Dissertations / Theses on the topic 'Psychotropic drugs'
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Antona, Annamaria. "Repurposing of psychotropic drugs for cancer therapy." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127826.
Full textChan, Kin-yi Ivy. "A study of determinants of relapse in psychotropic substance abuse /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19470757.
Full textMitchell, Alexander Lawson. "Regulation of 5-HT receptors by psychotropic drugs." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298235.
Full textGoldwasser, Ruth Pilczyk. "The usage of psychotropic medications by family caregivers /." Connect to thesis, 1996. http://eprints.unimelb.edu.au/archive/00002534.
Full textMoorman, Jennifer Mary. "Studies on neuroadaptation to psychotropic drugs involving serotonergic receptor function." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244529.
Full textPurcell, Gregory Mark. "Intervention to improve the level of documentation of antipsychotic related adverse drug reactions." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/10340.
Full textGolby, Jim. "Psychopharmacological aspects of skilled behaviour." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329505.
Full textChan, Kin-yi Ivy, and 陳健儀. "A study of determinants of relapse in psychotropic substance abuse." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31250038.
Full textBeckett, Nicola Michelle. "Isotopic Profiling of Selected Designer Drugs for Forensic Intelligence Purposes." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/366425.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Science, Environment, Engineering and Technology
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Confer, Jennifer, and Deborah Laird. "Psychotropic Polypharmacy in Outpatients with Schizophrenia: Comparison of Oral Psychotropic Adherence Rates, Duplication of Therapy, Psychiatric Hospitalizations, Cost of Services, and Concomitant Medications." The University of Arizona, 2007. http://hdl.handle.net/10150/624327.
Full textObjectives: A prescription claims database from COPE Behavioral Services in Tucson, Arizona was used to retrospectively assess the differences between patients receiving <4 and those receiving > 4 psychotropic medications over a 12-month period in adult patients with schizophrenia. Methods: Medication groups (i.e., < 4 versus > 4 concomitant psychotropic agents) were compared for differences in gender, age, duplication of antipsychotic therapy, adherence rates, court order treatment status, psychiatric hospitalization rates and length of stay, cost of services provided, and concomitant psychotropic medications. Results: A total of 506 adult patients with schizophrenia (F=214 and M=292) met the inclusion criteria for receiving psychotropic medications during the 12-month study. Of those, 388 patients (76.7%) were found to have an average of < 4 medications, while 118 patients (23.3%) were found to have > 4 medications. Duplication of antipsychotic therapy was more common in the > 4 group (29.7%) compared to the < 4 group (3.1%), p < 0.001. Psychotropic adherence rates were significantly higher in the > 4 group based on month’s supply of prescriptions. Demographic differences between groups included: increased age, more women, fewer court order status, and higher cost of care in the > 4 compared to the < 4 medication group. No differences in hospitalizations, length of stay, and hospital costs were found between groups. Conclusions: Our findings suggest that patients with schizophrenia with increased rates of polypharmacy have higher adherence rates, more duplication of antipsychotics, and a higher cost of care (i.e., case management, laboratory, other services, total prescription costs) compared to patients receiving < 4 psychotropic medications.
Dunbar, Philip Gordon. "Approaches to the synthesis of pentacyclic dibenzazepines and phenothiazines." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184295.
Full textVanderpot, Lynne Esther. "The interrelationship between spirituality and psychiatric medication use : a hermeneutic phenomenological study." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229440.
Full textMathis, Leigh Ann. "Student Psychotropic Drug Use, Past Therapy Experience and Length of Therapy." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/49.
Full textBell, Paul. "The use of saccadic eye movements in the clinical psychopharmacology of psychotropic drugs." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261766.
Full textWarne, Rhonda J. "Trends in the use of psychotropic medication in residential aged care facilities prior to and after the advent of an accredited pharmacist conducted medication review service." Thesis, The University of Sydney, 2001. https://hdl.handle.net/2123/27725.
Full textGartside, Sarah Elizabeth. "The effect of psychotropic drugs on 5-HT-mediated neuroendocrine responses in the rat." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302846.
Full textBackus, Lisa Ione. "Functional interactions between 5-HT receptor subtypes : implications for the actions of psychotropic drugs." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236178.
Full textWong, Deysi Viviana Tenazoa. "AvaliaÃÃo da equivalÃncia farmacÃutica da Carbamazepina e Diazepam comercializados no Programa de FarmÃcia popular do Brasil." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4186.
Full textA equivalÃncia farmacÃutica entre dois medicamentos relaciona-se à comprovaÃÃo de que ambos contÃm o mesmo fÃrmaco (mesma base, sal ou Ãster da mesma molÃcula terapeuticamente ativa), na mesma dosagem e forma farmacÃutica, o que pode ser avaliado por meio de testes in vitro. No Brasil, os medicamentos alopÃticos sÃo divididos em trÃs categorias quanto ao registro junto à AgÃncia Nacional de VigilÃncia SanitÃria: medicamentos novos, medicamentos similares e medicamentos genÃricos. O objetivo foi avaliar a EquivalÃncia FarmacÃutica da Carbamazepina 200 mg (CBZ) e Diazepam 10 mg (DZP) comercializados no programa FarmÃcia Popular do Brasil, visando discutir a importÃncia da qualidade dos medicamentos para a saÃde pÃblica. Utilizou-se como SubstÃncia QuÃmica de ReferÃncia (SQR) carbamazepina e diazepam, com teor declarado de 99,6 e 99,9%, respectivamente. Realizaram-se testes fÃsico-quÃmicos tais como: determinaÃÃo de peso mÃdio, desintegraÃÃo, dureza, friabilidade, teor, uniformidade de conteÃdo e perfil de dissoluÃÃo, segundo a FarmacopÃia Brasileira (F.Bras.) 4a ediÃÃo. Os resultados indicaram uma dureza menor nos comprimidos de DZP da FarmÃcia Popular. Em relaÃÃo ao Perfil de dissoluÃÃo da CBZ, a anÃlise por ANOVA indicou haver diferenÃas significativas (p<0,05) entre os perfis de dissoluÃÃo da FarmÃcia popular em relaÃÃo ao genÃrico e referÃncia nos tempos avaliados. Comparou-se o perfil de dissoluÃÃo do comprimido da FarmÃcia Popular em relaÃÃo ao medicamento referÃncia, atravÃs dos cÃlculos dos fatores de diferenÃa (f1) e semelhanÃa (f2). Obteve-se um valor de 46,29 e 35,00, respectivamente, indicando diferenÃas nos perfis avaliados. Nos comprimidos de DZP, verificou-se que os valores de percentagem de fÃrmaco dissolvido para as trÃs amostras avaliadas, foram superiores a 85% em 15 minutos de teste, e a comparaÃÃo pelo cÃlculo dos fatores de f1 e f2, nÃo pÃde ser aplicada neste caso. Evidenciou diferenÃa (p<0,05) nos primeiros 75 minutos avaliados para as trÃs amostras, o que pode nÃo ter uma significÃncia farmacÃutica. Os outros parÃmetros fÃsico-quÃmicos cumpriram com as especificaÃÃes da F. Bras. em todas as amostras de CBZ e DZP. Portanto, os comprimidos de CBZ da FarmÃcia Popular nÃo sÃo equivalentes farmacÃuticos em relaÃÃo ao medicamento referÃncia.
