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Journal articles on the topic 'QT.37'

Author: Grafiati

Published: 22 June 2023

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1

Licata, Anthony, and Alistair Savage. "Hecke algebras, finite general linear groups, and Heisenberg categorification." Quantum Topology 4, no. 2 (2013): 125–85. http://dx.doi.org/10.4171/qt/37.

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Séguéla, Pierre-Emmanuel, Jean-Christophe Rozé, and Véronique Gournay. "Evolution of the QT interval in premature infants: a preliminary study." Cardiology in the Young 22, no. 4 (2011): 430–35. http://dx.doi.org/10.1017/s1047951111001958.

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AbstractBackgroundThe association between long QT interval and sudden infant death syndrome has been clearly established. Several studies have been conducted to determine the evolution of the QT interval in childhood from birth, but only in full-term newborns. However, data on the QT interval in pre-term infants are extremely scarce. The objective was to describe the development of the QT interval in premature infants.Material and methodsIn a prospective monocentric study in a neonatal intensive care unit, pre-term newborns born before 37 weeks of gestation without congenital heart disease, fa

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Orosz, Andrea, István Baczkó, Viktória Nagy, et al. "Short-term beat-to-beat variability of the QT interval is increased and correlates with parameters of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy." Canadian Journal of Physiology and Pharmacology 93, no. 9 (2015): 765–72. http://dx.doi.org/10.1139/cjpp-2014-0526.

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Stratification models for the prediction of sudden cardiac death (SCD) are inappropriate in patients with hypertrophic cardiomyopathy (HCM). We investigated conventional electrocardiogram (ECG) repolarization parameters and the beat-to-beat short-term QT interval variability (QT-STV), a new parameter of proarrhythmic risk, in 37 patients with HCM (21 males, average age 48 ± 15 years). Resting ECGs were recorded for 5 min and the frequency corrected QT interval (QTc), QT dispersion (QTd), beat-to-beat short-term variability of QT interval (QT-STV), and the duration of terminal part of T waves (

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4

Olson, Stephen C., Ann Marie Horvath, Barbara M. Michniewicz, et al. "The Clinical Pharmacokinetics of Quinapril." Angiology 40, no. 4_part_2 (1989): 351–59. http://dx.doi.org/10.1177/000331978904000404.

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Quinapril (Q) and quinaprilat (QT) pharmacokinetics are dose pro portional following single oral 2.5- to 80-mg Q doses. Q absorption and hy drolysis to QT is rapid with peak Q and QT concentrations occurring one and two hours postdose, respectively. Peak plasma QT concentrations were approximately fourfold higher than those of Q (923 vs 207 ng/mL follow ing 40-mg Q). Dose-proportional QT area under the curve and dose-inde pendent percent of dose excreted in urine as QT demonstrate that the ex tent of Q conversion to QT is con stant over the dose range studied. Q and QT were eliminated from pla

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Arpaci, Dilek, Mustafa Volkan Demir, Tayfun Garip, and Ali Tamer. "A Case of QT Prolongation Associated with Panhypopituitarism." Case Reports in Endocrinology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/989745.

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We describe a 37-year-old patient with panhypopituitarism who experienced symptoms and signs of hormonal insufficiency and QT prolongation on electrocardiogram without electrolyte disturbances. After hormonal (steroidal and thyroid) replacement therapy electrocardiographic findings were normalized. Hormonal disorders should be considered as a cause of long QT intervals which may lead to torsade de pointes, even if plasma electrolyte levels are normal, because life-threatening arrhythmia is treatable by supplementation of the hormone that is lacking.

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SOYSAL GÜNDÜZ, Özgül, and Kezban ARMAGAN. "Increased QT dispersion and related factors in patients with systemic sclerosis." Anatolian Current Medical Journal 4, no. 4 (2022): 368–73. http://dx.doi.org/10.38053/acmj.1132856.

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Introduction: Cardiac arrhythmias and sudden death may occur as a result of ventricular myocardial fibrosis or ischemia in patients with systemic sclerosis (SSc). QT prolongation and QT dispersion, which facilitate the development of ventricular fibrillation, are important cardiac problems associated with increased mortality. In this study, we aimed to investigate the prevalence of corrected QT dispersion (cQTD) and related factors in our patients with systemic sclerosis compared to healthy controls. Material and Method: The 12-lead electrocardiograms with a rate of 25 mm/s of patients w

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Shea, Kevin G., Jessica F. Burlile, Connor G. Richmond, et al. "Quadriceps Tendon Graft Anatomy in the Skeletally Immature Patient." Orthopaedic Journal of Sports Medicine 7, no. 7 (2019): 232596711985657. http://dx.doi.org/10.1177/2325967119856578.

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Background:The quadriceps tendon (QT) is increasingly considered for primary and revision anterior cruciate ligament reconstruction in skeletally immature patients, as it may be harvested as a purely soft tissue graft with considerable tissue volume. Because of distinct rectus tendon (RT) separation from the QT complex, the potential for RT retraction exists and could lead to QT weakness after QT graft harvest.Purpose:To describe the anatomy of the pediatric QT and clarify decussation of the RT and QT to avoid the risk of delayed RT retraction and QT weakness after QT graft harvest.Study Desig

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Määttänen, Ilmari, Niklas Ravaja, Pentti Henttonen, et al. "Type 1 long QT syndrome and psychological stress in a laboratory setting." Journal of Health Psychology 25, no. 9 (2018): 1213–21. http://dx.doi.org/10.1177/1359105317751617.

