Relevant bibliographies by topics / Pyridazinone

Academic literature on the topic 'Pyridazinone'

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Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Pyridazinone"

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Deeb, Ali, Besher Bayoumy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions." Zeitschrift für Naturforschung B 47, no. 3 (March 1, 1992): 418–23. http://dx.doi.org/10.1515/znb-1992-0320.

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Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, formamide and carbon disulphide to furnish the corresponding pyrimido[4',5' :4,5]furo[2,3-c]pyridazin-4(3 H)-one derivatives. The reaction of 1 with o-aminophenol gave 3,4-diphenyl-11-oxo-10,11-dihydro-12H -pyridazino[ 4',3' :4,5]pyrrolo[3,2-b][1,5]benzoxazepine.
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HUSAIN, Asif, Aftab AHMAD, Anil BHANDARI, and Veerma RAM. "ANTITUBERCULAR ACTIVITY OF SOME NEWER 6-PYRIDAZINONE DERIVATIVES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 19, no. 19 (December 20, 2011): 17–23. http://dx.doi.org/10.48141/sbjchem.v19.n19.2011.22_2011.pdf.

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Two series of 6-pyridazinone derivatives (17-30) were synthesized and evaluated for antitubercular activities against the Mycobacterium tuberculosis H37Rv strain. The results indicated that among the synthesized compounds, 5-( 4-hydroxy-3-methoxybenzyl}-3-phenyl-1,6-dihydro-6-pyridazinone (23) showed good antitubercular activity. Three more compounds, (18, 25 & 27) were significant in their antitubercular action. The present study reveals the antitubercular potential of 6-pyridazinones.
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Rodriguez, Christina, Rachel Kiriakopoulos, Lana K. Hiscock, Zachary Schroeder, and Louise N. Dawe. "Pyridazinones from maleic hydrazide: a new substrate for the Mitsunobu reaction." Canadian Journal of Chemistry 98, no. 6 (June 2020): 273–77. http://dx.doi.org/10.1139/cjc-2019-0474.

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Crystal engineered organic frameworks assembled using hydrogen bonding are known, and examples constructed from hydroxypyridine/pyridone as the dominant source of hydrogen bonding have been reported. Less explored are analogous systems based on maleic hydrazide. Herein, a two-step route (Mitsunobu followed by Schiff base reactions) to asymmetrically substituted pyridazinones from maleic hydrazide (step 1) is reported with 2-, 3-, or 4-pyridinecarboxaldehyde (step 2). Upon reaction with 4-pyridinecarboxaldehyde, single crystals suitable for analysis via X-ray diffraction were obtained. Careful examination of this solid state structure and comparison with a large number of related structures in the Cambridge Structural Database revealed a pyridazinone (vs. pyridazinol) core and persistent [Formula: see text] “head-to-tail” hydrogen bonded dimers. Although these pyridazinones were originally considered suitable for use as ligands for metal cation coordination, challenges in achieving this outcome were encountered.
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Rimaz, Mehdi, Jabbar Khalafy, and Peyman Najafi Moghadam. "A Regioselective One-Pot, Three Component Synthesis of 6-Aryl-4-cyano-3(2H)-pyridazinones in Water." Australian Journal of Chemistry 63, no. 9 (2010): 1396. http://dx.doi.org/10.1071/ch09602.

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A series of 4-cyano-3(2H)-pyridazinones bearing different aryl substituents in the 6-position of the pyridazinone ring was synthesized regioselectively using a novel efficient one-pot three component reaction of alkyl 2-cyanoacetates with arylglyoxals in the presence of hydrazine hydrate at room temperature in water.
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Asif, Mohammad. "Some Conventional and Convenient Process for Functionalization of 6-Phenyl-4,5-Dihydropyridazinone Compounds." Asian Journal of Chemistry and Pharmaceutical Sciences 1, no. 1 (November 21, 2016): 41. http://dx.doi.org/10.18311/ajcps/2016/8375.

