Dissertations / Theses on the topic 'Psychiatric illness'
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1
Corrigan, F. M. "Trace elements and psychiatric illness." Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.592272.
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Developments in analytical techniques have allowed study of the concentrations of more than thirty elements in biological tissues. These methods have been applied to blood and brain tissues from patients with a wide range of psychiatric illness. Increases in blood vanadium concentrations in affective illness are discussed in relation to possible disturbance of noradrenaline metabolism. It is suggested that high vanadium levels may reflect high circulatory levels of noradrenaline but direct evidence of such a link has not yet been obtained. Discussions of elements in dementia centres mainly on aluminium and zinc: the possibility of low zinc concentrations being relevant becomes more likely as evidence accumulates for the role of zinc in hippocampal function. Glutamatergic transmission is likely to be crucial in this context and evidence is presented for an association between glutamate and the rare earth elements cerium and lanthanum in caudate nucleus of schizophrenics. Whether these will prove to have a fucntional role in hippocampus remains to be seen, but possible implications for modulation of striatal dopaminergic function, via glutamatergic corticostriatal tracts, are discussed. Reduction of caesium may be important through altered GABAergic transmission and reduction of indium may reflect changes in dopaminergic neuronal activity. It is considered that this work on human tissue is giving indications of which elements need to be studied in laboratory experiments to elucidate their role in neuronal transmission and, therefore, in psychiatric illness.
2
Knight, Helen Miranda. "Candidate gene studies in psychiatric illness." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/6508.
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Schizophrenia, bipolar disorder and major depression are common, heritable neuropsychiatric conditions and yet the source of the inherited risk remains largely unknown. This thesis focuses on two complementary strategies for identifying and characterising the genetic component of these illnesses: homozygosity mapping in consanguineous pedigrees, and genetic and neurobiological investigations of candidate genes identified by the analysis of structural chromosomal abnormalities carried by patients with psychiatric diagnoses. In a family of a cousin marriage, five of six offspring presented with a rare combination of schizophrenia, sensori-neural hearing impairment and epilepsy. Two loci were located on chromosomes 22q13 and 2p24-25 where a series of markers were homozygous by descent (HBD). Five further HBD loci were identified in a second, related family where four of five offspring had hearing loss. However, there was no overlap of the HBD intervals in the two families, and sequencing coding regions of candidate genes failed to identify causative mutations. A second study investigated the candidate gene ABCA13 identified at a breakpoint region on chromosome 7 in a patient with schizophrenia who carried a complex chromosomal rearrangement. Re-sequencing exons encoding the highly conserved functional domains identified eight potentially pathogenic, rare coding variants. Case control association studies involving cohorts of schizophrenia, bipolar disorder and major depression revealed significant associations of these variants with all three clinical phenotypes, and follow-up in relatives displayed familial inheritance patterns. Disruption of ABCA13, expressed in human hippocampus and frontal cortex, implicates aberrant lipid biology as a pathological pathway in mental illness. A third study focused on GRIK4, a candidate gene previously reported disrupted in a patient with schizophrenia who carried a chromosome abnormality. A deletion in the 3’UTR of GRIK4, encoding the kainate receptor subunit KA1, was identified as a protective factor for bipolar disorder. Using post mortem human brain tissue from control subjects, KA1 protein expression patterns were characterized in the hippocampal formation, amygdala, frontal cortex and cerebellum. KA1 expression was found significantly increased in subjects with the protective allele, supporting the hypothesis that reduced glutamatergic neurotransmission is a risk factor in major psychiatric illnesses. Together, these novel discoveries define aspects of the genetic contribution to mental illness, implicate specific dysfunctional processes and suggest new directions for research in the quest to find rationally based treatments and preventative strategies for some of the most common and disabling psychiatric disorders.
3
Al-Mutawa, Marwan S. "Psychiatric abuse and the concept of mental illness." Thesis, Swansea University, 1989. https://cronfa.swan.ac.uk/Record/cronfa42877.
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This thesis presents a critical analysis of the limitation and weakness of the concept of mental illness and proposes the Reactive Functional Disorder (RFD) approach as an alternative moral perspective on mental illness. Chapter one highlights, through an analysis of the problems of psychiatric treatment in Kuwait, the vulnerability of the concept of mental illness to abuse. In Chapter two, it is argued that the current definitional systems used in psychiatry have contributed to the vulnerability of the concept of mental illness to abuse by employing definitions which are terminologically, clinically, and morally weak. In Chapter three, the RFD approach is presented in the hope that this account might provide a deeper understanding of the moral and conceptual implications of the concept of mental illness. Chapter four provides an analysis of some of the writings of Thomas Szasz, the controversial American psychiatrist, who argues consistently that mental illness is a myth and psychiatry is unlike other well-established medical disciplines. It is argued that Dr. Szasz, in reality, is less against psychiatry than against psychiatric coercion and involuntary hospitalisation.
4
Brady, Ann Marie Brigid. "Chronic illness in childhood and adolescence : a longitudinal exploration of co-occurring mental illness." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/31703.
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Chronic health problems are hypothesised to be a risk factor to child and adolescent mental health, due the consistent and continuing stress these health problems pose to normative patterns of development. However, this theory remains to be substantiated by empirical research. Moreover, a systematic review conducted as part of this research indicated that the empirical body is not one on which the validity of this theory can be adequately tested. The major question posed is whether the lack of high quality epidemiological data in the field is obscuring a true psychiatric risk associated with chronic illness in childhood and adolescence, or whether, in contrast, the theory of chronic health problems as a particular risk factor to child and adolescent mental health, is based on false premises. In order to provide a stronger insight into the association of chronic health problems to mental ill-health across the late childhood and adolescent period, this study used data from a large, representative British sample (the Avon Longitudinal Study of Parents and Children (ALSPAC)) and sensitive measures of mental health outcomes. Mediating factors in these associations were also identified, and a model of the association of chronic health problems to poor mental health outcomes in early adolescence was developed. In order to ensure that all findings were applicable across chronic health conditions, outcomes over this period for children with chronic illness more generally were compared to outcomes for children with asthma diagnoses. Children with chronic health problems presented with a disproportionate rate of psychiatric illness at 10 years, and these chronic health problems continued to be associated with poor mental health outcomes across the early to mid-adolescent period. The outcomes at 10 and 13 years were suggested to be mediated by factors non-specific to any diagnosis, specifically peer victimisation and health-related school absenteeism. Limitations to external validity in the research, and implications for public health and future research are discussed.
