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1

Muntaner, Carles, Lluis Garcia-Sevilla, Alberto Fernandez, and Rafael Torrubia. "Personality dimensions, schizotypal and borderline personality traits and psychosis proneness." Personality and Individual Differences 9, no. 2 (1988): 257–68. http://dx.doi.org/10.1016/0191-8869(88)90087-6.

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Adami, Helene, Richard Kunkel, Marianne Moran, Shawn Cassady, Yawei Zhou, David Ross, and Gunvant Thaker. "Psychosis proneness scales in schizophrenia spectrum personality disorders." Schizophrenia Research 15, no. 1-2 (April 1995): 5. http://dx.doi.org/10.1016/0920-9964(95)95023-3.

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3

Laurent, A. "Psychosis proneness scales and DSM schizophrenia spectrum personality disorders." European Psychiatry 17 (May 2002): 166. http://dx.doi.org/10.1016/s0924-9338(02)80721-0.

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Kumari, Veena, Elena Antonova, and Mark A. Geyer. "Prepulse inhibition and “psychosis-proneness” in healthy individuals: An fMRI study." European Psychiatry 23, no. 4 (June 2008): 274–80. http://dx.doi.org/10.1016/j.eurpsy.2007.11.006.

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AbstractObjectivePrepulse inhibition (PPI) of the startle response provides an operational index of sensorimotor gating that is reliably demonstrable in both human and animal subjects. Patients with schizophrenia, first-degree relatives of patients with schizophrenia, patients with schizotypal personality disorder and healthy individuals scoring high on psychometric measures of psychosis-proneness display reduced PPI. This study examined associations between individual differences in “psychosis-proneness” and brain activity during a tactile prepulse inhibition paradigm previously found to reveal activation in controls and deficient activation in schizophrenia patients in the striatum, thalamus, insula, hippocampal, temporal, inferior frontal, and inferior parietal regions.MethodsFourteen right-handed healthy men underwent psychophysiological testing and functional magnetic resonance imaging (fMRI) during a 15-min tactile PPI paradigm involving the use of tactile stimuli as both the pulse (a 40-ms presentation of 30 psi air-puff) and the prepulse (a 20-ms presentation of 6 psi air-puff presented 30-ms or 120-ms before the pulse). Individual differences in “psychosis-proneness” were assessed with Psychoticism scale of the Eysenck Personality Questionnaire-Revised (EPQ-R).ResultsHigh psychosis-proneness was associated with lower PPI and reduced activity in the inferior frontal gyrus, insula extending to putamen and thalamus, parahippocampal gyrus, and inferior parietal and middle temporal regions. No regional activity correlated positively with psychosis-proneness.ConclusionsThe present observations extend the findings observed previously in people with schizophrenia to people with high psychosis-proneness, providing support to continuum theories of psychosis with implications for understanding trait-related neural deficits in schizophrenia.
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Hay, David A., Nicholas G. Martin, Debra Foley, Susan A. Treloar, Katherine M. Kirk, and Andrew C. Heath. "Phenotypic and Genetic Analyses of a Short Measure of Psychosis-proneness in a Large-scale Australian Twin Study." Twin Research 4, no. 1 (February 1, 2001): 30–40. http://dx.doi.org/10.1375/twin.4.1.30.

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AbstractPrevious genetic analyses of psychosis proneness have been limited by their small sample size. For the purposes of large-scale screening, a 12-item questionnaire was developed through a two-stage process of reduction from the full Chapman and Chapman scales. 3685 individuals (including 1438 complete twin pairs) aged 18–25 years and enrolled in the volunteer Australian Twin Registry returned a mail questionnaire which included this psychosis proneness scale and the Eysenck Personality Questionnaire. Despite the brevity of the questionnaire, item and factor analysis identified four unambiguous and essentially uncorrelated scales. There were (1) Perceptual Aberration – Magical Ideation; (2) Hypomania – Impulsivity/Nonconformity; (3) Social Anhedonia and (4) Physical Anhedonia. Model-fitting analyses showed additive genetic and specific environmental factors were sufficient for three of the four scales, with the Social Anhedonia scale requiring also a parameter for genetic dominance. There was no evidence for the previously hypothesised sex differences in the genetic determination of psychosis-proneness. The potential value of multivariate genetic analysis to examine the relationship between these four scales and dimensions of personality is discussed. The growing body of longitudinal evidence on psychosis-proneness suggests the value of incorporating this brief measure into developmental twin studies.
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Germine, L. T., and C. I. Hooker. "Face emotion recognition is related to individual differences in psychosis-proneness." Psychological Medicine 41, no. 5 (September 2, 2010): 937–47. http://dx.doi.org/10.1017/s0033291710001571.

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BackgroundDeficits in face emotion recognition (FER) in schizophrenia are well documented, and have been proposed as a potential intermediate phenotype for schizophrenia liability. However, research on the relationship between psychosis vulnerability and FER has mixed findings and methodological limitations. Moreover, no study has yet characterized the relationship between FER ability and level of psychosis-proneness. If FER ability varies continuously with psychosis-proneness, this suggests a relationship between FER and polygenic risk factors.MethodWe tested two large internet samples to see whether psychometric psychosis-proneness, as measured by the Schizotypal Personality Questionnaire-Brief (SPQ-B), is related to differences in face emotion identification and discrimination or other face processing abilities.ResultsExperiment 1 (n=2332) showed that psychosis-proneness predicts face emotion identification ability but not face gender identification ability. Experiment 2 (n=1514) demonstrated that psychosis-proneness also predicts performance on face emotion but not face identity discrimination. The tasks in Experiment 2 used identical stimuli and task parameters, differing only in emotion/identity judgment. Notably, the relationships demonstrated in Experiments 1 and 2 persisted even when individuals with the highest psychosis-proneness levels (the putative high-risk group) were excluded from analysis.ConclusionsOur data suggest that FER ability is related to individual differences in psychosis-like characteristics in the normal population, and that these differences cannot be accounted for by differences in face processing and/or visual perception. Our results suggest that FER may provide a useful candidate intermediate phenotype.
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de Castro-Catala, Marta, Neus Barrantes-Vidal, Tamara Sheinbaum, Artal Moreno-Fortuny, Thomas R. Kwapil, and Araceli Rosa. "COMT-by-Sex Interaction Effect on Psychosis Proneness." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/829237.