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The pyridazinone derivatives, particularly those bearing substituted different group or atom at a different position, have attracted considerable attention due to their characteristic pharmacological and other anticipated activities. These activities promoted the synthesis of a large number of substituted pyridazinone derivatives in order to explore the usefulness of this heterocyclic system. In the present review, various synthetic methods have been studied for the synthesis of substituted pyridazinone derivatives. The behaviour of the pyridazinone toward formaldehyde/piperidine, ethyl chloroacetate, chloroacetic acid, benzene sulfonyl chloride, bromine/acetic acid and aromatic aldehydes has also been studied. However, the reactions of the chloro derivative resulting from the reaction of pyridazinone with phosphorus oxychloride (POCl<sub>3</sub>). The behavior of chloropyridazine toward hydrazines, thiourea, sodium azide, anthranilic acid, aromatic amines and sulfa compounds have also been taken into consideration. Thethiopyridazinone derivativeswere prepared from the reaction of pyridazinone with phosphorus pentasulphide (P<sub>2</sub>S<sub>5</sub>). All the structures of were established on the based of spectroscopic data.<p> </p><p><strong> </strong></p>
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Widell, Karl-Olof, Christer Sundqvist, and Hemming I. Virgin. "Characterization of SAN 9789-Stimulated Lettuce (Lactuca sativa) Seed Germination." Weed Science 33, no. 2 (March 1985): 160–64. http://dx.doi.org/10.1017/s0043174500082023.

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Dark germination of light-requiring lettuce seeds (Lactuca sativaL. ‘Grand Rapids’) was stimulated by SAN 9789 [4-chloro-5-(methylamino-2-(α,α,α-trifluoro-m-tolyl)-3(2H)-pyridazinone] and to a minor degree by BASF 13761 [4-chloro-5-methoxy-2-phenyl-3(2H)-pyridazinone] and BASF 44521 [4-chloro-5-methoxy-2-(α,α,α-trifluoro-m-tolyl)-3(2H)-pyridazinone], but not by’ pyrazon [5-amino-4-chloro-2-phenyl-3(2H)-pyridazinone], SAN 9785 [4-chloro-5-(dimethylamino)-2-phenyl-3 (2H)-pyridazinone], SAN 9774 [5-amino-4-chloro-2-(α,α,α-trifluoro-m-tolyl)-3(2H)-pyridazinone], or SAN 6706 [4-chloro-5-(dimethylamino)-2-(α,α,α-trifluoro-m-tolyl)-3(2H)-pyridazinone]. SAN 9789 stimulation was inhibited by cis-4-cyclohexene-1,2-dicarboximide (CHDC), and abscisic acid (ABA) at 1 × 10-4M. Red light nullified the inhibitory effect of CHDC (1 × 10-4M) but not the inhibitory effect of ABA (1 × 10-4M) on SAN 9789 stimulated germination. Gibberellic acid (GA3) and kinetin (6-furfurylaminopurine) increased the germination stimulatory effect of SAN 9789 in darkness. Temperatures above 25 C decreased the effect of SAN 9789, with a temperature of 35 C completely inhibiting germination. The inhibitory effect of CHDC was strongly decreased at temperatures below 20 C. SAN 9789-induced germination in darkness was always the same (25 to 26% units increase in germination) even though the red light-stimulated germination differed with the seed batch.
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Li, Hong Sen, Lin Jing Zhao, Jia Rong Tang, Yi Zhe Cheng, Jie Chen, Zhi Yi Zheng, and Hai Lin Sun. "Study on New 3-(2H)-Pyridazinones Derivtives." Advanced Materials Research 524-527 (May 2012): 1751–54. http://dx.doi.org/10.4028/www.scientific.net/amr.524-527.1751.

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A series of novel pyridazinone derivatives was designed and synthesized. Insecticide activities of 7 pyridazinone derivatives were evaluated. The Preliminary bioassy test showed that compounds exhibited mild activity or moderate activity against Oriental armyworm at 200mg L-1
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El Kalai, Fouad, Cemile Baydere, Said Daoui, Rafik Saddik, Necmi Dege, Khalid Karrouchi, and Noureddine Benchat. "Crystal structure and Hirshfeld surface analysis of ethyl 2-[5-(3-chlorobenzyl)-6-oxo-3-phenyl-1,6-dihydropyridazin-1-yl]acetate." Acta Crystallographica Section E Crystallographic Communications 75, no. 6 (May 24, 2019): 892–95. http://dx.doi.org/10.1107/s2056989019007424.