Two drugs are considered pharmaceutically equivalent when both contain the same drug (base, salt or ester of the same active ingredient), at the same dosage and pharmaceutical form determined in vitro. In Brazil, the allopathic drugs are classified into three cathegories when registered in the Brazilian health surveillance agency (AgÃncia Nacional de VigilÃncia SanitÃria): new, similar or generic drugs. This work aimed to determine the pharmaceutical equivalence of Carbamazepine 200 mg (CBZ) and Diazepam 10 mg (DZP) marketed in the Brazil Popular Pharmacy program, discussing the importance of drugs for public health. Carbamazepine SQR and Diazepam SQR were used as reference drugs with 99.6 and 99.9% declared content, respectively. Physicochemical studies, such as mean weight, disintegration, hardness, friability, content, content uniformity and dissolution profile were performed in accordance to Brazilian Pharmacopeia 4th edition. The results indicated a lower hardness of DZP Popular Pharmacy tablets. Despite the dissolution profile of CBZ, the ANOVA test presented significant statistical difference (p<0.05) between Popular Pharmacy tablets and generic or reference drugs in all the time point evaluated. The dissolution profile of Popular Pharmacy and reference tablets were compared through the f1 (difference) and f2 (similarity) factors. Values of 46.29 and 35.00 respectively were found suggesting a difference on the profiles evaluated. The DZP tablets, despite the sample, showed a dissolution fraction higher than 85% in 15 minutes. f1 and f2 were not possible to be calculated in these cases. The variance analysis evidenced, for all the samples, statistical difference (p< 0.05) in the first 75 minutes evaluated, what might not have pharmaceutical importance. The other physicochemical parameters were in accordance with Brazilian Pharmacopeia for all the CBZ and DZP samples. Therefore, the CBZ tables cannot be considered pharmaceutically equivalents to the reference ones.
Tamm, Leanne. "Single and combined effects of stimulant medication and contingencies on the cognitive performance of children with attention deficit hyperactivity disorder /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004383.
Full textLefever, Timothy W. "Effects of olanzapine on olfactory delayed matching-to-sample in rats." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-3/lefevert/timothylefever.pdf.
Full textNanchy, Nicole, and Michelle Sereese Green. "An exploratory study of barriers to psychotropic adherence from the client's perspective." CSUSB ScholarWorks, 2006. https://scholarworks.lib.csusb.edu/etd-project/3057.
Full textRitter, Erin C. "Portrayals of mental illness in primetime television and psychotropic drug commercials." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 0.26 Mb., 106 p, 2006. http://proquest.umi.com/pqdlink?did=1163268081&Fmt=7&clientId=79356&RQT=309&VName=PQD.
Full textMacPherson, Tom. "Genetic and pharmacological investigation of α4-containing GABAA receptors in conditioned behaviours influenced by cocaine." Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/47585/.
Full textFröhlich, Samanta Maria Etges. "Impacto do consumo de psicotrópicos nas despesas familiares no Brasil." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/142853.
Full textIntroduction: over the past four decades the use of psychotropic drugs increased its relevancy to the lives of millions of people. The direct and indirect costs associated to psychotropics are usually unknown. Economic aspects of psychotropic medicine have been studied in other countries, although such information is still scarce in Brazil. A data source for studies about household expenditure and health care costs is the Survey on Household Budgets. Objectives: to draw a profile of Brazilian people that acquire psychotropic drugs, as well as evaluate spends with these medicine and its impacts on the Brazilian household budget on the recent years. Methods: a cross-sectional study, with data used are from the Survey on Household Budgets from 2002-2003 and from 2008-2009, which involved interviews of a complex sample made of 48,470 households on 2003, 128,300 people and 55.970 homes in 2009. Poisson multilevel regression models with robust variance were made by SAS/SUDAAN 10.0.1. All income and spends were adjusted to a monthly basis and indexed by inflation. Results: the prevalence of psychotropics acquisition in the Brazilian population in 2008-2009 was of 5.2% (CI95%=5.0-5.5), resulting in an annual expenditure of R$507 millions. The use of psychotropic drugs was more frequent among women, white people, older people, do not co-habit with a spouse or partner, more schooled and wealthier. Individuals that spent with psycotropics had more 11 spends with health insurance (PR=1.40, CI95%: 1.30-1.50) and medical consults (PR=2.51, CI95%: 2.32-2.72). The average monthly spends with psychotropics per household increased from R$54.38 in 2003 to R$78.73 in 2009, with values indexed by inflation. Among the households that did not purchase psychotropics, the average monthly per capita income was of R$1,026.73 and the monthly per capita spends were, in average, of R$73.92 with health care, R$103.17 with food and R$12.77 with leisure. Among the household that presented expenditure with psychotropics, the average monthly per capita income was of R$1,154.40 and its average monthly per capita spends were of R$210.38 with health care, R$162.087 with food and R$15.45 with leisure. Conclusion: there was an above inflation increase in the psychotropic drugs spends between the evaluated years. The psychotropics acquisition relates to higher socio-economic leveled families. The differences that were found may represent different levels of access to medical diagnose and treatment and to medication. The Brazilian household budgets do not seem to re-adequate resources to meet the purchase of psychotropics. If the epidemiologic change, at its first stage, represented the transition from infectious diseases to non-transmissive chronic illnesses. the picture that can represent the future would be the neurodegenerative diseases, if the trend of increasing life expectancy is kept.
Giron, Maria Stella T. "The rational use of drugs in a population of very old persons /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-155-1.