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Trait-like sensitivity to stress in long QT syndrome patients has been documented previously. In addition, mental stress has been associated with symptomatic status of long QT syndrome. We examined whether the symptomatic type 1 long QT syndrome patients would be more sensitive to mental stress compared to asymptomatic patients and whether there would be differences in task-related physiological stress reactions between type 1 long QT syndrome patients and healthy individuals. The study population consisted of 21 symptomatic and 23 asymptomatic molecularly defined KCNQ1 mutation carriers, thei

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Brady, William, Daniel DeBehnke, Dennis Laundrie, and Jeffrey A. Skiles. "21. Prolonged QT Intervals in Patients with Out-of-Hospital Ventricular Tachycardia Cardiac Arrest." Prehospital and Disaster Medicine 11, S2 (1996): S40. http://dx.doi.org/10.1017/s1049023x00045854.

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Objective: To determine the prevalence and outcome of out-of-hospital ventricular tachycardia (VT) cardiac arrest with a prolonged QT interval and to identify the subset with torsades de pointes (TdP).Methods: Design: Retrospective review. Setting: Fire department-based paramedic system. Participants: Non-traumatic VT cardiac arrest (1/91-12/94) with a supraventricular perfusing rhythm (SVPR) and a measurable QT interval. Interventions: QT interval was measured from a SVPR and corrected QT interval (QTc) was calculated (prolonged if ≥0.45 sec). VT was classified as polymorphic or monomorphic.R

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Rhatomy, Sholahuddin, Roy Lisang, Noha Roshadiansyah Soekarno, and Bambang Kisworo. "Evaluation of Quadriceps Strength Post-medial Patellofemoral Ligament Reconstruction Using Quadriceps Tendon Autografts." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 943–46. http://dx.doi.org/10.3889/oamjms.2020.5551.

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BACKGROUND: Medial patellofemoral ligament (MPFL) reconstruction using quadriceps tendon (QT) grafts provides favorable results with minimal complications and can be performed in patients with open epiphyseal plates. Following MPFL reconstruction using QT grafts, the outcomes have been evaluated, but the residual quadriceps strength (QS) has never been evaluated. AIM: We analyzed the knee’s range of motion (ROM), thigh circumference (TC), and QS at donor leg sites compared with those at contralateral healthy sites after MPFL reconstruction. The hypothesis was that there is no morbidity a

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Choueiri, Toni K., Esteban Walker, Rachid C. Baz, et al. "Aggressive Electrolytes Replacement in Multiple Myeloma (MM) Patients Receiving Arsenic Trioxide (ATO) Containing Regimens Alleviates the Need for Frequent Electrocardiogram (ECG) Monitoring." Blood 106, no. 11 (2005): 5155. http://dx.doi.org/10.1182/blood.v106.11.5155.5155.

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Abstract Background: Arsenic trioxide (ATO) has shown activity in relapsed/refractory multiple myeloma (MM). An uncommon but life-threatening side effect of ATO is arrhythmia such as torsade de pointes (TdP), especially when QT or QTc (heart-rate corrected) intervals >500 milliseconds (ms). We evaluated the incidence and predictors of QT and QTc prolongation in MM patients treated with ATO. Methods: We reviewed prospectively collected demographic, laboratory and 766 weekly-ECG data on 48 patients treated in phase II trials with ATO. Patients received a median of 1.7 cycles (range 1–8) of 0.

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VandenBerg, Curtis D., Mia J. Katzel, Veronica Beltran, Adriana S. Conrad-Forrest, and Tishya A. L. Wren. "EFFECT OF AUTOGRAFT TYPE ON RECOVERY OF KNEE EXTENSOR MECHANISM FUNCTION FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION." Orthopaedic Journal of Sports Medicine 9, no. 7_suppl3 (2021): 2325967121S0009. http://dx.doi.org/10.1177/2325967121s00094.

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Background: While multiple studies have shown clear benefits of autograft over allograft for anterior cruciate ligament reconstruction (ACLR) in young athletes, disagreement remains regarding the optimal autograft choice. Recovery from ACLR may be influenced by autograft type, which can include iliotibial band (IT), hamstring tendon (HT), quadriceps tendon (QT), or patellar tendon (PT) depending on skeletal maturity and surgeon preference. Hypothesis/Purpose: This study compared knee joint function among pediatric athletes with different types of ACLR autografts. We hypothesized that knee exte

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Asefa, G., and M. Beriso. "Evaluation of black cumin genotypes for yield and yield related parameters in bale mid altitude, southeastern Ethiopia." International Journal of Agricultural Research, Innovation and Technology 10, no. 2 (2021): 35–37. http://dx.doi.org/10.3329/ijarit.v10i2.51574.