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The title pyridazinone derivative, C21H19ClN2O3, is not planar. The unsubstituted phenyl ring and the pyridazine ring are inclined to each other, making a dihedral angle of 17.41 (13)° whereas the Cl-substituted phenyl ring is nearly orthogonal to the pyridazine ring [88.19 (13)°]. In the crystal, C—H...O hydrogen bonds generate dimers with R 2 2(10) and R 2 2(24) ring motifs which are linked by C—H...O interactions, forming chains extending parallel to the c-axis direction. The intermolecular interactions were investigated using Hirshfeld surface analysis and two-dimensional fingerprint plots, revealing that the most significant contributions to the crystal packing are from H...H (44.5%), C...H/H...C (18.5%), H...O/H...O (15.6%), Cl...H/H...Cl (10.6%) and C...C (2.8%) contacts.
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Wasfy, Ashraf A. F., Mohamed M. H. Arief, Mahassen S. Amine, Shafey G. Donia, and Aly A. Aly. "γ-Oxo Carboxylic Acids in Heterocyclic Synthesis, III. Synthesis of Biologically Active 4-Benzylamino-6-(5,5-dioxodibenzothiophen- 2-yl)-2,3,4,5-tetrahydropyridazin-3-ones." Zeitschrift für Naturforschung B 57, no. 6 (June 1, 2002): 668–76. http://dx.doi.org/10.1515/znb-2002-0613.

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α-Benzylamino-β-(5,5-dioxodibenzothiophen-2-carbonyl)propionic acid (1) has been synthesized by treating the corresponding β-aroylacrylic acid with benzylamine in dry benzene. On treatment with hydrazine hydrate the keto acid 1 furnishes the corresponding pyridazinone derivative 2. The behaviour of 2 towards carbon electrophiles, namely, ethyl chloroacetate, acrylonitrile, formaldehyde and secondary amines (under Mannich reaction conditions), aromatic aldehydes and carbon nucleophiles, namely, POCl3/PCl3 and P2S5 has been investigated. The 3-chloropyridazine derivative 13 reacts with hydrazine hydrate to give the 3-hydrazino derivative 14. On treatment with ethyl acetoacetate and/or acetylacetone the hydrazine 14 undergoes cyclization to afford pyrazolone derivative 16 and 3-(3,5-dimethylpyrazol- 1-yl)pyridazine derivative 17, respectively. On reaction with acetylhydrazine in boiling butanol and/or sodium azide in DMF the 3-chloropyridazine derivative 13 affords the triazolo[4,3-b]pyridazine 18 and the tetrazolo[1,5-b]pyridazine 19, respectively. The anti-microbial activity of the synthesized derivatives has been investigated.
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Costas-Lago, María Carmen, Tamara Costas, Noemí Vila, and Pedro Besada. "4-[(tert-Butyldiphenylsilyloxy)methyl]pyridazin-3(2H)-one." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (November 30, 2013): o1859—o1860. http://dx.doi.org/10.1107/s1600536813032212.

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In the title compound, C21H24N2O2Si, the carbonyl group of the heterocyclic ring and the O atom of the silyl ether group are placed toward opposite sides and thetert-butyl and pyridazinone moieties areanti-oriented across the Si—O bond [torsion angle = −168.44 (19)°]. In the crystal, molecules are assembled into inversion dimers through co-operative N—H...O hydrogen bonds between the NH groups and O atoms of the pyridazinone rings of neighbouring molecules. The dimers are linked by π–π interactions involving adjacent pyridazinone rings [centroid–centroid distance = 3.8095 (19) Å], generating ladder-like chains along theb-axis direction. The chains are further linked into a two-dimensional network parallel to theabplane through weak C—H...π interactions.
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Dissertations / Theses on the topic "Pyridazinone"

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Greenwood, Jeremy R. (Jeremy Robert) 1971. "Pyridazinediones and amino acid receptors theoretical studies, design, synthesis and evaluation of novel analogues." [Sydney : J. Greenwood], 1999. http://www.pharmacol.usyd.edu.au/thesis.

