Academic literature on the topic 'Psammomys Obesus'
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Journal articles on the topic "Psammomys Obesus"
Sanigorski, A., D. Cameron-Smith, P. Lewandowski, K. Walder, A. de Silva, G. Morton, and GR Collier. "Impact of obesity and leptin treatment on adipocyte gene expression in Psammomys obesus." Journal of Endocrinology 164, no. 1 (January 1, 2000): 45–50. http://dx.doi.org/10.1677/joe.0.1640045.
Full textLevy, Emile, Geneviève Lalonde, Edgard Delvin, Mounib Elchebly, Louis P. Précourt, Nabil G. Seidah, Schohraya Spahis, Rémi Rabasa-Lhoret, and Ehud Ziv. "Intestinal and Hepatic Cholesterol Carriers in Diabetic Psammomys obesus." Endocrinology 151, no. 3 (February 3, 2010): 958–70. http://dx.doi.org/10.1210/en.2009-0866.
Full textHeled, Yuval, Yair Shapiro, Yoav Shani, Dani S. Moran, Lea Langzam, Liora Braiman, Sanford R. Sampson, and Joseph Meyerovitch. "Physical exercise prevents the development of type 2 diabetes mellitus in Psammomys obesus." American Journal of Physiology-Endocrinology and Metabolism 282, no. 2 (February 1, 2002): E370—E375. http://dx.doi.org/10.1152/ajpendo.00296.2001.
Full textWalder, K., M. Willet, P. Zimmet, and G. R. Collier. "Ob (obese) gene expression and leptin levels in Psammomys obesus." Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1354, no. 3 (November 1997): 272–78. http://dx.doi.org/10.1016/s0167-4781(97)00083-3.
Full textKalman, R., E. Ziv, E. Shafrir, H. Bar-On, and R. Perez. "Psammomys obesus and the albino rat-two different models of nutritional insulin resistance, representing two different types of human populations." Laboratory Animals 35, no. 4 (October 1, 2001): 346–52. http://dx.doi.org/10.1258/0023677011911949.
Full textBendayan, M., D. Malide, E. Ziv, E. Levy, R. Ben-Sasson, R. Kalman, H. Bar-On, M. Chrétien, and N. Seidah. "Immunocytochemical investigation of insulin secretion by pancreatic beta-cells in control and diabetic Psammomys obesus." Journal of Histochemistry & Cytochemistry 43, no. 8 (August 1995): 771–84. http://dx.doi.org/10.1177/43.8.7622840.
Full textLeckström, A., E. Ziv, E. Shafrir, and P. Westermark. "Islet Amyloid Polypeptide in Psammomys obesus (Sand Rat)." Pancreas 15, no. 4 (November 1997): 358–66. http://dx.doi.org/10.1097/00006676-199711000-00005.
Full textOmari, N., F. Hadj Bekkouche, S. Aouichat-Bouguerra, and Y. Dahmani-Ait Akli. "Syndrome métabolique chez un rongeur déserticole (Psammomys obesus)." Journal des Maladies Vasculaires 38, no. 2 (March 2013): 133. http://dx.doi.org/10.1016/j.jmv.2012.12.045.
Full textSteinbach, T. J., and J. D. Kane. "Brunner’s Gland Hyperplasia in the Sand Rat (Psammomys obesus)." Veterinary Pathology 50, no. 4 (September 6, 2012): 709–14. http://dx.doi.org/10.1177/0300985812459338.
Full textHamlat, N., S. Neggazi, Y. Benazzoug, G. Kacimi, M. Ardjoun, M. C. Bourdillon, and S. Aouichat-Bouguerra. "Tu-P7:45 Psammomys obesus, animal model of atherosclerosis." Atherosclerosis Supplements 7, no. 3 (January 2006): 194. http://dx.doi.org/10.1016/s1567-5688(06)80753-1.
Full textDissertations / Theses on the topic "Psammomys Obesus"
Lewandowski, Paul, and mikewood@deakin edu au. "Liver fat metabolism, obesity and diabetes in Psammomys Obesus." Deakin University. School of Health Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050825.111432.