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Fourteen black cumin genotypes were evaluated against standard checks for two consecutive years during 2018 to 2019 at Sinana, Goro and Gindhir to investigate high yielder and stable black cumin varieties. The mean total seed yield of genotypes across environment ranged from 24.54 to 16.07 Qt ha-1. The highest total seed yield was recorded from genotypes 242826-2 followed by 242826-2 (24.54 and 23.32 Qt ha-1) while the lowest total seed yield was obtained from local checks. These two genotypes have yield advantage of 22.41 and 14.96% over standard check Derbera. Based on their performance acro

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Fialová, Kateřina, Jiří Blahák, Marek Motola, Jiří Jarkovský, Jan Mužík, and Marie Nováková. "Effect of perphenazine on electrogram of rat isolated heart." Acta Veterinaria Brno 80, no. 1 (2011): 87–92. http://dx.doi.org/10.2754/avb201180010087.

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The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg) and 37 °C (CaCl2, 1.2 mM). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were st

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Blich, Miry, Edna Efrati, Ibrahim Marai, Mahmoud Suleiman, Lior Gepstein, and Monther Boulous. "Novel Clinical Manifestation of the Known SCN5A D1790G Mutation." Cardiology 132, no. 4 (2015): 228–32. http://dx.doi.org/10.1159/000437089.

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The D1790G mutation was found in all 24 patients of an extended long QT family but not in 200 chromosomes carried by healthy individuals. We describe a 37-year-old man presenting with a typical spontaneous type 1 Brugada pattern who in electrophysiological testing had easily inducible ventricular fibrillation. At the age of 47 years he had an atrial ventricular type 2 block documented by an exercise test and a Holter monitor. Genetic analysis revealed a known D1790G mutation in the gene encoding of the sodium channel (SCN5A) that until now has been associated only with the long QT phenotype. A

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Valdivieso Lama, Natalia, Carlos Barrionuevo Cornejo, Judith Vidal Ayllon, et al. "Características clínicas y pronóstico de los pacientes con linfoma leucemia de células t del adulto." Oncología (Ecuador) 32, no. 3 (2022): 320–33. http://dx.doi.org/10.33821/657.

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Introducción: El objetivo del presente estudio fue determinar las características clínicas y pronóstico de los pacientes con Leucemia/Linfoma de Células T del Adulto (ATL) en el Instituto Nacional de Enfermedades Neoplásicas (INEN) de Perú. Metodología: Se realizó un estudio transversal, que incluyó por Se revisaron 188 historias clínicas y estudio patológico de pacientes con infección por HTLV-1 diagnosticados en el INEN durante 10 años, de quienes 150 tuvieron ATL. Resultados: 62% de los pacientes tuvieron el subtipo ATL linfoma, 37% subtipo agudo y 1% crónico. La mediana de edad fue 53 años

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Carlile, P. V., S. F. Hagan, and B. A. Gray. "Perfusion distribution and lung thermal volume in canine hydrochloric acid aspiration." Journal of Applied Physiology 65, no. 2 (1988): 750–59. http://dx.doi.org/10.1152/jappl.1988.65.2.750.

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We investigated the effects of a brief period of positive end-expiratory pressure (PEEP) ventilation or nitroglycerin (NTG) infusion on the distribution of pulmonary blood flow and extravascular thermal volume (ETV) in anesthetized dogs with unilateral HCl lung injury. ETV was determined by the thermal dye technique by use of a monoexponential extrapolation to exclude recirculating indicator, and regional blood flow was determined by a particle distribution technique (radiolabeled plastic microspheres). The lungs were weighted after the animals were killed, and extravascular lung mass (ELM) wa

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Gervais, Anne-Sophie, Adrien Flahault, Chan Tevy, et al. "97 Electrocardiographic features at rest and during exercise in young adults born preterm below 30 weeks of gestation." Paediatrics & Child Health 25, Supplement_2 (2020): e40-e41. http://dx.doi.org/10.1093/pch/pxaa068.096.

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Abstract Introduction/Background Preterm birth has adverse consequences on the cardiovascular system. Whether premature birth is associated with conduction and repolarisation abnormalities past childhood and into adulthood still needs to be demonstrated. An exercise test could reveal such abnormalities. Objectives We aimed to assess electrocardiographic changes, particularly corrected QT (QTc) prolongation, in a cohort of young adults born preterm, at rest and during exercise. Design/Methods We analysed the ECG of young adults (23.9±3.1 years) born term (≥37 weeks, n=53) and preterm (&lt;3

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Schmücker, Malte, Jørgen Haraszuk, Per Hölmich, and Kristoffer W. Barfod. "Graft Failure, Revision ACLR, and Reoperation Rates After ACLR With Quadriceps Tendon Versus Hamstring Tendon Autografts: A Registry Study With Review of 475 Patients." American Journal of Sports Medicine 49, no. 8 (2021): 2136–43. http://dx.doi.org/10.1177/03635465211015172.

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Background: It has been indicated that anterior cruciate ligament reconstruction (ACLR) with a quadriceps tendon (QT) graft has a higher risk of revision compared with ACLR performed with a hamstring tendon (HT) graft. Purpose/Hypothesis: To investigate whether ACLR with QT graft had a higher risk of graft failure, revision ACLR, or reoperation compared with HT graft in a high-volume center. We hypothesized that there would be no between-group differences. Study Design: Cohort study; Level of evidence, 3. Methods: This was a registry study with review of medical records. Our study cohort consi

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Heida, Annejet, Lisette J. M. E. van der Does, Ahmed A. Y. Ragab, and Natasja M. S. de Groot. "A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6." Case Reports in Medicine 2019 (June 20, 2019): 1–4. http://dx.doi.org/10.1155/2019/1384139.

