Relevant bibliographies by topics / Pyrazoles

Academic literature on the topic 'Pyrazoles'

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Published: 4 June 2021
Last updated: 22 June 2024

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Journal articles on the topic "Pyrazoles"

1

Alsayari, Abdulrhman, Abdullatif Bin Muhsinah, Yahya I. Asiri, Jaber Abdullah Alshehri, Yahia N. Mabkhot, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Mater H. Mahnashi, and Mohd Zaheen Hassan. "Arylhydrazono/Aryldiazenyl Pyrazoles: Green One-Pot Solvent-Free Synthesis and Anticancer Evaluation." Letters in Organic Chemistry 17, no. 10 (November 17, 2020): 772–78. http://dx.doi.org/10.2174/1570178617666200320104923.

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The aim of this study was to synthesize and evaluate the biological activity of pyrazole derivatives, in particular, to perform a “greener” one-pot synthesis using a solvent-free method as an alternative strategy for synthesizing hydrazono/diazenyl-pyridine-pyrazole hybrid molecules with potential anticancer activity. Effective treatment for all types of cancers is still a long way in the future due to the severe adverse drug reactions and drug resistance associated with current drugs. Therefore, there is a pressing need to develop safer and more effective anticancer agents. In this context, some hybrid analogues containing the bioactive pharmacophores viz. pyrazole, pyridine, and diazo scaffolds were synthesized by one-pot method. Herein, we describe the expedient synthesis of pyrazoles by a onepot three-component condensation of ethyl acetoacetate/acetylacetone, isoniazid, and arenediazonium salts under solvent-free conditions, and the evaluation of their cytotoxicity using a sulforhodamine B assay on three cancer cell lines. Molecular docking studies employing tyrosine kinase were also carried out to evaluate the binding mode of the pyrazole derivatives under study. 1-(4-Pyridinylcarbonyl)-3- methyl-4-(2-arylhydrazono)-2-pyrazolin-5-ones and [4-(2-aryldiazenyl)-3,5-dimethyl-1H-pyrazol-1- yl]-4-pyridinylmethanones, previously described, were prepared using an improved procedure. Among these ten products, 1-isonicotinoyl-3-methyl-4-[2-(4-nitrophenyl)hydrazono]-2-pyrazolin-5-one (1f) displayed promising anticancer activity against the MCF-7, HepG2 and HCT-116 cell lines, with an IC50 value in the range of 0.2-3.4 μM. In summary, our findings suggest that pyrazoles containing hydrazono/ diazenyl and pyridine pharmacophores constitute promising scaffolds for the development of new anticancer agents.
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Elnagdi, Mohamed Hilmy, Ahmed Hafez Hussien Elghandour, Kamal Usef Sadek, and Mahmoud Mohamed Mahfouz Ramiz. "Studies on Condensed Pyrazoles. A New Route for Synthesis of Pyrazolo[4,3-c]pyrazoles." Zeitschrift für Naturforschung B 44, no. 8 (August 1, 1989): 951–54. http://dx.doi.org/10.1515/znb-1989-0816.

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A novel synthesis of pyrazolo[4,3-c]pyrazoles via 1,5-dipolar cyclization of products of coupling of 2,3-dimethyl-1-phenyl-5-oxo-3-pyrazolin-4-diazonium chloride with active methylene reagents is reported.
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Chauhan, Pankaj, Suruchi Mahajan, and Dieter Enders. "Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives." Chemical Communications 51, no. 65 (2015): 12890–907. http://dx.doi.org/10.1039/c5cc04930j.

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The various catalytic asymmetric strategies employing organo- and metal-catalysts utilized pyrazolin-5-one derivatives for the synthesis of potentially bioactive enantiopure pyrazoles and pyrazolones are presented.
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4

Lin, Wei-Syuan, and Shigeki Kuwata. "Recent Developments in Reactions and Catalysis of Protic Pyrazole Complexes." Molecules 28, no. 8 (April 17, 2023): 3529. http://dx.doi.org/10.3390/molecules28083529.

