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Journal articles on the topic 'Psync'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Drăgoi, Cezara, Thomas A. Henzinger, and Damien Zufferey. "PSync: a partially synchronous language for fault-tolerant distributed algorithms." ACM SIGPLAN Notices 51, no. 1 (April 8, 2016): 400–415. http://dx.doi.org/10.1145/2914770.2837650.

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Davis, Kevin C., W. Douglas Evans, and Kian Kamyab. "Effectiveness of a National Media Campaign to Promote Parent–Child Communication About Sex." Health Education & Behavior 40, no. 1 (April 13, 2012): 97–106. http://dx.doi.org/10.1177/1090198112440009.

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Background. Although there is debate on the effectiveness of youth-focused abstinence education programs, research confirms that parents can influence their children’s decisions about sexual behavior. To leverage parent-based approaches to adolescent sexual health, the U.S. Department of Health and Human Services launched the Parents Speak Up National Campaign (PSUNC) to encourage parent–child communication about sex. Previous experimental studies have found the campaign to be efficacious in increasing parent–child communication. But to date, the actual reach of the campaign and its real-world effectiveness in promoting parent–child communication has not been established. The present study addresses this gap. Method. The authors surveyed 1,804 parents of 10- to14-year-old children from the nationally representative Knowledge Networks online panel. The survey included questions about parents’ awareness of PSUNC ads and parent–child communication behaviors. The authors also analyzed market-level data on campaign gross rating points, a measure of market-level intensity of PSUNC advertising in the United States. Multivariate regressions were used to examine the association between PSUNC exposure and a three-item scale for parent–child communication. Results. Overall, 59.4% of parents in the sample reported awareness of PSUNC. The authors found that higher market-level PSUNC gross rating points were associated with increased parent–child communication. Similar relationships were observed between self-reported awareness of PSUNC and increased frequency of communication and recommendations to wait. These associations were particularly strong among mothers. Conclusions. This study provides the first field-based data on the real-world reach and effectiveness of PSUNC among parents. The data support earlier experimental trials of PSUNC, showing that the campaign is associated with greater parent–child communication, primarily among mothers. Further research may be needed to develop additional messages for fathers.

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Hinterleitner, Martina, Bence Sipos, Verena Wagner, Julia M. Grottenthaler, Ulrich M. Lauer, Lars Zender, and Clemens Hinterleitner. "Platelet-Expressed Synaptophysin (pSyn) as Novel Biomarker in Neuroendocrine Malignancies." Cancers 13, no. 10 (May 11, 2021): 2286. http://dx.doi.org/10.3390/cancers13102286.

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Neuroendocrine neoplasms (NENs) encompass a heterogeneous group of tumors. Whereas low-grade neuroendocrine tumors (NETs) are histologically well-differentiated, highly aggressive neuroendocrine carcinomas (NECs) are characterized by a high proliferation rate and a worse clinical outcome. Since most NEN patients need monitoring of tumor progress and response to treatment for a long period of time, especially in metastatic disease, reliable, dynamic, and easy-to-assess biomarkers are needed. In this prospective study, we identified platelet-expressed synaptophysin (pSyn) as a novel biomarker in NENs. The level of pSyn in NENs was significantly upregulated compared to healthy donors. pSyn was positively correlated with higher tumor stages, the occurrence of metastasis, histological grading, and higher tumor proliferation (Ki67). Most importantly, high pSyn expression in our NEN cohort was shown to predict shorter progression-free survival (PFS). In conclusion, our data highlight the potential of pSyn as a novel biomarker in NENs reflecting tumor stages, grading, and prognosis.

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Lim, Lily Siok Hoon, Arlette Lefebvre, Susanne Benseler, and Earl D. Silverman. "Longterm Outcomes and Damage Accrual in Patients with Childhood Systemic Lupus Erythematosus with Psychosis and Severe Cognitive Dysfunction." Journal of Rheumatology 40, no. 4 (March 1, 2013): 513–19. http://dx.doi.org/10.3899/jrheum.121096.