5
Murphy, Laura Louise. "Mitochondrial trafficking in a mouse model of psychiatric illness." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28882.
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Disrupted in schizophrenia 1 (DISC1), located on chromosome 1, was first identified due to its disruption by a chromosomal translocation, t(1;11)(q42;q14). This translocation co-segregates with psychiatric illness in the Scottish family within which it was discovered. DISC1 is a component of the mitochondrial trafficking machinery and regulates trafficking of mitochondria in neurons, possibly implicating defective mitochondrial trafficking as a contributory factor in psychiatric illness. The product of another candidate gene for psychiatric illness, Glycogen synthase kinase 3β (GSK3β), is known to interact directly with DISC1 and has also been reported to be involved in mitochondrial trafficking. The interaction of these proteins has not been investigated in this process. The work in this thesis centres around a novel mouse model of the t(1:11) translocation. I use time-lapse imaging of live cells to show that hippocampal neurons cultured from this mouse model exhibit altered axonal mitochondrial trafficking, including reduced mitochondrial pausing. I also demonstrate that the DISC1 interactor GSK3β is a component of the mitochondrial trafficking machinery and investigate effects of the t(1:11) event upon this multi-protein complex. Finally, I demonstrate altered mitochondrial motility responses to overexpression of GSK3β in mutant neurons. Defective mitochondrial trafficking, particularly reduced pausing, could result in an altered distribution of mitochondria within neurons, leading to an impaired ability to respond to cellular conditions, such as the requirement to power synaptic vesicle release or the ion pumps that restore membrane potential following action potential generation. This could ultimately affect neuron viability, leading to brain dysfunction. My data therefore support a proposed disease mechanism whereby defective mitochondrial trafficking contributes to susceptibility to psychiatric illness in carriers of the t(1:11) translocation, and may be relevant to psychiatric illness in general.
6
Mdleleni, Thembeka N. "Cultural construction of psychiatric illness : a case of amafufunyane." Master's thesis, University of Cape Town, 1990. http://hdl.handle.net/11427/13855.
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Bibliography: leaves 96-103.The purpose of this study was to explore definitions of an illness condition amafunyane and the subsequent help-seeking behaviour amongst Black Psychiatric patients who were attending a psychiatric community clinic in Guguletu, a residential area for Blacks in Cape Town). Psychiatrists have always been faced with the problem of having to deal with patients who present with this condition. The concern was to do an exploratory research in this area using the Explanatory Model framework as a method of enquiry in studying the condition of amafunyane. Within the parameters of this model, Black psychiatric patients presenting at the psychiatric clinic, were studied in order to explore the context of illness definitions regarding the condition of amafunyane. Of importance also was to explore the patterns of help-seeking behaviour employed by these patients, and the effect that the psychiatric orientation adopted at the clinic had on such patterns.
7
Williams, William Paul. "Aspects of a psychiatric therapeutic milieu." Thesis, University of East London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361850.
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Bowersox, Nicholas W. "Treatment Attrition and Relapse Readmission in Psychiatric Inpatients: Predictors of Treatment Engagement and Psychiatric Relapse." [Milwaukee, Wis.] : e-Publications@Marquette, 2009. http://epublications.marquette.edu/dissertations_mu/18.
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Favreau, Marie-Diane Lucie. "The pre-shrinking of psychiatry : sociological insights on the psychiatric consumer/survivor movement (1970-1992) /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9935449.
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10
Provencal, Levesque Olivia. "Category Status Conversations in the Psychiatric Context." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41505.
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Background:
Patients with mental illness often experience stigma and marginalization, which affects the quality of their healthcare. In most settings, end of life decisions, including goals of care, must be discussed with all patients upon hospital admission. This includes determining cardiopulmonary resuscitation preferences, in the event of a medical emergency. Despite this requirement, category status conversations do not routinely occur in psychiatry. It is common for psychiatric inpatients, including those at high risk for cardiac or respiratory arrest, to be admitted, cared for, and discharged without their category status known or documented. By default, patients become a ‘full code status’, which mandates life-sustaining interventions, including CPR. Unwanted interventions are often unsuccessful and inappropriate. They might also cause harm through increased pain and suffering or have no medical benefit.
Aim:
To explore how and why category status conversations occur, or do not occur, for patients admitted to psychiatry. Methods:
This was a descriptive qualitative study, with data collected through two semi-structured focus groups. Nine nurses working in psychiatry, representing two campuses of a larger tertiary care academic hospital in Ottawa, Ontario participated. Elo and Kyngäs’s approach to inductive content analysis was used to analyze the verbatim transcripts of the focus group discussions.
Findings:
Findings reveal the shared experiences of nurses initiating and engaging in category status conversations with patients admitted to psychiatry. Four overarching categories were identified: ‘The Psychiatric Culture’, ‘Being a Psychiatric Patient’, ‘Physical Health Status’, and ‘Suggestions and Recommendations’. Participants spoke about important considerations for the advancement of knowledge regarding category status conversations in psychiatry, including the nurse’s role in category status determination, the challenges of implementing a ‘one-size fits all’ approach to category status policies, and the ways in which HCPs perceptions of patients who are receiving care for depression or suicidal ideation influence these conversations in psychiatry.
Conclusion:
Nurses working in psychiatry care for patients with complex medical and psychiatric comorbidities, who are also sometimes older and frail. Category status determination for these patients is complicated and often the documented status is based on clinician presumption rather than consultation with the patient. Although the importance of completing category status conversations with patients admitted to psychiatry is known, they seldomly occur, and there is ambiguity about the nursing role within the psychiatric context. Efforts are needed to improve nurses’ contributions to category status determination for patients admitted to psychiatry, to ensure that patients’ preferences are known and upheld. Further, there are illness-related factors that complicate typical processes used to discuss and identify patient preferences, such as suicidal ideation and minimal family support. These considerations must be accounted for in hospital policy if meaningful practice change is expected.
