology 71, no. 1 (July 27, 2017): 72–78. http://dx.doi.org/10.1136/jclinpath-2017-204334.
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AimsLiver allograft biopsy is important in the management of liver transplant (LT) recipients. Cholestasis is an indicator of liver dysfunction, and histological evidence of cholestasis can be observed in a wide range of pathological entities in the post-LT setting. In this study, we describe the clinicopathological features and significance of liver allograft biopsies with histological cholestasis over 11 years in our centre.MethodsLiver allograft biopsies performed in Queen Mary Hospital, Hong Kong from 2004 to 2014 showing histological cholestasis were retrieved from the pathology archive. Clinical and pathological data were retrospectively reviewed and analyzed.ResultsAmong the 254 biopsies from 167 patients, large duct obstruction (LDO) and acute cellular rejection (ACR) were the two main aetiologies associated with cholestasis. There was a decrease in sepsis as a cause over the study duration. In cases showing cholestasis at 6 months or more after LT, LDO was more common than ACR. Over half (61%) of the 254 biopsies showed mild cholestasis. Severe panacinar cholestasis was more often observed in LDO. Mild cholestasis was most commonly observed regardless of the severity of ACR. Severe cholestasis was associated with poorer 1-year and 3-year graft survival and patient survival, as well as higher 3-month and 6-month post-biopsy mortality.ConclusionHistological cholestasis and its severity in liver allograft biopsies has clinical and prognostic significance. Our study summarizes our previous experience and provides further insights into the management of post-LT patients.
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Yau, T., P. Chan, J. Tsang, R. Liang, and R. Epstein. "XELOX causes less disabling peripheral neuropathy than FOLFOX 4 for Chinese colorectal cancer patients." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 14592. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14592.
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14592 Background: Infusional 5-FU plus leucovorin and oxaliplatin (FOLFOX4) is an efficacious treatment for colorectal cancer patients in both the adjuvant and metastatic settings. However, around 10% of FOLFOX4 patients will develop with disabling grade 3–4 neuropathy. Recent phase II studies have demonstrated that oral capecitabine in combination with oxaliplatin (XELOX) is as least as effective as FOLFOX4 for colorectal cancer. In this study, we assessed the toxicities of XELOX in Chinese colorectal cancer patients. Methods: Patients who received XELOX at Queen Mary Hospital, Hong Kong between November 2004 and November, 2006 were analyzed. Toxicities were graded by the National Cancer Institute common toxicity system. Results: Thirty-five patients received XELOX on an outpatient basis during the study period: Twenty-four as adjuvant therapy and 11 as treatment for metastatic disease. The most common side effect was grade 1–2 peripheral neuropathy which occurred in 77% of patients. No grade 3–4 neuropathy was reported. Grade 1–2 diarrhea and palmar-plantar erythrodysesthesia (PPE) also occurred in 40 % and 37 % of patients, respectively. The commonest grade 3 toxicities was diarrhea which occurred in 17% of the patients followed by 9% of patients experienced grade 3 PPE. No grade 4 toxicities were reported in our patient’s cohort. Overall, only one (3%) patient had neutropenic sepsis and 36% of patients required 20% reduction in drug dosage. No treatment related death was reported. Conclusions: Our study suggests that XELOX is a well-tolerated and convenient treatment regime. Although mild neuropathy is common in patients receiving XELOX, it causes far less disabling neuropathy than FOLFOX4 in Chinese metastatic colorectal cancer patients. No significant financial relationships to disclose.
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Chan, Wing-Lok, Horace Cheuk-Wai Choi, Brian Lang, Kai-Pun Wong, Kwok-Keung Yuen, Ka-On Lam, Victor Ho-Fun Lee, and Dora Kwong. "Health-Related Quality of Life in Asian Differentiated Thyroid Cancer Survivors." Cancer Control 28 (January 1, 2021): 107327482110297. http://dx.doi.org/10.1177/10732748211029726.
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Background: Health-related quality of life (HRQoL) is important for differentiated thyroid cancer survivors, but data for Asian survivors is lacking. This study aimed to have an overview of, and identify any disease-or treatment-related factors associated with, HRQoL in Asian differentiated thyroid cancer survivors. Patients and Methods: Thyroid cancer survivors were recruited from the thyroid clinics at Queen Mary Hospital, Hong Kong from February 2016 to December 2016. All adult differentiated thyroid cancer patients with stable disease more than or equal to 1 year received a survey on HRQoL using the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Thyroid cancer specific quality of life (THYCA-QoL) questionnaire. Clinical information was collected retrospectively from the computerized clinical management system. To identify factors associated with poor HRQoL, univariable and stepwise multivariable regression analysis were performed. Results: A total of 613 survivors completed the questionnaires (response rate: 82.1%; female: 80.1%; median survivorship: 7.4 years (range: 1.0-48.2 years)). The QLQ-C30 summary score mean was 84.4 (standard deviation (SD): 12.7) while the THYCA-QoL summary score mean was 39.9 (SD: 9.7). The 2 highest symptom subscales were fatigue (mean: 26.4, SD: 20.6) and insomnia (mean: 26.2, SD: 27.6). Factors associated with worse HRQoL included serum thyrotropin (TSH) greater than 1.0 mIU/L, unemployment, and concomitant psychiatric disorders. Concomitant psychiatric illness (n = 40/613, 6.5%) also showed significant association with most of the symptom and functional subscales. Conclusions: Fatigue and insomnia were the 2 most common symptoms experienced by our differentiated thyroid cancer survivors. Long-term survivorship care with monitoring serum TSH level, supporting return-to-work and screening for concomitant psychiatric disorders should be offered.