Full textLesén, Eva. "Psychotropic drugs among the elderly : Population-based studies on indicators of inappropriate utilisationin relation to socioeconomic determinants and mental disordersEva LesénGothenburg." Doctoral thesis, Nordic School of Public Health NHV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:norden:org:diva-3721.
Full textBakgrund: Användning av läkemedel bland äldre är komplicerat på grund avmultisjuklighet, användning av flera läkemedel och en ökad känslighet för läkemedel.En av de vanligaste läkemedelsgrupperna hos äldre är psykofarmaka, som inkluderarantipsykotika, ångestdämpande, sömnmedel och antidepressiva läkemedel. Olämpliganvändning av läkemedel bland äldre är ett betydande folkhälsoproblem. Syfte: Det övergripande syftet med avhandlingen är att beskriva och analyserapotentiellt olämplig användning av psykofarmaka bland äldre i Sverige. De specifikasyftena är att undersöka i vilken utsträckning indikatorn ”samtidig användning av treeller fler psykofarmaka” fångar användningen av potentiellt olämpliga psykofarmaka(PIP) bland äldre och att analysera potentiellt olämplig användning av psykofarmaka irelation till förändring över tid, psykiatriska diagnoser, boendeform och socioekonomiska determinanter bland äldre i Sverige. Metod: Avhandlingen baseras på data från individbaserade register över läkemedelsköp och socioekonomiska determinanter under 2006, Göteborg 95+ studien (1996-1998)samt aggregerade data över läkemedelsförsäljning under 2000-2008. Överensstämmelsen mellan de två indikatorerna ”samtidig användning av tre eller flerpsykofarmaka” och PIP undersöktes. Användning av psykofarmaka och PIP studerades i relation till psykiatriska diagnoser och boendeform hos 95-åringar och i relation till socioekonomiska determinanter hos de som var 75 år och äldre. Vidare analyseradesförändring över tid i användning av PIP och rekommenderade psykofarmaka. Resultat: Hälften av alla äldre som var 75 år och äldre använde psykofarmaka under2006 och en femtedel av alla äldre använde PIP. En fjärdedel av individerna somanvände PIP fångades av indikatorn ”samtidig användning av tre eller flerpsykofarmaka”. Bland 95-åringarna med depression år 1996-1998 använde färre än enav tio antidepressiva läkemedel, medan sömnmedel och ångestdämpande läkemedel varvanligare. PIP var vanligare hos de äldre med låg inkomst och bland de som inte vargifta, jämfört med individer med hög inkomst och de gifta. Under 2000-2008 minskade användningen av PIP medan användningen av rekommenderade psykofarmaka ökade. Slutsatser: Det finns fortfarande stora problem i äldres användning av psykofarmaka.Avhandlingen visar en låg överensstämmelse mellan två indikatorer för olämpliganvändning av psykofarmaka, vilket pekar på betydelsen av att välja relevantaindikatorer. Avhandlingen visar också på socioekonomiska ojämlikheter i användningenav psykofarmaka hos äldre, en låg användning av antidepressiva läkemedel bland 95-åringar med depression och en ökning i användningen av rekommenderade istället förolämpliga psykofarmaka bland äldre
Lloyd, Edward John, and mikewood@deakin edu au. "A common structural basis for central nervous system drug design." Deakin University. School of Biological Sciences, 1986. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050902.115505.
Full textWieliczko, Monika J. "Psychological effects of MDMA." Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/14928/.
Full textShearer, James Douglas National Drug & Alcohol Research Centre Faculty of Medicine UNSW. "Modafinil for psychostimulant dependence." Publisher:University of New South Wales. National Drug & Alcohol Research Centre, 2008. http://handle.unsw.edu.au/1959.4/41423.
Full textStein, Dan J. "Philosophy of psychopharmacology : a naturalist approach." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/21761.
Full textENGLISH ABSTRACT: The use of psychiatric medication is an important part of modern medical and psychiatric practice. Clinical psychopharmacology raises a broad range of philosophical issues, including metaphysical, epistemological, and moral questions. This dissertation attempts to provide a conceptual framework for addressing several of these questions, and for formulating a conceptual basis for psychiatry in general and clinical psychopharmacology in particular. The dissertation begins by heuristically contrasting two broad approaches towards a range of questions in the philosophy of science, language, and medicine. A classical position takes an essentialist and objective view of categories while a critical position emphasizes that categories are often metaphoric and subjective. A synthetic or integrated position might be possible, in which radial categories are often based on metaphoric extensions of basic-level sensorimotor-affective experience, and are embodied in the brain-mind and in social practices. Rather than attempt to defend an integrated position in purely conceptual terms, the dissertation supports this view of categories using data from the cognitive-affective sciences. An important category for philosophy of medicine is disorder, and the dissertation argues that certain universal considerations explain agreement about prototypical disorders. Extensions of disorder metaphors are theory-driven and valueladen, and although disagreement about atypical conditions is likely, reasonable debate is possible. The dissertation then considers several conceptual questions, namely the nature of psychotropics, of emotion, and of the self. In each case, a classical position which attempts an essentialist definition is contrasted with a critical position which emphasizes that these constructs are socially constructed and crucially subjective. Cognitiveaffective data is then employed to support an integrative position which emphasizes the embodiment of complex brain-mind phenomena in the brain-mind and in social practices. Explanatory questions considered are how best to explain pharmacotherapy and psychotherapy, how to account for placebo responses, and the relevance of evolutionary explanations of disorder. It is argued that a functionalist account fails to explain psychopharmacological phenomena, including pharmacotherapy and placebo effects. Instead, an account which emphasizes how psychobiological mechanisms produce complex brain-mind phenomena is needed. Evolutionary explanations add to this account, but cannot by themselves differentiate disorder from non-disorder. Ethical questions include the question of whether psychiatric disorders should be treated, whether such disorders should be treated with psychotropics, and whether psychotropics should be used to enhance. The cognitive-affective sciences support the treatment of typical disorders. In more atypical cases, pharmacotherapy, psychotherapy, and non-medical interventions should be considered on an individual basis. As technologies expand, considerations about the value of accepting fate versus the value of attempting to improve life by a range of methods, will need to be weighed carefully. In summary, this dissertation puts forward a philosophy of psychopharmacology which argues that psychiatry practice can be viewed, naturalistically, as based on the natural and human sciences. At the same time, good psychiatric practice involves an engagement with the complex realities of the human condition, including a consideration of individuals’ suffering. Good psychopharmacological practice requires integrating the objective and the subjective, considering both explanation and understanding, and providing a balanced view of the good and bad of psychotropics that avoids both unrealistic optimism and undue pessimism.