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We report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene). During hospitalization, prolonged QTc intervals and frequent episodes of ventricular tachyarrhythmias manifested. Genetic testing identified a mutation of the KCNH2 gene and an unclassified variant, most likely pathogenic, of the KCNE2 gene. This digenic inheritance is extremely rare.

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Hunnicutt, Jennifer L., Chris M. Gregory, Michelle M. McLeod, Shane K. Woolf, Russell W. Chapin, and Harris S. Slone. "Quadriceps Recovery After Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Versus Patellar Tendon Autografts." Orthopaedic Journal of Sports Medicine 7, no. 4 (2019): 232596711983978. http://dx.doi.org/10.1177/2325967119839786.

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Background: Quadriceps tendon (QT) autografts are being increasingly used for anterior cruciate ligament reconstruction (ACLR). A paucity of studies exist that compare QT autografts with alternative graft options. Additionally, concerns exist regarding quadriceps recovery after graft harvest insult to the quadriceps muscle-tendon unit. Purpose/Hypothesis: The purpose of this study was to compare quadriceps recovery and functional outcomes in patients with QT versus bone–patellar tendon–bone (BPTB) autografts. The hypothesis was that those with QT autografts would demonstrate superior outcomes.

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Namgung, June. "Electrocardiographic Findings in Takotsubo Cardiomyopathy: ECG Evolution and Its Difference from the ECG of Acute Coronary Syndrome." Clinical Medicine Insights: Cardiology 8 (January 2014): CMC.S14086. http://dx.doi.org/10.4137/cmc.s14086.

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Background Electrocardiogram (ECG) manifestations of takotsubo cardiomyopathy (TC) produce ST-segment elevation or T-wave inversion, mimicking acute coronary syndrome (ACS). We describe the ECG manifestation of TC, including ECG evolution, and its different points from ACS. Methods We studied 37 consecutive patients (age 67 ± 15 years, range 23-89, M:F = 12:25) from March 2004 to November 2012 with a diagnosis of TC who were proven to have apical ballooning on echocardiography or left ventricular angiography and normal coronary artery. We analyzed their standard 12-lead ECGs, including rate, P

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Chernoby, Katie, Michael F. Lucey, Carrie L. Hartner, Michelle Dehoorne, and Stephanie B. Edwin. "Impact of a clinical decision support tool targeting QT-prolonging medications." American Journal of Health-System Pharmacy 77, Supplement_4 (2020): S111—S117. http://dx.doi.org/10.1093/ajhp/zxaa269.

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Abstract Purpose To evaluate the impact of a newly implemented clinical decision support (CDS) tool targeting QT interval–prolonging medications on order verification and provider interventions. Methods A multicenter, retrospective quasi-experimental study was conducted to evaluate provider response to CDS alerts triggered during ordering of QT-prolonging medications for adult patients. The primary outcome was the proportion of orders triggering QTc alerts that were continued without intervention during a specified preimplementation phase (n = 49) and during a postimplementation phase (n = 100

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Колоцей, Л. В. "Association of Endothelial NO-Syntase Gene C786T Polymorphism with the Development of Drug-Induced Long QT Interval Syndrome Caused by Class III Antiarrhythmic Drugs." Рецепт, no. 4 (September 13, 2022): 542–55. http://dx.doi.org/10.34883/pi.2022.25.4.020.

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Цель. Установить взаимосвязь полиморфизма С786T гена эндотелиальной синтазы оксида азота (NOS3) с электрокардиографическими показателями реполяризации желудочков, а также риском развития лекарственно-индуцированного синдрома удлиненного интервала QT (СУИ QT) и неустойчивой полиморфной желудочковой тахикардии (ЖТ) на фоне приема антиаритмических препаратов III класса.Материалы и методы. В исследование включено 92 пациента: из них 75 (основная группа) – с ишемической болезнью сердца (ИБС) и/или артериальной гипертензией (АГ) и нарушениями ритма сердца, принимавших антиаритмические препараты III

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Jumahat, Shaliza, Gan Kok Beng, Norbahiah Misran, Mohammad Tariqul Islam, Nurhafizah Mahri, and Mohd Hasni Ja’afar. "Automated QT Interval Measurement Using Modified Pan-Tompkins Algorithm with Independent Isoelectric Line Approach." Journal of Biomimetics, Biomaterials and Biomedical Engineering 44 (February 2020): 51–61. http://dx.doi.org/10.4028/www.scientific.net/jbbbe.44.51.

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The QT interval on the electrocardiogram (ECG) signal is known to have an important role in monitoring heart’s electrical activity because the presence of QT interval prolongation can be associated with life-threatening cardiac events. This interval can be identified and measured using either manual or automated techniques. Currently, studies on automated QT interval measurement algorithms are becoming a growing field, as they can provide the best solution to overcome misdiagnosis and timely issues resulting from manual identification. However, the physiological variability of the QRS complex

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Pizzuto, Matthew F., Gen Suzuki, Michael D. Banas, Brendan Heavey, James A. Fallavollita, and John M. Canty. "Dissociation of hemodynamic and electrocardiographic indexes of myocardial ischemia in pigs with hibernating myocardium and sudden cardiac death." American Journal of Physiology-Heart and Circulatory Physiology 304, no. 12 (2013): H1697—H1707. http://dx.doi.org/10.1152/ajpheart.00166.2013.