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Wong, Hai Ming, Chun Hung Chu, and Godfrey Chi Fung Chan. "Oral health-related quality of life among children undergoing cancer therapy." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e12006-e12006. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e12006.
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e12006 Background: Despite much interest in oral complications in cancer patients and studies reporting their prevalence, aetiology and management, there has been little understanding of how they affect the patients and the family. The aim of this study was, therefore, to assess the impact of oral complications on life quality for children undergoing cancer therapy. Methods: Seventy 6 - 14 years old paediatric patients undergoing cancer therapy in the Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, Hong Kong participated in this study. A clinical examination of the dentition and oral soft tissues was performed using criteria suggested by the World Health Organization. Clinical examination evaluated the status of: i) dental caries (DMFT/dmft Index), ii) periodontal health (CPI Index), iii) infection, such as herpes and candidiasis, iv) thrombocytopathy in the form of oral petechiae and spontaneous gingival bleeding, v) xerostomia, and vi) mucositis (WHO Mucositis Scale). Two questionnaires were filled by the children and their parents: i) the Child Perceptions Questionnaire (CPQ), and ii) a questionnaire contained simple closed questions to collect the information of oral health habits of children and demographic data from the parents. Results: Higher CPQ scores were found in children with mucositis (p < 0.001), dental caries (p < 0.001), children who were born in mainland China (p < 0.05), or parents of lower education or income level (p < 0.05). In multiple regression analyses, mucositis and dental caries were the significant predictors (p < 0.001) of the higher CPQ scores among the various parents and children characteristics collected in this survey. Conclusions: The findings of this study showed that paediatric cancer patients with mucositis and dental caries had poorer oral health-related quality of life.
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Hobbs, C. G. L. "Department of Head and Neck Surgery, Queen Mary Hospital, University of Hong Kong, China, and Department of Otolaryngology, Head & Neck and Skull Base Surgery, St Vincent's Hospital, University of New South Wales, Sydney, Australia, December 2008 to June 2009." Journal of Laryngology & Otology 124, no. 9 (July 6, 2010): 1037–39. http://dx.doi.org/10.1017/s0022215110001581.
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Leung, Anskar Y. H., Eric Tse, Herman S. Y. Liu, Joycelyn Sim, Bonnie C. S. Kho, Sze-Fai Yip, Harold K. K. Lee, and Yok Lam Kwong. "The Use of Clofarabine and Cytarabine Combination (CLARA) As Salvage Therapy for Relapsed and/or Refractory Acute Myeloid Leukemia (AML)." Blood 120, no. 21 (November 16, 2012): 1518. http://dx.doi.org/10.1182/blood.v120.21.1518.1518.
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Abstract Abstract 1518 Patients with relapsed and/or refractory acute myeloid leukemia (AML) have a very dismal outcome and treatments are largely unsatisfactory. Salvage therapy is often limited by drug resistance and organ toxicities in patients who have already been exposed to multiple lines of chemotherapy. Clofarabine is a second generation nucleoside analogue with multiple mechanisms of action including inhibition of ribonucleotide reductase, suppression of DNA polymerase, direct DNA incorporation and induction of apoptosis. In this study, we evaluated the clinical outcome of patients with relapsed and/or refractory AML who received combination treatment of clofarabine and cytarbine (acronym CLARA) at Queen Mary Hospital in Hong Kong. The treatment with CLARA comprised clofarabine 40 mg/m2 and cytarabine 2 gm/m2 given intravenously for five days. For patients who relapsed after allogeneic hematopoietic stem cell transplantation (HSCT), CLARA was followed by the infusion of either BM or mobilized peripheral blood stem cells (PBSC) from the original donor and immunosuppression (cyclosporine A at 1.5 mg/kg twice daily) was given from day 8 after HSC infusion. All patients received standard anti-microbial prophylaxes and G-CSF support during neutropenia. Remission status was confirmed by bone marrow examination. Since 2009, a total of 55 patients have been recruited of whom 19 received CLARA at relapse after allogeneic HSCT. The median age of the patients was 45 years (range 20–64) and cytogenetic categorizations were favorable (N=7); intermediate (N=29) and unfavorable (N=14) in 50 evaluable patients. There were a median of two regimens (range 1–4) and five courses (range 1–12) of chemotherapy before CLARA. All patients developed grade 4 hematologic toxicity and 20% (no. of patients: grade 1–2=8; grade 3= 3) and 60% (grade 1–2=23; grade 3–4=10) developed dermatologic and liver toxicities. Six patients including three who relapsed after HSCT (out of 19 patients=16%) and three non-transplant patients (out of 36 patients=8%) died of treatment related mortality after CLARA (overall 11%). Twenty-seven patients (49%) achieved complete remission (CR) or CR with insufficient hematologic recovery (CRi). Patients who received CLARA for relapse post-HSCT had a higher CR/CRi (12 out 19 patients=63%) than the non-transplant patients (15 out of 36 patients=42%). The respective median disease-free (DFS) and overall-survivals (OS) of the post-HSCT relapse and non-transplant patients were 9.6 and 5.0 months (DFS) and 11.5 and 8.0 months (OS). CLARA is an effective salvage regimen for both post-HSCT relapse and non-transplant patients with tolerable side-effects. The optimal consolidation and maintenance strategies after CLARA would have to be further defined. Acknowledgments: Clofarabine was provided by a compassionate program from Sanofi-aventis Hong Kong Ltd. Disclosures: Off Label Use: Clofarabine.
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So, Wing Hong, Ho Fai Chan, and Mei Kwan Li. "Investigation of risk factors of geriatric patients with significant brain injury from ground-level fall: A retrospective cohort study in a local Accident and Emergency Department setting." Hong Kong Journal of Emergency Medicine 25, no. 6 (May 10, 2018): 305–12. http://dx.doi.org/10.1177/1024907918775166.