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Objective.(1) To describe the clinical course and response to treatment; and (2) to evaluate and compare damage accrual of distinct phenotypic subgroups of patients with clinically important psychiatric illness of pediatric systemic lupus erythematosus (pSLE).Methods.A single-center cohort study of patients with pSLE followed at a pediatric lupus clinic from 1985 to July 2009. Clinical course and response to treatment were studied. Remission was defined by absence of psychiatric/cognitive symptoms while receiving minimal doses of prednisone. Disease activity and damage were measured using SLE Disease Activity Index and SLE Damage Index.Results.Fifty-three children were included: 40 with psychosis and cognitive dysfunction (PSYC group) and 13 with isolated cognitive dysfunction (COG group). All received immunosuppressive treatment. Eighteen of 32 treated with azathioprine required a change to cyclophosphamide for poor response but none on cyclophosphamide required a change. The median times to remission were 72 weeks (PSYC) and 70 weeks (COG). Eight patients (7 PSYC, 1 COG) experienced flare following response/remission. New damage was noted in 50% of children at a median of 11 months: 57% of PSYC group, 31% of COG group. Persistent cognitive dysfunction was seen in 16% of PSYC patients and 15% of COG patients.Conclusion.Most patients responded to immunosuppressive treatment, although median time to remission was > 1 year. Roughly half the patients acquired a new damage item, most of which did not interfere with functional abilities. Fewer than 20% of patients developed neuropsychiatric damage. Both phenotypes of psychiatric pSLE responded equally well to current treatment.

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Owusu-Ansah, Ebenezer, and Colin Dalton. "Fabrication of a 3D Multi-Depth Reservoir Micromodel in Borosilicate Glass Using Femtosecond Laser Material Processing." Micromachines 11, no. 12 (December 6, 2020): 1082. http://dx.doi.org/10.3390/mi11121082.

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Micromodels are ideal candidates for microfluidic transport investigations, and they have been used for many applications, including oil recovery and carbon dioxide storage. Conventional fabrication methods (e.g., photolithography and chemical etching) are beset with many issues, such as multiple wet processing steps and isotropic etching profiles, making them unsuitable to fabricate complex, multi-depth features. Here, we report a simpler approach, femtosecond laser material processing (FLMP), to fabricate a 3D reservoir micromodel featuring 4 different depths—35, 70, 140, and 280 µm, over a large surface area (20 mm × 15 mm) in a borosilicate glass substrate. The dependence of etch depth on major processing parameters of FLMP, i.e., average laser fluence (LFav), and computer numerically controlled (CNC) processing speed (PSCNC), was studied. A linear etch depth dependence on LFav was determined while a three-phase exponential decay dependence was obtained for PSCNC. The accuracy of the method was investigated by using the etch depth dependence on PSCNC relation as a model to predict input parameters required to machine the micromodel. This study shows the capability and robustness of FLMP to machine 3D multi-depth features that will be essential for the development, control, and fabrication of complex microfluidic geometries.

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6

Tantum, Digby. "A guide to the internet for psychotherapists." Psychiatric Bulletin 25, no. 1 (January 2001): 29–30. http://dx.doi.org/10.1192/pb.25.1.29.

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One of the best collections of links to USA psychotherapy sites is at Mental Health Directory (http://www.mental-health.net). In the UK, two good starting points are: the Centre for Psychotherapeutic Studies at the University of Sheffield (http://www.shef.ac.uk/-psysc/) and Chris Evans' website (http://www.psyctc.org/).

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Chan, Betty, Jeffrey R. Cottrell, Bing Li, Kelley C. Larson, Crystle J. Ashford, Jonathan M. Levenson, Pascal Laeng, David J. Gerber, and Jianping Song. "Development of a High-Throughput AlphaScreen Assay for Modulators of Synapsin I Phosphorylation in Primary Neurons." Journal of Biomolecular Screening 19, no. 2 (October 2, 2013): 205–14. http://dx.doi.org/10.1177/1087057113505905.