11
Lau, Bernard W. K. "Psycho-cultural constructs of illness in a Chinese population." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262877.
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White, Peter Denton. "A prospective study of fatigue and psychiatric illness following glandular fever." Thesis, Queen Mary, University of London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294871.
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Young, Merryn. "The prevalence of physical illness in defendants referred for psychiatric observation." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/10749.
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Includes bibliographical references.The rationale of doing thorough medical screening of all psychiatric patients is clear, because there is a relationship between medical illness and mental illness. It remains unresolved which screening tests should be performed routinely in general psychiatric patients even though the prevalence of medical illness is relatively high. Even less is known about the prevalence of medical illnesses in criminal defendants referred for observation, most of whom do not have a serious psychiatric disorder. Special investigations may be necessary in the diagnosis of these medical conditions. Within the context of psychiatry as a whole, the population referred for forensic observation may be subject to more stringent investigation as a legal requirement. However there is little information available on this group regarding the prevalence of medical illnesses and the impact that these have on the psycho-legal assessment. This study will therefore seek to assess the current practice of routine investigations in assessing criminal defendants that have been referred to the forensic observation unit in order to assess whether these findings contribute significantly to the psycho-legal assessment, and to determine the prevalence of medical illness in this population. It is hoped that it will be possible to decide whether there is utility to do routine tests, essentially by coercion, in this group.
14
Bennett, Joanna. "Community psychiatric nurse practice in assessing side effects of antipsychotic drugs." Thesis, University of Hertfordshire, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309696.
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Moran, James E. "Insanity, the asylum and society in nineteenth-century Quebec and Ontario." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0021/NQ27309.pdf.
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Mak, Kin-ming. "Emergency psychiatric attendance in a Hong Kong hospital : a local experience in understanding factors associated with re-attendance /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3688635X.
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Winn, S. "The geography of old age mental disorders in Nottingham." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370533.
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Manktelow, Roger. "Routes to hospital : a sociological analysis of the paths to psychiatric hospitalisation." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254018.
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Moulder, Janelle Katie. "Psychiatric Illness in the Next-of-Kin of Intensive Care Unit Patients." Yale University, 2009. http://ymtdl.med.yale.edu/theses/available/etd-03032009-212643/.
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The prevalence of psychiatric symptoms in next-of-kin (NOK) of intensive care unit (ICU) patients has been reported at higher than 70% when screening is performed using the Hospital Anxiety and Depression Scale (HADS). The primary purpose of this study was to assess the ability of the HADS to predict psychiatric illness, diagnosed with the aide of a validated tool, the Structured Clinical Interview for DSM-IV (SCID). In addition, we asked NOK to rate aspects of the ICU experience to determine possible associations with psychiatric diagnosis. Thirty-four NOK were enrolled in this study from July 2006 to November 2006. Subjects were interviewed to gather demographic information, their perception of the ICU experience, and to administer the SCID and the HADS. At least 6 months later, subjects were contacted by telephone to determine presence of psychiatric morbidity after the ICU experience. Fifty-six percent of all NOK experienced symptoms of either anxiety or depression during the ICU admission and 24% had psychiatric illness. The HADS had 100% sensitivity and 58% specificity when used as a screening tool for psychiatric diagnosis. Those with any SCID diagnosis were more likely to be a spouse (50% vs. 9%, p = 0.013) or a primary caregiver (60% vs. 8%, p = 0.003). Most NOK identified the healthcare team as supportive, though a subgroup of NOK who slept in the ICU reported that they found the healthcare team less supportive. This small study suggests the HADS is able to predict psychiatric illness in NOK of ICU patients. The ability to implement this tool as part of clinical practice to better meet the needs of families in the ICU warrants further investigation.
20
Southern, Annie Roma. "Career, Interrupted?: Psychiatric illness and Women's Career Development in Aotearoa/New Zealand." Thesis, University of Canterbury. Health Sciences Centre, 2010. http://hdl.handle.net/10092/4118.
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This thesis explores the experiences of a group of women in Aotearoa/New Zealand who have been diagnosed with a psychiatric illness, with the aim of gaining some understanding about how they negotiate issues around diagnosis, recovery and resilience-development and employment.
A qualitative methodology was used to encourage the women to relate their vocational and life experiences. Fifteen women, whose ages ranged from 17 to their late 60s, with a range of psychiatric diagnoses, were interviewed across ten months. One woman identified as having Māori ancestry and several identified as lesbian. Each interview, which was semi-structured, was transcribed and then verified by the women, and all data were analysed using thematic content analysis and symbolic interactionist and discourse/narrative analyses. Salient issues provided a focus for later interviews and generated theory.
The thesis is organised according to major themes that were generated from the data: ‘Getting unwell and getting help,’ ‘Getting well’ and ‘Getting back to work.’ Within these broad themes, key ideas emerged around the women’s views on the difference between ‘madness’ and ‘mental illness’, the biological basis for mental distress, the impact of labelling, the importance of having a ‘literacy’ around psychiatric illness that helps foster agency, the importance of workplace accommodations and mentors in vocational settings, and the process of renegotiating vocational identity when one has a psychiatric illness.
Data analysis revealed how participants make ‘sense’ of their psychiatric ill health and recovery/resilience-development experiences, create a vocational self-concept and view themselves as social beings in the current socio-political and cultural context of being New Zealanders. The women’s narratives exhibited negligible explicit gender role identification and the present research uncovered very little explicit data relevant to lesbian and bisexual women’s lives, apart from data on sexual identity disclosure. Rather the women spoke as members of a group that accepted Western diagnoses and used various strategies to reclaim what had been lost and grow new social and vocational roles.
The thesis, therefore, provides a platform for understanding the experiences of women living with psychiatric illness in Aotearoa/New Zealand. It provides new information on service-users’ views of medical models of psychiatric illness and the efficacy of their alliances with mental health professionals. It also provides evidence of the needs women have for gaining and maintaining employment after diagnosis with psychiatric illness.
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LeMay, Carrie C., Jill D. Stinson, Lydia L. Eisenbrandt, Courtney Smith, and Megan Quinn. "Polypharmacy Among Psychiatric Inpatients With Serious Mental Illness in Secure Forensic Care." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/7951.