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Background: Trauma was the fifth leading cause of death in Hong Kong in 2013.4 Injuries caused by falls ranked first in traumatic brain injury (TBI) cases among older adults (51%).5 Elderly trauma patients face an increased risk of adverse consequences6 from trauma compared with their younger counterparts, as advanced age itself is already a well-recognized risk factor for less favorable outcomes following trauma. Therefore, identifying factors associated with significant brain injury in geriatric patients in A&E triage is crucial in providing timely care to these patients. Objectives: To identify the risk factors for geriatric patients with significant brain injury from ground-level falls and to formulate their association of risk factors with significant brain injury as a consequence from ground-level falls. Methods: This was a retrospective study with data collected from the Clinical Data Analysis and Reporting System of Queen Mary Hospital from 1 January 2013 to 31 December 2015. A total of 1101 cases were identified. Results: There were 76% of the recruited patients with a normal computed tomography scan. However, the remaining 24% had computed tomography scans indicative of brain injury. Severe head injuries were scored 3 -8 on the Glasgow Coma Scale and moderate head injuries were scored 9 -12. Respectively, these were 20 times (p = 0.005) and 5 times (p = 0.002) more likely to have positive computed tomography findings than patients with a Glasgow Coma Scale score from 13 to 15. Patients with loss of consciousness were two times more likely to have a positive computed tomography result than those without loss of consciousness (p = 0.001). Although warfarin use is a well-established risk factor for intracranial hemorrhage after head injury, in our dataset, the result was not statistically significant. However, the use of new oral anti-coagulants was associated with positive computed tomography findings with patients taking new oral anti-coagulants 2.3 times more likely to have positive computed tomography findings compared with those with no anticoagulant use (p = 0.033). Conclusions: Early detection of patients with significant brain injury and aggressive management may prevent secondary injury from the complications of brain injury, hence improving patient mortality and morbidity, and reducing hospital stay and health care costs.
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Mallineni, Sreekanth Kumar, and Cynthia Kar Y. Yiu. "A Retrospective Audit of Dental Treatment Provided to Special Needs Patients under General Anesthesia During a Ten-Year Period." Journal of Clinical Pediatric Dentistry 42, no. 2 (January 1, 2018): 155–60. http://dx.doi.org/10.17796/1053-4628-42.2.13.
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Objective: The purpose of this study was to perform a comprehensive audit of dental treatment provided to special needs patients (SNP) under general anesthesia (GA) over a ten-year period. Study design: Special needs patients who received dental treatment under GA as an in-patient at Queen Mary Hospital, Hong Kong SAR during the time period January 2002 and December 2011 were included in the study. The study population was divided into three groups, based on age (<6years, 6–12 years, >12 years). One-way ANOVA was used to evaluate the effect of “age group” on duration of treatment, post-recovery time, treatment procedures and utilization of different restorative materials. Kappa statistics were used for intra-examiner reliability. Results: A total of 275 patients (174 males and 101 females) were included in the study. The mean age of the patients at the time they received GA was 12.37±10.18 years. Dental procedures performed were mostly restorative in nature (47%). The >12 years group had significantly shorter treatment duration (p<0.05). No significant difference in post-operative recovery time was observed among the three age groups (p>0.05). The <6 years group received significantly less preventive, but more restorative procedures (p<0.05). Significantly fewer extractions were performed in the 6–12 years group (p<0.05). The use of composite restorations was significantly higher in the <6 years group; while amalgam restorations were more frequently used in the >12 years group (P<0.05). Stainless steel crowns were more frequently employed in SNP under 12 years of age (p<0.05). Intra-examiner reliability was good (k=0.94). Conclusions: Most of the dental procedures performed under GA on SNP were restorative procedures. For children less than 6 years of age, had longer treatment time under GA. Composite restorations and stainless steel crowns were more frequently used in the primary dentition and amalgam restorations were more frequently employed in the permanent dentition.
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Ahmed, Syed Kamran, Jason Pui Yin Cheung, Boris Kwok-Keung Fung, and Wing-Yuk Ip. "LONG TERM RESULTS OF MATCHED HEMIRESECTION INTERPOSITION ARTHROPLASTY FOR DRUJ ARTHRITIS IN RHEUMATOID PATIENTS." Hand Surgery 16, no. 02 (January 2011): 119–25. http://dx.doi.org/10.1142/s0218810411005217.
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Introduction: The distal radioulnar joint (DRUJ) is commonly affected in rheumatoid arthritis and is associated with significant functional morbidity. The aim of our study is to review our results with matched hemi-resection interposition arthroplasty in patients with DRUJ arthritis. Methods: This was a retrospective study of 39 patients with 51 wrists that were treated at Queen Mary Hospital in Hong Kong from 1989 to 2007. All patients underwent matched hemi-resection interposition arthroplasty and dorsal wrist synovectomy. Long arm hinged elbow brace was used for three weeks followed by intensive rehabilitation up to twelve weeks. The indicators of outcome included range of motion assessment, pain, wrist stiffness, grip of strength and need for revision assessed during follow-up. Statistical analysis was performed with student t-test. Results: The average age of patients was 50.5 years (25 to 77 years) and there was a 35:4 female to male ratio. The average follow up was 4.5 years ranging from 1 to 18 years. Associated extensor tendon ruptures were found in 31.4% patients. The average increase in supination was from 73 degrees preoperatively to 81 degrees at long term follow up (p = 0.10 at 1 year and 0.13 at long term follow-up). The average increase in pronation was from 68 degrees preoperatively to 74 degrees on long term follow up (p = 0.57 at 1 year and 0.02 at long term follow-up). There was evidence of painless, relatively stiff but functional wrist in 37.25% of patients. There was an increase in grip strength from an average of 6.1 kilogram force preoperatively to an average of 11.5 kilogram force at follow-up (p = 0.004 at 1 year and 0.15 at long term follow-up). Complete relief of ulnar sided pain was seen in 43 wrists (84%), partial relief was seen in 7 wrists (13.7%) and no relief was found in one wrist (1.9%). Conclusions: DRUJ arthroplasty is a rewarding procedure and most of the patients obtain pain free movement.
