Dissertations / Theses on the topic 'Proton magnetic resonance spectroscopy'
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Gill, Simrandip Kaur. "Single voxel proton magnetic resonance spectroscopy of childhood brain tumours." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4899/.
Full textMeng, Jiqun J. "Line scan proton magnetic resonance spectroscopic imaging." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/36963.
Full textPotwarka, John J. "A proton decoupled phosphorus-31 nuclear magnetic resonance spectroscopy study of schizophrenia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0019/MQ58006.pdf.
Full textFellows, Greg A. "Proton magnetic resonance spectroscopy (1H-MRS) and transcriptional analysis of brain tumours." Thesis, St George's, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546778.
Full textD'Souza, Patricia Christina. "Quantitation of brain metabolite concentrations and temperature by proton magnetic resonance spectroscopy." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265011.
Full textRial, Franco B. "Development of proton magnetic resonance spectroscopy in human heart at 3 Tesla." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:48e60f2d-ec5c-4b20-999a-b726f8baa436.
Full textCobbold, Jeremy Francis Lars. "Imaging techniques in chronic liver disease : applications of proton magnetic resonance spectroscopy." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/11263.
Full textDavidson, Anne. "Investigation of treatment related neurotoxicity following childhood cancer by proton magnetic resonance spectroscopy." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287842.
Full textWild, James Michael. "Proton magnetic resonance spectroscopic imaging of the human brain." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/22742.
Full textLee, Kai Mon. "Solution structures of yeast ribosomal 5S and 5.8S ribonucleic acids via 500 MHz proton nuclear magnetic resonance spectroscopy /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487322984316599.
Full textTan, Peuen Clara. "Evaluation of proton magnetic resonance spectroscopy in predicting treatment response of malignant breast lesions." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440130.
Full textNaude, Natali. "Proton magnetic resonance spectroscopy to evaluate in vivo breast tissue chemistry at 3.0 Tesla." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/225943/1/Natali_Naude_Thesis.pdf.
Full textMumuni, Abdul Nashirudeen. "Investigation of brain tissue water NMR response by optimised quantitative single-voxel proton magnetic resonance spectroscopy." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4717/.
Full textKim, Jong Hwa. "Bacillus megaterium ribosomal 5S RNA structure from proton nuclear magnetic resonance spectroscopy and molecular dynamics simulations /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487683049376233.
Full textChoi, Seongjin. "Proton NMR and MRI studies of sub-millimeter sized biological objects." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1204559010.
Full textLee, Shen-Han. "¹H magnetic resonance spectroscopic imaging of tumour extracellular pH : the role of carbonic anhydrase IX." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607910.
Full textLuo, Ying. "Heme Proton Resonance Assignments and Kinetics Study in High-spin and Mixed-spin Metmyoglobin Complexes by Chemical Exchange NMR Spectroscopy." PDXScholar, 1996. https://pdxscholar.library.pdx.edu/open_access_etds/5238.
Full textPrescott, Andrew Paul. "The development and application of localised two-dimensional proton magnetic resonance spectroscopy for clinical investigation in humans." Thesis, Institute of Cancer Research (University Of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405948.
Full textMei, Chang-Sheng. "Accelerated MR Thermometry for High Intensity Focused Ultrasound Therapy." Thesis, Boston College, 2011. http://hdl.handle.net/2345/2425.
