Relevant bibliographies by topics / Pyridazine

Academic literature on the topic 'Pyridazine'

Author: Grafiati
Published: 4 June 2021
Last updated: 20 February 2023

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Journal articles on the topic "Pyridazine"

1

Deeb, Ali, Besher Bayoumy, Fathy Yasine, and Rida Fikry. "Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions." Zeitschrift für Naturforschung B 47, no. 3 (March 1, 1992): 418–23. http://dx.doi.org/10.1515/znb-1992-0320.

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Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, formamide and carbon disulphide to furnish the corresponding pyrimido[4',5' :4,5]furo[2,3-c]pyridazin-4(3 H)-one derivatives. The reaction of 1 with o-aminophenol gave 3,4-diphenyl-11-oxo-10,11-dihydro-12H -pyridazino[ 4',3' :4,5]pyrrolo[3,2-b][1,5]benzoxazepine.
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Barlin, GB. "Imidazo[1,2-B]Pyridazines. I. Some 3-Alkoxy-6-Halogeno-2-Phenyl-(and 4′-Substituted Phenyl)Imidazo[1,2-B]Pyridazines and 3-Methoxy-2,6-Diphenylimidazo[1,2-B]Pyridazine." Australian Journal of Chemistry 39, no. 11 (1986): 1803. http://dx.doi.org/10.1071/ch9861803.

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A series of 3-alkoxy-6-halogeno-2-phenyl(and 4′-substituted phenyl) imidazo [1,2-b] pyridazines (1) and 3-methoxy-2,6- diphenylimidazo [1,2-b] pyridazine have been prepared from the relevant pyridazin-3-amines and arylglyoxals, followed by O- alkylation of the corresponding imidazo [1,2-b]pyridazin-3(5H)-ones with diazoalkanes. 6- Chloro-3-methoxy-2-phenylimidazo[2,1-a] phthal-azine was prepared similarly.
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Barlin, GB, LP Davies, PW Harrison, NW Jacobsen, and AC Willis. "Imidazo[1,2-b]Pyridazines. XVI. Synthesis and Central Nervous System Activities of Some 6-(Chloro, Alkylthio, Phenylthio, Benzylthio or Pyridinylmethylthio)-3-(unsubstituted, benzamidomethyl or methoxy)-2-(styryl or benzoyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 47, no. 11 (1994): 1989. http://dx.doi.org/10.1071/ch9941989.

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Some 6-( chloro, alkylthio, phenylthio, benzylthio or pyridinylmethylthio )-3-( unsubstituted , benzamidomethyl or methoxy )-2-styrylimidazo[1,2-b] pyridazines and 6-chloro-3-( unsubstituted and benzamidomethyl )-2-benzoylimidazo[1,2-b] pyridazines have been prepared and tested for their ability to displace [3H]diazepam from rat brain plasma membranes. The structures of 6-chloro-2-benzoyl[and 6-fluoro-2-(4′-tolyl)] imidazo [1,2-b] pyridazine have been confirmed by X-ray analyses. The reactions of 6-methylthio(and 6-phenylthio)pyridazin-3-amines with 3-bromo-1-phenylpropane-1,2-dione also have been investigated. The 6-substituted 3-unsubstituted 2-styryl(and benzoyl ) imidazo [1,2-b] pyridazines did not bind strongly to rat brain benzodiazepine receptors; nor did the 3-benzamidomethyl or 3-methoxy derivatives (cf. the 2-phenyl analogues). However, 3-benzamidomethyl-6-(pyridin-3-ylmethylthio)-2-styrylimidazo[1,2-b] pyridazine was an exception with IC50 68 nM.
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M., Sumakanth, V. Malla Reddy, V. S. H. Krishnan, and B. S. Sastry. "Synthesis of Some New Imidazo[1,2-b] Pyridazines." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (May 31, 2009): 471–76. http://dx.doi.org/10.37285/ijpsn.2009.2.1.14.

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Several 2,6-diaryl-imidazo[1,2-b]pyridazines (5 & 7) were prepared from 3-amino-6-aryl-pyridazines (3) which in turn were obtained from the corresponding 6-aryl-pyridazine-3(2H)-ones(1) via., 6-aryl-pyridazin-3(2H)-thiones (2) as intermediates, by a reaction with an appropriate a-halocarbonyl compounds (4) or a-haloacyl carbamates (6) in a suitable solvent at reflux temperature. The resulted products were characterized by their physical, analytical and spectral data.
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Kazimierczuk, Zygmunt, Jarosław Kamiński, and Flavio Meggio. "Studies on Improved Synthesis of 2'-Deoxyribonucleosides of Pyridazine Derivatives." Collection of Czechoslovak Chemical Communications 71, no. 6 (2006): 889–98. http://dx.doi.org/10.1135/cccc20060889.