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Chiu, Joanne Wing-Yan, Thomas Cheung Yau, Tan To Cheung, Albert Chan, Siu-Ho Chok, Wing-Chiu Dai, Roland Ching-Yu Leung, See-Ching Chan, and Chung-Mau Lo. "Use of sorafenib in recurrent hepatocellular carcinoma (HCC) after liver transplantation." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 440. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.440.
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440 Background: Sorafenib (Sor) is the only approved systemic therapy for advanced HCC yet the safety and efficacy for its use in patients (pts) who developed recurrence after liver transplantation (LT) has not been established. There is an unmet need for treatment option in this group of pts. Methods: This is a retrospective analysis of pts treated with Sor for recurrent HCC post-LT in Queen Mary Hospital, Hong Kong. Results: During year Jan 2008 to Feb 2014, 25 post-LT pts with HCC recurrence were treated with Sor. Tacrolimus and sirolimus were the immunosuppressant of choice during the same treatment period in 76% (19/25) and 40% (10/25) pts respectively. All pts had Child-Pugh A liver function and ECOG performance status 0-1. Majority of pts were chronic hepatitis B carriers (88%) and male (88%). Median time to recurrence was 13.2 months (range 3.4-71.1). Intrahepatic recurrence and extrahepatic recurrence were found in 52% and 80% of pts respectively. Up to 68% of pts received the standard dose of 800 mg/day. The most common adverse events (AEs) were hand-foot syndrome (44%) and diarrhea (28%). G3 transaminase elevation was found in 4 pts (16%), in which 2 had histological evidence of acute graft rejection. Both cases were associated with tailing down of tacrolimus upon tumor progression, and the liver function recovered after adjustment of immunosuppressant. Nine pts (36%) required dose adjustment. The median maintenance dose was 400 mg/day. The median duration of treatment was 4.44 months (95% CI 2.53-6.44). Median time to progression was 6.21 months (95% CI 2.83-9.63). Median overall survival was 13.6 months (95% CI 7.69-19.61). Ten (40%) pts also received other subsequent systemic therapy. Conclusions: Sor given in combination with tacrolimus and sirolimus did not lead to unexpected graft rejection. The drug is in general tolerated in this population and toxicities appeared to be similar to non-transplant pts. Further study is required to evaluate for drug interaction and efficacy.
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Curtin, Justin, Peter Thomson, Gordon Wong, Alfred Lam, and Siu-Wai Choi. "The Impact of Surgery on Circulating Malignant Tumour Cells in Oral Squamous Cell Carcinoma." Cancers 15, no. 3 (January 18, 2023): 584. http://dx.doi.org/10.3390/cancers15030584.
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Importance: The extent to which surgical management of oral squamous cell carcinoma (OSCC) disseminates cancer is currently unknown. Objective: To determine changes in numbers of malignant cells released into systemic circulation immediately following tumour removal and over the first seven post-operative days. Design: An observational study from March 2019 to February 2021. Setting: This study was undertaken at Queen Mary University Hospital, Hong Kong. Participants: Patients with biopsy-proven oral SCC were considered for eligibility. Patients under 18 years of age, pregnant or lactating women and those unable to understand the study details or unable to sign the consent form were excluded. Twenty-two patients were enrolled (12 male and 10 female) with mean age of 65.5 years. Intervention: Primary tumour management was performed in accord with multi-disciplinary team agreement. Anaesthesia and post-operative care were unaltered and provided in accord with accepted clinical practice. Main Outcomes and Measures: Three types of malignant cells detected in peripheral blood samples were enumerated and sub-typed based on the presence of chromosomal aneuploidy and immunohistochemical characteristics. To test the hypothesis that malignant cells are released by surgery, the numbers of single circulating tumour cells (CTCs), circulating tumour microemboli (CTM) and circulating endothelial cells (CTECs) were recorded pre-operatively, upon tumour removal and the second and seventh post-operative days. Results: Of a potential 88 data collection points, specimens were not obtainable in 12 instances. Tumour removal resulted in a statistically significant increase in CTCs and a non-statistically significant rise in CTMs. CTCs, CTMs and CTECs were detected in the majority of patients up to the seventh post-operative day. Individual patients demonstrated striking increases in post-operative CTCs and CTECs numbers. Conclusions/Relevance: Surgical management of OSCC has a significant impact on the systemic distribution of cancer cells. Malignant cells persisted post-operatively in a manner independent of recognised staging methods suggesting differences in tumour biology between individuals. Further investigation is warranted to determine whether circulating malignant cell enumeration can be used to refine risk stratification for patients with OSCC.
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Au, Wing-Yan, Sidney Tam, Anskar Y. H. Leung, Eric Tse, Cyrus Kumana, and Yok Lam Kwong. "Oral Arsenic Trioxide without Chemotherapy as Maintenance Therapy for Patients with Acute Promyelocytic Leukemia in First Complete Remssion." Blood 112, no. 11 (November 16, 2008): 2959. http://dx.doi.org/10.1182/blood.v112.11.2959.2959.
