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Dissertations / Theses on the topic 'Psychotropic drugs – adverse effects'

Author: Grafiati
Published: 26 July 2024
Last updated: 31 July 2025

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1

Attoh, mensah Kouakou. "Risques de chutes et de troubles cognitifs consécutifs à la consommation de certains médicaments chez les seniors : approche translationnelle Psychotropic Polypharmacy in Adults 55 Years or Older: A Risk for Impaired Global Cognition, Executive Function, and Mobility Adverse Effects of Anticholinergic Drugs on Cognition and Mobility: Cutoff for Impairment in a Cross-Sectional Study in Young-Old and Old-Old Adults : Chronic tramadol administration impairs reversal learning in a touchscreen-based visual discrimination task in mice." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC427.

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Les psychotropes et les médicaments à propriétés anticholinergiques (anti-muscariniques) ont été associés aux risques de chute et de troubles cognitifs chez les séniors. Nos travaux avaient pour but de mieux comprendre le rôle de ces médicaments dans les phénomènes de troubles de la mobilité et de troubles cognitifs. Dans un premier temps, nous avons montré que la consommation de 2 psychotropes ou plus par jour et/ou d’1 seul médicament à propriétés anticholinergiques par jour, dès la charge anticholinergique minimale, est associée à un déficit lors de tests d’évaluation de la marche et de la
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2

Purcell, Gregory Mark. "Intervention to improve the level of documentation of antipsychotic related adverse drug reactions." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/10340.

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Antipsychotic drugs are the mainstay of treatment for psychotic disorders according to the Standard Treatment Guidelines (2012). However, these drugs are associated with multiple severe adverse drug reactions. In order to limit the effect of adverse drug reactions on patient care, documentation is necessary. Documentation of adverse drug reactions entails recording the reaction experienced, as well as supplementary information. Proper documentation can prevent future occurrences of the same or similar adverse drug reactions. The aim of this study was to determine the effects of an educational
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3

Melkersson, Kristina. "Influence of antipsychotic drugs on hormone levels /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4089-4/.

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4

Rodgers, Amie D. Rusyn Ivan. "Modeling adverse liver effects of drugs using kNN QSAR method." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2463.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Masters of Sciences in the School of Medicine Toxicology." Discipline: Toxicology; Department/School: Medicine.
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Lau, Phyllis Min-yu. "Adverse drug reactions in oncology." Monash University, Dept. of Pharmacy Practice, 2003. http://arrow.monash.edu.au/hdl/1959.1/5549.

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6

Lefever, Timothy W. "Effects of olanzapine on olfactory delayed matching-to-sample in rats." View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-3/lefevert/timothylefever.pdf.

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7

Wieliczko, Monika J. "Psychological effects of MDMA." Thesis, Canterbury Christ Church University, 2016. http://create.canterbury.ac.uk/14928/.

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Zinberg's Interaction Model implies that the content of a drug-induced experience is a function of the pharmacological properties of the drug, the set (the user’s characteristics e.g. motivation and personality), and the setting (the physical and social context). The current research investigated the function of the set and setting and their role in shaping the psychological effects of 3,4-methylenedioxmethamphetamine (MDMA), as well as their role in reducing the risk of drug abuse. An online survey was distributed among adult MDMA polydrug users (n = 158) and MDMA-naïve controls (alcohol, nic
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Tamm, Leanne. "Single and combined effects of stimulant medication and contingencies on the cognitive performance of children with attention deficit hyperactivity disorder /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004383.

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9

Gunter, Bryan R., Kristen A. Butler, Richard L. Wallace, et al. "NSAIDs-induced Cardiovascular Adverse Effects: A Meta-analysis." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/95.

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10

Wang, Yu-Chin Lily. "Postmarketing surveillance of sumatriptan : patient population, efficacy, and adverse effects." Scholarly Commons, 1994. https://scholarlycommons.pacific.edu/uop_etds/2273.

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A postmarketing surveillance survey of sumatriptan use comprised 32 questions including patient demographics, headache history, and sumatriptan experience. One hundred and forty-one questionnaires were sent out, and 109 patients responded; a total of 108 patients were included in the data analysis. When compared with the national migraine population, on a percentage basis, significantly more African-Americans, females, young patients (less 45 years of age), and patients with higher mean incomes (>$45,000) were found in the present study of those taking sumatriptan (p Males (N=8) and females (N
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11

Mutenda, Nicholus Mbangu. "Adverse effects experienced by patients on first line antiretroviral drugs used at Keetmanshoop Hospital (Namibia)." University of the Western Cape, 2015. http://hdl.handle.net/11394/4549.

