Relevant bibliographies by topics / Pyrazole

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  1. Journal articles
  2. Dissertations / Theses
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  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Pyrazole'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Pyrazole"

1

Abaszadeh, Mehdi, Hassan Sheibani, and Kazem Saidi. "The Condensation of (Chlorocarbonyl)phenyl Ketene with Bisnucleophiles. Synthesis of 4-Hydroxy-5-phenylpyro-[2,3-c]pyrazol-6-ones and Formation of Pyrazolo[1,2-a]pyrazole-triones by Hydrogen Exchange in Unstable Mesoionic Compounds." Australian Journal of Chemistry 63, no. 1 (2010): 92. http://dx.doi.org/10.1071/ch09344.

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The addition of (chlorocarbonyl)phenyl ketene 2 to 5-alkylpyrazol-3(4H)-ones 1 led to the formation of 3-hydroxypyrazolo[1,2-a]pyrazole-dione/pyrazolo[1,2-a]pyrazole-trione derivatives 3. This is ascribed to hydrogen exchange in initially formed unstable, mesoionic pyrazolo[1,2-a]pyrazol-4-ium-5-olates. In contrast, condensation of the same ketene with 3-alkyl-1-phenyl-2-pyrazolin-5-ones 4 afforded 4-hydroxy-3-alkyl-1,5-diphenylpyrano[2,3-c]pyrazol-6-one derivatives 5. The latter reaction provides a new and rapid route to 4-hydroxy-2-pyrones fused to pyrazole rings, in good to excellent yields.
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2

Alsayari, Abdulrhman, Abdullatif Bin Muhsinah, Yahya I. Asiri, Jaber Abdullah Alshehri, Yahia N. Mabkhot, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Mater H. Mahnashi, and Mohd Zaheen Hassan. "Arylhydrazono/Aryldiazenyl Pyrazoles: Green One-Pot Solvent-Free Synthesis and Anticancer Evaluation." Letters in Organic Chemistry 17, no. 10 (November 17, 2020): 772–78. http://dx.doi.org/10.2174/1570178617666200320104923.

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The aim of this study was to synthesize and evaluate the biological activity of pyrazole derivatives, in particular, to perform a “greener” one-pot synthesis using a solvent-free method as an alternative strategy for synthesizing hydrazono/diazenyl-pyridine-pyrazole hybrid molecules with potential anticancer activity. Effective treatment for all types of cancers is still a long way in the future due to the severe adverse drug reactions and drug resistance associated with current drugs. Therefore, there is a pressing need to develop safer and more effective anticancer agents. In this context, some hybrid analogues containing the bioactive pharmacophores viz. pyrazole, pyridine, and diazo scaffolds were synthesized by one-pot method. Herein, we describe the expedient synthesis of pyrazoles by a onepot three-component condensation of ethyl acetoacetate/acetylacetone, isoniazid, and arenediazonium salts under solvent-free conditions, and the evaluation of their cytotoxicity using a sulforhodamine B assay on three cancer cell lines. Molecular docking studies employing tyrosine kinase were also carried out to evaluate the binding mode of the pyrazole derivatives under study. 1-(4-Pyridinylcarbonyl)-3- methyl-4-(2-arylhydrazono)-2-pyrazolin-5-ones and [4-(2-aryldiazenyl)-3,5-dimethyl-1H-pyrazol-1- yl]-4-pyridinylmethanones, previously described, were prepared using an improved procedure. Among these ten products, 1-isonicotinoyl-3-methyl-4-[2-(4-nitrophenyl)hydrazono]-2-pyrazolin-5-one (1f) displayed promising anticancer activity against the MCF-7, HepG2 and HCT-116 cell lines, with an IC50 value in the range of 0.2-3.4 μM. In summary, our findings suggest that pyrazoles containing hydrazono/ diazenyl and pyridine pharmacophores constitute promising scaffolds for the development of new anticancer agents.
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Sophy, Mohamed Ahmed Elian, and Mohamed Ahmed Mahmoud Abdel Reheim. "Synthesis of Some New 1, 3, 4-Oxadiazole, Pyrazole, and Pyrimidine Bearing Thienopyrazole Moieties." Current Organic Synthesis 17, no. 8 (October 28, 2020): 661–70. http://dx.doi.org/10.2174/1570179417999200730215318.