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Abstract ORAL arsenic TRIOXIDE without chemotherapy as MAINTENANCE THErAPY for patients with Acute promyelocytic leukemia in first complete remssion Wing-Yan Au, Sidney Tam, Anskar Y.H. Leung, Eric Tse, Cyrus Kumana, Yok-Lam Kwong. Departments of Medicine and Clinical Biochemistry, Queen Mary Hospital, Hong Kong Background. Conventional maintenance therapy for acute promyelocytic leukemia (APL) in first complete remission (CR1) comprises all-trans retinoic acid (ATRA), mercaptopurine and methotrexate. Arsenic trioxide (As2O3) is used predominantly in relapsed cases. The efficacy and safety of earlier use of As2O3 in maintenance remain undefined. The availability of oral-As2O3 makes As2O3 maintenance practical. Materials and methods. From 2001–2008, 49 patients (24 men, 25 women, median age: 44 (16–73) years) with APL in CR1 (achieved after induction with ATRA, daunorubicin and cytosine arabinoside, and consolidated with daunorubicin and cytosine arabinoside) were studied. The following 2-year oral-As2O3 maintenance regimens were used: oral- As2O3 (10 mg/day × 14 Tevery 2 months, n=20), oral-As2O3 + ATRA (22.5–45 mg/m2/day × 14 every 2 months, n=20), and oral-As2O3 + ATRA + ascorbic acid (1 gm/day × 14, every 2 months, n=9). As2O3 regimens were approved by the institutional review board at Queen Mary Hospital. All As2O3 maintenance regimens were orally administered at home. Results. At diagnosis, the presenting leucocyte count was > 10 × 109/L in 9 cases, and platelet count < 40 × 109/L in 32 cases. At a median follow-up of 25 (2–87) months, there were 4 relapses (risk group: high, n=3; low, n=1; relapse site: bone marrow, n=4; central nervous system, CNS, n=2; maintenance protocol: As2O3, n=2, As2O3+ATRA, n=2). CR2 was achieved in all patients with further As2O3-based therapy, although 2 patients ultimately relapsed again and died of refractory leukemia. Of the 45 patients in continuous CR1, 3 patients had died of unrelated causes (stroke at 62 months, nasopharyngeal carcinoma at 24 months, carcinoma of colon at 86 months). Three other solid tumors (carcinoma of colon, n=2; salivary gland cancer, n=1) were diagnosed. Of the 5 solid tumors found in this cohort, only 1 was diagnosed after commencement of As2O3-maintenance. The 3-year leukemia-free-survival and overall-survival were 89% and 77%. There was no difference in survival between patients receiving different oral-As2O3 maintenance regimens, and stratified according to risk factors. Adverse effects of the oral-As2O3 maintenance included headache (n=18), gastric discomfort (n=7), herpes zoster reactivation (n=10), reversible liver function derangement (n=12), menorrhagia (n=3), and rash (n=8). Clinical arrhythmias were not observed. There were no defaults in treatment due to side effects. Conclusion. Oral-As2O3 maintenance is a simple regimen that is well tolerated, entirely oral and administered at home. This regimen considerably reduces exposure to anthracyclines, topoisomerase II inhibitors and anti-metabolites as used in other protocols, which is potentially advantageous for a curable leukemia, in view of chemotherapyinduced long-term complications. Although >60% of our patients belonged to intermediate and high-risk groups, this regimen was comparable to other multi-chemotherapy regimens in maintaining remission.
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Nair, Anjali Ajay, Samreen Afroz, Bushra Urooj Ahmed, Uzma Urooj Ahmed, Chi Chung Foo, Hind Zaidan, and Martin Corbally. "Smartphone Usage Among Doctors in the Clinical Setting in Two Culturally Distinct Countries: Cross-sectional Comparative Study." JMIR mHealth and uHealth 9, no. 5 (May 10, 2021): e22599. http://dx.doi.org/10.2196/22599.
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Background Smartphones and mobile applications have seen a surge in popularity in recent years, a pattern that has also been reflected in the health care system. Despite increased reliance among clinicians however, limited research has been conducted on the uptake and impact of smartphone usage in medical practice, especially outside the Western world. Objective This study aimed to identify the usage of smartphones and medical apps by doctors in the clinical setting in 2 culturally distinct countries: King Hamad University Hospital (KHUH), Bahrain and Queen Mary Hospital (QMH), Hong Kong. Methods A cross-sectional, comparative study was conducted where doctors in both hospitals were asked to take part in a 15-item online survey. The questions were categorized into the following groups: demographics of the study population, ownership and main use of smartphones, number and names of medical apps currently owned, rating usage of smartphones for medical purposes, time spent on a smartphone related to clinical use, clinical reliance on smartphones, and views on further integration of smartphones. The results were then tabulated and analyzed using SPSS Statistics 25 for Mac (IBM Corp Inc, Armonk, NY). Results A total of 200 doctors were surveyed, with a total of 99.0% (99/100) of the doctors owning a smartphone in both KHUH and QMH; 58% (57/99) and 55% (54/99) of the doctors from KHUH and QMH, respectively, identified communication as their main use of smartphones in the clinical setting (P=.004). Doctors from KHUH were likely to spend more time on medical apps than doctors from QMH (P=.002). According to the overall results of both hospitals, 48% (32/67) of the junior doctors claimed high reliance on smartphones, whereas only 32.3% (41/127) of the senior doctors said the same (P=.03). Of doctors in KHUH and QMH, 78.0% (78/100) and 69.0% (69/100), respectively, either strongly agreed or agreed that smartphones need to be integrated into the clinical setting. In terms of preferences for future apps, 48% (48/100) and 56% (56/100) of the doctors in KHUH and QMH, respectively, agreed that more medical applications need to be created in order to support smartphone use in the clinical setting. Conclusions These results suggest a substantial acceptance of smartphones by doctors in the clinical setting. It also elicits the need to establish policies to officially integrate smartphone technology into health care in accordance with ethical guidelines. More emphasis should be placed on creating medical applications that aid health care professionals in attaining their information from accurate sources and also regulate a system to monitor the usage of mobile devices within hospitals to prevent a breach of patient privacy and confidentiality.