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>Magister Scientiae - MSc<br>Adverse effects are a significant factor that determine how long patients will tolerate a given antiretroviral drug regimen. They also influence treatment options, and play an important role in the much needed adherence to treatment by patients on Highly Active Antiretroviral Therapy (HAART). This study is aimed at understanding adverse effects experienced by patients on the first line antiretroviral therapy at Keetmanshoop Hospital in Namibia. Methods : A retrospective quantitative method was used to review records of patients on first line antiretroviral treat
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12

Darin, Areechokchai Wirach Maek-a.-nantawat. "Adverse effects of antiretroviral drugs during pregnancy : A five-year review at Chonburi Hospital, Thailand /." Abstract, 2007. http://mulinet3.li.mahidol.ac.th/thesis/2550/cd400/4938552.pdf.

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Thematic Paper (M.C.T.M. (Clinical Tropical Medicine))--Mahidol University, 2007.<br>LICL has E-Thesis 0024 ; please contact computer services. LIRV has E-Thesis 0024 ; please contact circulation services.
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13

Kunac, Desirée L., and n/a. "Adverse drug events and medication errors in a paediatric inpatient population." University of Otago. Dunedin School of Medicine, 2005. http://adt.otago.ac.nz./public/adt-NZDU20060707.161220.

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Background. Medication-related patient injuries (adverse drug events, ADEs) are an important problem in all hospitalised populations; however, the potential for injury is reported to be greater in children than adults. Many ADEs are due to error and therefore could be prevented. Data regarding the risk factors (or predictors) for these events in paediatric inpatients is limited. It was hypothesised that "identification of risk factors for ADEs and medication errors in the paediatric inpatient setting will inform likely prevention strategies". Aims. To determine the frequency, nature and risk
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14

Pooviboonsuk, Prakob. "An investigation of the relationship between event-related potentials (ERPs) and the amnesiac and sedative effects of psychotropic drugs." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339129.

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15

Gouws, Stephanus Andries. "The impact of hospital surveillance programmes on the incidence of adverse drug reaction reporting in a South African teaching hospital." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27186.

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Post-marketing surveillance refers to any non-experimental or observational study, method, or monitoring strategy that is applied to obtain information on drug experience (primarily adverse) after a drug has been approved for clinical use. One of the major problems in post-marketing surveillance studies is the lack or under-reporting of drug experiences by health care professionals. This study was developed to describe the impact of three different prescription event monitoring programmes on the reporting of adverse drug reactions (ADR's) in the hospital situation. The intensive ADR monitoring
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16

Sloss, Ian. "The effects of ethanol on memory and neuroplasticity in a vertebrate and an invertebrate model of learning." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/65381/.

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Binge drinking is characterised by cycles of ethanol intoxication and withdrawal and is thought to be highly deleterious for the normal functioning of the nervous system. The behavioural and neurophysiological consequences of rapid escalation of blood alcohol concentration and subsequent withdrawal, and their effects on learning and memory and underlying neural circuitry can be studied in suitable animal models. Here, spatial and instrumental learning as well as hippocampal LTP were assessed in C57BL/6J mice for the effects of adolescent intermittent ethanol (AIE) and other ethanol treatments.
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17

O'Brien, Michelle University of Ballarat. "A study of multiple perspectives and knowledge in adverse drug reaction decision-making : Volume 1." University of Ballarat, 2004. http://archimedes.ballarat.edu.au:8080/vital/access/HandleResolver/1959.17/12769.

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Injury and illness associated with drugs are major problems in Australia and around the world, despite significant developments in the area of adverse drug reaction (ADR) decision support technology. The aims of this thesis are: to investigate the ADR decision domain; to determine factors that may assist in the prevention, detection and management of ADRs; and, to inform the pre-requirements analysis phase of the development of decision support systems. An approach has been taken that permits open and grounded study of the decision environment. This approach can then be used to frame and infor
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O'Brien, Michelle. "A study of multiple perspectives and knowledge in adverse drug reaction decision-making : Volume 1." Thesis, University of Ballarat, 2004. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/36308.