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Protic pyrazoles (N-unsubstituted pyrazoles) have been versatile ligands in various fields, such as materials chemistry and homogeneous catalysis, owing to their proton-responsive nature. This review provides an overview of the reactivities of protic pyrazole complexes. The coordination chemistry of pincer-type 2,6-bis(1H-pyrazol-3-yl)pyridines is first surveyed as a class of compounds for which significant advances have made in the last decade. The stoichiometric reactivities of protic pyrazole complexes with inorganic nitrogenous compounds are then described, which possibly relates to the inorganic nitrogen cycle in nature. The last part of this article is devoted to outlining the catalytic application of protic pyrazole complexes, emphasizing the mechanistic aspect. The role of the NH group in the protic pyrazole ligand and resulting metal–ligand cooperation in these transformations are discussed.
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Queiroz, Jaqueline E., Lucas D. Dias, Giuliana M. Vila Verde, Gilberto L. B. Aquino, and Ademir J. Camargo. "An Update on the Synthesis and Pharmacological Properties of Pyrazoles Obtained from Chalcone." Current Organic Chemistry 26, no. 2 (January 2022): 81–90. http://dx.doi.org/10.2174/1385272826666220119110347.

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Abstract: A review concerning the synthesis and pharmacological properties of pyrazoles obtained from Chalcone described in the literature over the last 5 years (2016-2020) was presented and discussed. Among the synthetic approaches for pyrazoles described so far, the cyclization and acetylation method of α,β-unsaturated chalcones, and substituted hydrazine were selected and analyzed. 105 pyrazole derivatives (3-107) were evaluated as well as their pharmacological activities, namely, antineoplastic, anti-inflammatory, antioxidant, antibacterial, antifungal, antimycobacterial, antiplasmodial, Alzheimer's disease, enzymes inhibition (like acetylcholinesterase, carbonic anhydrase, and malonyl CoA decarboxylase), anticonvulsant, among others. Pyrazolic compounds are widely used in the design of the new drug with a wide spectrum of pharmacological approaches. Therefore, it is relevant to research the synthetic methods and therapeutic properties of different pyrazole derivatives.
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Milišiūnaitė, Vaida, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, Wolfgang Holzer, and Algirdas Šačkus. "Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction." Beilstein Journal of Organic Chemistry 15 (March 14, 2019): 679–84. http://dx.doi.org/10.3762/bjoc.15.62.

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Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and functional properties remain largely underexplored. The current study investigates routes to construct this system from easily accessible starting materials using metal-catalyzed reactions. A simple and efficient procedure to access the 2H-furo[2,3-c]pyrazole ring system was developed by employing the silver(I) ion-mediated ring-closure reaction of 4-alkynyl-3-hydroxy-1-phenyl-1H-pyrazoles as a key step. The required intermediate hydroxyalkynyl substrates for this reaction were prepared by a Pd-catalyzed coupling of 4-iodo-1-phenyl-1H-pyrazol-3-ol with ethyne derivatives. The structures of the obtained target compounds were unequivocally confirmed by detailed 1H, 13C and 15N NMR spectroscopic experiments, HRMS and a single-crystal X-ray diffraction analyses. This silver(I)-mediated 5-endo-dig cyclization of readily available 4-alkynyl-3-hydroxy-1H-pyrazoles can be used as an efficient method to access many novel 2,5-disubstituted 2H-furo[2,3-c]pyrazoles.
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Lam, Linh, Sang H. Park, and Joseph Sloop. "Synthesis and Characterization of 3-Methyl-1-(4-(trifluoromethyl)phenyl)indeno [1,2-c]pyrazol-4(1H)-one." Molbank 2022, no. 4 (November 7, 2022): M1483. http://dx.doi.org/10.3390/m1483.

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Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, and antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties. Herein, we report the acid-catalyzed synthesis of a new tricyclic, trifluoromethylated indenopyrazole, 3-methyl-1-(4-(trifluoromethyl)phenyl)indeno[1,2-c]pyrazol-4(1H)-one, from 2-acetyl-1,3-indanedione and 4-trifluoromethylphenylhydrazine. This isomeric pyrazole was obtained in yields ranging from 4–24%. NMR spectroscopic characterization and elemental analysis support the structural assignment, identity, and purity of the product.
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Lindsay-Scott, Peter J., and Eloise Rivlin-Derrick. "Regiocontrolled Synthesis of 6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]oxazines." Synthesis 52, no. 01 (October 8, 2019): 105–18. http://dx.doi.org/10.1055/s-0037-1610734.

