Dissertations / Theses on the topic 'PTXs'
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Burgess, Vanessa Anne, and n/a. "Toxicology Investigations With The Pectenotoxin-2 Seco Acids." Griffith University. School of Public Health, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030905.090222.
Full textBurgess, Vanessa Anne. "Toxicology Investigations With The Pectenotoxin-2 Seco Acids." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/365382.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Public Health
Faculty of Health Sciences
Full Text
Rodriguez, Grande Beatriz. "The role of PTX3 in brain inflammation and repair." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-ptx3-in-brain-inflammation-and-repair(b80f9c46-f81b-44a0-af27-efc932a6bd38).html.
Full textIzuogu, Ginikachukwu Osagie. "Mechanisms and impact of Post-transcriptional Exon Shuffling (PTES)." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3738.
Full textSlusher, Aaron L. "COUNTERREGULATORY EFFECTS OF PTX3 ON INFLAMMATION AND CELLULAR AGING." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5287.
Full textHarvey, Thomas Grierson. "Nonlinear optics of the polydiacetylene pTS." Thesis, Heriot-Watt University, 1991. http://hdl.handle.net/10399/874.
Full textOliveira, Mirian Maria de. "O SONHO DA MORADIA DIGNA – PROGRAMA MINHA CASA MINHA VIDA - ENTIDADES GOIÂNIA DE 2009 A 2015." Pontifícia Universidade Católica de Goiás, 2017. http://tede2.pucgoias.edu.br:8080/handle/tede/3819.
Full textMade available in DSpace on 2017-10-18T18:26:47Z (GMT). No. of bitstreams: 1 MIRIAN MARIA DE OLIVEIRA.pdf: 6499507 bytes, checksum: 5d35a62404f021288b54cab9e2b6e9e5 (MD5) Previous issue date: 2017-03-29
This paper analyzes the Housing Policy in Brazil, in particular Social Interest Housing, focusing on the My House My Life Entities Program in the city of Goiânia from 2009 to 2015. How was the work of the social worker performed in the Technical Work Projects (PTTS) of the Harmonia, Jardim Botânico I and Eldorado Oeste IV Housing Settlements, built by Associations attached to Movements of Housing Movements of the State of Goiás. Families moving to their homes begin to face problems such as distance, lack of Public equipment , security and others. The struggle of entities seeking to provide decent housing for the homeless has been working according to the criteria required by the Minha Casa Minha Vida - Entities Program (PMCMV-E)
Este trabalho analisa a Política de Habitação no Brasil em especial a Habitação de Interesse Social, com foco no Programa Minha Casa Minha Vida Entidades na cidade de Goiânia nos anos de 2009 á 2015. Como foi realizado o trabalho do assistente social nos Projetos de Trabalho Técnico Social (PTTS) dos Conjuntos Habitacionais Harmonia, Jardim Botânico I e Eldorado Oeste IV construídos por Associações ligadas a Entidades dos Movimentos de Moradia do Estado de Goiás. As famílias ao mudarem para suas casas,começam a enfrentar problemas como a distância, a falta de equipamentos públicos, segurança e outros. A luta das entidades em busca de propiciar moradia digna aos sem teto, tem trabalhado de acordo com os critérios exigidos pelo Programa Minha Casa Minha Vida – Entidades (PMCMV-E).
Tremblay, Jacques. "Mécanisme d'action de PTX1, un facteur de transcription à homéodomaine." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq43040.pdf.
Full textMishra, Gaurav. "Development of Person-Person Network and Interacting PTTS in EpiSimdemics." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/64160.
Full textMaster of Science
Padrão, Ana Isabel Martins Novais. "Estudo das PTMs do citocromo c cardíaco: efeitos do envelhecimento." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/3126.
Full textOs mecanismos celulares e bioquímicos subjacentes à disfunção cardíaca associada ao envelhecimento encontram-se pouco esclarecidos e, menos compreendido é o papel do estilo de vida neste processo. No sentido de avaliar a influência do estilo de vida ao longo da vida na potencial perda de funcionalidade das proteínas cardíacas, em particular do citocromo c, utilizaram-se ratinhos C57BL/6 machos que foram sujeitos a um protocolo experimental para simular o envelhecimento sedentário e activo. Os animais foram depois sacrificados, isolaram-se as mitocôndrias do coração e procedeu-se à análise de vários parâmetros bioquímicos com o intuito de (i) avaliar a funcionalidade da cadeia respiratória mitocondrial, (ii) identificar as proteínas susceptíveis à carbonilação e/ou nitração, (iii) caracterizar as PTMs do citocromo c de coração. Os resultados obtidos sugerem a existência de uma relação entre a perda de funcionalidade mitocondrial associada ao envelhecimento e o aumento do teor de proteínas carboniladas e/ou nitradas. Como proteínas alvo destas modificações pós-traducionais (PTMs) foram identificadas várias subunidades dos complexos da fosforilação oxidativa. Pela sua importância neste sistema metabólico, analisou-se mais exaustivamente a susceptibilidade do citocromo c a PTMs resultantes de processos oxidativos e de que forma o estilo de vida regula este processo. Apesar de se ter verificado um aumento da expressão do citocromo c com o envelhecimento, o número e o tipo de PTMs identificadas por LC-MS/MS não seguiu a mesma tendência. Efectivamente, identificou-se um maior número de PTMs no citocromo c do homogeneizado total dos ratinhos jovens (12 PTMs) do que nos ratinhos velhos. Considerando o efeito do estilo de vida, verificou-se a existência nos animais activos de um maior número de resíduos de aminoácidos modificados (10 PTMs) do que nos sedentários (6 PTMs). Curiosamente, a oxidação da Met65 foi a única modificação oxidativa identificada no citocromo c da fracção mitocondrial, tendo sido observada nos ratinhos velhos sedentários. ABSTRACT: Cellular and biochemical mechanisms underlying the age-related cardiac dysfunction are not fully understood and, even less clarified is the influence of lifestyle in this process. In order to evaluate the role of lifelong lifestyle in the mitochondrial plasticity and in the potential functionality loss of cardiac proteins, in particular cytochrome c, to post-translational modifications (PTMs), C57BL/6 male mice were subjected to an experimental protocol simulating sedentary and active aging. After animal sacrifice, mitochondria from cardiac muscle were isolated and several biochemical parameters were measured (i) to evaluate the mitochondrial respiratory chain functionality, (ii) to identify the susceptible proteins to carbonylation and/or nitration, (iii) to characterize the PTMs of cardiac cytochrome c. The results suggest a link between the age-related decrease in mitochondrial functionality and the higher susceptibility of cardiac muscle proteins to oxidative damage. Indeed, we observed a significant increase in the content of carbonylated and/or nitrated proteins in old mice, being the oxidative phosphorylation subunits the most affected. Given the importance of cytochrome c as the final mobile electron carrier in this metabolic process, its susceptibility to PTMs induced by oxidative stress was characterized more exhaustively. Despite the age-induced upregulation of cytochrome c, the number of oxidative PTMs identified by LC-MS/MS was not increased. Indeed, a higher number of PTMs was identified in citochrome c from young mice total homogenate (12 PTMs) compared to old mice. Regarding the effect of lifestyle, old active mice presented more PTMs (10 PTMs) than their sedentary counterparts (6 PTMs). Interestingly, the Met65 oxidation was the only PTM identified in mitochondrial cytochrome c and only in old sedentary mice.