Full textSouthon, Adam, and mikewood@deakin edu au. "Novel genes in the liver of diabetic psammomys obesus." Deakin University. School of Health Sciences, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051201.150429.
Full textMenad, Rafik. "Régulation fonctionnelle de l’épididyme d’un rongeur déserticole, Psammomys obesus, CRETZSCHMAR, 1828." Thesis, Paris, EPHE, 2015. http://www.theses.fr/2015EPHE3011.
Full textIn order to highlight the main elements of androgen and estrogen pathway in the epididymis of sand rat, captured in Beni Abbès area, in Algeria, androgen receptor (AR), aromatase, estradiol, estrogen receptors (ERα, ERβ and GPR30) were explored in breeding season, in resting season and in animals underwent castration, castration then testosterone treatment and ligation of efferent ducts. In breeding season, AR has a ubiquitous distribution, aromatase is exclusively cytoplasmic and estradiol is nuclear and cytoplasmic. The ERα and GPR30 were distributed with a high intensity in the apical cytoplasm contrarily to ERβ which were nuclear. In resting season, AR, aromatase, estradiol, ERα persist with lower staining. However, ERβ undergo cytoplasmic translocation and GPR30 persist in cytoplasm. In castrated animals, AR, aromatase and estradiol are reduced. ERα persist with low intensity in the apical cytoplasm. GPR30 is distributed in the cytoplasm and the nucleus. In castrated then treated animals, AR is restored; aromatase and estradiol reappear with a cytoplasmic localization for aromatase, nuclear and apical for ERα. ERβ and GPR30 are restored and have a cytoplasmic localization. In ligatured, RA is preserved in the caput, aromatase and estradiol persist caput and cauda. The signal of ERα, ERβ and GPR30 is highly expressed in the nucleus and cytoplasm of caput epididymis and highly expressed of ERα exclusively in cauda. By Western blot, RA, ERα, ERβ and GPR30 are found with molecular weights of 122, 64, 55 and 55 kDa respectively
Menad, Rafik. "Régulation fonctionnelle de l’épididyme d’un rongeur déserticole, Psammomys obesus, CRETZSCHMAR, 1828." Electronic Thesis or Diss., Paris, EPHE, 2015. http://www.theses.fr/2015EPHE3011.
Full textIn order to highlight the main elements of androgen and estrogen pathway in the epididymis of sand rat, captured in Beni Abbès area, in Algeria, androgen receptor (AR), aromatase, estradiol, estrogen receptors (ERα, ERβ and GPR30) were explored in breeding season, in resting season and in animals underwent castration, castration then testosterone treatment and ligation of efferent ducts. In breeding season, AR has a ubiquitous distribution, aromatase is exclusively cytoplasmic and estradiol is nuclear and cytoplasmic. The ERα and GPR30 were distributed with a high intensity in the apical cytoplasm contrarily to ERβ which were nuclear. In resting season, AR, aromatase, estradiol, ERα persist with lower staining. However, ERβ undergo cytoplasmic translocation and GPR30 persist in cytoplasm. In castrated animals, AR, aromatase and estradiol are reduced. ERα persist with low intensity in the apical cytoplasm. GPR30 is distributed in the cytoplasm and the nucleus. In castrated then treated animals, AR is restored; aromatase and estradiol reappear with a cytoplasmic localization for aromatase, nuclear and apical for ERα. ERβ and GPR30 are restored and have a cytoplasmic localization. In ligatured, RA is preserved in the caput, aromatase and estradiol persist caput and cauda. The signal of ERα, ERβ and GPR30 is highly expressed in the nucleus and cytoplasm of caput epididymis and highly expressed of ERα exclusively in cauda. By Western blot, RA, ERα, ERβ and GPR30 are found with molecular weights of 122, 64, 55 and 55 kDa respectively
Zoltowska, Monika. "Désordres de l'homéostasie lipidique durant le développement du diabète non-insulino dépendant chez le psammomys obesus." [Montréal] : Université de Montréal, 2002. http://wwwlib.umi.com/cr/umontreal/fullcit?pNQ82716.
