Journal articles on the topic 'Quantificatori'

The carbon nanotube (CNT) structure is a promising building block for future nanocomposite structures. Mechanical properties of the electrospun butadiene elastomer reinforced with CNT are analyzed by multiscale method. Effective properties of the fiber at microscale determined by homogenization procedure using modified shear-lag model, while on the macro scale effective properties for the point-bonded stochastic fibrous network determined by volume homogenization procedure using multilevel finite element. Random fibrous network was generated according experimentally determined stochastic quantificators. Influence of CNT reinforcement on elastic modulus of electrospun sheet on macroscopic level is determined.

Often the input values used in mathematical models for rolling bearings are in a wide range, i.e., very small values of deformation and damping are confronted with big values of stiffness in the governing equations, which leads to miscalculations. This paper presents a two degrees of freedom (2-DOF) dimensionless mathematical model for ball bearings describing a procedure, which helps to scale the problem and reveal the relationships between dimensionless terms and their influence on the system’s response. The derived mathematical model considers nonlinear features as stiffness, damping, and radial internal clearance referring to the Hertzian contact theory. Further, important features are also taken into account including an external load, the eccentricity of the shaft-bearing system, and shape errors on the raceway investigating variable dynamics of the ball bearing. Analysis of obtained responses with Fast Fourier Transform, phase plots, orbit plots, and recurrences provide a rich source of information about the dynamics of the system and it helped to find the transition between the periodic and chaotic response and how it affects the topology of RPs and recurrence quantificators.

Various studies have shown that swimming pool mismanagement could serve as medium for water-borne diseases transmission. The research aimed to assess the biological quality of public swimming pool water in Tangerang city. One public swimming pool at the center of Tangerang city was assessed during November – December 2016 by adding two parameters to routine bacteriological indicators assessed by Tangerang city Heath Official in publicfacilities. Nine samples taken from three points in the swimming pool at three time periods, i.e. before, after, and during operational hours were analysed in the laboratory for detection and quantificaton of bacteriological indicators of swimming pool water, i.e. coliform, Escherichia coli, Staphylococcus, and Pseudomonas aeruginosa. Results showed that the number of total coliform and Escherichia coliof the public swimming pool exceeded WHO guidelines but not Peudomonas and Staphylococcus. Therefore,the disinfection, cleaning, and monitoring procedures need to be improved as well as increasing public swimming pool users education about the risk of potential transmissible diseases in public swimming pool.

The article deals with the perfume and cosmetic name corpus research in the aspect of parametrization in multiaspective and multistructural ways. Multiaspective peculiarities are divided into naming and informational aspects. Multistructural features are reflected in the combination of A-brand (manufacturer), B-basic (individual), C-genitive (article), D-functional-descriptive integrants. The next level of multistructural features is connected with the combination of integrants into bigger structures, they are integrators. They are associated within the huge article unit name corpus. The corpus itself consists of such semantic components as quantificators, qualificators, determinatives. Naming integrator corpus provides the discrimination of article units, and demonstrates the involvement of naming devices and some shade of social stratification. Involvement of naming register is reflected in the corpus too. Article units are associated with their naming integrators. In the process of research there were two stages of selection. The primary stage identified 54 classes of goods. The secondary one identified 13 leading classes of olfactory and colouring goods. Parameters which are identified in the process of parametrization may be qualitative and quantitative in their mutual functioning and correlation. Quality and quantity are reflected in goods types, naming devices, naming register. The goods name corpus is a stock of information, knowledge about article units. The informational nucleus is created with two subgroups. The first subgroup represents some information about olfactory, aroma, fragrance, odour. The second one contains some information about optical effect, colouring, tinting, masking.

