Dissertations / Theses: 'PSA'

1

Schwickardi-Jerrentrup, Maren. "Freies PSA und PSA-Quotient in der Diagnostik des Prostatakarzinoms." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0091/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Eriksson, Carl. "Osäkerhetsanalys av PSA-resultat : Metodutveckling och parameterinventeringför osäkerhetsanalys av PSA-resultat." Thesis, Uppsala universitet, Tillämpad kärnfysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336256.

Full text

Abstract:

This master thesis examines the possibility of performing asimplified uncertainty analysis on a probabilistic safety assessment(PSA) of the Oskarshamn 3 nuclear power plant. The aim of the thesiswas divided in two parts, first to examine the uncertainty parametersof a PSA-model for Oskarshamn 3 and the second part was to developand examine a simplified method of uncertainty analysis as comparedto a more regular method of Monte Carlo-simulation. The thesis ismostly concerned with examining the core damage frequency. Theexamination of uncertainty parameters showed that many parameterswere missing from the model and thus further investigation areneeded, if a full Monte Carlo is to be performed. The simplifiedmethod for uncertainty analysis that was developed consisted ofassuming a lognormal distribution for the frequency of basic eventsand then using the minimal cutset-list to calculate an approximationto the end distribution. The simplified method was then compared tothe Monte Carlo-analysis for Oskarshamn 2 for different MCS-lists anda preliminary uncertainty analysis was performed for Oskarshamn 3.

APA, Harvard, Vancouver, ISO, and other styles

3

Krhut, Štěpán. "Zušlechťování bioplynu metodou PSA." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2017. http://www.nusl.cz/ntk/nusl-318663.

Full text

Abstract:

This work deals with bio gas cleaning by a PSA method and modernizing of a laboratory unit. Raw bio gas contains many unwanted elements like carbon dioxide mostly which lowers its energy potential then. To extend the possibilities of usage of bio gas it is necessary to remove such elements. One of the well-known method for eliminating CO2 out of the bio gas is the method called Pressure Swing Adsorption (PSA). This work describes PSA method and compares it with other methods for cleaning the bio gas. In the following part of my work I am introducing the original laboratory PSA unit which is placed in the laboratory of UPI institution for research purposes. The modernization of the method was made by changing the manual valves for electromagnetic ones and there was also designed a new control system unit for two control modes. For manual and for automatic. The essential function is based on remote controlling the valves either by switches or by a program. The electric control panel was created for such required modes. The automated process was controlled by Arduino programming platform which was integrated into the panel. In the case of the next measurement and reading there was created a detailed description for user on how to operate the control panel and also the comments for control program of automatization.

APA, Harvard, Vancouver, ISO, and other styles

4

Moreira, Horácio Alvarenga. "Um novo índice para detecção do câncer de próstata (razão entre densidade do PSA e PSA livre sobre o PSA total)." Universidade Estadual de Londrina. Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde, 2015. http://www.bibliotecadigital.uel.br/document/?code=vtls000200881.

Full text

Abstract:

Introdução e objetivo: O antígeno prostático específico (PSA) é o mais importante marcador para diagnóstico de câncer de próstata (CaP), porém, em pacientes com níveis intermediários de PSA (entre 2,5 e 20,0 ng/ml), existe uma grande dificuldade para diferenciar casos de CaP daqueles com Hiperplasia Benigna da Próstata (HPB). Apesar do risco considerável de neoplasia, a maior parte destes pacientes, quando investigados por biópsia prostática, apresenta HPB. Desta maneira, biópsias de próstata são realizadas desnecessariamente e as mesmas não são isentas de complicações como prostatite, abscesso, sepses e até óbito. Introduziu-se as porcentagem do PSA livre (%PSAL) e densidade do PSA (DPSA) com o objetivo de aumentar a detecção do CaP (sensibilidade) e diminuir o número de biópsias desnecessárias (especificidade), porém, a utilização isolada destas ferramentas produzem resultados insatisfatórios. Modelos matemáticos como regressão logística com múltiplas variáveis (MRLM) e redes neural artificial apresentam melhores resultados. Entretanto, a complexidade destes cálculos inviabilizam a sua aplicabilidade na prática clínica diária. Baseado na premissa de que quanto menor a porcentagem do PSA e quanto maior a densidade do PSA maior a probabilidade do paciente ter CaP, o objetivo do presente estudo foi avaliar se um NOVO ÍNDICE (NI), obtido pela divisão do valor da densidade do PSA pela relação PSA livre/total, é superior ao uso isolado do PSA, %PSAL, a um MRLM e a DPSA para detecção do CaP. Método: Estudo de avaliação de teste diagnóstico a partir de um banco de dados de três estudos prospectivos, realizados no período de 2002 a 2009, no Hospital Universitário Regional do Norte do Paraná, Hospital do Câncer de Londrina e em cinco clínicas privadas de Londrina-PR, envolvendo 709 homens. Extraiu-se, deste banco de dados, as seguintes variáveis: idade, resultado do exame de toque retal, PSA total, PSA livre, volume da próstata, %PSAL, DPSA e resultado da biópsia de próstata (CaP ou HPB). Dos 709 homens, 466 (162 com CaP e 304 com HPB) tinham dosagem do PSA entre 2,5 e 20 mg/ml e apresentavam, simultaneamente, todas as variáveis acima mencionadas. A capacidade do NI em melhorar a detecção do CaP foi avaliada por análise univariada e multivariada e através de curva ROC. Resultados: O NI apresentou uma acurácia de 76,9% e esta foi superior a do PSA (57,4%), %PSAL (71,2%) e DPSA (73,5%) na discriminação entre CaP e HPB, na faixa de PSA entre 2,5 e 20 ng/ml, aumentando assim a detecção do CaP e diminuindo o número de biópsia de próstata desnecessárias. O NI apresentou uma acurácia semelhante (p=0,2036) a de um MRLM (78,6%). Para uma sensibilidade de 95%, para detecção do CaP, a especificidade (biópsias evitadas) do PSA, %PSAL, DPSA, NI e MRLM foram respectivamente: 8,22%, 18,42%, 20,07%, 20,39% e 26,97%. Conclusão: O NI proporcionou uma melhor discriminação entre CaP e HPB do que o uso isolado do PSA , %PSAL e DPSA. Também apresentou uma acurácia semelhante a de um MRLM, em pacientes com níveis de PSA entre 2,5 e 20 ng/ml. Introduction and objective: Prostatic specific antigen (PSA) is the most important marker for the diagnosis of prostate cancer (CaP). However, in patients with intermediate levels of PSA (between 2.5 and 20, 0 ng/ml), it is difficult to differentiate cases of CaP from those of benign hyperplasia of the prostate (BPH). Despite the considerable risk of neoplasia, most of these patients when investigated by prostate biopsy present BPH. Therefore, unnecessary prostate biopsies are regularly performed and they are associated with complications such as prostatitis, abscess, sepsis and even death. The percentage of free PSA (%PSA) and density (DPSA) were introduced, aiming to increase CaP detection (sensibility) and decrease the number of unnecessary biopsies (specifity). However the utilization of these tools separately, produced unsatisfactory results. Mathematical models with logistic regression with multiple variables (MRLM) and artificial neural network (RNN) present better results, nonetheless, the complexity of these calculations makes its clinical practical applicability limited. Considering the premise that the lower the percentage of the PSA and higher the PSA density greater the probability of the patient of having cancer, the objective of this study was to evaluate whether a new index (NI), obtained by dividing the value of the PSAD by the % PSA, is superior of PSA, %PSA, MRLM and DPSA for detection of CaP. Method: Study of evaluation of a diagnostic test utilizing data obtained from databases of three prospective studies, performed between 2002 and 2009 at Hospital Universitário Regional do Norte do Paraná, Hospital do Câncer de Londrina and five private practice clinics in Londrina, Paraná, which included 709 men. From this database the following variables were extracted: age, description of the digital rectal examination, total PSA, free PSA, prostate volume, %PSAL, DPSA and the result of the prostate biopsy (CaP or BPH). From these 709 men, 466 (166 with CaP and 304 with BPH) had PSA levels between 2.5 and 20 ng/ml and, simultaneously all variables mentioned above were available in their charts. The capacity of this NI to improve CaP detection was evaluated by univariate and multivariate analysis and also by a ROC curve. Results: The NI demonstrated an accuracy of 76.9% which was superior to the PSA(57.8%), %PSA(71.2%) and DPSA(73,5%) in discriminating between CaP and BPH, when PSA was between 2,5 and 20 ng/ml, increasing the detection of CaP e decreasing the number of unnecessary biopsies. The NI showed an accuracy similar (p=0, 2036) to a MRLM (78, 6%). For a sensibility of 95% for the detection of CaP, the specificity (avoided biopsies) of the PSA, %PSAL, DPSA, NI and MRLM were 8,22%, 18,42%, 20,07%, 20,39% and 26,9%, respectively. Conclusion: The NI warranted a better discrimination between CaP and BPH than isolated PSA, %PSA and DPSA. Also, presented accuracy similar to MRLM in patients with PSA between 2,5 and 20 ng/ml.

APA, Harvard, Vancouver, ISO, and other styles

5

Melo, Melissa Ely. "Pagamento por serviços ambientais (PSA)." reponame:Repositório Institucional da UFSC, 2016. https://repositorio.ufsc.br/xmlui/handle/123456789/171710.