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Tse, Kai-Chung, Pok-Siu Yip, Man-Fei Lam, Fu-Keung Li, Bo-Ying Choy, Tak-Mao Chan, and Kar-Neng Lai. "Recurrent Hemoperitoneum Complicating Continuous Ambulatory Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 22, no. 4 (July 2002): 488–91. http://dx.doi.org/10.1177/089686080202200407.
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♦ Objectives To study the clinical features, clinical outcomes, and peritoneal transport characteristics of patients with recurrent hemoperitoneum complicating continuous ambulatory peritoneal dialysis (CAPD). ♦ Design Single-center retrospective case review of patients on CAPD over a 10-year period. ♦ Setting Renal Unit in Queen Mary Hospital, a tertiary-care referral center in Hong Kong. ♦ Patients 549 patients were available for review. 46 patients (8.4%) had at least one episode of hemoperitoneum during their course of CAPD; 25 patients had only one episode of hemoperitoneum and they were excluded. The remaining 21 patients (3.8%) had two or more episodes of hemoperitoneum and they were included for review. ♦ Main Outcome Measures Basic demographic factors and the etiology and episodes of hemoperitoneum were recorded. Clinical outcomes included continuation on peritoneal dialysis, conversion to hemodialysis (HD), renal transplantation, and death. The reason for conversion to HD, the causes of death, and serial peritoneal equilibration tests (PET) using dialysate-to-plasma ratio of creatinine (D/P creat) and ratio of dialysate glucose at hours 4 and zero of the dwell (D4/D0) with standard 2-L 2.5% glucose dialysate were assessed. ♦ Results There were 549 patients with total of 91 episodes of recurrent hemoperitoneum affecting 21 patients (3.8%). Mean age was 50.2 years (range 24 – 76 years) and mean duration of dialysis was 61.6 months (range 2 – 166 months). There were 14 female patients (66.7%) and 7 male patients (33.3%). The average number of hemoperitoneum episodes was 4.3 per patient (range 2 – 12). The mean time interval of the first hemoperitoneum episode from commencement of peritoneal dialysis was 10.5 months (range 1 – 37 months, SD 9.7 months). Most cases were due to retrograde menstruation in females and unknown cause in males. Two patients had intra-abdominal pathology accounting for hemoperitoneum. Thirteen patients (61.9%) continued CAPD, 2 (9.5%) underwent renal transplantation, and 2 (9.5%) were converted to long-term HD. The reason for conversion to HD was related to hemoperitoneum in 1 patient (4.8%) only. Four patients (19.0%) died; the causes of death were unrelated to hemoperitoneum. There was no correlation between recurrent hemoperitoneum and peritonitis episodes ( p = 0.18). There was no significant association between hemoperitoneum episodes and clinical outcomes ( p = 0.91) or survival ( p = 0.52). None of the patients developed ultrafiltration failure on long-term follow-up. ♦ Conclusions Recurrent hemoperitoneum is a benign complication of CAPD, with no significant long-term effects on patient survival, predisposition to peritonitis, or ultrafiltration failure.
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Szeto, Karen W. H. "New Medical Record System in Queen Elizabeth Hospital, Hong Kong." Health Information Management 24, no. 4 (December 1994): 131–34. http://dx.doi.org/10.1177/183335839402400404.
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During the 1980's, the medical record problems had been identified and it was not until 1991 that Queen Elizabeth Hospital was chosen to be the pilot hospital for the development of a new medical record management system for the Hospital Authority hospitals. The new medical records system was implemented in Queen Elizabeth Hospital in December, 1993. Six month after implementation, a pre-implementation and post-implementation review of the medical record services were conducted to compare the results of the new and old system. The results showed that there were significant improvements in the record retrieval and record integrity in the new system. New medical record services such as the delivery of readmission records to the ward, filing of medical records forms in pre-defined order and filing of loose sheets in the relevant hospital notes are able to facilitate the efficient, effective and complete access to patient information. The support and cooperation of the hospital staff are crucial to the success of the new system. Continuous review and improvement of the new system is essential in order to obtain the best results
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Zhang, Ying, John R. Murphy, and Daniel G. Wright. "Effective Delivery of Antisense Peptide Nucleic Acid Oligomers into Cells by Anthrax "Protective Antigen"." Blood 104, no. 11 (November 16, 2004): 5256. http://dx.doi.org/10.1182/blood.v104.11.5256.5256.