Larbret, Frédéric. "Impact des modifications post-traductionnelles sur la dynamique du cytosquelette." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4044.
Full textActin, microtubules, and intermediate filaments compose three major cytoskeletal structures of vertebrate cells that are characterized by highly dynamic balances between assembly and de-assembly, underlying critical cellular processes such as mitosis, architecture and movement. Consequently, cytoskeleton dysfunctions have been implicated in several pathological situations including cell transformation and metastasis. Thus, cytoskeletal networks represent major targets for the development of novel anti-cancer and anti-metastatic therapies. However, drug development is currently limited by the availability of high-throughput screening systems allowing the simultaneous monitoring of actin, microtubules and intermediate filaments dynamics in living cells. In this work, we have developed a novel screening assay of cytoskeleton dynamics based on the simultaneous recording by flow cytometry of FRET signals produced by the variation of actin, tubulin and vimentin filaments dynamics in living cells. Our novel method was employed to screen a mini-library of drugs known for their ability to interfere with post-translationnal modifications of proteins. Interestingly, our approach revealed that compounds interfering with lysine acetylation have a dramatic impact on vimentin filaments assembly and microtubules polymerization. In addition, two inhibitors (WP1130 and b-AP15) of deubiquitinating enzymes showed increase of actin polymerization. This effect was attributed to poly-ubiquitnation of Destrin, an actin binding protein. In conclusion, our FRET multiplex flow cytometry assay represents a novel effective method for the future development of new anti-cancer therapies
Hambruch, Eva. "Lipidinteraktion des peroxisomalen PTS-1 Importrezeptors Pex5p." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982341806.
Full textHanson, Eleanor. "The epigenetics (histone PTMs) of therapeutic protein production in CHO cells." Thesis, University of Sheffield, 2019. http://etheses.whiterose.ac.uk/22945/.
Full textHackbusch, Daniel [Verfasser]. "Protein-Tyrosin-Phosphatasen (PTPs) als interventionelle Zielstrukturen der Arteriogenese / Daniel Hackbusch." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071088882/34.
Full textLang, Bradley Thomas. "THE ROLE OF PTPs IN REGENERATION FAILURE FOLLOWING SPINAL CORD INJURY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417619755.
Full textFernando, Alberto de Jesus. "Desenvolvimento e implementação de um novo sistema pneumático de transferência para irradiação de materiais no reator IEA-R1." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-01062011-152554/.
Full textPneumatic Transfer Systems (PTS) are classified as mechanical equipment largely operated all over the world for transport of a huge sort of objects, samples and materials located at nearly terminals or even at separated ones. System applicability is often recognized in many activities, such as medicine (hospital settings, clinical analysis labs), industry (steel, automobiles, mining, chemical, food, construction), trading (gas station, movies, supermarkets, banks, e-commerce) and federal agencies (post services, federal courts, public enterprises). In the nuclear settings, PTS shows also a vast array of applications, being a part of radioisotope production, as well as short-lived radiopharmaceuticals, including 67 Ga, 201 Tl, 18 F and 123 I-ultra pure. Besides, PTS are also used at radioactive waste management plants and research institutes that apply neutron activation analysis (NAA). This work was directed toward the design and operation of a new PTS for the IEA-R1 nuclear research reactor settled at Instituto de Pesquisas Energéticas e Nucleares (IPEN) for NAA application. With this aim, it was calculated the charge of reactor core grid plate and sample transport testing. Neutron flux at irradiating position was determined as 3,70 ± 0,26 1012 n cm-2 s-1.
Bollard, Niall. "Characterisation of phosphotransferase systems (PTS) in Clostridium difficile." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52179/.
Full textGabanyi, Ilana. "Produção e uso da proteína de fusão VP22.Pax4 na diferenciação de células-tronco em células produtoras de insulina." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-01032011-141401/.
Full textDiabetes Mellitus type 1 (DM1) is caused by an auto-imunne destruction of the pancreatic β cells, found in the endocrine portion of the pancreas, known as pancreatic islets. These β cells are responsible production and release of insulin, a hormone which promotes glucose internalization by cells. Along with other hormones, insulin is a major regulator of blood glucose levels (glycemia). One of the therapeutical strategies used to treat DM1 is pancreatic islet transplantation. One of the major problem related to this therapy is the lack of adequate cell mass to be infused into the pacients. An attempt to solve this problem is the development of an alternative source of insulin-producing cells by differentiation of stem cells, which display this differentiating potential. Pax4 is one of the transcription factors responsibles for β cell differentiation, being essential for its proper development and maturation, therefore being a good candidate to induce stem cell differentiation into insulin producing cells in vitro. A promising alternative to avoid the alterations of the differentiated cells genome due to its undesirable effects of integrating vectors, but yet allowing the Pax4 to act in diferentiation within the cells are the proteins with a transduction domain (PTDs), which would have the ability to lead the Pax4 protein directly into the cells. The Pax4 could thus act in the nucleus and generate specific transcriptional responses. The PTDs are small peptide sequences which allow translocation of proteins across cell membranes and their internalization into target cells. One of the most commonly studied PTDs is the VP22, a product of the UL49 gene from Herpes Simplex vírus type I. Therefore, the VP22.Pax4 fusion protein would transduce Pax4 into the stem cells, thus allowing the transcription activation of certain genes by Pax4, leading to improvement in the process of stem cells differentiation into insulin-producing cells. To this end, we cloned the Pax4 cDNA from RINm5f murine insulinoma cells, constructed the pVP22.Pax4 vector and transfected this construct into CHO cells, which then produced the VP22.Pax4 fusion protein. Upon verifying that VP22 was also able to transduce proteins into stem cells, by confocal microscopy analysis, after the treatment of these cells with the fusion protein VP22.eGFP, we incorporated the fusion protein VP22.Pax4 to one of the steps of the protocol used for stem cells diferentiation into insulin producing cells in our lab, by co-culturing with CHO cells producing VP22.Pax4. We observed that the addition of Pax4 led to the formation of a higher number of insulin producing cell clusters, therefore we conclude that VP22 may be used as a tool to internalize proteins into stem cells, and that the addition of Pax4 may improves protocols seeking the production of insulin-producing cell
出口, 亜由美. "黒色系ダリアにおける花弁の黒色化機構." Kyoto University, 2016. http://hdl.handle.net/2433/215583.