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Many survivors of sudden cardiac death (SCD) have normal global ventricular function and severe coronary artery disease but no evidence of symptomatic ischemia or infarction before the development of lethal ventricular arrhythmias, and the trigger for ventricular tachycardia (VT)/ventricular fibrillation (VF) remains unclear. We sought to identify the role of spontaneous ischemia and temporal hemodynamic factors preceding SCD using continuous telemetry of left ventricular (LV) pressure and the ECG for periods up to 5 mo in swine ( n = 37) with hibernating myocardium who experience spontaneous

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McPate, Mark J., Rona S. Duncan, James T. Milnes, Harry J. Witchel, and Jules C. Hancox. "The N588K-HERG K+ channel mutation in the ‘short QT syndrome’: Mechanism of gain-in-function determined at 37°C." Biochemical and Biophysical Research Communications 334, no. 2 (2005): 441–49. http://dx.doi.org/10.1016/j.bbrc.2005.06.112.

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Ouwehand, Willem Hendrik, and Nicole Soranzo. "Functional Genomics Approaches to Platelet Signaling." Blood 116, no. 21 (2010): SCI—37—SCI—37. http://dx.doi.org/10.1182/blood.v116.21.sci-37.sci-37.

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Abstract Abstract SCI-37 The count, volume and function of platelets varies in the population and there is ample evidence that all 3 quantitative traits (QT) are highly heritable. The control of platelet function is complex with a large number of forward and reverse regulatory pathways that promote and inhibit thrombus formation, respectively. We used 4 parallel genomics approaches with the aim to identify novel regulators of platelet function. First we established a genome-wide expression (GWE) HaemAtlas of all 8 haematological elements, including erythroblasts and megakaryocytes (MKs)(1). Mi

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Mistry, Sejal, Ramkiran Gouripeddi, Candace M. Reno, Samir Abdelrahman, Simon J. Fisher, and Julio C. Facelli. "Detecting hypoglycemia-induced electrocardiogram changes in a rodent model of type 1 diabetes using shape-based clustering." PLOS ONE 18, no. 5 (2023): e0284622. http://dx.doi.org/10.1371/journal.pone.0284622.

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Sudden death related to hypoglycemia is thought to be due to cardiac arrhythmias. A clearer understanding of the cardiac changes associated with hypoglycemia is needed to reduce mortality. The objective of this work was to identify distinct patterns of electrocardiogram heartbeat changes that correlated with glycemic level, diabetes status, and mortality using a rodent model. Electrocardiogram and glucose measurements were collected from 54 diabetic and 37 non-diabetic rats undergoing insulin-induced hypoglycemic clamps. Shape-based unsupervised clustering was performed to identify distinct cl

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Isbister, Geoffrey K., and Corrine R. Balit. "Bupropion Overdose: QTc Prolongation and its Clinical Significance." Annals of Pharmacotherapy 37, no. 7-8 (2003): 999–1002. http://dx.doi.org/10.1345/aph.1c481.

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OBJECTIVE: To investigate the cardiotoxicity of bupropion hydrochloride in deliberate self-poisoning. METHODS: A prospective study was conducted in a national poisons information center (PIC) of cases of adult deliberate self-poisoning with medical record follow-up of the patients. Fifty-nine cases of bupropion deliberate self-poisoning managed in the hospital, in which the New South Wales PIC was contacted for advice, were evaluated from November 2000 through July 2001. Clinical effects and electrocardiographic (ECG) parameters (QRS, QT, QTc) were the main outcome measures. RESULTS: ECGs were

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Cheney, F. W., M. J. Bishop, B. L. Eisenstein, and L. D. Artman. "Hypoxic pulmonary vasoconstriction does not affect hydrostatic pulmonary edema formation." Journal of Applied Physiology 62, no. 2 (1987): 776–80. http://dx.doi.org/10.1152/jappl.1987.62.2.776.

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We studied the effects of regional hypoxic pulmonary vasoconstriction (HPV) on lobar flow diversion in the presence of hydrostatic pulmonary edema. Ten anesthetized dogs with the left lower lobe (LLL) suspended in a net for continuous weighing were ventilated with a bronchial divider so the LLL could be ventilated with either 100% O2 or a hypoxic gas mixture (90% N2–5% CO2–5% O2). A balloon was inflated in the left atrium until hydrostatic pulmonary edema occurred, as evidenced by a continuous increase in LLL weight. Left lower lobe flow (QLLL) was measured by electromagnetic flow meter and ca

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Karhan, Asuman N., Hayrettin H. Aykan, Ersin Gümüş, et al. "Assessment of cardiac function and electrocardiographic findings in patients with Wilson’s disease." Cardiology in the Young 29, no. 09 (2019): 1183–88. http://dx.doi.org/10.1017/s104795111900180x.