AFRIKAANSE OPSOMMING: Die gebruik van psigiatriese medikasie maak belangrike deel uit van moderne mediese en psigiatriese praktyk. Psigofarmakologie bring wye reeks filosofiese kwessies ter sprake, met inbegrip van metafisiese, epistemologiese, en morele vrae. Hierdie proefskrif poog om konseptuele raamwerk te verskaf ten einde verskeie van hierdie vrae die hoof te bied, en na die formulering van konseptuele basis vir psigiatrie in die algemeen en kliniese psigofarmakologie in die besonder om te sien. Die proefskrif begin deur twee algemene benaderings ten opsigte van reeks vrae in die filosofie van wetenskap, taal en geneeskunde te kontrasteer. Klassieke posisie huldig essensialistiese en objektiewe siening van kategorieë, terwyl kritiese posisie klem daarop lê dat kategorieë dikwels metafories en subjektief is. Sintetiese of geïntegreerde posisie is dalk moontlik, met radiale kategorieë wat dikwels op metaforiese uitbreidings van konsepte op basiese vlak sensorimotor-affektiewe ervaring gebaseer word, en in die bewussyn-brein en in sosiale gebruike vergestalt word. Eerder as om te probeer om geïntegreerde posisie in suiwer konseptuele terme te verdedig, steun die proefskrif hierdie siening van kategorieë met behulp van data uit die kognitiewe-affektiewe wetenskappe. Belangrike kategorie vir die filosofie van geneeskunde is steuring, en die proefskrif voer aan dat sekere universele oorwegings ’n verklaring bied vir ooreenstemming ten opsigte van prototipiese steurings. Uitbreidings van die steuring metafoor is teoriegedrewe en waardebelaai, en alhoewel daar waarskynlik meningsverskil omtrent atipiese toestande kan voorkom, is redelike bespreking haalbaar. Die proefskrif neem dan verskeie konseptuele vrae in aanmerking, naamlik die aard van psigotropika, van emosie, en van die self. In elke geval word klassieke posisie wat essensialistiese definisie aandurf, gekontrasteer met kritiese posisie wat beklemtoon dat hierdie konstrukte sosiaal gekonstrueer en besonder subjektief is. Kognitiewe-affektiewe data word dan aangewend om integratiewe posisie te handhaaf wat die vergestalting van komplekse bewussyn-brein fenomene in die bewyssyn-brein en in sosiale praktyke beklemtoon. Verklarende vrae het aandag geskenk aan die beste wyse om farmakoterapie en psigoterapie te verklaar, aan die wyse waarop placebo-reaksies verklaar kan word, en aan die rol van proksimale en evolusionêre verklarings. Daar word aangevoer dat funksionalistiese verklaring nie daarin slaag om psigofarmakologiese verskynsels, met inbegrip van farmakoterapie en placebo-effekte, te verklaar nie. In plaas daarvan word verklaring wat beklemtoon hoe psigobiologiese meganisme komplekse fenomene kan laat ontstaan, benodig. Evolusionêre verklarings dra tot hierdie verklaring by, maar kan nie op sigself steuring van niesteuring onderskei nie. Etiese vrae sluit die vraag in of psigiatriese steurings behandel moet word, of sodanige steurings met psigotropika behandel moet word, en of psigotropika gebruik moet word om te verhoog. Die kognitief-affektiewe wetenskappe ondersteun die behandeling van tipiese steuringe. In meer atipiese gevalle moet farmakoterapie, psigoterapie, en nie-mediese intervensies op individuele basis oorweeg word. Algaande tegnologieë uitbrei, moet ons oorwegings van die waarde van lotsaanvaarding sowel as die waarde van ’n poging om ’n mens se lewe te verbeter, versigtig in ag neem. Ter opsomming, hierdie proefskrif stel filosofie van psigofarmakologie voor wat aanvoer dat psigiatriese praktyk naturalisties verstaan kan word, soos gebaseer op die natuur- en geesteswetenskappe. Terselfdetyd, behels goeie psigofarmakologiese praktyk ‘n verwantskap met die komplekse werklikhede van die menslike kondisie. Dit vereis ‘n omvattende oorweeging van en omgang met individuele pasiënte se lyding. Goeie psigofarmakologiese praktyk integreer die “objektiewe” en die “subjektiewe” aspekte van die menslike bestaan, streef na sowel verklaring en verstaan, verskaf ‘n gebalanseerde perspektief oor die goed en die sleg van psigiatriese medikasies, en middel tussen onrealistiese optimisme en buitensporige pessimisme.
Morello, Manuela Roque Siani. "Medicamentos psicoativos na rede pública de saúde de RibeirãoPreto-SP: perfil de utilização e fatores associados." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-30102014-163819/.
Full textThe increasing consumption of psychoactive drugs (PAD) in Brazil and worldwide, linked to the fact that some of these substances can cause physical and/or psychic dependence in their users, indicate the need to develop epidemiological studies providing support for planning of health interventions so as to ensure the rational use of these medicines. This cross-sectional study aims to estimate the prevalence and characterize the usage profile of PAD among drug users served by all health facilities\' pharmacies in Ribeirão Preto-SP, relating these findings with factors associated with the consumption of these substances. From september to december 2012, a sample of 1355 drug users (psychoactive or not) was interviewed while waiting in the pharmacies to get their medication. The researchers collected sociodemographic and health related data of individuals, in addition to registering all drugs contained in prescriptions. Then, three instruments were applied to assess the clinical variables (i) knowledge of pharmacotherapy, (ii) adherence to the pharmacotherapy and (iii) health related quality of life (QoL). The prevalence of PAD usage was 31,0% (n = 420), and the most prescribed were antidepressants (53,5%) and benzodiazepines (24,6%). Most PAD users were female (81,9%), lived with a partner (52,6%), did not have a job (70,7%), had a private health insurance (69,2%) and income per capita up to the minimum wage (54,0%), did not undergo follow-up with a psychologist (93,3%), did not practice regular physical activity (78,3%), consumed coffee daily (81,0%), did not consume alcohol (86,7%), did not smoke (81,4%) and were not found in polypharmacy (62,4%). The mean age was 54,5 (SD 13,9) and the average schooling corresponded to incomplete primary education. Over half of the users of MPA exhibited satisfactory knowledge about pharmacotherapy and were considered adherent (57,8% and 53,0%, respectively), and most showed no satisfactory QoL (73,1%). There was a statistically significant difference (p <0.05) between PAD users and nonusers for the variables gender, age, marital status, housing, employment status, caregiver, follow up with psychologist, regular physical activity, alcohol consumption, smoking, polypharmacy, average knowledge about pharmacotherapy, mean adherence to pharmacotherapy, satisfactory QoL, mean EQ-5D index and average self-reported QoL. The adjusted odds ratios (OR) showed that the factors positively associated with the PAD use were female gender (OR = 2,02; 95% CI 1,31; 3,11) and age (ORref./elderly = 0,36, 95% CI 0,13; 0,99). Considering benzodiazepines users, 51,1% reported being in use these PAD for at least two years, 55,1% of whom were elderly. Approximately one in three individuals used at least one PAD in the period studied, while the elderly and women were more likely to use. The most prevalent PAD were antidepressants and benzodiazepines, with most users of the latter receiving these MPA for over two years, of which more than half were elderly.