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A number of 2'-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly β-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloropyridazin-3-one and 6-chloro-2-(2'-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.
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Schmitt, Martine, Jean-Jacques Bourguignon, Gordon B. Barlin, and Les P. Davies. "Imidazo[1,2-b]pyridazines. XXIV Syntheses of Some 3-(Variously Substituted) Imidazo[1,2-b] pyridazines, 6-Substituted 2-Benzoyl- imidazo[1,2-b]pyridazines and Pyrimido[1,2-b]pyridazin- 5-ium-3-olates and their Interaction with Central and Mitochondrial Benzodiazepine Receptors." Australian Journal of Chemistry 50, no. 8 (1997): 779. http://dx.doi.org/10.1071/c97030.

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The syntheses of some ethyl 2-{2′-aryl-6′-(chloro, iodo and methoxy)imidazo[1,2-b]pyridazin-3′-yl}-2-(acetoxy, acylamino, hydroxy and methoxy)acetates, 6-methyl-2-(p-tolyl)- and 6-chloro-2-(4′-chlorophenyl)-3-trimethylammoniomethylimidazo[1,2-b]pyridazine iodides (and reactions thereof), 2-benzoyl 6-substituted imidazo[1,2-b]pyridazines and 7-(methoxy, chloro and phenylthio)-2-phenylpyrimido-[1,2-b]pyridazin-5-ium-3-olates are reported. The ability of these compounds to displace [3H]diazepam from rat forebrain membrane [central benzodiazepine receptor (BZR)] and rat kidney membrane [mitochondrial (peripheral-type) benzodiazepine receptor (PBR)] has been examined. The most active compound was ethyl 2-{6′-chloro-2′-(p-tolyl)imidazo[1,2-b]pyridazin-3′-yl}-2-hydroxyacetate with IC50 24 nM for displacement from the BZR and 91% displacement at 1000 nM from the PBR; the most selective for the PBR was 6-methyl-3-methylsulfonylmethyl-2-(p-tolyl)imidazo[1,2-b]pyridazine (PBR, IC50 92 nM; BZR, 15% inhibition of binding by [3H]diazepam at 1000 nM).
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Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XIV. Syntheses and Central Nervous System Activities of Some 6-(Methoxy-, dimethoxy-, methylenedioxy-, chloro- and fluoro-)-3-alkoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 46, no. 3 (1993): 353. http://dx.doi.org/10.1071/ch9930353.

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Syntheses are reported for 28 new 3-alkoxy-6-(3′-methoxy-,3′,4′-dimethoxy, 3′,4′-methylene-dioxy-, 2′- and 4′-chloro- and 4′-fluoro-benzylamino)-2-phenyl(and substituted phenyl) imidazo -[1,2-b] pyridazines from the corresponding 6-substituted pyridazin-3-amine 2-oxides with α- bromoacetophenones, followed by alkylation of the intermediate 3-hydroxyimidazo[1,2-b] pyridazines. In tests of the ability of these compounds to displace [3H]diazepam from rat brain membrane, 3-(2′-ethoxyethoxy)-6(3′-methoxybenzylamino)-2-phenyl- and 6(3′,4′-methylenedioxybenzylamino )-2-(3″,4″-methylenedioxyphenyl)-3-methoxy-imidazo[1,2-b] pyridazine bound most strongly, with IC50 values of 1nM.
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Sepsey Für, Csilla Sepsey, Gergő Riszter, Áron SzigetvárI, Miklós Dékány, György Keglevich, László HazaI, and Hedvig BölcskeI. "Novel Ring Systems: Spiro[Cycloalkane] Derivatives of Triazolo- and Tetrazolo-Pyridazines." Molecules 26, no. 8 (April 8, 2021): 2140. http://dx.doi.org/10.3390/molecules26082140.