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Synthetic access to 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazines has been achieved in 3–4 steps from commercially available pyrazoles. Optimization of a protected hydroxyethyl group on N1 enabled the regiocontrolled construction of pyrazole-5-aldehydes in high yields; subsequent deprotection and reduction generated fused heterocyclic scaffolds bearing multiple substitution patterns. Moreover, the intermediate pyrazole lactols were shown to be versatile synthetic building blocks.
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Mantzanidou, Martha, Eleni Pontiki, and Dimitra Hadjipavlou-Litina. "Pyrazoles and Pyrazolines as Anti-Inflammatory Agents." Molecules 26, no. 11 (June 5, 2021): 3439. http://dx.doi.org/10.3390/molecules26113439.

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The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The synthesis of the pyrazolines and pyrazole derivatives was accomplished via the condensation of the appropriate substituted aldehydes and acetophenones, suitable chalcones and hydrazine hydrate in absolute ethanol in the presence of drops of glacial acetic acid. The compounds are obtained in good yields 68–99% and their structure was confirmed using IR, 1H-NMR, 13C-NMR and elemental analysis. The novel derivatives were studied in vitro for their antioxidant, anti-lipid peroxidation (AAPH) activities and inhibitory activity of lipoxygenase. Both classes strongly inhibit lipid peroxidation. Compound 2g was the most potent lipoxygenase inhibitor (IC50 = 80 µM). The inhibition of the carrageenin-induced paw edema (CPE) and nociception was also determined, with compounds 2d and 2e being the most potent. Compound 2e inhibited nociception higher than 2d. Pyrazoline 2d was found to be active in a preliminary test, for the investigation of anti-adjuvant-induced disease (AID) activity. Pyrazoline derivatives were found to be more potent than pyrazoles. Docking studies of the most potent LOX inhibitor 2g highlight hydrophobic interactions with VAL126, PHE143, VAL520 and LYS526 and a halogen bond between the chlorine atom and ARG182.
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Warkentin, John, and John Mck R. Woollard. "Photolysis of 5,5-dibenzyl-Δ3-1,3,4-oxadiazolines." Canadian Journal of Chemistry 75, no. 3 (March 1, 1997): 289–307. http://dx.doi.org/10.1139/v97-033.

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Photolysis of dibenzyl-Δ3-1,3,4-oxadiazolines (3) in the presence of dimethyl acetylenedicarboxylate (DMAD) gives only modest yields of the expected symmetrical 3,3-dibenzylcyclopropenes (4), but these are accompanied by more than six by-products, including unsymmetrical cyclopropenes, methylenecyclopropanes, and various pyrazoles. The origin of this array of products can be explained by a series of steps starting with photolysis of 3 to form a diazoalkane that undergoes 1,3-dipolar cycloaddition to DMAD, generating a 3H-pyrazole as initial product. The latter is further photolyzed to a symmetrical cyclopropene in competition with benzyl group migration by thermal 1,5-sigmatropic or ion-pair rearrangement to afford a 4H-pyrazole. The 4H-pyrazole in turn undergoes photolysis to an unsymmetrical cyclopropene, which rearranges to a methylenecyclopropane. The 4H-pyrazole also undergoes autoxidation, in the presence of air, to afford a benzoyl-4H-pyrazole. Additionally, in competition with rearrangement, the various pyrazoles lose a benzyl group or a methoxycarbonyl group to afford pyrazoles with one less substituent. Keywords: 5,5-dibenzyl-Δ3-1,3,4-oxadiazolines, photolysis of; 3,3-dibenzyl-3H-pyrazoles, rearrangement of; 3,4-dibenzyl-4H-pyrazoles, autoxidation of; 3,4-dibenzyl-4H-pyrazoles, photolysis of; cyclopropenes, rearrangement to methylenecyclopropanes.
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Dissertations / Theses on the topic "Pyrazoles"

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Ostache, Nicu-Carmin. "Synthèse et fonctionnalisation de bicycles 5-5 polyazotés : pyrazolo[3,4-d]thiazoles et pyrazolo[3,4-c]pyrazoles." Thesis, Orléans, 2019. http://intranet.univ-orleans.fr/bibliotheques/theses/nicu-cosmin-ostache_3378_vm.pdf/.