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Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus. In the present work, pyrazol- 3-one 1 was reacted with cyanoacetic acid hydrazide and elemental sulfur to afford the corresponding thieno[3,2-c]pyrazol-6-carbohydrazide 3 derivatives. The latter compound reacted with some electrophilic reagents such as DMF-DMA, triethylorthoformate, arylidenemalononitriles and chalcones under neat conditions to give substituted oxadiazole and pyrazole, respectively. The treatment of compound 3 with active methylene reagents such as acetylacetone, diethylmalonate, ethyl acetoacetate and ethyl cyanoacetate under suitable conditions afforded pyrazole derivatives 10, 11, 13, and 15, respectively. Novel pyrazolothienopyrimidine 27 and 30 were prepared from precursor 26 with carbon disulfide and triethylorthoformate, respectively. The chemical structures of the newly synthesized compounds were established by elemental and spectral analyses including IR, and 1HNMR in addition to 13C-NMR and mass spectra. Materials and Methods: A novel substituted pyrazole, pyrimidine and pyrazolothienopyrimidine were obtained via Gewald synthesis of thiophene and fused thiophene and Mannich reactions of 5-amino-3-phenyl-1Hthieno[ 3,2-c]pyrazole-6-carbohydrazide. Results and Discussion: A series of some newly azoles and azines were prepared via reaction of thieno[3,2- c]pyrazol-6-carbohydrazide derivative 3 as starting material with some electrophilic and nucleophilic reagents. The structures of target compounds were established by elemental analyses and spectral data. Conclusion: Pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus. In the current investigation, we have developed new and efficient methods for the synthesis of thieno[3,2-c]pyrazol-6-carbohydrazide derivatives. In addition, we have explored the preparative potential of these substances as intermediates for the synthesis of substituted pyrazoles and fused pyrazoles 10-30, respectively.
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4

Hartwig de Oliveira, Daniela, Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, Ana Paula Pesarico, Diego Alves, Raquel Guimarães Jacob, and Lucielli Savegnago. "Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles." Canadian Journal of Physiology and Pharmacology 98, no. 7 (July 2020): 441–48. http://dx.doi.org/10.1139/cjpp-2019-0356.

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Pyrazoles represent a significant class of heterocyclic compounds that exhibit pharmacological properties. The present study aimed to investigate the antioxidant potential of pyrazol derivative compounds in brain of mice in vitro and the effect of pyrazol derivative compounds in the oxidative damage and toxicity parameters in mouse brain and plasma of mice. The compounds tested were 3,5-dimethyl-1-phenyl-4-(phenylselanyl)-1H-pyrazol (1a), 3,5-dimethyl-4-(phenylselanyl)-1H-pyrazole (2a), 4-((4-methoxyphenyl)selanyl)-3,5-dimethyl-1-phenyl-1H-pyrazole (3a), 4-((4-chlorophenyl)selanyl)-3,5-dimethyl-1-phenyl-1H-pyrazole (4a), 3,5-dimethyl-1-phenyl-4-(phenylthio)-1H-pyrazole (1b), 3,5-dimethyl-4-(phenylthio)-1H-pyrazole (2b), 4-((4-methoxyphenyl)thio)-3,5-dimethyl-1-phenyl-1H-pyrazole (3b), 4-((4-chlorophenyl)thio)-3,5-dimethyl-1-phenyl-1H-pyrazole (4b), and 3,5-dimethyl-1-phenyl-1H-pyrazole (1c). In vitro, 4-(arylcalcogenyl)-1H-pyrazoles, at low molecular range, reduced lipid peroxidation and reactive species in mouse brain homogenates. The compounds also presented ferric-reducing ability as well nitric oxide-scavenging activity. Especially compounds 1a, 1b, and 1c presented efficiency to 1,1-diphenyl-2-picryl-hydrazyl-scavenging activity. Compounds 1b and 1c presented 2,20 -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)-scavenging activity. In vivo assays demonstrated that compounds 1a, 1b, and 1c (300 mg/kg, intragastric, a single administration) did not cause alteration in the of δ-aminolevulinic acid dehydratase activity, an enzyme that exhibits high sensibility to prooxidants situations, in the brain, liver, and kidney of mice. Compound 1c reduced per se the lipid peroxidation in liver and brain of mice. Toxicological assays demonstrate that compounds 1a, 1b, and 1c did not present toxicity in the aspartate aminotransferase, alanine aminotransferase, urea, and creatinine levels in the plasma. In conclusion, the results demonstrated the antioxidant action of pyrazol derivative compounds in in vitro assays. Furthermore, the results showed low toxicity of compounds in in vivo assays.
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Lindsay-Scott, Peter J., and Eloise Rivlin-Derrick. "Regiocontrolled Synthesis of 6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]oxazines." Synthesis 52, no. 01 (October 8, 2019): 105–18. http://dx.doi.org/10.1055/s-0037-1610734.