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In orderto synthesize new pyridazine derivatives anellated with different nitrogen heterocyclic moieties, spiro[cycloalkane]pyridazinones were transformed into the corresponding thioxo derivatives via a reaction with phosphorus pentasulfide. The reaction of the formed 2,3-diazaspiro[5.5] undec-3-ene-1-thiones with hydrazine provided the corresponding 1-hydrazono-2,3-diazaspiro[5.5] undec-3-ene, whose diazotization led to the desired spiro[cyclohexane-1,8′-tetrazolo[1,5-b]pyridazines. The reaction of dihydropyridazinethiones with benzhydrazide afforded the corresponding 7H-spiro[[1,2,4]triazolo[4,3-b]pyridazin-8,1′-cyclohexanes]. As a result of our work, seven new pyridazinethione intermediates were prepared, which served as starting materials for the synthesis of two kinds of new ring systems: tetrazolo-pyridazines and triazolo-pyridazines. The six new annulated derivatives were characterized by physicochemical parameters. The new N-heterocycles are valuable members of the large family of pyridazines.
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Asif, Mohammad. "The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2Synthase." Journal of Chemistry 2014 (2014): 1–16. http://dx.doi.org/10.1155/2014/703238.

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The pyridazine moiety is an important structural feature of various pharmacological active compounds. Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is, inhibitors of prostaglandin or cyclooxygenase (COX-I & COX-II) enzyme, platelet cAMP phosphodiesterase, and thromboxane A2 (TXA2) synthase. These compounds are selective and nonselective COX inhibitors and showed analgesic, anti-inflammatory, and antipyretic activity. Pyridazine compounds with antiplatelet agents inhibited TXA2enzyme. Pyridazines also exhibited antirheumatoid activity. These pyridazine compounds hold considerable interest relative to the preparation of organic intermediates and other anticipated biologically active compounds.
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Barlin, GB, LP Davies, SJ Ireland, and JK Zhang. "Imidazo[1,2-b]pyridazines. XI. Syntheses and Central Nervous System Activities of Some 6-(N-Benzyl-N-methylamino)-3-methoxy-2-phenyl(and substituted phenyl)imidazo[1,2-b]pyridazines." Australian Journal of Chemistry 45, no. 4 (1992): 751. http://dx.doi.org/10.1071/ch9920751.

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Syntheses are reported for 196-(N-benzyl-N-methylamino )-3-methoxy-2-phenyl(and substituted phenyl or pyridinyl ) imidazo [1,2-b] pyridazines from 6-(N-benzyl-N-methylamino)pyridazin-3- amine 2-oxide. The ability of each of these compounds to displace [3H]diazepam from rat brain membrane preparations was measured and the IC50 values (or percentage displacements) are reported and discussed. 6-(N-Benzyl-N-methylamino )-3-methoxy-2-phenylimido[1,2-b]pyridine was about half as active as its 6-bemylamino analogue, and the most active compound was 6-(N-benzyl-N-methylamino )-2-(2'-fluorophenyl)-3-methoxyimido[1,2-b] pyridazine with IC50 9.8 nM.
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Dissertations / Theses on the topic "Pyridazine"

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Byrichetti, Kiranmai. "Synthesis and Structure of a Substituted Pyridazine." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1080.

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Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that utilize organics as the semiconducting material. The synthesis of 5, 6-fused ring pyridazines beginning from fulvenes (Scheme 1) is described herein. These fused heterocycles will serve as synthetic models and building blocks for potential organic or organometallic conducting polymers. Our goal was to modify the route of Snyder et al. previously reported for the direct synthesis of pyridazine 2. This required improved synthesis of fulvene 1 and higher yields of 5. Additionally, a thorough analysis of the x-ray data was obtained to better understand the 3D aspects of this compound (pyridazine 2).This route was quite general and features an efficient and convenient synthesis. Single crystal X-ray analysis confirms the molecular structure of pyridazine 2. Full synthesis and characterization of newly formed pyridazine 2 and Fulvene 1 are reported.
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Mernari, Bouchaïb. "Complexes binucléaires de dérivés de la pyridazyne ou du pyrazole : synthèses, structures cristallines et interactions magnétiques." Lille 1, 1987. http://www.theses.fr/1987LIL10015.

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Tran, Gaël. "Synthèse de phosphonylpyrazoles et de fluoropyridazines." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066414/document.