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Les structures bicycliques azotées sont parmi les entités les plus utilisées dans le domaine thérapeutique.Les bicycles 5:5 polyazotés sont des structures moins décrites que leurs analogues 6:6 ou6:5. Malgré le potentiel pharmacologique des pyrazolo [3,4-d] thiazoles et des pyrazolo [3,4-c] pyrazoles,deux exemples de ces familles rares, seuls quelques procédés de préparation et de fonctionnalisationdirecte de ces charpentes hétérocycliques sont décrits.De ce fait, l’objectif principal de nos recherches vise à développer de nouvelles voies de synthèse vers cesdeux charpentes bicycliques et ce, à partir de substrats facilement accessibles. Des stratégies efficaces ontété mises au point et s’appuient sur réactions de condensations avec des hydrazines, des N-cyclisationsintramoléculaires, des halogénations chimiosélectives et diverses réactions de couplage-croisé. De surcroît,le motif pyrazolo[3,4-d]thiazole a été fusionné à une structure triazapentalène, afin d’évaluer les propriétésspectroscopiques
Nitrogen-rich fused bicyclic structures are undisputedly one of the most used scaffolds for therapeutic use.The 5:5 polynitrogenated bicycles are moieties considerably less documented then their 6:6 or 6:5analogues. Despite the pharmacological potential of the pyrazolo[3,4-d]thiazoles and of thepyrazolo[3,4-c]pyrazoles, two examples of such rare families, only few methods of preparation and directfunctionalization of these heterocyclic moieties have been described.In this context, the main goal of our research aims at exploring new routes towards these bicyclic systemsfrom readily available and affordable starting materials. Efficient strategies were developed relying onhydrazine condensations, on intramolecular N-cyclizations, on chemo-selective halogenation and variouscross-coupling reactions. Moreover, the pyrazolo[3,4-d]thiazole entity was fused to a triazapentalenestructure in order to assess the spectroscopic properties
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Gormen, Meral. "Synthesis Of Ferrocenyl Substituted Pyrazoles." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12606358/index.pdf.

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Pyrazoles have been studied for over a century as an important class of heterocyclic compounds and continue to attract considerable interest due to the broad range of biological activities they possess. The incorporation of the essential structural features of pyrazoles with a ferrocene moiety could provide new derivatives with unexpected and/or enhanced biological activities since several ferrocene derivatives have already been shown to be active against a number of tumors. For this reason, we investigated the synthesis of ferrocenyl-substituted pyrazoles, such as 1-alkyl/aryl-5-ferrocenylpyrazoles, by employing the reaction between (2-formyl-1-chlorovinyl)ferrocene and hydrazine derivatives. Although this reaction is known, it was not studied in much detail and the low yields of ferrocenyl pyrazoles were obtained. Thus, we have reinvestigated this reaction and improved the yields of pyrazoles by optimizing the reaction conditions. (2-Formyl-1-chloro vinyl)ferrocene was first reacted with the excess amount (3 equivalents) of hydrazine derivative at 25 0C in dioxane under argon for 2 hours, and the resulting mixture was then heated at 100 0C for 6 hours in the same solvent. Under our optimized conditions, these reactions afforded 1-alkyl/aryl-5-ferrocenylpyrazole derivatives in moderate to good yields as a single or major product of the reaction. In some cases, 1-alkyl/aryl-3-ferrocenylpyrazole derivatives resulted from these reactions as very minor products.
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El, Youssoufi Jawad. "Synthèses de pyrazoles benzocyclohepténiques glycosylés." Limoges, 1997. http://www.theses.fr/1997LIMO0027.

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La synthese des pyrazoles constitue un developpement important dans le domaine de la chimie fine en raison de leur impact en pharmacochimie ou lors de l'elaboration de produits phytosanitaires et insecticides. Dans le present travail nous presentons pour la premiere fois la synthese de dipyrazoles benzocyclohepteniques substitues. Cette synthese passe par deux synthons cles, le 1,5-dioxo-1,2,4,5-tetrahydro-3h-benzocycloheptene-2,4-diaminomethylene et le 1,5-dihydroxy-3h-benzocycloheptene-2,4-dicarbonitrile. Ces deux composes permettent une synthese regioselective de deux series de pyrazoles substitues sur les azotes n-1, n-7 ou sur les azotes n-2, n-6 par des groupements methyles, hydroxyethyles et glycosyles. L'equilibre conformationnel du cycloheptene, mis en evidence par differentes methodes de rmn, revele des structures tridimensionnelles differentes pour chacune des series. Le couplage de ces produits avec le ribose nous a permis d'obtenir des produits hydrosolubles mono et diglycosyles directement sur le pyrazole ou par l'intermediaire d'un bras espaceur. Les methodes presentees pour l'elaboration de ces composes sont suffisamment generales pour permettre des couplages regio et stereoselectifs avec un large eventail de glucides mono ou polysaccharidiques.
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Ervithayasuporn, Vuthichai. "Synthesis and photochemistry of pyrano[2,3-c]pyrazoles." Link to electronic thesis, 2006. http://www.wpi.edu/Pubs/ETD/Available/etd-042006-160619/.