Full text

Abstract:

Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Jurídicas, Programa de Pós-Graduação em Direito, Florianópolis, 2016. Made available in DSpace on 2016-12-20T03:14:40Z (GMT). No. of bitstreams: 1 342722.pdf: 3656107 bytes, checksum: 8ae370a280d542d890e80ab0f6caedd7 (MD5) Previous issue date: 2016 O objetivo geral da presente Tese é verificar a (in)adequação do instrumento econômico, Pagamento por Serviços Ambientais (PSA), para garantir a proteção dos serviços ecossistêmicos no contexto da crise ambiental. Esta última concebida enquanto questão social, pois marcada pela tensão entre os seres humanos e a apropriação dos recursos naturais. Também percebida enquanto crise do conhecimento, diretamente relacionado com a proliferação da problemática ambiental e incapaz de lhe oferecer solução adequada. No intuito de responder à pergunta fundante: ?O PSA é um instrumento adequado à proteção dos serviços ecossistêmicos no contexto da crise ambiental?? elaborou-se pesquisa bibliográfica e documental com fontes primárias legislativas e estudos acerca do uso real do objeto, buscando-se a compreensão do mundo teórico e da práxis, permitindo conhecer as contradições existentes entre eles. Os objetivos específicos do trabalho foram os seguintes: a) Estudar o processo de transformação do conceito de riqueza dentro do pensamento econômico, a partir da crise ambiental e da marginalização da natureza; b) Investigar as estratégias de internalização das externalidades negativas concebidas pela Economia Ambiental e recepcionadas pelo Direito, diante dos limites oferecidos pela Lei da Entropia; c) Pesquisar as dificuldades conceituais que permeiam os serviços ecossistêmicos e as suas metodologias tradicionais de valoração, confrontando a possibilidade de construção de nova abordagem em termos de valoração de serviços ecossistêmicos, com base na Economia Ecológica; d) Analisar os fundamentos jurídicos, as distintas perspectivas conceituais e as tipologias do Pagamento por Serviços Ambientais (PSA); e) Examinar a experiência de implementação do Pagamento por Serviços Ambientais (PSA) na Costa Rica e no Brasil, delineando perspectivas futuras do instrumento no contexto brasileiro. Cada qual correspondendo a um dos capítulos que ordenaram o tema. A pesquisa confirmou a sua hipótese no sentido de entender pela inadequação do PSA à proteção dos serviços ecossistêmicos no contexto da crise ambiental. Assinalou-se, no entanto, que a Economia Ecológica pode trazer algumas perspectivas no escopo de pensar-se nova concepção para o instrumento, bem como distinta abordagem para a valoração ecossistêmica. Abstract : The main objective of this thesis is to verify the (in)adequacy of the economic instrument, Payment for Environmental Services (PES) to ensure the protection of ecosystem services in the context of the environmental crisis. The latter conceived as a social issue, marked by the tension between humans and the appropriation of natural resources. It is also perceived as a crisis of knowledge, directly related to the proliferation of environmental problems and unable to offer an adequate solution. In order to answer the founding question: "Is the PES an appropriate instrument for the protection of ecosystem services in the context of the environmental crisis?", it was elaborated a bibliographical and a documental research with legislative primary sources and studies about the actual use of the object, looking for understanding of the theoretical world and the praxis, allowing to know the contradictions between them. The specific objectives were as follows: a) To study the process of transformation of the concept of wealth within the economic thought, from the environmental crisis and marginalization of nature; b) To investigate the internalization of negative external strategies designed by the Environmental Economics and received by the law, on the limits offered by the Law of Entropy; c) To find the conceptual difficulties that permeate the ecosystem services and their traditional evaluation methods, facing the possibility of a new approach for the construction in terms of evaluation of ecosystem services, based on Ecological Economics; d) To analyze the legal basis, the different conceptual perspectives and the types of Payment for Environmental Services (PES); e) To scan the implementation experience of Payment for Environmental Services (PES) in Costa Rica and Brazil, outlining the future prospects of this instrument in the Brazilian context. Each of them corresponding to one of the chapters that ordered the issue. The survey confirmed its hypothesis in order to understand the inadequacy of PES for the protection of ecosystem services in the context of the environmental crisis. It was noted, however, that the Ecological Economics may bring some support in the scope of thinking up new design for the instrument as well as distinctive approach to evaluating ecosystem.

APA, Harvard, Vancouver, ISO, and other styles

6

Lee, Ji Hyun. "Development of a Tool to Assist the Nuclear Power Plant Operator in Declaring a State of Emergency Based on the Use of Dynamic Event Trees and Deep Learning Tools." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543069550674204.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Anderle, Franz. "Phosphor-modifizierte Katalysatoren zur PSA-Herstellung." Diss., lmu, 2001. http://nbn-resolving.de/urn:nbn:de:bvb:19-1858.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

KOPAYGORODSKY, EUGENE M. "MATHEMATICAL MODEL OF ULTRA-RAPID PSA." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1002135981.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Mosca, Alessandra. "Structured zeolite adsorbents for PSA applications /." Luleå : Luleå University of Technology, 2009. http://pure.ltu.se/ws/fbspretrieve/3333675.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Moran, Aaron A. "A PSA Process for an Oxygen Concentrator." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1407928173.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Hájek, Martin. "ERP systémy pro terciární sektor ekonomiky - PSA." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-3857.

Full text

Abstract:

The main goal of this thesis is to introduce philosophy of PSA (Professional Services Automation) solutions, their benefits, structure and possible future and to describe, why and how were PSA systems developed. Inasmuch as PSA systems originally evolved from ERP systems and their current progress is very similar to the late progress of ERPs, I decided to focus my analyses on ERP systems and to use the relevant conclusions on PSA solutions. The opening chapter of the thesis (chapter 3) introduces and describes philosophy and history of ERP systems, chapter 4 then describes PSA solutions. The fifth part is addressed to the current ERP market, from which a picture of future PSA market can be derived. Practical part 6, which I consider as the primary contribution of this thesis, analyzes some dimensions of PSA in the light of future evolution of this kind of solution. It also defines some factors, that may help to increase positive effects of PSA solutions to service-oriented companies. The thesis is then closed with an example of a real PSA implementation on an engineering company (chapter 7).

APA, Harvard, Vancouver, ISO, and other styles

12

Hamborg, Kristin [Verfasser]. "Das freie prozentuale PSA und die PSA-Dichte als prognostische Marker des Prostatakarzinoms : Analyse in 1333 Fällen / Kristin Hamborg." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1035638452/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Cueva, Chonlon Francisco Iván. "Determinación anatomopatológica de cáncer de próstata en adenomectomías prostáticas. Hospital Nacional Hipólito Unanue - 2010." Bachelor's thesis, Universidad Ricardo Palma, 2010. http://cybertesis.urp.edu.pe/handle/urp/220.

Full text

Abstract:

PROBLEMA: ¿Cuál será la frecuencia de cáncer de próstata (CPI), de muestras aparentes de Hiperplasia Prostática Benigna (HPB) obtenidas por adenomectomías prostáticas (APRP)? OBJETIVOS: Determinar el estadio mediante la escala de Gleason del cáncer de próstata. Correlacionar el cáncer incidental con el PSA, la densidad de PSA, PSA libre y la velocidad del PSA. Correlacionar el CPl con la edad y el antecedente familiar de cáncer de próstata (CaP). MATERIAL Y MÉTODOS: Estudio descriptivo retrospectivo. Muestra: 1587 pacientes sometidos a APRP con diagnóstico de HPB previo a la cirugía. Criterios de Inclusión: Pacientes del Hospital Hipólito Unanue –Lima-Perú-– servicio de Urología, periodo Enero 2000 - Diciembre 2005, con diagnóstico previo a la cirugía de HPB, sin diagnóstico de cáncer de próstata (CaP) (PSA<4ng/ml y tacto rectal- fibroelastica, no nódulos). RESULTADOS: Datos de Enero del 2000 - Diciembre del 2005. Se operaron 1159 pacientes (73%) por APRP, y 428 pac. (27%) por Resección Transuretral Prostática (RTU). Hallándose 64 (4%) pac. con CPI con PSA en 8 pacientes (12.5 %) en PSA 0-2 ng/ml y 35 pac. (54.7 %) en 2.1-4 ng/ml. La velocidad de PSA, en el grupo con CPI: 44 (68.7%) pac. Que estuvieron en rango normal y 6 (9.4%) en el rango de 0.76-0.85 ng/ml. Sus edades estuvieron en el rango de edad entre 71 – 80 años a más con 50 pac. (78.1%). Además 11 pac. (17.2%) sin familiares con CaP y 49 pac. (76.6 %) con por lo menos un familiar con CaP y aún mas se encontró 4 pac. (6.25%) que tuvieron 2 o más familiares con el antecedente de CaP. Se halló un Volumen prostático en 20 pac. (31.3 %) entre 31-60 gr. y luego en 26 pac. (40.6 %) en el grupo de 61-80 gr. Presenta en el grupo de 81-100 gr. con 18 pac. (28.1%). y luego disminuye marcadamente en el grupo de 101 a más hasta 0 pacientes. Se halló 62 pacientes (96.7%) con adenocarcinoma de próstata y 2 pac. (3.3%) con cáncer de tipo transicional. 23 pacientes (37%) presentan un valor de Gleason bajo, 20 pacientes (31%) con Gleason entre 3-4; si observamos en general menos de Gleason 7 son 53 pacientes (82.8%). Con estadío T1a en 44 pac. (68.8 %), mientras que T1b eran solo 20 pac. (31.2%). CONCLUSIONES: De 1587 pac. operados, 1159 pac. (73%) se operaron por APRP y 428 pac. (27%) por RTU. Hallándose 64 (4%) pac. con CPI frecuentemente del tipo adenocarcinoma de próstata, con Escala de Gleason de bajo grado, (menos de 7). Siendo del tipo T1a la más común. El PSA está en el límite superior de su rango normal en los pacientes con CPI. No hay asociación entre el CPI Y la velocidad de PSA, índice del PSA, edad, tacto rectal, volumen prostático. Hay correlación entre el antecedente familiar y el CPI.

APA, Harvard, Vancouver, ISO, and other styles

14

Carvalho, José Luís Pinto da Silva de. "Diagnóstico de carcinoma da próstata valor do PSA." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/21148.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Špatenková, Dana. "Vývojová a traumatická onemocnění kolenního kloubu u psa." Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-257750.