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Dans le cadre de nos travaux, nous avons développés des voies de synthèses permettant d'accéder à deux familles d'hétérocycles aromatiques: les phosphonylpyrazoles, et les fluoropyridazines. La synthèse des pyrazoles phosphonylés a été réalisée en utilisant un couplage croisé pallado-catalysé de type Hirao, et nous avons démontré qu'un système catalytique unique à base de Pd(OAc)2/XantPhos pouvait catalyser le couplage entre une large gamme d'halogénopyrazoles et de H-phosphonyles. Bien que souffrant de certaines limites dans son champ d'application, notamment au niveau du motif de substitution de l'halogénopyrazole, cette méthode consiste probablement à l'heure actuelle la voie d'accès la plus modulable pour accéder aux pyrazoles phosphonylés.Les 5-fluoropyridazines ont été synthétisées par réactions de cycloadditions séquentielles [2+1]/[3+2] entres des alcynes, le difluorocarbène :CF2, et des diazoacétates d'alkyles. Nous avons démontré que cette séquence réactionnelle était compatible avec un grand nombre d'alcynes diversement substitués, et que les 5-fluoropyridazines ainsi obtenues pouvaient être aisément fonctionnalisées
The work presented in this manuscript concerns the development of synthetic routes to two families of heterocycles, namely phosphonylpyrazoles and fluoropyridazines. Phosphonylpyrazoles were synthesized using a Hirao-type cross-coupling, and it was demonstrated during this study that a single catalytic system based on Pd(OAc)2/XantPhos could perform the cross-coupling between a wide range of halopyrazoles and H-phosphonyls. Significant limits have been met in the scope of this method, especially regarding the substitution pattern of the halopyrazole. Nevertheless, at this time, this method is arguably one of the most flexible ways to synthesize phosphonylpyrazoles. Fluoropyridazines were synthesized using a [2+1]/[3+2] cycloaddition sequence between alkynes, the difluorocarbene :CF2, and alkyl diazoacetates. It was demonstrated during this study that a wide range of alkynes could be involved in this sequence, and that the corresponding 5-fluoropyridazines could be easily diversified
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Foster, Joshua B. "Development of Pyridazine-Derivatives for the Treatment of Neurological Disorders." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1545904228813231.

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Bakkali, Hicham. "Synthèse d'analogues pyrroliques par régression de cycle thiaziniques et pyridaziniques : application pour l'élaboration de nouveaux ligands pyridaziniques et pyrroliques." Nantes, 2005. http://www.theses.fr/2005NANT2132.

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La première partie de la thèse, représente une application directe de la méthodologie de synthèse de pyrroles par régression de cycles thiaziniques. Nous décrivons l'accès à une nouvelle famille d'analogues dihydroquinoléiniques présentant un potentiel biologique à partir de précurseurs aminoaryl-thiaziniques. Dans la seconde partie du document, une nouvelle méthodologie de régression de cycle par voie électrochimique est présentée. Cette méthode permet de contrôler l'extrusion d'atome d'azote à partir de précurseurs pyridinyl-pyridaziniques pour former les analogues pyrroliques avec de meilleurs rendements que par voie chimique. Des petites molécules bis-pyridinyl-pyrroliques ont été évaluées en tant qu'antiviraux potentiels. Dans une troisième partie, la préparation de ligands pyridaziniques complexes est décrite. L'étude de la régression de cycle de précurseurs bipyridaziniques en analogue bipyrroliques est discutée. Une partie de ces composés pyridaziniques et pyrroliques a été utilisée pour la complexation sélective de métaux Actinides dans mélanges radioactifs An(III)/Ln(III) par extraction liquide-liquide au CEA de Marcoule.
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林浩強 and Ho-keung Lam. "Inhibitory effect of tetramethylpyrazine (TMP) on nitric oxide production in macrophages." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970163.

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Vaccarella, Graziano. "Synthesis and activity of pyridazine analogues of the excitatory neurotransmitter, glutamic acid." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27573.

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The synthesis and pharmacological assessment of novel pyridazine analogues of the neurotransmitter glutamic acid was the focus of this investigation. The project aimed to prepare agents for selective activation of the AMPA receptor subtype. The proposition investigated was that the six-membered pyridazine ring with an acidic hydroxyl group would provide a versatile carboxylic acid bioisostere and these compounds would be amenable to further derivatisation.
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Mojovic, Ljubica. "Métallations et synthèses en série pyrazinique et pyridazinique." Rouen, 1990. http://www.theses.fr/1990ROUES033.

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Nous avons appliqué pour la première fois, la réaction de métallation à la synthèse de dérivés de la pyrazine et de la pyridazine. Ces composés nous ont permis d'effectuer des réactions de couplage catalysées par le palladium et de préparer des analogues en série diaziniques de composés biologiquement actifs: diazépines, xanthones. Nous avons proposé une nouvelle voie d'accès a un produit pharmaceutique connu
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Mackrell, Alexander David. "Towards the structural modelling of the active site of ascorbate oxidase." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368242.