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Polypharmacy is broadly defined as the administration of more than one medication in a single patient, with the most commonly used definition indicating the concurrent use of five or more medications. Polypharmacy occurs in most clinical settings, particularly inpatient settings and treatment settings for persons with chronic illness and the elderly. Reasons for receiving more than one medication include ineffective treatment with monotherapy, targeting specific but varied symptoms, treating two distinct but co-morbid illnesses, addressing unremitting symptoms, and treating extrapyramidal side effects. Research indicates that each medication added to the patient’s regimen increases the likelihood of an adverse outcome, as well as the risk of adverse drug reactions, drug-to-drug interactions, cumulative toxicity, medication errors, patient non-compliance, patient morbidity, and patient mortality. The current study seeks to investigate the rates of polypharmacy and related characteristics predictive of polypharmacy within a forensic psychiatric setting. A total of 182 patients residing in a secure forensic psychiatric hospital were selected. The sample is predominantly male (80.8%, n=147) and majority Caucasian (55.5%, n=101), African American (40.1%, n=73), and Hispanic (2.2%, n=4), with a mean age of 43.5 (SD=13.2). Participants range from persons with at least one mental health disorder (100%, n=182) to persons with at least one chronic illness (74.5%, n=132). Of those currently taking medications, 99.2% have been prescribed more than one type of medication, with 93.1% of those individuals being prescribed four or more. Polypharmacy was observed in 91% of participants. Of those diagnosed with a mood or psychotic disorder, an average of 3.6 different types of psychotropic medications were prescribed. Co-morbidity of mental illness was predictive of polypharmacy trends, F(1,181)=5.28, p<.05. Additionally, individuals with at least one chronic illness also were subjected to polypharmacy practices, with rates increasing for those with more than one chronic illness. As a measure of onset and severity of symptoms, age at first hospitalization and age of onset of aggressive behaviors were measured, and, interestingly, both measures were predictive of polypharmacy within these patients, F(1, 181)=13.45, p<.01. Results indicate that perceived severity of symptomology, aggression, and complex health problems all contribute to polypharmacy practices among prescribing physicians. The high rates of polypharmacy observed are concerning because of the potential for increased aversive health outcomes. Understanding the predictive factors, rates, and trends of polypharmacy has valuable implications for the future treatment and rehabilitation of individuals residing in a forensic psychiatric setting.
22
Underwood, Sarah. "Genetic analysis of a candidate region for psychiatric illness on chromosome 4p." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/27567.
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I have studied four families that show linkage of psychiatric illness to chromosome 4p. Linkage was first observed in a large family, F22 segregating bipolar and unipolar affective disorders. Subsequently, a smaller family, F59, segregating affective disorders and two families (F50 & F48) segregating schizophrenia, schizoaffective and bipolar disorders confirmed this linkage. Previously, comparison of the two haplotypes inherited with illness in each family allowed prioritisation of two sub-regions for detailed study. Minimal Region 1 (MR1) is defined by overlap of the disease chromosomes from three Celtic families (F22, F59 & F50). Minimal Region 2 (MR2) is defined by the two largest families F22 and F48, as well as F50. The sequence available from the human genome sequencing project for these two regions is largely complete. Here, I describe an extension to the BAC map in the repetitive telomeric end of MR1. The telomeric end of MR1 is defined by a recombination event in an individual from F50. I describe construction of a transcript map of MR1 and 2 using bioinformatics methods, RT-PCR and cDNA library screening. I then selected two candidate genes from this region: orphan g protein coupled receptor 78 (GPR78) and superoxide dismutase 3 (SOD3), for further study. Firstly, I identified SNPs in the genes from the linked families, and then carried out a preliminary association study on 100 Schizophrenic patients, 100 Bipolar Affective disorder patients 100 controls. The linkage disequilibrium (LD) between the markers was measured and, using a low stringency significant p-value cut off, revealed a positive association in GPR78. SNPs were then tested on a larger population for association. This work adds to the case for studying chromosome 4 for its role in the genetic susceptibility to affective disorder.
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Walker, Rosie May. "Investigation of putative regulatory loci relevant to the pathogenesis of psychiatric illness." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8072.
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The genetic contribution to the aetiology of psychiatric illness is well-established; however, few variants that alter the encoded protein have been irrefutably identified as causative, leading to the hypothesis that variants affecting gene regulation may play a pathogenic role. This thesis focuses on two genes, Neuregulin 1 (NRG1) and Disrupted in Schizophrenia 1 (DISC1), for which there is strong genetic evidence for involvement in psychiatric illness, as well as evidence for altered expression in patients. Association analysis was carried out to assess the involvement of six intronic NRG1 single nucleotide polymorphisms (SNPs) in schizophrenia and bipolar disorder in two independent samples from the Scottish (Scottish 2; n = 307 control subjects, 303 schizophrenic patients, and 239 bipolar disorder patients and German populations (n = 397 control subjects, 396 schizophrenic patients, and 400 bipolar disorder patients). These SNPs form two haplotypes, one encompassing the 5’ and promoter region of the gene and the other located at the 3’ end of the gene, that were previously associated with schizophrenia and bipolar disorder in a Scottish sample (Scottish 1). The location of these haplotypes, together with the prior evidence for altered NRG1 expression in schizophrenia, suggested the potential involvement of regulatory variants. On combining the Scottish 1 and Scottish 2 samples (combined n = 765 control subjects, 682 schizophrenic patients and 601 bipolar disorder patients), a two- SNP haplotype spanning both coding and non-coding regions in the 3’ region was associated with schizophrenia (p = 0.0037, OR=1.3, 95% CI: 1.1-1.6) and the combined schizophrenia and bipolar disorder case group (p = 0.0080, OR=1.2, 95% CI: 1.1-1.5), with both these associations remaining significant after permutation analysis (p = 0.022 and p = 0.044, respectively). To further understanding of how DISC1, a leading candidate gene for schizophrenia that has also been implicated in other psychiatric disorders, is regulated the previously uncharacterised promoter region was assessed both bioinformatically and in vitro using the dual luciferase reporter assay. The region was found to lack canonical promoter motifs but to contain a CpG island, consistent with DISC1’s ubiquitous pattern of expression. A region located 300bp to -177bp relative to the transcription start site (TSS) was identified as contributing positively to DISC1 promoter activity, whilst a region -982bp to -301bp relative to the TSS was found to confer a repressive effect. FOXP2, a transcription factor which is mutated in a rare speech and language disorder and implicated in autism pathogenesis, was found to repress transcription from the DISC1 promoter. Two pathogenic FOXP2 point mutations reduced this transcriptional repression. Preliminary evidence for a bi-directional regulatory relationship between DISC1 and FOXP2 was observed: a mouse model of schizophrenia that carries a Disc1 L100P amino acid substitution and shows altered developmental Disc1 expression was also found to show altered developmental expression of Foxp2. These results further understanding of two genes whose altered expression might contribute to the pathogenesis of psychiatric illness.