Full text"NQ-82716." "Thèse présentée à la faculté des études supérieures en vue de l'obtention du grade de philosophiae doctor (Ph. D.) en nutrition." Version électronique également disponible sur Internet.
Hamlat, Nadjiba. "Lipogénèse de la paroi artérielle : régulation de son expression et anomalies dans l'insulino-résistance et le diabète." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10071.
Full textWe investigated the expression and regulation of lipogenesis in aortas and VSMC and determined if it is modified during metabolic abnormalities. Zucker obese (ZO), diabetic (ZDF) rats, and the high fat diet fed Psammomys obesus accumulated more triglycerides in their aortas than control rats. However the expression of lipogenic genes, or of genes involved in fatty acids uptake, was not increased. Lipogenesis was not increased in human carotid endarterectomy of diabetic compared to non-diabetic patients. The adipogenic medium (ADM), glucose or insulin stimulated moderately lipogenesis but only in VSMC from control rats. No effect was observed in VSMC from ZO. We showed that the lipogenic effects of TO901317observed in VSMC from Zucker control rats are due solely to the nuclear receptor LXRα, PXR agonist had no effect. Conclusion: Lipogenesis is not increased in arterial wall during insulin-resistance and diabetes
Hamlat, Nadjiba. "Lipogénèse de la paroi artérielle : régulation de son expression et anomalies dans l'insulino-résistance et le diabète." Electronic Thesis or Diss., Lyon 1, 2010. http://www.theses.fr/2010LYO10071.
Full textWe investigated the expression and regulation of lipogenesis in aortas and VSMC and determined if it is modified during metabolic abnormalities. Zucker obese (ZO), diabetic (ZDF) rats, and the high fat diet fed Psammomys obesus accumulated more triglycerides in their aortas than control rats. However the expression of lipogenic genes, or of genes involved in fatty acids uptake, was not increased. Lipogenesis was not increased in human carotid endarterectomy of diabetic compared to non-diabetic patients. The adipogenic medium (ADM), glucose or insulin stimulated moderately lipogenesis but only in VSMC from control rats. No effect was observed in VSMC from ZO. We showed that the lipogenic effects of TO901317observed in VSMC from Zucker control rats are due solely to the nuclear receptor LXRα, PXR agonist had no effect. Conclusion: Lipogenesis is not increased in arterial wall during insulin-resistance and diabetes
Harmel, Élodie. "Rôle et régulation de la protéine kinase AMPK au niveau intestinal." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00934093.
Full textZoltowska, Monika. "Désordres de l'homéostasie lipidique durant le développement du diabète non-insulino dépendant chez le psammomys obesus." Thèse, 2002. http://hdl.handle.net/1866/14898.
Full textBen, Djoudi Ouadda Ali. "Caractérisation de la voie de signalisation AMPK/ACC dans le foie et l’intestin du Psammomys obesus, un modèle animal de résistance à l’insuline et de diabète de type 2." Thèse, 2008. http://hdl.handle.net/1866/2687.