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Schmitt, Benoît. "5,6,7,8-tétrahydro-1,6-naphtyridines : dérivés et analogues structuraux." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13210.

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Books on the topic "Pyridazine"

1

The pyridazines. New York: Wiley, 2000.

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Cinnolines and phthalazines: Supplement 2. Hoboken, N.J: Wiley, 2005.

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Mayer, Michael. Farbe und Konstitution bei H-Chelaten der Pyrazinreihe: Präparative und spektroskopische Untersuchungen. Konstanz: Hartung-Gorre, 1985.

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The pyrazines. New York: John Wiley & Sons, 2002.

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Güven, Alâettin. Potentially tautomeric pyridazino (4,5-b) indolones. Norwich: University of East Anglia, 1992.

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A, Graf Josef. Struktur-Funktionsbeziehungen zwischen Lipidmatrix und Pigment-Protein-Komplexen in Thylakoidmembranen: Physiologische und fluoreszenzspektroskopische Untersuchungen zur Wirkung von Pyridazinonen, Cytokininen und Cerulenin bei Petunia hybrida. Stuttgart: [Biologisches Institut der Universität Stuttgart], 1987.

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Taylor, Edward C., Peter Wipf, and Desmond J. Brown. Supplement 1, Pyridazines. Wiley-Interscience, 1999.

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Simpson, J. C. Pyridazine and Pyrazine Rings : (Cinnolines, Phthalazines, and Quinoxalines). Wiley & Sons, Incorporated, John, 2009.

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Simpson, J. C. Chemistry of Heterocyclic Compounds, Pyridazine and Pyrazine Rings. Wiley & Sons, Incorporated, John, 2008.

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Brown, D. J. Pyrazines, Volume 58, Supplement 1. Wiley & Sons, Incorporated, John, 2003.

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Book chapters on the topic "Pyridazine"

1

Demaison, J. "410 C4H4N2 Pyridazine." In Asymmetric Top Molecules. Part 2, 289. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_158.

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Winkelmann, Jochen. "Self-diffusion coefficient of pyridazine." In Diffusion in Gases, Liquids and Electrolytes, 193. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-540-73735-3_102.

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Lenhert, Anne G., and Raymond N. Castle. "Pyridazine Aldehydes, Ketones, and Alcohols." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 353–406. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186985.ch4.

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Horkel, Ernst. "Metalation of Pyridazine, Cinnoline, and Phthalazine." In Topics in Heterocyclic Chemistry, 223–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/7081_2012_97.

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Amoo, Victor E., Charles R. Harrison, George P. Lahm, Patrick D. Lowder, Thomas M. Stevenson, Jeffrey K. Long, Rafael Shapiro, et al. "Pyridazine Insecticides: Synthesis and Biological Activity." In ACS Symposium Series, 156–65. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2002-0800.ch015.

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Demaison, J. "401 C4H4ArN2 Pyridazine - argon (1/1)." In Asymmetric Top Molecules. Part 2, 274. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_149.

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Demaison, J. "442 C4H6N2O Pyridazine - water (1/1)." In Asymmetric Top Molecules. Part 2, 337. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_190.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of Bis[(μ-nitrato-O)bis(nitrato)bis(μ-pyridazine)(pyridazine) copper(II)]copper(II)." In Magnetic Properties of Paramagnetic Compounds, 55–56. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_23.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of trinuclear pyridazine-bridged Cu2Ni complex." In Magnetic Properties of Paramagnetic Compounds, 137–38. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_60.

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Shaner, Dale L., Laurine M. Speltz, and Stephen S. Szucs. "Synthesis and Herbicidal Activity of Pyridazines Based on 3-Chloro-4-methyl-6-[m-(trifluoromethyl)phenyl]pyridazine." In ACS Symposium Series, 24–35. Washington, DC: American Chemical Society, 1987. http://dx.doi.org/10.1021/bk-1987-0355.ch003.

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Conference papers on the topic "Pyridazine"

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Salaheldin, Abdellatif, Lígia Rodrigues, and Ana Oliveira-Campos. "Heterocyclic Synthesis with Nitriles: Synthesis of Pyridazine and Pyridopyridazine Derivatives." In The 11th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01319.

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Salim, Muath Bani, and Reza Nekovei. "Designing of PCBM Derivative using Pyridazine Compound for More Efficient Bulk Heterojunction Organic Solar Cell." In 2021 IEEE 48th Photovoltaic Specialists Conference (PVSC). IEEE, 2021. http://dx.doi.org/10.1109/pvsc43889.2021.9519059.