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Brown-Beasley, Michael Warren. "Modern American psychiatric diagnosis and the DSM : critiques of impure reason." Thesis, University of Wales Trinity Saint David, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683342.
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King, Elizabeth Anne. "A study of violent death and mental illness in a catchment area population." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293604.
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Cheetham, John L. H. "Relating on psychiatric inpatient units." Thesis, Canterbury Christ Church University, 2014. http://create.canterbury.ac.uk/12833/.
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Research has shown interpersonal relationships to influence experiences of inpatient psychiatric services. This study explored staff and service-users’ talk about relating, and consequences of available/limited social actions. A Foucauldian discourse analysis was used to analyse transcripts from semi-structured interviews and focus groups with current inpatient staff members and service-users with prior experience of being a psychiatric inpatient. Two focus groups (service-users n=10; staff n=6) and five interviews (service-users n=2; staff n=3) were held, with participants responding to questions regarding the discursive object of ‘experiences of relating on inpatient wards’. A dominant ‘medical-technical-legal discourse’ was seen, with two counter-discourses of ‘ordinary humane relating’, and ‘person-centred’. A ‘civil rights’ discourse was drawn on by service-users in the tensions between discourses. The study concluded that the medical-technical-legal discourse perpetuates notions of mental illness as impenetrable to relating. Fearing of causing harm and staff positions of legal accountability generates mistrust, obstructing relating. Ordinary humane relating was vital for service-users in regaining a sense of self. Through ordinary humane relating, a therapeutic relationship could develop, as constructed through a person-centred discourse.
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Scicchitano, Janice Patricia. "Identification and management of somatization in the primary care setting, in terms of illness behaviour and risk of psychiatric illness." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phs416.pdf.
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Bibliography: leaves 233-306. A study of the phenomenon of somatization as it occurs in the primary care setting. The phenomenon was studied in terms of aspects of illness behaviour and risk of psychiatric morbidity. It is suggested that abnormal illness behaviour in the form of somatization may be an important factor in the non-recognition of mild non-psychotic psychiatric illness in the primary care setting. The results of the study indicate that an assessment of the patients' attitudes and beliefs about symptoms, and an exploration of psychosocial issues, may lead to a better understanding of why the patients have sought help, and may lead to early identification and appropriate treatment of somatizing behaviour and the psychiatric morbidity underlying such behaviour.
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Lauder, William James. "Constructions of self-neglect." Thesis, University of Stirling, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322067.
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Payne, S. "Did she fall or was she pushed? : A study of material and social deprivation amongst female psychiatric patients." Thesis, University of Bristol, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381415.
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Sanchez, Phyllis Nancy. "Psychiatric diagnosis vs medical diagnosis: Are mental health professionals aware?" Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184826.
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For years research has demonstrated a varying incidence of medical disorders manifesting with psychiatric symptoms. A relatively conservative estimate of such so called "medical masquerades" is around 10%. It is important to ascertain whether health care professionals are aware of possible medical masquerades perhaps most especially in a mental health center outpatient setting where non-medically trained clinicians are the first line therapists for treatment in the majority of cases. This study set about to find out how aware three types of health care clinicians (psychiatrists, nonpsychiatrically trained medical doctors, and non-medically trained mental health psychotherapists) are of the prevalence of medical masquerades, and whether these three types of clinicians perform differently on three types of clinical vignettes (psychiatric, somatoform, and medical masquerades). Results revealed that all health care professionals surveyed are aware that there are a percentage of medical masquerades in the clinical population. Results also revealed that the three types of clinicians performed differently on the case vignettes.
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Jonsson, Sara, and Tove Lundgren. "Åter på undantag? : Sjuksköterskors erfarenheter av hur egenvård tillämpas inom psykiatrisk omvårdnad." Thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-113501.
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Bakgrund: I Sverige beräknas 14-20% av befolkningen lida av psykisk ohälsa. Egenvård är handlingar som utförs i syfte att upprätthålla hälsa och är central inom den psykiatriska omvårdnaden. Sjuksköterskor möter personer med psykisk ohälsa i olika vårdsituationer och därför krävs kompetens om hur egenvård bör tillämpas i den psykiatriska omvårdnaden. Syfte: Att beskriva sjuksköterskors erfarenheter av hur egenvård tillämpas inom psykiatrisk omvårdnad. Metod: Kvalitativ intervjumetod med induktiv ansats tillämpades. Studien genomfördes inom öppen- och slutenvårdspsykiatrin i en mellanstor svensk kommun. Materialet bestående av nio intervjuer transkriberades och analyserades därefter med hjälp av konventionell innehållsanalys. Resultat: Sjuksköterskorna arbetade utifrån ett professionellt förhållningssätt i syfte att utbilda patienten och individanpassa vården. De beskrev att egenvård som begrepp sällan användes men att de tillskrev många omvårdnadshandlingar till just egenvård. Sjuksköterskorna beskrev att insikt, eget ansvar, motivation och delaktighet var förmågor som var avgörande hos patienten för en fungerande egenvård. Sjuksköterskorna erfor dock att en allt för stor tilltro till medicineringen och bristande kompetens hos vårdgivarna bidrog till att patienternas egenvård försummades då problem ofta löstes kortsiktigt och patienterna blev kvarvarande inom psykiatrin. Konklusion: Bland de intervjuade sjuksköterskornas var den generella uppfattningen att egenvårdsfilosofin inte har anammats inom den psykiatriska omvårdnaden, vilket resulterar i att patienterna blir kvar inom den psykiatriska vården under en obefogat lång tid genom att patienternas sjukdomsförlopp förlängs.Background: In Sweden, 14-20 percent of the population has reduced psychiatric health. Self-care is actions done to maintain health and is crucial in psychiatric nursing care. Nurses meet people with reduced psychiatric health in care situations and therefore knowledge about how self-care should be used in the care of the psychiatric patient is important. Aim: The aim of this study was to describe nurses’ experience of how self-care is applied in psychiatric nursing care. Method: A qualitative interview study was conducted in out- and incare psychiatric care in a middle-size Swedish municipality. Nine interviews was transcribed and thereafter analyzed with a conventional content analysis. Result: The nurses was found to work from a professional approach in order to educate and individualize care. They described that the concept of self-care was rarely used but that they ascribed many actions of nursing care to self-care. The nurses described that insight, responsibility, motivation and participation were the determinant abilities of the patient for a functional self-care. Yet, nurses believed that a greater faith for the medication and lack of competence of the care givers contributed to neglection of the patients’ self-care when problems often were short-term solved and the patients remained in psychiatric care. Conclusion: In the group of interviewed nurses, the general opinion was that the concept of self-care not has been embraced in psychiatric nursing care. According to the nurses, it results in patients remaning in psychiatric care during an unjustified long time and that the course of illness becomes extended.