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ERVITHAYASUPORN, VUTHICHAI. "Synthesis and Photochemistry of Pyrano[2,3-c]pyrazoles." Digital WPI, 2006. https://digitalcommons.wpi.edu/etd-theses/228.

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Two different synthetic approaches to the synthesis of pyrano[2,3-c]pyrazoles have been investigated. In one approach, dehydroacetic acid derivatives were treated with phenylhydrazine and methylhydrazine led to the formation of the phenylhydrazones and methylhydrazones, which undergo rearrangement in refluxing acetic acid to diketo-phenylpyrazoles and diketo-methylpyrazoles. Upon treatment with a mixture of acetic and sulfuric acid these compounds isomerize to the phenylpyrano[2,3-c]pyrazol-4-one and methylpyrano[2,3-c]pyrazol-4-one derivatives. In a second approach, phenylhydrazine and methylhydrazine reacted with dimethyl(methoxymethylene)malonate (34) to give phenylpyrazole and methylpyrazole ester derivatives which were converted to phenylpyrazolone and methylpyrazolone by hydrolysis and decarboxylation. C-acylation of these compounds with trans-cinnamoyl chloride gave á,â-unsaturated-4-acetyl-5-hydroxypyrazoles. Bromination of these á,â-unsaturated-4-acetyl-5-hydroxypyrazoles with spontaneous cyclization, followed by dehydrobromination led to pyrano[2,3-c]pyrazol-4-one derivatives, respectively. Phototochemical excitation of 1-phenyl and 1-methylpyrano[2,3-c]pyrazol-4-ones in acetonitrile led to the formation of cis-head-to-tail [2+2] cycloaddition products. Irradiation in ethanol solvent led to photodimerization and to photofragmentation to yield pyrazole ethylesters.
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Desalegn, Nebiyou. "Kinetic Studies Of The Thermolysis Of 3-Halogenated-4,5-Dihydro-3h-Pyrazoles." Digital Archive @ GSU, 2005. http://digitalarchive.gsu.edu/chemistry_theses/1.

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3-Chloro-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3b) and 3-bromo-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3c) were prepared for the thermolysis project. The thermal decompositions of 3b and 3c were monitored using 1H NMR spectroscopy. Plots of ln (% starting material) vs. time (sec) were linear for at least two half lives and the first order rate constants were determined over at least a 30o temperature range. The relative reactivity was found to be 3c > 3b. The activation parameters determined for the thermal decomposition of the pyrazoline at 150oC were found to be: for 3b &#;H‡ = 33 &#;1.0 kcal/mol, &#;S‡ = -2.4 &#; 0.07eu , k150 0 = 7.34 &#; 0.44 x 10 -5 s-1 ; for 3c &#;H‡ = 30&#;0.2 kcal/mol, &#;S‡ = -6.9 &#;0.03 eu, k150o = 42.3&#;0.7 x 10-5 s-1. Thermal decomposition of 3b both neat and in dibromobenzene (DBB) resulted in the formation of an intermediate 2,3-diphenyl-4-methyl-1,3-pentadiene (8) as a major product and minor isomers of 8. These intermediates then thermally decomposed to 1,1,3-trimethyl-2-phenyl-1H-indene (9) via an acid catalyzed process. In order to gain a mechanistic understanding (ionic vs. radical pathways) of the thermal decomposition of 3b, a product study was conducted in protic solvents. In methanol and ethanol, 3b underwent an ionic reaction (SN1-type) with the solvent to produce 3-methoxy/ethoxy-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (3/3d) in good yield. The reaction of 3b with refluxing protic solvents led to the development of new method for the synthesis of alkoxy-4,5-dihydro-3H-pyrazoles which is both safe and efficient.
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7

Cooper, David Arthur. "The synthesis and characterization of some molybdenum, rhenium and rhodium complexes incorporating pyrazolylgallate ligands." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24597.