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Schizotypy phenotypes in the general population share etiopathogenic mechanisms and risk factors with schizophrenia, supporting the notion of psychosis as a continuum ranging from nonclinical to clinical deviance. Catechol-O-methyltransferase (COMT) is a candidate susceptibility gene for schizophrenia that is involved in the regulation of dopamine in the prefrontal cortex. Several recent studies have reported a sex difference in the impact of COMT genotype on psychiatric and cognitive phenotypes and personality traits. The present study investigated the association of COMT Val158Met (rs4680) with psychometric positive and negative schizotypy and psychotic experiences in a sample of 808 nonclinical young adults. The main finding was that sex moderates the association of COMT genotype with the negative dimension of both schizotypy and psychotic experiences. Male subjects carrying the Val allele tended to score higher on the negative dimension of both trait and symptom-like measures. The results from the present study are consistent with recent work suggesting an association between negative schizotypy and diminished prefrontal dopamine availability. They support the idea that a biological differentiation underlies the positive and negative schizotypy dimensions. Additionally, these findings contribute to the growing literature on sex-specific effects of COMT on the predisposition to psychiatric disorders and personality traits.
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Burch, Giles St J., David R. Hemsley, Christos Pavelis, and Philip J. Corr. "Personality, creativity and latent inhibition." European Journal of Personality 20, no. 2 (March 2006): 107–22. http://dx.doi.org/10.1002/per.572.

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The current study set out to investigate the relationship between creativity, multi‐dimensional schizotypy and personality more generally. This was achieved by analysing scores on a range of personality scales and measures of creativity, where it was found that the creativity measures were more closely related to asocial‐schizotypy than positive‐schizotypy. The study also sought to test Eysenck's prediction (1993, 1995) that, given the putative relationship between creativity and psychosis‐proneness, high psychosis‐prone scoring individuals and high creativity scoring individuals would demonstrate the same cognitive style of ‘overinclusiveness’ on latent inhibition. However, the results failed to demonstrate any evidence of a shared ‘widening of the associative horizon’ between high creativity and high psychosis‐prone scorers. The findings are discussed in relation to multi‐dimensional schizotypy. Copyright © 2006 John Wiley & Sons, Ltd.
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Mason, O., C. J. A. Morgan, S. K. Dhiman, A. Patel, N. Parti, A. Patel, and H. V. Curran. "Acute cannabis use causes increased psychotomimetic experiences in individuals prone to psychosis." Psychological Medicine 39, no. 6 (November 19, 2008): 951–56. http://dx.doi.org/10.1017/s0033291708004741.

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BackgroundEpidemiological evidence suggests a link between cannabis use and psychosis. A variety of factors have been proposed to mediate an individual's vulnerability to the harmful effects of the drug, one of which is their psychosis proneness. We hypothesized that highly psychosis-prone individuals would report more marked psychotic experiences under the acute influence of cannabis.MethodA group of cannabis users (n=140) completed the Psychotomimetic States Inventory (PSI) once while acutely intoxicated and again when free of cannabis. A control group (n=144) completed the PSI on two parallel test days. All participants also completed a drug history and the Schizotypal Personality Questionnaire (SPQ). Highly psychosis-prone individuals from both groups were then compared with individuals scoring low on psychosis proneness by taking those in each group scoring above and below the upper and lower quartiles using norms for the SPQ.ResultsSmoking cannabis in a naturalistic setting reliably induced marked increases in psychotomimetic symptoms. Consistent with predictions, highly psychosis-prone individuals experienced enhanced psychotomimetic states following acute cannabis use.ConclusionsThese findings suggest that an individual's response to acute cannabis and their psychosis-proneness scores are related and both may be markers of vulnerability to the harmful effects of this drug.
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Thaker, Gunvant, Marianne Moran M.S., R.N., Helene Adami, and Shawn Cassady. "Psychosis proneness scales in schizophrenia spectrum personality disorders: Familial vs. nonfamilial samples." Psychiatry Research 46, no. 1 (January 1993): 47–57. http://dx.doi.org/10.1016/0165-1781(93)90007-4.

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Grant, P., F. Gabriel, Y. Kuepper, C. Wielpuetz, and J. Hennig. "Psychosis-proneness correlates with expression levels of dopaminergic genes." European Psychiatry 29, no. 5 (June 2014): 304–6. http://dx.doi.org/10.1016/j.eurpsy.2013.12.002.

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AbstractPsychosis-proneness or schizotypy is a personality organisation mirroring individual risk for schizophrenia-development. Believed to be a fully dimensional construct sharing considerable geno- and phenotypal variance with clinical schizophrenia, it has become an increasingly promising tool for basic psychosis-research. Although many studies show genetic commonalities between schizotypy and schizophrenia, changes in regulation of gene expression have never been examined in schizotypy before. We therefore extracted RNA from the blood, a valid surrogate for brain tissue, of a large sample of 67 healthy male volunteers and correlated the activities of all genes relevant for dopaminergic neurotransmission with the positive schizotypy-scale of the O-LIFE. We found significant negative correlations regarding the expression of the genes COMT, MAOB, DRD4, DRD5 and FOS, indicating that increased schizotypy coincides with higher levels of dopaminergic dysregulation on the mRNA-level. Considering the advantages of this method, we suggest that it be applied more often in fundamental psychosis-research.
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Knežević, Goran, Ljiljana B. Lazarević, Danka Purić, Michael Bosnjak, Predrag Teovanović, Boban Petrović, and Goran Opačić. "Does Eysenck's personality model capture psychosis-proneness? A systematic review and meta-analysis." Personality and Individual Differences 143 (June 2019): 155–64. http://dx.doi.org/10.1016/j.paid.2019.02.009.

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Mason, O., G. Claridge, and K. Clark. "Electrodermal relationships with personality measures of psychosis-proneness in psychotic and normal subjects." International Journal of Psychophysiology 27, no. 2 (September 1997): 137–46. http://dx.doi.org/10.1016/s0167-8760(97)00057-3.