Full text0048
新制・課程博士
博士(農学)
甲第19757号
農博第2153号
新制||農||1038(附属図書館)
学位論文||H28||N4973(農学部図書室)
32793
京都大学大学院農学研究科農学専攻
(主査)教授 土井 元章, 教授 奥本 裕, 准教授 田尾 龍太郎
学位規則第4条第1項該当
Schuler, Chryssa [Verfasser], and Ingo [Akademischer Betreuer] Schäfer. "Behandlung der Posttraumatischen Belastungsstörung (PTBS) bei Patienten mit Substanzabhängigkeit : Effekte eines integrativen Behandlungsprogramms in der stationären Suchtrehabilitation auf PTBS-Symptomatik, Selbstfürsorge und Lebensqualität / Chryssa Schuler ; Betreuer: Ingo Schäfer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1208002627/34.
Full textButel, Nicolas. "Caractérisation d'un complexe chromatinien impliqué dans l'inactivation post-transcriptionnelle des ARNs." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS302/document.
Full textPost-transcriptional gene silencing (PTGS) is a defense mechanism that targets invading nucleic acids from endogenous (transposons) or exogenous (pathogens, transgenes) origins. Mutations in JMJ14 and NAC52 have been retrieved from a genetic screen aiming to identify PTGS deficient mutants. JMJ14 encodes an histone demethylase targeting the bi- or tri-methylated lysine 4 of histone H3, while NAC52 encodes a transcription factor. Both act in a complex that regulates the transcription of hundreds endogenous genes. However, the function of this chromatin complex in transgene expression and in PTGS is not known. JMJ14 interacts with NAC52 but also with a guanine exchange factor of the RCC1 family. Mutations in any member of the RCC1-JMJ14-NAC52 complex reduce transgene transcription. JMJ14 binds to the transgene promoter independently of NAC52, whereas NAC52 requires JMJ14 to bind on the transcribed region. However, JMJ14 and NAC52 do not seem to be required for transcription itself. Indeed, a wild-type level of transcription is restored in the jmj14 drm2 double mutant, suggesting that the complex RCC1-JMJ14-NAC52 prevents de novo DNA methylation of the promoter by DRM2. The effects of jmj14 and nac52 mutations on transgene transcription cannot explain their specific effect on some forms of PTGS. Indeed, jmj14 and nac52 do not affect constitutively-induced PTGS, but prevent the systemic spreading of locally-induced PTGS. Mutations in SCPL45, encoding a Serine-Carboxy Peptidase-Like that interacts with NAC52, but not JMJ14, have the same effect. In contrast, rcc1 does not affect the systemic PTGS, suggesting that a JMJ14-NAC52-SCPL45 complex is involved in the control of systemic PTGS. This complex could act directly on transgene chromatin to trigger PTGS in response to the PTGS signal, or indirectly by controlling the expression of an endogenous gene encoding a protein regulating systemic PTGS. To better understand the function of JMJ14 in systemic PTGS, a genetic screen aiming to identify suppressors of jmj14 have been performed. Sixteen mutants corresponding to seven genes encoding proteins related to chromatin and having an antagonist function to JMJ14, have been characterized. Mutations in theses seven genes could suppress jmj14 by increasing transgene transcription and consequently the quantity of the PTGS systemic signal. A seventeenth mutant could have a qualitative effect on the PTGS systemic signal or could affect the perception of this signal in recipient cells. The corresponding gene remains to identify
Prasad, Dipti. "The role of the TAM family of receptor PTKs in retinal homeostasis." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3204580.
Full textTitle from first page of PDF file (viewed April 4, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 110-125).
Staudt, Anke [Verfasser], and Bernd [Akademischer Betreuer] Kaspers. "Charakterisierung des langen Pentraxins PTX3 beim Huhn / Anke Staudt ; Betreuer: Bernd Kaspers." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1141053748/34.
Full textDehlawi, Saad Mohammad Abid. "Application of CaSx for the complexation of PTEs in soils and waters." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=202756.
Full textElom, Nwabueze. "Human health risk assessment of potentially toxic elements (PTEs) from environmental matrices." Thesis, Northumbria University, 2012. http://nrl.northumbria.ac.uk/15594/.
Full textPierson, Alison. "Rôle des Pioneer Translation Products (PTPs) dans la réponse immunitaire anti-tumorale." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS446/document.
Full textAnti-tumoral therapeutic vaccines rely on the activation of the adaptative immune system and are based on the recognition of tumor antigens (TA) by specific helper and cytotoxic T lymphocytes (CTL). Their efficacy requires a careful selection of the targeted antigens as well as an unaltered MHC class I (MHC-I) antigenic presentation in tumors. While the focus was first put on exome-derived TA, evidences highlighted the ones derived from alternative translations as having a high potential as T-cells targets. These can be derived from translation of allegedly non coding sequences, initiated at alternative codons or performed in non-canonical open reading frames. Such an alternative translation occurring from pre-spliced mRNAs in the nucleus has been described as giving rise to the Pioneer Translation Products (PTPs), which constitute a source of polypeptides for the MHC-I pathway. Recently, we showed that PTPs-derived antigens presented by tumors are able to elicit a CTL response in vivo that controls tumor growth. Here, we identified one positive modulator of PTPs-derived antigenic presentation in cancer cells: the splicing inhibitor isoginkgetin. Then, we provided one of its derivatives, the IP2, which is water soluble and less toxic than the isoginkgetin, and showed that IP2 treatment increases PTPs-derived antigenic presentation of cancer cells in vitro and reduces tumor growth in vivo in an immune-dependent manner. Hence we describe here the IP2 as a new efficient immunomodulator of the antitumor response, promising for the development of innovative therapeutic strategies
Brokx, Stephen John. "Structure and function of enzyme I of the PTS." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0029/NQ63848.pdf.