Full text

Abstract:

Patellar luxation is a condition subject to heredity. It varies in gravity depending on its clinical grade and on the duration of luxation. Patellar luxation may be medial which is more common type and lateral which is less common. Often the only way to sustain a comfort of a dog patient and its normal use of a hind limb is surgical management. Considering a hereditary and congenital aspect of patellar luxation we see that it is an important breeding problem and some measures should be taken to stop its spread in breeds. The cranial cruciate ligament rupture is mostly traumatic in origin and affects especially large and giant breed dogs although all breeds may be affected. In the lower percentage of cases there is possible a degenerative origin of the disease. There is a higher prevalence of the disease in older and less active dogs. After a diagnosis of a LCC rupture surgical intervention should be implied and performed as soon as possible to put an end to the progress of arthrotic changes and to sustain the patients comfort. This master thesis was also concerned with original research examining 23 dogs with patellar luxation or LCC rupture, two dogs of these afflicted with both. Hypotheses of the thesis introduction have been mostly confirmed, LCC rupture afflicted especially overweight or obese individuals (56%), predominant affliction of females has been also confirmed (56%), partly also increased affliction of neutered animals (25% females, 6% males). Medial patellar luxation is distinctively more common than lateral one, the hypothesis has been confirmed, medial patellar luxation afflicted 100% of the dogs. Medial patellar luxation affects mostly small and miniature breeds, the hypothesis has been confirmed, all examined dogs were of small or miniature breed (100%).

APA, Harvard, Vancouver, ISO, and other styles

16

Carvalho, José Luís Pinto da Silva de. "Diagnóstico de carcinoma da próstata valor do PSA." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/21148.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Fröhner, Michael, Oliver W. Hakenberg, Rainer Koch, Uta Schmidt, Axel Meye, and Manfred P. Wirth. "Comparison of the Clinical Value of Complexed PSA and Total PSA in the Discrimination between Benign Prostatic Hyperplasia and Prostate Cancer." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133807.

Full text

Abstract:

Background: To compare the clinical value of the measurement of complex and total PSA in the discrimination between benign prostatic hyperplasia (BPH) and prostate cancer. Methods: In serum samples collected from 166 men with histopathologically proven clinically localized prostate cancer and of 97 men with BPH, total prostate-specific antigen (PSA), complexed PSA and the free to total PSA ratio were determined. The statistical analysis was done by the comparison of the receiver operator characteristic (ROC) curves. Results: The areas under the ROC curves were 0.776 for total PSA, 0.799 for complexed PSA (total PSA vs. cPSA: p < 0.0001) and 0.812 for the free to total PSA ratio. With a cut-off of 3.0 ng/ml for complexed PSA, the sensitivity was 90%, the specificity 58%, the positive and the negative predictive values 79 and 78%, respectively. With a cut-off of 4.0 ng/ml for total PSA, the sensitivity was 87%, the specificity 59%, the positive and the negative predictive values were 78 and 72%, respectively. Conclusions: There was a statistically significant advantage for complexed PSA compared to total PSA in the discrimination between BPH and prostate cancer. The difference was, however, small and its clinical relevance is questionable Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich

APA, Harvard, Vancouver, ISO, and other styles

18

Fröhner, Michael, Oliver W. Hakenberg, Rainer Koch, Uta Schmidt, Axel Meye, and Manfred P. Wirth. "Comparison of the Clinical Value of Complexed PSA and Total PSA in the Discrimination between Benign Prostatic Hyperplasia and Prostate Cancer." Karger, 2006. https://tud.qucosa.de/id/qucosa%3A27537.

Full text

Abstract:

Background: To compare the clinical value of the measurement of complex and total PSA in the discrimination between benign prostatic hyperplasia (BPH) and prostate cancer. Methods: In serum samples collected from 166 men with histopathologically proven clinically localized prostate cancer and of 97 men with BPH, total prostate-specific antigen (PSA), complexed PSA and the free to total PSA ratio were determined. The statistical analysis was done by the comparison of the receiver operator characteristic (ROC) curves. Results: The areas under the ROC curves were 0.776 for total PSA, 0.799 for complexed PSA (total PSA vs. cPSA: p < 0.0001) and 0.812 for the free to total PSA ratio. With a cut-off of 3.0 ng/ml for complexed PSA, the sensitivity was 90%, the specificity 58%, the positive and the negative predictive values 79 and 78%, respectively. With a cut-off of 4.0 ng/ml for total PSA, the sensitivity was 87%, the specificity 59%, the positive and the negative predictive values were 78 and 72%, respectively. Conclusions: There was a statistically significant advantage for complexed PSA compared to total PSA in the discrimination between BPH and prostate cancer. The difference was, however, small and its clinical relevance is questionable. Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

APA, Harvard, Vancouver, ISO, and other styles

19

Dias, Clarissa Lombardi. "Preparação e caracterização de nanopartículas de molibdatos de terras raras para detecção do antígeno específico da próstata (PSA)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-13062014-092729/.

Full text

Abstract:

O interesse em utilizar terras raras para investigar propriedades e funções de sistemas bioquímicos tanto quanto de determinar substâncias biológicas tem crescido em diferentes áreas, incluindo biomarcadores em imunologia (fluoroimunoensaios). Atualmente, o uso de terras raras no diagnóstico de diversas doenças tem se tornado muito importante com o desenvolvimento de kits de diagnóstico. Como característica principal, as terras raras podem apresentar longo tempo de vida, fotoestabilidade e bandas de emissão finas e bem definidas na região do visível, demonstrando vantagens únicas quando comparadas a outras espécies luminescentes. O presente trabalho teve como objetivo sintetizar molibdatos de terras raras pelo método de coprecipitação, assim como caracterizá-los através de técnicas como: difração de raios X, espectroscopia do infravermelho, análise termogravimétrica, microscopia eletrônica de varredura, microscopia eletrônica de transmissão e estudos de luminescência. Nesse trabalho foram desenvolvidos três diferentes estudos de síntese: a influência da variação da velocidade do dispersor no momento da precipitação; a influência do tratamento térmico na estrutura, morfologia e propriedades luminescentes; e a influência da concentração do íon dopante nas propriedades estruturais e espectroscópicas. Outro passo importante desse trabalho foi o de aminofuncionalizar as nanopartículas utilizando um organosilano (APTES) para recobrir e estabelecer pontos para que essas partículas pudessem se ligar a espécies biológicas. Foi comprovado pelos resultados das caracterizações que esse processo foi eficiente e a incorporação da sílica foi bem sucedida. O Antígeno Específico da Próstata (PSA) foi então ligado às nanopartículas funcionalizadas para possibilitar o diagnóstico de câncer de próstata através de fluoroimunoensaios e dessa forma, níveis de detecção foram estabelecidos. The interest in using rare earths to investigate the properties and functions of biochemical systems as well as to determinate biological substances has increased in several fields, including biomarkers in immunology (fluoroimmunoassays). Nowadays the use of lanthanides in the diagnosis of various diseases have become more important through the development of commercial diagnostic kits. As main feature, these rare earths can show a long lifetime, photostability and emission bands of atomic like behavior and well defined, in the visible region, demonstrating unique advantages when compared to other luminescent species. The present work had as its goal to synthesize rare earth molybdates by the co-precipitation method as well as to characterize these materials by X-ray diffraction, near infrared spectroscopy, thermogravimetric analysis, scanning electronic microscopy, transmission electronic microscopy and luminescent studies. In this work, three different studied were developed: the influence of the vortex speed variation during co-precipitation in the structure of the final product, morphology and luminescence properties; the influence of the annealing temperature also in the structure, morphology and luminescence properties; and the influence of concentration of the doping in the luminescence properties. Another important step of this work was the functionalization of nanoparticles using an organosilane (APTES) to coat and establish points for binding the particles to biological species. It was proved that this process was very efficient by the characterization results and the silica incorporation was well succeeded. Specific prostatic cancer (PSA) was then linked to the functionalized nanoparticles to diagnostic prostatic cancer by fluoroimmunoassay and levels for detection were established.

APA, Harvard, Vancouver, ISO, and other styles

20

Moreira, Alexandre Marques. "Separação adsortiva de misturas etanol-água por processo PSA." Universidade Federal de São Carlos, 2005. https://repositorio.ufscar.br/handle/ufscar/4168.

Full text

Abstract:

Made available in DSpace on 2016-06-02T19:56:59Z (GMT). No. of bitstreams: 1 DissAMM.pdf: 1945898 bytes, checksum: afb882ff1ea5d0b744547e87dfa2e263 (MD5) Previous issue date: 2005-03-02 Financiadora de Estudos e Projetos The ethanol is one of the most well-known and diffused fuels sources in nowadays, therefore the domain of its technology has a great importance to the producer countries. Beyond it is in general, lesser expensive than the major part of the petrochemical fuels, the ethanol has its origin in the renewable sources that becomes Brazil in a world power on its production. From these facts the present work consists on the application of the PSA (Pressuring Swing Adsorption) process on the ethanol purification, from ethanol-water mixtures with compositions that simulate ethanol concentrations of the final steps of distillation process. To get this ethanol purification it was used the zeolite 3A as adsorbent, which adsorbed the water of the mixtures in a pressured bed. The PSA process were composed by four steps: The first was the adsorption bed pressurization, at high temperature, with a given ethanol-water mixture; the second was the residence of the fed mixture for a given time in the bed to recover the ethanol; the third was the depressurisation of the bed to the ambient pressure, and the fourth was the regeneration of the adsorbent by vacuum, to recover the water adsorbed. The process variables studied in this work were adsorption pressure, adsorption time and initial concentration, being evaluated their influences on the response variables fluid phase enrichment, ethanol recover and process productivity, were studied, through a factorial planning. These influences were described by polynomial models, in which were applied the statistical tests F and R2, to analyse the quality of the obtained adjustments. The obtained models were validated by extra experiments done out of the factorial planning. The influences of the process variables over the response variables were analysed through response surfaces generated by the obtained polynomial models. The response variables were individually optimized with the using of search programs, which sought the best results over the polynomial models and the process variable ranges. The individual optimum results of the response variables were found, at the same way, the values of the process variables that produced these results. The response variables were also optimized together simultaneously. To obtain these optimizations search programs, with the same logic of the used in the individual optimization, were used with the multiresponse method, which made possible the obtainment of the optimum values of response variable arrangements in pairs and all of these together simultaneously. These optimum values to these arrangements were obtained, at the same way that the process variable values, which correspond to these optimizations. The enrichment obtained results showed high values and low variations with the increase of the adsorption time. At the same way, the adsorption pressure influences the enrichment significantly only with low values of the initial concentration and adsorption time. The enrichment had also an increase of its value and a decrease of its variation, with the increase of the initial ethanol concentration. The ethanol recover showed without significantly influence with the variations of the adsorption time and the adsorption pressure, however had an increase with the increase of the initial concentration. The productivity profiles showed that they were influenced by the three process variables. The increase of the productivity was detected with the increase of the initial concentration and the increase of the adsorption pressure. The productivity decreased with the increase of the adsorption pressure. The obtained results to the simultaneous optimizations showed that the productivity had a predominant influence over the other response variables optimized with these. At the same way, the recover values were not influenced by the optimization of the others response variables. Also it was seen that the enrichment optimization impaired the productivity results, in spite of the reverse fact had not been verified. To illustrate the generated results of the optimizations, the next values were obtained to the optimization of the three response variables simultaneously: 94.7% to the fluid phase enrichment, 82.5% to the ethanol recover and 5.14g.g-1.h-1 to the process productivity, with the values of the process variables of 10 bar to the adsorption pressure, 90% to the initial ethanol concentration and 2.0 minutes to the adsorption time. O etanol é uma das fontes combustíveis mais conhecidas e difundidas na atualidade, sendo então de grande importância o domínio de sua tecnologia para os países produtores. Além de ser um combustível, em geral, de custo inferior à maioria dos derivados petroquímicos, o etanol é proveniente de fontes totalmente renováveis, tornando o Brasil uma potência mundial na sua produção. Desta forma o presente trabalho trata do estudo da aplicação do processo PSA (Pressuring Swing Adsorption) na purificação do etanol a partir de misturas etanolágua com composições simulando às encontradas no final do processo de destilação convencional. Para isso foi utilizado o adsorvente comercial zeólita 3A, promovendo a adsorção da água em um leito pressurizado. O processo PSA empregado consistia basicamente de quatro etapas: A primeira se dava com a pressurização, a alta temperatura, do leito adsorvente com uma determinada mistura de etanol-água; a segunda consistia na permanência da mistura no leito durante um tempo pré-estabelecido; a terceira consistia na despressurização do leito até a pressão ambiente para a retirada do etanol, e a quarta se dava pela regeneração do adsorvente através de vácuo aplicado ao leito, para a retirada da água. As variáveis de processo estudadas neste trabalho foram pressão de adsorção, concentração inicial de alimentação e tempo de adsorção, sendo avaliadas suas influencias sobre as variáveis resposta enriquecimento da fase fluida, recuperação de etanol e produtividade do sistema, a partir de experimentos elaborados através de um planejamento fatorial. Estas influências foram descritas por modelos polinomiais, nos quais foram aplicados os testes de avaliação estatística F e R2, a fim de analisar a qualidade dos ajustes obtidos, além de terem sido obtidos pontos experimentais extras utilizados para a validação dos modelos obtidos. As influências das variáveis de processo sobre as variáveis resposta foram visualizadas através de superfícies resposta geradas a partir dos modelos polinomiais obtidos. As variáveis resposta forma otimizadas individualmente a partir de programas de busca, os quais varriam as faixas de valores adotadas pelas variáveis de processo estudadas, sendo portanto encontrados os valores ótimos individuais de cada variável resposta, assim como os valores das variáveis de processo necessários para a obtenção destes ótimos. As variáveis resposta também foram otimizadas em conjunto, simultaneamente. Para isto também foram utilizados programas de busca, aplicando-se o método de otimização multiresposta, o qual possibilitava a obtenção de valores ótimos combinando-se as variáveis resposta em pares e todas simultaneamente. Estes valores ótimos foram obtidos, assim como os valores das variáveis de processo correspondentes a estas otimizações. Os resultados obtidos para o enriquecimento da fase fluida mostraram um maior valor e uma menor variação deste com o aumento no tempo de adsorção; assim como a existência de variação significativa deste com a pressão de adsorção apenas para valores baixos de concentração inicial e tempo de adsorção. O enriquecimento teve também um aumento em seu valor, acompanhado de uma diminuição de variação com o aumento da concentração inicial de etanol. A recuperação de etanol mostrou-se não ser influenciada pelo tempo de adsorção e pela pressão de adsorção, havendo um aumento desta variável resposta apenas com o aumento da concentração inicial de etanol. Os comportamentos da produtividade se mostraram influenciáveis por todas as variáveis de processo. Houve aumento da produtividade com o aumento da concentração inicial de etanol e com o aumento da pressão de adsorção, havendo também diminuição da produtividade com o aumento do tempo de adsorção. Os resultados obtidos nas otimizações simultâneas mostraram que a produtividade teve influencia predominante frente às outras variáveis em combinação com esta, assim como os valores da recuperação não foram influenciados pelas otimizações das outras variáveis. Foi constatado também que a otimização do enriquecimento comprometeu os resultados de produtividade, onde o contrário não foi verificado. Como exemplo dos resultados gerados pelas otimizações, foram obtidos os seguintes valores para a otimização de todas as variáveis resposta em conjunto: 94,7% de enriquecimento, 82,5% de recuperação e 5,14g.g-1.h-1 de produtividade, com a combinação das variáveis de processo de 10 bar para a pressão de adsorção, 90% para a concentração inicial de etanol e 2,0 minutos para o tempo de adsorção.

APA, Harvard, Vancouver, ISO, and other styles

21

Stene, Henrik Sørskår, and Ole Marius Moen. "Power Plant with CO2 Capture based on PSA Cycle." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for energi- og prosessteknikk, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26240.

Full text

Abstract:

Two coal-fired power plants with CO2 capture by Pressure Swing Adsorption (PSA) havebeen modeled and simulated. The two power plants considered were IntegratedGasification Combined Cycle (IGCC) and conventional Pulverized Coal Combustion (PCC). Amathematical model of the PSA process for each of the power plants was developed and thegoal was to evaluate the feasibility of PSA as a technology for decarbonisation. Theperformance with CO2 capture by PSA was compared to a reference plant without CO2capture and to a power plant with CO2 capture by absorption, which is considered as thebenchmark technology. The size and number of the PSA columns were estimated todetermine the footprint.For the PCC power plant, the PSA model was a two-stage process consisting of a front and a tail stage. Two-stages mean that it consisted of two consecutive PSA processes. The front stage was a three-bed, five-step Skarstrom process with rinse. The tail stage was a two-bed, five-step Skarstrom process with pressure equalization. Zeolite 5A was used as adsorbent. For a specified capture rate of 90.0 %, the process achieved a purity of 96.4 % and a specific power consumption of 1.3 MJ/kgCO2. The net plant efficiency dropped 16.6 percentage points from 45.3 % to 28.7 % when introducing CO2 capture by PSA. In comparison, the PCC plant using absorption achieved a net plant efficiency of 33.4 %. The results indicate that the current state of the art PSA technology for decarbonisation as an alternative to absorption is not realistic for PCC power plants.For the IGCC power plant, the PSA model was a seven-bed, twelve-step Skarstromconfiguration with four pressure equalization steps using activated carbon as adsorbent. The process achieved a purity of 87.8 % and a capture rate of 86.3 % with negligible power consumption. The PSA process did not satisfy the performance targets of 90 % recovery and 95.5 % purity, and due to the low purity it is uncertain whether or not transport and storage of CO2 is at all feasible. The net plant efficiency dropped 12.5 percentage points from 47.3 % to 34.8 %. In comparison the IGCC plant with absorption achieved a net plant efficiency of 36.4 %. The results showed that PSA as a capture technology for IGCC power plants could not perform quite as well as absorption. However, PSA as a capture technology could have a potential if the purity could be increased, and is therefore more promising than PSA for PCC power plants.

APA, Harvard, Vancouver, ISO, and other styles

22

Patel, Krupal. "Numerical modelling of fibrillation and cavitation in PSA tapes." Electronic Thesis or Diss., Université Paris sciences et lettres, 2022. http://www.theses.fr/2022UPSLS039.

Full text

Abstract:

Dans les bandes PSA (Adhésifs sensibles à la pression), la rupture d’adhésion est accompagnée de cavitation et de fibrillation. Au niveau microscopique, les deux phénomènes impliquent une grande déformation. Comme le matériau de cet adhésif sensible à la pression est viscoélastique, cette grande déformation conduit à la dissipation de l’énergie. Cette dissipation d’énergie est de plusieurs ordres de grandeur supérieure au travail thermodynamique d’adhésion entre substrat et adhésif. Ces mécanismes de rupture d’adhérence par cavitation et fibrillation vont au-delà du cadre de la mécanique linéaire standard de rupture élastique. Par conséquent, nous utilisons des modèles de matériaux hyper-élastiques tels que Arruda-Boyce et Yeoh qui peuvent tenir compte de l’écrouissage et aussi de la nature viscoélastique de ces matériaux d’une manière élastique efficace en considérant la dépendance au taux de déformation. Ce type de mise en œuvre de modèles de matériaux dans la modélisation numérique de la cavitation et de la fibrillation conduit à aider à comprendre l’énergie de pelage total.Dans cette étude, nous modélisons numériquement le mono-fibrille de différents rapports d’aspect en utilisant la méthode des éléments finis (FEM). La faible réponse de déformation des simulations FEM est comparée au contact plat du poinçon avec le demi-espace enduit. Pour implémenter le problème de contact de poinçon plat, nous utilisons la méthode Boundary Element (BEM). En dehors de cela, nous utilisons certaines méthodes analytiques simplifiées telles que le test Poker-chip pour la comparaison. La simulation confirme que la force require pour tirer les fibrilles d’un film adhésif plat est plus grande que la force require pour étendre uniaxialement des brins indépendants hypothétiques de l’adhésif. Nous étudions également le décollement du fibril pour nos bandes PSA sur mesure de la société 3M et donnons la loi de puissance pour la force et le déplacement au décollement du substrat de verre à une vitesse de peeling particulière. De plus, nous étudions l’effet du glissement et de la compressibilité sur le décollement fibrillaire. Nous vérifions également l’effet de l’écrouissage sur la cavitation dans le milieu infini par méthode analytique. Ensuite, nous montrons la simulation axisymétrique en expansion et la cavité confinée et comment elle se compare aux simulations du fibril.Comme il est difficile de contrôler les paramètres tels que le rapport d’aspect et la distance interfibrillaire des fibrilles dans les expériences de peeling sur le substrat homogène, nous avons utilisé des données expérimentales de pelage de substrat modélisé pour comparer nos résultats de simulation. Cette comparaison est essentielle pour avoir un aperçu de la conception future du motif qui peut améliorer l’adhésion In PSA (Pressure Sensitive Adhesives) tapes, adhesion rupture is accompanied by cavitation and fibrillation. At the microscopic level, both phenomena involve large deformation. As the material of this pressure-sensitive adhesive is visco-elastic, this large deformation leads to the dissipation of energy. This dissipation of energy is several orders of magnitude higher than the thermodynamic work of adhesion between substrate and adhesive. These mechanisms of adhesion rupture by cavitation and fibrillation go beyond the framework of the standard linear elastic fracture mechanics. Hence, we employ hyper-elastic material models such as Arruda-Boyce and Yeoh which can account for strain hardening and also for the viscoelastic nature of these materials in an effective elastic manner by considering strain rate dependency. This type of implementation of material models in numerical modeling of cavitation and fibrillation leads to help in understanding the total peeling energy.In this study, we numerically model the mono-fibril of different aspect ratios using the finite-element method (FEM). The small strain response of FEM simulations is compared with the flat punch contact to coated half-space. To implement the flat punch contact problem, we use Boundary Element Method (BEM). Apart from that, we use some simplified analytical methods such as the Poker-chip test for comparison. Simulation confirms that the force to draw fibrils from a flat soft adhesive film is larger than the force to uniaxially extend hypothetical independent strands of the adhesive. We also study the fibril debonding for our custom-made PSA tapes made by 3M company and give the power law for the force and displacement at debonding from the glass substrate at a particular peeling velocity. In addition to that, we also study the effect of sliding and compressibility on fibril debonding. We also check the effect of strain hardening on cavitation in the infinite medium by analytical method. Then we demonstrate the axisymmetric simulation of expanding and confined cavity and how it compares with the fibril simulations.As it is difficult to control the parameters such as aspect ratio and interfibrillar distance of fibrils in peeling experiments on the homogeneous substrate, we used experimental peeling data of patterned substrate for comparing our simulation results. This comparison is essential to gain insight into the future design of the patterning which can improve the adhesion

