Dissertations / Theses on the topic 'Pups'
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Wyile, Olive Geraldine. "Assessment of grey seal pup production from counts of pups." Thesis, University of Cambridge, 1988. https://www.repository.cam.ac.uk/handle/1810/265346.
Full textCarter, Matt. "From pup to predator : ontogeny of foraging behaviour in grey seal (Halichoerus grypus) pups." Thesis, University of Plymouth, 2018. http://hdl.handle.net/10026.1/13068.
Full text章彤輝 and Tung-fai Cheung. "Maternal malnutrition: effects on growth and development of rat pups." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31236698.
Full textCheung, Tung-fai. "Maternal malnutrition : effects on growth and development of rat pups /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1971256X.
Full textTan, H. M. "The emergence of the head direction system in pre-weanling rat pups." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469477/.
Full textSkinner, John P. "Physical and behavioral development of nursing harbor seal (Phoca vitulina) pups in Maine." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/SkinnerJP2006.pdf.
Full textTrottier, Geneviève. "Macronutrient composition of maternal diet affects hypothalamic-pituitary-adrenal responsiveness in developing rat pups." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20881.
Full textTrottier, Geneviève. "Macronutrient composition of maternal diet affects hypothalamic-pituitary-adrenal responsiveness in developing rat pups." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0002/MQ44302.pdf.
Full textVerrier, Delphine. "Extreme fasting in subantartic fue seal (Arctocephalus tropicalis) pups : Physiological adaptations and ecological implications." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13197.
Full textThe objectives of my thesis were to investigate the physiological and behavioural adaptations displayed by subantarctic fur seal pups in response to the repeated extended fasts they naturally undergo throughout their period of maternal dependence. Fasting energetics, associated endocrine changes and behavioural activity were examined in order to understand the adaptive mechanisms underlying the ontogeny of extreme fasting abilities in these animals. The adoption of an efficient strategy of energy conservation, fat storage and protein sparing (with body proteins contributing to less than 2% of total energy expenditure) in response to fasting is highlighted. Among the diverse hormones measured (thyroid hormones, cortisol, insulin, glucagon and leptin), the importance of leptin in the regulation of energetic and immune homeostasis in response to changes in nutritional state and body reserves is suggested for the first time in a free-ranging mammal (apart from primates and rodents). In addition, my results show that pup resistance to fasting develops progressively with age depending upon pronounced changes in metabolic rates and body fat stores. As a consequence, maternal foraging strategy could be constrained by ontogenetic changes in pup fasting abilities in this species. Furthermore, the trade-offs imposed by the conflicting demands of growing and surviving food deprivation upon the development of diving abilities and foraging skills were also explored in order to estimate the life history cost of extreme fasting in early life and its ecological implications
Kagawa, Noriko. "Efficient production of matured oocytes and live pups from growing oocytes of adult female." Kyoto University, 2005. http://hdl.handle.net/2433/145027.
Full text0048
新制・課程博士
博士(農学)
甲第11626号
農博第1482号
新制||農||906(附属図書館)
学位論文||H17||N4019(農学部図書室)
23269
UT51-2005-D375
京都大学大学院農学研究科応用生物科学専攻
(主査)教授 久米 新一, 教授 今井 裕, 教授 廣岡 博之
学位規則第4条第1項該当
Teng, Carolyn J. "Effects of intraplantar injection of inflammatory mediators in 3 and 15 day old rat pups." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27422.
Full textThe present study has two aims: (1) to determine the behavioural indices that best measure formalin-induced pain in 3 and 15 day old rat pups, and (2) to examine the behavioural response of infant rats to intraplantar injection of single inflammatory mediators and paired combinations of mediators. In Experiment 1, ascending concentrations of formalin were injected subcutaneously into the plantar surface of one rear paw.
In Experiment 2, ascending doses of 5-HT, PGE$ sb2$, bradykinin, or substance P were injected and the measures that were quantitatively related to formalin concentration used to assess pain. The data suggest that strong responses to formalin in young neonatal rats are not only a consequence of the continuing development of brainstem-spinal inhibitory systems, but may also be due to immaturity of peripheral pain transduction mechanisms. (Abstract shortened by UMI.)