Öhman, Daniel. "Bioanalytical development for application in therapeutic drug monitoring : focus on drugs used in psychiatry /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med775s.pdf.
Full textGustafsson, Maria. "Optimizing drug therapy among people with dementia : the role of clinical pharmacists." Doctoral thesis, Umeå universitet, Geriatrik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118309.
Full textPooviboonsuk, Prakob. "An investigation of the relationship between event-related potentials (ERPs) and the amnesiac and sedative effects of psychotropic drugs." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339129.
Full textConte, Cécile. "Evaluation des consommations médicamenteuses associées au décours d'un lymphome : approche pharmacoépidémiologique." Thesis, Toulouse 3, 2018. http://www.theses.fr/2018TOU30185/document.
Full textThis thesis presents a pharmacoepidemiology approach to describe drug utilization in lymphomas during their whole care pathway. The use of the French claims database (Système National d'Informations Inter-Régimes de l'Assurance Maladie (SNIIRAM)) allows to exhaustively quantify this drug utilization in real life conditions. This thesis consists of three mains objectives. First, we aimed to develop validated algorithms for the identification of incident cases of lymphoma. For the validation, we used data from a regional Cancer Registry as the gold standard. The purpose of this validation study was to enhance validity of future studies conducted on lymphomas in the SNIIRAM database. The results of this study associated to strengths of this database demonstrate that this approach is of great interest to conduct pharmacoepidemiological or medico-economic studies in lymphomas. Second, we aimed to estimate the incidence of use of psychotropic drugs during the active treatment phase of lymphoma in comparison with control groups. Indeed, the increased probability of developing anxio-depressive disorders after diagnosis could lead to an increased initiation of psychotropic drugs and a potential inappropriate chronic use of these drugs after initiation. Such inappropriate chronic use can unnecessarily expose patients to adverse event. For this aim, we conducted a new-user cohort study using data from the SNIIRAM database. The results of this study revealed that the initiation rate of these drugs is higher than in the general population or for life-threatening diseases such as myocardial infarction. Moreover, we observed an inappropriate prolonged use for a significant fraction of patients (20% to more than 50% according to therapeutic class). On the basis of these findings, the third objective was to identify factors associated with prolonged use of these drugs during survivorship. This study was conducted using data from the General Sample of Beneficiaries (EGB). [...]
Hughes, Shannon. "Navigating Health Sources on the Internet: A Mixed-Methods Examination of Online Consumer Reviews and Expert Text on Psychotropic Drugs." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/231.
Full textMawanda, Francis. "Emerging risk factors for dementia: associations between clinical infections, PTSD, psychotropic PTSD medication use, and the risk for dementia." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2117.
Full textFontanella, Andréia Turmina. "Uso de psicofármacos : uma abordagem de gênero : dados da pesquisa nacional sobre o acesso, utilização e promoção do uso racional de medicamentos – PNAUM 2014." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/179737.
Full textAlthough widely prescribed, psychotropic drugs are still controversial as to their use. Large-scale use refers to other dimensions of the problem, which go beyond psychiatry and permeate areas of psychology and social sciences. Understanding the use of these drugs is, therefore, understanding the characteristics of the population that uses them. Thus, this dissertation aimed to describe the selfrefered prevalence of psychotropic medication use by the Brazilian urban population, focusing on the differences between men and women. For this, the overall prevalence and stratified by sex prevalence of the psychotropic drugs use were evaluated using data from the National Survey on Access, Use and Promotion of Rational Use of Medicines (Pnaum). The psychotropic drugs were grouped into four therapeutic classes: antidepressants; anxiolytics; antipsychotics and mood stabilizers. Prevalence, prevalence estimates and their 95% confidence intervals [95% CI] were calculated and Pearson's qui-square tests were used to assess the statistical significance of the differences between the groups, considering a significance level of 5%. Among those interviewed, 8.0% reported using at least one psychotropic drug. This prevalence rises to 10.9% when considered only female, which has a prevalence of use 2 times higher than men in the age group of 35 to 46 years of age. The prevalences of psychoactive drugs use for men, women and non-gender sample increases with increasing age, number of chronic diseases and number of drugs used to treat diseases. Antidepressants and anxiolytics appear as the most commonly used therapeutic classes, the same classes being more prevalent among women in all age groups, while antipsychotics and mood stabilizers were more prevalent among males. The results indicate a greater use of these drugs by women, and a differentiated 10 pattern between them and the men regarding the therapeutic classes. Seeking to understand these differences, this dissertation covers aspects related to the biological specificities of the sexes and to the social roles played by men and women, including its implications in the health model.
Machado, Pedro Nuno Fontão. "Perto de ti, matas. Longe de ti, eu morro: Uma etnografia sobre usos de drogas de rua." Master's thesis, Universidade de Évora, 2008. http://hdl.handle.net/10174/18503.
Full textLindqvist, Emma, and Maria Pixell. "Återhämtning efter psykos : En litteraturstudie." Thesis, Högskolan i Gävle, Avdelningen för hälso- och vårdvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-29027.