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AbstractBackground:This study evaluated cardiac function using tissue Doppler echocardiography and assessed electrocardiographic findings in children diagnosed with Wilson’s disease.Method:Asymptomatic patients with a diagnosis of Wilson’s disease (n = 43) were compared to healthy controls (n = 37) that were age and gender matched.Results:The standard electrocardiographic and conventional echocardiographic examinations were similar in both groups. The left ventricular ejection fraction, shortening fraction, and diastolic function were not significantly different between the two groups. The Tei

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Cortes, Jorge E., Hagop Kantarjian, James M. Foran, et al. "Phase I Study of Quizartinib Administered Daily to Patients With Relapsed or Refractory Acute Myeloid Leukemia Irrespective of FMS-Like Tyrosine Kinase 3–Internal Tandem Duplication Status." Journal of Clinical Oncology 31, no. 29 (2013): 3681–87. http://dx.doi.org/10.1200/jco.2013.48.8783.

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Purpose FMS-like tyrosine kinase 3–internal tandem duplication (FLT3-ITD) mutations in acute myeloid leukemia (AML) are associated with early relapse and poor survival. Quizartinib potently and selectively inhibits FLT3 kinase activity in preclinical AML models. Patients and Methods Quizartinib was administered orally at escalating doses of 12 to 450 mg/day to 76 patients (median age, 60 years; range, 23 to 86 years; with a median of three prior therapies [range, 0 to 12 therapies]), enrolled irrespective of FLT3-ITD mutation status in a phase I, first-in-human study in relapsed or refractory

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Mellor, Greg J., Pankaj Panwar, Andrea K. Lee, et al. "Type 8 long QT syndrome: pathogenic variants in CACNA1C-encoded Cav1.2 cluster in STAC protein binding site." EP Europace 21, no. 11 (2019): 1725–32. http://dx.doi.org/10.1093/europace/euz215.

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Abstract Aims Pathogenic gain-of-function variants in CACAN1C cause type-8 long QT syndrome (LQT8). We sought to describe the electrocardiographic features in LQT8 and utilize molecular modelling to gain mechanistic insights into its genetic culprits. Methods and results Rare variants in CACNA1C were identified from genetic testing laboratories. Treating physicians provided clinical information. Variant pathogenicity was independently assessed according to recent guidelines. Pathogenic (P) and likely pathogenic (LP) variants were mapped onto a 3D modelled structure of the Cav1.2 protein. Nine

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Sergeev, E. A., B. I. Geltser, S. M. Kh Said Shokh, V. N. Kotelnikov, and E. V. Markelova. "Assessment of indicators of pulmonary volemia and systemic inflammatory response in patients with comorbidity of chronic obstructive pulmonary disease and ischemic heart disease after coronary artery bypass grafting." Bulletin Physiology and Pathology of Respiration, no. 80 (July 16, 2021): 8–17. http://dx.doi.org/10.36604/1998-5029-2021-80-8-17.

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Inroduction. Systemic inflammatory response (SIR) is an obligatory manifestation of operational stress affecting the functional status of patients, which is important to consider in persons with comorbid pathology.Aim. Evaluation of the relationship between pulmonary volemia and SIR indicators in patients with comorbidity of chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) after coronary artery bypass grafting (CABG).Materials and methods. The study included 76 IHD patients aged 53 to 77 years who underwent CABG. Among the surveyed, 2 groups were identified: 39 pat

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Çetin, Mecnun, İbrahim H. Yavuz, Mehmet Gümüştaş, and Göknur Ö. Yavuz. "P wave dispersion, Tpeak–Tend interval, and Tp-e/QT ratio in children with psoriasis." Cardiology in the Young 30, no. 3 (2020): 318–22. http://dx.doi.org/10.1017/s1047951119002968.

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AbstractBackground:Psoriasis is a chronic inflammatory, multi-system disease that often begins in childhood and characterised by inflammatory skin, nails, scalp, and joint manifestations. The inflammation in psoriasis may promote some effect on the cardiac conduction system.Objective:The aim of this study is to investigate myocardial repolarisation anomaly on the conducting system in the paediatric psoriasis using P wave dispersion, Tpeak–Tend interval, and Tp-e/QT ratio.Methods:Forty-two patients diagnosed with psoriasis and 37 age- and sex-matched healthy children were enrolled in the study.

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Dietrichs, Erik S., Karen McGlynn, Andrew Allan, et al. "Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology." Cardiovascular Research 116, no. 13 (2020): 2081–90. http://dx.doi.org/10.1093/cvr/cvz309.

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Abstract Aims Treatment of arrhythmias evoked by hypothermia/rewarming remains challenging, and the underlying mechanisms are unclear. This in vitro experimental study assessed cardiac electrophysiology in isolated rabbit hearts at temperatures occurring in therapeutic and accidental hypothermia. Methods and results Detailed ECG, surface electrogram, and panoramic optical mapping were performed in isolated rabbit hearts cooled to moderate (31°C) and severe (17°C) hypothermia. Ventricular activation was unchanged at 31°C while action potential duration (APD) was significantly prolonged (176.9 ±

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Loukrakpam, Bidyarani, Laishram Geetanjali, O. Puinabati Luikham, and Sanjoy K. Shylla. "Electrocardiographic changes in patients with pre-eclampsia." Annals of Medical Physiology 3, no. 1 (2019): 10–13. http://dx.doi.org/10.23921/amp.2019v3i1.26774.