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Alterations in synaptic transmission have been implicated in a number of psychiatric and neurological disorders. The discovery of small-molecule modulators of proteins that regulate neurotransmission represents a novel therapeutic strategy for these diseases. However, high-throughput screening (HTS) approaches in primary neurons have been limited by challenges in preparing and applying primary neuronal cultures under conditions required for generating sufficiently robust and sensitive HTS assays. Synapsin I is an abundant presynaptic protein that plays a critical role in neurotransmission through tethering synaptic vesicles to the actin cytoskeleton. It has several phosphorylation sites that regulate its modulation of synaptic vesicle trafficking and, therefore, the efficacy of synaptic transmission. Here, we describe the development of a rapid, sensitive, and homogeneous assay to detect phospho-synapsin I (pSYN1) in primary cortical neurons in 384-well plates using AlphaScreen technology. From results of a pilot screening campaign, we show that the assay can identify compounds that modulate synapsin I phosphorylation via multiple signaling pathways. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders.

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Wang, Ji Lin. "Wavelet Digital Watermarking Algorithm on the Basis of SVD Decomposition." Applied Mechanics and Materials 333-335 (July 2013): 1056–59. http://dx.doi.org/10.4028/www.scientific.net/amm.333-335.1056.

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Based on SVD decomposition, an digital watermarking algorithm with the method of wavelet transform is proposed. By means of singular value decomposition to realize blind extracting, the watermarking image is embedded into intermediate frequency sub bands of wavelet composition. Finally, applying normalized cross-correlation function (NC) and peak signal to noise ratio (PSNC), it has proved that this algorithm has better invisibility and robustness.

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Nahrin, Noor E., Fatema Ashraf, Khairun Nessa, Md Alfazzaman, Shaheen Ara Anwary, Syed AM Asfarul Abedin, and MM Mafizur Rahman. "The Emotional-Psyc hological Consequences of Infertility and Its Treatment." Medicine Today 29, no. 1 (August 31, 2017): 42–44. http://dx.doi.org/10.3329/medtoday.v29i1.33861.

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Infertility is a major public health concern accounting for 10%-15% all over the world. In Bangladesh about 24.51 million patients receive infertility advice or treatment. The emotional consequences of an infertility diagnosis can be devastating. One study in Taiwan diagnosed anxiety in 23% and major depression in 17% of the women seeking assisted reproductive infertility treatment. The aim of this case presentation is to addressing the psychological consequences of infertility and its treatment. The findings of this case study are: 1. Understanding the reactions of infertility (mental engagement; psychological turmoil). 2. Consequences of therapy process (reduced self-esteem; feelings of failure, economic burden). 3. Emotional-affective reactions to therapy process (fear, anxiety and worry; fatigue and helplessness; grief and depression; hopelessness). This case study revealed that infertile women seeking treatment face several psychological-emotional problems with devastating effects on the mental health and well-being of the infertile individuals and couples, while the infertility is often treated as a biomedical issue with less attention on the mental-emotional, social and cultural aspects.Medicine Today 2017 Vol.29(1): 42-44

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Verdolini, Norma, Silvia Amoretti, Gisela Mezquida, Bibiana Cabrera, Manuel J. Cuesta, Mara Parellada, Ana Gonzalez-Pinto, Iluminada Corripio, Eduard Vieta, and Miguel Bernardo. "S229. THE EFFECT OF FAMILY ENVIRONMENT ON LONGITUDINAL FUNCTIONING IN FIRST PSYCHOTIC EPISODES." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S125—S126. http://dx.doi.org/10.1093/schbul/sbaa031.295.