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Franich, Andjela, Ivana Vasić, Snežana Rajković, Aleksandar Arsenijević, Marija Milovanović, Nebojša Arsenijević, Jelena Milovanović, and Marija Živković. "CYTOTOXICITY OF CATIONIC DINUCLEAR PLATINUM(II) COMPLEXES IN AN EXPERIMENTAL MODEL OF MOUSE COLON CANCER." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.293f.

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Abstract:
The series of nine dinuclear platinum(II) complexes, [{Pt(L)Cl}2(μ-X)]2+ (where L is two NH3 or bidentantly coordinated diamine ligand – ethylenediamine, en; (±)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(±)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2- dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd; (±)-1,3-pentanediamine,1,3-pnd, and X is a bridging pyrazine (pz) or pyridazine (pydz) ligand) have been synthesized and characterized. The antitumor potential of these complexes against CT26 cells were determined by in vitro and in vivo assays. A murine model of heterotopic colon cancer tumor was induced in immunocompetent BALB/c mice for investigating antitumor potential of the Pt(II) complexes in vivo. It was found that complexes Pt1, Pt2 and Pt7 shows significant in vitro cytotoxic activity against mouse colon carcinoma CT26 cells, while all these complexes show moderate apoptotic effect. Complexes Pt1 and Pt7 arrested CT26 cells in G2/M phase of cell cycle, while complexes Pt5 and Pt6 exerted the highest antiproliferative effect which was evaluated by detection of Ki67 expressing cells. Complexes Pt1 and Pt2 performed significant in vivo antitumor effects reducing the growth of primary tumor and the incidence of lung and liver metastases without causing the significant hepato- and nephro- toxicity.
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Tarby, Christine M., Liqi He, Brian E. Fink, Andrew Nation, Yufen Zhao, Soong-Hoon Kim, Libing Chen, et al. "Abstract 5417: The identification of BMS-595, an orally active imidazo[1,2-b]pyridazine CK2 inhibitor with in vivo anti-tumor activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5417.

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Spearman, P., S. Tavazzi, L. Silvestri, A. Burini, A. Borghesi, P. Mercandelli, M. Panigati, G. D'Alfonso, A. Sironi, and L. De Cola. "The role of molecular packing on the UV-visible optical properties of [Re 2 Cl 2 (CO) 6 4,5-(Me 3 Si) 2 pyridazine]." In SPIE Photonics Europe, edited by Barry P. Rand, Chihaya Adachi, and Volker van Elsbergen. SPIE, 2012. http://dx.doi.org/10.1117/12.922988.

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Troitskaya-Markova, Nadezhda, Olga Vlasova, and Oleg Rakitin. "4,5-DIOXO-4,5-DIHYDRO-4Λ4,5Λ4-BIS([1,2,5]OXADIAZOLO)[3,4-с:3',4'-e]PYRIDAZINE AS A SYNTHETIC EQUIVALENT OF 4,4'-DINITROSO-3,3'-BI(1,2,5-OXADIAZOLE)." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m779.aks-2019/305-307.

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Hosmane, Ramachandra, and Huan-Ming Chen. "Synthesis of 1-(2'-Deoxy-γ-D-ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5 H,6H)-dion: a Potentially Beneficial Building Block for Antisense Applications." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01926.

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Hosmane, Ramachandra, and Huan-Ming Chen. "Synthesis of 1-(2'-O-Methyl-γ -D-Ribofuranosyl)-1H-imidazo[4,5-d]pyridazine-4,7(5H,6H)-dion: an Attractive Building Block for Antisense and Triple-helical Applications." In The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01925.

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Titov, I. Yu, V. S. Stroylov, O. V. Stroganov, F. N. Novikov, I. V. Svitanko, and G. G. Chilov. "NOVEL 5,6,7,8-TETRAHYDROPYRAZINO[2,3-c]PYRIDAZINE3-CARBOXAMIDE DERIVATIVES AS DUAL ALK/NUAK1 INHIBITORS." In MedChem-Russia 2021. Издательство Волгоградского государственного медицинского университета, 2022. http://dx.doi.org/10.19163/medchemrussia2021-2022-25.

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Floresta, Giuseppe, Letizia Crocetti, Chiara Zagni, and Agostino Cilibrizzi. "Pyridazin-3(2H)-one as New FABP4 Inhibitors Suggested by Molecular Growing Experiments." In ECMC 2022. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13445.

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