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Injury and illness associated with drugs are major problems in Australia and around the world, despite significant developments in the area of adverse drug reaction (ADR) decision support technology. The aims of this thesis are: to investigate the ADR decision domain; to determine factors that may assist in the prevention, detection and management of ADRs; and, to inform the pre-requirements analysis phase of the development of decision support systems. An approach has been taken that permits open and grounded study of the decision environment. This approach can then be used to frame and infor
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O'Brien, Michelle. "A study of multiple perspectives and knowledge in adverse drug reaction decision-making : Volume 1." University of Ballarat, 2004. http://archimedes.ballarat.edu.au:8080/vital/access/HandleResolver/1959.17/14606.

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Injury and illness associated with drugs are major problems in Australia and around the world, despite significant developments in the area of adverse drug reaction (ADR) decision support technology. The aims of this thesis are: to investigate the ADR decision domain; to determine factors that may assist in the prevention, detection and management of ADRs; and, to inform the pre-requirements analysis phase of the development of decision support systems. An approach has been taken that permits open and grounded study of the decision environment. This approach can then be used to frame and infor
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20

Lomas, Amy. "The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/20475.

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Master of Science<br>Department of Clinical Sciences<br>Gregory F. Grauer<br>Prostaglandins play many important roles in the kidney including regulation of renal blood flow, glomerular filtration, renin release, and sodium excretion. Upon activation of the renin angiotensin aldosterone system (RAAS), prostaglandin upregulation becomes critical to offset the vasoconstrictive effects of norephinephrine, angiotensin II, and vasopressin. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce both their beneficial and detrimental effects through inhibition of the cyclooxygenase enzyme and subse
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21

O'Connor, Eoin. "Investigations into the role of the metabotropic glutamate receptor, mGluR5, in incentive learning and some behavioural and neurobiological effects of cocaine." Thesis, University of Sussex, 2011. http://sro.sussex.ac.uk/id/eprint/6981/.

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The metabotropic glutamate receptor, mGluR5, is densely expressed in brain regions involved in incentive learning processes. There is considerable evidence to suggest that following exposure to addictive drugs such as cocaine, adaptations in these brain areas may underlie the development and maintenance of behavioural responses related to addictive processes. The present thesis examines the role of mGluR5 in both incentive learning processes and some behavioural and neurobiological effects of cocaine. First, using a novel mutant mouse line in which mGluR5 is selectively knocked down in cells t
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22

Sylvestre, Marie-Pierre. "Flexible modelling for the cumulative effects of time-varying exposure, weighted by recency, on the hazard." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111917.

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Many epidemiological studies assess the effects of time-dependent exposures, where both the exposure status and its intensity vary over time. The analysis of such studies poses the challenge of modelling the association between complex time-dependent drug exposure and the risk, especially given the uncertainty about the etiological relevance of doses taken in different time periods.<br>To address this challenge, I developed a flexible method for modelling cumulative effects of time-varying exposures, weighted by recency, represented by time-dependent covariates in the Cox proportional hazards
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23

Azarbayjani, Faranak. "Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5065-2/.

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24

Davidson, Melissa Anne. "A Pharmacovigilance Approach for Assessing Cardiovascular, Osteological, and Carcinogenic Risk Associated with Thiazolidinedione Drugs Used in the Treatment of Type 2 Diabetes Mellitus." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38062.

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Diabetes is a chronic and debilitating disease that affects nearly half a billion people worldwide with the vast majority of diabetics suffering from Type 2 diabetes mellitus (T2DM), a disease characterized by insulin insensitivity that often requires pharmacotherapy to effectively maintain target blood sugar levels. The thiazolidinedione (TZD) class of drugs consists of oral hypoglycaemic agents used alone or in combination with other antidiabetic drugs to treat T2DM. The drugs within this class, which include rosiglitazone and pioglitazone, were originally heralded as providing novel first a
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25

Cunha, Eva Sofia Gonçalves da. "Avaliação dos efeitos secundários dos fármacos quimioterápicos em animais de companhia : estudo retrospetivo." Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2014. http://hdl.handle.net/10400.5/7615.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>A quimioterapia é uma modalidade terapêutica usada em oncologia, cujo objetivo passa pela total erradicação das células tumorais ou pela cura, através da administração de fármacos quimioterápicos ou anti-neoplásicos. Estes atuam, na sua grande maioria, em células com elevado índice mitótico, atingindo não apenas as células neoplásicas como também as células normais, o que conduz aos chamados efeitos secundários. Este estudo teve como objetivo a avaliação e caracterização dos efeitos secundários dos fármacos quimioterápicos, na prátic
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26

Joshi, Paliza. "Use of cognitive enhancing substances by University students: a cross-sectional study." Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/361.