Full textThe purpose of this dissertation was to investigate the temporal limit on the ability to measure temperature changes using magnetic resonance imaging (MRI). The limit was examined in experiments using a variety of imaging techniques for MRI-based temperature measurements. We applied these methods for monitoring temperature changes in focused ultrasound (FUS) heating experiments. FUS is an attractive alternative to surgical resection due to its noninvasive character. FUS treatments have been successfully conducted in several clinical applications. MRI and MR thermometry is a natural choice for the guidance of FUS surgeries, given its ability to visualize, monitor, and evaluate the success of treatments. MR thermometry, however, can be a very challenging application, as good resolution is often needed along spatial, temporal as well as temperature axes. These three quantities are strictly related to each other, and normally it is theoretically impossible to simultaneously achieve high resolutions for all axes. In this dissertation, techniques were developed to achieve this at cost of some reduction in spatial coverage. Given that the heated foci produced during thermal therapies are typically much smaller than the anatomy being imaged, much of the imaged field-of-view is not actually being heated and may not require temperature monitoring. By sacrificing some of the in-plane spatial coverage outside the region-of-interest (ROI), significant gains can be obtained in terms of temporal resolution. In the extreme, an ROI can be chosen to be a narrow pencil-like column, and a sampling time for temperature imaging is possible with a temporal resolution of a few milliseconds. MRI-based thermal imaging, which maps temperature-induced changes in the proton resonance frequency, was implemented in two projects. In the first project, three previously described, fast MR imaging techniques were combined in a hybrid method to significantly speed up acquisition compared to the conventional thermometry. Acceleration factors up to 24-fold were obtained, and a temporal resolution as high as 320 milliseconds was achieved. The method was tested in a gel phantom and in bovine muscle samples in FUS heating experiments. The robustness of the hybrid method with respect to the cancellation of the fat signal, which causes temperature errors, and the incorporation of the method into an ultrafast, three dimensional sequence were also investigated. In the second project, a novel MR spectroscopic sequence was investigated for ultrafast one-dimension thermometry. Temperature monitoring was examined during FUS sonications in a gel phantom, SNR performance was evaluated in vivo in a rabbit brain, and feasibility was tested in a human heart. It was shown capable in a FUS heating experiment in a gel phantom of increasing temporal resolution to as high as 53 milliseconds in a three Tesla MRI. The temporal resolution achieved is an order of magnitude faster than any other rapid MR thermometry sequences reported. With this one-dimensional approach, a short sampling time as low as 3.6 milliseconds was theoretically achievable. However, given the SNR that could be achieved and the limited heating induced by FUS in the gel phantom in a few milliseconds, any temperature changes in such a short period were obscured by noise. We have analyzed the conditions whereby a temporal resolution of a few-milliseconds could be obtained
Thesis (PhD) — Boston College, 2011
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Physics
Fairbrother, Wayne J. "Phosphate interactions with proteins." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:f4aa96db-9e7c-4a18-a859-de0d90080f4f.
Full textVeale, Margaret Fiona. "Activated immune cells : 1H-NMR spectroscopy and flow cytometry studies." Thesis, The University of Sydney, 1996. https://hdl.handle.net/2123/27547.
Full textRoss, Amy Psychiatry Faculty of Medicine UNSW. "Longitudinal study of cognitive and functional brain changes in ageing and cerebrovascular disease, using proton magnetic resonance spectroscopy." Awarded by:University of New South Wales. School of Psychiatry, 2005. http://handle.unsw.edu.au/1959.4/27329.
Full textOlszewska, Agnieszka [Verfasser]. "Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy / Agnieszka Olszewska." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1182893287/34.
Full textLindskog, Magnus. "Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-160-1/.
Full textBaker, Ross E. "The time course of changes in skeletal muscle metabolites during muscle repair, as detected by proton nuclear magnetic resonance spectroscopy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0002/MQ41678.pdf.
Full textFievisohn, Elizabeth Mary. "Traumatic Brain Injury Mechanisms in the Gottingen Minipig in Response to Two Unique Input Modes." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/64280.
Full textPh. D.
Faraj, Achraf Al. "Biodistribution and biological impact of nanoparticles using multimodality imaging techniques : (Magnetic resonance imaging)." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00696221.
Full textGiapitzakis, Ioannis-Angelos [Verfasser], and Anke [Akademischer Betreuer] Henning. "Single-Voxel Proton Magnetic Resonance Spectroscopy in the Human Brain at 9.4 T : Methods and Applications / Ioannis-Angelos Giapitzakis ; Betreuer: Anke Henning." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1168634512/34.