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Bradfield, Bruce Christopher. "The phenomenology of psychiatric diagnosis: an exploration of the experience of intersubjectivity." Thesis, Rhodes University, 2003. http://hdl.handle.net/10962/d1002450.
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This work is born out of previous research, conducted by this researcher, into the effects of psychiatric labelling on individuals thus differentiated. Informed by the investigative thrust of phenomenological inquiry, it is the aim herein to provide an illumination of the dramatic confrontation of the labelled individual with the classificatory branding that is his or her label. The question asked is: What is the experience of the labelled individual, and how does the label function as a ‘scientific fact’ (Kiesler, 2000) suffused within his being? In answering these questions, the researcher aims to abandon his own expectations, as is fitting with the phenomenological method, and to devote his sympathies entirely to the subjective disclosures which, it is hoped, the participants will offer. On this point, an obvious tension exists insofar as expectation and hypothesis necessarily constitute the inception of any research endeavour; and so, the notion of a complete bracketing of assumption and anticipation seems methodologically vague. The explorative impetus within this dissertation aims towards an elucidation of the effect of psychiatric diagnosis on the labelled individual, in terms of the individual’s experience of being-with-others. The impact of the offering of the label upon the individual’s interpersonal and intersubjective presence will be explored so as to establish whether psychiatric labelling unfolds as a disconnection of the individual from his co-existence with others.
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Allan, Keina. "Metacognitive strategies and problem-solving with an adult subject living with chronic psychiatric illness." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0010/MQ60069.pdf.
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Spiro, Monica. "Illness models of relatives of African psychiatric patients : implications for a family-based service." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/13544.
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Bibliography: leaves 42-46.This study explores the illness models and service requests of relatives of 30 African psychiatric patients. Relatives' perceptions of illness and expressed needs were elicited with a view to developing a more contextual understanding of disorder, and to obtaining an indication of interest in family-based services. The sample was selected from relatives who visited patients at the hospital over a 3 month period. Face-to-face interviews of approximately an hour in duration were conducted. Results indicated that relatives held a variety of explanatory models to understand their family members' conditions. Although many of their beliefs were at variance with the biomedical model of illness, they nevertheless overwhelmingly supported the notion of the establishment of family-based / services within the existing health care system. Implications for strategies of clinical care, as well as theoretical implications are discussed.
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Sha, Li. "Transcriptional regulation of neurodevelopmental and metabolic pathways by the psychiatric illness candidate gene NPAS3." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5578.
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The basic helix-loop-helix PAS domain transcription factor gene NPAS3 is a risk factor for psychiatric disorders. A knockout mouse model also exhibits behavioural and adult neurogenesis deficits consistent with human illness. To define the location and mechanism of NPAS3 aetiopathology immunofluorescent and transcriptomic approaches were used. Npas3 was co-localised with Dcx, but not other neurogenesis markers, in the hippocampal subgranular zone - the site of adult neurogenesis. This implied that NPAS3 might be involved in maturing, rather than proliferating, neuronal precursor cells. Microarray analysis revealed that the transcriptional activities of NPAS3 and its truncated form (C-terminal deletion) in the HEK293 cell line are sensitive to circadian rhythm context. The most highly up-regulated NPAS3 target gene, VGF, encodes secretory peptides with established roles in neurogenesis, depression and schizophrenia. VGF was one of many NPAS3 target genes also shown to be regulated by the SOX family of transcription factors, suggesting an overlap in neurodevelopmental pathways. The transcriptional repression of multiple glycolytic genes indicated that NPAS3 has a second role in metabolic regulation. This finding was also confirmed by collaboration with a metabolomics research group at the University of Strathclyde. SOX11, a transcription factor known to play a role in neuronal and glial cell differentiation, was shown to be down-regulated by NPAS3. The set of genes targeted by SOX11 and their ontologies were deduced by a microarray analysis in a SOX11 overexpressing HEK293 cell line. Regulated genes include a previously established SOX11 target, known markers of neurogenesis as well as genes implicated in neuropsychiatric disorders. Multiple histone and zinc finger genes are regulated by SOX11, many of which were located in two clusters on chromosomes 6 and 19. The chromosome 6 cluster lies within a region of the genome showing the strongest genetic association with schizophrenia. SOX11 may alter localised expression competence and its targets induce a complex programme of chromatin remodelling and downstream gene expression changes to achieve the mature neuronal phenotype. This thesis details how transcription factors are involved in biological processes linked to psychiatric illness. The dual neurodevelopmental and metabolic aspects of NPAS3 activity described here increase our understanding of aspects of neurogenesis relevant to mental illness and may explain the innate and medication-induced susceptibility to diabetes reported in psychiatric patients.
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Skene, Allyson. "Psychiatric classification, medicine and madness an examination of Ontology and Epistemology in DSM-IV /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0005/NQ43452.pdf.