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Synthetic access to 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazines has been achieved in 3–4 steps from commercially available pyrazoles. Optimization of a protected hydroxyethyl group on N1 enabled the regiocontrolled construction of pyrazole-5-aldehydes in high yields; subsequent deprotection and reduction generated fused heterocyclic scaffolds bearing multiple substitution patterns. Moreover, the intermediate pyrazole lactols were shown to be versatile synthetic building blocks.
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Andicsová, Anita, Angelika Lásiková, Marek Fronc, Jozef Kožíšek, and Daniel Végh. "3-(2-Heteroaryl)-pyrazolotetrazoles – a subunits for losartan-like structures." Acta Chimica Slovaca 5, no. 2 (November 1, 2012): 220–24. http://dx.doi.org/10.2478/v10188-012-0033-z.

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Abstract A modification of biphenylyltetrazole moiety of Losartan (A) by 3-(2-heteroaryl)-pyrazolotetrazole (B) is described. Ketone semicarbazones react with two moles of phosphorus oxychloride-dimethylformamide with the formation of 3-substituted pyrazol-4-carbaldehydes. The transformations of 3-substituted pyrazole-4- carboxaldehydes to 3-substituted pyrazole-4-nitriles were carried out by reaction of hydroxylamine in DMFA. The prepared cyano pyrazoles were converted to tetrazoles by heating with trimethylsilylazide and dibuthyltinoxide in toluene.
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Srinivasa Reddy, T., Hitesh Kulhari, V. Ganga Reddy, A. V. Subba Rao, Vipul Bansal, Ahmed Kamal, and Ravi Shukla. "Synthesis and biological evaluation of pyrazolo–triazole hybrids as cytotoxic and apoptosis inducing agents." Organic & Biomolecular Chemistry 13, no. 40 (2015): 10136–49. http://dx.doi.org/10.1039/c5ob00842e.

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A series of pyrazolo–triazole hybrids were designed and synthesized by combining the 1,3-diphenyl pyrazole and triazole scaffolds to obtain (1-benzyl-1H-1,2,3-triazol-4-yl)(1,3-diphenyl-1H-pyrazol-4-yl)methanones.
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Lerner, Hans-Wolfram, Günter Margraf, Tonia Kretz, Olav Schiemann, Jan W. Bats, Gerd Dürner, Fabrizia Fabrizi de Biani, Piero Zanello, Michael Boltea, and Matthias Wagner. "Redox Behaviour of Pyrazolyl-Substituted 1,4-Dihydroxyarenes: Formation of the Corresponding Semiquinones, Quinhydrones and Quinones." Zeitschrift für Naturforschung B 61, no. 3 (March 1, 2006): 252–64. http://dx.doi.org/10.1515/znb-2006-0304.