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Title from title screen. Interactive three dimensional molecular data and multiple colour images. Text presented in Hypertext Markup Language (.htm); images in standard formats (.jpg, .gif); molecules presented mostly as Cambridge Protein Data Bank format (.pdb); some molecules presented in alternative X.Mol cartesian co-ordinates format (.xyz); search facility in PERL script. Includes bibliographical references. Text, numeric and representational data System requirements: for text, any standard web browser on any platform, Netscape 2.x or higher, Internet Explorer 3.x or higher; for molecular structures, viewer such as Rasmol or preferably MDL's Chemscape Chime; for search facility , an appropriately configured web server. Links to all required software for browsing on various platforms are included in the software directory in the thesis. Mode of access: World Wide Web.
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Greenwood, Jeremy Robert. "Pyridazinediones and amino acid receptors: theoretical studies, design, synthesis, and evaluation of novel analogues." Thesis, The University of Sydney, 1999. http://hdl.handle.net/2123/394.

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http://www.pharmacol.usyd.edu.au/thesis This thesis is primarily concerned with a class of chemical compounds known as pyridazinediones, being 6-membered aromatic rings containing two adjacent nitrogen atoms (pyridazine), doubly substituted with oxygen. In particular, the work focuses on pyridazine-3,6-diones, derivatives of maleic hydrazide (1). Understanding of the chemistry of these compounds is extended, using theoretical and synthetic techniques. This thesis is also concerned with two very important classes of receptors which bind amino acids in the brain: firstly, the inhibitory GABA receptor, which binds g-aminobutyric acid (GABA) (2) in vivo, and for which muscimol (3) is an agonist of the GABAA subclass; secondly, Excitatory Amino Acid (EAA) receptors, which bind glutamate (4) in vivo, and in particular the AMPA subclass, for which (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) (5) is an agonist. The connection between pyridazinediones and amino acid receptors is the design, synthesis, and evaluation of structures based on pyridazinediones as potential GABA and EAA receptor ligands. Techniques of theoretical chemistry, molecular modelling, synthetic chemistry, and in vitro pharmacology are used to explore pyridazine-3,6-dione derivatives as ligands.
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Greenwood, Jeremy Robert. "Pyridazinediones and amino acid receptors: theoretical studies, design, synthesis, and evaluation of novel analogues." University of Sydney, Department of Pharmacology, 1999. http://hdl.handle.net/2123/394.

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http://www.pharmacol.usyd.edu.au/thesis This thesis is primarily concerned with a class of chemical compounds known as pyridazinediones, being 6-membered aromatic rings containing two adjacent nitrogen atoms (pyridazine), doubly substituted with oxygen. In particular, the work focuses on pyridazine-3,6-diones, derivatives of maleic hydrazide (1). Understanding of the chemistry of these compounds is extended, using theoretical and synthetic techniques. This thesis is also concerned with two very important classes of receptors which bind amino acids in the brain: firstly, the inhibitory GABA receptor, which binds g-aminobutyric acid (GABA) (2) in vivo, and for which muscimol (3) is an agonist of the GABAA subclass; secondly, Excitatory Amino Acid (EAA) receptors, which bind glutamate (4) in vivo, and in particular the AMPA subclass, for which (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) (5) is an agonist. The connection between pyridazinediones and amino acid receptors is the design, synthesis, and evaluation of structures based on pyridazinediones as potential GABA and EAA receptor ligands. Techniques of theoretical chemistry, molecular modelling, synthetic chemistry, and in vitro pharmacology are used to explore pyridazine-3,6-dione derivatives as ligands.
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Moniot, Aurélie. "Etude des effets anti-inflammatoires et anti-cancéreux de nouvelles molécules agrosourcées à motif pyridazinone Synthesis and biological evaluation of pyridazinone derivatives as potential antiinflammatory agents Osteoinductive Material to Fine-Tune Paracrine Crosstalk of Mesenchymal Stem Cells With Endothelial Cells and Osteoblasts." Thesis, Reims, 2020. http://www.theses.fr/2020REIMS022.