Full textAtkinson, Allen Bradley Jr. "A Model for the PTX Properties of H2O-NaCl." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/34376.
Full textA statistical model that relates the vapor pressure of H2O-NaCl to the fluid temperature and composition has been developed. The model consists of equations that predict the vapor pressure of H2O-NaCl from the eutectic temperature (-21.2°C) to 1500°C and for all compositions between the pure end-members. The model calculates the vapor pressure based on the composition (wt% NaCl) and the temperature of homogenization, which can be directly obtained from laboratory studies of fluid inclusions. This information in turn can be used to construct the isochore, or line of constant volume, along which the fluid inclusion was trapped. Finally the isochore can be used to determine the temperature and pressure at which the host mineral of the fluid inclusion was trapped.
Master of Science
Goletto, Valérie. "Synthèse et caractérisation d'organosilices mésostructurées à porosité périodique." Paris 6, 2002. http://www.theses.fr/2002PA066490.
Full textRoemmele, Christoph Frieder. "Zur Rolle des langen Pentraxins PTX3 in der Pathogenese des Systemischen Lupus Erythematodes." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-170024.
Full textScholbach, Johanna. "Induktion einer Endotoxämie in der humanisierten Maus." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-197083.
Full textWinterhagen, Patrick. "Entwicklung von "screening"-Methoden zur Analyse von PTGS-basierter Resistenz gegen Nepoviren in Pflanzen." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-1609.
Full textMazin, Asim Mohamed. "REDUCING THE PEAK TO AVERAGE POWER RATIO OF MIMO-OFDM USING Particle SWARM OPTIMIZATION BASED PTS." OpenSIUC, 2013. https://opensiuc.lib.siu.edu/theses/1130.
Full textBourque, Kyle P. "Combat-Related Stress, Cohesion, Coping, and Perceived Threat: Predictors and Moderators of Posttraumatic Symptomatology Among Deployed U.S. Army Soldiers." Thesis, Boston College, 2012. http://hdl.handle.net/2345/2974.
Full textThis study examined the roles cohesion, coping, and perceived threat have in buffering the effect of war-zone stress on mental health symptoms. Specifically, six factors were tested as potential moderators of the relationship between combat-related stressors and posttraumatic stress symptomatology (PTSS), including horizontal (peer) cohesion, vertical (NCO) cohesion, vertical (officer) cohesion, problem-focused coping, emotion-focused coping, and perceived threat. In addition, direct effects and curvilinear interaction effects were examined. This study was a secondary analysis of Mental Health Advisory Team (MHAT) VI data collected by military researchers as part of an ongoing effort to assess soldiers' behavioral health. This study analyzed data from a total of 1,824 male and female U.S. Army soldiers from 15 active-duty brigades who anonymously completed the Walter Reed Army Institute of Research (WRAIR) Deployment Well-Being Survey during their deployment to Iraq in support of Operation Iraqi Freedom (OIF). PTSS, combat-related stressors, horizontal (peer) cohesion, vertical (NCO) cohesion, vertical (officer) cohesion, problem-focused coping, emotion-focused coping, and perceived threat were measured. Hierarchical multiple regression analysis was used to identify both risk factors and protective factors for PTSS. The analysis revealed three risk factors and four protective factors. During a war-zone deployment, higher levels of combat-related stressors, problem-focused coping, and perceived threat (i.e., risk factors) were independently associated with greater report of PTSS. Higher levels of horizontal (peer) cohesion, vertical (NCO) cohesion, vertical (officer) cohesion, and emotion-focused coping (i.e., protective factors) were independently associated with decreased levels of PTSS. Hierarchical moderated multiple regression analysis indicated that vertical (NCO) cohesion, vertical (officer) cohesion, and emotion-focused coping buffered the effect of combat-related stressors on PTSS; soldiers higher in vertical (NCO) cohesion, vertical (officer) cohesion, and emotion-focused coping showed weaker relationships between combat-related stressors and PTSS. No support for curvilinear interaction effects were found, suggesting that for this population of soldiers deployed to Iraq, the moderating effect of vertical cohesion and emotion-focused coping on the relationship between combat-related stressors and PTSS is linear in nature
Thesis (PhD) — Boston College, 2012
Submitted to: Boston College. Graduate School of Social Work
Discipline: Social Work
Fischer, Beth Ann. "A PROSPECTIVE EXAMINATION OF URINARY STRESS HORMONES AND PTSD SYMPTOMS FROM MOTOR VEHICLE ACCIDENT TO POST-TRAUMA RECOVERY." Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1194966805.
Full textSchmitz, Benjamin P. Schmitz. "Post Translational Modifications and How to Use Them." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1524585691186704.
Full textFacemire, Vanessa Caitlynn Facemire. "Understanding the Insidious Trauma of Racism: An Exploration of the Impact of Racial Socialization, Gender, and Type of Racist Experiences." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1525285448114384.
Full textCOSTA, Elias Cardoso da. "Caracterização do material particulado inalável na atmosfera e na vegetação urbana na cidade de Goiânia." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/614.
Full textThis work had as objective to study the thin particulate material (PM2;5), thick (PM10) suspended in the atmosphere and the PTS adsorved in the vegetation s foliage of the Goiânia city and also study the metals associated with these particulates, especially Pb and Cd, giving subsidies to the city s air quality avaliation. The samples were studied between june of 2010 to june of 2011, using samplers of the type stacker which collects the thin and thick particulate simultaneously in polycarbonate membranes of 47 mm of diameter and pores of 0.4 and 8µm of diameter. The particulates masses were determinated by gravimetria and the metals analysis were done by the Atomic Espectrometry of Absortion(AEA). The thin and thick particulates concentrations showed seasonal variation with a reduction of 80% in the rainy season. The primary standard in the CONAMA resolution, of 150µg.m-³,was not exceeded in any sampled day.The ideal annual average, of 50µg.m-³, was exceeded sometimes during this period and the air quality ranged between goot to regular during the drought season and good during the rainy season. The thin particulate concentrations were above the USEPA s recommended limit in the drought season.The concentrations of the metals associated to the particulate, like Pb, Cu, Cr, Mn and Ni were below the USEPA s and WHO s concentrations. The Cd concentrations, in some samples, were above the WHO s recommended limit. The studied vegetation showed a great adsortion capacity of PTS on their foliage and reached the maximum concentration of 16,97 mg.mm-² on the Monguba s foliage and contributed to the air quality.The species which showed the biggest particulate adsorption capacity per unit of area was Oiti, followed by Monguba.OBS: Estão subscritos 2,5 e 10 em PM. O programa não copia algumas formatações.