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Abstract Pyrazolyl-substituted 1,4-dihydroxybenzene and 1,4-dihydroxynaphthene derivatives have been synthesized by reaction of 1,4-benzoquinone and 1,4-naphthoquinone, respectively, with pyrazole. Cyclovoltammetric measurements have shown that 1,4-benzoquinone possesses the potential to oxidize 2-(pyrazol-1-yl)- and 2,5-bis(pyrazol-1-yl)-1,4-dihydroxybenzene. The 2,5-bis(pyrazol-1-yl)- 1,4-dihydroxybenzene reacts with air to give quantitatively black insoluble 2,5-bis(pyrazol-1-yl)-1,4- quinhydrone. Black crystals of 2,5-bis(pyrazol-1-yl)-1,4-quinhydrone suitable for X-ray diffraction were grown from methanol at ambient temperature (monoclinic C2/c). The poor yields of pyrazolylsubstituted 1,4-dihydroxybenzene and 1,4-dihydroxynaphthene derivatives can be explained by the formation of insoluble black quinhydrons in the reaction of benzoquinone and naphthoquinone with pyrazole. The dianions of 2-(pyrazol-1-yl)- and 2,5-bis(pyrazol-1-yl)-1,4-dihydroxybenzene react with oxygen to give the corresponding semiquinone anions. 2,5-Bis(pyrazol-1-yl)-1,4-benzoquinone shows two reversible one-electron reduction processes in cyclovoltammetric measurements, whereas pyrazolyl-substituted 1,4-dihdroxybenzene and -naphthene derivatives undergo irreversibile electrontransfer processes.
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Alsayari, Abdulrhman, Yahya I. Asiri, Abdullatif Bin Muhsinah, and Mohd Zaheen Hassan. "Anticolon Cancer Properties of Pyrazole Derivatives Acting through Xanthine Oxidase Inhibition." Journal of Oncology 2021 (July 5, 2021): 1–5. http://dx.doi.org/10.1155/2021/5691982.

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Background. Pyrazoles are an interesting class of compounds showing potent anticancer activities. Our previous studies have demonstrated the potent anticancer activity of pyrazole analogues. Therefore, we focused on developing anticancer agents through structure optimization of the pyrazolyl lead molecule. Methods. The pyrazole derivatives were prepared by the appropriate synthetic protocols. The antiproliferative activities were evaluated using a sulforhodamine B assay against three cancer cell lines. In vitro and in silico molecular docking studies employing xanthine oxidase were used to explore the mechanism by which pyrazole derivatives exert anticancer effects. Results. One of the pyrazole derivatives demonstrated the greatest promise as an anticancer agent against the human colon cancer cell line (IC50 4.2 μM), with a potent xanthine oxidase inhibitory activity (IC50 0.83 μM). Conclusion. In summary, our findings suggest that these pyrazolyl analogues containing a pyridine nucleus could serve as a promising lead molecule in the development of novel anticancer agents.
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Farooq, Saba, and Zainab Ngaini. "Chalcone Derived Pyrazole Synthesis via One-pot and Two-pot Strategies." Current Organic Chemistry 24, no. 13 (October 1, 2020): 1491–506. http://dx.doi.org/10.2174/1385272824999200714101420.

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Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal fields. Pyrazole is stable compound that is particularly used in pharmaceutical applications (i.e., anticancer, antifungal, antiviral, antimicrobial and antioxidant) and electronic industries. This review depicted the synthesis of pyrazoles derivatives by employing chalcone derivatives as a starting material via one and two-pot strategies. The one-pot strategy is an exclusive method for chalcone cyclization and oxidation, while two-pot strategy is reported through the preparation of chalcone derivatives, i.e., pyrazoline, hydrazone and bromochalcone prior to the synthesis of pyrazole. One-pot strategy is frequently reported for pyrazole synthesis purposes due to unique, stable, reactive and well-known chalcone reactants having easy handing then two-pot strategy. This review is momentous in organic chemistry, especially synthesis related to pyrazole and drug industry.
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Dissertations / Theses on the topic "Pyrazole"

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Seager, Laura Elizabeth. "Cycloaddition routes to pyrazole and pyrazoline amino acids." Thesis, Loughborough University, 2009. https://dspace.lboro.ac.uk/2134/34835.