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Objectives: The purpose of this study was to determine the prevalence and patterns of use of cognitive enhancing substances (such as caffeine containing products and beverages and prescription stimulant drugs) amongst students at Curtin University. Further, to determine the potential for adverse effects from their use.Method: A cross-sectional study was conducted involving students attending the Curtin University. A sample of students was randomly selected and students were presented with an information sheet explaining the purpose and design of the study as well as their role in the study. On
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Branco, Klébia Magalhães Pereira Castello. "Análise clínica evolutiva do uso do tacrolimus como droga imunossupressora em transplante cardíaco pediátrico." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-24052011-163915/.

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O Tacrolimus é uma potente droga imunossupressora introduzida no transplante cardíaco no início da década de 90. Pacientes com rejeição refratária ou intolerância à ciclosporina podem responder à terapia de resgate com o tacrolimus. Os objetivos deste estudo foram: avaliar a evolução clínica das crianças submetidas ao transplante cardíaco que necessitaram da conversão de ciclosporina para tacrolimus por rejeição refratária, tardia ou efeitos adversos de difícil controle; avaliar a incidência de rejeição após a conversão para o tacrolimus e comparar a sobrevida dos pacientes em uso de tacrolimu
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Paizinho, Ana Filipa Diogo da Rocha. "Efeitos secundários da quimioterapia antineoplásica e o seu impacto na qualidade de vida dos animais de companhia." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2021. http://hdl.handle.net/10400.5/21663.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>O aumento da esperança de vida dos animais de companhia favorece um crescimento no número de casos de doença oncológica, havendo, desta forma, cada vez mais donos que optam pelo tratamento quimioterápico, visando o prolongamento da vida dos seus animais. No entanto, a utilização destes compostos está, inevitavelmente, associada a toxicidade em diversos sistemas do organismo, levantando dúvidas relacionadas com a manutenção da qualidade de vida dos animais. Neste contexto, pretendeu-se, com este trabalho, quantificar os efeitos advers
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Hirota, Adriana Sayuri. "Análise do suporte ventilatório mecânico durante anestesia e sua correlação com as complicações pulmonares pós-operatórias: um estudo observacional." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-02102014-111242/.

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Introdução: A formação de atelectasia durante a indução anestésica pode ser um dos fatores responsáveis pela ocorrência de complicações pulmonares pós-operatórias (CPP). A aplicação de pressão positiva expiratória ao final da expiração (PEEP), uso criterioso de altas frações inspiradas de oxigênio e a utilização de manobras de recrutamento alveolar no período intra-operatório são recursos utilizados para a prevenção de atelectasia em procedimentos anestésicos. O objetivo deste estudo foi avaliar o modelo de ventilação mecânica adotado em procedimentos anestésicos de longa duração e suas correl
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Marodin, Gabriela. "Riscos de eventos adversos gastrintestinais nos projetos de pesquisa de fármacos envolvendo seres humanos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/14955.

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A avaliação do risco é um processo sistemático pelo qual a possibilidade de dano, a exposição e o próprio risco são identificados e quantificados. A consideração, de que a participação em um estudo é de risco, fundamenta-se no princípio da precaução, que é a garantia da existência de medidas de proteção contra riscos potenciais. De acordo com a gravidade dos eventos adversos, e de sua probabilidade de ocorrência, determina-se se o risco previsto é negligenciável, tolerável ou intolerável. Portanto, a caracterização do risco representa um importante elo entre os dados científicos obtidos nos di
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Amaral, Renata Teixeira do. "Avaliação dos níveis plasmáticos e possíveis alterações clínico-laboratoriais em pacientes portadores de hipertensão arterial sistêmica na terapia com nifedipina." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-29012018-101149/.