Este trabalho teve como objetivo estudar o material particulado fino (MP2,5), grosso (MP10) em suspensão na atmosfera e o PTS adsorvidos em folhagem de vegetação da cidade de Goiânia e bem como os metais associados a esses particulados, principalmente Pb e Cd, dando subsídios para a avaliação da qualidade do ar na cidade. As amostragens foram realizadas entre Junho de 2010 e Junho de 2011, utilizandose amostrador tipo stacker que coleta o particulado fino e grosso simultaneamente em membranas de policarbonato de 47mmde diâmetro e com diâmetros de poros de 0.4 e 8µm. As massas de particulados foram determinadas por gravimetria e as análises de metais foram realizadas empregando-se a técnica da Espectrometria de Absorção Atômica (AAS). As concentrações de particulados finos e grossos apresentaram variação sazonal com uma redução de 80% no período chuvoso. O padrão primário previsto na resolução CONAMA, de 150 µg.m-³, não foi ultrapassado em nenhum dia amostrado. O valor médio anual ideal, de 50 µg.m-³, foi ultrapassado algumas vezes nesse período e a qualidade do ar variou de boa a regular no período de seca e boa durante o período chuvoso. As concentrações de particulado fino ficaram acima do limite recomendado pelo USEPA no período seco. As concentrações de metais associados ao particulado, tais como, Pb, Cu, Cr, Mn e Ni ficaram abaixo do limite recomendado pela USEPA e OMS. As concentrações de Cd, em algumas amostras, ficaram acima do limite recomendado pela OMS. A vegetação estudada apresentou grande capacidade de adsorção de PTS em suas folhagens e alcançou uma concentração máxima de 16,97 mg.mm-² em folha de Monguba e contribui na melhoria da qualidade do ar. A espécie que apresentou maior capacidade de adsorção de particulado por unidade de área foi o Oiti, seguido pela Monguba. OBS: Estão subscritos 2,5 e 10 em PM. O programa não copia algumas formatações.
Semer, Maryssa. "Le facteur de réparation XPC est un cofacteur de l'ARN polymérase II régulant les modifications post-traductionnelles des histones lors de la transcription." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ040/document.
Full textNER involves a cascade of protein complexes including the DNA damage sensor (XPC/HR23B). Mutations in NER genes (TTD-A, XPA-G, XPV, CSA and CSB) are associated with human genetic diseases including Xeroderma pigmentosum (XP), Trichothiodystrophy (TTD) and Cockayne Syndrome (CS). All the symptoms can only be explained by a defect of the DNA repair. However all the symptoms can only be explained by a defect of the DNA repair. However, it has been proven that NER factors are also involved in transcription. As the genomic scale to better understand the consequences of its deregulation in a pathological context. In this sense, my second goal has been to characterize at the molecular level the etiology of new XP patients by analyzing in a combined way the molecular events of the NER and the transcription associated with XPC. Our different experimental approaches have made it possible to identify at genomic level a set of gene whose promoters are regulated both positively and negatively by XPC in a dependent RAR context. In addition, we show that XPC interacts with KAT2A contained in the ATAC complex, as well as with the transcription factor E2F1, the chromatin remodeling factor BRD2, and the histone variant H2A.Z. Via KAT2A, this complex will acetylate not only H2A.Z but also H3K9 at promoters targeted by E2F1
Koch, Sandro. "Electrical and optical properties of hydrogen-related complexes and their interplay in ZnO." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-187905.
Full textDer kommerzielle Durchbruch von ZnO-basierten Bauelementen ist hauptsächlich durch die beständige n-Typ Leitung des Materials eingeschränkt. Wasserstoff, der sowohl elektrisch aktive als auch inaktive Komplexe in ZnO formt, gilt als ein Hauptverursacher dieses Verhaltens. Jedoch ist die bestehende Literatur zu derartigen Defekten unvollständig, teils auch widersprüchlich. Gegenstand der vorliegenden Arbeit sind umfassende Untersuchungen der beiden wasserstoffinduzierten Donatoren HBC und HO, des Wasserstoffmoleküls H2 und eines Wasserstoffdefekts mit lokalen Schwingungsmoden (LSMn) bei 3303 und 3320 cm-1 in ZnO hinsichtlich ihrer Eigenschaften und gegenseitigen Wechselwirkung. Die Charakterisierung der Komplexe erfolgt mit Hilfe von Raman-Spektroskopie, Infrarot-Absorptionsspektroskopie, Photoleitfähigkeits- (PC) und Photolumineszenzmessungen. Basierend auf der PC Technik wird eine neuartige, hochsensitive Spektroskopiemethode etabliert, welche auch in stark absorbierenden Spektralbereichen anwendbar ist. Diese Technik ermöglicht erstmals die Detektion der LSMn von HO bei 742 und 792 cm-1 im neutralen Ladungszustand. Das experimentelle Ergebnis verifiziert theoretische Vorhersagen zur mikroskopischen Struktur dieses flachen Donators. In Raman-Messungen wird der elektrische 1s→2s Übergang von HO bei 273 cm-1 identifiziert und eine Blauverschiebung dieser Größe mit zunehmender HO-Konzentration beobachtet. Der Donator HBC zeigt ebenfalls eine Blauverschiebung des elektrischen 1s→2s(2p) Übergangs, welche durch lokale Gitterverzerrungen nach Hochtemperaturbehandlungen bedingt ist. Eine Raman-Studie charakterisiert das H2-Molekül in Bezug auf seine Bildung, Stabilität, Gitterposition und die Wechselwirkung mit dem ZnO-Kristall. Insbesondere wird seine Rolle für die fortwährende Bildung der Donatoren HO und HBC und des damit verbundenen n-Typ Verhaltens herausgearbeitet. Die Analyse ergibt die eindeutige Identifizierung der in der Literatur mit „hidden hydrogen“ bezeichneten Spezies als H2. Darüber hinaus tragen die beobachteten Umwandlungsprozesse zwischen ortho-H2 und para-H2 sowie die Kopplung an das Phononenspektrum zu einem generellen Verständnis von Wasserstoffmolekülen in Halbleitern bei. Die experimentellen Ergebnisse der LSMn bei 3303 und 3320 cm-1 in Kombination mit Modellrechnungen ergeben einen zugrundeliegenden Defekt mit drei Wasserstoffatomen. Dieser Komplex Y–H3 weist zwei Konfigurationen auf, welche sich durch die Orientierung von nur einer chemischen Bindung unterscheiden. Die Beobachtungen sind mit einer Zinkvakanz besetzt mit drei Wasserstoffatomen bzw. einem Ammoniakmolekül als mikroskopische Struktur gleichermaßen erklärbar. Bisherige Modelle aus der Literatur können damit widerlegt werden. Messungen von Konzentrationsprofilen mit Raman-Spektroskopie offenbaren die lokale Verteilung der Wasserstoffdefekte sowie von Gitterstörungen. An der Oberfläche, im Beisein von Sauerstoffvakanzen, ist HO der dominante flache Donator. In dem sich anschließenden ungestörten Kristallverbund ist hingegen der Donator HBC vorherrschend. In Zentrum, welches von Zinkvakanzen geprägt ist, sind die Konzentrationen von H2 und Y–H3 maximal. In Verbindung mit Temperaturbehandlungen ist eine räumlich aufgelöste Untersuchung der Wechselwirkung möglich
Young, Chris 1981. "NMR studies if the Galactitol-specific PTS proteins IIA and IIB." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98525.
Full textBara, Mourad. "Etude par spectroscopie et Diffusion des neutrons du pFBS et pTS." Paris 7, 1985. http://www.theses.fr/1985PA07F127.
Full textDias, Mara Regina [UNESP]. "A atuação do assistente social como educador ambiental nos Projetos de Trabalho Técnico Social (PTTS)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/98602.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
As questões ambientais vem conquistando cada vez mais espaço na agenda pública e é mais visível nos diversos setores da sociedade civil. Os desafios propostos pela globalização provocam a necessidade de se ampliar as reflexões multidisciplinares, exigindo maior atenção à problemática socioambiental. Percebemos que a preocupação pela preservação do meio ambiente vem aumentando e já atinge diversos setores da sociedade, embora sejam limitadas, tendo muito a ser feito. Dentro destas reflexões e atuações multidisciplinares, encontramos a oportunidade de atuação do Serviço Social, pois preservação do meio ambiente é um tema relacionado ao trabalho do Assistente Social, uma vez que a garantia da qualidade de vida e dos direitos básicos das populações depende diretamente da qualidade do meio ambiente em que elas estão inseridas. A partir desse pressuposto apresentamos a educação ambiental como uma nova demanda ocupacional para o Assistente Social, procurando refletir acerca da intervenção deste profissional. Desta forma abordamos na dissertação a pertinência e necessária atuação dos profissionais de Serviço Social no espaço criado pelo Governo Federal, e operacionalizado pela Caixa Econômica Federal, através dos Projetos de Trabalho Técnico Social (PTTS), onde paralelo as obras físicas dos programas de desenvolvimento urbano, contam com a prestação de serviços dos assistentes sociais, que em suas atividades trabalham diversos ações como: mobilização e organização comunitária, por meio de processo educativo trabalham temas de educação ambiental e sanitária, e de geração de trabalho e renda. Enfocaremos as experiências dos trabalhos dos assistentes sociais realizados em cidades na região de Piracicaba/SP
Environmental issues have been gaining more space on the public agenda and have become more visible in the various sectors of civil society. The challenges posed by globalization cause the need to broaden the multidisciplinary reflections thus, requiring greater attention to the socio-environmental problems. We noticed that the concern for preserving the environment is increasing and already affects many sectors of society. Within these reflections and disciplinary actions we found the opportunity for the work of Social Services. Preserving the environment is an issue related to the work of the social worker, this is because the guarantee of quality of life and basic rights of the population depends on the quality the population’s environment. From this assumption we introduce environmental education as a new demand from the occupational social worker, trying to reflect on this professional intervention. Therefore we discuss the relevance of the dissertation and the necessary work of professional social work in the space created by the Federal Government and operated by the Caixa Economica Federal, through the Technical Working Projects Social – PTTs. This program, which parallels the physical work of urban development programs, relies on the services of social workers who work on various activities such as: mobilization and community organization, educational process promoting themes of environmental education and health, and employment and income generation. We focus on the experiences of work done by social workers in cities located in the region of Piracicaba/SP
Haas, Julienne [Verfasser]. "Wirksamkeit psychotherapeutischer und pharmakologischer Verfahren bei Patienten mit PTBS und komorbider psychischer Erkrankung / Julienne Haas." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/122628907X/34.
Full textNagy, Jeffrey Howard. "The relationship between military training, combat exposure, PTSS and functioning in post-9/11 veterans." Thesis, Trident University International, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10239371.
Full textThe Global War on Terror has routinely exposed military personnel to PTSD qualifying traumatic events. Scant research has included a military training and occupational context among combat Veteran populations who leave military service. This retrospective cohort study explored the influence of pre-exposure training on the relationship between combat exposure, posttraumatic stress symptoms (PTSS) and functioning impairments after discharge from military service. The results confirmed an occupational associated exposure risk for approximately 15% of the US military. Despite the combative specialty Veteran experiencing more combat in frequency and intensity, there were no differences in PTSS or functioning impairment any time after discharge or within the last thirty days between occupational cohorts. The study concluded that combative occupational training is protective against the effects of battle exposure experiences, but not post battle experiences. The study results suggest that military organizational resilience training is not effective in bolstering hardiness after discharge and transitioning into the civilian population. These findings support the creation of a military occupational mental health model for future PTSD diagnosis and treatment for combat Veteran populations.
Gifoni, Markus Andret Cavalcante. "Envolvimento da pentraxina 3 (PTX3) na patogÃnese da cistite hemorrÃgica induzida por ifosfamida em camundongos." Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1245.