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L’ostéosarcome est un cancer primitif rare de l’os dont les approches thérapeutiques actuelles sont encore malheureusement insuffisantes pour espérer une totale guérison, et pour lequel la recherche de nouvelles molécules efficaces est constante. De plus, après exérèse de la tumeur, le défaut généré peut nécessiter de recourir à des matériaux aidant la reconstruction osseuse. Or le potentiel inflammatoire de ces matériaux est bien documenté. Les inhibiteurs de phosphodiestérase de type 4, parmi lesquels des molécules à motif pyridazinone, ont d’ores et déjà fait leurs preuves en tant qu’agents anti-cancéreux et anti-inflammatoires dans un certain nombre de modèles cellulaires. L’objectif de ce travail a été d’évaluer les effets anti-cancéreux et anti-inflammatoires de nouvelles molécules à motif pyridazinone dérivant de précurseurs agrosourcées. Les effets anti-inflammatoires ont été validés sur la production cytokinique, le potentiel migratoire et le maintien des capacités phagocytaires des neutrophiles primaires humains in vitro et dans un modèle murin d’inflammation in vivo. Ces molécules ont également montré leur potentiel thérapeutique dans des modèles d’ostéosarcomes in vitro où elles sont en capacité de bloquer la prolifération et la migration cellulaire tout en induisant l’apoptose des cellules cancéreuses. In vivo ces molécules sont capables de ralentir la progression tumorale et de maintenir la qualité minérale osseuse. Les résultats obtenus indiquent que ces nouvelles molécules à motif pyridazinone pourraient s’intégrer dans des polythérapies pour leurs potentiels thérapeutiques à la fois anti-cancéreux et anti-inflammatoire
Osteosarcoma is a rare primary bone cancer for which current therapeutic approaches are unfortunately insufficient to provide a total cure. So the need for new molecules development is constant. In addition, after tumor excision, bone defect may require materials to fill and support bone rebuilding. The inflammatory potential of such materials is well documented. Phosphodiesterase type 4 inhibitors, including pyridazinone-scaffold based molecules, have already proven themselves as anti-cancer and anti-inflammatory agents in a number of in vitro models. The goal of this work was to assess the anti-cancer and anti-inflammatory effects of new pyridazinone-scaffold based molecules derived from agrosourced precursors. Anti-inflammatory effects have been assessed on cytokine production, migratory potential and the phagocytic abilities of human primary neutrophils in vitro and in an in vivo model of inflammation in mice. These molecules have also shown their therapeutic potential in in vitro osteosarcoma models where they decreased cell proliferation and migration while inducing apoptosis in cancer cells. In vivo, these molecules were able to decrease tumor growth and maintain mineral bone quality. These results indicated that new pyridazinone scaffold-based molecules might be integrated into a multi-therapy, both for their anti-cancer and anti-inflammatory therapeutic potential
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Goedhart, Christian Leonard. "Influence of osmotic stress, ethanol, and a substituted pyridazinone, BAS 13-338, on the growth and lipid composition of two Chlorella species." Diss., Virginia Polytechnic Institute and State University, 1987. http://hdl.handle.net/10919/53634.