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Lee, Stuart, Tim Rancie, Wei Lin Toh, Phaybian Penita, Peter Moseley, and Susan Rossell. "M247. PAST AND ANTICIPATED HUMILIATION MAY CONTRIBUTE TO ANXIETY AND PRONENESS TO PSYCHOSIS EXPERIENCES IN A COMMUNITY SAMPLE." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S230. http://dx.doi.org/10.1093/schbul/sbaa030.559.

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Abstract Background Childhood adversity is a risk factor for psychosis. Bullying, abuse, neglect and family conflict can cause biological (e.g. stress hyper-reactivity) and psychological (e.g. negative beliefs about self and perceived threat from others) changes that may lead to psychopathology in adulthood. Past and anticipated humiliation is associated with proneness to persecutory ideation in non-clinical samples. However, whether this is associated with proneness to other positive psychosis symptoms is unclear. This study measured how humiliation is related to hallucination-like experiences (HLE) and intrusive thinking assessed via the Launay-Slade Hallucination Scale Extended and disorganisation assessed via the Schizotypal Personality Questionnaire-Brief Revised, and if increased anxiety mediates this relationship. Methods This cross-sectional study recruited a community sample of 92 adults (62% female; Mean [SD] age = 27.3 [10.8]) who completed measures of past/anticipated humiliation, risky family environment, family socioeconomic status, state anxiety and proneness to positive psychotic 1 2020 Congress of the Schizophrenia International Research Society symptoms. Serial mediation tested for direct and indirect relationships among study variables. Results Worse past and anticipated humiliation, risky family environments and state anxiety correlated with more severe intrusive thoughts, multisensory HLEs and disorganisation (r range 0.23–0.54). Serial mediation showed that of the historical factors, only past humiliation predicted anticipated humiliation (p < 0.001), which in turn was the only unique predictor of state anxiety (p = 0.004). The relationship then differed for proneness to different positive psychosis symptoms. Only state anxiety was a unique predictor of audio-visual HLEs (p = .03) and intrusive thoughts (p = .01), whereas both past humiliation and anxiety predicted disorganisation and multisensory HLEs (both p < .03). Discussion Anxious anticipation about potential harm in interpersonal interactions, likely caused by cumulative past humiliation, may increase proneness to positive psychosis experiences through increased difficulty controlling negative emotions and the frequency and content of worrying thoughts and memories.
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Meyer, Thomas D., and Martin Hautzinger. "Two-Year Stability of Psychosis Proneness Scales and Their Relations to Personality Disorder Traits." Journal of Personality Assessment 73, no. 3 (December 1999): 472–88. http://dx.doi.org/10.1207/s15327752jpa7303_11.

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Salokangas, R. K. R., P. Dingemans, M. Heinimaa, T. Svirskis, S. Luutonen, J. Hietala, S. Ruhrmann, et al. "Prediction of psychosis in clinical high-risk patients by the Schizotypal Personality Questionnaire. Results of the EPOS project." European Psychiatry 28, no. 8 (October 2013): 469–75. http://dx.doi.org/10.1016/j.eurpsy.2013.01.001.

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AbstractObjectiveSchizotypal features indicate proneness to psychosis in the general population. It is also possible that they increase transition to psychosis (TTP) among clinical high-risk patients (CHR). Our aim was to investigate whether schizotypal features predict TTP in CHR patients.MethodsIn the EPOS (European Prediction of Psychosis Study) project, 245 young help-seeking CHR patients were prospectively followed for 18 months and their TTP was identified. At baseline, subjects were assessed with the Schizotypal Personality Questionnaire (SPQ). Associations between SPQ items and its subscales with the TTP were analysed in Cox regression analysis.ResultsThe SPQ subscales and items describing ideas of reference and lack of close interpersonal relationships were found to correlate significantly with TTP. The co-occurrence of these features doubled the risk of TTP.ConclusionsPresence of ideas of reference and lack of close interpersonal relations increase the risk of full-blown psychosis among CHR patients. This co-occurrence makes the risk of psychosis very high.
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Allé, Mélissa C., Fabrice Berna, and Dorthe Berntsen. "Involuntary Autobiographical Memory and Future Thought Predicting Hallucination Proneness." Clinical Psychological Science 6, no. 6 (August 2, 2018): 891–98. http://dx.doi.org/10.1177/2167702618785618.

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Involuntary (spontaneously arising) autobiographical memories and involuntary future thoughts are common in daily life, but their frequency and emotional intensity vary among individuals. Theories of hallucination in schizophrenia have hypothesized a key role for involuntary memories; however, this idea has been little examined. We report two studies, designed to address the role of involuntary mental events in relation to hallucination proneness. Both studies showed that the self-reported frequency of involuntary memories and future projections was a robust predictor of hallucination proneness, even when controlling for measures of unwanted thoughts and rumination (Study 1) and measures of depression, dissociation, executive functions, imagery abilities, and personality (Study 2). In Study 1, the emotional intensity of involuntary memories and future projections also predicted hallucination proneness. The findings open a new avenue of research addressing the role of involuntary autobiographical memories and future projections in relation to hallucination and psychosis.
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Knezevic, Goran, Danka Savic, Vesna Kutlesic, and Goran Opacic. "Disintegration: A reconceptualization of psychosis proneness as a personality trait separate from the Big Five." Journal of Research in Personality 70 (October 2017): 187–201. http://dx.doi.org/10.1016/j.jrp.2017.06.001.

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Araújo Filho, Gerardo Maria de, Vivianne Pellegrino Rosa, Luís Otávio Sales Ferreira Caboclo, Américo Ceiki Sakamoto, and Elza Márcia Targas Yacubian. "Prevalence of psychiatric disorders in patients with mesial temporal sclerosis." Journal of Epilepsy and Clinical Neurophysiology 13, no. 1 (March 2007): 13–16. http://dx.doi.org/10.1590/s1676-26492007000100004.