Full textA cistite hemorrÃgica (CH) à um fenÃmeno inflamatÃrio frequentemente associado à quimioterapia com oxazafosforinas. Trata-se de uma resposta inflamatÃria inata à aÃÃo da AcroleÃna (ACR), metabÃlito hepÃtico comum à Ifosfamida (IFO) e à ciclofosfamida (CTX). O papel da resposta ao recrutamento de receptores toll-like (TLR) e do estÃmulo por TNF-α e IL-1β com envolvimentto de iNOS e COX-2 tem sido demonstrado neste fenÃmeno. Estudos recentes demonstram que a Pentraxina 3 (PTX3) assume papel de mediador inflamatÃrio em modelos de resposta inflamatÃria inata in vivo, sobretudo relacionada ao recrutamento de TLR. Desta forma, o presente estudo pretende investigar o possÃvel envolvimento de PTX3 na patogÃnese da CH induzida por ifosfamida em camundongos. Para isso, foi realizada quantificaÃÃo de RNAm por RT-PCR para PTX3 e IL-1β em camundongos C57/ BL6 tratados com ifosfamida e salina. Em seguida, o modelo experimental da CH induzida por ifosfamida foi reproduzido em grupos de camundongos com hiperexpressÃo e nocauteados para PTX3 em comparaÃÃo com os respectivos controles do tipo selvagem e com grupos controle tratados com salina para posterior obtenÃÃo dos pesos vesicais Ãmidos (PVU), realizaÃÃo de anÃlise histomorfomÃtrica, imunohistoquÃmica e quantificaÃÃo de RNAm por RT-PCR para PTX3, IL-1β, TNF-α e iNOS. Os animais transgÃnicos e seus controles foram sacrificados com tempos de 3h e 12h apÃs o tratamento, enquanto os nocauteados e seus controles foram sacrificados com 12 horas do tratamento. Finalmente, a CH em animais C57/ BL6 foi modulada com o prÃ-tratamento com Talidomida, Pentoxifilina, MESNA, Amifostina e Aminoguanidina para a posterior marcaÃÃo imunohistoquÃmica com PTX3, IL-1β, TNF-α e iNOS. Observou-se que o RNAm de PTX3 està cerca de 70 vezes mais expresso em animais com CH, contra uma razÃo de expressÃo de 10 para IL-1β. Animais trangÃnicos para PTX3 tÃm reduÃÃo inicial da resposta inflamatÃria com expressÃo inferior de PTX3 e TNF-α e expressÃo aumentada de iNOS e intensificaÃÃo da inflamaÃÃo ao tempo de 12 horas, com expressÃo superior dos mediadores. NÃo houve diferenÃas significativas de intensidade da CH em animais KO em relaÃÃo aos controles. A modulaÃÃo da CH por talidomida e MESNA produziu reduÃÃo importante sobre a expressÃo de PTX3, enquanto a inibiÃÃo da CH por amifostina nÃo teve reduÃÃo expressiva da pentraxina. Em conjunto, estes dados apontam para um envolvimento inequÃvoco de PTX3 na fisiopatologia da inflamaÃÃo inata em modelo de CH murino com Ãntima relaÃÃo coma expressÃo de TNF-α
The Hemorrhagic Cystitis (HC) is an inflammatory reaction usually associated with Cancer Chemotherapy with Oxazaphosphorines. It is an innate inflammatory response to vesical irritation by Acrolein, an hepatic metabolite of the treatment with Iphosphamide and Cyclophosphamide. The role of toll-like receptor (TLR) engagement and TNF-α and IL-1β expression and the involvement of iNOS and COX-2 in the pathogenesis has been well demonstrated in a murine model of HC. Recent data configure pentraxin 3 (PTX3) as an inflammatory mediator in several experimental models of innate immune response in vivo, with a straight relation with TLR engagement. Because of that, this study looks at the involvement of PTX3 in the pathogenesis of iphosphamideâinduced HC in mice. For this purpose, the mRNA to PTX3 and IL-1β t was quantified by RT-PCR in groups of C57BL6 mice treated with Iphosphamide or Saline. After that, groups of transgenic and Knock-Out mice to PTX3 and its respectives wild-type controls were treated with Iphosphamide or saline with intention to measure the Bladder Wet Weight (BWW), histomorphometric scores and Immunohistochemistry and RT-PCR to PTX3, IL-1β, TNF-α e iNOS analysis. The transgenic mice and its controls were killed in 3h and 12h after the treatment, while the PTX3 KO and its controls were killed after 12 hours. Finally, the experimental HC was modulated by pretreatment with Talidomide, Pentoxiphiline, MESNA, Amifostine and Aminoguanidine and the bladders submitted to immunohistochemistry assay (PTX3, TNF-α, IL-1β and iNOS). By RT-PCR quantification, mRNA for PTX3 was expressed 70 times more in mice treated with iphosphamide than in controls, while IL-1β RNAm had an expression rate of 10 times. PTX3 transgenic mice had initial reduction of the inflammatory response with less expression of PTX3 and TNF-α and greater expression of iNOS. In the other hand, after 12 hours, the PTX3 transgenic mice had more inflammatory signs with superior expression of all the mediators. There was no difference between the PTX3 KO mice and its controls in the HC intensity although differences between groups were seen in cytokines expression. Talidomide and MESNA produced substantial reduction on the PTX3 expression, the same was seen to TNF-α, while the amifostine marked inhibition of HC had low effect on PTX3 expression. These data as a whole, point to an unequivocal involvement of PTX3 in the pathogenesis of innate inflammatory response of HC in mice with close relation with TNF-α engagement
Dias, Mara Regina. "A atuação do assistente social como educador ambiental nos Projetos de Trabalho Técnico Social (PTTS) /." Franca, 2012. http://hdl.handle.net/11449/98602.
Full textBanca: Ana Tereza Caceres Cortez
Banca: Helen Barbosa Raiz Engler
Resumo: As questões ambientais vem conquistando cada vez mais espaço na agenda pública e é mais visível nos diversos setores da sociedade civil. Os desafios propostos pela globalização provocam a necessidade de se ampliar as reflexões multidisciplinares, exigindo maior atenção à problemática socioambiental. Percebemos que a preocupação pela preservação do meio ambiente vem aumentando e já atinge diversos setores da sociedade, embora sejam limitadas, tendo muito a ser feito. Dentro destas reflexões e atuações multidisciplinares, encontramos a oportunidade de atuação do Serviço Social, pois preservação do meio ambiente é um tema relacionado ao trabalho do Assistente Social, uma vez que a garantia da qualidade de vida e dos direitos básicos das populações depende diretamente da qualidade do meio ambiente em que elas estão inseridas. A partir desse pressuposto apresentamos a educação ambiental como uma nova demanda ocupacional para o Assistente Social, procurando refletir acerca da intervenção deste profissional. Desta forma abordamos na dissertação a pertinência e necessária atuação dos profissionais de Serviço Social no espaço criado pelo Governo Federal, e operacionalizado pela Caixa Econômica Federal, através dos Projetos de Trabalho Técnico Social (PTTS), onde paralelo as obras físicas dos programas de desenvolvimento urbano, contam com a prestação de serviços dos assistentes sociais, que em suas atividades trabalham diversos ações como: mobilização e organização comunitária, por meio de processo educativo trabalham temas de educação ambiental e sanitária, e de geração de trabalho e renda. Enfocaremos as experiências dos trabalhos dos assistentes sociais realizados em cidades na região de Piracicaba/SP
Abstract: Environmental issues have been gaining more space on the public agenda and have become more visible in the various sectors of civil society. The challenges posed by globalization cause the need to broaden the multidisciplinary reflections thus, requiring greater attention to the socio-environmental problems. We noticed that the concern for preserving the environment is increasing and already affects many sectors of society. Within these reflections and disciplinary actions we found the opportunity for the work of Social Services. Preserving the environment is an issue related to the work of the social worker, this is because the guarantee of quality of life and basic rights of the population depends on the quality the population's environment. From this assumption we introduce environmental education as a new demand from the occupational social worker, trying to reflect on this professional intervention. Therefore we discuss the relevance of the dissertation and the necessary work of professional social work in the space created by the Federal Government and operated by the Caixa Economica Federal, through the Technical Working Projects Social - PTTs. This program, which parallels the physical work of urban development programs, relies on the services of social workers who work on various activities such as: mobilization and community organization, educational process promoting themes of environmental education and health, and employment and income generation. We focus on the experiences of work done by social workers in cities located in the region of Piracicaba/SP
Mestre
Gifoni, Markus Andret Cavalcante. "Envolvimento da pentraxina 3 (PTX3) na patogênese da cistite hemorrágica induzida por ifosfamida em camundongos." reponame:Repositório Institucional da UFC, 2008. http://www.repositorio.ufc.br/handle/riufc/2592.
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The Hemorrhagic Cystitis (HC) is an inflammatory reaction usually associated with Cancer Chemotherapy with Oxazaphosphorines. It is an innate inflammatory response to vesical irritation by Acrolein, an hepatic metabolite of the treatment with Iphosphamide and Cyclophosphamide. The role of toll-like receptor (TLR) engagement and TNF-α and IL-1β expression and the involvement of iNOS and COX-2 in the pathogenesis has been well demonstrated in a murine model of HC. Recent data configure pentraxin 3 (PTX3) as an inflammatory mediator in several experimental models of innate immune response in vivo, with a straight relation with TLR engagement. Because of that, this study looks at the involvement of PTX3 in the pathogenesis of iphosphamide–induced HC in mice. For this purpose, the mRNA to PTX3 and IL-1β t was quantified by RT-PCR in groups of C57BL6 mice treated with Iphosphamide or Saline. After that, groups of transgenic and Knock-Out mice to PTX3 and its respectives wild-type controls were treated with Iphosphamide or saline with intention to measure the Bladder Wet Weight (BWW), histomorphometric scores and Immunohistochemistry and RT-PCR to PTX3, IL-1β, TNF-α e iNOS analysis. The transgenic mice and its controls were killed in 3h and 12h after the treatment, while the PTX3 KO and its controls were killed after 12 hours. Finally, the experimental HC was modulated by pretreatment with Talidomide, Pentoxiphiline, MESNA, Amifostine and Aminoguanidine and the bladders submitted to immunohistochemistry assay (PTX3, TNF-α, IL-1β and iNOS). By RT-PCR quantification, mRNA for PTX3 was expressed 70 times more in mice treated with iphosphamide than in controls, while IL-1β RNAm had an expression rate of 10 times. PTX3 transgenic mice had initial reduction of the inflammatory response with less expression of PTX3 and TNF-α and greater expression of iNOS. In the other hand, after 12 hours, the PTX3 transgenic mice had more inflammatory signs with superior expression of all the mediators. There was no difference between the PTX3 KO mice and its controls in the HC intensity although differences between groups were seen in cytokines expression. Talidomide and MESNA produced substantial reduction on the PTX3 expression, the same was seen to TNF-α, while the amifostine marked inhibition of HC had low effect on PTX3 expression. These data as a whole, point to an unequivocal involvement of PTX3 in the pathogenesis of innate inflammatory response of HC in mice with close relation with TNF-α engagement.
A cistite hemorrágica (CH) é um fenômeno inflamatório frequentemente associado à quimioterapia com oxazafosforinas. Trata-se de uma resposta inflamatória inata à ação da Acroleína (ACR), metabólito hepático comum à Ifosfamida (IFO) e à ciclofosfamida (CTX). O papel da resposta ao recrutamento de receptores toll-like (TLR) e do estímulo por TNF-α e IL-1β com envolvimentto de iNOS e COX-2 tem sido demonstrado neste fenômeno. Estudos recentes demonstram que a Pentraxina 3 (PTX3) assume papel de mediador inflamatório em modelos de resposta inflamatória inata in vivo, sobretudo relacionada ao recrutamento de TLR. Desta forma, o presente estudo pretende investigar o possível envolvimento de PTX3 na patogênese da CH induzida por ifosfamida em camundongos. Para isso, foi realizada quantificação de RNAm por RT-PCR para PTX3 e IL-1β em camundongos C57/ BL6 tratados com ifosfamida e salina. Em seguida, o modelo experimental da CH induzida por ifosfamida foi reproduzido em grupos de camundongos com hiperexpressão e nocauteados para PTX3 em comparação com os respectivos controles do tipo selvagem e com grupos controle tratados com salina para posterior obtenção dos pesos vesicais úmidos (PVU), realização de análise histomorfométrica, imunohistoquímica e quantificação de RNAm por RT-PCR para PTX3, IL-1β, TNF-α e iNOS. Os animais transgênicos e seus controles foram sacrificados com tempos de 3h e 12h após o tratamento, enquanto os nocauteados e seus controles foram sacrificados com 12 horas do tratamento. Finalmente, a CH em animais C57/ BL6 foi modulada com o pré-tratamento com Talidomida, Pentoxifilina, MESNA, Amifostina e Aminoguanidina para a posterior marcação imunohistoquímica com PTX3, IL-1β, TNF-α e iNOS. Observou-se que o RNAm de PTX3 está cerca de 70 vezes mais expresso em animais com CH, contra uma razão de expressão de 10 para IL-1β. Animais trangênicos para PTX3 têm redução inicial da resposta inflamatória com expressão inferior de PTX3 e TNF-α e expressão aumentada de iNOS e intensificação da inflamação ao tempo de 12 horas, com expressão superior dos mediadores. Não houve diferenças significativas de intensidade da CH em animais KO em relação aos controles. A modulação da CH por talidomida e MESNA produziu redução importante sobre a expressão de PTX3, enquanto a inibição da CH por amifostina não teve redução expressiva da pentraxina. Em conjunto, estes dados apontam para um envolvimento inequívoco de PTX3 na fisiopatologia da inflamação inata em modelo de CH murino com íntima relação coma expressão de TNF-α.
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