L'elevato peso atomico del Gd giustifica l'ipotesi di un utilizzo in tomografia computerizzata (TC) di mezzi di contrasto (MdC) già clinicamente in uso in risonanza magnetica (RM). Il potenziamento TC determinato dalla Gadodiamide (Gd-DTPA-BMA, Omniscan, Nycomed-Amersham), MdC paramagnetico non ionico, è stato valutato e quantificato in vitro e in vivo. Due serie di soluzioni scalari di Gadodiamide e di MdC iodato (Iopamiro 370, Bracco) sono state sottoposte a scansione TC per la quantificazione densitometrica in unità Hounsfield (UH). Sette pazienti affetti da neoplasia intracranica sono stati sottoposti a TC prima e dopo somministrazione endovenosa di 0,3 mmol/Kg di Gadodiamide; sono stati rilevati i valori medi di densità pre- e postcontrasto a livello dell'arteria basilare e della massa tumorale. Nello studio in vitro, a parità di concentrazione molare del MdC, è risultata maggiore la densità media della soluzione di gadodiamide rispetto al MdC iodato, superiorità statisticamente significativa (test F, p < 0,0001), a conferma del fatto che il Gd ha caratteristiche fisiche che lo rendono utilizzabile in MdC per TC. Nello studio in vivo, la gadodiamide ha determinato incrementi densitometrici medi (postcontrasto /precontrasto) del 71,05% per l'arteria basilare e del 45,23% per la lesione tumorale, consentendo una sufficiente apprezzabilità soggettiva dell'enhancement. La Gadodiamide può essere utilizzata come MdC in TC in pazienti con dubbia o asserita diatesi allergica per i MdC iodati allorquando non sia praticamente disponibile la RM (urgenze!) o sussistano importanti controindicazioni (pacemaker, ecc.). L'osmolarità medio-bassa (780 mOsm/Kg) e il profilo tossi-cologico favorevole della Gadodiamide permettono di ipotizzare l'utilizzo di dosi anche più elevate. Tali risultati preliminari rafforzano l'ipotesi della messa a punto di MdC per TC a base di Gd; più atomi di Gd potrebbero ad esempio essere contenuti all'interno della molecola con il duplice effetto di ridurre la tossicità ed elevare il peso atomico del MdC. Gadolinium (Gd) high atomic weight can enable us to use the Gd-chelates as contrast agents (c.a.) in computed tomography (CT). CT contrast enhancement (c.e.) due to Gadodiamide (Gd-DTPA-BMA, Omniscan, Nycomed-Amersham), a non-ionic paramagnetic c.a. used in magnetic resonance (MR) imaging, was evaluated and quantified through an in vitro and in vivo study.

Abstract Introduction: Fusion transcript is a chimeric RNA encoded by a fusion gene or by two different genes by subsequent trans-splicing. Detection of fusion transcripts is an integral part of routine diagnostics of hematological malignancies. However, most of previous analytical methods couldn't detect all fusion transcripts in leukemia. In this study, we developed accurate fusion transcript detection methood using whole transcriptome sequencing, fusion gene detection software and expression analysis. Methods: RNA sequencing (RNA-seq) for whole transcriptome was performed in 11 patients with hematological malignancies (4 AML, 2 APL, 2 ALL, and 3 CML) having fusion transcripts detected by multiplex RT-PCR (HemaVision, DNA Diagnostic, Risskov, Denmark). Library were prepared with 1 ug of total RNA for each sample by TruSeq mRNA Sample Prep kit (Illumina, San Diego, USA). The libraries were quantified using qPCR according to the qPCR Quantification Protocol Guide (KAPA Library Quantificatoin kits for Illumina Sequecing platforms) and qualified using the TapeStation D1000 ScreenTape (Agilent Technologies, Santa Clara, USA). Indexed libraries were then sequenced using the HiSeq2500 platform (Illumina). The data obtained from the sequencing was analyzed using STAR-Fusion (v1.2.0). Novel fusion transcripts were confirmed by conventional sequencing. Results: Using STAR-Fusion, average number of fusion candidates per sample was 949.8 (range, 286-1752). To exclude false positive results and obtain true positive results, we developed the following filtering algorithm. First filtering criterion is to have more than 5 junction reads, the second is to detect more than one number of spanning reads, and the third criterion is to be in-frame fusion, which type of fusion can actually synthesize intact protein. Fusion candidates remaining after applying the above three filtering criteria were 1-3 per sample. All known fusion transcripts (PML--RARA, RUNX--RUNX1T1, CBFB--MYH11, KMT2A--MLLT3, BCR--ABL1, DEK--NUP214, ETV6--RUNX1) by multiplex RT-PCR were also detected in RNA-seq. In addition, 10 novel fusion transcripts (IGKV4-1--IGKC, IGLV1-47--IGLC2, HBA2--HBB, DEFA3--MBNL1, HBB--HBA2, MPO--HBA2, HBS1L--AHI1, HBB--HBA2, IGKV4-1--IGKC, SS18L1--ADRM1) were detected and among them, 6 fusions were confirmed by conventional sequencing. Conclusions: Whole transcriptome sequencing and optimized filtering algorithms successfully detected all known fusion transcripts and various novel fusions. Disclosures No relevant conflicts of interest to declare.