Teng, Carolyn J. "Effects of intraplantar injection of inflammatory mediators in 3 and 15 day old rat pups." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29797.pdf.
Full textMoore, Jeremy Alan. "Effects of Subcutaneous Postnatal Choline Supplementation on Hippocampus-Mediated Learning and Memory in Rat Pups." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1213369647.
Full textWeitzner, Emma. "The Development of Diving Capabilities in Weddell seal (Leptonychotes weddellii) Pups Throughout Early Ontogeny." DigitalCommons@CalPoly, 2019. https://digitalcommons.calpoly.edu/theses/2046.
Full textAlexander, Vincent Rasahd. "The Role of Corticotropin-Releasing Factor in the Behavior and Proinflammatory Activity of Separated Guinea Pig Pups." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1345847290.
Full textMacRae, Amelia. "Hand-rearing harbour seal pups (Phoca vitulina) : the effect of diet and supplementary heat on growth and survival." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/17407.
Full textSimms, Wendy Alison. "Natural and anthropogenic factors affecting the circulatory vitamin A dynamics of free-ranging harbour seal (Phoca vitulina) pups." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/MQ48205.pdf.
Full textFraissard, camille. "Experimental release of hand-reared wolf pups in Tver region (Russia): food habits, movement patterns and fear of humans." Thesis, Linköpings universitet, Zoologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68743.
Full textSørmo, Eugen Gravningen. "Organochlorine pollutants in grey seal (Halichoerus grypus) pups and their impact on plasma thyroid hormone and vitamin A concentrations." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for biologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-693.
Full textPaper I and paper IV are reprinted with kind permission of Elsevier, sciencedirect.com
Yap, Carol Sue Lynn Psychology Faculty of Science UNSW. "An analysis of late-developing learning and memory systems in rats: fear-potentiated startle and context-specific latent inhibition and extinction." Awarded by:University of New South Wales. Psychology, 2006. http://handle.unsw.edu.au/1959.4/24374.
Full textRoitt, S. M. "An investigation into the effects of lymphocyte derived soluble factors on mixed glial cell cultures from cerebra of 1-2 day old neonatal CFHB rat pups." Thesis, University of York, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235001.
Full textPedroso, Taíse Fonseca. "Avaliação da toxicidade do chumbo em parâmetros bioquímicos e comportamentais: efeito preventivo do zinco e n-acetilcisteína." Universidade Federal de Santa Maria, 2017. http://repositorio.ufsm.br/handle/1/12772.
Full textLead (Pb) is a toxic metal without biological function, which can cause various undesirable changes in organism. Developing animals are more sensitive to external aggressions, and exposure to Pb may cause pronounced and even irreversible damage. Studies show detoxifyng action by zinc chloride (ZnCl2) and N-acetylcysteine (NAC), suggesting same protective effect against intoxication with Pb. Therefore, we investigated the toxic effect of lead acetate (AcPb) on biochemical and behavioral parameters, in developing animals, and the possible protective effect of ZnCl2 and NAC. For this young Wistar rats received subcutaneously: saline, ZnCl2 (27 mg/kg), NAC (5 mg/kg) or more NAC ZnCl2 from the 3rd to 7 th; and AcPb (7 mg/kg) or saline from the 8th to 12th day of age. The animals were subjected to behavioral tasks: negative geotactismo, the tail immersion test beaker and open field to assess neurological damage and motors. They were sacrificed at 33 days and the biological samples were stored for further analysis. We assessed the body weight, the activity of porphobilinogen synthase (PBG synthase) in blood, acetylcholinesterase (AChE) in brain and cerebellum, hemoglobin (Hb) in whole blood, serum urea and creatinine, and blood, cerebrum and cerebellum levels. Pups exposed to AcPb presented a decrease of blood PBG-synthase activity, without changes in Hb content. ZnCl2 pre-exposure partially prevented the PBG-synthase inhibition. Pb caused a decrease in the activity of brain AChE, while the treatment with ZnCl2, NAC and ZnCl2 more NAC prevented this change. In addition, animals exposed to AcPb presented Pb accumulation in blood and brain; all preventive treatments decreased Pb levels. In summary, the results show that there was an accumulation of Pb and inhibition of the activity of two enzymes, which are important biomarkers of toxicity. As preventive treatments, the protector effect of ZnCl2 may related to its capacity of to induce the biosyntese of metal ligant proteins. As to NAC, it is probable that its protective effect is related to chelating effects.