APA, Harvard, Vancouver, ISO, and other styles

23

Garnique, Díaz Emilio Sebastian. "Relación de PSA libre sobre PSA total en pacientes con diagnóstico de cáncer de próstata mediante biopsia de próstata transrectal ecodirigida (2008 – 2012)." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2013. https://hdl.handle.net/20.500.12672/14622.

Full text

Abstract:

Publicación a texto completo no autorizada por el autor Determina el punto de corte de sensibilidad óptima del cociente PSAL / PSAt, para detectar CaP en pacientes tratados en el Hospital Nacional PNP Luis N. Sáenz en el periodo entre el 2008 al 2012. Estudio de tipo retrospectivo y metodología observacional, comparativa (no concurrente), analítico y descriptivo en 398 pacientes con sospecha de Cáncer de próstata quienes se les realizo biopsia de próstata transrectal eco-dirigidas en el Servicio de Urología del Hospital Nacional PNP Luis N. Sáenz, post criterios de inclusión. La ficha de datos, fue el instrumento principal de la investigación. La edad promedio fue de 61.4 años, donde la edad más frecuente fue entre 66 – 70 años (55.75%). Se diagnosticaron 61 adenocarcinoma de Próstata (15.35%), con un valor de corte por debajo de 15% de PSAL / PSAt, en 55 pacientes con CaP y menos del 10% de CaP presentaron índices de PSAL / PSAt > 20%. La curva de ROC señala decidir entre 14 y 15 como valor de corte. Se observaron 269 casos con complicaciones post biopsia 178 leves (44.70%) y 91 no leves (22.90%). El cociente PSAL/PSAt o porcentaje de PSAL incrementa la especificidad del PSA en pacientes asintomáticos y con un valor de PSA t entre 4 y 10 ng/ml. Con un punto de corte del 15%, la sensibilidad de CaP fue de 90.15%, pero con una especificidad de 22% (decreciente). El índice PSAl/PSA t, es un método útil para optimizar la indicación de biopsia y mejorar así la tasa de productividad de la misma, evitando así biopsias innecesarias. Las complicaciones del método diagnóstico por biopsia prostática transrectal ecodirigida fueron frecuentes en esta serie (67.60%), con un aumento de costo hospitalario adicional. Trabajo académico

APA, Harvard, Vancouver, ISO, and other styles

24

Adomaitis, Robertas. "Ankstyvosios diagnostikos programos poveikio sergamumui priešinės liaukos vėžiu Lietuvoje vertinimas." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120118_131143-54530.

Full text

Abstract:

Prostatos, vėžys. yra pati dažniausia ir antra pagal mirtingumą vyrų onkologinė liga Lietuvoje. Prostatos specifinio antigeno (PSA) testo naudojimas ankstyvai patikrai leidžia tikėtis šios ligos užleistumo ir mirtingumo mažėjimo. Mažos rizikos prostatos vėžio gydymas radikaliais metodais yra tapęs neatsiejamu ankstyvos patikros palydovu. Nėra žinoma ar bendros praktikos gydytojų (BPG) siūloma informuoto paciento PSA patikra realioje populiacijoje turės tokį patį poveikį kaip klinikiniuose tyrimuose. Šis tyrimas yra pirmas nacionaliniu mastu atliekamos PSA tyrimu pagrįstos patikros programos poveikio sergamumui prostatos vėžiu vertinimas. Išanalizuota organizuotos patikros skvarba populiacijoje pagal skirtingas amžiaus grupes ir BPG teikiamos paslaugos galimybės mažinant skirtingo amžiaus vyrų prostatos vėžio užleistumą. Sukurta duomenų bazė jungianti PSA patikros ir sergamumo prostatos vėžiu duomenis leidžia nagrinėti organizuotos patikros efektyvumą. Nustatyta, kad ankstyvos patikros skvarba ypač maža 50-54 metų vyrų grupėje, tačiau jau po dvejų metų BPG teikiama informavimo ir PSA patikros paslauga lėmė ne tik lokalaus, bet vietiškai išplitusio prostatos vėžio atvejų mažėjimą visoje 50–75 metų vyrų grupėje. Remiantis tyrimo rezultatais rekomenduojama naudoti papildomas informavimo priemones, įtraukiant jaunesnius nei 60 metų vyrus į ankstyvos patikros programą, bei plačiai naudoti mažos rizikos prostatos vėžio aktyvią stebėseną. Prostate cancer is most common and second deadliest tumour diagnosed in Lithuanian men. Prostate specific antigen (PSA) test in early detection of prostate cancer could result in decreased morbidity and mortality. Radical treatment of low-risk prostate emerged as an inevitable satellite of early detection. It is unknown if PSA testing offered to informed men by general practitioners (GP) could have the same results as in clinical trials. This study is the first evaluation of the nation wide prostate cancer detection program based on PSA testing. GP based early detection program is analysed according to the penetration of PSA testing in different age groups and the potential to decrease prostate cancer morbidity. The created database integrating data of PSA testing and incidence of prostate cancer permits in analysis of the effectiveness of early detection. Penetration of PSA testing was determined to be the lowest in 50-54 years men. After two years GP based PSA testing service resulted in decreased incidence of localized and locally advanced prostate cancer across 50-75 years men group. Results of the study suggest that men younger than 60 years need to be involved in early detection program by additional means of information. The active surveillance should be widely used for management of the low-risk prostate cancer.

APA, Harvard, Vancouver, ISO, and other styles

25

Hennage, John B. "Characterization of a Pressure Sensitive Adhesive (PSA) for Mechanical Design." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/35572.

Full text

Abstract:

This thesis outlines a methodology for formatting and applying stress models, collecting visco-elastic material properties, and presenting the material data for use in adhesive joint designs. There are a number of models/theories that can be applied to the design of Pressure Sensitive Adhesive (PSA) joints. Unfortunately, few design engineers are familiar with these models and the models are not formatted in a manner that can easily be applied to joint designs. By developing a format that is based on the existing knowledge of the designer and presenting them in a familiar manner the theories/models can easily be used in joint designs. This technique was demonstrated with Beam-on-Elastic Foundation, Shear Lag, and Shape Factors. Design examples successfully demonstrated the application of all of these models in the analysis and design of simple adhesive joints. The material properties of PSAs are a function of loading/displacement rate, temperature, relative humidity, and stress state. The Arcanm fixture was used to test VHB™ 4950 over a range loading and stress states including fixed load and displacement rates. Several bond widths were tested to determine the extent of the shape factor effect. A second fixture was used to determine the impact of gradient-tensile stresses on the failure strength. All of the collected data was used to generate design plots. The strength data was presented as allowable strength envelopes with respect to rate. The moduli were calculated from the load-displacement data and plotted with respect to the displacement rate. The failure strength from the fixed load and displacement data were used to transform from one loading case to the other and a plot was generated. These three plots were used in the design and analysis of several adhesive joints. The methods demonstrated in this thesis show a great deal of promises as a design tool, but there is still a large amount of work to be done. The design space for this material is much larger than what was covered by this work. Additional strength testing needs to be conducted to fully characterize the material for all key applications. The principle of time-temperature superposition, beam-on-elastic foundation, shear lag, and shape factors all need to be validated for this material. Master of Science

APA, Harvard, Vancouver, ISO, and other styles

26

Magnani, Florian. "La dimension humaine du Lean : le cas du Groupe PSA." Thesis, Paris 1, 2018. http://www.theses.fr/2018PA01E038/document.

Full text

Abstract:

Alors que la production de masse représentait le paradigme industriel dominant dans les années 80, le Toyota Production System, le système d'amélioration continue exemplifié chez Toyota, a suscité l'intérêt de nombreux chercheurs et industriels à la recherche de moyens d'améliorer la performance opérationnelle et financière des organisations. L'objectif de la thèse repose sur la caractérisation de la dimension humaine dans les systèmes de production intégrant une forte composante d'amélioration continue dans le but de la considérer lors du processus d'adoption. Pour cela, la thèse s’oriente autour de trois contributions majeures : la définition de la dimension humaine inhérente au Lean, l'évolution historique des éléments constituants cette dimension humaine et son opérationnalisation au travers du rôle des experts du Lean dans le processus d'adoption While mass production was the dominant industrial paradigm of the 1980s, the Toyota Production System, Toyota's exemplary continuous improvement system, has attracted the interest of many researchers and industry in seeking ways to improve operational and financial pe1formance of their organizations. The aim of this thesis is to characterize the human dimension in production systems including a strong component of continuous improvement in order to consider it during the adoption process. For this, the thesis focuses on three major contributions: the definition of the human dimension inherent to Lean, the historical evolution of the elements that represent this human dimension and its operationalization through the rote of Lean experts in the adoption process

APA, Harvard, Vancouver, ISO, and other styles

27

Peixoto, Hugo Rocha. "Modeling of CO2 separation in post-combustion processes by PSA." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=14096.