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Abstract Background Family environment plays a key role in the development of psychotic symptoms (Pitschel-Walz et al., 2001; Tienari et al., 2004) and negative family environmental factors are linked to poor prognosis in psychosis (Geller et al., 2000). By contrast, a positive family environment is associated with greater improvements in negative and disorganized symptoms among individuals at imminent risk of becoming psychotic (O’Brien et al., 2006). Nonetheless, little is known about the implication of family environment on longitudinal functioning in patients that presented a first psychotic episode. Methods This study is part of the “Phenotype-genotype and environmental interaction. Application of a predictive model in ﬁrst psychotic episodes” (PEPS) study, a multicentric, longitudinal, naturalistic follow-up study (Bernardo et al., 2013). The Functional Assessment Short Test (FAST) was used to assess functional outcome. The Family Environment Scale (FES) evaluated family emotional climate in different categories: COHESION (C) for mutual reliance; EXPRESSIVITY (EX), the extent to which family members express their feelings directly; CONFLICTS (CON) for open expression of anger, aggressiveness and conflict; INDEPENDENCE (IND), the extent to which family members are independent in their decisions; ACHIEVEMENT ORIENTATION (AO) for an achievement-orientated environment; INTELLECTUAL–CULTURAL ORIENTATION (ICO) for political, intellectual, cultural interests; ACTIVE–RECREATIONAL ORIENTATION (ARO) for participation in social activities; MORAL–RELIGIOUS EMPHASIS (MRE) for the importance given to ethical and religious practices and values; ORGANIZATION (ORG) for the organization in activities and responsibilities; and CONTROL (CTL), the extent to which the family considers rules and established procedures. Patients with a first psychotic episode (FEPs) and healthy controls (HCs) have been evaluated baseline and after two years of follow-up. Diagnoses at 2 years have been established according to the Structured Clinical Interview for DSM-IV. Linear regression models have been conducted in order to assess the effect that different family environments exert on functioning at baseline but also at 2 years of follow-up, when the group of FEPs has been divided in patients diagnosed with psychotic disorders (PSYC) versus bipolar disorder (BD). All data were analyzed with the Statistic Package for Social Sciences (SPSS v.23 for Windows). All the analyses were two-tailed with alpha set at p < 0.05. Results At baseline, the total sample included 335 FEPs (mean FAST=27.8±16.1) and 253 HCs (mean FAST 3.5±8.1). At baseline the linear model was not significant neither for FEPs nor for HCs and no family environment was associated with functioning. At 2 years (mean FAST BD=13.8±15.1, mean FAST PSYC =20.98±15.4), in the BD group (F(10,14)=2.6, p=.05) worse functioning was associated with CON (β=.741, p=.004) whilst in the PSYC group (F(10,108)=3.509, p=<.001) it was negatively associated with ARO (β=- .305, p=.006) and AO (β=- .204, p=.039) and positively associated with MRE (β=.268, p=.003). Discussion At baseline, no specific family environment was associated with functioning. At 2 years, in BD worse functioning was associated with higher rates of open expression of conflict in the family whilst in PSYC it was associated with lower rates of participation in social activities and achievement-orientated family environment as well as with higher rates of religious practices and values. Family environment exerts an important role in the functioning of FEPs mainly in the long-term, with important implications for early interventions for both patients and caregivers.

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Ruiz-Serrano, Álvaro, Nicholas D. M. Hine, and Chris-Kriton Skylaris. "Pulay forces from localized orbitals optimized in situ using a psinc basis set." Journal of Chemical Physics 136, no. 23 (June 21, 2012): 234101. http://dx.doi.org/10.1063/1.4728026.

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12

Boutros, Sydney Weber, Jacob Raber, and Vivek K. Unni. "Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex." Journal of Parkinson's Disease 11, no. 3 (August 2, 2021): 1091–115. http://dx.doi.org/10.3233/jpd-212566.