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OBJECTIVE: Behavioral changes in patients with epilepsy can range from depression, anxiety to psychosis and personality traits. We evaluated the frequency of psychiatric disorders (PD) in a homogenous series of patients with refractory temporal lobe epilepsy (TLE) related to mesial temporal sclerosis (MTS) aiming at determining the frequency of PD and possible correlations to clinical variables and to laterality of MTS. METHODS: Data from 106 refractory TLE patients were reviewed. Psychiatric evaluation was based on DSM-IV criteria. Statistical analysis was performed through the chi-square (chi²), Student's t test and Fisher's exact test. P value considered significant was < 0.05. RESULTS: PD were found in 65 patients (61.3%). Among them, mood disorders were the most frequent (32 patients; 30%), followed by interictal (15 patients; 14%) and postictal (10 patients; 9.4%) psychosis. Postictal and interictal psychosis were significantly associated with left side MTS (p < 0.05), while PD in general and mood disorders were not associated to any side. CONCLUSION: There was a high prevalence of PD in patients with refractory TLE associated to MTS. The most common were mood and psychotic disorders. Psychosis was significantly associated to left side. These findings are concordant with data in literature, confirming the existence of anatomic alterations, and also a possible left laterality effect in the mesial temporal lobe structures in patients with epileptic psychosis.
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Meyer, Thomas D., and Martin Hautzinger. "Prediction of personality disorder traits by psychosis proneness scales in a German sample of young adults." Journal of Clinical Psychology 58, no. 9 (2002): 1091–101. http://dx.doi.org/10.1002/jclp.10040.

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Blain, Scott D., Rachael G. Grazioplene, Yizhou Ma, and Colin G. DeYoung. "Toward a Neural Model of the Openness-Psychoticism Dimension: Functional Connectivity in the Default and Frontoparietal Control Networks." Schizophrenia Bulletin 46, no. 3 (October 11, 2019): 540–51. http://dx.doi.org/10.1093/schbul/sbz103.

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Abstract Psychosis proneness has been linked to heightened Openness to Experience and to cognitive deficits. Openness and psychotic disorders are associated with the default and frontoparietal networks, and the latter network is also robustly associated with intelligence. We tested the hypothesis that functional connectivity of the default and frontoparietal networks is a neural correlate of the openness-psychoticism dimension. Participants in the Human Connectome Project (N = 1003) completed measures of psychoticism, openness, and intelligence. Resting state functional magnetic resonance imaging was used to identify intrinsic connectivity networks. Structural equation modeling revealed relations among personality, intelligence, and network coherence. Psychoticism, openness, and especially their shared variance were related positively to default network coherence and negatively to frontoparietal coherence. These associations remained after controlling for intelligence. Intelligence was positively related to frontoparietal coherence. Research suggests that psychoticism and openness are linked in part through their association with connectivity in networks involving experiential simulation and cognitive control. We propose a model of psychosis risk that highlights roles of the default and frontoparietal networks. Findings echo research on functional connectivity in psychosis patients, suggesting shared mechanisms across the personality–psychopathology continuum.
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Begemann, Marieke, Lindy-Lou Boyette, Aimo Kwast, and Iris Sommer. "T115. PERSONALITY ACROSS THE PSYCHOSIS CONTINUUM: A FINE-GRAINED PERSPECTIVE." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S274. http://dx.doi.org/10.1093/schbul/sbaa029.675.

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Abstract Background Personality is associated with the etiology, course and outcome of psychosis. Previous research has mainly focused on the global domains within the Five-Factor Model of personality. Moreover, little is known on the personality profile of individuals who report frequent psychosis-like experiences (PE) including auditory hallucinations, but do not fulfill criteria for a Cluster A personality disorder or psychotic disorder. Methods We included 134 individuals with non-clinical PE, 40 patients with a psychotic disorder and 126 healthy controls. Participants completed the Dutch NEO-PI-R. ANOVAs were performed to compare personality profiles across the three groups. Results The domains of Neuroticism, Openness and Conscientiousness showed significant group differences. Together with intermediate levels of Neuroticism, individuals with non-clinical PE on average showed high Openness compared to healthy controls and patients (trend-level). The patient group scored high on Neuroticism and low on Conscientiousness compared to both individuals with non-clinical PE and controls. Furthermore, facet-level analyses showed intermediate levels of Depression and Anxiety (N) in individuals with non-clinical PE, as well as high Fantasy, Aesthetics and Ideas (O) relative to controls. The group with non-clinical PE also displayed similar high Angry Hostility (N) and Feelings (O), along with low Trust (A) and Gregariousness (E), as seen in the patient group. Patients showed high Vulnerability and Self-Conscientiousness (N), and also low Competence and Self-discipline (C) compared to both other groups. Discussion This is the first study to provide an analysis of both domain and facet-level data across the psychosis continuum. Our findings underline the added value of a more fine-grained evaluation of personality. We address how certain facets may be related to general PE proneness, both in non-clinical and clinical individuals alike, while other traits may differentiate individuals with non-clinical PE from patients. Current results encourage intervention strategies targeting coping and social skills for youth at risk for psychosis.
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Medjedovic, Janko. "Should the space of basic personality traits be extended to include the disposition toward psychotic-like experiences?" Psihologija 47, no. 2 (2014): 169–84. http://dx.doi.org/10.2298/psi1402169m.

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Previous research has shown that there is a latent disposition toward psychotic-like experiences in the general population, labeled schizotypy. However, there is a dispute over the conceptual status of schizotypy: does it represent merely psychosis proneness, or is it a broad and general personality trait? If a disposition should be regarded even as a candidate for a personality trait, its scores would probably be distributed normally in the population and it must show irreducibility in regard to the previously discovered personality traits. In this research, these questions are addressed, using the construct of Disintegration as an operationalization of schizotypy. The results show that although some modalities of Disintegration have skewed distributions in the student sample (N=345, 65% female), the global Disintegration scores have a normal distribution. Furthermore, Disintegration modalities constitute a latent component which is distinct from the personality traits that form HEXACO model of basic personality structure. Nevertheless, Disintegration shares some variance with the HEXACO traits, especially with the negative poles of Extraversion and Conscientiousness. The results suggest that a conceptual view of a schizotypy as a personality trait is at least plausible and they can be used as guidelines for future empirical studies of this problem.
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Medjedovic, Janko, Daliborka Kujacic, and Goran Knezevic. "Personality-related determinants of criminal recidivism." Psihologija 45, no. 3 (2012): 277–94. http://dx.doi.org/10.2298/psi1203277m.