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Chlorella vulgaris and Chlorella pyrenoidosa were compared relative to their abilities to grow at osmotic potentials of -0.1, -0.5, -1.0, -1.5, -2.0 MPa, [polyethylene glycol(PEG)-induced], and for osmotically-induced changes in lipid composition. C. vulgaris growth was inhibited as osmotic potentials decreased, while C. pyrenoidosa growth was moderately inhibited at -2.0 hPa. C. vulgaris produced increasing concentrations of triglycerides and sterol esters and decreasing levels of polar lipids and sterols as osmotic concentrations increased. Polar lipids, triglycerides, and sterols declined in C. pyrenoidosa while steryl esters remained constant. Ratios of free sterols to polar lipids were 10-fold greater in C. pyrenoidosa and were unaffected by reduced osmotic potentials. In C. vulgaris the sterol to polar lipid ratio declined. Decreasing osmotic potentials in a continuous culture of C. vulgaris, lowered cell lipid concentration, and had no effect on chlorophyll concentrations. The greatest decrease occurred as the osmotic potential decreased from -0.1 to -0.5 HPa. Decreasing osmotic potential caused the phospholipid concentrations to decline. Saturation of triglycerides and free fatty acids increased and decreased, respectively, while polar lipids remained fairly constant. However, the sterol to phospholipid ratio increased as the osmotic potential was lowered. BAS 13-338 (4-chloro-5-(dimethylamino)-2-phenyl-5- 3(2H)pyridazinone) had no effect on C. vulgaris resistance to osmotic stress, but caused growth inhibition as concentrations increased. However, BAS 13-338 was effective in decreasing growth inhibition of C. vulgaris grown in inhibitory levels of ethanol. BAS 13-338 had differing effects on the lipid composition of C. vulgaris when grown in PEG at an osmotic potential of -1.5 MPa compared to -0.1 MPa with 0.33% ethanol. The greatest effects were observed in the ethanol treatments where the qualitative composition of precursor sterols increased as the level of BAS 13-338 increased. This investigation confirmed the important role of lipids in responding to environmental stress through observations of lipid responses to osmotic stress and by manipulation of lipid concentrations using BAS 13-338. Resistance to ethanol inhibition but not osmotic inhibition was achieved in the investigation.
Ph. D.
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Byrichetti, Kiranmai. "Synthesis and Structure of a Substituted Pyridazine." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1080.

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Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that utilize organics as the semiconducting material. The synthesis of 5, 6-fused ring pyridazines beginning from fulvenes (Scheme 1) is described herein. These fused heterocycles will serve as synthetic models and building blocks for potential organic or organometallic conducting polymers. Our goal was to modify the route of Snyder et al. previously reported for the direct synthesis of pyridazine 2. This required improved synthesis of fulvene 1 and higher yields of 5. Additionally, a thorough analysis of the x-ray data was obtained to better understand the 3D aspects of this compound (pyridazine 2).This route was quite general and features an efficient and convenient synthesis. Single crystal X-ray analysis confirms the molecular structure of pyridazine 2. Full synthesis and characterization of newly formed pyridazine 2 and Fulvene 1 are reported.
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Guven, Alaettin. "Potentially tautomeric pyridazino(4, 5-b)indolones." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306148.

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Greenwood, Jeremy R. "Pyridazinediones and amino acid receptors theoretical studies, design, synthesis and evaluation of novel analogues /." [Sydney : J. Greenwood], 1999. http://www.pharmacol.usyd.edu.au/thesis.

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Thesis (Ph. D.)--Dept. of Pharmacology, University of Sydney, 1999.
Title from title screen. Interactive three dimensional molecular data and multiple colour images. Text presented in Hypertext Markup Language (.htm); images in standard formats (.jpg, .gif); molecules presented mostly as Cambridge Protein Data Bank format (.pdb); some molecules presented in alternative X. Mol cartesian co-ordinates format (.xyz); search facility in PERL script. Includes bibliographical references. A printed form was produced with limited features as a Faculty requirement; may also be issued in CD-ROM.
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Mernari, Bouchaïb. "Complexes binucléaires de dérivés de la pyridazyne ou du pyrazole : synthèses, structures cristallines et interactions magnétiques." Lille 1, 1987. http://www.theses.fr/1987LIL10015.

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Foster, Joshua B. "Development of Pyridazine-Derivatives for the Treatment of Neurological Disorders." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1545904228813231.

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Books on the topic "Pyridazinone"

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A, Graf Josef. Struktur-Funktionsbeziehungen zwischen Lipidmatrix und Pigment-Protein-Komplexen in Thylakoidmembranen: Physiologische und fluoreszenzspektroskopische Untersuchungen zur Wirkung von Pyridazinonen, Cytokininen und Cerulenin bei Petunia hybrida. Stuttgart: [Biologisches Institut der Universität Stuttgart], 1987.