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Background: Alpha-synuclein (αsyn) characterizes neurodegenerative diseases known as synucleinopathies. The phosphorylated form (psyn) is the primary component of protein aggregates known as Lewy bodies (LBs), which are the hallmark of diseases such as Parkinson’s disease (PD). Synucleinopathies might spread in a prion-like fashion, leading to a progressive emergence of symptoms over time. αsyn pre-formed fibrils (PFFs) induce LB-like pathology in wild-type (WT) mice, but questions remain about their progressive spread and their associated effects on behavioral performance. Objective: To characterize the behavioral, cognitive, and pathological long-term effects of LB-like pathology induced after bilateral motor cortex PFF injection in WT mice and to assess the ability of mouse αsyn-targeted antisense oligonucleotides (ASOs) to ameliorate those effects. Methods: We induced LB-like pathology in the motor cortex and connected brain regions of male WT mice using PFFs. Three months post-PFF injection (mpi), we assessed behavioral and cognitive performance. We then delivered a targeted ASO via the ventricle and assessed behavioral and cognitive performance 5 weeks later, followed by pathological analysis. Results: At 3 and 6 mpi, PFF-injected mice showed mild, progressive behavioral deficits. The ASO reduced total αsyn and psyn protein levels, and LB-like pathology, but was also associated with some deleterious off-target effects not involving lowering of αsyn, such as a decline in body weight and impairments in motor function. Conclusions: These results increase understanding of the progressive nature of the PFF model and support the therapeutic potential of ASOs, though more investigation into effects of ASO-mediated reduction in αsyn on brain function is needed.

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Gupta, A., S. Chandrasekhar, R. Pal, S. Ahlawat, and O. Singh. "High expression of human chorionic gonadotrophin beta-subunit using a synthetic vaccinia virus promoter." Journal of Molecular Endocrinology 26, no. 3 (June 1, 2001): 281–87. http://dx.doi.org/10.1677/jme.0.0260281.

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We have constructed a recombinant vaccinia virus to express the beta-subunit of human chorionic gonadotrophin (betahCG), a secretory glycoprotein that is used as an antigen for a contraceptive vaccine. The cDNA encoding the subunit was cloned under the control of a synthetic promoter that could be recognised by a vaccinia virus RNA polymerase to direct transcription. The peak expression level of betahCG directed by a late synthetic promoter (Psyn) was 11.5 microg/ml, a level that was at least sixfold higher than that directed by the p7.5 early/late promoter. The expressed protein was correctly processed post-translationally such that it attained a conformation with correctly folded discontinuous epitope(s) similar to that seen in native betahCG.

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Mandal, Lata, A. Seethalakshmi, and Anitha Rajendra Babu. "Protocol for a Systematic Review of Rationing of Nursing Care." Journal of Health and Allied Sciences NU 08, no. 02 (June 2018): 015–18. http://dx.doi.org/10.1055/s-0040-1708748.

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Abstract Purpose: To identify and synthesize the findings of studies related to “rationing of nursing care”. Methods: Preferred Reporting Items for Systematic Reviews and Meta analysis (PRISMA) guidelines will be followed in this review and literature searches will be conducted in MEDLINE, CINAHL, Psyc Info, Web of Science and EMBASE databases. Only quantitative studies meeting the predetermined inclusion criteria, quality standards and credibility will be synthesised using narrative synthesis. Results: A descriptive synthesis of the findings of the selected studies will be carried out which will be presented in narrative summary with statistical findings incorporated. Conclusion: This review will provide a synthesis of up to date evidence regarding the rationing of care by nurses. It will also support the hypothesis that rationing of care has effects on patients and nurses and explore relationship of rationing of care with patients and nursing outcome.

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Friedman, Daniela B., and Laurie Hoffman-Goetz. "A Systematic Review of Readability and Comprehension Instruments Used for Print and Web-Based Cancer Information." Health Education & Behavior 33, no. 3 (June 2006): 352–73. http://dx.doi.org/10.1177/1090198105277329.