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A nifedipina atua como bloqueador de canais de cálcio inibindo o fluxo transmembrânico de ions Ca2+ no interior das células do músculo cardíaco e células do músculo liso vascular, o qual induz ao relaxamento do músculo liso e diminuição da resistência vascular periférica. É utilizado no Brasil no tratamento de hipertensão arterial sistêmica (HAS), faz parte da Relação Nacional de Medicamentos Essenciais do Ministério da Saúde e vem sendo distribuída pela Secretaria da Saúde do Estado de São Paulo. Uma vez que a determinação plasmática do fármaco contribui para maior segurança de seu uso, o obj
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Alassaad, Anna. "Improving the Quality and Safety of Drug Use in Hospitalized Elderly : Assessing the Effects of Clinical Pharmacist Interventions and Identifying Patients at Risk of Drug-related Morbidity and Mortality." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234488.

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Older people admitted to hospital are at high risk of rehospitalization and medication errors. We have demonstrated, in a randomized controlled trial, that a clinical pharmacist intervention reduces the incidence of revisits to hospital for patients aged 80 years or older admitted to an acute internal medicine ward. The aims of this thesis were to further study the effects of the intervention and to investigate possibilities of targeting the intervention by identifying predictors of treatment response or adverse health outcomes. The effect of the pharmacist intervention on the appropriateness
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Vargas, Rafael Arêas. "Efeito crônico da administração de esteróide anabólico androgênico na próstata de ratos." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5235.

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Esteróides anabólicos androgênicos (EAA) são usados por atletas profissionais e amadores, com o objetivo de melhorar a capacidade atlética, aparência e massa muscular. Muitos efeitos adversos têm sido associados com o abuso de EAA, incluindo doenças do trato urogenital. Este estudo teve como objetivo avaliar as alterações morfológicas no lobo ventral da próstata de ratos púberes e adultos cronicamente tratados com doses suprafisiológicas de EAA, usando métodos morfométricos. Foram estudados 39 ratos Wistar machos pesando entre 400 e 550 g. Os ratos foram divididos em quatro grupos: (a) ratos c
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Júnior, Altamiro Ribeiro Dias. "Efeitos das terapêuticas com estrogênios eqüinos conjugados ou raloxifeno sobre a rigidez arterial em mulheres na menopausa." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-03102014-143049/.

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INTRODUÇÃO: A rigidez arterial é fator de risco cardiovascular pouco estudado e importante determinante de sobrecarga cardiovascular, estando associada ao envelhecimento. Analisou-se a ação das terapêuticas com estrogênios eqüinos conjugados (EEC) ou raloxifeno sobre os índices de rigidez, com o intuito de se observar a influência destas medicações na rigidez arterial, bem como se as mesmas são capazes de influenciar o envelhecimento vascular bem sucedido. MÉTODOS: Realizou-se estudo duplo cego, randomizado, placebo-controlado, que envolveu sessenta e sete mulheres saudáveis, normotensas e com
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Dib, Ricardo Anuar. "Avaliação de sintomas e lesões esôfago-gastroduodenais secundários ao uso de antiinflamatórios." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-08112013-110643/.

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Introdução: Os antiinflamatórios não esteróides (AINEs), incluindo a aspirina, são drogas largamente utilizadas para tratamento das doenças inflamatórias e da dor, e que podem causar efeitos colaterais sérios, causando considerável morbidade e mortalidade, relacionadas á doença ulcerosa, duodenal e gástrica, particularmente ao sangramento gastrointestinal. O risco relativo global de complicações gastroduodenais é de três a dez vezes, maior nos usuários de AINEs, quando comparado com indivíduos sadios. Cerca de 25% dos usuários crônicos dos antiinflamatórios não esteroides (AINEs) deverão desen
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Fappi, Alan. "Efeitos do ácido graxo ômega-3 na prevenção da atrofia muscular induzida pela dexametasona." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-13012014-114428/.

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Várias condições podem estar associadas com a atrofia muscular, tais como inatividade, envelhecimento, septicemia, diabetes, câncer e uso de glicocorticoides. Todas estas condições levam a atrofia muscular através de mecanismos que incluem aumento da degradação proteica e/ou redução na síntese proteica, envolvendo pelo menos cinco sistemas: lisossomal, da calpaína, das caspases, metaloproteinases e o sistema ubiquitina-proteasoma (SUP). Glicocorticoides, tais como a dexametasona, acarretam atrofia muscular atuando em quase todos esses sistemas, com significante ativação do SUP e lisossomal, af
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Park, Chin S. "Adverse Outcomes Associated with Psychotropic Medication Usage in Nursing Homes." Thesis, 2016. https://doi.org/10.7916/D8WW7HV4.