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Güven, Alâettin. Potentially tautomeric pyridazino (4,5-b) indolones. Norwich: University of East Anglia, 1992.

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The pyridazines. New York: Wiley, 2000.

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Mayer, Michael. Farbe und Konstitution bei H-Chelaten der Pyrazinreihe: Präparative und spektroskopische Untersuchungen. Konstanz: Hartung-Gorre, 1985.

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The pyrazines. New York: John Wiley & Sons, 2002.

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Cinnolines and phthalazines: Supplement 2. Hoboken, N.J: Wiley, 2005.

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Taylor, Edward C., Peter Wipf, and Desmond J. Brown. Supplement 1, Pyridazines. Wiley-Interscience, 1999.

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Simpson, J. C. Pyridazine and Pyrazine Rings : (Cinnolines, Phthalazines, and Quinoxalines). Wiley & Sons, Incorporated, John, 2009.

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Simpson, J. C. Chemistry of Heterocyclic Compounds, Pyridazine and Pyrazine Rings. Wiley & Sons, Incorporated, John, 2008.

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Brown, D. J. Pyrazines, Volume 58, Supplement 1. Wiley & Sons, Incorporated, John, 2003.

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Book chapters on the topic "Pyridazinone"

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Fraker, Lesa D., Jennifer Van Eyk, and R. John Solaro. "Reversal of phosphate induced decreases in force by the benzimidazole pyridazinone, UD-CG 212 CL, in myofilaments from human ventricle." In The Cellular Basis of Cardiovascular Function in Health and Disease, 83–88. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-5765-4_11.

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Itai, Takanobu. "PyridazineN-Oxides." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 675–753. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch8.

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Demaison, J. "410 C4H4N2 Pyridazine." In Asymmetric Top Molecules. Part 2, 289. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_158.

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Joshi, Manoj K., Jack J. S. van Rensen, and Salil Bose. "4-Chloro-5-(Dimethyl Amino)-2-Phenyl-3-(2H)-Pyridazinone (San 9785) Induced Changes in the Structure and Function of Thylakoid Membranes of Pisum Sativum." In Research in Photosynthesis, 551–54. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-009-0383-8_120.

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Winkelmann, Jochen. "Self-diffusion coefficient of pyridazine." In Diffusion in Gases, Liquids and Electrolytes, 193. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-540-73735-3_102.

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Lenhert, Anne G., and Raymond N. Castle. "Pyridazine Aldehydes, Ketones, and Alcohols." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 353–406. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch4.

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Stevenson, Thomas M., Teodorica M. Cenizal, Eric A. Marshall, King Mo Sun, Andrew E. Taggi, Martin J. Currie, and Patrick L. Rardon. "4-Azolyl-5-Hydroxy Pyridazinones: Potent Grass Herbicides." In ACS Symposium Series, 305–15. Washington, DC: American Chemical Society, 2015. http://dx.doi.org/10.1021/bk-2015-1204.ch022.

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Horkel, Ernst. "Metalation of Pyridazine, Cinnoline, and Phthalazine." In Topics in Heterocyclic Chemistry, 223–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/7081_2012_97.

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Amoo, Victor E., Charles R. Harrison, George P. Lahm, Patrick D. Lowder, Thomas M. Stevenson, Jeffrey K. Long, Rafael Shapiro, et al. "Pyridazine Insecticides: Synthesis and Biological Activity." In ACS Symposium Series, 156–65. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2002-0800.ch015.

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Demaison, J. "401 C4H4ArN2 Pyridazine - argon (1/1)." In Asymmetric Top Molecules. Part 2, 274. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_149.

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Conference papers on the topic "Pyridazinone"

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El Rayes, Samir M. "Convenient Synthesis and Antimicrobial Activity of Some Novel Pyridazinone Bearing Triazole Moieties." In The 14th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2010. http://dx.doi.org/10.3390/ecsoc-14-00493.