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In recent years, the design and synthesis of structures that can potentially mimic the properties of the peptide bond have been of great interest to biological chemists. We are investigating the synthesis of novel pyrazoline-based structures as potential peptide mimetics. The pyrazoline unit is assembled by 1,3-dipolar cycloaddition of nitrile imines, which are generated in situ from hydrazonyl chlorides. We have investigated two routes to afford the hydrazonyl chloride, (1) via a hydrazone and (2) via a hydrazide, both of which have resulted in the successful synthesis of the desired pyrazolines. Subsequent syntheses have been carried out using a variety of different dipoles and dipolarophiles. We have taken approach (1) and used this to synthesize a pyrazole as one major enantiomer. This pyrazole has been subject to peptide couplings to form a complete peptide mimetic. NMR studies have been carried out on the synthesized peptide mimetic to determine the degree of hydrogen bonding and β-turn characteristics.
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Tran, Gaël. "Synthèse de phosphonylpyrazoles et de fluoropyridazines." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066414/document.

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Dans le cadre de nos travaux, nous avons développés des voies de synthèses permettant d'accéder à deux familles d'hétérocycles aromatiques: les phosphonylpyrazoles, et les fluoropyridazines. La synthèse des pyrazoles phosphonylés a été réalisée en utilisant un couplage croisé pallado-catalysé de type Hirao, et nous avons démontré qu'un système catalytique unique à base de Pd(OAc)2/XantPhos pouvait catalyser le couplage entre une large gamme d'halogénopyrazoles et de H-phosphonyles. Bien que souffrant de certaines limites dans son champ d'application, notamment au niveau du motif de substitution de l'halogénopyrazole, cette méthode consiste probablement à l'heure actuelle la voie d'accès la plus modulable pour accéder aux pyrazoles phosphonylés.Les 5-fluoropyridazines ont été synthétisées par réactions de cycloadditions séquentielles [2+1]/[3+2] entres des alcynes, le difluorocarbène :CF2, et des diazoacétates d'alkyles. Nous avons démontré que cette séquence réactionnelle était compatible avec un grand nombre d'alcynes diversement substitués, et que les 5-fluoropyridazines ainsi obtenues pouvaient être aisément fonctionnalisées
The work presented in this manuscript concerns the development of synthetic routes to two families of heterocycles, namely phosphonylpyrazoles and fluoropyridazines. Phosphonylpyrazoles were synthesized using a Hirao-type cross-coupling, and it was demonstrated during this study that a single catalytic system based on Pd(OAc)2/XantPhos could perform the cross-coupling between a wide range of halopyrazoles and H-phosphonyls. Significant limits have been met in the scope of this method, especially regarding the substitution pattern of the halopyrazole. Nevertheless, at this time, this method is arguably one of the most flexible ways to synthesize phosphonylpyrazoles. Fluoropyridazines were synthesized using a [2+1]/[3+2] cycloaddition sequence between alkynes, the difluorocarbene :CF2, and alkyl diazoacetates. It was demonstrated during this study that a wide range of alkynes could be involved in this sequence, and that the corresponding 5-fluoropyridazines could be easily diversified
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Acquah, Chris. "Syntheses and Characterization of a New Cyano-Substituted Bis(pyrazolyl)borate and its Thallium (I) Complex." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3141.

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Scorpionates are versatile and flexible ligands with a wide range of applications including catalysis, C-H bond activation, formation of new class of materials, and mimicking enzymatic reactions. This is as a result of its steric and electronic properties, and due to the relative ease with which the 3, and 5-positions of the pyrazole ring can be functionalized. In this work, we report the synthesis of a new class of scorpionate ligands known as cyanoscorpionates which can crosslink various metal centers. Thus, bis (4-cyano-3,5-diphenylpyrazolyl)borate BpPh2,4CN was synthesized and fully characterized by 1H NMR and FT-IR. Coordination of bis (4-cyano-3,5-diphenylpyrazolyl)borate BpPh2,4CN to thallium (I) metal was performed and characterized and we are looking to elucidating its molecular structure by X-ray crystallography in future.
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Ostache, Nicu-Carmin. "Synthèse et fonctionnalisation de bicycles 5-5 polyazotés : pyrazolo[3,4-d]thiazoles et pyrazolo[3,4-c]pyrazoles." Thesis, Orléans, 2019. http://intranet.univ-orleans.fr/bibliotheques/theses/nicu-cosmin-ostache_3378_vm.pdf/.