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The elderly population is growing in nursing homes (NHs), with an estimated 3 million seniors to be residing in NH facilities by year 2030. Many of these seniors are potentially at risk for falls or infections. NH residents with Alzheimer’s disease or other forms of dementia are also increasing, and they are vulnerable to the adverse effects of medications. Psychotropics are overused in NHs, with approximately half to two thirds of residents receiving one or more psychotropics. Many negative health outcomes, e.g. falls and infections, have been associated with their use. The usage of p
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38

Novais, Sofia Alexandra Machado. "Predicting Adverse Effects of Drugs." Master's thesis, 2017. https://repositorio-aberto.up.pt/handle/10216/105434.

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The number of drugs currently available at the commercial level is quite large. The therapeutic importance and the benefit of these are indisputable. However, unknown effects of individual drugs and/or the interaction of effects between drugs may have serious consequences for the health of the population.The use of some drugs may prove to be unsafe and risky, since the response and interaction of the population to their use differ substantially. It is known that in practice and despite all measures taken during the premarketing phase they may be insufficient, since factors such as the patients
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39

Novais, Sofia Alexandra Machado. "Predicting Adverse Effects of Drugs." Dissertação, 2017. https://repositorio-aberto.up.pt/handle/10216/105434.

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The number of drugs currently available at the commercial level is quite large. The therapeutic importance and the benefit of these are indisputable. However, unknown effects of individual drugs and/or the interaction of effects between drugs may have serious consequences for the health of the population.The use of some drugs may prove to be unsafe and risky, since the response and interaction of the population to their use differ substantially. It is known that in practice and despite all measures taken during the premarketing phase they may be insufficient, since factors such as the patients
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40

Hsu, Ying-pao, and 許櫻寶. "Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Adverse Effects." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/86975680437062110382.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>97<br>Background NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) are among the most widely used medicines in the world. Unfortunately, they are associated with dose-dependent gastrointestinal adverse events ranging from dyspepsia (10–20%) to symptomatic and complicated ulcers (1–4%). Although clinical trial results suggest that coxibs has less gastrointestinal toxicity than most other non-steroidal anti-inflammatory drugs (NSAIDs), but not in meta-analysis. Objective To estimate whether preferential and selective coxibs have been channeled towards high risk pa
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41

"Adverse reaction of Chinese herbal medicines." 2003. http://library.cuhk.edu.hk/record=b5891440.

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Hin-Chung Chu.<br>Thesis submitted in: July 2002.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 281-306).<br>Abstracts in English and Chinese.<br>Cover (English & Chinese version) --- p.I<br>中文封面 --- p.II<br>Abstract (English version) --- p.III-IV<br>中藥不良反應論文摘要 --- p.V<br>Acknowledgements --- p.VI<br>Abbreviations --- p.VII-VIII<br>Publication in press --- p.IX<br>Content --- p.X-XV<br>Lists of Table --- p.XVI<br>Chapter Chapter 1 --- Introduction --- p.1-3<br>Chapter Chapter 2 --- Chinese herbal medicines used in Hong Kong
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Owo, Owo Ikwa. "Alcohol and other drugs: prevalence, demographic characteristics and perceived effects on the academic performance of high school students within the Mogalakwena Municipality of Limpopo Province." Master's thesis, 2013. http://hdl.handle.net/10539/12479.

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INTRODUCTION: Smoking, alcohol and other drugs use among high school learners has become a major public health problem across the globe. Here in South Africa, it is estimated that a large proportion of learners indulge in smoking and the use of alcohol and illicit drugs. Data from treatment sites across the country indicate that the number of patients who are below 20 years seeking treatment is escalating. These indulgences have been blamed for escalating school violence, rapes, robbery and accidents, all of which contribute to increased morbidity, disability and premature deaths. It is expect
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43

Chan, Yu-Min, and 陳昱旻. "The gastrointestinal adverse effects and prescribing patterns of nonsteroidal anti-inflammatory drugs." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/65266492031450233638.