Full textGiapitzakis, Ioannis-Angelos I. [Verfasser], and Anke [Akademischer Betreuer] Henning. "Single-Voxel Proton Magnetic Resonance Spectroscopy in the Human Brain at 9.4 T : Methods and Applications / Ioannis-Angelos Giapitzakis ; Betreuer: Anke Henning." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1168634512/34.
Full textBrief, Elana Esther. "Proton magnetic resonance spectroscopy of human brain, T¦1 and T¦2 relaxation and absolute concentrations of metabolites in patients and healthy volunteers." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/NQ56509.pdf.
Full textStory, Lisa. "Volumetric blood flow and assessment of the metabolic profile of the developing brain in growth restricted fetuses : an ultrasound and proton magnetic resonance spectroscopy study." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9098.
Full textBruylants, Gilles. "Etude par calorimétrie à titrage isotherme (ITC) et spectroscopie de résonnance magnétique nucléaire (RMN) des effets de protonation liés à l'interaction entre l'alpha-chymotrypsine et la proflavine / Gilles Bruylants." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210977.
Full textCette étude s’est essentiellement composée de trois volets. (i) La réalisation d’un modèle du complexe d’interaction afin de confronter des données structurales aux données expérimentales recueillies. (ii) L’étude de l’interaction entre l’α-chymotrypsine et la proflavine par spectroscopie de Résonance Magnétique Nucléaire (RMN) afin de mettre en évidence les résidus ionisables dont les équilibres de protonation/déprotonation sont influencés par la complexation du ligand. (iii) L’étude de la thermodynamique de l’interaction par Calorimétrie à Titrage Isotherme (ITC) et spectroscopie d’absorption en fonction de l’état d’ionisation des résidus identifiés par l’étude RMN.
Le modèle du complexe d’interaction entre l’α-chymotrypsine et la proflavine a été réalisé sur base de la structure cristallographique du complexe entre cet inhibiteur et une protéase apparentée à la chymotrypsine, la thrombine. Il ressort de l’analyse du modèle obtenu que la proflavine est profondément enfouie dans le subsite S1 de l’enzyme et présente une très grande complémentarité de surface avec cette poche hydrophobe. Nous avons également pu constater la présence de plusieurs molécules d’eau immobilisées au sein du complexe, et d’une molécule en particulier faisant office de relais de liens-H.
L’étude de l’interaction entre l’α-chymotrypsine et la proflavine par RMN du 1H a été précédée par une étude de l’effet du degré de maturité de l’enzyme sur les interactions liant les différents résidus composant la triade catalytique (Asp102, His57 et Ser195). Lors de l’activation du précurseur inactif de l’enzyme, le chymotrypsinogène, vers la forme mature, l’α-chymotrypsine, il semble en effet que le lien-H entre le NH&949;2 de l’His57 et le Oγ de la Ser195 soit affaibli, contrairement à celui qui relie le NHδ1 de cette même histidine au Oδ1 de l’Asp102. Nous rapportons pour la première fois l’observation de l’influence de la protonation de l’Asp102 sur les déplacements chimiques des protons NHδ1 et NH&949;2 de l’His57. L’étude de l’interaction entre l’α-chymotrypsine et la proflavine par RMN, nous a permis de mettre en évidence l’effet de la complexation du ligand sur l’état d’ionisation des résidus His57 et Asp102 de la triade catalytique, les pKa de ces résidus dans l’enzyme libre valant respectivement 7 et approximativement 4.
Les paramètres thermodynamiques de l’interaction α-chymotrypsine - proflavine et des différents équilibres de protonation/déprotonation qui y sont liés ont été obtenus par spectroscopie d’absorption et ITC. Cette dernière technique constitue un outil précieux pour l’étude d’interactions moléculaires car il s’agit de la seule technique expérimentale permettant la mesure directe de l’enthalpie d’interaction. Lorsque des équilibres de protonation/déprotonation sont thermodynamiquement liés à l’interaction, il s’agit également de la seule technique permettant la quantification de ces effets. En mesurant la constante d’affinité et l’enthalpie d’interaction observées à différents pH et dans différents tampons, nous avons pu, sur base du modèle obtenu par RMN, déterminer les paramètres thermodynamiques intrinsèques des différents équilibres.
La corrélation entre les données thermodynamiques obtenues par ITC et spectroscopie d’absorption et les données structurales obtenues par RMN et sur base de l’analyse du modèle du complexe d’interaction, nous a permis de rationaliser les facteurs à la base de l’interaction préférentielle de l’inhibiteur avec une des formes de l’enzyme. L’interaction entre l’α-chymotrypsine et la proflavine est la plus favorable lorsqu’à la fois l’His57 et l’Asp102 sont déprotonnés. Cette interaction est caractérisée par un terme enthalpique favorable et un terme entropique légèrement défavorable. Ce dernier terme s’expliquerait en partie par l’immobilisation dans le site d’interaction de plusieurs molécules d’eau. L’affinité entre l’α-chymotrypsine et la proflavine diminue lorsque l’His57 se protonne. La répulsion électrostatique entre les charges positives de la proflavine et de l’His57 est vraisemblablement un des facteurs permettant d’expliquer cette diminution de la constante d’affinité. Nous n’avons pu mettre en évidence d’interaction entre ces deux molécules dès lors que l’Asp102 est protonné, malgré que ce résidu soit situé relativement loin de la proflavine dans le complexe. Il s’agit donc d’un effet indirect, probablement relayé par l’His57. Tant que l’Asp102 est déprotonné, sa charge négative compenserait la charge positive de l’His57 et réduirait la répulsion électrostatique avec la proflavine, ce qui n’est plus le cas lorsque l’aspartate se protonne.
Doctorat en sciences appliquées
info:eu-repo/semantics/nonPublished
Abaei, Tafresh Alireza [Verfasser], Hans [Akademischer Betreuer] Hofsäss, Peter [Akademischer Betreuer] Dechent, Astrid [Akademischer Betreuer] Pundt, Joerg [Akademischer Betreuer] Enderlein, Stephan [Akademischer Betreuer] Waack, and Carsten [Akademischer Betreuer] Damm. "Localized Proton Magnetic Resonance Spectroscopy of Mouse Brain In Vivo at High Magnetic Field Strength / Alireza Abaei Tafresh. Gutachter: Hans Hofsäss ; Peter Dechent ; Astrid Pundt ; Joerg Enderlein ; Stefan Waack ; Carsten Damm. Betreuer: Hans Hofsäss." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/1059004631/34.
Full textZalcman, Amy. "The Use of Magnetic Resonance Imaging and Proton Spectroscopy to Identify Critical Tissues in Dogs with Duchenne Muscular Dystrophy for Future Assessment of Therapeutic Intervention| A Pilot Study." Thesis, University of Missouri - Columbia, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13850759.
Full textDuchenne’s Muscular Dystrophy is a debilitating disease that affects skeletal and cardiac muscle of 1 in 5000 male births. In the last thirty years, the gene responsible for the encoding of Dystrophin has been identified, sequenced and the variations of mutations described. There remains a void in the successful treatment of the disease although corticosteroid use has proven useful in delaying progression. Novel therapies are produced in the categories of virus-mediated gene delivery and stem cells, but evaluating their efficacy is hindered by an inability to contemporaneously assess the changes in muscle. The purpose of this pilot study was to characterize the changes in skeletal and cardiac muscle in a clinically advanced population of dogs affected with Duchenne Muscular Dystrophy. Using traditional sequences, delayed gadolinium enhancement, novel sequences and spectroscopy, changes in the investigated muscle were characterized. By establishing the differences between affected and unaffected dogs, the long-term goal of this body of work is to characterize these changes longitudinally and design a non-invasive method for tissue assessment as novel treatments are trialed.