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Les structures bicycliques azotées sont parmi les entités les plus utilisées dans le domaine thérapeutique.Les bicycles 5:5 polyazotés sont des structures moins décrites que leurs analogues 6:6 ou6:5. Malgré le potentiel pharmacologique des pyrazolo [3,4-d] thiazoles et des pyrazolo [3,4-c] pyrazoles,deux exemples de ces familles rares, seuls quelques procédés de préparation et de fonctionnalisationdirecte de ces charpentes hétérocycliques sont décrits.De ce fait, l’objectif principal de nos recherches vise à développer de nouvelles voies de synthèse vers cesdeux charpentes bicycliques et ce, à partir de substrats facilement accessibles. Des stratégies efficaces ontété mises au point et s’appuient sur réactions de condensations avec des hydrazines, des N-cyclisationsintramoléculaires, des halogénations chimiosélectives et diverses réactions de couplage-croisé. De surcroît,le motif pyrazolo[3,4-d]thiazole a été fusionné à une structure triazapentalène, afin d’évaluer les propriétésspectroscopiques
Nitrogen-rich fused bicyclic structures are undisputedly one of the most used scaffolds for therapeutic use.The 5:5 polynitrogenated bicycles are moieties considerably less documented then their 6:6 or 6:5analogues. Despite the pharmacological potential of the pyrazolo[3,4-d]thiazoles and of thepyrazolo[3,4-c]pyrazoles, two examples of such rare families, only few methods of preparation and directfunctionalization of these heterocyclic moieties have been described.In this context, the main goal of our research aims at exploring new routes towards these bicyclic systemsfrom readily available and affordable starting materials. Efficient strategies were developed relying onhydrazine condensations, on intramolecular N-cyclizations, on chemo-selective halogenation and variouscross-coupling reactions. Moreover, the pyrazolo[3,4-d]thiazole entity was fused to a triazapentalenestructure in order to assess the spectroscopic properties
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Keter, Frankline Kiplangat. "Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&amp.

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The use of metallo-pharmaceuticals, such as the platinum drugs, for cancer treatment illustrates the utility of metal complexes as therapeutic agents. Platinum group metal complexes therefore offer potential as anti-tumour agents to fight cancer. This study was aimed at synthesizing and evaluating the effects of palladium(II) and platinum(II) complexes as anticancer agents.
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Lawrence, Sally. "Early transition metal complexes of pyrazole-derived ligands." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433560.

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Comas-Barceló, Júlia. "Lewis acid-promoted synthesis of pyrazole building blocks." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/15943/.

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The present work investigated copper(II)-promoted regioselective synthesis of disubstituted pyrazole scaffolds via cycloaddition reactions between sydnones and alkynes. Cu(OTf)2 has been found to mediate the formation of 1,3-pyrazoles, while Cu(OAc)2·H2O promotes the exclusive formation of the 1,4-regioisomer. Both transformations have been optimised and the scope has been explored for both reactions. A mechanistic proposal is also reported herein that has been derived from both experimental and theoretical investigations, the latter performed in collaboration with colleagues at Universidad del País Vasco (Spain). Furthermore, a catalytic variant of the synthesis of 1,4-disubstituted pyrazoles has been developed using Cu(OAc)2 supported in modified silica gel and, in collaboration with Future Chemistry Holding BV and Radboud University (the Netherlands), this methodology has been implemented under continuous flow. A directed cycloaddition of sydnones and alkynylboranes has also been developed. A range of substrates have been synthesised and subjected to cycloaddition conditions, showing that only pyridine- and quinoline-derived substrates afforded the desired pyrazole products. Mechanistic studies using NMR spectroscopy have also been carried out. Finally, the diastereoselective addition of Grignard reagents to a sydnone sulfinimine derivative has been studied, using this strategy to generate bicyclic pyrazole scaffolds containing stereogenic centres after a functionalisation-cycloaddition tandem process.
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Ainooson, Michael Kojo. "Binuclear late transition metal complexes with pyrazole based compartmental ligands: Scaffolds for cooperative organometallic transformations." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-98FC-E.

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Foz, Owen Danny. "Mono-, bi-, tri- and polynuclear complexes of pyrazole ligands." Thesis, University of Hull, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337238.

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Motson, Graham Robert. "Coordination chemistry of 3-(2'-pyridyl) pyrazole derivative ligands." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391153.