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Adequate functional literacy skills positively influence individuals' ability to take control of their health. Print and Web-basedcancer informationis oftenwritten at difficult readinglevels. This systematic review evaluates readability instruments (FRE, F-K, Fog, SMOG, Fry) used to assess print and Web-based cancer information and word recognition and comprehension tests (Cloze, REALM, TOFHLA, WRAT) that measure people's health literacy. Articles on readability and comprehension instruments explicitly used for cancer information were assembled by searching MEDLINE and Psyc INFO from 1993 to 2003. In all, 23 studies were included; 16 on readability, 6 on comprehension, and 1 on readability and comprehension. Of the readability investigations, 14 focused on print materials, and 2 assessed Internet information. Comprehension and word recognition measures were not applied to Web-based information. None of the formulas were designed to determine the effects ofvisuals ordesignfactorsthat couldinfluencereadabilityandcomprehensionofcancereducationinformation.

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Sen, Secil. "Paula Rowe, Heavy Metal Youth Identities: Researching the Musical Empowerment of Youth Transitions and Psyc." Volume !, no. 15 : 2 (June 17, 2019): 109–12. http://dx.doi.org/10.4000/volume.6739.

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Horan, John J., and Chris D. Erickson. "Fellowship Behavior in Division 17 and the MOMM Cartel." Counseling Psychologist 19, no. 2 (April 1991): 253–59. http://dx.doi.org/10.1177/0011000091192011.

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Graduates and employees of four institutions-the MOMM Cartel-dominate every science and practice organ of Division 17's governing body. Counseling psychologists from the other 60 academic programs (the OUTSIDERs) face numerous barriers to professional ascendancy. Six of 13 fellow nominees during the 1988-1989 year were MOMM members; none were rejected. Three OUTSIDERs were elected; four were rejected. Mean scholarly productivity for each group was 13, 21.3, and 19.7 Psyc LIT citations, respectively. The accepted OUTSIDERs were significantly more productive than the MOMMs; two of the four rejected OUTSIDERs ranked numbers one and two in scholarly productivity among all nominees. No relationship appeared between scholarship and fellow decisions; MOMM membership strongly predicted election to fellow status. Personal familiarity with the evaluators, rather than professional service, apparently accounts for these filings -a variant of the "Matthew Effect" discussed in the sociology-of-science literature Recommendations for reform are offered

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Azevêdo, Adriano Valério dos Santos, Antônio Carlos Lançoni Júnior, and Maria Aparecida Crepaldi. "Interação equipe de enfermagem, família, e criança hospitalizada: revisão integrativa." Ciência & Saúde Coletiva 22, no. 11 (November 2017): 3653–66. http://dx.doi.org/10.1590/1413-812320172211.26362015.

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Resumo Este estudo tem o objetivo de apresentar uma revisão integrativa de artigos científicos, referentes à produção nacional e internacional, sobre interação equipe de enfermagem, família, e criança hospitalizada. Foram realizadas consultas nas bases de dados Bireme, Lilacs, Medline, IBECS, Psyc Info, Science Direct, e Web of Science (2008-2013), o que permitiu identificar 31 artigos, os quais são representados pelos seguintes eixos temáticos: Relação interpessoal, Comunicação e Cuidado. O estabelecimento de relações interpessoais, de maneira técnica e formal, ocasiona dificuldades na comunicação e nas ações destinadas ao cuidado. O cuidado foi o tema predominante nestas pesquisas, acompanhantes reivindicam dos profissionais de saúde uma atenção ampliada às necessidades da criança e da família, e maior envolvimento de todos no processo de cuidado. Os resultados sugerem a necessidade da equipe de saúde reconhecer a dinâmica vivenciada pela díade (criança/acompanhante), para que possibilite desenvolver a atenção integral que favoreça a inclusão da família e da criança por meio de estratégias de humanização.