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Several uninegative ligands based on a gallium core and incorporating pyrazolyl groups have been synthesized and their metathesis reactions with molybdenum, rhenium and rhodium halides have been studied. The bidentate pyrazolylgallate ligand [formula omitted] has been incorporated in the complexes [formula omitted]. The unsymmetric tridentate pyrazolylgallate ligands [formula omitted] display a variable reactivity towards molybdenum, rhenium and rhodium precursors. Although no complexes incorporating L⁴ were isolated, L₂ and L₃ were shown to co-ordinate facially in the octahedral complexes [formula omitted] and [formula omitted]. In addition, a meridional co-ordination geometry of L₂ has been structurally characterized in the square planar rhodium(I) complex, L₂Rh(CO). This co-ordinatively unsaturated rhodium(I) species was shown to undergo an interesting oxidative addition reaction with methyl iodide followed by a methyl migration reaction to give a rhodium(III) acetyl derivative. Less predictable products have also been obtained in this study; these include the dimeric species [formula omitted] formed from the reaction of NaL₃ with [formula omitted] and also an unexpected chlorine-containing complex, [formula omitted] from the reaction of [formula omitted]. [formula omitted] the product of the reaction between [formula omitted]. [Formula omitted] (the precursor of Ld) has been structurally shown to possess a novel eight-membered Ga-(N-C-S)₂-Ga ring.
Science, Faculty of
Chemistry, Department of
Graduate
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8

Nakhai, Azadeh. "Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives." Stockholm, 2009. http://diss.kib.ki.se/2009/978-91-7409-687-3/.

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9

Demirci, Deniz. "Synthesis Of 4-phenylselenyl-1h-pyrazoles By Electrophilic Cyclization." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613910/index.pdf.

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In this study, the synthesis of 5-ferrocenyl/aryl-4-(phenylselenyl)-1H-pyrazole derivatives was investigated since the integration of ferrocenyl and selenium moieties into pyrazole derivatives may increase their current biological activities. Initially, the starting propargyl aldehydes were synthesized from corresponding acetylenes. Subsequently, propargyl aldehydes were reacted with hydrazines to yield corresponding hydrazones. Then the in situ synthesized hydrazones were subjected to electrophilic cyclization with phenylselenyl chloride, which afforded 5-ferrocenyl/aryl-4-(phenylselenyl)-1H-pyrazoles in one-pot manner. Subsequently, reaction conditions were optimized in terms of electrophile, base, temperature and solvent. Best results were obtained with phenylselenyl chloride and NaHCO3 at room temperature in DCM for ferrocenyl substituted pyrazoles and DCE for aryl substituted pyrazoles. In summary, by employing the electrophilic cyclizations of in situ synthesized acetylenic hydrazones, a variety of 5-ferrocenyl/aryl-4-(phenylselenyl)-1H-pyrazole derivatives were synthesized in one-pot way in moderate to good yields.
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10

Truong, Phong Minh. "Hexa-aryl/alkylsubstituted Cyclopropanes." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/chemistry_theses/2.

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A series of penta-aryl/alkyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole 5a-c was synthesized by addition of methyllithium or phenylllithium followed by trapping the nitrogen anion intermediate with tosyl-fluoride to cyclic azines 2a,b. Addition of methyllithium or phenyllithium to 5a-c generated a series of hexa-aryl/alkylsubstituted-4,5-dihydro-3H-pyrazoles 6a-c. Neat thermolysis of hexa-aryl/alkylsubstituted-4,5-dihydro-3H-pyrazoles 6a-c at 200◦C produced hexa-aryl/alkylsubstituted cyclopropanes 7a-c in high yield.
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Books on the topic "Pyrazoles"

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Degtev, M. I. Fiziko-khimicheskie svoĭstva antipirina i ego proizvodnykh: Monografii︠a︡. Permʹ: Permskiĭ gos. universitet, 2010.

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Jacques, Teresa. I : Catalytic Direct C-H Arylation of Pyrazoles. II: Toward Modulation of Neuroplasticity with Small Molecules. [New York, N.Y.?]: [publisher not identified], 2013.

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Kresinski, Roman Alexander. Tris(pyrazolyl)borate complexes of Group IV metals. Birmingham: University of Birmingham, 1990.

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Karim, Mohammed. Composition de quelques pyrazolines: Etude de leur activité biologique. Saarbrücken: Noor Publishing, 2017.

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Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Incorporated, John, 2009.

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Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Limited, John, 2007.

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Wiley, Richard H. Pyrazoles and Reduced and Condensed Pyrazoles. Wiley & Sons, Incorporated, John, 2009.