Full textBackground: Every year 1500-2000 people gets a psychosis in Sweden, and about 30000-40000 people in Sweden is diagnosed with schizophrenia. Medicines are the basis for the treatment of schizophrenia, this in combination with various psychosocial treatments as well as measures. Recovery is described as a deep personal, uniquechange process. Nurses in Sweden work according to the law “HSL”, the Swedish Health and Medical Service Act. Health is one of the nursing concepts that the nurse should work from outside.Aim: The aim of this study is to describe people diagnosed with schizophrenia experiences of recovery after psychosis, as well as describing the selection groups in thearticles. Methods: A descriptive literature study of 11 studies with a qualitative approach. Main results: In the present study, the purpose was to describe psychosocial experiencei n schizophrenia patients. What was found in the results showed that a strong support from the environment and medication was necessary for a good recovery. To spend time with family and friends gave a sense of acceptance and reduced the symptoms. Psychiatric drugs prove to affect sleep and quality of life in a negative way, which impeded compliance. Many described that they lost their self-esteem after psychosis, resulting in a worse self-esteem, inhibited recovery and return to work. When theyfound acceptance in their illness and did not see themselves as a diagnosis and learned to reach their goals, it promoted the recovery process and they could see a brighter future.Conclusion: People with schizophrenia experience difficulties in returning to normal life after a psychosis. The people tell that they lost their identity, friends, family and work and as a consequence they lost hope and prospects. This stigmatization depends largely on ignorance in society and therefore it is important as a nurse to have knowledge of this subject in order to provide good care.
Ayivor, Divine. "Policy Implications and Perceptions of African American Men who Used Ritalin as Children." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5446.
Full textČipkienė, Erika. "Narkotikų prevencijos, organizuojant ugdymo procesą, teorinis ir empirinis pagrindindimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090629_134854-01551.
Full textThe object of the master Degree paper, ”Drug Abuse Prevention in Education process, Theoretical and Empirical Foundation”, written by Erika Cipkiene, is the role of preventive activity when organizing the teaching process in secondary co-educational schools. The work analyses the resources that deal with the information on drug addiction issue and the possible prevention means when organizing educational process; the issues of drug abuse and the spread of drugs at schools in Lithuanian and other European countries are also analyzed the work also aims to find the ways how students, teachers and students’ parents could be involved in the prevention program. The empirical part of the work is dedicated to reveal teachers’ and students’ attitude towards prevention activity organization at school, highlighting the possible preventative actions and factors that determine success. The research was carried out collecting the a type data-a questionnaire was given to secondary school and gymnasium students and teachers. The respondents included 124 teachers and 246 students from various schools in Vilnius .the research revealed the difference between students’ and teachers’ attitude towards the need and priorities of prevention activity in secondary schools. Prevention activity is considered to be more significant by teachers. The research showed a wide variety of preventive means and opportunities, however, not all of them prove to be highly effective-both, students and teachers... [to full text]
Kuno, Ai. "Growing up with one parent: its association with psychotropic drug use in young adulthood : A register-based study in Sweden." Thesis, Stockholms universitet, Centrum för forskning om ojämlikhet i hälsa (CHESS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-132258.
Full textSloss, Ian. "The effects of ethanol on memory and neuroplasticity in a vertebrate and an invertebrate model of learning." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/65381/.
Full textShirama, Flavio Hiroshi. "Estudo de prevalência e caracterização do consumo de psicofármacos por pacientes internados em clínicas médica e cirúrgica de um hospital geral." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/22/22131/tde-05112012-163834/.
Full textCurrently, psychotropic drugs have shown high prevalence rates of consumption by the population. Aiming to provide subsidies for formulation of strategies of security management in the use of these drugs, this study aimed to identify, among patients hospitalized in medical and surgical clinics of a general hospital, the prevalence of psychotropic use and analyze the relationship between the use of these drugs and the demographic, socioeconomic and pharmacotherapeutics variables, with the health history and the result of applying the SRQ-20. A cross sectional study with descriptive correlational design and quantitative approach was performed with 93 patients in the clinics. For data collection, an interview guided by a questionnaire involving the study variables and by the SRQ-20 (Self-Reporting Questionnaire) was used for the detection of common mental disorders. Then, the records of these patients were checked, looking for the presence of psychotropic prescription. To evaluate the influence of independent variables on the consumption of psychotropic drugs, statistical associations were investigated using Chi-square test. To estimate the prevalence ratio was used the simple and multiple log-binomial regression models. The model fit was achieved using the PROC GENMOD procedure of SAS software version 9.0. It was observed the prevalence of 38.71% of psychotropic drug users, showing the association between the use of psychiatric drugs and sex, cost of hospitalization, religion and positive result on the SRQ-20. Benzodiazepines were the most consumed psychotropic drugs by the individuals of the sample (64%), followed by antidepressants (32%). The indications of benzodiazepines reported by patients were: \"to sleep\" (54%), for \"depression\" (14%), and \"anxiety\" (7%). The main indication of antidepressants was \"depression\" (50%). It was found that 25% and 22% of the patients were taking, respectively, benzodiazepines and antidepressants, without having knowledge of this fact. It was found that 70% of prescriptions of psychotropic drugs were performed by physicians non-psychiatrists, and the most prescribed by non-psychiatrists were benzodiazepines and the most prescribed by psychiatrists were antidepressants. Among the patients using psychotropic drugs, 59% performed only pharmacological treatment, 27.8% had a diagnosis of mental disorder, 36.1% had positive outcome, and 36.1% had negative outcome in the SRQ- 20. Self-medication was identified in 5% of patients. It is expected that this research contributes to arouse the concern related to this theme required for the improvement of information that should be considered by health professionals regarding treatment with psychotropic drugs and to implement strategies aimed at the rational use of medicines.
Lövheim, Hugo. "Psychotropic and analgesic drug use among old people : with special focus on people living in institutional geriatric care." Doctoral thesis, Umeå universitet, Institutionen för samhällsmedicin och rehabilitering, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1608.
Full textBlankert, Bertrand. "Développement de méthodes électroanalytiques hybrides pour l'étude de la biotransformation des médicaments." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210863.
Full textNotre champ d'investigation s'est plus spécifiquement focalisé sur deux familles de molécules psychotropes (les phénothiazines, et une dibenzoazépine). Celles-ci connaissent un usage thérapeutique intensif et un regain d’intérêt pour des applications nouvelles, mais leur utilisation optimale souffre de l’existence d'effets secondaires physiopathologiques importants et dont l’étiologie est encore mal connue.