O chumbo (Pb) é um metal tóxico, sem função biológica, o qual pode provocar várias alterações indesejadas no organismo. Animais em desenvolvimento apresentam maior sensibilidade à agressões externas, e a exposição ao Pb poderá provocar danos pronunciados e até mesmo irreversíveis. Alguns trabalhos sugerem que o cloreto zinco (ZnCl2) e a N-acetilcisteína (NAC) possuem ação detoxificante, podendo então, ter um efeito protetor frente a uma intoxicação com Pb. Sendo assim, buscamos investigar o efeito tóxico do acetato de chumbo (AcPb) em parâmetros bioquímicos e comportamentais, quando administrado em animais em desenvolvimento, e a possível ação protetora do ZnCl2 e da NAC sobre esta toxicidade. Para isso ratos Wistar jovens receberam subcutaneamente: salina, ZnCl2 (27 mg/kg), NAC (5 mg/kg) ou ZnCl2 mais NAC do 3o ao 7o; e AcPb (7 mg/kg) ou salina do 8o ao 12o dia de idade. Os animais foram submetidos às tarefas comportamentais: geotactismo negativo, imersão da cauda, teste do becker e campo aberto para avaliação de danos neurológicos e motores. Foram sacrificados aos 33 dias e as amostras biológicas foram guardadas para análises posteriores. Avaliou-se: o peso corporal; a atividade das enzimas porfibilinogênio-sintase (PBG-sintase) em sangue, acetilcolinesterase (AChE) em cérebro e cerebelo; níveis de hemoglobina (Hb) em sangue total, de ureia e creatinina em soro; níveis de metalotioneíanas (MT) em sangue, fígado e cérebro; dosagem de metais em sangue, cérebro e cerebelo. Filhotes expostos ao AcPb apresentaram diminuição da atividade da PBG-sintase de sangue, sem alterações no conteúdo de Hb. O ZnCl2 preveniu parcialmente a inibição PBG-sintase. O AcPb causou diminuição na atividade da AChE de cérebro, enquanto os tratamentos com ZnCl2, NAC e ZnCl2 mais NAC preveniram essa alteração. Além disso, os animais expostos ao AcPb apresentaram acúmulo de Pb em sangue e cérebro; todos os tratamentos preventivos diminuiram os níveis de Pb. Em resumo, os resultados mostram que houve um acúmulo de Pb nos tecidos onde houve inibição das enzimas, que são importantes biomarcadores de toxicidade; acredita-se que a inibição ocorra através da ligação do metal aos grupamentos tiois das enzimas. Quanto aos tratamentos preventivos, o efeito protetor do zinco pode estar ligado a indução de proteínas ligantes de metais. Ainda, sugere-se que a proteção exercida pela NAC está ligada a sua capacidade quelante.
Guilhermitti, Ana Carolina. "Comportamento de filhotes de rato (Rattus norvegicus) em um campo aberto na presença e na ausência de animais adultos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/59/59134/tde-12072011-185115/.
Full textSeveral studies with rodents allow us to analyze, among other factors, the responses of animals to novelty, emotionality and locomotion of animals. For this, several tests have been used and one of the most frequently used is the open-field. The present study aims at examining the role of the presence of an adult animal of the same species, or of a different species, in the exploratory behavior and the occupation of areas of an open-field by rat pups, tested in two conditions: grouped and individually. In the first condition, exploration tests were done in an open-field. In one wall of the open-field a cage was connected which, in different occasions, contained a female of the same species (Rattus norvegicus), a male of the same species (both unfamiliar to the pups), the dam or a female of another species, in this case, a guinea-pig (Cavia porcelus). The experimental sessions occurred at the twenty-fifth day of life of the of pups. The animals were divided into five eight-pup litters with four males and four females, which were tested together in a single session. The first group was tested in the open-field without any kind of stimulus in the cage. The other groups were tested, respectively, in the presence of the dam, another female, a male or a female guinea-pig. In the second condition, all subjects in a litter were tested under the same circumstances, but individually. The results showed that the presence of an adult animal changes the preference for the occupation of the more structured corners by rat pups in the open-field. When the animal in the cage was an adult co-specific, the tendency of the subjects was to approach the place where the adult animal was (the cage). In the presence of an animal of another species, the trend was, at first, to approach and subsequently to spent more time in the most structured corners of the open-field, areas with two walls. The animals showed behavioral differences due to grouping. The grouped pups went more often to the periphery of the open-field and spent more time in these areas than those tested individually, which, in turn, tended to be close to the adult longer than the grouped subjects. At the age they were tested, female infants were less anxious than males. In general, the main conclusion is that rat pups exposed to an open-field in the presence of an adult, exhibit a preference for the vicinity of the adult when it is a co-specific, tending to remain in the more structured areas when the cage was empty or when the animal in the cage belonged to another species.
Prigol, Marina. "Ação convulsivante do disseleneto de difenila em ratos: estudo dos mecanismos neuroquímicos e da toxicocinética." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/4418.
Full textIn recent years have been identifical numerous pharmacological properties of a selenium compound, diphenyl diselenide [(PhSe)2]. Consequently, it is important the investigation of its toxic effect for a safe application in pharmacological studies. It is known that babies, in particular, have many physiological and biochemical changes related to development, which increase the susceptibility to toxic effects of drugs. Thus, the article 1 investigated the appearance of seizure episodes induced by (PhSe)2 when administered orally at doses of 5 to 500 mg/kg in rat pups (pos natal day 12-14) and the possible glutamatergic (article 2) and GABAergic (article 3) mechanisms involved in this process. Some studies using different experimental models have demonstrated the most different pharmacological and toxicodynamics properties of (PhSe)2. However, little is known about the toxicokinetic disposition of this compound. Therefore, the aim of article 4 was to determine and quantify the plasma levels of (PhSe)2 in adult mice and rats after oral (p.o.) administration of 500 mg/kg (PhSe)2; to verify the involvement of different routes of administration, vehicle and animal species in plasma levels of (PhSe)2 and in the onset of the first seizure episode induced by it. In article 5, it was determined and quantified the levels of (PhSe)2 in plasma, liver and brain of rat pups and these levels were correlated to the latency for the onset of the first seizure episode. To obtain more information about the compound, which were to supplement the data obtained, we carried out in vitro kinetic models. The manuscript 1 investigated the drug-like properties of (PhSe)2 in regards to stability, solubility, absorption and plasma protein binding (PPB) in vitro. In manuscript 2, it was conducted an in vitro study in order to identify possible metabolic pathways responsible for the biotransformation of (PhSe)2 in the body. Results of article 1 showed that administration of (PhSe)2 caused toxicity in rat pups, evidenced by the appearance of seizures. These were dose dependent and were, at least in part, related to oxidative stress. Among the mechanisms involved in the convulsive effect of (PhSe)2 were the interaction with: glutamatergic system by stimulating the inotropic glutamatergic receptors NMDA and by inhibiting the uptake of glutamate (Article 2); GABAergic system by antagonize the GABAA receptor, stimulating GABA transaminase enzyme and increasing GABA uptake (Article 3). The article 4 revealed that the maximum concentration of (PhSe)2 in the plasma of adult rats and mice occurred 30 minutes after p.o administration of the compound and remained detectable up to 8 hours after administration. The use of different routes of administration (intraperitoneal (i.p.), p.o., subcutaneous (s.c.)) or vehicle (canola oil or dimethyl sulfoxide (DMSO)) in rats and mice indicated that the onset of the first seizure episode and plasma levels are dependent on the route of administration (i.p. > p.o. > s.c.), vehicle (DMSO > canola oil) and animal species (mouse > rat). In article 5, it was observed that rat pups showed seizures even presenting lower plasma values of (PhSe)2 as compared to adults. This result demonstrated that rat pups are more sensitive to the toxic effects of (PhSe)2 than adult rats. Levels of (PhSe)2 in the liver and brain of rat pups showed a negative correlation with the latency to the first seizure episode. The manuscript 1 showed that (PhSe)2 has chemical and biological stability. However, the compound has a low solubility in water, a high partition coefficient octanol-water and an extensive plasma protein binding. Manuscript 2 indicated that (PhSe)2 is not biotranformed by Phase I reactions, catalyzed by cytochrome P450. It reacted chemically with reduced glutathione (GSH) and N-acetylcysteine (NAC) to form adducts or reacts with protein SH groups. The presence of GSH or NAC in the incubation medium decreased the binding of (PhSe)2 protein. Finally, it was observed that (PhSe)2 reduced the activity of cytochrome P450. Together, the data presented showed that the intensity of toxic effects caused by (PhSe)2 are directly related to its toxicokinetic.
Nos últimos anos, têm sido identificadas inúmeras propriedades farmacológicas do composto de selênio disseleneto de difenila [(PhSe)2]. Assim, a pesquisa dos efeitos tóxicos deste composto torna-se importante para a segurança na aplicação farmacológica. Sabe-se que os bebês, em particular, apresentam muitas mudanças fisiológicas e bioquímicas relacionadas ao desenvolvimento, que aumentam a suscetibilidade aos efeitos tóxicos de drogas. Desta forma, no artigo 1 investigou-se o aparecimento de convulsões induzida pelo (PhSe)2, quando administrado pela via oral (p.o), nas doses de 5 à 500 mg/kg em ratos bebês (12-14 dias de vida) bem como os possíveis mecanismos glutamatérgicos (Artigo 2) e GABAérgicos (Artigo 3) envolvidos em tal processo. Vários estudos, utilizando diferentes modelos experimentais demonstraram as mais diferentes propriedades farmacológicas e toxicodinâmicas do (PhSe)2 no entanto, pouco se conhece sobre a toxicodinâmica deste composto. Por isso, o objetivo do artigo 4 foi determinar e quantificar os níveis plasmáticos de (PhSe)2 em ratos e camundongos adultos após a administração p.o. de (PhSe)2 na dose de 500 mg/kg; bem como verificar o envolvimento de diferentes vias de administração, veículos e espécie animal nos níveis plasmáticos do composto e no aparecimento de convulsões induzidas pelo mesmo. No artigo 5, determinou-se e quantificou-se os níveis de (PhSe)2 no plasma, fígado e cérebro de ratos bebês e correlacionou-se estes níveis à latência para o aparecimento de convulsões. Devido a necessidade de obter mais informações sobre o composto, que viessem a complementar os dados obtidos, realizou-se modelos cinéticos in vitro. O manuscrito 1 investigou parâmetros relacionados a estabilidade, solubilidade, absorção e ligação às proteínas plasmáticas do (PhSe)2 in vitro. No manuscrito 2 realizou-se um estudo in vitro para identificar as vias metabólicas responsáveis pela biotransformação do (PhSe)2 no organismo. Os resultados do artigo 1 demonstraram que a administração de (PhSe)2 causou toxicidade em ratos bebês, evidenciada pelo aparecimento de convulsões. Estas são dependentes da dose utilizada e estão, pelo menos em parte, relacionadas ao estresse oxidativo. Dentre os mecanismos neuroquímicos envolvidos no efeito convulsivante do (PhSe)2 estão a interação com o sistema glutamatérgico, por estimular os receptores glutamatérgicos ionotrópicos do tipo NMDA e por inibir a captação de glutamato (Artigo 2); e com o sistema GABAérgico, por antagonizar os receptores GABAégicos do tipo GABAA, estimulando a enzima GABA transaminase e estimulando a captação de GABA (Artigo 3). O artigo 4 demonstrou que concentração máxima de (PhSe)2 no plasma de ratos e camundongos adultos ocorreu 30 minutos após a administração pela via oral do composto e permaneceu detectável até 8 horas após sua administração. O uso de diferentes vias de administração (intraperitonial (i.p); p.o; subcutânea (s.c)) e veículo (óleo de canola ou dimetil sulfóxido (DMSO)) em ratos e camundongos indicou que o aparecimento de convulsões e os níveis plasmáticos de (PhSe)2 são dependentes da via de administração (i.p > p.o > s.c), do veículo (DMSO > óleo de canola) e da espécie animal (camundongo > rato). No artigo 5 observou-se ainda que os ratos bebês convulsionaram mesmo apresentando níveis plasmáticos menores de composto que os adultos, o que nos leva a crer que estes são mais sensíveis aos feitos tóxicos do (PhSe)2. Os níveis de (PhSe)2 no fígado e no cérebro de ratos bebês no momento do episódio convulsivo apresentaram uma correlação negativa com a latência para o primeiro episódio convulsivo. O manuscrito 1 revelou que o (PhSe)2 apresenta estabilidade química e biológica. No entanto, o composto apresenta uma baixa solubilidade em água, um alto coeficiente de partição octanol-água e uma extensa ligação às proteínas plasmáticas. O manuscrito 2 indicou que o (PhSe)2 não é biotransformado por reações de fase I catalizadas pelo citocromo P450. O composto reage quimicamente com a glutationa reduzida (GSH) e a N-acetilciateína (NAC), formando adutos ou ainda reage com grupos SH de proteínas. A presença de GSH ou NAC no meio de incubação diminuiu a ligação do (PhSe)2 às proteínas. Por fim, foi observado que o (PhSe)2 reduziu a atividade das enzimas do citocromo P450. Em conjunto, os resultados desta tese demonstraram que a intensidade dos efeitos tóxicos causados pelo (PhSe)2 estão diretamente relacionados a sua toxicocinética.
Mortimer, Geoffrey H. "The coil pumps." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/16296.
Full textByrd, Tommy. "Ballistic atom pumps." W&M ScholarWorks, 2015. https://scholarworks.wm.edu/etd/1539623999.
Full textBodén, Roger. "Microactuators for Powerful Pumps." Doctoral thesis, Uppsala universitet, Institutionen för teknikvetenskaper, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9402.
Full textWu, Wei-Chung. "On-chip charge pumps." Diss., Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/13451.
Full textStein, Richard J. B. "Roman wooden force pumps." Thesis, University of Reading, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444026.
Full textValdeavellano, Francisca. "Pupa: herramienta para vendimiar." Tesis, Universidad de Chile, 2006. http://www.repositorio.uchile.cl/handle/2250/100914.
Full textKöpcke, Viviana. "Conversion of Wood and Non-wood Paper-grade Pulps to Dissolving-grade Pulps." Doctoral thesis, KTH, Träkemi och massateknologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26967.
Full textQC 20101201
Oliveira, Luzia Pedroso de. "Modelos lineares mistos em estudos toxicológicos longitudinais." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/11/11134/tde-22042015-110346/.
Full textMixed models are appropriate in the analysis of longitudinal, grouped and hierarchical data, allowing describe and compare the average response profiles, taking into account the variability and correlation among the experimental units of the same group and among the values observed over the time in the same experimental unit, as well as the heterogeneity of variances. These models allow the analysis of unbalanced, incomplete or irregular data with respect to time. This work aimed to show the flexibility of linear mixed models and its importance in the analysis of longitudinal toxicological data. Linear mixed models were used to evaluate the effects of doses in the body weight gain of adult male and female Wistar rats, in repeated doses toxicity test and also the effects of pregnancy period and dose in the pups growth of treated dams. It were compared the linear mixed models of third degree polynomial regression, spline and piecewise regression, both with a single point of change in the average time of pups eyes opening, searching for the most appropriate one to describe their growth along the lactation period. The SAS/STAT codes used for exploratory data analysis, comparison and validation of fitted models are presented. It is expected that the detailing of the theory and of the applications presented contribute with the understanding, interest and use of this methodology by statisticians and researchers in the area.
Olmstead, Jennifer Anne. "Fluorescence spectroscopy of mechanical pulps." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68232.
Full textLindskog, Claes. "IC-påverkan av elektromagnetisk puls." Thesis, Linköping University, Department of Electrical Engineering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15092.
Full textDetta examensarbete undersöker effekter av en elektromagnetisk puls på IC-kretsar.
För att kunna utvärdera inverkan har ett testobjekt, innehållande komponenter som skall testas, konstruerats. Detta testobjekt består av batteri, en enkel komponent och last. Ett pulsaggregat och en antenn användes för att generera de elektromagnetiska pulser som testobjektet utsattes för. Resultaten visar att inverkan på de testade komponenterna är möjlig. Inverkan visade sig vara beroende av bl.a. avståndet till antennen och den tid som testobjektet utsätts för störning. Störning har också utförts vid olika polariseringar.
Ett mål var att kunna jämföra en elektromagnetisk störning via en antenn med en trådbunden störning, där pulsen genererats från samma pulsaggregat. Försöken att utföra trådbunden störning av testobjektet misslyckades då pulsen inte var tillräckligt bra.
Detta examensarbete är en del av en artikel, High Power Ultra Wide Band and Vircator Source-Victim Experiment, som presenterades vid konferensen EMC Europe 2008.
This paper studies the effects of an electromagnetic pulse on IC-circuits. A DUT (device under test) has been constructed so that the effects of the pulse can be evaluated. The DUT consists of a battery, a load and the component, which is to be tested. A high voltage power supply and an antenna were used to generate the pulses that the DUT were exposed to. The results show that the effects were dependent on, among others, the distance between the antenna and the DUT and the time during which the DUT was exposed to the pulse. The DUT has also been exposed to different polarisations of the pulse.
One of the objectives of the study was to compare the difference between a pulse from an antenna and from a wire. This was to be done with the same high voltage power supply. Attempts to use a wire, for injecting the pulse, were unsuccessful since the damped pulse was not satisfying.
This paper is a part of a paper, High Power Ultra Wide Band and Vircator Source-Victim Experiment, that was presented at the conference EMC Europe 2008.
Andreassen, Hanne Elisabeth Bø. "Air reversing CO2 heat pumps." Thesis, Norges Teknisk-Naturvitenskaplige Universitet, Institutt for elkraftteknikk, 2010. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-11017.
Full textCO2 is an environmentally friendly refrigerant that has a no global warming potential when used as refrigerant. The current refrigerants used for air conditioning in public transport are chemical components, and have a high global warming impact. The possibility of replacing the conventional refrigerants by CO2 is investigated for various parts of the transport sector. A possible CO2system for heating and cooling for public transport has been modeled and simulated. This system is a turntable prototype which is reversing the airflows to provide either cooling or heating. It has two gascoolers and two evaporators for separate treatment of ambient and recycled air. The plate is rotated 180˚ to switch from heating to cooling mode. CO2 has large potential for expansion work, due to the normally large throttling losses for high ambient temperatures. An ejector has therefore been implemented in the heat pump circuit. The turntable prototype is modeled by the simulation tool Modelica, and it is investigated how this ejector system adjusts to varying ambient conditions and power demand. Weather data from the climate database Meteonorm was used as a basis for calculation of heating and cooling demand for a train compartment in five different cities, covering a variety of climates. A case study was performed based on an occupancy rate profile and operative hours of the heat pump for the compartment. Simulations were performed of the air reversing heat pump based on the heating -and cooling demand calculations for the five cities. The COP values obtained are very positive, and they are in general higher for heating than cooling mode. The COP is depending on the load, and decreases with reduced occupancy rate. For cooling mode the COP ranged from 3.1 to 6. For heating mode it ranged from 8.2 to 2.8. With the occupancy rate chosen, the annual energy savings is about 80% for all the 5 cities of the study. The fan work of the heat pumps was also included for 4 different operating modes. This reduced the total COP by between 10 to 40%, depending on heating and cooling power requirement and ambient conditions. The fin and tube gas coolers that were used in the Modelica model were compared to a set of MPE gas coolers. The total mass of the heat exchangers was reduced by 50%. One would still have to weigh the reduced mass and increased LCCP performance against the increased investment cost of the MPE heat exchangers.
Zora, Betul. "Ion pumps in Drosophila hearing." Thesis, The University of Iowa, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1601119.
Full textIon pumps establish homeostasis across the membranes of living cells. Hearing is a mechanotransduction event that takes place in a closed compartment containing a fluid high in K+ concentrations. In Drosophila melanogaster, this closed compartment is formed by a scolopale cell that wraps around the dendrite of sensory neurons. The receptor lymph is maintained by the scolopale cell. The lumenal membrane of the scolopale cell is the wall of the compartment containing the receptor lymph, the scolopale space. The ablumenal membrane of the scolopale cell creates the border of the scolopidium.
The Na/K pump is located on the ablumenal membrane of the scolopale cell, bringing K+ into the scolopale cell cytoplasm and extruding K electrogenically (Roy et al., 2013). We explored other primary and secondary ion pumps that are involved in creating a K+-rich lumen in the Malpighian tubule (Day et al., 2008; Rodan et al., 2012). We used RNAi technology to knockdown one gene at a time and electrophysiology to measure a sound evoked potential (SEP) that reflects the fly’s ability to hear.
We found that knocking down V-ATPase, a proton pump, subunits involved in proton extrusion significantly reduces the SEP of knockdown flies. The involvement of cation chloride cotransporters (CCCs) and cation proton antiporter (CPAs), both secondary ion pumps that use the gradients created by the Na/K pump and V-ATPase respectively to pump other ions up their gradient, is less clear. We found that knocking down Nhe3, a CPA, significantly reduced the SEP when knocked down in the scolopale cell, suggesting it as a partner to the V-ATPase. Knocking down CG31547 statistically increased the SEP, possibly a type1 statistical error.
Davies, Daniel Gower. "Modern wind powered water pumps." Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339497.
Full textEdwards, John Mason. "Microfluidic Electro-osmotic Flow Pumps." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2145.pdf.
Full textFuxová, Zuzana. "Online marketingová strategie Grandhotelu Pupp." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-205115.
Full textWang, Longke. "Adaptive control of variable displacement pumps." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/43654.
Full textRejman, Karl, and University of Lethbridge Faculty of Arts and Science. "What puts the 'terror' in terrorism." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/232.
Full textvi, 86 leaves ; 29 cm.
Lee, Hi Sun. "Spray generation by gas-lift pumps." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61897.
Full textTomac, Tom, and n/a. "Feedback and control of micro-pumps." Swinburne University of Technology, 2006. http://adt.lib.swin.edu.au./public/adt-VSWT20070220.130359.
Full textWelch, Lorrie V. S. "Low-consistency refining of mechanical pulps." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0014/NQ38999.pdf.
Full textKrishnan, Sundar. "Improvement in bleaching of mechanical pulps." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0031/MQ65498.pdf.
Full textWiklund, Pär-Eric. "Suction dynamics of axial piston pumps /." Stockholm, 1998. http://www.lib.kth.se/abs98/wikl0511.pdf.
Full textTomac, Tom. "Feedback and control of micro-pumps." Australian Digital Thesis Program, 2006. http://adt.lib.swin.edu.au/public/adt-VSWT20070220.130359/index.html.
Full textA thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy in the school of Advanced Studies at Industrial Research Institute Swinburne, Swinburne University of Technology - 2006. Typescript. "December 2006". Includes bibliographical references (p. 233-242).
Robbie, M. J. "Regenerative pumps for aircraft fuel systems." Thesis, Cranfield University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359572.
Full textDiaz, Gómez Maqueo Pablo (Pablo Ly). "Electrospray emitters For diffusion vacuum pumps." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/67181.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 85-87).
Following similar principles as regular diffusion vacuum pumps, an electrospray emitter is set to produce a jet of charged particles that will drag air molecules out of a volume. To be a feasible concept, the emitted particles should have enough momentum to make the colliding air particles being effectively removed from the volume. Also the density of the droplets should be such that the mean free path of air molecules to electrosprayed droplets is in the order of magnitude of the testing setup. A theoretical model is developed for estimating the pumping speed and the importance of the conductivity of the working fluid is identified. Experimental results show an interesting effect. as the pressure difference between two volumes separated by an aperture, is reduced when an electrospray emitter is on. It is showed that a single emitter is expected to have a very low pump capacity, so an array of emitters is proposed as solution. This thesis also comments on the applicability of powder compression molding for the fabrication of emitter arrays. Powder compression molding consists in manufacturing the emitter array out of a plastic - metallic powder feedstock. It consists on 4 steps: (1) Mixing of feedstock, (2) Compression molding, (3) Debinding and (4) Sintering. Initial experiments on compression molding are successful in reproducing arrays of micropillars.
by Pablo Diaz Gomez Maqueo.
S.M.
Hannour, Samir. "Synthèse d'alpha-aminoacides phosphoniques énantiomériquement purs." Montpellier 2, 1995. http://www.theses.fr/1995MON20104.
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