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1

De Souza, Mary Jane, Nicole Strock, Nancy Williams, Hang Lee, Kristen Koltun, Connie Rogers, Mario Ferruzzi, Cindy Nakatsu, and Connie Weaver. "Low Dose Daily Prunes Preserve Hip Bone Mineral Density With No Impact on Body Composition in a 12-Month Randomized Controlled Trial in Postmenopausal Women: The Prune Study." Current Developments in Nutrition 6, Supplement_1 (June 2022): 10. http://dx.doi.org/10.1093/cdn/nzac047.010.

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Abstract Objectives Dietary consumption of prunes has favorable impacts on bone health, however, more research is necessary to improve upon study designs and refine our understandings and determine whether unfavorable fat gain occurs with long-term treatment. Objectives: Evaluate the effects of prunes (50g and 100g/day) on bone mineral density (BMD) in postmenopausal women during a 12-month dietary intervention. Secondary outcomes include effects on body composition. Methods Single center, parallel arm 12-month randomized controlled trial (RCT; NCT02822378) to test effects of 50g and 100g/day prunes vs. a Control group on BMD (dual-energy X-ray absorptiometry) (every 6 months) and body composition in postmenopausal women with a BMD T-score of < 0.0 and >−3.0 at any site. Results 235 women (age 62.1 ± 5.0 yr) were randomized into Control (n = 78), 50 g Prune (n = 79), or 100 g Prune (n = 78) groups. Compliance was 90.2 ± 1.8% and 87.1 ± 2.1% in the 50 g and 100 g Prune groups. Dropout was 22%; however, the dropout rate was 41% for the 100 g Prune group compared to other groups (10% Control; 15% 50 g Prune; (p < 0.001)). A group × time interaction for total hip BMD was observed in Control vs 50 g Prune groups (p = 0.030), but not in Control vs 100 g Prune groups (p = 0.194). Prune consumption did not affect body mass in 50 g prune (p = 0.837) or 100 g prune (p = 0.121) groups compared to Control. A group × time interaction for fat mass was observed in Control vs 100 g Prune groups (p = 0.031), but not in Control vs 50 g Prune groups (p = 0.792). Conclusions A 50 g dose of daily dose of prunes can prevent loss of total hip BMD in postmenopausal women, without increased fat mass seen with the larger dose. Given that there was high compliance and retention at the 50 g dosage over 12 months, we propose that the 50 g dose represents a valuable non-pharmacological treatment strategy that can be used to preserve hip BMD in postmenopausal women, without increasing body or fat mass. Funding Sources California Prune Board
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2

Carvalho, Natália, Cricia Cavachini, and Marta Dudus. "Prune Belly Syndrome." Residência Pediátrica 8, no. 1 (April 2018): 45–47. http://dx.doi.org/10.25060/residpediatr-2018.v8n1-07.

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3

Timmons, Lisa, and Allen Shearn. "Germline Transformation Using a prune cDNA Rescues prune/Killer of prune Lethality and the prune Eye Color Phenotype in Drosophila." Genetics 144, no. 4 (December 1, 1996): 1589–600. http://dx.doi.org/10.1093/genetics/144.4.1589.

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Null mutations in the prune gene of Drosophila melanogaster result in prune eye color due to reductions in red pigment accumulation. When one copy of the awdKiller of prune mutant gene is present in a prune background, the animals die. The cause of prune/Killer of prune lethality remains unknown. The genomic region characterized for the prune locus is transcriptionally active and complex, with multiple and overlapping transcripts. Despite the transcriptional complexity of the genomic region of prune, accumulated evidence suggests that the prune locus is small and consists of a single transcription unit, since every prune allele to date exhibits both prune eye color and prune/Killer of prune lethality. A functional prune product from a single, full-length cDNA was identified in this study that can rescue both the eye phenotype and prune/Killer of prune lethality. The DNA sequences of several mutant prune alleles along with Western blot analysis of mutant proteins provide convincing evidence that prune mutations are nulls, and that the cDNA identified in this study encodes the only product of the prune locus.
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4

Bates, Jane. "Prune power." Nursing Standard 25, no. 23 (February 9, 2011): 27. http://dx.doi.org/10.7748/ns.25.23.27.s33.

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5

BARNES, THOMAS, and THOMAS BÜRGLIN. "Prune function?" Nature 355, no. 6360 (February 1992): 504–5. http://dx.doi.org/10.1038/355504b0.