En premier lieu, les résultats de la voltampérométrie cyclique et les différentes modulations en ligne d'une cellule électrochimique couplée à la détection par spectrométrie de masse, nous ont permis de mettre en évidence des différences essentielles dans le devenir des phénothiazines quant aux produits d'oxydations générés. Plus précisément, un comportement clairement distinct entre les phénothiazines garnies de deux (2C) ou trois carbones (3C) entre les deux azotes au niveau de leur chaîne latérale a pu être mis en évidence. Les phénothiazines 3C s'oxydent de manière classique en leur sulfoxyde correspondant. Par contre, les phenothiazines 2C, conjointement à la formation de leur sulfoxyde, souffrent dans des conditions énergiques d’oxydation (persulfate, potentiel élevé) d'une rupture de la chaîne latérale et libèrent la phénothiazine base aisément oxydable et donc subissant elle-même une oxydation. Au vu des structures moléculaires en trois dimensions, nous émettons l’hypothèse que volume trop important de la chaîne latérale des phénothiazines 2C empêcherait le déploiement aisé des structures aromatiques en un radical cation coplanaire lors du phénomène d'oxydation. Les tensions intrastructurelles apparues conduiraient au bris de la chaîne latérale. Différents modes d'oxydation (chimique, électrochimique, enzymatique) ont été utilisés et laissent chacun apparaître la dépendance directe entre la puissance de l'agent oxydant appliqué et les produits d'oxydation obtenus. Chaque technique de détection, de manière individuelle, a bien confirmé la dualité entre les deux groupes de molécules. La mise en commun des divers résultats nous a permis l'identification irrévocable des espèces intermédiaires instables et des composés finaux. Par corollaire, nous avons pu postuler un schéma général d'oxydation pour les dérivés phénothiaziniques. Il nous paraît intéressant de transposer nos résultats aux biotransformations des phénothiazines car les produits identifiés ne possèdent pas l'activité pharmacologique du composé parent mais présentent un profil toxicologique bien répertorié dans la littérature. Nos résultats suggèrent d’approfondir les études de biotransformation afin de déterminer si ‘l’éclatement’ oxydatif des phénothiazines 2C est également observé in vivo. Une relation cause/effet de ces métabolites pourrait ainsi être établie.
En deuxième point, au travers de l'association CE/SM ou CE/CL/SM, nous avons étudié l’électroxydation de la clozapine. La génération et l'identification des principaux métabolites de phases I et II, illustre un mimétisme certain avec le CYP450, et nous a permis de confirmer de nombreuses données de la littérature quant à l'oxydation in vivo et in vitro de la clozapine. L'oxydation électrochimique ne génère cependant pas l'ensemble des réactions de métabolisation prises en charge par le système CYP450. Lors de la combinaison CE/SM, par l'absence de séparation chromatographique dans cette configuration, le spectre de masse présente un pic correspondant à un intermédiaire à demi-vie courte, difficilement et rarement mis en évidence: l'ion nitrénium. Cette espèce hautement réactive envers les fonctions thiols des petites molécules et des protéines, se trouve très régulièrement tenue pour responsable majeur de la toxicité avérée de la clozapine.
L'apparition plus abondante de dérivés déméthylés démontre l'influence du potentiel appliqué à l'électrode de travail lors de l'oxydation électrochimique. En effet, les processus de déméthylation nécessitent des potentiels élevés pour être observés. En présence de glutathion, aux différents pics antérieurement identifiés, des pics supplémentaires relatifs à la formation d'adduits de GSH sur la CLZ apparaissent. Les courbes voltampérométriques réalisées sur la clozapine suggèrent la distinctement la formation de l'ion nitrénium et d'une nouvelle espèce aisément électroréduite, probablement une structure quinone imine. L'addition de GSH provoque la disparition des pics de réduction de la CLZ. Ces comportements en VC corroborent les interprétations issues des mesures par couplage EC/CL/SM.
La dernière partie de notre travail a consisté en la construction d'un biocapteur à pâte de carbone solide avec inclusion au sein de cette matrice de peroxydase de raifort. Basé sur la capacité reconnue de l'HRP à reproduire in vitro des produits d'oxydation similaires à la métabolisation in vivo, nous avons exploité un tel biocapteur pour l'analyse de la clozapine et de composés thiols. Une compréhension fine du mécanisme opérationnel intrinsèque du biocapteur a pu être suggérée. La génération à la surface de l'électrode de l'ion nitrénium par oxydation enzymatique de la clozapine par l'HRP, suivie de sa réduction immédiate fournit un courant ampérométrique substantiel. Sous des conditions de pH optimales, ce courant de réduction autorise la détermination quantitative de la clozapine dans un domaine de linéarité compris entre 1 x 10-5 M et 1 x 10-6 M. L'addition de composés thiols dans le milieu occasionne une chute de courant par action de ceux-ci sur la structure radical cation ou nitrénium par addition nucléophile. La disparition de l'ion nitrénium et la formation d'un adduit GSH-CLZ inhibent tout processus de réduction à l'électrode du biocapteur. Cette diminution de courant proportionnelle aux concentrations en thiols introduits, permet la détermination quantitative de dérivés thiols. Les courbes de calibration exprimées en pourcentage d'inhibition conduisent facilement à l'évaluation de la constante d'inhibition (Ki) et de CI50. L'étude de la réponse ampérométrique de la clozapine à l'EPC/HRP en l'absence ou présence d'un dérivé thiol envisagé permet la détermination de Km et de caractériser le type d'inhibition qui entre en jeu. De tels paramètres cinétiques nous ont habilités à classer les thiols considérés en fonction de leur puissance réactionnelle envers les substances oxydées de la clozapine.
Au terme de ce travail, nous espérons avoir illustré, par l’étude de quelques molécules modèles, l’intérêt de la mise en œuvre des techniques électrochimiques couplées à l’élément biologique ou à la spectrométrie de masse. Des améliorations au niveau de la cellule électrochimique sont envisageables par l’emploi d’électrodes modifiées, elles laissent entrevoir la possibilité de mimer totalement le système CYP450.
Les résultats fournis par ces techniques hybrides et par voltampérométrie cyclique sont complémentaires, ils procurent un éventail d'informations d'une utilité estimable pour une application dans des études prédictives précoces de candidats médicament.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
Schmidt, Karl F. "Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/114.
Full textEtchepare, Fanny. "Etude du respect des recommandations de prescription et d'utilisation des médicaments psychotropes chez les sujets âgés en France." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0200/document.