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Leavy, Annette. "Editor's Note." Psychoanalysis and Psychotherapy 24, no. 1 (April 1, 2007): 2. http://dx.doi.org/10.3200/psyc.24.1.2.

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Leavy, Annette. "Dialogues on Terror: Patients and Their Psychoanalysts, Part III." Psychoanalysis and Psychotherapy 24, no. 1 (April 1, 2007): 60. http://dx.doi.org/10.3200/psyc.24.1.60.

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Raichvarg, Daniel, and Claude Wacjman. "Présentation." Psychologie clinique, no. 27 (2009): 5–6. http://dx.doi.org/10.1051/psyc/2009271005.

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Lê, Anne-Laurence. "La psychiatrie domestique : auto-thérapie ou péril thérapeutique ?" Psychologie clinique, no. 27 (2009): 7–16. http://dx.doi.org/10.1051/psyc/2009271007.

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Babou, Igor. "Le cerveau du sujet comme objet médiatique, confrontations de légitimités et inscription dans des représentations." Psychologie clinique, no. 27 (2009): 17–32. http://dx.doi.org/10.1051/psyc/2009271017.

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Sendra, Sophie. "Épistémologie d’unbest-seller: Aldous Huxley,Les portes de la perception." Psychologie clinique, no. 27 (2009): 33–47. http://dx.doi.org/10.1051/psyc/2009271033.

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Paquet, Dominique. "La Double vie de Félida." Psychologie clinique, no. 27 (2009): 48–62. http://dx.doi.org/10.1051/psyc/2009271048.

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Smadja, Isabelle. "Folie du moi et/ou folie du monde dans le théâtre contemporain." Psychologie clinique, no. 27 (2009): 63–75. http://dx.doi.org/10.1051/psyc/2009271063.

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Valmer, Michel. "Le Fou et le Savant, culbuto théâtral d’une société en équilibre instable." Psychologie clinique, no. 27 (2009): 76–91. http://dx.doi.org/10.1051/psyc/2009271076.

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Pommier, Gérard. "Quelle valeur scientifique faut-il accorder aux exposés cliniques ?" Psychologie clinique, no. 27 (2009): 92–104. http://dx.doi.org/10.1051/psyc/2009271092.

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Beach, Thomas G., Charles H. Adler, Lucia I. Sue, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Anthony J. Intorcia, et al. "Vagus Nerve and Stomach Synucleinopathy in Parkinson’s Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the “Body-First” Hypothesis." Journal of Parkinson's Disease, June 14, 2021, 1–11. http://dx.doi.org/10.3233/jpd-212733.

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Background: Braak and others have proposed that Lewy-type α-synucleinopathy in Parkinson’s disease (PD) may arise from an exogenous pathogen that passes across the gastric mucosa and then is retrogradely transported up the vagus nerve to the medulla. Objective: We tested this hypothesis by immunohistochemically staining, with a method specific for p-serine 129 α-synuclein (pSyn), stomach and vagus nerve tissue from an autopsy series of 111 normal elderly subjects, 33 with incidental Lewy body disease (ILBD) and 53 with PD. Methods: Vagus nerve samples were taken adjacent to the carotid artery in the neck. Stomach samples were taken from the gastric body, midway along the greater curvature. Formalin-fixed paraffin-embedded sections were immunohistochemically stained for pSyn, shown to be highly specific and sensitive for α-synuclein pathology. Results: Median disease duration for the PD group was 13 years. In the vagus nerve none of the 111 normal subjects had pSyn in the vagus, while 12/26 ILBD (46%) and 32/36 PD (89%) subjects were pSyn-positive. In the stomach none of the 102 normal subjects had pSyn while 5/30 (17%) ILBD and 42/52 (81%) of PD subjects were pSyn-positive. Conclusion: As there was no pSyn in the vagus nerve or stomach of subjects without brain pSyn, these results support initiation of pSyn in the brain. The presence of pSyn in the vagus nerve and stomach of a subset of ILBD cases indicates that synucleinopathy within the peripheral nervous system may occur, within a subset of individuals, at preclinical stages of Lewy body disease.