Full text

Abstract:

CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior Adsorption processes involving carbon dioxide (CO2) capture and sequestration have been objects of different studies. A typical problem is the separation of CO2 from fuel gases emitted in power plants in order to mitigate the global warming effects. Recently, Pressure Swing Adsorption (PSA) technology is being applied to this separation. However, design and analysis of adsorption processes are a difficult task due to the large number of parameters involved. This work studies the dynamics of this separation in activated carbons C141 and WV 1050 through commercial software Aspen Adsorption (AspenTechÂ). First, we evaluated the ability of the software reproducing experimental fixed bed data in C141 reported on literature, considering the mixture 10% of helium (carrier gas), 15% dioxide carbon and 75% nitrogen, molar basis. The results showed satisfactory resemblance to the literature. From a scale-up of the analyzed system, it was sized a PSA apparatus at 298 K operating with two columns and four steps: adsorption, depressurization, purge and repressurization (Skarstrom cycle). High-pressure step was at 3.0 bar and regeneration at 1.1 bar. Fuel gas mixture simulated was composed only of CO2 and N2; the molar fraction of the first component at the feed stream was 15%. The product stream in C141 showed purity and recovery of carbon dioxide from approximately 23% and 60% on a molar basis, respectively. The productivity was 0.72 t CO2 kg-1 year-1. Through the study of design variables such as column diameter and length, feed and purge flow rate, feed composition and step times, the product purity exceeded 30 % and the recovery bordered 75%, with maximum productivity of 1.02 t CO2 kg-1 year-1 for some process settings. The process yields in WV 1050 were 26.5 % purity, 47 % recovery and 0.53 t CO2 kg-1 year-1. Processos de adsorÃÃo envolvendo a captura e o sequestro de diÃxido de carbono (CO2) vÃm sendo objetos de diferentes estudos. Um dos problemas tÃpicos analisados Ã a separaÃÃo do CO2 a partir dos gases de queima emitidos em plantas energÃticas com o intuito de mitigar os efeitos do aquecimento global. Recentemente, a tecnologia Pressure Swing Adsorption (PSA) estÃ sendo aplicada para este tipo de separaÃÃo. Entretanto, o projeto e a anÃlise de processos de adsorÃÃo sÃo uma tarefa difÃcil devido Ã grande quantidade de parÃmetros envolvidos. Este trabalho estuda a dinÃmica dessa separaÃÃo nos carbonos ativados C141 e WV 1050 atravÃs do software comercial Aspen Adsorption da AspenTechÂ. Inicialmente, foi avaliada a capacidade do software no que diz respeito Ã reproduÃÃo de dados experimentais de leito fixo reportados na literatura, que consideram a mistura como sendo, em base molar, 10 % de hÃlio (gÃs de inerte), 15 % de diÃxido de carbono e 75 % de nitrogÃnio. Os resultados obtidos apresentaram semelhanÃa satisfatÃria aos da literatura para o sÃlido C141. A partir de um scale-up desse sistema analisado, foi dimensionada uma PSA a 298 K de duas colunas e quatro passos: adsorÃÃo, despressurizaÃÃo, purga e repressurizaÃÃo (ciclo Skarstrom). A etapa de maior pressÃo ocorre a 3,0 bar e a regeneraÃÃo a 1,1 bar. Considerou-se que o gÃs de queima Ã composto apenas por CO2 e N2, sendo a fraÃÃo molar de alimentaÃÃo do componente de interesse de 15%. Para C141, a corrente de produto apresentou pureza e recuperaÃÃo de diÃxido de carbono de aproximadamente 23 % e 60 % em base molar, respectivamente, com produtividade de 0,72 t CO2 kg-1 ano-1. AtravÃs do estudo de variÃveis de projeto como diÃmetro e comprimento da coluna, vazÃo de alimentaÃÃo e de purga, composiÃÃo de alimentaÃÃo e tempos das etapas do ciclo, a pureza do produto ultrapassou os 30 %, a recuperaÃÃo se aproximou de 75 % e a produtividade mÃxima foi de 1,02 t CO2 kg-1 ano-1 para algumas configuraÃÃes do processo. Os rendimentos para o adsorvente WV 1050 foram: pureza de 26,5 %, recuperaÃÃo de 47 % e produtividade de 0,53 t CO2 kg-1 ano-1.

APA, Harvard, Vancouver, ISO, and other styles

28

Sloat, Ronald D. "High-Resolution, Non-Contact Angular Measurement System for PSA/RSA." DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/485.

Full text

Abstract:

A non-contact angular measurement system for Pitch Static Attitude (PSA) and Roll Static Attitude (RSA) of hard disk drive sliders is designed and built. Real-time sampling at over 15 KHz is achieved with accuracy of +/- 0.05 degrees over a range of approximately 2-3 degrees. Measuring the PSA and RSA is critical for hard drive manufacturers to control and improve the quality and reliability of hard drives. Although the hard drive industry is able to measure the PSA and RSA at the subassembly level at this time, there is no system available that is able to measure PSA/RSA at the final assembly level. This project has successfully demonstrated a methodology that the PSA/RSA can be reliably measured in-situ using a laser and position sensitive detector (PSD) technology. A prototype of the measurement system has been built using simple and inexpensive equipment. This device will allow a continuous measurement between the parked position on the ramp and the loading position just off of the disk surface. The measured data can be used to verify manufacturing processes and reliability data.

APA, Harvard, Vancouver, ISO, and other styles

29

Navrátil, Petr. "Čištění bioplynu pomocí metody PSA (adsorpce za měnícího se tlaku)." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231509.

Full text

Abstract:

The topic of this master thesis is upgrading of biogas. As a mixture of gases produced during anaerobic digestion, contains methane which is highly energy valuable gas. But also other substances that we want to remove. We will present the motivation for upgrading biogas and the possibility of separation, generally the pressure swing adsorption method. The key parameter of this technique is the choice of a suitable adsorbent. This is possible based on the knowledge of adsorption processes, therefore, is also described below. The objective of this thesis is to determine the parameters of the pressure swing adsorption metod. To do this it is necessary to determine the adsorption capacity of the adsorbent, measure breakthrough curves of carbon dioxide and methane, and determine the pressure drop of solid bed, etc. As a result we can finally make a balance and evaluate the applicability in practice.

APA, Harvard, Vancouver, ISO, and other styles

30

Chalivoix, Stéphanie. "Transition photopériodique et plasticité neuronale dans l'hypothalamus ovin : aspects neuroanatomiques et fonctionnels." Thesis, Tours, 2010. http://www.theses.fr/2010TOUR4001/document.

Full text

Abstract:

Les mécanismes cellulaires activés par la mélatonine pour synchroniser l’alternance entre la saison dereproduction et l’anoestrus sont encore mal compris. Les niveaux et l’importance fonctionnelle de la plasticitéinduite par une transition photopériodique ont été étudiés dans des régions du cerveau impliquées dans lasynchronisation saisonnière de la reproduction chez les ovins. Nos résultats suggèrent qu’un changement dephotopériode seule serait capable d’induire, dans plusieurs régions hypothalamiques, des variations d’unmarqueur de la plasticité, la PSA-NCAM, qui participeraient à la régulation de la reproduction saisonnée enparticulier dans l’aire préoptique. Des populations neuronales affectées par des réarrangementsmorphologiques ont également été identifiées. La PSA-NCAM est plus présente au contact des neurones àGnRH et à β-endorphine au moment le plus opportun pour l’activité du neurone suggérant que la plasticitéaffectant ces deux populations cellulaires serait essentielle au déroulement de la reproduction saisonnée. Lesneurones à kisspeptine sont également plus nombreux chez des animaux ayant un axe gonadotrope actifsuggérant que cette population serait un des derniers éléments activés par l’augmentation de la durée desécrétion de la mélatonine.Nos travaux montrent qu’un changement de photopériode est suffisant pour induire des remaniementsmorphologiques dans des régions hypothalamiques nécessaires à la synchronisation saisonnière de lareproduction chez les ovins. Ces remaniements affectent des populations neuronales spécifiques Cellular mechanisms induced by melatonin to synchronize seasonal reproduction are still unclear. Thescale and functional significance of neuronal plasticity induced by a photoperiodic transition have been studiedin brain regions involved in the seasonal synchronization of sheep reproduction. Our results suggested that achange of photoperiod alone seems able to induce variations of PSA-NCAM, a plasticity marker, in severalhypothalamic areas that may participate to the regulation of seasonal reproduction particularly in the preopticarea. Neuronal populations affected by morphological rearrangements have been identified. PSA-NCAM waspresent in contact with GnRH and β-endorphin neurons when the neuropeptide secreted by that population isrequired for the timing of seasonal breeding activity. Kisspeptin neurons were more numerous in ewes havingan active gonadotrope axis suggesting that kisspeptine is one of the last element activated by the increase of theduration of melatonin secretion.All together, our results suggest that a change of photoperiod alone is essential to induce morphologicalreorganizations in hypothalamic regions necessary for the seasonal synchronization of sheep reproduction.Plasticity affects specific neuronal populations

APA, Harvard, Vancouver, ISO, and other styles

31

Svobodová, Markéta. "Selection of aptamers against prostate specific antigen for diagnostic and therapeutic applications." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/83492.