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Pre-eclampsia is a hypertensive disorder of pregnancy that is associated with elevated maternal risk for cardiovascular disease. Electrocardiographic (ECG) changes in pre-eclampsia have been documented in some studies. Electrocardiography has recently emerged as a useful tool to evaluate cardiovascular complication during and after pregnancy. The present study was therefore undertaken to find out electrocardiographic changes in pre-eclamptic women, visiting Regional Institute of Medical Sciences, Manipur. The aim of this study was to determine the electrocardiographic changes in both pre-eclam

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Hohnloser, Stefan H., Frank Baedeker, and Andreas van de Loo. "911-37 Quinidine or Sotalol-induced Changes in QT-Dispersion During Pharmacological Conversion Therapy of Atrial Fibrillation: Link to Proarrhythmia as Assessed in a Prospective, andomized Trial." Journal of the American College of Cardiology 25, no. 2 (1995): 66A. http://dx.doi.org/10.1016/0735-1097(95)91726-e.

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Gligic, Branko, Radoslav Romanovic, Goran Radjen, Dragan Tavciovski, Predrag Djuran, and Slobodan Obradovic. "Relationship between QT dispersion and reperfusion in the acute myocardial infarction." Vojnosanitetski pregled 60, no. 1 (2003): 19–27. http://dx.doi.org/10.2298/vsp0301019g.

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Background. QT dispersion (QTd) represents the parameter of the expanded heterogeneity of myocard of ventricles. The aim of this study was to examine the dynamics of changes of QTd during the first 5 days of the acute myocardial infarction (AMI) in dependence to noninvasively estimated success of thrombolytic therapy. Methods. Thirty six patients with AMI were included in the study. All patients were treated with alteplaze according to rapid protocol. QTd (QTc max-QTc min) was measured immediately after the reception (0 min), after the thrombolytic therapy (90 min) and since the 2nd to the 5th

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Roozen, Geert V. T., Ruchika Meel, Joyce Peper, et al. "Electrocardiographic and echocardiographic abnormalities in urban African people living with HIV in South Africa." PLOS ONE 16, no. 2 (2021): e0244742. http://dx.doi.org/10.1371/journal.pone.0244742.

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Background Studies from high income countries report that HIV-positive people have an impaired systolic and diastolic cardiac function compared to HIV-negative people. It is unclear if results can be translated directly to the Sub-Saharan Africa context. This study assesses electro- and echocardiographic characteristics in an urban African population, comparing HIV-positive people (treated and not yet treated) with HIV-negative controls. Methods We conducted a cross-sectional study in Johannesburg, South Africa. We enrolled HIV-positive participants from three randomized controlled trials that

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Patel, Salma, Wojciech Zareba, Raymond Woosley, et al. "0441 Positive airway pressure therapy associated changes in ventricular repolarization in patients with heart failure." SLEEP 46, Supplement_1 (2023): A196. http://dx.doi.org/10.1093/sleep/zsad077.0441.

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Abstract Introduction Obstructive sleep apnea (OSA) is associated with prolonged ventricular repolarization at baseline that further increases during sleep when an apnea/hypopnea event occurs. Aggressive treatment of OSA with positive airway pressure therapy (PAP) may further prolong ventricular repolarization during apnea/hypopnea events particularly in patients with heart failure (HF). The goal of this study was to evaluate how ventricular repolarization changes during apnea/hypopnea events in patients with heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction and in tho

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Dagradi, Federica, Carla Spazzolini, Silvia Castelletti, et al. "Exercise Training-Induced Repolarization Abnormalities Masquerading as Congenital Long QT Syndrome." Circulation 142, no. 25 (2020): 2405–15. http://dx.doi.org/10.1161/circulationaha.120.048916.

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Background: The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were making occasional diagnostic errors by considering as affected subjects who, over time, resulted as not affected. These individuals were all actively practicing sports—an observation that helped in the design of our study. Methods: We focused on subjects referred to our center by sports medicine doctors on suspicion of LQTS because of marked repolarization abnormalities on the ECG performed during the mandatory medical visit necessary in

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Tran, Phu N., Jiansong Sheng, Aaron L. Randolph, et al. "Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block." PLOS ONE 15, no. 11 (2020): e0241362. http://dx.doi.org/10.1371/journal.pone.0241362.

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Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction. QTC prolongation that crosses the 10 msec threshold of regulatory concern was observed at a supratherapeutic dose in two thorough QT studies for the transdermal buprenorphine product BUTRANS®. Because QTC prolongation can be associated with Torsades de Pointes (TdP), a rare but potentially fatal ventricular arrhythmia, these results have led to further investigation of the electrophysiological effects of buprenorphine. Drug-induced QTC prolongation and TdP are most commonly caused by acute inhibition

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Chistyakova, M. V., and A. V. Govorin. "FEATURES OF HEART LESIONS IN PATIENTS WITH VIRAL LIVER CIRRHOSIS." Rational Pharmacotherapy in Cardiology 14, no. 3 (2018): 387–92. http://dx.doi.org/10.20996/1819-6446-2018-14-3-387-392.