Negli ultimi anni lo studio dei meccanismi di recupero funzionale dopo ictus è progredito grazie all'utilizzo di nuove tecniche di indagine sia con immagini che con registrazione elettrofisiologiche. L'interesse è accentuato dal potenziale utilizzo di queste conoscenze per mettere a punto opportuni programmi terapeutici e riabilitativi. Scopo di questo lavoro è stato quello di indagare mediante Risonanza Magnetica funzionale (fMR) quali aree motorie fossero coinvolte nel recupero dopo ictus cerebrale. Sono stati studiati 10 pazienti con ictus sottocorticale ischemico (5 con emiparesi destra e 5 con emiparesi sinistra) in buon recupero funzionale. L'età media era 59,1 anni (min 37, max 84). Tutti i pazienti sono stati indagati effettuando uno studio per immagini e funzionale. La fMR è stata realizzata con apparecchiatura General Electric 1,5 T mediante sequenze SPGR (TR/TE 64/48 ms, Flip Angle 17°, FOV 22×6 cm2, matrice 256times128, spessore di strato 6 mm) costituite da 3 sezioni assiali oblique contigue, parallele alla linea inter-commissurale, condotte a livello della corteccia motoria. L'esame funzionale è stato preceduto da uno studio convenzionale utilizzato per dimostrare le lesioni, per programmare le sequenze funzionali e per fornire una correlazione anatomica ai pixel attivati. La fMR è stata effettuata alternando acquisizioni ottenute durante un movimento delle dita con sequenze eseguite in condizioni di riposo sia per la mano paretica che per quella sana. Per l'elaborazione è stata usata la tecnica “cross correlation” con soglia usando la “box-car” come forma d'onda di riferimento. Sono stati considerati “attivati” i pixel con coefficiente di correlazione (CC) ≥ 70% del CC massimo. I pixel selezionati, codificati mediante colorazione e sovrapposti alle immagini anatomiche, sono stati quantificati con apposito programma, suddivisi per aree motorie corticali. I risultati hanno evidenziato un'attivazione bilaterale durante il movimento della mano paretica mentre si è registrata un'attivazione controlaterale più selettiva durante il movimento della mano sana. Nell'emisfero omolaterale alla paresi si è inoltre rilevato un incremento dell'attivazione nelle aree premotoria e supplementare motoria. Questi dati sembrerebbero dimostrare che una maggiore attivazione delle aree motorie corticali omolaterali alla lesione sia un importante meccanismo di compenso al danno funzionale conseguente ad ictus. Tale attivazione può avere un duplice significato: un rinforzo delle vie discendenti cortico-spinali già presenti nel soggetto sano e un ausilio funzionale da parte delle aree premotoria e supplementare motoria verso il lato lesionato.