Full text

Abstract:

Actualmente, el antígeno prostático específico (PSA) se considera el marcador más sensible para la detección de cáncer de próstata. Hasta la fecha anticuerpos monoclonales y policlonales se han utilizado para detectar el PSA debido a su alta especificidad y sensibilidad. Sin embargo, la producción de anticuerpos es lenta y cara. En el otro lado, los aptámeros con especificidad y afinidad iguales a los de los anticuerpos podría ser una forma alternativa para la detección de PSA. El objetivo de este trabajo es la selección de aptámeros contra el PSA. Aspectos fundamentales como la caracterización de la PSA, la evaluación de las estrategias de inmovilización, la preparación de la biblioteca de oligonucleótidos y de la cadena simple de ADN (ssDNA) han sido evaluados con el fin de alcanzar el objetivo principal de esta tesis. Finalmente, la selección de aptámeros contra el PSA y su uso potencial en aplicaciones de diagnóstica y terapéutica han sido descritos. Currently, PSA is considered the most sensitive marker available for prostate cancer detection and for monitoring its progression. To date monoclonal/polyclonal antibodies have been used to detect PSA due to their high specificity and sensitivity. However, the production of antibodies is time-consuming and expensive. On the other hand aptamers with specificity and affinity equal to those of antibodies could be an alternative way for the detection of PSA. This work overviews the selection of aptamers against prostate specific antigen (PSA). Fundamental aspects such as the characterization of PSA, evaluation of immobilization strategies, the preparation of oligonucleotide library and single stranded DNA (ssDNA) have been evaluated in order to reach the main objective of this thesis. Finally, selection of DNA and RNA based aptamers against PSA and their potential use in diagnostic and therapeutic applications have been described

APA, Harvard, Vancouver, ISO, and other styles

32

Parsons, Kelli Joanne. "Spatial and temporal patterns of land-use induced sedimentation in Clear Creek Basin, Iowa." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6245.

Full text

Abstract:

This study is centered around the spatial distribution and age structure of PSA in a section of floodplain in the upper reaches of Clear Creek Watershed in east central Iowa. The study area topography, climate, soil, and pre-settlement tallgrass prairie landcover are representative of the headwaters of many Midwest watersheds, making the findings applicable in other parts of the region. Through this investigation, I aim to further understand the volume and age structure of PSA sediments deposited on the floodplain after Euroamerican settlement. This will be done through multiple methods: the collection and measurement of PSA in soil cores, visual and spatial analysis of land use and stream channel morphology, PSA volume calculations, and isotope geochemistry. Using 210Lead (Pb) and 137Cesium (Cs) isotope geochemistry to calculate age structures of the PSA will provide a more detailed, temporal resolution of physical data than erosion and deposition model predictions can generate. A detailed land use history will further facilitate the understanding of depositional processes that have occurred in the study area and region. By understanding the age structure of the sediment on the floodplain, as well as sediment volumes that are stored in floodplain headwaters, tangible connections can be made between agricultural land use and floodplain sedimentation rates and the impact (if any) assessed of potential conservation practices. This research is supported by the Intensively Managed Landscape Critical Zone Observatory (IML-CZO) of the National Science Foundation’s CZO network, which aims to understand how land use changes affect the long-term resilience of the critical zone, where water, atmosphere, ecosystems, soil, and bedrock interact.

APA, Harvard, Vancouver, ISO, and other styles

33

Parra, João Paulo Ruiz Lucio de Lima. "Desenvolvimento de sensores aptaméricos para monitoramento de biomarcadores de células cancerígenas prostáticas." Botucatu, 2019. http://hdl.handle.net/11449/181047.

Full text

Abstract:

Orientador: Valber de Albuquerque Pedrosa Resumo: Neste trabalho foram desenvolvidas metodologias para detecção de biomarcadores cancerígenos utilizando sensores aptaméricos. Aptâmeros são estruturas tridimensionais de DNA/RNA capazes de serem seletivos a alvos específicos. O uso destas sequências em plataformas eletroquímicas permite que o monitoramento do metabolismo celular se torne viável de uma forma rápida e exata. Para a caracterização das superfícies foram utilizadas as técnicas eletroquímicas. Foram utilizadas três proteínas biomarcadoras, PSA, fPSA e HK2 como modelos para os estudos. Os limites de detecção do aptasensor para PSA e fPSA obtidos foram de 1,1 ng/mL e 2,9 ng/mL, respectivamente. Ao final dos experimentos com linhagens celulares cancerígenas e controle, as correspondentes corroboraram com a classificação de risco do câncer de próstata bem como a capacidade de diferenciação por parte dos aptasensores entre os tipos celulares mais agressivos (PC-3, [PSA]: 23 ng/mL; [fPSA]: 6 ng/mL) e menos agressivos (LNCaP, [PSA]:12 ng/mL; [fPSA]: 7,8 ng/mL) em comparação aos grupos de referência (PNT-2, [PSA]: 1,95ng/mL; [fPSA]: 2,11 ng/mL). Para a HK2, foi possível detecta-lá na presença de todos os tipos celulares prostáticos de maneira qualitativa. Mestre

APA, Harvard, Vancouver, ISO, and other styles

34

Pavlenko, Maxim. "Induction of T-cell responses against PSA by plasmid DNA immunization /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-385-X/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Büker, Nicola [Verfasser]. "Die PSA-Dynamik zur Verfeinerung der Biopsieindikation beim Prostatakarzinom / Nicola Büker." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022941941/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Stopiglia, Rafael Mamprin 1973. "Correlação entre prostatite assintomatica com PSA elevado e cancer de prostata." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312207.

Full text

Abstract:

Orientadores: Ubirajara Ferreira, Wagner Eduardo Matheus Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas Made available in DSpace on 2018-08-14T02:30:40Z (GMT). No. of bitstreams: 1 Stopiglia_RafaelMamprin_M.pdf: 1039972 bytes, checksum: dbe43d140e3febb1ab34ec6ff75b33be (MD5) Previous issue date: 2009 Resumo: A prostatite assintomática é definida através da detecção laboratorial do aumento de células inflamatórias em secreções uretrais ou urina após massagem da glândula prostática e também detectada em biópsias. Esta alteração inflamatória é reconhecidamente uma causa de elevação dos níveis do PSA. Devido esta elevação também estar associada ao câncer prostático, desenvolvemos um estudo para avaliar a correlação entre prostatite assintomática com a referida doença maligna. No período de janeiro de 2006 à dezembro de 2007 foram selecionados 200 pacientes com idade variando entre 50 e 75 anos e com PSA maior de 2,5ng/ml e menor de 10ng/ml, para pesquisa de prostatite inflamatória assintomática nessa população. Desses pacientes, 98 (49%) apresentaram diagnóstico de prostatite assintomática inflamatória ou tipo IV através de exames laboratoriais com o teste de Meares-Stamey modificado (1). Em seguida, foram randomizados em 2 grupos: Grupo 1 com 49 pacientes que foram tratados com cloridrato de ciprofloxacin 500mg (antibiótico) 2 vezes ao dia por 4 semanas e grupo 2 com 49 pacientes que usaram placebo da mesma forma. No seguimento, o PSA foi dosado após o tratamento e todos os pacientes foram submetidos à biópsia transrretal da próstata. Foram excluídos do estudo pacientes com idade menor de 50, maior de 75 anos, os que recusaram a biópsia, os que apresentaram PSA maior que 10ng/ml devido à maior incidência de tumor (2) e os pacientes que não aceitaram participar do estudo após a aplicação do termo de consentimento. Como resultados, no grupo 1, dos 49 pacientes que receberam antibiótico, 26 (53,06%) apresentaram diminuição do PSA e desses, 7 (26,9%) foram diagnosticados com câncer de próstata na biópsia. Dos 49 pacientes do grupo 2 que receberam placebo, 29 (59,18%) apresentaram diminuição do PSA, sendo que 9 (31%) tiveram câncer na biópsia. Não houve diferença estatística nos grupos estudados, tanto com relação a diminuição do PSA após o tratamento (53,06% X 59,18%) (p=0,10), quanto a presença de tumor nas biópsias nesses casos (26,9% X 31%) (p=0,06). Embora não demonstrada diferença estatística comparado com placebo, foi observado taxa de 26,9% de câncer de próstata na biópsia dos pacientes que apresentaram diminuição do PSA após uso de antibiótico, os quais provavelmente não seriam diagnosticados. Como conclusão a existência de câncer de próstata em pacientes com prostatite assintomática é aproximadamente um terço, mesmo após a diminuição do PSA com tratamento antibiótico Abstract: Asymptomatic prostatitis is defined through the laboratorial detention of the increase of inflammatory cells in urethral secretions or piss after massage of the prostate gland and also detected in biopsies. This inflammatory alteration is admittedly a cause of rise of the levels of the PSA. Had this rise also to be associated to the prostate cancer, we develop a study to evaluate the correlation between asymptomatic prostatitis with the related malignant illness. In the period of January of 2006 to the December of 2007, 200 patients with age varying between 50 and 75 years and with PSA bigger of 2,5ng/ml and minor of 10ng/ml had been selected, for research of asymptomatic inflammatory prostatitis in this population. Of these patients, 98 (49%) had presented diagnosis of inflammatory asymptomatic prostatitis or type IV through laboratorial examinations with the test of modified Mears-Stamey (1). After that, they had been randomized in 2 groups: Group 1 with 49 patients who had been dealt with ciprofloxacin cloridrate 500mg (antibiotic) 2 times to the day per 4 weeks and group 2 with 49 patients who had used placebo in the same way. In the pursuing, the PSA was dosed the treatment after and all the patients had been submitted to the trans rectal biopsy of the prostate. They had been excluded from the study patient with lesser age of 50, greater of 75 years, the ones that had refused the biopsy, the ones that had presented bigger PSA that 10ng/ml due to bigger incidence of tumor (2) e the patients whom they had not accepted to after participate of the study the application of the assent term. As results, in group 1, of the 49 patients who had received antibiotic, 26 (53.06%) had presented reduction of the PSA and of these, 7 (26.9%) had been diagnosed with cancer of prostate in the biopsy. Of the 49 patients of group 2 that they had received placebo, 29 (59.18%) had presented reduction of the PSA, being that 9 (31%) had had cancer in the biopsy. It did not have difference statistics in the studied groups, as much with regard to reduction of the PSA after the treatment (53.06% X 59.18%) (p=0,10), how much the presence of tumor in the biopsies in these cases (26.9% X 31%) (p=0,06). Although not demonstrated to difference statistics compared with placebo, tax of 26,9% of cancer of prostate in the biopsy of the patients was observed who had presented reduction of the PSA after antibiotic use, which they would probably not be diagnosed. As conclusion the existence of cancer of prostate in patients with asymptomatic prostatitis is approximately one third, exactly after the reduction of the PSA with antibiotic treatment Mestrado Cirurgia Mestre em Cirurgia

APA, Harvard, Vancouver, ISO, and other styles

37

Müller, Roberto Lodeiro. "Parâmetros cinéticos do PSA em pacientes submetidos à biópsia de próstata." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/87166.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Soukupová, Sandra. "Hodnocení efektivnosti místního poplatku za psa v Praze a Středočeském kraji." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-149877.