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8

Wiley, Richard H. Chemistry of Heterocyclic Compounds, Pyrazoles and Reduced and Condensed Pyrazoles. Wiley & Sons, Incorporated, John, 2008.

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9

100 years of pyrazolone drugs: An update. Basel: Birkhäuser, 1986.

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Aktoudianakis, Evangelos. Synthesis of annulated pyrazoles via a tandem alkylation/direct arylation sequence. 2006.

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Book chapters on the topic "Pyrazoles"

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Rauf, Abdul, and Nida Nayyar Farshori. "Pyrazoles." In SpringerBriefs in Molecular Science, 39–46. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1485-4_6.

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Brown, E. G. "Pyrazoles." In Ring Nitrogen and Key Biomolecules, 60–67. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4906-8_3.

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Li, Jie Jack, and Minmin Yang. "Pyrazoles." In Drug Discovery with Privileged Building Blocks, 173–85. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003190806-21.

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Akhmetova, Vnira R., Nail S. Akhmadiev, and Askhat G. Ibragimov. "Sulfur-Containing Pyrazoles, Pyrazolines and Indazoles." In N-Heterocycles, 275–312. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-0832-3_7.

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Gandhi, Divyani, Ayushi Sethiya, Nusrat Sahiba, Dinesh Kumar Jangid, and Shikha Agarwal. "Nanocatalysed Synthesis of Pyrazoles, Indazoles, and Pyrazolines." In Nanocatalysis, 219–43. New York: CRC Press, 2022. http://dx.doi.org/10.1201/9781003141488-10.

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Fustero, Santos, Antonio Simón-Fuentes, Oscar Delgado, and Raquel Román. "Fluorinated Pyrazoles and Indazoles." In Fluorine in Heterocyclic Chemistry Volume 1, 279–321. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04346-3_7.

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Gupta, Shyam L., Surendra Saini, Pratibha Saini, Anshu Dandia, K. L. Ameta, and Vijay Parewa. "Pyrazoles, Indazoles and Pyrazolines: Recent Developments and Their Properties." In N-Heterocycles, 415–41. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-0832-3_12.

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Roy, Sudipta, Sujata Roy, and Gordon W. Gribble. "Metalation of Pyrazoles and Indazoles." In Topics in Heterocyclic Chemistry, 155–260. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/7081_2012_82.

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Elguero, José, Artur M. S. Silva, and Augusto C. Tomé. "Five-Membered Heterocycles: 1,2-Azoles. Part 1. Pyrazoles." In Modern Heterocyclic Chemistry, 635–725. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527637737.ch8.

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Hamper, Bruce C., Kindrick L. Leschinsky, Deborah A. Mischke, and S. Douglas Prosch. "Chiral 3-Aryl-4-halo-5-(trifluoromethyl)pyrazoles." In ACS Symposium Series, 272–81. Washington, DC: American Chemical Society, 1999. http://dx.doi.org/10.1021/bk-2000-0746.ch019.

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Conference papers on the topic "Pyrazoles"

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Zanatta, Nilo, Marcio M. Lobo, Bruna Canova, Helio G. Bonacorso, and Marcos A. P. Martins. "Regioselective synthesis of 1,3- and 1,5-substituted pyrazoles and pyrazolynes analogous of Celecoxib." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20138818469.

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Medjahed, Nassima, Zahira Kibou, Amina Berrichi, Redouane Bachir, and Noureddine Choukchou-Braham. "Nickel-Catalyzed, One-Pot Synthesis of Pyrazoles." In International Electronic Conference on Synthetic Organic Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecsoc-26-13687.

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Koos, M., B. Steiner, and J. Gajdos. "Synthesis of Some Sulfur Bridged Pyrimidines, Pyrazoles and Imidazoles." In The 1st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02002.

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Oumessaoud, Asmaa, Jamila Bouali, Salha Hamri, Hajiba Ouchetto, Abderrafia Hafid, Mostafa Khouili, and Maria Dolors Pujol. "Efficient Synthesis of New Pyrazoles Derivatives via Functionalized Aryl-Sydnones." In 1st International Electronic Conference on Catalysis Sciences. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/eccs2020-07565.

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Трофимов, Б., B. Trofimov, Н. Гусарова, and N. Gusarova. "The development of original methodologies of directed synthesis of le-Carbs their analogs and precursors base donacetylene and its derivatives." In Topical issues of translational medicine: a collection of articles dedicated to the 5th anniversary of the day The creation of a department for biomedical research and technology of the Irkutsk Scientific Center Siberian Branch of RAS. Москва: INFRA-M Academic Publishing LLC., 2017. http://dx.doi.org/10.12737/conferencearticle_58be81ec92d17.