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The goal of this study was to explore personality-related determinants of recidivism, with recidivism being defined as a) the number of lawful sentences a person had (criminal legal recidivism), and b) the number of prison sentences pronounced (penal recidivism). The study was carried out in two independent samples: a) convicts from the Correctional Institution of Belgrade - Penitentiary of Padinska Skela (N=113), and b) convicts from the Special Prison Hospital in Belgrade (N =112). The variables of the Five-Factor Model of Personality (Neuroticism, Extraversion, Openness, Agreeableness and Conscientiousness) were measured, together with two additional basic personality traits: Disintegration (a broad dimension of psychosis-proneness), and Amorality (three factors representing a disposition to amoral forms of behavior). In addition, psychopathy (Manipulative and Antisocial tendencies) - a psychological entity expected to most successfully predict criminal recidivism - was measured as well. The efficiency of prediction of the two criteria of recidivism was assessed separately in each of those two samples. The results revealed differences in the orchestration of predictors depending on the kind of recidivism as the criterion and the severity of offense. The most important predictors of both forms of recidivism in the sample of convicts with lower intensity of criminal behavior were psychopathic traits. However, in the sample of convicts with higher intensity and variety of criminal behavior, the most important predictors of the number of sentences were Antisociality and Amorality Induced by Frustration, while the most important predictors of the number of prison sanctions were Amorality Induced by Brutality and Disintegration.
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Giakoumaki, Stella G. "Cognitive and Prepulse Inhibition Deficits in Psychometrically High Schizotypal Subjects in the General Population: Relevance to Schizophrenia Research." Journal of the International Neuropsychological Society 18, no. 4 (May 22, 2012): 643–56. http://dx.doi.org/10.1017/s135561771200029x.

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AbstractSchizophrenia and schizotypal personality disorder share common clinical profiles, neurobiological and genetic substrates along with Prepulse Inhibition and cognitive deficits; among those, executive, attention, and memory dysfunctions are more consistent. Schizotypy is considered to be a non-specific “psychosis-proneness,” and understanding the relationship between schizotypal traits and cognitive function in the general population is a promising approach for endophenotypic research in schizophrenia spectrum disorders. In this review, findings for executive function, attention, memory, and Prepulse Inhibition impairments in psychometrically defined schizotypal subjects have been summarized and compared to schizophrenia patients and their unaffected first-degree relatives. Cognitive flexibility, sustained attention, working memory, and Prepulse Inhibition impairments were consistently reported in high schizotypal subjects in accordance to schizophrenia patients. Genetic studies assessing the effects of various candidate gene polymorphisms in schizotypal traits and cognitive function are promising, further supporting a polygenic mode of inheritance. The implications of the findings, methodological issues, and suggestions for future research are discussed. (JINS, 2012, 18, 1–14)
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Milenkovic, Sanja, Goran Belojevic, and Radojka Kocijancic. "Left-handedness and health." Srpski arhiv za celokupno lekarstvo 138, no. 5-6 (2010): 387–90. http://dx.doi.org/10.2298/sarh1006387m.

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Hand dominance is defined as a proneness to use one hand rather than another in performing the majority of activities and this is the most obvious example of cerebral lateralization and an exclusive human characteristic. Left-handed people comprise 6-14% of the total population, while in Serbia, this percentage is 5-10%, moving from undeveloped to developed environments, where a socio-cultural pressure is less present. There is no agreement between investigators who in fact may be considered a left-handed person, about the percentage of left-handers in the population and about the etiology of left-handedness. In the scientific literature left-handedness has been related to health disorders (spine deformities, immunological disorders, migraine, neurosis, depressive psychosis, schizophrenia, insomnia, homosexuality, diabetes mellitus, arterial hypertension, sleep apnea, enuresis nocturna and Down Syndrome), developmental disorders (autism, dislexia and sttutering) and traumatism. The most reliable scientific evidences have been published about the relationship between left-handedness and spinal deformities in school children in puberty and with traumatism in general population. The controversy of other results in up-to-now investigations of health aspects of left-handedness may partly be explained by a scientific disagreement whether writing with the left hand is a sufficient criterium for left-handedness, or is it necessary to investigate other parameters for laterality assessment. Explanation of health aspects of left-handedness is dominantly based on Geschwind-Galaburda model about 'anomalous' cerebral domination, as a consequence of hormonal disbalance. .
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Mushtaq, A., B. Fatima, A. A. Fatema, H. Syed, and H. Sohail. "Interpersonal sensitivity in the at-risk mental state for psychosis in Karachi, Pakistan." European Psychiatry 41, S1 (April 2017): S563. http://dx.doi.org/10.1016/j.eurpsy.2017.01.819.

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IntroductionInterpersonal sensitivity can be explained as a personality trait in which there is an excessive and expanded awareness of the behavior and emotions of others. Individuals having high interpersonal sensitivity are sensitive to interpersonal relationships and self-deficiencies in comparison to others. Studies report that high interpersonal sensitivity can cause low self-esteem and feelings of insecurity.ObjectivesThe objective of this study was to examine the level of interpersonal sensitivity in individuals with an at-risk mental state (ARMS) for psychosis compared to the individuals not at risk for psychosis.MethodsA total sample of 50 individuals was recruited from Bahria University, Karwan-e-Hayat and Karachi Psychiatric Hospital: 25 with ARMS for psychosis and 25 participants who were not ARMS, according to scores on Schizophrenia Proneness Inventory-Adult (SPI-A). All of the participants then responded to self-report questionnaire on Interpersonal Sensitivity Measure.ResultsResults showed that the group with ARMS had a significantly higher interpersonal sensitivity on average (112.5) as compared to healthy individuals (91.8). Results show significant difference in both of the groups (t = –5.049; P < .0001) indicating that interpersonal sensitivity in people with ARMS was relatively high compared to those who were not at risk.ConclusionThis study suggests that being ‘hypersensitive’ to interpersonal interactions is a psychological feature of the potentially prodromal phase of psychosis. Addressing difficulties in interpersonal relationships and offering early psychotherapeutic interventions can be beneficial, not only in averting serious illness, but preventing loss to individual and national productivity.Disclosure of interestThe authors have not supplied their declaration of competing interest.
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Airey, Nicola D., Richard Hammersley, and Marie Reid. "Schizotypy but not Cannabis Use Modestly Predicts Psychotogenic Experiences: A Cross-Sectional Study Using the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE)." Journal of Addiction 2020 (October 14, 2020): 1–7. http://dx.doi.org/10.1155/2020/5961275.