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Books on the topic "Pyrazole"

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Degtev, M. I. Fiziko-khimicheskie svoĭstva antipirina i ego proizvodnykh: Monografii︠a︡. Permʹ: Permskiĭ gos. universitet, 2010.

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Kresinski, Roman Alexander. Tris(pyrazolyl)borate complexes of Group IV metals. Birmingham: University of Birmingham, 1990.

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Wright, Sarah Margaret Anne. Vibrational energy transfer in polyatomic molecules: Collisions of highly excited pyrazine, toluene and nitrosyl cyanide with helium, argon and nitrogen. Birmingham: University of Birmingham, 2000.

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Dighe, Nachiket S., and Ravindra B. Laware. Pyrazole-Based Drug Discovery. Elsevier, 2021.

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Evans, Wynne. The synthesis and properties of selected transition metal-pyrazole complexes and their applications towards homogeneous catalysis. 1991.

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Wiley, Richard H. Pyrazoles and Reduced and Condensed Pyrazoles. Wiley & Sons, Incorporated, John, 2009.

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Wiley, Richard H., and Paul F. Wiley. Pyrazolones, Pyrazolidones, and Derivatives. Wiley & Sons, Incorporated, John, 2009.

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The World Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing an Unfused Pyrazole Ring: A 2004 Global Trade Perspective. Icon Group International, Inc., 2005.

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Parker, Philip M. The World Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing an Unfused Pyrazole Ring: A 2007 Global Trade Perspective. ICON Group International, Inc., 2006.

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Parker, Philip M. The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing an Unfused Pyrazole Ring in China. ICON Group International, Inc., 2006.

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Book chapters on the topic "Pyrazole"

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Li, Jie Jack. "Pechmann pyrazole synthesis." In Name Reactions, 275. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_216.

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Bährle-Rapp, Marina. "Dimethyl Hydroxymethyl Pyrazole." In Springer Lexikon Kosmetik und Körperpflege, 162. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_3128.

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Yamamoto, S., T. Sato, K. Morimoto, and T. Nawamaki. "New Pyrazole Sulfonylureas." In Synthesis and Chemistry of Agrochemicals III, 34–42. Washington, DC: American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch005.

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Li, Jie Jack. "Knorr pyrazole synthesis." In Name Reactions, 317–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-01053-8_139.

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Dilworth, J. R., and S. Morton. "From Pyrazole Complexes." In Inorganic Reactions and Methods, 34–36. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470145227.ch20.

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Li, Jie Jack. "Knorr pyrazole synthesis." In Name Reactions, 347–48. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_148.

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Li, Jie Jack. "Pechmann pyrazole synthesis." In Name Reactions, 304. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_227.

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Li, Jie Jack. "Knorr Pyrazole Synthesis." In Name Reactions, 298–300. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-50865-4_78.

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Niedenzu, Kurt, and Swiatoslaw Trofimenko. "Pyrazole derivatives of boron." In Topics in Current Chemistry, 1–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/3-540-15811-1_1.

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Moedritzer, Kurt, Sarah G. Allgood, Pana Charumilind, Robert D. Clark, Bruce J. Gaede, Mitchell L. Kurtzweil, Deborah A. Mischke, et al. "Novel Pyrazole Phenyl Ether Herbicides." In Synthesis and Chemistry of Agrochemicals III, 147–60. Washington, DC: American Chemical Society, 1992. http://dx.doi.org/10.1021/bk-1992-0504.ch015.

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Conference papers on the topic "Pyrazole"

1

Khan, Mohd Shahnawaz. "An expedient synthesis of some new Pyrazole, Pyrazolone, Hydrazone and Thiosemicarbazide." In The 20th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a026.

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Gondek, E., J. Niziol, A. Danel, and J. Sanetra. "Photovoltaic effect based on pyrazole derivatives." In 2009 3rd ICTON Mediterranean Winter Conference (ICTON-MW 2009). IEEE, 2009. http://dx.doi.org/10.1109/ictonmw.2009.5385546.

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Liu, Xiaobo, Shan Xu, and Yinhua Xiong. "Synthesis of 3-phenyl-1H-pyrazole Derivatives." In 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016). Paris, France: Atlantis Press, 2017. http://dx.doi.org/10.2991/emcm-16.2017.117.