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"Resources: PSNC posters." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11116314.

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"PSNC warning over false invoices." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11117178.

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"Fraud prevention boss to head PSNC." Pharmaceutical Journal, 2017. http://dx.doi.org/10.1211/pj.2017.20204130.

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Jordan, Bawks, and Sammy Boggs. "Blended Learning & the Redesign of Psyc 100." Inquiry@Queen's Undergraduate Research Conference Proceedings, February 5, 2016. http://dx.doi.org/10.24908/iqurcp.9018.

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A great deal of research has shown that lectures with large class sizes struggle to promote active learning resulting in poor knowledge acquisition and retention as well as limited conceptual understanding. Based on the benefits observed for blending learning models and small group learning in the literature, Introductory Psychology (Psyc 100) at Queen’s has recently undergone a massive redesign with the goal of improving the student experience.The structure of Psyc 100 has been changed from 3 hours of traditional lecture a week to 1 hour of lecture, 1 hour of online learning, and 1 hour of learning lab per week. The goal of this redesign is to increase student engagement through learning labs, grant more freedom to pursue the course material via interactive online tasks, and delve deeper into exciting and relevant topics with more in-depth lectures.The labs are specially designed with a student-centered approach that helps learners to engage with fellow students and the material through group discussions, quizzes, games, and debates. Upper year students majoring in Psychology comprise approximately 2/3 of the tutorial facilitators for these labs, which provide undergraduate students with an important opportunity to take a more active role in the Psychology department and develop a love for teaching.We will present the research behind this redesign, demonstrate how it has been incorporated into the new Psyc 100 curriculum, and share our experiences as student facilitators through the ongoing refinement of the course.

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"PSNC reassures on seasonal flu vaccine stocks." Pharmaceutical Journal, 2018. http://dx.doi.org/10.1211/pj.2018.20204244.

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"PSNC announces new funding package from April." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11118878.

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"Beware audits of confidential information, warns PSNC." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11120797.

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"Exploit funding reallocation, says PSNC vision document." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11124298.

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"Pharmacists "underperforming" on service delivery, says PSNC." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11129872.

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"PSNC seeks feedback on minor ailments commissioning toolkit." Pharmaceutical Journal, 2017. http://dx.doi.org/10.1211/pj.2017.20203170.

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"Community pharmacy must 'fight for survival', says PSNC." Pharmaceutical Journal, 2017. http://dx.doi.org/10.1211/pj.2017.20203712.

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"PSNC unveils business model for NHS service bids." Pharmaceutical Journal, 2014. http://dx.doi.org/10.1211/pj.2014.20065746.

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"Contractors will not police prescribers, PSNC tells DoH." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11116070.

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"PSNC creates business case for pharmacy flu jabs." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11123047.

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"PSNC and BAPW want reassurances over price negotiations." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11125083.

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"Category M cuts of £40m announced by PSNC." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11125791.

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"PSNC chief questions evidence for centralised dispensing proposals." Pharmaceutical Journal, 2015. http://dx.doi.org/10.1211/pj.2015.20200035.

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"PSNC releases ‘spectacular’ data on pharmacy flu vaccinations." Pharmaceutical Journal, 2016. http://dx.doi.org/10.1211/pj.2016.20201769.

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"PSNC in 'urgent talks' with government over medicine shortages." Pharmaceutical Journal, 2017. http://dx.doi.org/10.1211/pj.2017.20203639.

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"PSNC publishes guide to the General Data Protection Regulation." Pharmaceutical Journal, 2018. http://dx.doi.org/10.1211/pj.2018.20204601.

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"PSNC vision for community pharmacy could be more ambitious." Pharmaceutical Journal, 2013. http://dx.doi.org/10.1211/pj.2013.11124354.

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