Silence is often described as to be some kind of important and powerful phenomenon or acoustic appearance in music therapy and of course in other disciplines too. Therefore, it is pertinent to gain more knowledge about how people perceive silence, what effects it has on the individual’s levels of relaxation and human perception of self, time and space. Silence lasting 6:30 minutes preceded by two different conditions consisting of either a university seminar or a session of Depth Relaxation Music Therapy (DRMT) were the two arms of this study carried out at a university with students as subjects. The silence after the DRMT was judged more relaxing than the silence after the seminar. Participants also had a lower sense of space and time, as well as a reduced future perspective. They estimated the silence as having lasted longer in the condition following the DRMT session. These effects support further investigations concerning the idea that silence (combined with DRMT) may be of preventive (e.g. regarding stress-related diseases, depression, burnout and anxiety disorders), relaxing and health-promoting interest for clinical and non-clinical applications. Keywords: relaxation, music therapy, silence, time, hypnotherapySpanishCambios en el estado de conciencia durante un Período de Silencio , luego de una sesión de Depth Relaxation Music Therapy (DRMT – Relajación Profunda Musicoterapia)El silencio es descripto a menudo como un tipo de fenómeno importante y poderoso o como una aparición acústica en musicoterapia y por supuesto en otras disciplinas también. Por lo tanto, es pertinente contar con más conocimiento sobre cómo las personas perciben el silencio, qué efectos tiene en los niveles de relajación y en la percepción del self, del tiempo y del espacio del individuo. En este estudio, realizado con estudiantes universitarios como sujetos, se realiza un periodo de silencio de 6:30 minutos despues de dos condiciones diferentes: un seminario universitario o una sesión de Depth Relaxation Music Therapy (DRMT). El silencio despues de DRMT se percibió como más relajante que el silencio despues del seminario. Los participantes también tuvieron una menor sensación de espacio y tiempo , así como una perspectiva de futuro reducida. Los autores estimaron que el silencio había durado menos tiempo después de la sesión de DRMT. Estos efectos promueven investigaciones concernientes a que la idea de que el silencio (combinado con DRMT) puede ser preventivo (por ejemplo; enfermedades relacionadas al stress, depresión , burnout, y trastornos de ansiedad), ser relajante y promover el interés por la salud para aplicaciones clínicas y no clínicasPalabras claves: Relajación , musicoterapia, silencio , tiempo , hipnosis GermanVeränderungen im Bewusstseinszustand während einer Periode der Stille nach einer Sitzung tiefenentspannter Musiktherapie (DRMT)Eric PfeiferStille wird oft als eine Art wichtiges und kraftvolles Phänomen oder akustische Erscheinung in der Musiktherapie beschrieben, und natürlich auch in anderen Disziplinen. Deshalb ist es angemessen, mehr Wissen über Menschen zu erlangen, die Stille erfahren haben – was für Effekte dies auf den individuellen Level an Entspannung und menschliche Erfahrungen von Selbst, Zeit und Raum hat. Die 6,30 minütige Stille , die zwei verschiedenen Bedingungen, bestehend aus einem universitären Seminar oder einer Sitzung von tiefenentspannter Musiktherapie (DRMT) vorausging, bildeten die zwei Teile dieser Studie, die mit Studenten der Universität durchgeführt wurde. Die Stille