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Morgan, Vera Anne. "Intellectual disability co-occurring with schizophrenia and other psychiatric illness : epidemiology, risk factors and outcome." University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0209.
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(Truncated abstract) The aims of this thesis are: (i) To estimate the prevalence of psychiatric illness among persons with intellectual disability and, conversely, the prevalence of intellectual disability among persons with a psychiatric illness; (ii) To describe the disability and service utilisation profile of persons with conjoint disorder; (iii) To examine, in particular, intellectual disability co-occurring with schizophrenia; and (iv) To explore the role of hereditary and environmental (specifically obstetric) risk factors in the aetiology of (i) intellectual disability and (ii) intellectual disability co-occurring with psychiatric illness. This thesis has a special interest in the relationship between intellectual disability and schizophrenia. Where data and sample sizes permit, it explores that relationship at some depth and has included sections on the putative nature of the link between intellectual disability and schizophrenia in the introductory and discussion chapters. To realise its objectives, the thesis comprises a core study focusing on aims (i) (iii) and a supplementary study whose focus is aim (iv). It also draws on work from an ancillary study completed prior to the period of candidacy...This thesis found that, overall, 31.7% of persons with an intellectual disability had a psychiatric illness; 1.8% of persons with a psychiatric illness had an intellectual disability. The rate of schizophrenia, but not bipolar disorder or unipolar major depression, was greatly increased among cases of conjoint disorder: depending on birth cohort, 3.7-5.2% of individuals with intellectual disability had co-occurring schizophrenia. Down syndrome was much less prevalent among conjoint disorder cases despite being the most predominant cause of intellectual disability while pervasive developmental disorder was over-represented. Persons with conjoint disorder had a more severe clinical profile including higher mortality rates than those with a single disability. The supplementary study confirmed the findings in the core body of work with respect to the extent of conjoint disorder, its severity, and its relationship with pervasive development disorder and Down syndrome. Moreover, the supplementary study and the ancillary influenza study indicated a role for neurodevelopmental insults including obstetric complications in the adverse neuropsychiatric outcomes, with timing of the insult a potentially critical element in defining the specific outcome. The supplementary study also added new information on familiality in intellectual disability. It found that, in addition to parental intellectual disability status and exposure to labour and delivery complications at birth, parental psychiatric status was an independent predictor of intellectual disability in offspring as well as a predictor of conjoint disorder. In conclusion, the facility to collect and integrate records held by separate State administrative health jurisdictions, and to analyse them within the one database has had a marked impact on the capacity for this thesis to estimate the prevalence of conjoint disorder among intellectually disabled and psychiatric populations, and to understand more about its clinical manifestations and aetiological underpinnings.
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Jonsson, Caroline, and Bergh Aina James. "Knowledge, Contribution and Social factors : A qualitative study about psychiatric social work in Goa, India." Thesis, Ersta Sköndal högskola, Institutionen för socialvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-2252.
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Social work is one of the core mental health professions. With a dominance of a biological model in psychiatry, the scope of social factors has been relatively marginal. Social factors have been argued to be social work ́s area of expertise. Psychiatric social work is challenged to articulate its unique knowledge and valuable contribution to the field of mental health care since they are coexisting with other more well-established professions. This qualitative study explores how psychiatric social workers and psychiatrists in Goa, India, perceive social work's unique knowledge and its contribution to the field of mental health care. It further explores psychiatric social workers understanding of social factors in relation to mental illness. The empirical material was collected through twelve semi-structured interviews with ten psychiatric social workers and two psychiatrists working in different mental health care settings in Goa. The results show that the main psychiatric social work contributions were described as raising awareness about mental illness and their functioning as a bridge between units. The result further shows a difficulty (among psychiatric social workers) to articulate psychiatric social work's unique knowledge, but during the interviews a specific in-depth knowledge emerged as well as a focus on psychiatric knowledge. Our findings showed that psychiatric social workers understood social factors in terms of social relations. The results are analyzed with Foucault's theory of discourse, Polanyi's theory of tacit knowledge and Ingleheart’s modernization theory.
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Brinkman, John J. "Psychiatric disorders as an outcome of neurological insult : a computation of relative risk." Virtual Press, 2004. http://liblink.bsu.edu/uhtbin/catkey/1301628.
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The purpose of this study was to examine the relative risk of psychiatric disorders occurring in patients diagnosed with neurological disorders. This study separately computed the relative risk ratios for identified psychiatric disorder (i.e., anxiety, mood disorders, somatization, schizophrenia, alcohol abuse, and antisocial personality disorder) on seven of the more common neurological disorders (i.e., brain tumor, closed head injury, stroke, dementia, multiple sclerosis, cerebral palsy, and Parkinson's disease). The six psychiatric disorders were chosen based on the epidemiological catchment area (ECA) research (Robins & Reigier 1991) and provided the control group of psychiatric disorders in the general population by which comparisons were made to the neurological care setting. The neurological disorders were included based on the frequency of referrals to a neuropsychological practice. Further, this study provided an overall relative risk ratio of psychiatric disorders for all seven neurological disorders considered together.Participants in this study included a sample of 367 consecutive referrals to a neurology practice in the Midwest. All of the 376 subjects were diagnosed with a neurological disorder. Two hundred forty-six of the subjects were diagnosed with a neurological disorder and no psychiatric disorder. One hundred twenty-one of the subjects were diagnosed with both a neurological and a psychiatric disorder. The MMPI2 was used in the assessment and diagnosis of psychiatric disorders. The control group, represented by the ECA study, was composed of 19,640 participants.Relative risk estimates were made using cross products ratio. Significance of the risk ratio was tested using Chi-square Continuity Correction values. Power analysis was conducted using Fisher's Exact Test.The results of the analysis suggested that patients with neurological disorders are more likely to present with psychiatric disorders compared to the general population. The overall relative risk for this study revealed that patients were 1.669 times more likely to have a comorbid psychiatric disorder following the diagnosis of a neurological disorder. Additionally, three individual disorders had relative risk ratios suggesting an increase in psychiatric disorders above the risk in the general population. These three conditions included stroke (RR = 3.038), dementia (RR = 2.762), and multiple sclerosis (RR = 3.617).Department of Educational Psychology
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Pinfold, Vanessa Anne. "Community connections : geographies of rehabilitation amongst people with long term and enduring mental health problems in Nottingham." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324061.