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Abstract A detailed understanding of the genetic basis of inherited and acquired hematologic diseases has emerged during recent decades, encouraging efforts to develop genetically targeted reagents as both experimental tools and novel therapeutics. Peptide nucleic acid (PNA), a DNA mimic in which the phosphate deoxyribose backbone of DNA has been replaced by a pseudopeptide polymer, first described in 1991, has attracted particular interest as a gene-targeting reagent, since it is highly stable and binds to complementary RNA and DNA with high affinity and specificity. However, because PNA oligomers resist cellular uptake, their development as tools for modifying gene expression in whole animal studies or as potential therapeutic agents has been limited. To explore the possibility that the transmembrane "transport" domains of microbial toxin proteins might serve as vehicles for cellular delivery of PNA, we studied the ability of recombinant Anthrax "protective antigen" (PA), the non-toxic component of Anthrax toxin that mediates cell binding and delivery, to transport antisense PNA oligomers effectively into cells. For these studies, we first generated CHO-K1 cell lines (CHO-Luc654) that had been engineered by stable transfection to express a modified luciferase gene (Luc-βIVS2-654) interrupted by a mutant β-globin intron-2 with an aberrant splice site that could be blocked by antisense PNA, thereby inducing luciferase expression as an indicator of antisense activity (ref.Sazani & Kole, J Clin Invest112:481, 2003). We then synthesized PNA oligomers with poly-lysine tails and 18-mer nucleobase sequences antisense to a region of Luc-βIVS2-654 pre-mRNA flanking the aberrant IVS2-654 splice site. As anticipated from prior reports (Nucleic Acids Res29:3965, 2001), antisense PNA-(Lys)8 oligomers demonstrated detectable sequence-specific activity in inducing luciferase expression in CHO-Luc654 cells when incubated with the cells for 48–72 hrs at micromolar concentrations. However, this activity was greatly and significantly amplified when CHO-Luc654 cells were incubated with antisense PNA-(Lys)8 together with Anthrax PA (0.3–1.0 μg/mL), which had no effects on the cells by itself, such that antisense activity could be detected at PNA concentrations as low as 30 nM. Antisense PNA-(Lys)8 (300 nM), with but not without Anthrax PA (0.3 μg/mL), was also found by rtPCR to induce correctly spliced β-globin transcripts in cultured erythroid progenitor cells obtained from a patient with β-thalassemia [genotype, IVS2-654(βo/βE), kindly provided to us by Dr. Edmond Ma, Queen Mary Hospital, Univ. of Hong Kong]. These studies provide proof-of-principle evidence that the transmembrane transport function of microbial toxins (e.g. Anthrax PA) can be harnessed to deliver antisense PNA oligomers effectively into cells. Since microbial toxin proteins can be molecularly engineered to achieve cell selective binding (as exemplified by the IL2-diphtheria fusion toxin, ONTAK®), our findings support the possibility that novel therapeutic agents, based on PNA oligomer constructs and modified microbial toxin proteins, can be developed that combine both genetic targeting and cell selectivity.
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Corash, Laurence, Joycelyn Sim, Wai-Chiu Tsoi, Cheuk Kwong Lee, Rock Y. Y. Leung, Yingjie Liu, Norman Huang, et al. "A Sequential Cohort Study of Pathogen Reduced Platelet Component Transfusion without Use of Leukocyte Reduction for Hematopoietic Stem Cell Transplant (HSCT): Impact on Clinical Refractoriness." Blood 132, Supplement 1 (November 29, 2018): 1257. http://dx.doi.org/10.1182/blood-2018-99-112305.
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Abstract Introduction: HSCT patients require platelet components (PC) for support of thrombocytopenia. Donors are tested for selected viruses to prevent transfusion-transmission infection (TTI), and PC are screened for bacteria and irradiated to prevent transfusion associated graft versus host disease (TA-GVHD). Leukocyte reduction (LR) is commonly, but not universally, used to mitigate the risks of acute transfusion reactions (ATR), allo-immunization, clinical refractoriness, and CMV TTI. However, donor testing, PC bacterial screening, and LR do not provide complete protection from ATR, transfusion related sepsis (TRS), refractoriness, CMV TTI, or residual risks of window period and emerging pathogen TTI. Amotosalen-UVA pathogen reduction treatment (A-PRT) inactivates a broad spectrum of pathogens (e.g. Zika), inhibits leukocyte antigen presentation and cytokine synthesis, and inhibits T-cell proliferation. A-PRT with LR has replaced bacterial screening, CMV serology, and gamma irradiation. Objective: To control cost, the Hong Kong Red Cross Blood Transfusion Service (HKRCBTS) has used whole blood platelet-rich-plasma (PRP) PC without LR. Based on data showing effective leukocyte inactivation by A-PRT, the HKRCBTS evaluated use of A-PRT buffy coat PC (BC PC) in platelet additive solution (PAS) without LR, bacterial screening, and gamma irradiation to manage costs, salvage more donor plasma, reduce TTI risk, and simplify production. Study Design and Methods : An open-label, prospective, sequential, two cohort study at Queen Mary Hospital, Hong Kong enrolled HSCT patients for up to 30 days of PC support with 100-day follow up. Cohorts were comparable for primary disease and type of HSCT. The first cohort received PRP PC prepared from CPD whole blood, a current HKRCBTS standard PC (Control-C). Five ABO-matched PRP PCs in 100% plasma were pooled without LR to yield ≥ 3 x 1011 platelets. C-PCs were screened for bacteria, gamma irradiated (2,500 cGy), stored up to 5 days at 22- 24 °C; and contained ~ 5 x 109 leukocytes. For the 2nd cohort, buffy coat PCs (BC PC) were prepared from CPD whole blood in PAS (SSP+, Macopharma, France). Five ABO-matched BC PC in 35% plasma-65% PAS were pooled, and prepared with A-UVA PRT to yield ≥ 3 x 1011 platelets (Test-T). T-PCs were not LR, not screened for bacteria, not gamma irradiated, stored for up to 5 days at 22- 24 °C; and contained ~ 5 x 108 leukocytes. HSCT patients ≥ 18 years expected to require PC were included. Exclusion criteria were: history of clinical refractoriness to platelet transfusion (2 successive 1-HR corrected count increments (CCI) < 5.0 x 103), immune thrombocytopenia, or disorders confounding 1-HR CCI determination. For both cohorts, a transfusion threshold of 10 x 109/L was specified for stable patients unless adjusted to 20 x 109/L for sepsis. Patients were not screened for HLA antibody at study entry. The efficacy outcome was the 1-hour (HR) count increment (CI), and the safety outcome was ATR incidence. Secondary (post-hoc) outcomes were the 1-HR CCI and the incidence of clinical refractoriness (two successive CCI < 5x103 per patient and transfusions with CCI < 5x103). Results: 64 patients were transfused (31 Control and 33 Test). Demographics were similar between cohorts (Table). The majority of patients had allogeneic HSCT from related donors. Mean pre-transfusion platelet counts were < 16 x 109/L. The mean PC dose and storage duration were similar between cohorts (Table). The 1-HR count increments (CI) and 1-HR CCI responses were within therapeutic ranges for both cohorts (Table). The proportion of transfusions with CCI responses < 5.0 x 103 and the proportion of patients with clinical refractoriness were less in the Test cohort (Table). ATRs trended lower with A-PRT (Test = 9.1%, Control = 19.4%, p=0.296).No patients had TRS or TA-GVHD reported during the active transfusion period. Day-100 engraftment (Table), HSCT-GVHD, mortality, and infectious disease complications were similar between cohorts. Conclusions: This exploratory study of A-PRT PC without LR demonstrated therapeutic 1-HR CCI responses, safety, and conserved HSCT engraftment. The proportions of transfusions with CCI < 5.0x103 and the proportion of patients with clinical refractoriness were less for A-PRT PC than conventional PC. A-PRT of pooled whole blood BC PC without LR offers the potential to improve PC supply, and to reduce the net cost of PRT PC by replacing other interventions. Table Table. Disclosures Corash: Cerus Corporation: Employment, Equity Ownership. Liu:Cerus Corporation: Employment, Equity Ownership. Huang:Cerus Corporation: Employment, Equity Ownership. Vermeij:Cerus Corporation: Employment, Equity Ownership. Stassinopoulos:Cerus Corporation: Employment, Equity Ownership. Benjamin:Cerus Corporation: Employment, Equity Ownership.