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Objective. Cannabis use predicts psychosis in longitudinal studies, but it is difficult to infer causation. Some precursor variables predict both, including childhood trauma and adversity. Additionally, some of the desired effects of cannabis use resemble the symptoms of psychosis. It would be preferable to assess psychotomimetic or “unusual” experiences that include psychotic symptoms but without assuming pathology. Finally, it is possible that similar people are prone to psychosis and drawn to cannabis use, perhaps, because they are sensitive or attracted to unusual experiences. Schizotypy provides a trait measure of proneness to unusual experiences. The study aimed to examine cross-sectionally relationships between cannabis use, schizotypy, and unusual experiences whilst controlling for current trauma symptoms. Method. A volunteer online sample (n = 129, 64% women, predominantly students) who had used cannabis at least once was recruited. People who reported active effects of past trauma were excluded with a brief primary care posttraumatic stress disorder screen. Participants completed the Oxford-Liverpool Inventory of Feelings and Experience, the Cognitive Failures Questionnaire, and measures of substance use and sociodemographics. Results. The majority of respondents recounted unusual experiences after cannabis use, and many of these might have been considered symptoms of psychosis if they had received medical attention. In regression analysis, the only predictor of the unusual experiences scale of O-LIFE was schizotypy (measured by the remaining subscales; 4% of variance). There were no correlations between cannabis use frequency and schizotypy or unusual experiences. Conclusions. These findings suggest that, after controlling for schizotypy and excluding people who are actively experiencing the effects of past trauma, frequency of cannabis use does not predict unusual experiences. However, individuals with schizotypal personality traits may have more unusual experiences when using cannabis.
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Corr, Philip J., Allison Tynan, and Veena Kumari. "Personality Correlates of Prepulse Inhibition of the Startle Reflex at Three Lead Intervals." Journal of Psychophysiology 16, no. 2 (January 2002): 82–91. http://dx.doi.org/10.1027//0269-8803.16.2.82.

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Abstract The acoustic startle reflex (ASR) is modulated by a number of experimental factors, the most important of which in the field of psychopathology is weak prestimulation: The ASR is reliably reduced if preceded briefly by a weaker stimulus (i. e., the prepulse), an effect known as prepulse inhibition (PPI). PPI is thought to reflect centrally-mediated sensorimotor gating of stimuli, preventing cognitive overload and behavioural confusion. PPI is impaired in a variety of psychiatric disorders, notably schizophrenia, as well as in individuals who score high on psychometric measures of psychosis proneness. Two experiments examined the association of personality (trait emotionality) and PPI at three prepulse-to-pulse intervals (30, 60 and 120 ms). Consistent with previous reports, findings from both experiments showed highly significant PPI (defined as percentage reduction in the amplitude of the ASR), which increased with prepulse-to-pulse interval (30 < 60 < 120 ms). A novel finding was that, in both experiments 1 (N = 36) and 2 (N = 63), the trait of neuroticism was negatively correlated with PPI; in addition, a measure of positive incentive motivation (i. e., Behavioural Activation System, Drive subscale; BAS-Drive) was also negatively correlated with PPI. These trait emotionality associations were independent of gender. Possible causal explanations of these personality associations are outlined. It is concluded that, in order to clarify the aetiological role of sensorimotor gating in psychopathological conditions (e. g., schizophrenia, often entailing emotional activation), trait emotionality variance should be routinely examined in future PPI studies.
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Senín-Calderón, Cristina, Salvador Perona-Garcelán, Sandra Fuentes-Márquez, and Juan F. Rodríguez-Testal. "A Mediation Model for Ideas of Reference." Psychological Reports 120, no. 3 (February 20, 2017): 443–59. http://dx.doi.org/10.1177/0033294117693593.

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Ideas of reference are common in human beings, but they are frequent in certain psychopathological disorders, mainly those concerning the psychotic spectrum. The purpose of this study was to attempt to construct a model predicting the appearance of ideas of reference and to test the relationship of personality (based on the Gray model), emotional, and self-consciousness variables. Five-hundred and seventy-four participants (287 patients with several different psychopathological diagnoses) filled in the Referential Thinking Scale (REF), the GHQ-28, the Self-Consciousness Scale (SCS-R), and the SPSRQ Scale. The resulting model found full mediation of sensitivity to punishment, sensitivity to reward, depression, and public self-consciousness between anxiety and ideas of reference, regardless of the group they were in (patients vs. nonpatients). This result, based on the appearance of anxiety symptomatology, explains 43% of the variance in scores, showing the presence of ideas of reference and therefore enables prediction of a set of vulnerabilities (established with self-reports) which could lead to a psychological state of high general pathological risk and proneness to psychosis in particular.
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Lenzenweger, Mark F., John F. Clarkin, Otto F. Kernberg, and Pamela A. Foelsch. "The Inventory of Personality Organization: Psychometric properties, factorial composition, and criterion relations with affect, aggressive dyscontrol, psychosis proneness, and self-domains in a nonclinical sample." Psychological Assessment 13, no. 4 (December 2001): 577–91. http://dx.doi.org/10.1037/1040-3590.13.4.577.

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Meisner, Maria W., Mark F. Lenzenweger, Bo Bach, Martin Vestergaard, Lea S. Petersen, Ulrik H. Haahr, Mickey Kongerslev, and Erik Simonsen. "Exploring Identity Disturbance and Psychotic Spectrum Symptoms as Predictors of Borderline and Schizotypal Personality Disorders." Psychopathology 54, no. 4 (2021): 193–202. http://dx.doi.org/10.1159/000516209.