Full textUnderstanding the cellular mechanisms involved in the development of insulin resistance, and later on the occurrence of type 2 diabetes and its metabolic complications, is a perquisite step toward the identification of new therapeutic targets to fight against the development of these metabolic diseases. In the present studies, we used the gerbil Psammomys obesus, a well-established animal model of obesity, insulin resistance (IR) and type 2 diabetes (T2D), to characterize the hepatic and intestinal signaling abnormalities associated with lipid metabolism disorders during the pathogenesis of IR and T2D. Thus, we are able to demonstrate that the development of these metabolic diseases in Psammomys obesus animals, is accompanied by increased hepatic and intestinal lipogenesis with very high efficiency to form triglycerides rich-lipoproteins. In the liver, we observed an increase in mRNA levels of key lipogenic enzymes (ACC, FAS, SCD-1 and mGPAT) and transcription factors (SREBP-1, ChREBP), which modulate the expression level of lipogenic enzymes. Thereafter, our detailed analysis of the AMPK/ACC signaling pathway revealed a rise in the gene expression of the cytosolic ACC1 isoform of ACC(involved in de novo lipogenesis) concomitant with a constant expression of the mitochondrial ACC2 (negative regulator of β-oxidation). In spite of an adaptive state characterized by higher protein expression and phosphorylation (activation) of AMPKα, the kinase that phosphorylates and inhibits ACC, the activity of the later remains very high in IR and T2D animals. In the small intestine of IR and T2D animals, we demonstrated that the increase in intestinal lipogenesis is mainly associated with a decrease of AMPK signaling pathway (i.e. reduced expression and protein phosphorylation/activation of the two AMPKα1 and AMPKα2 isoforms). The main consequence of the decline in AMPK activity is the reduction of ACC phosphorylation. Given that, the expression levels of ACC remain unchanged; our results thus suggest an increased activity of both ACC isoforms, ACC1 and ACC2. Next, we observed a reduction in protein and gene expression of CPT1 [key enzyme in fatty acid (FA) β-oxidation]. Taken together, these results suggest an inhibition of FA β-oxidation concomitant with a stimulation of de novo lipogenesis. Finally, we demonstrated that the small intestine is an insulin sensitive organ and that the development of IR affects two signaling pathways (i.e. Akt/GSK3 and p38MAPK) essentials for several metabolic processes. In conclusion, our results indicate that increased lipogenesis, in IR and T2D, which exacerbate the dyslipidemia associated with these diseases, might be, at least partially, a result of AMPK signaling defects. In addition, our observations illustrate the crucial role of AMPK/ACC in the liver and intestine and validate AMPK as a potential target to treat the metabolic diseases.
Book chapters on the topic "Psammomys Obesus"
Kaiser, Nurit, Erol Cerasi, and Gil Leibowitz. "Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)." In Animal Models in Diabetes Research, 89–102. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-068-7_7.
Full textGruber, Helen E., and Edward N. Hanley. "The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Degeneration." In The Intervertebral Disc, 327–39. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1535-0_20.
Full textKaiser, Nurit, Michal Gadot, Gil Leibowitz, Erol Cerasi, and David J. Gross. "Hyperproinsulinaemia and Islet Dysfuction in the NIDDM-Like Syndrome of Psammomys obesus." In Advances in Experimental Medicine and Biology, 371–78. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1819-2_49.
Full textShafrir, Eleazar, Rony Kalman, and Ehud Ziv. "Psammomys Obesus." In Animal Models of Diabetes, Second Edition, 289–310. CRC Press, 2007. http://dx.doi.org/10.1201/9781420009453.ch13.
Full textMbarek, Sihem, Oumeima Hammami, Oumeima Achour, and Rafika Ben Chaoucha-Chekir. "Gerbil, Psammomys obesus, a human-like rodent model of eye research." In Rodents and Their Role in Ecology, Medicine and Agriculture. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.1002183.
Full text"Psammomys Obesus: Nutritionally Induced Insulin Resistance, Diabetes, and Beta Cell Loss." In Animal Models of Diabetes, 303–24. CRC Press, 2007. http://dx.doi.org/10.1201/9781420009453-17.
Full text"PSAMMOMYS OBESUS: PRIMARY INSULIN RESISTANCE LEADING TO NUTRITIONALLY INDUCED TYPE 2 DIABETES." In Animal Models in Diabetes, 301–15. CRC Press, 2000. http://dx.doi.org/10.4324/9780203304730-23.
Full text"Energy and Nitrogen Requirements of the Fat Sand Rat (Psammomys obesus) When Consuming a Single Halophytic Chenopod." In Halophytic and Salt-Tolerant Feedstuffs, 399–413. CRC Press, 2015. http://dx.doi.org/10.1201/b19862-33.
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