Full textDespite a high frequency of use and a tendency to present with adverse events of drugs, few studies assessed compliance with guidelines related to proper use of psychotropic drugs in the older population. The aim was to assess the patterns of psychotropic drugs use in this population, as well as the compliance with French guidelines. Two population samples were included, a clinical sample of older psychiatric inpatients and a sample of the older general population using claims database of the national health insurance. In clinical population, compliance with guidelines was rather good, with prescription of a short half-life benzodiazepine in nearly three quarters of prescriptions and adequate dosage in nearly two third of cases. However, treatment discontinuation was never specified at the time of treatment initiation and rhythm of prescription was discontinuous in only one third of cases. In the older general population, duration of antidepressant treatment and biological monitoring was appropriate in only 20 % of patients, whereas nearly three quarters of subjects initiating a benzodiazepine treatment were treated over an appropriate duration. However, less than half of them had received a benzodiazepine anxiolytic of short half-life. The assessment of the impact of practice guidelines publication found no improvement of psychotropic drugs use. Other interventions should accompany guidelines publication in order to underline the importance of proper use of drugs, particularly antidepressant treatment duration and use of short half-life benzodiazepine drugs
Couto, Fernanda Rocha. "Uso de psicotrópicos em policiais militares." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5701.
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INTRODUCTION: Being a military police is stressful. The responsibility for providing security to society brings a health hazard, threats to his / her health and safety. The fear of not coming back home alive or even hurt can lead to anxiety and stress. The search for immediate relief increases the use of psychotropic drugs by the military police. Studies published until now that approached this theme showed methodological limitations. AIMS: To evaluate the use of psychotropic drugs of list B1 (Clonazepam, Bromazepam and Alprazolam) by military police of Goiás State, to identify the group age and gender that used it most, to quantify the time of military police service that they used the psychotropic and to evaluate the proportion of this use according to the military personnel (soldiers and officers). METHODS: A review article was written based on data published between 1990 and 2013 in PubMed and SciElo. Thereafter, and observational, descriptive and retrospective study was done. One hundred military police from Hospital of Military Police in Goiânia city were evaluated by collecting the data presented in medical prescriptions and corporate pharmacy database using a form specially designed for this. INCLUSION CRITERIA: All the controlled B1 prescriptions in 2011. EXCLUSION CRITERIA: Illegible prescriptions, other controlled prescriptions like C1 and patients that are dependent of military police. RESULTS: The frequency of use was divided according to: 1) Genre: men (68%), women (32%); 2) Age: 18 to 35 years old (4%); 36 to 50 years old (52%); 51 to 70 years old (12%); >71 years old (3%); uninformed (29%); 3) Psychotropics: Alprazolam (14%), Bromazepam (13%), Clobazam (1%), Clonazepam (53%), Cloxazolam (7%), Diazepam (1%), Flurazepam (1%), Midazolam (2%), Nitrazepam (7%);4) Trimester: Jan/Mar (22%), Apr/June (39%), July/Sept (31%), Oct/Dec (7%); 5) Service time:<5 years old (2%), 6 to 10 years old (5%), 11 to 20 years old (12%), 21 to 30 years old (48%); 6) Military rank: soldier (63%), officers (11%), pensionary (2%), uninformed (24%). CONCLUSION: The profile of the military police user of psychotropic drugs was female sex with an average age of 47. The most common psychotropic drug was Clonazepam. The service time when they most use the drugs was the one comprehended between 21 and 30 years of activity in the military force. From the Military Police personnel, there was no difference in relation to military officers.
INTRODUÇÃO: A profissão de policial por si só é uma profissão muito estressante. A responsabilidade de proporcionar à sociedade segurança traz uma perigosidade. O homem/mulher dentro da farda colocam a vida em risco. O medo de não voltar para casa com vida ou mesmo ferido acaba proporcionando alto nível de estresse e ansiedade. A busca por alívio imediato aumenta o uso de medicamentos psicotrópicos por policiais e outras profissões com alto nível de estresse. Os estudos que investigaram o tema apresentam limitação metodológica. OBJETIVOS: Avaliar o uso de medicamentos psicotrópicos controlados da Lista B1(Clonazepam, Bromazepam e Alprazolam) em policiais militares do estado de Goiás, identificar a faixa etária e o gênero que mais utilizou os psicotrópicos, identificar o psicotrópico B1 mais utilizado pelo policial militar do estado de Goiás, quantificar o tempo de serviço do policial militar que fez uso com maior assiduidade dos medicamentos psicotrópicos e avaliar a proporção do uso de psicotrópicos segundo o quadro de composição militar (praças e oficiais). CRITÉRIOS DE INCLUSÃO: Todos os receituários controlados B1 de 2011. CRITÉRIOS DE EXCLUSÃO: receituários ilegíveis, receituários de controle especial C1 e pacientes dependentes do policial militar. MÉTODOS: Foi redigido um artigo de revisão da literatura, construído a partir de pesquisas nas bases de dados PubMed/Medline e SciElO entre 1990 e 2013. Em seguida foi elaborado este estudo observacional, descritivo e retrospectivo. Foi desenvolvido com a coleta de dados de 100 receituários escolhidos aletoriamente de policiais atendidos na Farmácia Fundação Tiradentes no Hospital do Policial Militar no município de Goiânia. Foi utilizado formulário elaborado pelo pesquisador e orientador. Os dados foram coletados de receituários controlados B1 arquivados na Farmácia e sistema da corporação, após autorização do estabelecimento. RESULTADOS: A frequência de uso foi dividida em: 1) Gênero: homens - (68%), mulheres (32%); 2) Idade: de 18 a 35 anos (4%); 36 a 50 anos (52%), 51 a 70 anos (12%), > 71 anos (3%), não informado (29%); 3) Psicotrópicos: Alprazolam (14%), Bromazepam (13%), Clobazam (1%), Clonazepam (53%), Cloxazolam (7%), Diazepam (1%), Flurazepam (1%), Midazolam (2%), Nitrazepam (7%). 4) Trimestre: jan/mar (22%), abr/jun (39%), jul/set (31%), out/dez (7%), 5) Tempo de serviço: < 5 anos (2%), 6 a 10 anos (5%), 11 a 20 anos (12%), 21 a 30 anos (48%); 6) Patente: praça (63%), oficial (11%), pensionista (2%), não informado (24%). CONCLUSÃO: A idade média foi de 47,03 e o gênero proporcionalmente que mais usou o psicotrópico foi o sexo feminino, sendo o Clonazepam o mais utilizado. Observou-se ainda que o tempo de serviço militar, entre 21 e 30 anos, contribuiu para o uso. Não houve diferença em relação a patente de Praça e Official.