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碩士<br>國立成功大學<br>臨床藥學研究所<br>84<br>Nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to be associated with an elevated risk of peptic ulcer and upper gastrointestinal hemorrhage. A retrospective cohort study was performed to estimate the incidence and cumulative incidence of serious ulcer disease among long-term users of NSAIDs, using a computerized prescriprion data base of National Cheng-Kung University Hospital. Twenty-eight thousand seven hundred and seventy four NSAID recipi
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44

Shih, Kai-Lun, and 施凱倫. "The influenced factors of the adverse effects from therapeutic drugs of chronic hepatitis C." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/sabq4v.

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碩士<br>長榮大學<br>醫學研究所<br>98<br>Background: The treatment effect of chronic hepatitis C (HCV) is often limited due to the adverse effects of interferon and ribavirin. Hemolytic anemia and hematological adverse effect may influence the treatment program. Previous studies documented Genotype I, hypertension, low baseline hemoglobin, and raised creatinine were factors associated with the development of hematological abnormalities. Aims: The study evaluate if some host factors, included oxidative stress and leukocyte mitochondrial DNA copy number before treatment are associated with severe hematologi
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45

"Effects of anti-osteoporosis drugs on human mast cells." 2010. http://library.cuhk.edu.hk/record=b5894450.

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Lee, Hoi Ying.<br>"September 2010."<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves 171-189).<br>Abstracts in English and Chinese.<br>Abstract (English) --- p.i<br>Abstract (Chinese) --- p.iii<br>Acknowledgement --- p.v<br>Publications --- p.vi<br>Abbreviations --- p.vii<br>Table of Content --- p.x<br>Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Human mast cells and its activation --- p.1<br>Chapter 1.2 --- Role of mast cells in inflammation --- p.2<br>Chapter 1.3 --- Mast cell heterogeneity --- p.5<br>Chapter 1.4 --
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46

Govender, Theshni. "Adverse gastrointestinal effects of over-the-counter non-steroidal anti-inflammatory drugs: a cost study in two Gauteng Public Hospital." Thesis, 2017. https://hdl.handle.net/10539/24737.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfillment of the requirements for the degree of Master of Medicine. Johannesburg 2017.<br>Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesics worldwide. NSAIDs are increasingly available as an expanding range of over the counter (OTC) and prescription formulations. Straube et al, in a systematic review, report the mortality rate of individuals with UGIT bleeding/perforation using chronic oral NSAIDs is 1 in 5 due to gastrointestinal complications. The eco
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Klapková, Tereza. "Současné poznatky o vlivu léčiv na mužskou fertilitu." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-411929.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Tereza Klapková Supervisor: Assoc. Prof. PharmDr. František Trejtnar, CSc. Title of diploma thesis: Recent knowledge on drug effect on male fertility Among the various types of side effects presented in clinically used drugs, negative effects on male reproductive functions can be find. This issue seems to be important and current especially due to the general trend of the decrease in fertility in men and the increasing drug use in younger age groups. The aim of this diploma thesis was
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Cunha, Margarida Maria Costa Guimarães. "Relatório de Estágio e Monografia intitulada "Prevenção da Transmissão Vertical do HIV"." Master's thesis, 2017. http://hdl.handle.net/10316/83801.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O Vírus da Imunodeficiência Humana (HIV) surgiu no final dos anos 70, tornando-se uma das doenças infeciosas mais devastadoras do século XX. Com o surgimento dos primeiros fármacos e com o início da era da Highly Active Antiretroviral Therapy (HAART) foi possível começar a inverter a tendência do número de novas infeções e atrasar a progressão da infeção, tornando, nos dias de hoje, o Síndrome da Imunodeficiência Adquirida (SIDA) uma doença crónica. No entanto, a infeção por HIV continua
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Matos, Joana dos Santos. "Perceção de Efeitos Adversos por Doentes Hipertensos e sua Relação com Não Adesão Voluntária à Terapêutica." Master's thesis, 2020. http://hdl.handle.net/10316/93033.

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Dissertação de Mestrado em Farmacologia Aplicada apresentada à Faculdade de Farmácia<br>IntroduçãoA Hipertensão Arterial é considerada um dos mais importantes fatores de risco da principal causa de mortalidade em Portugal e em todo o mundo: as doenças cérebro-cardiovasculares. Uma das principais variáveis que conduzem a um mau controlo da pressão arterial em doentes hipertensos é a falta de adesão à terapêutica. A adesão à terapêutica é influenciada por múltiplos fatores, que condicionam o seguimento das recomendações médicas relativas à toma da medicação, sendo um deles a presença de efeitos
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