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Priyanka, S., S. Sivapriya, D. Sivakumar, M. Gopalakrishnan, M. Seenivasan, and H. Manikandan. "Synthesis and DFT calculation of novel pyrazole derivatives." In INTERNATIONAL CONFERENCE ON RECENT TRENDS IN APPLIED MATHEMATICAL SCIENCES (ICRTAMS-2020). AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0063016.

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Rao, E. Nageswara, S. Sreedhar, Surya P. Tewari, G. Manoj Kumar, and S. Venugopal Rao. "CN, C2 Molecular Emissions from Pyrazole Studied Using Femtosecond LIBS." In International Conference on Fibre Optics and Photonics. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/photonics.2012.tpo.3.

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Potapov, Andrei, Nina Chernova, Tolebi Dzhienalyev, and Andrei Khlebnikov. "Synthesis of Pyrazole-Derived Dithioethers Using in situ Generation of Dithiolate-Ions." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-a010.

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Jacob K, Sony, and Swastika Ganguly. "Molecular Docking Studies of Novel Pyrazole Analogs as Possible HIV-1-RT Inhibitors." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-b033.

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Nikalje, AnnaPratima. "4,5-Dihydro-1H-Pyrazole-1-Carbaldehyde: Synthesis, Anti-Inflammatory Activity and Docking Study." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-e013.

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Srinivasu, Nulaka, K. V. V. Satyanarayana, and N. Gopala Krishna Murthy. "Structure based drug design studies on CDK2 amino pyrazole inhibitors using Autodock Tools." In 2014 Conference on IT in Business, Industry and Government (CSIBIG). IEEE, 2014. http://dx.doi.org/10.1109/csibig.2014.7056965.

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Rozada, Thiago C., Michael J. V. da Silva, Rodrigo M. Pontes, Ernani A. Basso, and Fernanda A. Rosa. "Theoretical study of the regiospecific synthesis of pyrazole-5- carboxylate from unsymmetrical enaminodiketones." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013104184411.

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Reports on the topic "Pyrazole"

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Habben, C., L. Komorowski, W. Maringgele, A. Meller, and K. Niedenzu. Reactions of Some Boron Heterocycles with Pyrazole. Fort Belvoir, VA: Defense Technical Information Center, March 1989. http://dx.doi.org/10.21236/ada205979.

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Schmidt, R. D., G. S. Lee, P. F. Pagoria, A. R. Mitchell, and R. Gilardi. Synthesis and Properties of a New Explosive, 4-Amino-3,5-Dinitro-lH-Pyrazole (LLM-116). Office of Scientific and Technical Information (OSTI), May 2001. http://dx.doi.org/10.2172/15005359.

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Theopold, K. H. [Oxidation catalysis with tris(pyrazolyl)borate metal complexes]. Office of Scientific and Technical Information (OSTI), January 1993. http://dx.doi.org/10.2172/6487292.

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Theopold, K. H. [Oxidation catalysis with tris(pyrazolyl)borate metal complexes]. Progress report. Office of Scientific and Technical Information (OSTI), July 1993. http://dx.doi.org/10.2172/10161252.

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Niedenzu, K., H. Noeth, J. Serwatowska, and J. Serwatowski. Diorganyltin(IV) Di-poly(1-pyrazolyl)boarates and Related Species. Fort Belvoir, VA: Defense Technical Information Center, June 1991. http://dx.doi.org/10.21236/ada236442.

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Wilson, Bobby L. The Study of Some Early Transition Metals in Oxidation State IV Using the Potassium Poly(pyrazolyl)borates as Ligands. Fort Belvoir, VA: Defense Technical Information Center, October 1985. http://dx.doi.org/10.21236/ada164074.

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Manson, J. L., D. Y. Villa, W. J. A. Blackmore, J. Brambleby, P. A. Goddard, and John Singleton. Low-T magnetometry study of S = 1 Q2D [Ni(pyz)2(H2O)2](BF4)2 (pyz = pyrazine). Office of Scientific and Technical Information (OSTI), February 2017. http://dx.doi.org/10.2172/1343727.

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