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6

VENKATESH, TADMIRI R., and DAVID H. F. TENG. "Prune function?" Nature 355, no. 6360 (February 1992): 505. http://dx.doi.org/10.1038/355505a0.

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7

Buchner, Richard, Seeley Mudd, Bruce Carroll, and Mark Gilles. "Harvest Field Sizing as a Technique to Remove Undersize French Prunes." HortScience 33, no. 3 (June 1998): 452a—452. http://dx.doi.org/10.21273/hortsci.33.3.452a.

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Overall profitability is a major goal in successful prune production and a major component in any prune management system. Large prune crops in 1996 and 1997 have stimulated considerable interest in undersize fruit. Undersize prunes currently have marginal value and may represent a net loss because of costs to haul, dry, and to market order payments on low value prunes. One technique to control delivery size is to field size at harvest. Field sizing involves installing size-sorting devices on harvesters, which allow small prunes to fall out while valuable fruit is collected. Field sizing is considered a “risky” strategy because of the potential to remove prunes with economic value. During the 1997 harvest, 21 infield harvest sizing evaluations were made in prune orchards throughout Tehama county. The first evaluation occurred on 12 Aug. 1997, at the start of prune harvest. The final evaluation was done on 5 Sept. 1997, at the tail end of harvest. The objective was to sample throughout the harvest period to test field sizing under various sugar, size, and fruit pressure scenarios. The test machine was 1-inch bar sizer. Of the 21 sample dates, undersize fruit was clearly not marketable in 20 of the 21 samples. Discarded fruit averaged 133 dry count per pound. Only one sample out of 21 may have had market value at 86 dry count per pound. Although small in size, these prunes had very high sugar content contributing to their dry weight. In this evaluation, a 1-inch bar sizer did a good job of separating fruit with and without market value under the 1997 price schedule. As harvest date becomes later and soluble solids increase, the chances of sorting out marketable prunes also increases.
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Teviotdale, Beth L., Dennis M. Harper, Themis J. Michailides, and G. Steven Sibbett. "Postharvest prune rust does not lower French prune yield." California Agriculture 49, no. 1 (January 1995): 23–26. http://dx.doi.org/10.3733/ca.v049n01p23.

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9

Agarwal, Akash, Jhalak Goyal, and AlokS Nayak. "Prune belly syndrome." Indian Dermatology Online Journal 13, no. 3 (2022): 442. http://dx.doi.org/10.4103/idoj.idoj_656_20.

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10

Tononi, Giulio, and Chiara Cirelli. "Perchance to Prune." Scientific American 309, no. 2 (July 17, 2013): 34–39. http://dx.doi.org/10.1038/scientificamerican0813-34.

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11

Woods, Amanda G., and Debra H. Brandon. "Prune Belly Syndrome." Advances in Neonatal Care 7, no. 3 (June 2007): 132–43. http://dx.doi.org/10.1097/01.anc.0000278211.95767.05.

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&NA;. "Prune Belly Syndrome." Advances in Neonatal Care 7, no. 3 (June 2007): 144–45. http://dx.doi.org/10.1097/01.anc.0000278212.03392.13.

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Tagore, Koyye Ravindranath, Asok Kumar S. Ramineni, A. R. Vijaya Lakshmi, and Bhavani N. "Prune Belly Syndrome." Case Reports in Pediatrics 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/121736.

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Prune belly syndrome is a rare congenital disorder of the urinary system, characterized by a triad of abnormalities. The aetiology is not known. Many infants are either stillborn or die within the first few weeks of life from severe lung or kidney problems, or a combination of congenital anomalies.
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Yenny, Yenny, Kusuma P. A, and Damanik M. P. "Prune-belly syndrome." Paediatrica Indonesiana 49, no. 5 (October 31, 2009): 304. http://dx.doi.org/10.14238/pi49.5.2009.304-8.

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Prune-belly syndrome, also known as Eagle-Barretsyndrome, is a congenital anomaly comprisingthree clinical findings: deficient abdominalmusculature, urinary tract anomalies, andbilateral cryptorchidism. Other clinical findings involvingrespiratory, skeletal, digestion and cardiovascular systemmay also accompany the syndrome. The incidence isapproximately 1 : 30,000 to 40,000 live births and 95%of cases occur in boys. Pulmonary hypoplasia and kidneyfailure are important prognostic factors that contributeto 60% of mortality rate. Treatment includes surgicalcorrection of the abdominal wall and urinary tract,orchidopexy and other supportive managements.l-4 Wereport 4 cases on typical Prune-belly syndrome, togetherwith other clinical variants.
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Viaño Nogueira, Pedro, Carmen Sánchez Fernández-Bravo, Marta Bascuas Arribas, and Marta Velasco Rodríguez-Belvís. "Prune belly syndrome." Medicina Clínica (English Edition) 155, no. 12 (December 2020): 568. http://dx.doi.org/10.1016/j.medcle.2019.09.012.

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16

Jennings, Russell W. "Prune Belly Syndrome." Seminars in Pediatric Surgery 9, no. 3 (August 2000): 115–20. http://dx.doi.org/10.1053/spsu.2000.7556.

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Lucas, MN, HMKN Hathlahawatta, and D. Samarage. "Prune belly syndrome." Sri Lanka Journal of Child Health 37, no. 1 (September 25, 2008): 30. http://dx.doi.org/10.4038/sljch.v37i1.90.

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18

Har-Peled, Sariel, and Benjamin Raichel. "Net and Prune." Journal of the ACM 62, no. 6 (December 10, 2015): 1–35. http://dx.doi.org/10.1145/2831230.

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19

Herman, T. E., and M. J. Siegel. "Prune belly syndrome." Journal of Perinatology 29, no. 1 (December 29, 2008): 69–71. http://dx.doi.org/10.1038/jp.2008.88.

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20

Hassett, S., G. H. H. Smith, and A. J. A. Holland. "Prune belly syndrome." Pediatric Surgery International 28, no. 3 (December 25, 2011): 219–28. http://dx.doi.org/10.1007/s00383-011-3046-6.

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21

Castro, S., and T. M. DeJong. "Developing new prune cultivars for the California dried prune industry." Acta Horticulturae, no. 1322 (September 2021): 13–18. http://dx.doi.org/10.17660/actahortic.2021.1322.3.

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García Luzardo, M. R., B. Valenciano Fuente, P. Bas Suárez, and A. M. Bello Naranjo. "Síndrome de seudo-Prune Belly: un Prune Belly sin criptorquidia." Anales de Pediatría 75, no. 1 (July 2011): 70–72. http://dx.doi.org/10.1016/j.anpedi.2010.11.023.

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23

Damani, Janhavi, Mary Jane De Souza, Nicole Strock, and Connie Rogers. "The Effect of 12-Month Prune (Dried Plum) Supplementation on Pro-inflammatory Cytokine Secretion in Postmenopausal Women." Current Developments in Nutrition 6, Supplement_1 (June 2022): 975. http://dx.doi.org/10.1093/cdn/nzac068.004.

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Abstract Objectives Osteoporosis is characterized by decreased bone strength and increased risk for fracture and is estimated to affect over 200 million women worldwide, causing approximately 9 million fractures annually. Current pharmacological therapies include antiresorptive and anabolic agents to treat low bone mineral density (BMD) but are associated with high cost, poor compliance, and adverse effects, contributing to their declining use and popularity. There is increasing interest in the potential of whole food dietary interventions to mitigate postmenopausal bone loss. Prunes (dried plums) are an abundant source of bioactive phenolic compounds that can target inflammatory pathways, which are upregulated in a hypoestrogenic environment and consequently promote bone loss. However, few studies have evaluated the effect of prunes on inflammatory mediators in postmenopausal women. This study aimed to evaluate the effect of 12 months of prune consumption (two doses, 50 and 100 g) on pro-inflammatory cytokine secretion in postmenopausal women. Methods Postmenopausal women (n = 87, 55–75 years old) were recruited for a single-center, parallel-arm, 12-month randomized controlled trial to test the effects of 50 g and 100 g prunes/day compared to a control group on inflammatory mediators. All participants received 1200 m g calcium and 800 IU vitamin D3 as standard of care. Blood was collected at baseline and after 12 months of prune consumption. Peripheral blood mononuclear cells (PBMCs) were isolated at each time point and stimulated with lipopolysaccharide (LPS). Pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, MCP-1) were quantified by ELISA in the supernatants from LPS-stimulated PBMCs and in plasma. Results Prune consumption did not alter plasma pro-inflammatory cytokine concentrations. However, in supernatants from LPS-stimulated PBMCs, there were reductions in IL-1β (P = 0.013), IL-6 (P = 0.007), and IL-8 (P = 0.049) secretion in the 100 g prunes/day group and in TNF-α (P < 0.001) secretion in the 50 g prunes/day group compared to the control group. Conclusions Consumption of 50g-100g/day of prunes for 12 months attenuated TNF-α, IL-1β, IL-6, and IL-8 production from LPS-stimulated PBMCs in postmenopausal women, suggesting a potential anti-inflammatory effect secondary to prune consumption. Funding Sources California Prune Board.
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24

Crisosto, Carlos H., Anita Nina Miller, Porter B. Lombard, and Scott Robbins. "Effect of Fall Ethephon Applications on Bloom Delay, Flowering, and Fruiting of Peach and Prune." HortScience 25, no. 4 (April 1990): 426–28. http://dx.doi.org/10.21273/hortsci.25.4.426.

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Studies in the use of fall ethephon to delay bloom in peach and prune were carried out during 1985-87. In `Italian' prune, ethephon at 250 and 500 mg·liter-l at 10% leaf-drop stage delayed bloom 13 and 16 days, respectively. Only a 5- and 7-day bloom delay occurred when applied at 50% leaf-drop stage. Fruit set and yield were not reduced in `Italian' prune when ethephon was applied at the 50% leaf-drop stage. Early applications, from vegetative maturity to the 10% leaf-drop stage, did not reduce yield in prone when trees had been previously defoliated with 3.0% urea. Early leaf removal, before vegetative maturity, caused reduction in peach flower and fruit number. In several peach cultivars, all the ethephon treatments were detrimental to flower density, fruit set, and yield, in spite of bloom delay. The ethephon-treated prune trees yielded more than the untreated trees in 1987 as a result of frost avoidance.
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Alfadhel, Majid, Marwan Nashabat, Khalid Hundallah, Amal Al Hashem, Ahmed Alrumayyan, and Brahim Tabarki. "PRUNE Syndrome Is a New Neurodevelopmental Disorder." Child Neurology Open 5 (January 1, 2018): 2329048X1775223. http://dx.doi.org/10.1177/2329048x17752237.

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PRUNE syndrome, or neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (OMIM#617481), is a new rare autosomal recessive neurodevelopmental disease that is caused by homozygous or compound heterozygous mutation in PRUNE1 on chromosome 1q21. Here, We report on 12-month-old and 30-month-old girls from 2 unrelated Saudi families with typical presentations of PRUNE syndrome. Both patients had severe developmental delay, progressive microcephaly, and dysmorphic features. Brain magnetic resonance imaging showed slight thinning in the corpus callosum, mild frontal brain atrophy, and delayed myelination in one of the patients. Both patients had the same missense mutation in PRUNE1 (c.383G>A, p.Arg128Gln), which was not reported before in a homozygous state. We compared our patients to previously reported cases. In conclusion, We suggest that clinicians consider PRUNE syndrome in any child presenting with dysmorphic features, developmental delay, progressive microcephaly, central hypotonia, peripheral spasticity, delayed myelination, brain atrophy, and a thin corpus callosum.
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SIMMONS, GILBERT F., JOSEPH L. SMILANICK, SHAMA JOHN, and DENNIS A. MARGOSAN. "Reduction of Microbial Populations on Prunes by Vapor-Phase Hydrogen Peroxide†." Journal of Food Protection 60, no. 2 (February 1, 1997): 188–91. http://dx.doi.org/10.4315/0362-028x-60.2.188.

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Vapor-phase hydrogen peroxide (VPHP) was used to disinfect prunes. Concentrated hydrogen peroxide solution (35%, wt/wt) was volatilized into a stream of dried air to approximately 3.1 mg/l (wt/vol) of hydrogen peroxide. Dried prunes obtained from commercial dehydrators were treated with VPHP and compared to untreated prunes. Microbial populations were determined for treatment comparisons. Untreated dried prune microbial populations were 155, 107, and 111 CFU/g of prunes on aerobic plate count agar, potato dextrose agar, and dichloran rose bengal agar, respectively. In contrast, VPHP-treated prune microbial populations were reduced to near zero on all media after 10 minutes of VPHP exposure. The color of prunes exposed for 20 min or longer, however, showed oxidation damage. No hydrogen peroxide residues were detected 90 days after treatment.
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27

Liu, Hansen, Kuangang Fan, Qinghua Ouyang, and Na Li. "Real-Time Small Drones Detection Based on Pruned YOLOv4." Sensors 21, no. 10 (May 12, 2021): 3374. http://dx.doi.org/10.3390/s21103374.

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To address the threat of drones intruding into high-security areas, the real-time detection of drones is urgently required to protect these areas. There are two main difficulties in real-time detection of drones. One of them is that the drones move quickly, which leads to requiring faster detectors. Another problem is that small drones are difficult to detect. In this paper, firstly, we achieve high detection accuracy by evaluating three state-of-the-art object detection methods: RetinaNet, FCOS, YOLOv3 and YOLOv4. Then, to address the first problem, we prune the convolutional channel and shortcut layer of YOLOv4 to develop thinner and shallower models. Furthermore, to improve the accuracy of small drone detection, we implement a special augmentation for small object detection by copying and pasting small drones. Experimental results verify that compared to YOLOv4, our pruned-YOLOv4 model, with 0.8 channel prune rate and 24 layers prune, achieves 90.5% mAP and its processing speed is increased by 60.4%. Additionally, after small object augmentation, the precision and recall of the pruned-YOLOv4 almost increases by 22.8% and 12.7%, respectively. Experiment results verify that our pruned-YOLOv4 is an effective and accurate approach for drone detection.
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BARÇA ŞEKER, Tuğçe, and Ayşe Çiğdem TÜTÜNCÜ. "Anesthetic Management of Prune-Belly Syndrome: Case Report." Turkiye Klinikleri Journal of Case Reports 23, no. 3 (2015): 215–19. http://dx.doi.org/10.5336/caserep.2013-35136.

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Niederholzer, Franz J. A., and R. Scott Johnson. "(329) Postharvest Urea Foliar Sprays Affect Almond and Prune Leaf Nitrogen and Sulfur Dynamics." HortScience 40, no. 4 (July 2005): 1065E—1066. http://dx.doi.org/10.21273/hortsci.40.4.1065e.

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Urea foliar sprays may be a more efficient and environmentally sound alternative to soil applied fertilizer N in the postharvest period in tree crop production in California. While tree crop sulfur (S) status can interact with tree N status to affect growth, we know of no study assessing tree crop leaf N and S dynamics following fall (postharvest) foliar urea applications. We conducted a field study to measure temporal dynamics of leaf N and leaf S (% dry weight basis) following postharvest urea sprays on prune (Prunusdomestica) and almond (Prunus dulcis). June-budded nursery stock prune (`French' on Myro 29C) and almond (`Price' on Lovell) trees were sprayed to dripping with 6.5% (w/w) and 10% (w/w) standard urea solutions, respectively. Prunes were sprayed on 1 Oct. 2003 and almonds on 18 Nov. 2003. Leaf samples were taken over a 3-week (almond) or 8-week (prune) period, beginning just before treatment. Foliar urea sprays significantly increased prune (23%) and almond (14%) leaf N compared to untreated control within 8 days of application. This affect was transient, as there were no differences in leaf N concentrations between treated and untreated trees at final leaf sampling. Urea sprays did not affect almond leaf S concentration relative to untreated trees. Prune leaf S was significantly reduced compared to untreated trees 8 days after treatment, but only on that sampling date. Remobilization of S from the leaves of control trees of either species was not apparent.
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Bower, Bruce. "Babies Prune Their Focus." Science News 169, no. 16 (April 22, 2006): 246. http://dx.doi.org/10.2307/4019218.

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Arias Vargas, Rebeca, Guadalupe Herrera Watson, and Tania Lobo Prada. "Síndrome de Prune Belly." Revista Medica Sinergia 5, no. 11 (November 1, 2020): e607. http://dx.doi.org/10.31434/rms.v5i11.607.

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El síndrome de Prune Belly o síndrome de Eagle Barret es una malformación congénita rara de etiología desconocida, caracterizada por la triada: hipoplasia de la pared muscular abdominal, criptorquidia y anomalías del tracto urinario. El cuadro clínico que desencadena es variable, dependiendo sobre todo del grado de alteración del sistema urinario y compromiso renal. La detección del síndrome de Prune Belly, en su mayoría, se realiza ya sea por medio de ultrasonografía antenatal o en el periodo neonatal. Su tratamiento suele ser conservador, con excepciones donde es necesaria la intervención quirúrgica, la cual depende de la gravedad de los síntomas, y abarca desde procedimientos modestos hasta otros más extensos.
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Teixeira, Roni Leonardo, Alexandre Petreca, and Patrícia Andréa Torres Garcia. "Síndrome de Prune Belly." Revista do Colégio Brasileiro de Cirurgiões 31, no. 6 (December 2004): 400–401. http://dx.doi.org/10.1590/s0100-69912004000600013.

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Rogers, Sarah, and Roya Sohaey. "Prune Belly With Megalourethra." Ultrasound Quarterly 29, no. 3 (September 2013): 235–36. http://dx.doi.org/10.1097/ruq.0b013e3182a0b5cf.

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Crankson, S., and S. Ahmed. "THE PRUNE BELLY SYNDROME." ANZ Journal of Surgery 62, no. 12 (December 1992): 916–21. http://dx.doi.org/10.1111/j.1445-2197.1992.tb07647.x.

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Yates, Darran. "Stop, don’t prune me!" Nature Reviews Neuroscience 19, no. 12 (November 7, 2018): 712–13. http://dx.doi.org/10.1038/s41583-018-0090-4.

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Navarro-Arenas, G. A., D. R. Orozco-Valera, E. Chiquete, and J. L. Ruiz-Sandoval. "Prune belly and schizencephaly." Neurology 83, no. 7 (August 11, 2014): 665. http://dx.doi.org/10.1212/wnl.0000000000000687.

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Davidson, Patricia. "The prune belly syndrome." Journal of Pediatric Surgery 29, no. 1 (January 1994): 117–18. http://dx.doi.org/10.1016/0022-3468(94)90563-0.

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Mukherjee, Devdeep, Joydeep Das, Prabal Niyogi, and Ritabrata Kundu. "Pseudo prune belly syndrome." Sri Lanka Journal of Child Health 46, no. 4 (December 1, 2017): 375. http://dx.doi.org/10.4038/sljch.v46i4.8388.

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Choi, Hwang. "Valves and prune belly." Current Opinion in Urology 4, no. 6 (November 1994): 309–12. http://dx.doi.org/10.1097/00042307-199411000-00004.

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Ávila-Martínez, Cristian José, Edna Gabriela Delgado-Quiñones, and Lizbeth Carlota Uriostegui-Espíritu. "Síndrome de Prune Belly." Atención Familiar 23, no. 4 (October 2016): 162–63. http://dx.doi.org/10.1016/j.af.2016.10.007.

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Ben Soussan, Patrick. "Prune Nourry, l’amazone érogène." Cancer(s) et psy(s) 6, no. 1 (February 24, 2023): 154–57. http://dx.doi.org/10.3917/crpsy.006.0154.

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Goultiaeva, Alexandra, and Fahiem Bacchus. "Exploiting QBF Duality on a Circuit Representation." Proceedings of the AAAI Conference on Artificial Intelligence 24, no. 1 (July 3, 2010): 71–76. http://dx.doi.org/10.1609/aaai.v24i1.7548.

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Search based solvers for Quantified Boolean Formulas (QBF) have adapted the SAT solver techniques of unit propagation and clause learning to prune falsifying assignments. The technique of cube learning has been developed to help them prune satisfying assignments. Cubes, however, have not been able to achieve the same degree of effectiveness as clauses. In this paper we demonstrate how a circuit representation for QBF can support the propagation of dual truth values. The dual values support the identical techniques of unit propagation and clause learning, except now it is satisfying assignments rather than falsifying assignments that are pruned. Dual value propagation thus exploits the circuit representation and the duality of QBF formulas so that the same effective SAT techniques can now be used to prune both falsifying and satisfyingly assignments. We show empirically that dual propagation yields significantperformance improvements and advances the state of the art in QBF solving.
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Burgess, Treena I., Kay Howard, Emma Steel, and Elizabeth L. Barbour. "To prune or not to prune; pruning induced decay in tropical sandalwood." Forest Ecology and Management 430 (December 2018): 204–18. http://dx.doi.org/10.1016/j.foreco.2018.08.009.

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Kobayashi, Tsuyoshi, Shin-ichiro Hino, Naohide Oue, Toshimasa Asahara, Massimo Zollo, Wataru Yasui, and Akira Kikuchi. "Glycogen Synthase Kinase 3 and h-prune Regulate Cell Migration by Modulating Focal Adhesions." Molecular and Cellular Biology 26, no. 3 (February 1, 2006): 898–911. http://dx.doi.org/10.1128/mcb.26.3.898-911.2006.

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ABSTRACT h-prune, which has been suggested to be involved in cell migration, was identified as a glycogen synthase kinase 3 (GSK-3)-binding protein. Treatment of cultured cells with GSK-3 inhibitors or small interfering RNA (siRNA) for GSK-3 and h-prune inhibited their motility. The kinase activity of GSK-3 was required for the interaction of GSK-3 with h-prune. h-prune was localized to focal adhesions, and the siRNA for GSK-3 or h-prune delayed the disassembly of paxillin. The tyrosine phosphorylation of focal adhesion kinase (FAK) and the activation of Rac were suppressed in GSK-3 or h-prune knocked-down cells. GSK-3 inhibitors suppressed the disassembly of paxillin and the activation of FAK and Rac. Furthermore, h-prune was highly expressed in colorectal and pancreatic cancers, and the positivity of the h-prune expression was correlated with tumor invasion. These results suggest that GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness.
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Mika, Augustyn, Zbigniew Buler, Jacek Rabcewicz, Paweł Białkowski, and Dorota Konopacka. "Suitability Of Plum And Prune Cultivars, Grown In A High Density Planting System, For Mechanical Harvesting With A Canopy Contact, Straddle Harvester." Journal of Horticultural Research 23, no. 2 (December 1, 2015): 69–81. http://dx.doi.org/10.2478/johr-2015-0017.

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AbstractThe relation of hand-harvesting cost in plum and prune production to the total costs amounts to 25-40%. Mechanical harvesting makes it possible to cut drastically both the harvesting and total costs. To test the suitability of plum and prune species to be mechanically harvested, an experimental grove (area 0.8 ha) was established in 2008. Three plum cultivars and one prune cultivar grafted on semi-dwarf and vigorous rootstocks were planted at high density (1250; 1666; 2500 trees·ha−1). During the span of full yielding (2012-2014), fruits were harvested mechanically with a canopy contact, straddle harvester in continuous motion, designed at the Institute of Horticulture in Skierniewice, to harvest tart cherry, and later adapted to harvesting plums and prunes. Trees grafted on semi-dwarf rootstock (‘Wangenheim Prune’) appeared to be more suitable for mechanical harvesting than strong-growing trees grafted onPrunus cerasiferaclone ‘Myrobalan’. Cumulative yield per ha (years 2012-2014) was the highest at the highest planting density. Trees grafted on the semi-dwarf rootstock had a higher productivity index than trees grafted on the vigorous rootstock. There was no significant difference in fruit quality related to planting distance. Mechanical harvesting was nearly 40 times more efficient than hand picking. The efficiency of mechanical harvest was from 85% to 90%. Over 5% of fruits were lost on the ground and from 1 to 5% of fruits were left on the tree. Up to 18% of the plums and no more than 10% of the prunes harvested mechanically showed some damage. They can be fully acceptable for processing, for up to 10 days, providing the potential deterioration processes are inhibited by cold storage. The large-fruited cultivars seem to be more susceptible to bruising than the small-fruited ones. For the latter, the share of marketable quality fruits within the mechanically harvested crop amounted to about 80%, which could be a good prognostic justifying further trials on the prune harvester.
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Mullins, Amy, Neda Akhavan, Bahram Arjmandi, and Lauren Ormsbee. "Study Protocol: Effects of Daily Prune Consumption on Lipid Profile, Inflammation, and Oxidative Stress." Current Developments in Nutrition 6, Supplement_1 (June 2022): 1150. http://dx.doi.org/10.1093/cdn/nzac072.022.

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Abstract Objectives Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Atherosclerosis is recognized as a primary underlying cause of CVD resulting from oxidative stress, chronic inflammation, and excess low-density lipoprotein cholesterol (LDL). Prunes (Prunus domestica L.) are a nutritious food with components associated with improved cardiovascular health, including soluble fiber and polyphenolic compounds. The objective of this study is to investigate the cardioprotective benefits of prunes and determine the extent to which daily prune consumption effects blood lipids, oxidative stress, and chronic inflammation in men. Methods Healthy osteopenic men aged 55 to 80 years old with body mass index of <18 to >40 data were included in this 12-month, parallel design, randomized controlled trial. Participants were placed into one of three treatment groups: 50 g/day prune, 100 g/day prune, or control (multivitamin only) for 12 months. All groups consumed a multivitamin containing 450 mg calcium and 800 IU vitamin D. During each visit (baseline, 3, 6, and 12 months) height, body weight, waist and hip circumference, heart rate, and blood pressure were assessed. Fasting blood and urine samples were collected at each time point, and participants completed a 3-day food record and validated physical activity questionnaire. Blood total cholesterol (TC), LDL-C, triglycerides, and high-density lipoprotein cholesterol (HDL-C) and biomarkers of inflammation and oxidative stress including high-sensitivity C-reactive protein (hsCRP), Tumor necrosis factor alpha (TNF-α), Interleukin 1 beta (IL-1β), lipid peroxidation (LPO), and total antioxidant capacity (TAC) will be measured. Results Study recruitment and retention is complete. Data analysis has yet to begin. Conclusions Based on the literature, whole foods high in polyphenols and soluble fiber, such as prunes, are beneficial in reducing chronic inflammation and circulating LDL-C. In the current study, we expect that long-term daily consumption of prunes will improve CVD risk factors including reductions in LDL and TC and provide antioxidant and anti-inflammatory cardiovascular benefits in older men. Findings from this research will further our understanding of the role that prunes may have in improving cardiovascular health. Funding Sources USDA, California Prune Board, and Shaklee.
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Middelhaufe, Sabine, Livia Garzia, Uta-Maria Ohndorf, Barbara Kachholz, Massimo Zollo, and Clemens Steegborn. "Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain." Biochemical Journal 407, no. 2 (September 25, 2007): 199–205. http://dx.doi.org/10.1042/bj20070408.

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The human orthologue of the Drosophila prune protein (h-Prune) is an interaction partner and regulator of the metastasis suppressor protein NM23-H1 (non-metastatic protein 23). Studies on a cellular breast-cancer model showed that inhibition of the cAMP-specific PDE (phosphodiesterase) activity of h-Prune lowered the incidence of metastasis formation, suggesting that inhibition of h-Prune could be a therapeutic approach towards metastatic tumours. H-Prune shows no sequence similarity with known mammalian PDEs, but instead appears to belong to the DHH (Asp-His-His) superfamily of phosphoesterases. In order to investigate the structure and molecular function of h-Prune, we expressed recombinant h-Prune in a bacterial system. Through sequence analysis and limited proteolysis, we identified domain boundaries and a potential coiled-coil region in a C-terminal cortexillin homology domain. We found that this C-terminal domain mediated h-Prune homodimerization, as well as its interaction with NM23-H1. The PDE catalytic domain of h-Prune was mapped to the N-terminus and shown to be active, even when present in a monomeric form. Our findings indicate that h-Prune is composed of two independent active sites and two interaction sites for the assembly of oligomeric signalling complexes.
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Ryu, Young-Hyun, Joong-Hwan Lee, Tae-Young Kwon, Seung-Han Kim, and Dong-Geun Kim. "PCR Primer Developed for Diagnosis of Xanthomonas arboricola pv. pruni in Prune." Research in Plant Disease 16, no. 2 (August 1, 2010): 125–28. http://dx.doi.org/10.5423/rpd.2010.16.2.125.

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Candresse, T., R. P. Delbos, O. Le Gall, J. Dunez, and J. C. Desvignes. "CHARACTERIZATION OF STOCKY PRUNE VIRUS, A NEW NEPOVIRUS DETECTED IN FRENCH PRUNES." Acta Horticulturae, no. 472 (November 1998): 175–82. http://dx.doi.org/10.17660/actahortic.1998.472.18.

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Donovan, Jennifer L., Anne S. Meyer, and Andrew L. Waterhouse. "Phenolic Composition and Antioxidant Activity of Prunes and Prune Juice (Prunus domestica)." Journal of Agricultural and Food Chemistry 46, no. 4 (April 1998): 1247–52. http://dx.doi.org/10.1021/jf970831x.

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