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Chan, Man-Hong Helen, Sze-Man June Lau, Yi-Tin Chen, Chi-Chung Chan, Cheuk-Hung Chan, and Yim-Kwan Lam. "Thrombosis Is Uncommon in Chinese Patients Receiving Thalidomide- Experience in a Regional Hospital in Hong Kong." Blood 106, no. 11 (November 16, 2005): 5149. http://dx.doi.org/10.1182/blood.v106.11.5149.5149.
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Abstract OBJECTIVE: To determine the incidence of venous thromboembolism and other side effects of thalidomide in Chinese population Setting: Queen Elizabeth Hospital, Hong Kong SAR. Subjects and Methods: Patients who had received thalidomide from 2001 to 2005 were evaluated in this retrospective study. Thalidomide was given either as a single agent at a dose of 100–400mg/day (median dose: 200mg; mean dose: 257.3mg) or in a combination with dexamethasone at a dose of 20– 40mg (oral) on days 1–4. A minimum of 4 weeks of duration of thalidomide was recruited for assessment. Toxicities were graded according to WHO criteria. Results: Of the 55 patients recruited, 41 patients were evaluable for assessing side effects. The diagnosis of our patients included myelodysplastic syndrome (1/41, 2.4%) refractory mantle cell lymphoma (1/41, 2.4%); myelofibrosis (6/41, 14.6%); and multiple myeloma (33/41, 80.5%). Nine (22%) patients received thalidomide as first line therapy. Thirty-two (78%) patients received thalidomide as 2nd line therapy. Thirty-four (82.9%) patients used thalidomide as single agent. Seven (17.1%) patients used thalidomide as combination therapy. Duration of thalidomide treatment ranged from 4 weeks to 219.3 weeks (Mean 29.4 weeks, median: 20 weeks ). The most commonly observed toxicities were constipation (51.2%), somolence (24.4%), peripheral neuropathy (22%). Only one (2.4%) patient who suffered from myeloma complicated by Miller Fisher syndrome and tetraplegia developed deep vein thrombosis after 4 weeks treatment with thalidomide (300mg/day) plus oral dexamethasone. Conclusion: Chinese patients in our center tolerated thalidomide well. The low incidence of venous thrombosis observed suggests that anticoagulant prophylaxis may not be warranted in Chinese patiens.
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Fu, Y. T., P. P. So, and F. Cheung. "Planned stereotactic radiotherapy (SRT) boost for early T-stage nasopharyngeal carcinoma (NPC), experience of queen elizabeth hospital, Hong kong sar, China." International Journal of Radiation Oncology*Biology*Physics 54, no. 2 (October 2002): 171. http://dx.doi.org/10.1016/s0360-3016(02)03354-0.
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So, P. P., Y. T. Fu, S. Yau, and F. Y. Cheung. "Stereotactic radiotherapy boost for nasopharyngeal carcinoma patients with persistent local disease after primary external radiotherapy, experience of Queen Elizabeth hospital, Hong Kong SAR, China." International Journal of Radiation Oncology*Biology*Physics 54, no. 2 (October 2002): 286. http://dx.doi.org/10.1016/s0360-3016(02)03553-8.
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Chau, HW, and KK Choi. "Efficacy and Safety of Tenectaplase versus Streptokinase in Treating ST-Elevation Myocardial Infarction Patients in Hong Kong: A Four-Year Retrospective Review in Queen Elizabeth Hospital." Hong Kong Journal of Emergency Medicine 20, no. 6 (November 2013): 359–63. http://dx.doi.org/10.1177/102490791302000605.
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Cheung, F., S. F. Liu, K. C. Ngan, F. Lee, C. L. Chan, K. H. Wong, S. K. Au, and C. K. Law. "2019 Early clinical outcome of simultaneous modulated accelerated radiation therapy (SMART) intensity modulated radiotherapy (IMRT) for nasopharyngeal Carcinoma (NPC) in Queen Elizabeth Hospital (QEH), Hong Kong." European Journal of Cancer Supplements 7, no. 2 (September 2009): 157. http://dx.doi.org/10.1016/s1359-6349(09)70535-x.
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