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Abstract:
New reactions, which have been discovered and continue to be developed in A.E. Favorsky Irkutsk institute of chemistry SB RAS on the basis of acetylene, a product of oil, gas and coal processing and multi-faceted building block for organic synthesis, have been considered. These reactions provide for the shortest routes to construction of fundamental heterocyclic scaffolds (pyrroles, imidazoles, pyrazoles, indoles, pyridines, dihydropyridines, etc.) with desirable and optimum combination of functional pharmacophoric groups and fragments, which are responsible for antiviral (HIV, flu), antitumor, tuberculostatic and hypotensive activities.
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Yamini, G., M. Madhu Sekhar, G. Sravya, T. Sreenivasulu, A. Padmaja, and Grigory V. Zyryanov. "Green approach for the synthesis of some new diamidomethane linked pyridinyl pyrazoles." In PROCEEDINGS OF THE 3RD INTERNATIONAL CONFERENCE ON AUTOMOTIVE INNOVATION GREEN ENERGY VEHICLE: AIGEV 2018. Author(s), 2019. http://dx.doi.org/10.1063/1.5087400.

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Rocha, Sónia, Eduarda Fernandes, Marisa Freitas, Daniela Ribeiro, Vera Silva, Pedro Gomes, Artur Silva, Alberto Araújo, and M. Luísa Corvo. "Insight into the protein tyrosine phosphatase 1B (PTP1B) inhibitory activity of pyrazoles." In 6th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/ecmc2020-07490.

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Ramteke, Avinash A. "Study the adiabatic compressibility and acoustic impedance of chlorosubstituted pyrazoles in various solvent water mixtures." In ADVANCES IN BASIC SCIENCE (ICABS 2019). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5122382.

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Khatri, Taslimahemad Talab, Aadil Khursheed, and Pushpendra Kumar. "Water mediated synthesis of pyrano[2, 3-c]pyrazoles using L-histidine as an effective catalyst." In RECENT ADVANCES IN FUNDAMENTAL AND APPLIED SCIENCES: RAFAS2016. Author(s), 2017. http://dx.doi.org/10.1063/1.4990359.

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Galarraga, Elier, Neudo Urdaneta, and Julio Herrera. "In vitro Anti-leishmanial and Anti-trypanosomal Activity of Hydrazones, Pyrazoles, Pyrazolo[1,5-a]pyrimidines and Pyrazolo[3,4-b]pyridines Synthesized from 6-Substituted-3-formylchromones." In 2nd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecmc-2-a003.

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Reports on the topic "Pyrazoles"

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Habben, C., L. Komorowski, W. Maringgele, A. Meller, and K. Niedenzu. Reactions of Some Boron Heterocycles with Pyrazole. Fort Belvoir, VA: Defense Technical Information Center, March 1989. http://dx.doi.org/10.21236/ada205979.

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Theopold, K. H. [Oxidation catalysis with tris(pyrazolyl)borate metal complexes]. Office of Scientific and Technical Information (OSTI), January 1993. http://dx.doi.org/10.2172/6487292.

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Theopold, K. H. [Oxidation catalysis with tris(pyrazolyl)borate metal complexes]. Progress report. Office of Scientific and Technical Information (OSTI), July 1993. http://dx.doi.org/10.2172/10161252.

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Niedenzu, K., H. Noeth, J. Serwatowska, and J. Serwatowski. Diorganyltin(IV) Di-poly(1-pyrazolyl)boarates and Related Species. Fort Belvoir, VA: Defense Technical Information Center, June 1991. http://dx.doi.org/10.21236/ada236442.

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Schmidt, R. D., G. S. Lee, P. F. Pagoria, A. R. Mitchell, and R. Gilardi. Synthesis and Properties of a New Explosive, 4-Amino-3,5-Dinitro-lH-Pyrazole (LLM-116). Office of Scientific and Technical Information (OSTI), May 2001. http://dx.doi.org/10.2172/15005359.

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Wilson, Bobby L. The Study of Some Early Transition Metals in Oxidation State IV Using the Potassium Poly(pyrazolyl)borates as Ligands. Fort Belvoir, VA: Defense Technical Information Center, October 1985. http://dx.doi.org/10.21236/ada164074.

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