Full text

Abstract:

The dog tax has been part of the Czech tax system for many decades. Nevertheless there are almost no studies solving the issue about efficiency and effectiveness of the dog tax. The answer to this issue is very interesting and brings conclusions that shouldn't be ignored. The empirical research has come up with conclusions that could disprove or at least minimize the opinions approving the preservation of the dog tax. The costs of the dog tax selection are much higher than the selection's costs of other taxes in the Czech Republic. The revenues from the dog tax don't even add up to 1 % of the total revenues. Due to all these facts there turns up a question whether it is necessary to collect this tax or not.

APA, Harvard, Vancouver, ISO, and other styles

39

Özgüler, Sebnem. "Die prognostische aussagekraft des freien prozentualen PSA (f-PSA/t-PSA) /." 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012946240&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Ströbel, Greta [Verfasser]. "Die PSA-Density als Parameter zur Verbesserung der Prostatakarzinomdiagnostik : Vergleich der PSA-Density mit prozentual freiem PSA und Gesamt-PSA / von Greta Ströbel." 2008. http://d-nb.info/989252841/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Wun-Chih, Lee, and 李文智. "PSA Simple Ellipsometer." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/42199536277152284302.

Full text

Abstract:

碩士 國立交通大學 光電(科學)研究所 83 A PSA photometric ellipsometer is introduced to measure the ellipsometric parameters psi and delta of a sample. If the field of the parallel(p) and perpendicular(s) to the plane of incident are equal, the change of the state of the pol- arization of reflected light are affected by the optical properties of sample. We will prove that only three radiances through equally spaced polarizer are needed for extracting the parameters. The results are improved by deducing measure- ments from the incident light that is linear polarized at -45(deg) to the plane of incident. The measued parameters psi and delta are used to calculate the refractive index for Pt, the thickness of thin film for SiO2 coating on Si. By comparing all the available sources, we find that our experimental error are less then 0.5%.

APA, Harvard, Vancouver, ISO, and other styles

42

PILZOVÁ, Jana. "Možnosti využití vodicího psa." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-52145.

Full text

Abstract:

The eyesight is one the most important human senses which supplies us with 80% - 90% of information about the surrounding world. It?s loss or a serious damage brings big and fundamental changes into life of the affected person and his surroundings. The social rehabilitation constitutes a very important vehicle for the re-integration of the visually impaired persons through it?s fundamental methods which are the re-education and making compensations for the lost sight. The compensation devices alone have a paramount importance in the lives of people with the visual impairment. At the present time, the market offers a lot of optical, non-optical or electronic gadgets for the visual compensation. The guide dog presents itself as one of the best working compensation solutions in the field of the space - orientation and movement. The first documentation about training dogs that would help the blind come from around year 1780 from a Parisian hospital for the blind. The account of the first trained guide dog come from the 80s of the 18th century; a blind Viennese Josef Reisinger himself has trained a guide dog then. The first news about training guide dogs in Czech Republic come from the years 1922 - 1924. In Czech Republic the guide dog training as a compensation help for the blind or visually impaired people has been established in 1991. This work is oriented at mapping out the possibilities of the entry of a guide dog into public buildings (restaurants, health clinics, schools, public offices etc) and it?s further use for the free-time activities from the point of view of the guide dog owners and of the public. Further, this work deals with the statistics of the number and the territorial division of guide dogs in South Bohemia between the years 2008 - 2011. While looking for the experience of the guide dog owners with their entering public buildings and organizing free time together with their dog, the individual in-depth interviews, the data from the focus groups and experiments have been used. To learn the views of the interviewees about their use of the guide dogs in public places, all the documentation obtained from the subjects who trained the guide dogs, the fact sheets from the focus groups and the individual in-depth interviews have been analysed. To learn the views of the public about the guide dogs entering public buildings and their use for their free time activities printed questionnaires had been used. This work may be used as a basis for the argumentation in the forming of the uniform conditions in the guide dog training in presenting them and in forming the proper laws for using the guide dogs by their owners. This work also shows the possibilities in use of the guide dogs in their free time.

APA, Harvard, Vancouver, ISO, and other styles

43

Juráňová, Natalie. "Dysplazie kyčelních kloubů psa." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-87655.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Putík, Miroslav. "Veřejnoprávní souvislosti vlastnictví psa." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356143.

Full text

Abstract:

A dog owner does not only have rights, but also (and mainly) a lot of obligations. One of the aims of this work was to look at different areas concerning the ownership (holding) of a dog in relation to the actual public law regulations. Particular chapters reflect possible life situations, which have (especially from a point of view of public law) an effect on coexistence with a dog and (often negative) the impact (penalties) for a dog holder. Thematic areas are addressed, for example, purchasing a dog, his vaccination and other health and life conditions, the possibility of shortening a tail or ears, the admissible conditions and methods that permit the killing of a dog or the conditions and ways to bury a dog. Further mention is made of the possibilities of travelling with a dog (and also abroad), also described are the law regulations of dog fees and the generally binding ordinances of municipalities. Deeper consideration was essential in respect of the areas concerning misdemeanours and criminal offences, which can be commited both on a dog and by a dog (incl. veterinarian demands or animal cruelty). There are follow-up chapters concerning liability for damage and compensation for damage. A part of the work is dedicated to breed specific legislation concerning breeding some (so called "fighting" or...

APA, Harvard, Vancouver, ISO, and other styles

45

Ho, Te-Chun, and 何德濬. "The Effect of Health PSA." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/45134914748676566425.

Full text

Abstract:

碩士 國立體育大學 休閒產業經營學系 102 The purpose of this study was to analyze the effects fo different advertising appeals and different message framing on public service advertising. The study adopted a 2x2 experiment design to test the main effects as well as the interaction between advertising appeals ((rational/emotional) and message framing (positive/negative) and to determine what kind of public service advertising could have better advertising effect. The result showed that the interaction among advertising appeals and message framing have synergy effect on advertising effect. When appeals was emotional appeal and message framing was positive, the advertising effectiveness was the best.

APA, Harvard, Vancouver, ISO, and other styles

46

Schwickardi-Jerrentrup, Maren [Verfasser]. "Freies PSA und PSA-Quotient in der Diagnostik des Prostatakarzinoms / vorgelegt von Maren Schwickardi-Jerrentrup." 2005. http://d-nb.info/975256327/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Teo, Chung Piaw, Jim Dai, and Rajeeva Lochana Moorthy. "On Optimizing PSA Berth Planning System." 2003. http://hdl.handle.net/1721.1/3720.

Full text

Abstract:

Competition among container ports continues to increase as the differentiation of hub ports and feeder ports progresses. Managers in many container terminals are trying to attract carriers by automating handling equipment, providing and speeding up various services, and furnishing the most current information on the flow of containers. At the same time, however, they are trying to reduce costs by utilizing resources efficiently, including human resources, berths, container yards, quay cranes, and various yard equipment. When planning berth usage, the berthing time and the exact position of each vessel at the wharf, as well as various quay side resources are usually determined in the process. Several variables must be considered, including the length overall (LOA) and arrival time of each vessel, the number of containers for discharging and loading, and the storage location of outbound/inbound containers to be loaded onto/discharged from the corresponding vessel. Furthermore, we aim to propose berthing plan that will be "robust", since the actual arrival time of each vessel can vary substantially from forecast. This is particular important for vessels from priority customers (called priority vessels hereon), who have been promised berth-on-arrival (i.e. within two hours of arriving) service guarantee in their contract with PSA. A robust plan will also helps to minimize the frequent updates (changes) to berthing plan that have repercussion in resource and sta deployment within the terminal. Thus, the problem reduces to one of finding a berthing plan, so that priority vessels can be berthed-on-arrival with high probability, and the vessels can be berthed as close to their preferred locations as possible, to reduce the cost of transporting the containers within the terminal. In this paper, we described an approach to address this problem. Singapore-MIT Alliance (SMA)

APA, Harvard, Vancouver, ISO, and other styles

48

Lee, Kan-Yan, and 李康源. "Polarizer-Sample-Analyzer (PSA) imaging ellipsometry." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/g55s4z.

Full text

Abstract:

博士 國立交通大學 光電工程系所 94 This work presents a simple three-intensity measurement technique to determine the ellipsometric parameters and the azimuth deviation of the polarizer in a polarizer-sample-analyzer (PSA) imaging ellipsometer. Since we have to improve the ellipsometric measurements by using polarizer’s azimuth at 45o and –45o, the parasitic error of the beam deviation in rotating element ellipsometry is solved by a nonuniform dirt spot on the wedge glass. We will prove that the azimuth deviation of the polarizer can be used to measure the normal direction of surface, so we can use it to measure the surface topography. In addition to measure the refractive index profile of a GRIN lens, we also measure the refractive profile and radius curvature of a Plano-convex lens by means of this imaging ellipsometric technique.

APA, Harvard, Vancouver, ISO, and other styles

49

Hoffmeisterová, Aneta. "Faktory ovlivňující aktivitu psa na stopě." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-95077.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Tůmová, Michala. "Využití psa ve zdravotně - sociální oblasti." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-305898.

Full text

Abstract:

Graduate thesis ,,Utilization of dog in health-social field" discuss animal therapy, such as zoo therapy, guide dogs, service dogs for people with handicaps. I specialize mostly on questions of guide and service dogs training, ethology, difference, dog welfare and guide and service dog acquisition process. I have presented the history of guide and service dog training, the process of the training itself as well as its positive and negative aspects. I have also presented the issue of visual or hearing hearing impairment, as well as the issue of handicapped people in general. Finally I present issue of animal comfort and needs, which could be to some extent damaged by the burden of heavy training and by improper handling and care.

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic 'PSA'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles