Dissertations / Theses on the topic 'PTX'
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Atkinson, Allen Bradley Jr. "A Model for the PTX Properties of H2O-NaCl." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/34376.
Full textA statistical model that relates the vapor pressure of H2O-NaCl to the fluid temperature and composition has been developed. The model consists of equations that predict the vapor pressure of H2O-NaCl from the eutectic temperature (-21.2°C) to 1500°C and for all compositions between the pure end-members. The model calculates the vapor pressure based on the composition (wt% NaCl) and the temperature of homogenization, which can be directly obtained from laboratory studies of fluid inclusions. This information in turn can be used to construct the isochore, or line of constant volume, along which the fluid inclusion was trapped. Finally the isochore can be used to determine the temperature and pressure at which the host mineral of the fluid inclusion was trapped.
Master of Science
Burgess, Vanessa Anne, and n/a. "Toxicology Investigations With The Pectenotoxin-2 Seco Acids." Griffith University. School of Public Health, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030905.090222.
Full textBurgess, Vanessa Anne. "Toxicology Investigations With The Pectenotoxin-2 Seco Acids." Thesis, Griffith University, 2003. http://hdl.handle.net/10072/365382.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Public Health
Faculty of Health Sciences
Full Text
Lee, Mei Ki. "Chemokine signaling via PTX-insensitive G proteins : activation of transcription factors and chemotaxis /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20LEE.
Full textSantos, Paulo Carlos Ferreira dos. "Extração de informações de desempenho em GPUs NVIDIA." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/45/45134/tde-02042013-090806/.
Full textThe recent growth in the use of tailored for performance Graphics Processing Units (GPUs) in scientific applications, generated the need to optimize GPU targeted programs. Performance models are the suitable tools for this task and they benefits from existing GPUs performance information extraction tools. This work covers the creation of a microbenchmark generator using PTX instructions and it also retrieves information about the GPU hardware characteristics. The microbenchmark results were validated using a simplified model with errors rates between 6.11% and 16.32% under five diferent GPU kernels. We also explain the imprecision factors present in the microbenchmark results. This tool was used to analyze the instructions performance profile, identifying groups with similar behavior. We also evaluated the corelation of the GPU pipeline performance and instructions execution sequence. Compiler optimization capabilities for this case were also verified. We concluded that the use of microbenchmarks with PTX instructions is a feasible approach and an efective way to build performance models and to generate detailed analysis of the instructions\' behavior.
Gumbrecht, Rene [Verfasser], and Paul [Akademischer Betreuer] Müller. "Development of customized pTx MR excitation methods and their safe application / Rene Gumbrecht. Gutachter: Paul Müller." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1075474167/34.
Full textLanctôt, Christian. "Rôle des gènes à boîte homéo de la famille Ptx au cours de l'embryogénèse de la souris." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0009/NQ39757.pdf.
Full textSchneider, Rainer [Verfasser], Jens [Akademischer Betreuer] Haueisen, Jürgen [Akademischer Betreuer] Reichenbach, and Josef [Akademischer Betreuer] Pfeuffer. "Selective Excitation MR Imaging with Parallel Transmission (pTx) / Rainer Schneider. Gutachter: Jürgen Reichenbach ; Josef Pfeuffer. Betreuer: Jens Haueisen." Ilmenau : Universitätsbibliothek Ilmenau, 2015. http://d-nb.info/1072072882/34.
Full textSchneider, Rainer Verfasser], Jens [Akademischer Betreuer] [Haueisen, Jürgen [Akademischer Betreuer] Reichenbach, and Josef [Akademischer Betreuer] Pfeuffer. "Selective Excitation MR Imaging with Parallel Transmission (pTx) / Rainer Schneider. Gutachter: Jürgen Reichenbach ; Josef Pfeuffer. Betreuer: Jens Haueisen." Ilmenau : Universitätsbibliothek Ilmenau, 2015. http://nbn-resolving.de/urn:nbn:de:gbv:ilm1-2015000033.
Full textVietta, Giovanna Grünewald. "Caracterização dos níveis da pentraxina-3 (PTX-3) em amostra de pacientes com cardiopatia isquêmica estável na população brasileira." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/17435.
Full textThiébaut, Stéphanie. "Influence de la duree de stockage sur les proprietes thermodynamiques, structurales et microstructurales des systemes pd 100-(x + y) ptx rhy - t2 (d2)." Paris 6, 1996. http://www.theses.fr/1996PA066709.
Full textFriedlander, Jonathan. "Deconstructing the Paxillin-GIT-PIX-PAX complex." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610099.
Full textHaselwarter, Kathrin. "Langzeit-Outcome nach chirurgischer Therapie von pT3- und pT4-Schilddrüsenkarzinomen." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1172/.
Full textDvořák, Petr. "Porovnání konvenčních PTP a PTN s proudovými a napěťovými senzory." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2019. http://www.nusl.cz/ntk/nusl-400564.
Full textTwieg, Michael D. "APPLICATIONS OF GALLIUM NITRIDE FETS TO RF ARRAYS FOR MAGNETIC RESONANCE IMAGING." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459253932.
Full textBuhl, Stephanie [Verfasser]. "Retrospektive Analyse zum operativen, onkologischen und funktionellen Ergebnis von Patienten mit Nierenzellkarzinom im Stadium pT1/pT2 / Stephanie Buhl." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1160515247/34.
Full textWETZEL, OLIVIER. "Prevention des recidives des tumeurs superficielles de vessie (pta, pt1, ptis) par instillations endovesicales de bcg : 55 patients." Nantes, 1992. http://www.theses.fr/1992NANT126M.
Full textArtico, Fausto. "Performance Optimization Of GPU ELF-Codes." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3424532.
Full textGPUs (Graphic Processing Units) sono di interesse per il loro favorevole rapporto $\frac{GF/s}{price}$. Rispetto all'inizio - primi anni 70 - oggigiorno le architectture GPU sono più simili ad architectture general purpose ma hanno un numero (molto) più grande di cores - la architecttura GF100 rilasciata da NVIDIA durante il 2009-2010, per esempio, ha una vera gerarchia di memoria cache, uno spazio unificato per l'indirizzamento in memoria, è in grado di eseguire calcoli in doppia precisione ed ha un massimo 512 core. Sfruttare la potenza computazionale delle GPU per applicazioni non grafiche - passate o presenti - è, comunque, sempre stato difficile. Inizialmente, nei primi anni 2000, la programmazione su GPU avveniva (esclusivamente) attraverso l'uso librerie grafiche, le quali rendevano la scrittura di codici non grafici non triviale e tediosa al meglio, e virtualmente impossibile al peggio. Nel 2003, furono introdotti il compilatore e il sistema runtime Brook che diedero agli utenti l'abilità di generare codice GPU da un linguaggio di programmazione ad alto livello. Nel 2006 NVIDIA introdusse CUDA (Compute Unified Device Architecture). CUDA, un modello di programmazione e computazione parallela specificamente sviluppato da NVIDIA per le sue GPUs, tenta di facilitare ulteriormente la programmazione general purpose di GPU. Codice scritto in CUDA è portabile tra differenti architectture GPU della NVIDIA e questa è una delle ragioni perché NVIDIA afferma che la produttività degli utenti è molto più alta di precedenti soluzioni, tuttavia ottimizare codice GPU con l'obbiettivo di ottenere le massime prestazioni rimane molto difficile, specialmente per NVIDIA GPUs che usano l'architecttura GF100 - per esempio, Fermi GPUs e delle Tesla GPUs - perché a) il vero instruction set architecture (ISA) è non pubblicamente disponibile, b) il codice del compilatore NVIDIA - nvcc - è non aperto e c) gli utenti non possono scrivere codice usando il vero assembly - ELF nel gergo della NVIDIA. I compilatori, mentre permettono un immenso incremento della produttività di un programmatore, eliminando la necessità di codificare al (tedioso) livello assembly, sono incapaci di ottenere, a questa data, prestazioni simili a quelle di un programmatore che è esperto in assembly ed ha una buona conoscenza dell'architettura sottostante. Infatti, è largamente accettato che programmazione ad alto livello e compilazione perfino con compilatori che sono considerati allo stato dell'arte perdono, in media, un fattore 3 in prestazione - e a volte molto di più - nei confronti di cosa un buon programmatore assembly potrebbe ottenere, e questo perfino su una macchina convenzionale, semplice, a singolo core. Compilatori per macchine più complesse, come le GPU NVIDIA, sono propensi a fare molto peggio perché tra le altre cose, essi devono determinare (persino più) complessi trade-offs durante la ricerca di soluzioni a problemi spesso indecidibili e NP-hard. Peraltro, perché NVIDIA a) rende virtualmente impossibile guadagnare accesso all'attuale linguaggio assembly usato dalla architettura GF100, b) non spiega pubblicamente molti dei meccanismi interni implementati nel suo compilatore - nvcc - e c) rende virtualmente impossible imparare i dettagli della molto complessa architecttura GF100 ad un sufficiente livello di dettaglio che permetta di sfruttarli, ottenere una stima delle differenze prestazionali tra programmazione in CUDA e programmazione a livello macchina per GPU NVIDIA che usano la architecttura GF100 - per non parlare dell'ottenimento a priori di garanzie di tempo di esecuzione più breve - è stato, prima di questo corrente lavoro, impossbile. Per ottimizare codice GPU, gli utenti devono usare CUDA or PTX (Parallel Thread Execution) - un instruction set architecture virtuale. I file CUDA or PTX sono dati in input a nvcc che produce come output fatbin file. I fatbin file sono prodotti considerando l'architecttura GPU selezionata dall'utente - questo è fatto settando un flag usato da nvcc. In un fatbin file, zero o più parti del fatbin file saranno eseguite dalla CPU - pensa a queste parti come le parti C/C++ - mentre le rimanenti parti del fatbin file - pensa a queste parti come le parti ELF - saranno eseguite dallo specifico modello GPU per il quale i file CUDA or PTX sono stati compilati. I fatbin file sono normalmente molto differenti dai corrispodenti file CUDA o PTX e questa assenza di controllo può completamente rovinare qualsiasi sforzo fatto a livello CUDA o PTX per otimizzare la parte o le parti ELF del fatbin file che sarà eseguita / saranno eseguite dalla GPU per la quale il fatbin file è stato compilato. Noi quindi scopriamo quale è il vero ISA usato dalla architettura GF100 e generiamo un insieme di linea guida per scrivere codice in modo tale da forzare nvcc a generare fatbin file con almeno il minimo numero di risorse successivamente necessario per modificare i fatbin file per ottenere le volute implementazioni algoritmiche in ELF - questo da controllo sul codice ELF che è eseguito da qualsiasi GPU che usa l'architettura GF100. Durante il processo di scoperata del vero ISA scopriamo anche le corrispondenze tra istruzioni PTX e istruzioni ELF - una singola istructione PTX può essere transformata in one o più istruzioni ELF - e le corrispondenze tra registri PTX e registri ELF. La nostra procedura è completamente ripetibile per ogni NVIDIA Kepler GPU - non occorre che riscrivamo il nostro codice. Essere in grado di ottenere le volute implementazioni algoritmiche in ELF non è abbastanza per ottimizzare il codice ELF di un fatbin file, ci occorre infatti anche scoprire, comprendere e quantificare dei comportamenti GPU che non sono divulgati e che potrebbero rallentare l'esecuzione di codice ELF. Questo è necessario per comprendere come eseguire il processo di ottimizzazione e mentre noi non possiamo riportare qui tutti i risultati che abbiamo ottenuto, noi possiamo comunque dire che spiegheremo al lettore a) come forzare una distribuzione uniforme dei GPU thread blocks agli streaming multiprocessors, b) come abbiamo scoperto e quantificato diversi fenomeni riguardanti il warp scheduling, c) come evitare fenomeni di warp scheduling load unblanacing, che è non possible controllare, negli streaming multiprocessors, d) come abbiamo determinato, per ogni istruzione ELF, la minima quantità di tempo che è necessario attendere prima che un warp scheduler possa schedulare ancora un warp - si, la quantità di tempo può essere differente per differenti istruzioni ELF - e) come abbiamo determinato il tempo che è necessario attendere prima di essere in grado di leggere ancora un dato in un registro precedentemente letto o scritto - questo pure può essere differente per differnti istruzioni ELF e differente se il dato è stato precedentemente letto o scritto - e f) come abbiamo scoperto la presenza di un tempo di overhead per la gestione dei warp che non cresce linearmente ad un incremento lineare del numero di warp residenti in uno streaming multiprocessor. Successivamente, noi spiegamo a) le procedure di trasformazione che è necessario applicare al codice ELF di un fatbin file per ottimizzare il codice ELF e così rendere il suo tempo di esecuzione il più corto possibile, b) perché occorre classificare i fatbin file generati dal fatbin file originale durante il processo di ottimizzazione e come noi facciamo questo usando diversi criteri che come risultato finale permettono a noi di determinare le posizioni, occupate da ogni fatbin file generato, in una tassonomia che noi abbiamo creato, c) come usando la posizione di un fatbin file nella tassonomia noi determiniamo se il fatbin file è qualificato per una analisi empirica - che noi spieghiamo - una analisi teorica o entrambe and d) come - supponendo il fatbin file sia qualificato per una analisi teorica - noi eseguiamo l'analisi teorica che abbiamo ideato e diamo a priori - senza alcuna precedente esecuzione del fatbin file - la garanzia - questo supponendo il fatbin file soddisfi tutti i requisiti dell'analisi teorica - che l'esecuzione del codice ELF del fatbin file, quando il fatbin file sarà eseguito sulla architettura GPU per cui è stato generato, sarà la più breve possibile.
Beije, Gustav. "Pix." Thesis, Mittuniversitetet, Institutionen för informationssystem och –teknologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-36478.
Full textRapporten handlar om skapelsen av ett nytt spelramverk namngivet Pix som jämförs mot den existerande spelmotorn Godot. Syftet är att skapa ett spelram- verk som fokuserar på att göra arbetssättet smidigt för programmeraren samtidigt som det ger mycket kreativ makt till programmeraren. Pix använder C# som programmeringsspråk vilket körs på .NET Core plattformen. Det är upp- byggt med en Entity Component System (ECS) design vilket betyder att det är en dataorienterad design med ett fokus på komposition. Det medför en klar separation mellan logik och data. ECS designen medför också att serialisering samt använda sig av flera trådar blir väldigt enkelt. Jämförelsen mot spelmotorn Godot visar tydliga skillnader i hur man använder spelmotorn/spelramverket samt tydliga skillnader i filosofin kring hur en användare blir bekant med spelmotorn/spelramverket. De tydliga skillnader är hur större delen av arbetstiden i Godot spenderas i Godots grafiska gränssnitt medans Pix kan kontrolleras endast från kod om man inte skapar en editor själv. Programmering i Godot görs med skriptspråket GDScript. Det är gjort för att skapa vanlig spel funktionalitet och inte utöka spelmotorn med ny funktionalitet. Det betyder att hela motorn måste kompileras om för att lägga till mer avancerad funktionalitet vilket kan vara tidskrävande. I Pix är är det samma sak att programmera spel funktionalitet och utöka ramverket med ny funktionalitet. Det medför att så fort som man kan programmera ett spel i Pix kan man också utöka ramverket med mer funktionalitet. Det resulterar i att Godot är enklare att lära sig men samtidigt ger mindre makt till den vanlige användaren medans Pix är tvärtom. Kollar man på hur man använder sig av Pix samt de teknologierna Pix är uppbyggt med så kan man se att det skiljer sig från redan existerande alternativ. Det leder till att Pix kan vara ett gott alternativ för komplexa spel som inte kräver den mest avancerade grafiken.
Jallad, Samer. "Biomedical markers of response to intravesical BCG treatment in high-grade non-muscle invasive (PTA and PT1) transitional cell carcinoma of the bladder." Thesis, University of Brighton, 2015. https://research.brighton.ac.uk/en/studentTheses/9dab009b-4eaa-4f3a-a14c-a941f3948ccb.
Full textRobison, Heidi Joan. "Phonation Threshold Pressure and Phonation Threshold Flow in Rabbits Treated With Inhaled Corticosteroids Versus Controls." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/8936.
Full textJones, Clare Alexa. "Molecular pharmacology of P2X{sub4} and P2X{sub6} receptors for ATP." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620195.
Full textRodrigues, José Antonio. "Demodulador Argos III compatível com sinais PTT-A2 e PTT-A3." Instituto Nacional de Pesquisas Espaciais (INPE), 2018. http://urlib.net/sid.inpe.br/mtc-m21c/2018/08.01.12.38.
Full textNowadays previous warning of impending natural and environmental disasters, accurate climate prediction, and detailed understanding of the status of global water resources are everyday issues that are extremely important to the global community. The National Meteorological and Hydrological Services throughout the world are responsible for providing this information, which is necessary for the protection of the environment, economic development (transportation, energy, agriculture, etc.) and the safety of life and property. In this context, one of the services widely used worldwide is the International Data Collection System which is composed of geostationary and low-orbit (nongeostationary) satellite networks. INPE develops and operates the Brazilian Data Collection System (BDCS), which is basically composed by the Data Collection Satellite (DCS) 1 and 2, the China-Brazilian Earth Resources Satellite (CBERS) 4, 1100+ Data Collection Platforms (DCPs) distributed in the Brazilian territory, two Receiving Ground Stations (RGS) at Cuiabá-MT, and Alcântara-MA, and one MISSION Center (MC) at the INPE Northeast Regional Center (INPE/NRC) at Natal, RN The BDCS has been operating since 1993 using an analog technology that has become obsolete and must be replaced by digital systems with on-board data decoding and storage. In this scenario, carrier frequency and phase synchronization and symbol time estimation have a fundamental importance for the correct reception of the signal arriving at the receiver. Therefore, it was proposed the development of a solution for these functions using digital signal processing using MatLab codes. For the implementation of frequency synchronization, the chosen solution uses xii a second-order Digital PLL, taking into account requirements such as the Doppler Effect. For the symbol time estimator we used the feedforward algorithm, which uses a simple implementation structure, a simplification of the one proposed in [16]. Also a simple solution of a linear interpolator was used to determine the delay time. The result presented by the frequency / phase synchronizer was satisfactory for operation in part of the range. The symbol time estimator also presented satisfactory results for Eb / N0 in the 0 to 11 dB range, with a loss of less than 0.5 dB over the theoretical value.
Van, Zyl Leonardo Joaquim. "Analysis of the mobilization region of the broad host-range IncQ-like plasmid, pTC-F14, and its ability to interact with a related plasmid, pTF-FC2." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/70109.
Full textENGLISH ABSTRACT: The 14.2 kb plasmid pTC-FI4 was isolated from the moderately thermophilic (45°- 50°C), highly acidophilic (pH 1.5 to 2.5), chemolithotrophic bacterium Acidithiobacil/us caldus and has a replicon that is closely related to the promiscuous, broad host-range, IncQ-family of plasmids. The region containing the mobilization genes was sequenced and encoded five Mob proteins and an origin of transfer, which are related to the DNA processing (Tral) region of IncPI plasmids, rather than to the three Mob protein systems of the IncQ-l-group plasmids (e.g. plasmids RSFIOIO or R1162). Plasmid pTC-F14 is the third example of an IncQ family plasmid that has five mob genes, with the others being pTF-FC2 and pRAS3.1. The minimal region that was essential for mobilization included the mobA, mobB and the mobC genes as well as the oriT. The mobD and mobE genes were non-essential, but together enhanced the mobilization frequency by approximately 300-fold. The repB gene increased the mobilization frequency but was not essential for mobilization. Mobilization of pTC-F14 between Escherichia coli strains by a chromosomally integrated RP4 plasmid was more than 3500-fold less efficient than the mobilization ofpTF-FC2. When both plasmids were co-resident in the same E. coli host, pTC-FI4 was mobilized at almost the same frequency as pTF-FC2. This enhanced pTC-FI4 mobilization frequency was due to the presence of a combination of the pTF-FC2 mobD and mobE gene products, the functions of which are still unknown. pTF-FC2 could mobilize the oriT of pTC-FI4 whereas pTC-F14 could only mobilize the pTFFC2 oriT if provided with some of the mobilization genes from the pTC-FC2 mobilization region. Unexpectedly either the mobEDC genes or the mobAB genes would allow the mobilization of the pTF-FC2 oriT by pTC-F14 even though there was no common gene between the two subsets. No evidence for any negative effect on the transfer of one plasmid by the related, potentially competitive plasmid was obtained.
AFRIKAANSE OPSOMMING: Die 14.2 kb plasmied, pTC-F14, is uit die matig termofiliese (45°C tot 50°C), hoogs asidofiliese (pH 1.5 tot 2.5), chemolitooutotrofiese bakterium Acidithiobaci/lus caldus geisoleer en beskik oor 'n replikon wat verwant is aan die vanaf die IncQ-familie van plasmiede. Hierdie plasmiede is alom bekend vir hulle promiskuïteit tydens konjugasie asook hul vermoë om in 'n groot aantal verskillende gasheer organismes te kan repliseer. DNA volgorde analise van die mobiliserings area het 'n oordrags oorsprong asook vyf oop leesrame onthul wat nader verwant is aan die DNA prosseserings gene van die Tral area op die IncP 1 plasmiede, as die van die mobiliserings stelsel van die IncQ-l-groep plasmiede. Plasmied pTC-Fl4 is die derde voorbeeld, saam met pTF-FC2 en pRAS3.1, van 'n IncQ-tipe plasmied met 'n vyfgeen mobiliserings sisteem. Die kleinste area op die plasmied nodig vir mobilisering van pTC-Fl4 is bepaal, en het die mobA, mobB en mobC gene sowel as die oordrags oorsprong ingesluit. Saam, was die mobD en mobE gene verantwoordelik vir 'n 300- voud toename in die mobilisasie frekwensie van pTC-Fl4 alhowel die gene nie absoluut nodig was vir mobilisering van die plasmied nie. Die repB geen het ook bygedra tot die frekwensie waarteen die volledige plasmied gemobiliseer was, maar hierdie geen was ook nie nodig vir mobilisering van die pTC-F14 plasmied nie. Die frekwensie waarteen pTC-Fl4 tussen Escherichia coli rasse beweeg het tydens konjugasie, terwyl gebruik gemaak is van 'n chromosomaal geintegreerde RP4 plasmied, was ongeveer 3500-voud laer as die van pTF-FC2. Indien beide pTC-Fl4 en pTF-FC2 in dieselfde E. coli gasheer aangetref word, word beide plasmiede teen ongeveer dieselfde frekwensie gemobiliseer. Die verhoogde frekensie vir pTC-Fl4 was as gevolg van die teenwoordigheid van beide die mobD en mobE gene van die pTF-FC2 plasmied, waarvan die funksies nog onbekend is. Plasmied pTF-FC2 kon die oordrags oorsprong van pTC-Fl4 mobiliseer waarteenoor plasmied pTC-FI4 die oordrags oorsprong vanafpTF-FC2 slegs kon mobiliseer indien een van twee dele van die pTF-FC2 mobiliserings gene voorsien word (al was daar geen oorvleuling tussen die twee nie). Alhoewel die plasmiede moontlik kon kompeteer op die vlak van plasmied oordrag is geen negatiewe kompetesie waargeneem tussen dié twee verwante plasmiede nie.
Tonon, Sandrine. "La toxine de Bordetella pertussis active les cellules dendritiques et les lymphocytes T CD4 naïfs chez l'homme." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210749.
Full textnourrissons non ou partiellement immunisés. Actuellement, la coqueluche provoque encore la
mort d’environ 350.000 individus par an. La toxicité de la PTX est liée à l’activité
enzymatique de sa sous-unité A capable d’inhiber les voies de signalisation associées aux
protéines Gi. La partie B, quant à elle, permet l’entrée de cette sous-unité A dans le
cytoplasme des cellules cibles en se liant spécifiquement à son ou ses récepteurs
membranaires toujours inconnus de nos jours.
Des études réalisées chez la souris et chez l’homme ont montré que les vaccins anticoquelucheux combinés à différents antigènes vaccinaux étaient capables de moduler
leurs réponses humorales spécifiques. Par ailleurs, la PTX est couramment qualifiée d’agent
immunostimulant. En effet, des modèles murins de vaccination permirent d’identifier des
propriétés adjuvantes de la PTX coadministrée avec des antigènes non relevants.
Le travail développé dans ce manuscrit étudie les effets de la PTX sur 2 types cellulaires
primordiaux sollicités lors d’une vaccination :la cellule dendritique (DC) et le lymphocyte T
CD4+ naïf.
Les DC sont les seules cellules présentatrices d’antigènes aptes à initier une réponse immune
primaire. Dans un premier temps, nous avons montré que la PTX était capable d’activer des
DC générées in vitro à partir de monocytes. En effet, elles acquièrent un phénotype mature
caractérisé par une augmentation de l’expression membranaire des molécules costimulatrices
et du CMH de classe II, démontrant un effet direct et spécifique de la PTX sur les DC
myéloïdes. Parallèlement, ces DC produisent du TNF-a, de l’IL-12p40 et de l’IL-12p70 et
activent NF-kappaB, un facteur de transcription essentiel au processus de maturation. Nous
avons obtenu des résultats similaires avec une toxine génétiquement modifiée qui est
enzymatiquement inactive. A partir de sang total incubé avec la PTX, nous avons par ailleurs
observé que les DC circulantes du nouveau-né étaient déficientes dans leur maturation et leur
sécrétion d’IL-12p70 comparées aux DC de l’adulte.
D’autre part, il a été décrit précédemment que la PTX exerçait des effets mitogènes sur les
lymphocytes T humains et murins. Cependant, le rôle qu’elle joue sur la population des
lymphocytes T CD4 naïfs reste peu connu. A l’issue de notre second travail, nous pouvons
dès lors affirmer que la PTX est également capable d’activer des lymphocytes T
CD4+CD45RA+ naïfs isolés à partir des cellules mononuclées du sang périphérique, et ce
indépendamment de son activité enzymatique. En effet, ces lymphocytes T CD4+ naïfs stimulés par la PTX prolifèrent, synthétisent des quantités non négligeables d'ARN messagers
codant pour l’IL-2 et le TNF-a, augmentent l’expression membranaire des molécules CD40L,
CD69 et CD25 et expriment la protéine Foxp3. Cette activation s’accompagne de la translocation nucléaire de NF-kappaB et NFAT. Parallèlement à l’adulte, la PTX active les lymphocytes T CD4 néonataux. Néanmoins, ceux-ci prolifèrent moins bien et expriment plus faiblement le CD40L à leur surface.
Enfin, la PTX induit la sécrétion de taux importants d’IFN-g par des T CD4+CD45RA+ naïfs
adultes mis en présence de DC autologues.
Nous terminerons en proposant l’hypothèse suivante :La PTX pourrait exercer ses propriétés
adjuvantes par l’intermédiaire de différents mécanismes comprenant notamment la maturation
des DC d’origine myéloïde et l’activation des lymphocytes T CD4+CD45RA+ naïfs. Ces 2 populations cellulaires sont en effet les principaux protagonistes impliqués dans la réponse
immune primaire.
Doctorat en sciences pharmaceutiques
info:eu-repo/semantics/nonPublished
Grenier, Denis. "De la Pax Romana à la Pax Senensis : Ambrogio Lorenzetti et l'Antiquité." Master's thesis, Université Laval, 1993. http://hdl.handle.net/20.500.11794/17657.
Full textFaust, Eberhard. "Pax Christi et Pax Caesaris : religionsgeschichtliche, traditionsgeschichtliche und sozialgeschichtliche Studien zum Epheserbrief /." Freiburg : Göttingen : Schweiz : Universitätsverlag ; Vandenhoeck & Ruprecht, 1993. http://catalogue.bnf.fr/ark:/12148/cb355768183.
Full textAlhabashneh, Mohammad Abad Alhameed. "Protect team handler (PTH)." Thesis, University West, Department of Technology, Mathematics and Computer Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-567.
Full textThere is always a need for easy-to-follow processes that enable accurate and non-time consuming solutions. Nowadays we see a lot of different approaches to development processes in software engineering. This project is concerned with how to manage a software development process in a reliable, secure and efficient way. Software is available which provides some help for project managers / administrators to work more productively, with effective communication. Using such systems, it is possible to keep track of all the phases of development, including task distribution, making maximum use of previous hands-on experience and increasing productivity, to deliver a finished product in minimum time. No existing solution, however, fulfills all the desirable criteria. This paper describes the motivation, design and implementation of an improved development management system using Active Server Pages and Microsoft Internet Information Services with a backend Microsoft Access Database developed using a waterfall software development process. The resulting system is described and evaluated. This system will be beneficial for software houses, because they can communicate on the web, allowing efficiency gains by avoiding the need to call meetings for distribution of tasks among employees, with the additional advantage of location-transparent team management through the Internet.
Borden, J. Benjamin. "New-fangled copper pox /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1328049371&sid=17&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Full textSimmler, Urs. "PTC Creo Simulate 3.0." Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-171761.
Full textBüttner, Rene. "PTC Mathcad Prime 3.1." Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-172536.
Full textWüst, Michael, and Steffen Förster. "PTC Mathcad Prime : Überblick." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-142117.
Full textAgarwal, Asit. "PTC Creo Simulate updates." Technische Universität Chemnitz, 2018. https://monarch.qucosa.de/id/qucosa%3A21379.
Full textVilímek, Hynek. "Převod PPTX do HTML." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2016. http://www.nusl.cz/ntk/nusl-255407.
Full textMaxwell, Megan Amanda, and n/a. "PEX1 Mutations in Australasian Patients with Disorders of Peroxisome Biogenesis." Griffith University. School of Biomolecular and Biomedical Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040219.100649.
Full textMaxwell, Megan Amanda. "PEX1 Mutations in Australasian Patients with Disorders of Peroxisome Biogenesis." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/366184.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
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Simmler, Urs. "Mechanism-News in PTC Creo." Universitätsbibliothek Chemnitz, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-141525.
Full textSibley, David N. "Viscoelastic flows of PTT fluid." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518114.
Full textOrmond, Susan Jane. "Trafficking of heteromeric P2X purinoreceptors." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614886.
Full textHibell, Amanda Dawn. "Functional characteristics of P2X₇ receptors." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621665.
Full textAlhabashneh, Mohammad Abad Alhameed. "Project and team handler (PTH)." Thesis, Högskolan Väst, Institutionen för teknik, matematik och datavetenskap, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-567.
Full textCoronado, Jose. "PTC Creo Simulate 4 Roadmap." Universitätsbibliothek Chemnitz, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-206764.
Full textRoberts, Arwel W. "BaTiO₃ ceramics for PTC applications." Thesis, Durham University, 1994. http://etheses.dur.ac.uk/1428/.
Full textChavan, Arun T. "PTC CREO SIMULATE ENGINE UPDATES." Universitätsbibliothek Chemnitz, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-225870.
Full textZheng, Wenxuan. "Properties of mammalian P2X₇ receptors." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/properties-of-mammalian-p2x7-receptors(1ff23f4a-47eb-4d06-b54c-bd7488c9700c).html.
Full textSilva, Villablanca Oscar. "Puerto terrestre de Casablanca : PTC." Tesis, Universidad de Chile, 2006. http://repositorio.uchile.cl/handle/2250/100956.
Full textVlk, Bronislav. "Možnosti videokonferencí v PBX Asterisk." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219738.
Full textSelldén, Magnus. "Estimering av laster på PTO-kraftuttag." Thesis, Linköpings universitet, Fordonssystem, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68660.
Full textTo extend the possible use of a truck it can be equipped with auxillary equipment for handling cargo and different working tools. These are powered using a Power Take-Off (PTO) connected to the vehicle´s drivetrain. In the current situation the control system lacks information about these loads, which can have a negative impact on the control. In this thesis a method for estimating the unknown PTO torque is presented. The method is based on Newtons second law of motion describing the motion of the flywheel. The driving torque from the drivetrain is described by a dynamic model. By calculating how much torque that should suffice in the present driving situation and comparing this to the torque delivered by the engine, the parasitic losses and unknown external loads can be estimated. A sensitivity analysis of the ambient influence on the model and the PTO estimation shows that the estimation cannot be performed in a robust and reliable way. The errors that arise from faulty input to the model such as deficient road slope and vehicle mass information result in errors with greater magnitude than the load torque to be estimated. It is also concluded that in the Engine Management System (EMS), the calculation of the torque delivered by the engine can show a static error of up to approximately 70Nm.
Straukaitė, Erika. "UAB "PTA Group" vartotojų lojalumo tyrimas." Bachelor's thesis, Lithuanian Academic Libraries Network (LABT), 2010. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2010~D_20100903_001321-49819.
Full textSUMMARY In this final work of Bachelor studies are submitted the concept and essence in customer loyalty structured by foreign and Lithuanian authors, analyzing the factors, witch form customer loyalty, benefits of the company of loyal customers, examined the types of loyalty and loyalty measurement methods. According to literature reviewed in the formation of loyalty and respect through loyalty expert F. Reicheldo, J. J. Elling, S. Jorgensen loyalty measurement approaches was taken UAB “PTA Group's” customer loyalty analyze. Component parts of final work of Bachelor studies are: 1. customer loyalty concepts, formation, value and measurement analysis of the theoretical aspect; 2. customer loyalty study analysis on UAB “PTA Group” in the city of Siauliai. The study included 100 women in the city of Siauliai, which know and have been visited at least once or bought in PTA clothing shop. After not only current and stable, but potentially loyal customers survey done, was found not only what factors most affect the attachment and a positive attitude to PTA but also was founded the reasons of disloyalty and what neutral and potentially loyal consumers groups lead to buy PTA. Considering to permitted level of loyal consumers, PTA can create marketing strategies to differentiate their offerings and incentives. These studies may be useful in improving PTA company's marketing strategy, expanding the catchment segment according to customer opinions and needs and of the majority of the... [to full text]
Rolf, Michael George. "P2X₁ receptors and human platelet function." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621241.
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