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Khan, K. "Psychiatric morbidity amongst ex Far East prisoners of war more than thirty years after repatriation." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381265.
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Bools, Chriistopher N. "Fabricated and induced illness ('Munchausen syndrome by proxy') : a psychiatric study of parents and children." Thesis, University of Manchester, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499915.
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Dulek, Erin. "Psychiatric Hospitalization and Resiliency: Experiences of Adults with Serious Mental Illness Upon Reentering their Communities." Bowling Green State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1541508046445646.
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James, Rachel. "Antibody characterisation of DISC1, a gene identified at a chromosomal translocation associated with psychiatric illness." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/28295.
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DISC1 (Disrupted in Schizophrenia) was identified at the breakpoint of a chromosomal translocation associated with schizophrenia and other psychiatric illnesses in a large Scottish family. Recent linkage studies have also identified the DISC1 locus as a susceptibility factor for schizophrenia in Finnish families and DISC1 is emerging as a candidate gene for psychiatric illness. At the time of identification DISC1 was novel and the function of the DISC1 protein was completely unknown. To characterise the function of DISC1, antibodies were raised against the DISC1 protein using both a peptide and bacterially expressed recombinant protein as the antigen. The resulting antibodies were characterised thoroughly to ensure their specificity for DISC1. Multiple transcripts of DISC1 had been identified and the initial aim was to determine which of the transcripts were translated into functional proteins. Multiple DISC1-related proteins were found to exist in human but only a single isoform was identified in mouse and rat. In addition the protein expression levels of DISC1 were examined in lymphoblastoid cell lines derived from members of the original translocation family. No evidence for a truncated protein resulting from the translocated chromosome was found but preliminary results suggest that levels of DISC1 are significantly reduced in translocation carriers. The subcellular localisation of DISC1 was studied in human neuroblastoma and glioblastoma cell lines. DISC1 was found to colocalise with mitochondria in a cytoskeletal associated with pattern, and in differentiated neuroblastoma cells DISC1 localised to the tips of developing neurites suggesting a possible role in neurite outgrowth. Further characterisation of the function of DISC1 should now focus on its relationship with the mitochondria to ascertain the significance of this association to both the function and subsequent dysfunction of the nervous system.
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Rice, Judy A. "The Great Masquerade: Medical Conditions that Mimic Mental Illness." Digital Commons @ East Tennessee State University, 2001. https://dc.etsu.edu/etsu-works/7611.
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Alvarado, Chavarría María Jimena. "Let's Try to Change It: Psychiatric Stigmatization, Consumer/Survivor Activism, and the Link and Phelan Model." PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/904.
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Stigma has been described as the most significant obstacle to quality of life for individuals with major psychiatric diagnoses (Sartorious, 1998). Much of the psychological literature on stigma focuses on individual attributes and interactions at the micro level, rather than macro level dynamics. In critiquing this traditional focus, Link and Phelan (2001) present a model in which stigma ensues when labeling, stereotyping, separation, status loss, and discrimination co-occur in a situation of power imbalance. Even as the model fills a gap in conceptualizing stigma, its emphasis on power is unidirectional and fails to account for power as a form of resistance to stigmatization. This study explores the question of how a consumer/survivor activist perspective can inform the Link and Phelan model of stigma. A semi-structured interview methodology was used to gather qualitative data on the perspectives of 10 activists who are both the targets of stigma and active change agents in resisting stigma. The content of the interviews was thematically analyzed based on an iterative coding approach in order to identify the points of overlap with and divergence from the Link and Phelan model. The results of the study support the applicability of the model for psychiatric stigma. The participants' experiences illustrate which aspects of stigmatization take precedence in this context, indicating significant points for intervention. The anti-stigma work discussed by the participants illustrates the power of grassroots resistance, expanding the understanding of power presented in the model. Emergent discursive themes include the importance of similarity, the rejection of negative portrayals of mental illness, and a focus on a shared continuum of human experience. Participants' emphasis on the importance of having their voices silenced was a particularly recurring motif. Several respondents challenge the premises of the Link and Phelan model. These participants emphasize the positive aspects of diagnosis and labeling, while several other participants reject the choice of the term stigma because it may obscure the structural aspects of discrimination. These findings can serve as a guideline for designing future interventions, and focusing on strategies for social change.
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Bromet, Elizabeth. "The relationship between vocational rehabilitation services, demographic variables and outcomes among individuals with psychiatric disabilities." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1116127984.
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Strömberg, Gunvor. "Serious mental illness : early detection and intervention by the primary health service. /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-312.
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Lloyd, Donald Arthur. "Socioeconomic consequences of early-onset psychiatric disorders, mental illness and stress in a life course perspective." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ50000.pdf.
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Moussa, Abdulla. "The effect of Housing First on psychiatric symptoms of homeless individuals with mental illness in Vancouver." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44924.
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Background: Mental illness can directly worsen and prolong the experience of homelessness. Housing First has been a promising approach to dealing with chronic homelessness, demonstrating improvements in several areas except psychiatric symptoms. The purpose of this thesis is to examine the role that the Housing First approach plays on alleviating self-reported psychiatric symptoms of homeless adults with serious mental illness during a two year period.
Methods: 497 participants were recruited as part of the Vancouver site of the At Home/ Chez Soi study, a national randomized control trial examining the impact of Housing First in five Canadian cities. Participants were allocated to either a High Needs or Moderate Needs arm based on their individual levels of need and psychosis. Within each study arm, participants were randomly assigned to different forms of Housing First and treatment support, or the usual treatment. The Colorado Symptom Index (CSI) was used to measure self-reported psychiatric symptoms at baseline and every 6 months for a period of 24 months. Total CSI mean scores were used to compare groups within each study arm at each time point.
Results: There were no significant differences in total CSI mean scores at any time point during the 2 years between Housing First or treatment as usual groups of either study arm.
Conclusion: Groups receiving Housing First and groups receiving treatment as usual reported similar decreases in psychiatric symptoms over time. Future research can examine individual service-use to shed more light on services most effective in alleviating psychiatric symptoms.