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Mátyus, Péter, Olivér Éliás, Lázló Károlyházy, Géza Stájer, Veronika Harmath, and Orsolya Barabás. "Ring Closure Reactions of 4-Chloro-5-hydroxyalkylamino-6-nitro-3(2H)- pyridazinones: Synthesis of Novel Pyridazino-Fused Ring Systems." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01820.

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Salaheldin, Abdellatif, Lígia Rodrigues, and Ana Oliveira-Campos. "Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives." In The 11th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01319.

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Salim, Muath Bani, and Reza Nekovei. "Designing of PCBM Derivative using Pyridazine Compound for More Efficient Bulk Heterojunction Organic Solar Cell." In 2021 IEEE 48th Photovoltaic Specialists Conference (PVSC). IEEE, 2021. http://dx.doi.org/10.1109/pvsc43889.2021.9519059.

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Schnell, Barbara, and Thomas Kappe. "Rearrangement of Heterocycles via-2-oxoketenes: Synthesis and Rearrangement Reactions of Cross-Conjugated Mesomeric Pyridazino[2,3-a]pyrimidine." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01844.

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Franich, Andjela, Ivana Vasić, Snežana Rajković, Aleksandar Arsenijević, Marija Milovanović, Nebojša Arsenijević, Jelena Milovanović, and Marija Živković. "CYTOTOXICITY OF CATIONIC DINUCLEAR PLATINUM(II) COMPLEXES IN AN EXPERIMENTAL MODEL OF MOUSE COLON CANCER." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.293f.

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Abstract:
The series of nine dinuclear platinum(II) complexes, [{Pt(L)Cl}2(μ-X)]2+ (where L is two NH3 or bidentantly coordinated diamine ligand – ethylenediamine, en; (±)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(±)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2- dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd; (±)-1,3-pentanediamine,1,3-pnd, and X is a bridging pyrazine (pz) or pyridazine (pydz) ligand) have been synthesized and characterized. The antitumor potential of these complexes against CT26 cells were determined by in vitro and in vivo assays. A murine model of heterotopic colon cancer tumor was induced in immunocompetent BALB/c mice for investigating antitumor potential of the Pt(II) complexes in vivo. It was found that complexes Pt1, Pt2 and Pt7 shows significant in vitro cytotoxic activity against mouse colon carcinoma CT26 cells, while all these complexes show moderate apoptotic effect. Complexes Pt1 and Pt7 arrested CT26 cells in G2/M phase of cell cycle, while complexes Pt5 and Pt6 exerted the highest antiproliferative effect which was evaluated by detection of Ki67 expressing cells. Complexes Pt1 and Pt2 performed significant in vivo antitumor effects reducing the growth of primary tumor and the incidence of lung and liver metastases without causing the significant hepato- and nephro- toxicity.
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Tarby, Christine M., Liqi He, Brian E. Fink, Andrew Nation, Yufen Zhao, Soong-Hoon Kim, Libing Chen, et al. "Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5417.

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Spearman, P., S. Tavazzi, L. Silvestri, A. Burini, A. Borghesi, P. Mercandelli, M. Panigati, G. D'Alfonso, A. Sironi, and L. De Cola. "The role of molecular packing on the UV-visible optical properties of [Re 2 Cl 2 (CO) 6 4,5-(Me 3 Si) 2 pyridazine]." In SPIE Photonics Europe, edited by Barry P. Rand, Chihaya Adachi, and Volker van Elsbergen. SPIE, 2012. http://dx.doi.org/10.1117/12.922988.

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Troitskaya-Markova, Nadezhda, Olga Vlasova, and Oleg Rakitin. "4,5-DIOXO-4,5-DIHYDRO-4Λ4,5Λ4-BIS([1,2,5]OXADIAZOLO)[3,4-с:3',4'-e]PYRIDAZINE AS A SYNTHETIC EQUIVALENT OF 4,4'-DINITROSO-3,3'-BI(1,2,5-OXADIAZOLE)." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m779.aks-2019/305-307.

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Hosmane, Ramachandra, and Huan-Ming Chen. "Synthesis of 1-(2'-Deoxy-γ-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5 H,6H)-dion: a Potentially Beneficial Building Block for Antisense Applications." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01926.

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