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<b><i>Introduction:</i></b> Borderline personality disorder (BPD) and schizotypal personality disorder (SPD) were introduced in DSM-III and retained in DSM-5 Section II. They often co-occur and some aspects of the clinical differentiation between the 2 diagnoses remain unclear (e.g., psychotic-like features and identity disturbance). <b><i>Methods:</i></b> The present study explored if self-reported identity disturbance and psychosis proneness could discriminate between the BPD and SPD DSM-5 diagnoses. All patients were interviewed with the Schedules for Clinical Assessment in Neuropsychiatry and the Structured Clinical Interview for DSM-5 Personality Disorders, and administered the Inventory of Personality Organization, Self-Concept and Identity Measure, Schizotypal Personality Questionnaire, Perceptual Aberration Scale, and the Magical Ideation Scale. <b><i>Results:</i></b> A total of 105 patients were initially assessed, 26 were excluded, and the final sample (<i>N =</i> 79) was composed of 34 BPD patients, 25 SPD patients, and 20 patients with co-occurring SPD and BPD. The BPD group (<i>n</i> = 34) was first compared with the pure SPD group (<i>n</i> = 25), and secondly with the total group of patients diagnosed with SPD (<i>n</i> = 25 + 20). Logistic regression analyses indicated that primitive defenses and disorganization best differentiated the BPD and the pure SPD group, while primitive defenses and interpersonal factor along with perceptual aberrations best differentiated the BPD and the total SPD group. <b><i>Conclusion:</i></b> Identity disturbance did not predict the diagnostic groups, but BPD patients were characterized by primitive defenses, which are closely related to identity disturbance. Pure SPD was characterized by oddness/eccentricity, while the lack of specificity for cognitive-perceptual symptoms suggests that the positive symptoms do not differentiate BPD from SPD.
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Modinos, G., A. Mechelli, J. Ormel, N. A. Groenewold, A. Aleman, and P. K. McGuire. "Schizotypy and brain structure: a voxel-based morphometry study." Psychological Medicine 40, no. 9 (November 17, 2009): 1423–31. http://dx.doi.org/10.1017/s0033291709991875.

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BackgroundSchizotypy is conceptualized as a subclinical manifestation of the same underlying biological factors that give rise to schizophrenia and other schizophrenia spectrum disorders. Individuals with psychometric schizotypy (PS) experience subthreshold psychotic signs and can be psychometrically identified among the general population. Previous research using magnetic resonance imaging (MRI) has shown gray-matter volume (GMV) abnormalities in chronic schizophrenia, in subjects with an at-risk mental state (ARMS) and in individuals with schizotypal personality disorder (SPD). However, to date, no studies have investigated the neuroanatomical correlates of PS.MethodSix hundred first- and second-year university students completed the Community Assessment of Psychic Experiences (CAPE), a self-report instrument on psychosis proneness measuring attenuated positive psychotic experiences. A total of 38 subjects with high and low PS were identified and subsequently scanned with MRI. Voxel-based morphometry (VBM) was applied to examine GMV differences between subjects with high and low positive PS.ResultsSubjects with high positive PS showed larger global volumes compared to subjects with low PS, and larger regional volumes in the medial posterior cingulate cortex (PCC) and the precuneus. There were no regions where GMV was greater in low than in high positive PS subjects.ConclusionsThese regions, the PCC and precuneus, have also been sites of volumetric differences in MRI studies of ARMS subjects and schizophrenia, suggesting that psychotic or psychotic-like experiences may have common neuroanatomical correlates across schizophrenia spectrum disorders.
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Sándor, Rózsa, Vincze Gábor, Török Imre András, Hupuczi Ernő, Hargitai Rita, Martin László, Hartung István, Tiringer István, Simon Mária, and Kállai János. "A Mágikus Fogalomképzés Skála hazai változatának kialakítása." Mentálhigiéné és Pszichoszomatika 21, no. 4 (January 9, 2021): 401–41. http://dx.doi.org/10.1556/0406.21.2020.018.

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Háttér: A pszichózisra való sérülékenység feltárása és a korai intervenció a klinikai gyakorlat és a kutatások fontos részét képezik. A Mágikus Fogalomképzés Skála az egyik leggyakrabban alkalmazott önjellemző kérdőív, amelyet a pszichózisra való hajlam feltárására dolgoztak ki. Meglepő azonban, hogy a Mágikus Fogalomképzés Skála pszicho­ metriai jellemzőit klinikai mintán szinte alig vizsgálták. Célkitűzés: A tanulmány fő célja a Mágikus Fogalomképzés Skála faktorszerkezetének feltárása nagy elemszámú egyetemi hallgatói mintán (n = 1730) és pszichiátriai betegek (n = 319) körében. Módszerek: A kérdőív faktorszerkezetét megerősítő (egydimenziós, többdimenziós szerkezet, bifaktoros elrendezés) és feltáró faktorelemzések, valamint parallel­elemzések segítségével vizsgáltuk. A skálák megbízhatóságát a hagyományos módszerek mellett (pl. Cronbach­α) modellalapú megbízhatósági becslésekkel (hierarchikus ómega) is jellemeztük. A faktorszerkezet elemzését követően a valószínűségi tesztelméleti alapokon nyugvó Tétel­válasz elmélet (Item Response Theory, IRT) segítségével az item­paraméterek becslését (nehézség és diszkrimináció) és az eltérő tételműködést is megvizsgáltuk, majd egy rövid, 15 tételes változatot alakítottunk ki, amelynek a kritériumvaliditását más mérőeszközök felhaszná- lásával teszteltük (pl. Szkizotípia Személyiség Kérdőív rövid változat; Davis­féle Empátia Kérdőív). Eredmények: A parallel­elemzés a hallgatói mintán 3 faktort, míg a klinikai mintán 2 dimenziót valószínűsített. Mindkét minta esetében a negatív tételek önálló dimen ziót alkottak, amit járulékos faktornak tekintetve a későbbiekben nem elemeztünk. A megerősítő faktorelemzés a normatív hallgatói mintán a bifaktoros struktúrát támasztotta alá, ahol az általános faktor mellett két speciális dimenzió jelent meg: paranormális hiedelmek és mágikus okság/spiritualitás (RMSEA = 0,052; CFI = 0,993; TLI = 0,990). A klinikai mintán az egydimenziós szerkezet adta a legjobb illeszkedési mutatókat (RMSEA = 0,032; CFI = 0,970; TLI = 0,965). A 15 tételre rövidített skála jó pszichometriai jellemzőkkel rendelkezett, bár az IRT elemzés rávilágított arra, hogy néhány tétel eltérő jelentést hordoz a nemek (nők vs. férfiak) vagy a vizsgálati minta típusa (normatív vs. klinikai) szerinti összevetéskor. Következtetések: Eredményeink megerősítik, hogy a mágikus fogalomalkotás a klinikai mintán egydimenziós modellel ragadható meg leginkább, ezzel szemben a normatív hallgatói mintán már inkább egy bifaktoros struktúra valószínűsíthető, amelynek két speciális dimenziója az adaptív (mágikus okság/spiritulaitás) és maladaptív (paranormális hiedelmek) sajátosságok mentén különül el.Background: Study of vulnerability to psychosis and early intervention is an area of great clinical impact and research. The Magical Ideation Scale (MIS) is among the most widely used instruments for the assessment of psychosis proneness. However, there has been little research on the psychometric properties of the MIS in clinical sample. Aims: The main goal of the present work was to study the dimensional structure underlying the MIS in a large sample of students (n = 1.730) and clinical subjects (n = 319). Methods: The structures of the MIS were examined by confirmatory (e.g., single-factor model, model with second-order factor, bifactor model) and exploratory factor analysis and parallel-analysis. The internal consistencies were calculated not only in the conventional way (e.g. Cronbach’s α) but also in the controlling of the general factor (hierarchical omega, explained common variance). After initial testing, we used Item Response Theory (IRT) to shorten and further refine the instrument, and criterion validity was evaluated by other questionnaires (e.g. Schizotypy Personality Questionnaire – Brief Revised; Interpersonal Reactivity Index). Results: To determine the number of factors that can be applied, parallel-analysis provided a good estimation of the three dimensional structure of MIS in student sample and two dimensions in clinical subjects. However, the reversed worded items caused a method factor that does not appear to be substantively meaningful. Confirmatory factor analysis identified a bifactor solution (general scale and two specific scales: paranormal beliefs and magical reasoning/spirituality) for the MIS in student sample (RMSEA = 0.052, CFI = 0.993, TLI = 0.990), and a unidimensional factor structure in clinical sample (RMSEA = 0.032, CFI = 0.970, TLI = 0.965). The shortened 15-item version of the MIS has good psychometric properties, but few of the items displayed DIF across gender or type of sample (normative or clinical). Conclusions: Our results confirm that magical ideation can be considered as a single latent psychological variable on clinical sample, and a bifactorial structure in normative sample where the adaptive (magical reasoning/spirituality) and maladaptive (paranormal beliefs) functions separated.
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Oehrn, Carina R., Jana Schönenkorb, Lars Timmermann, Igor Nenadić, Immo Weber, and Phillip Grant. "Schizotypy in Parkinson’s disease predicts dopamine-associated psychosis." Scientific Reports 11, no. 1 (January 12, 2021). http://dx.doi.org/10.1038/s41598-020-80765-5.

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AbstractPsychosis is the most common neuropsychiatric side-effect of dopaminergic therapy in Parkinson’s disease (PD). It is still unknown which factors determine individual proneness to psychotic symptoms. Schizotypy is a multifaceted personality trait related to psychosis-proneness and dopaminergic neurotransmission in healthy subjects. We investigated whether (1) PD patients exhibit lower schizotypy than controls and (2) dopamine-related neuropsychiatric side-effects can be predicted by higher schizotypy. In this cross-sectional study, we used the Oxford-Liverpool Inventory of Feelings and Experiences in 56 PD patients (12 women, mean ± sd age: 61 ± 11 years) receiving their usual dopaminergic medication and 32 age-matched healthy controls (n = 32; 18 women, mean ± sd age: 57 ± 6 years). We further compared schizotypy scores of patients with (n = 18, 32.1%) and without previously experienced psychosis. We found that patients exhibited lower schizotypy than controls. Further, patients with a history of psychosis exhibited higher schizotypy than patients without these symptoms. Using an information theoretic measure and a machine learning approach, we show that schizotypy yields the greatest predictive value for dopamine-associated hallucinations compared to other patient characteristics and disease related factors. Our results indicate an overlap between neural networks associated with schizotypy and the pathophysiology of PD and a relationship between schizotypy and psychotic side-effects of dopaminergic medication.
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Begemann, Marieke J. H., Lindy-Lou Boyette, Aimo K. Kwast, and Iris E. C. Sommer. "Personality Across the Psychosis Continuum: A Fine-Grained Perspective." Schizophrenia Bulletin Open 1, no. 1 (January 1, 2020). http://dx.doi.org/10.1093/schizbullopen/sgaa064.

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Abstract Background Personality is associated with the etiology, course, and outcome of psychosis. Yet, more specific knowledge on this association, beyond the global domains of the Five-Factor Model, is scarce. One way to investigate this is to study the personality profile of individuals having frequent psychosis-like experiences (PE), but without clinical psychosis or Cluster A personality disorder and compare them to patients with such symptoms. Methods We included 134 individuals with nonclinical PE, 40 psychotic disorder patients, and 126 healthy controls. Participants completed the NEO-PI-R. Domain and facet-level data were compared across groups. Result As expected, group differences were significant for Neuroticism, Openness, and Conscientiousness. Facet-level analyses showed intermediate levels of Depression and Anxiety (N) in individuals with nonclinical PE, together with high Fantasy, Aesthetics and Ideas (O) compared to controls. Notably, they displayed high Angry Hostility (N) and Feelings (O), along with low Trust (A) and Gregariousness (E). Patients showed high Vulnerability and Self-Consciousness (N), and low Competence and Self-discipline (C), while both nonclinical groups showed similar levels. Conclusions This is the first study to analyze both domain and facet-level data across the psychosis continuum. Our findings show how the facets Hostility and Feelings, low Trust and Gregariousness may be related to general PE proneness, both in nonclinical and clinical individuals alike, while Vulnerability and Self-Consciousness, low Competence, and low Self-discipline may differentiate patients from individuals with nonclinical PE. Current results encourage intervention strategies targeting coping and social skills for youth at risk for psychosis.
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Mętel, Dagmara, Andrzej Cechnicki, Aleksandra Arciszewska-Leszczuk, Renata Pionke-Ubych, Martyna Krężołek, Piotr Błądziński, Dorota Frydecka, and Łukasz Gawęda. "Cognitive and personality predictors of trait resilience in young people with psychosis proneness: an exploratory study." Psychosis, July 5, 2021, 1–12. http://dx.doi.org/10.1080/17522439.2021.1945664.

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