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Aim. To study the structural and functional parameters of the heart, as well as the effect of antiviral therapy on certain cardiohemodynamic parameters in patients with viral liver cirrhosis (VLC).Material and methods. 96 patients with VLC (median age 42.1 [36;44] years, median duration of the disease – 3.5 [2.8;6.7] years) were examined. Patients without ascites (n=59) were included into the 1st group, and patients with ascites (n=37) – into the 2nd group. The control group included 21 healthy volunteers. Standard and tissue echocardiography, Holter monitoring of electrocardiogram were perfor

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Zhang, Yanmin, Xiaomin Li, Ying Yang, Jie Wang, Xinru Gao, and Mengyun Fan. "The combined novel KCNQ1 frameshift I145Sfs*92 and nonsense W392X variants caused Jervell and Lange-Nielsen syndrome in a Chinese infant presenting with sustained foetal bradycardia." EP Europace 22, no. 12 (2020): 1880–84. http://dx.doi.org/10.1093/europace/euaa154.

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Abstract Aims We report clinical and molecular analysis of an infant presenting with foetal bradycardia and clinical outcome of Jervell and Lange-Nielsen syndrome (JLNS). Methods and results Clinical, electrocardiogram (ECG), and echocardiographic data were collected from members in a three-generation family. Whole exomes were amplified and sequenced for proband. The identified variants were verified in the remaining members. The pathogenicity of candidate variants was predicted using multiple software programmes. A 28-year-old non-consanguineous Chinese woman at 23 weeks’ gestation presenting

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Conte, Giulio, Daniel Scherr, Radoslaw Lenarczyk, et al. "Diagnosis, family screening, and treatment of inherited arrhythmogenic diseases in Europe: results of the European Heart Rhythm Association Survey." EP Europace 22, no. 12 (2020): 1904–10. http://dx.doi.org/10.1093/europace/euaa223.

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Abstract The spectrum of inherited arrhythmogenic diseases (IADs) includes disorders without overt structural abnormalities (i.e. primary inherited arrhythmia syndromes) and structural heart diseases (i.e. arrhythmogenic ventricular cardiomyopathy, hypertrophic cardiomyopathy). The aim of this European Heart Rhythm Association (EHRA) survey was to evaluate current clinical practice and adherence to 2015 European Society of Cardiology Guidelines regarding the management of patients with IADs. A 24-item centre-based online questionnaire was presented to the EHRA Research Network Centres and the

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Romero, Jose R., Alicia Rivera, Adriana Muñiz, Ronald Nagel, and Mary E. Fabry. "Arginine Diet for Sickle Transgenic Mice Reduces Endothelin-1-Stimulated Gardos Channel Activity." Blood 110, no. 11 (2007): 3399. http://dx.doi.org/10.1182/blood.v110.11.3399.3399.

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Abstract Arginine (ARG) supplementation (5% arginine in chow) restores plasma ARG levels in S+S-Antilles mice to that found in C57BL mice and is associated with a reduction in Ca++ activated K+ channel (Gardos channel) activity, MCHC and high density red cells (Romero, Blood 99(4):2002). However the mechanisms for these effects are not entirely clear. Endothelin-1 (ET) is a potent vasoconstrictor that has been shown to activate Gardos channel activity and reduce MCHC. We hypothesized that reduced ET could account for the decrease in Gardos channel activity. We report here that arginine diet re

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Real-Delor, Raúl E., Giovanni J. Pirelli-Cubas, Jorge L. Ortiz-Martínez, et al. "Frecuencia de prolongación del intervalo QTc en adultos infectados con VIH de Paraguay en 2020." Revista Peruana de Investigación en Salud 5, no. 3 (2021): 173–79. http://dx.doi.org/10.35839/repis.5.3.935.

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Introducción: el intervalo QTc prolongado predispone a arritmias graves. Diversos medicamentos, entre ellos los antirretrovirales, pueden prolongarlo. Los objetivos fueron determinar las características demográficas, clínicas y la frecuencia del intervalo QTc prolongado en pacientes con VIH. Métodos: estudio observacional, prospectivo, con grupo control. Se incluyeron varones y mujeres, mayores de 18 años, portadores de infección por VIH, que acudieron al Hospital Nacional (Itauguá, Paraguay) durante 2020. Actuaron como grupo control los estudiantes de Medicina. Se excluyeron todos los sujetos

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Di Veroli, Giovanni Y., Mark R. Davies, Henggui Zhang, Najah Abi-Gerges, and Mark R. Boyett. "High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment." American Journal of Physiology-Heart and Circulatory Physiology 304, no. 1 (2013): H104—H117. http://dx.doi.org/10.1152/ajpheart.00511.2012.

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The use of computational models to predict drug-induced changes in the action potential (AP) is a promising approach to reduce drug safety attrition but requires a better representation of more complex drug-target interactions to improve the quantitative prediction. The blockade of the human ether-a-go-go-related gene (HERG) channel is a major concern for QT prolongation and Torsade de Pointes risk. We aim to develop quantitative in-silico AP predictions based on a new electrophysiological protocol (suitable for high-throughput HERG screening) and mathematical modeling of ionic currents. Elect

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