nach der DRMT wurde als entspannender bewertet als die Stille nach dem Seminar. Die Teilnehmer hatten auch weniger Gefühl für Zeit und Raum, ebenso wie eine reduziertere Zukunftsperspektive. Sie erlebten die Stille in der Zeit die der DRMT folgte, als länger andauernd. Diese Effekte unterstützen zukünftige Untersuchungen die Idee betreffend, dass Stille (zusammen mit DRMT) präventive (z.B. für stress-bedingte Krankheiten, Depression, Burnout und Angststörungen), entspannende und gesundheitsfördernde Bedeutung für klinische und nicht-klinische Anwendungen haben könnte.Keywords: Entspannung, Musiktherapie, Stille, Zeit, Hypnotherapie ItalianVariazione dei Stati di Coscienza nel corso di un Periodo di Silenzio dopo una sessione di Depth Relaxation Music Terapy (DRMT) , (Musicoterapia e Rilassamento Profondo)Eric PfeiferIl silenzio è spesso descritto come un fenomeno molto importante e potente, o un aspetto acustico in musicoterapia e naturalmente anche in altre discipline. Perciò è il caso di acquisire maggiori informazioni su come le persone percepiscono il silenzio, quali effetti ha sui livelli individuali di relax e di percezione umana del tempo e dello spazio. Il silenzio di una durata di 6:30 minuti preceduto da due differenti condizioni consistenti in un seminario universitario o in una sessione di Depth Relaxation Music Therapy (DRMT) erano i due diversi modi di effettuare lo studio presso un universitá con gli studenti. Il silenzio dopo la DRMT è stato giudicato più rilassante rispetto al silenzio dopo il seminario. I partecipanti hanno anche avuto una bassa percezione dello spazio e del tempo, e anche una bassa percezione del futuro. Essi hanno quantificato che il silenzio fosse durato più a lungo dopo aver fatto la sessione di DRMT. Questi effetti supportano ulteriori indagini in materia circa l’idea che il silenzio (in combinazione con la DRMT) può essere di prevenzione (ad esempio per quanto riguarda disagi legati allo stress, depressione, esaurimenti e disturbi d’ansia), rilassante e salutare per applicazioni cliniche e non. Parole Chiave: relax, musicoterapia, silenzio, tempoChinese深度放鬆音樂治療(DRMT)後靜默時間內的意識狀態變化 靜默在音樂治療中常被描述為重要而有力的現象且具有聽覺上的存在感，在其他領域中也常被提及。因此，我們對於人們如何感知靜默需要更多的認識，究竟一個人的放鬆程度以及對自我、時間和空間的觀感如何影響了他對靜默的感知。本研究以大學生為對象，參與者在大學的研討會或深度放鬆音樂治療這兩種不同的情境之後保留為時六分三十秒的靜默時間。跟參加研討會之後的靜默感知相比，在深度放鬆音樂治療之後的靜默被認為感覺較為放鬆。參與者較少感受到空間與時間，也降低了未來感。參與者預期深度放鬆音樂治療之後的靜默時間是比較長的。這些影響可用來支持未來關於靜默的討論研究(與DRMT結合)，激發人們對於靜默的臨床與非臨床應用的興趣，並用於預防性治療(例如，壓力相關疾患、憂鬱、倦怠或焦慮疾患)，放鬆與促進健康 。JapaneseDepth Relaxation Music Therapy (DRMT)後のサイレンス期間における意識状態の変化Eric Pfeifer サイレンスは度々音楽療法においてある種の重要性、効果現象もしくは音響的輪郭があると描写され、それは他の専門分野においても同様である。それゆえ、人々がどのようにサイレンスを認識するのか、また、何がリラクゼーションの 個人レベル、そして、人間の自己、時間、空間への知覚に影響するのか、さらなる知識を増やすことは適切である。サイレンスは6分30秒の長さで、大学でのセミナー、もしくはDRMTのセッション後という2つの異なった状態で構成され、本研究は大学で学生を被験者として実地された。DRMT後のサイレンスはセミナーの後のサイレンスよりリラックスできると判断された。被験者は空間と時間の知覚が低く、将来への見通しも縮小した。これらの効果は、サイレンス （DRMTとの組み合わせ）は予防的（例：ストレス関連疾患、鬱、バーンアウト症候群、不安障害など）である可能性があること、臨床と非臨床のためのリラクゼーションと健康促進の適用のための重要性があることの考察について、将来の調査を支援する。 Keywords: relaxation, music therapy, silence, time, hypnotherapyキーワード：リラクゼーション、音楽療法、サイレンス、時間、催眠療法 KoreanDepth Relaxation 심층 이완 음악 치료(DRMT) 세션 이후 침묵하는 동안 의식 상태에 생긴 변화Eric Pfeifer침묵은 다른 분야는 물론 음악 치료에서 중요하고 강력한 현상 또는 음향적 식별로 종종 설명이 되곤 한다. 따라서 어떻게 사람들이 침묵을 인식하는 지, 침묵이 개인의 이완 수준과, 자아, 시간, 공간에 대한 인간의 인식에 어떠한 영향을 끼치는 지에 대해 좀 더 많은 지식을 얻는 것이 적합하다. 대학 세미나나 Depth Relaxation Music Therapy(DRMT) 세션으로 구성된 두 가지의 다른 조건을 실시한 후 6시간 30분 동안 지속된 침묵이, 한 대학교에서 학생들을 대상으로 실시한 본 연구의 두 가지 부분이다. DRMT 후 침묵은 세미나 후 침묵보다 더 이완을 시켜주는 것으로 나타났다. 또한 참가자들은 미래에 대한 관점이 줄어들었을 뿐만 아니라 더 낮은 시간과 공간 인식을 가지고 있었다. 그들은 DRMT 세션 종료 상황에서 침묵이 더 오래 지속되었다고 평가했다. 이런 효과는 침묵(DRMT와 접목시킨)이 임상학적으로나 비임상학적으로 예방해주고(예, 스트레스 관련 질병, 우울증, 불안 장애, 극도의 피로) 이완시켜주고, 건강을 증진시키는 효과가 있을 수 있다는 생각과 관련된 추후 조사들을 뒷받침해준다.키워드: 이완, 음악 치료, 침묵, 시간, 최면요법

Objective Objective differentiation between unilateral coronal synostosis (UCS) and positional posterior plagiocephaly (PPP) based on 3D photogrammetry according to Utrecht Cranial Shape Quantificator (UCSQ). Design Retrospective study. Setting Primary craniofacial center. Patients, Participants Thirty-two unoperated patients (17 UCS; 15 PPP) (age < 1 year). Interventions Extraction of variables from sinusoid curves derived using UCSQ: asymmetry ratio forehead and occiput peak, ratio of gradient forehead and occiput peak, location forehead and occiput peak. Main Outcome Measure(s) Variables, derived using 3D photogrammetry, were analyzed for differentiation between UCS and PPP. Results Frontal peak was shifted to the right side of the head in left-sided UCS (mean x-value 207 [192-220]), and right-sided PPP (mean x-value 210 [200-216]), and to the left in right-sided UCS (mean x-value 161 [156-166]), and left-sided PPP (mean x-value 150 [144-154]). Occipital peak was significantly shifted to the right side of the head in left-sided PPP (mean x-value 338 [336-340]) and to the left in right-sided PPP (mean x-value 23 [14-32]). Mean x-value of occipital peak was 9 (354-30) in left- and 2 (350-12) in right-sided UCS. Calculated ratio of gradient of the frontal peak is, in combination with the calculated asymmetry ratio of the frontal peak, a distinctive finding. Conclusions UCSQ objectively captures shape of synostotic and positional plagiocephaly using 3D photogrammetry, we therefore developed a suitable method to objectively differentiate UCS from PPP using radiation-free methods.

Abstract Purpose The aim is to implement Utrecht Cranial Shape Quantificator (UCSQ) for quantification of severity of scaphocephaly and compare UCSQ with the most used quantification method, cranial index (CI). Additionally, severity is linked to intracranial volume (ICV). Methods Sinusoid curves of 21 pre-operative children (age < 2 years) with isolated scaphocephaly were created. Variables of UCSQ (width of skull and maximum occiput and forehead) were combined to determine severity. CI was calculated. Three raters performed visual scoring for clinical severity (rating of 6 items; total score of 12 represents most severe form). Pearson’s correlation test was used for correlation between UCSQ and visual score and between both CIs. ICV was calculated using OsiriX. ICV was compared to normative values and correlated to severity. Results Mean UCSQ was 22.00 (2.00–42.00). Mean traditional CI was 66.01 (57.36–78.58), and mean visual score was 9.1 (7–12). Correlations between both traditional CI and CI of UCSQ and overall visual scores were moderate and high (r = − 0.59; p = 0.005 vs. r = − 0.81; p < 0.000). Mean ICV was 910 mL (671–1303), and ICV varied from decreased to increased compared to normative values. Negligible correlation was found between ICV and UCSQ (r = 0.26; p > 0.05) and between ICV and CI and visual score (r = − 0.30; p > 0.05 and r = 0.17; p > 0.05, respectively). Conclusion Our current advice is to use traditional CI in clinical practice; it is easy to use and minimally invasive. However, UCSQ is more precise and objective and captures whole skull shape. Therefore, UCSQ is preferable for research. Additionally, more severe scaphocephaly does not result in more deviant skull volumes.