Hatchondo, Laura. "Spectroscopie par Résonance Magnétique : Étude des variations diurnes des mesures de concentrations de métabolites cérébraux et applications cliniques." Thesis, Poitiers, 2019. http://www.theses.fr/2019POIT1804.
Full textMagnetic Resonance Spectroscopy (MRS) is a Magnetic Resonance Imaging (MRI) technique allowing a non-invasive and non-radiative study of the neurophysiology and neurobiochemistry of human body tissues. Nowadays, proton MRS (1H-MRS) is used routinely, particularly in brain tumor imaging tests, but also in neuroimaging studies exploring the cerebral metabolism of neurological or psychiatric conditions. Currently, 1H-MRS is scheduled without taking into account the time at which the examination is performed. But to date, we cannot assert if the concentrations of brain metabolites are stable over 24 hours. We know that the human body is subject to circadian rhythmicity leading to global changes including, among others, hormonal secretions (TSH, cortisol, melatonin, carbohydrate metabolism), body temperature, blood pressure.The main objective was to study, in a population of healthy subjects, diurnal variations in the concentration of brain metabolites (NAA, Cho, Cr and lactates) in 1H-MRS, in several regions of interest : caudate nucleus (CN), putamen, thalamus, anterior cingulate cortex (ACC) and posterior (PCC), insular cortex (IC), white matter (WM) of the anterior / frontal portion of the corpus callosum radiation and posterior / parietal portion of the corpus callosum radiation, at 3 "critical" times of the day : 7:30 a.m., 1:30 p.m. and 6:00 p.m. In addition, we compared the metabolic concentrations in each cerebral region according to the sex of the subjects. We looked for a modeling of these variations using the mathematical tools. Finally, we discussed the results of our clinical study on patients with severe Obsessive-Compulsive Disorder (OCD).30 healthy subjects selected in terms of age to be homogeneous were included in this descriptive, monocentric, transverse, prospective and comparative study. All of them benefited from three MRI examinations including the 1H-MRS sequence at the defined hours on an 3T MRI.Our results revealed significant variations in all the structures studied, mainly between MRI1 (7:30 a.m.) and MRI2 (1:30 p.m.), and between MRI1 and MRI3 (6:00 p.m.). Areas with the most significant changes (p <0.01) were basal ganglia, CCP and CI. Metabolites have all shown significant variations; to a lesser extent for lactates confirming that this energy buffer is stable under physiological conditions. The comparative analysis by sex of the subjects found significant differences in the CCA, CCP, NC, putamen and posterior / parietal SB of the corpus callosum. In addition, "sinusoidal" mathematical modeling appeared to be the most confident as numerical simulations, remained consistent with biological viability. It confirmed that lactates do not fluctuate during the day, but vary from one region to another suggesting functional pathway involvement and potential usefulness for clinical monitoring. Finally, we discussed again our clinical study on OCD considering the schedules chosen for MRI examinations and the potential role of lactates in the neuropathophysiological network of OCD.This work has shown that cerebral metabolism has significant variations during the day. The results of previous studies must be reconsidered if they used different schedules in and/or between the groups of subjects studied. In the future, the 1H-MRS studies will need a more rigorous protocol on the time of MRI examinations. Finally, these results suggest that cerebral metabolism may follow a circadian variability that can be modeled using mathematical tools. This opens a field of exciting opportunities for extensive investigations, with more measurement points on 24 hours and biological or even genetic correlations
Mirbahai, Ladan. "Biomarkers of cell stress and cell death detected by proton high resolution magic angle spinning (¹H HR-MAS) nuclear magnetic resonance (NMR) spectroscopy in a rat glioma cell line." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/619/.
Full textMünch, Frédéric [Verfasser]. "Metabolic profiling in experimental autoimmune myocarditis (EAM) in a rodent model using ex-vivo proton magic angle spinning magnetic resonance spectroscopy (1H-MAS-MRS) to detect myocardial injury / Frédéric Münch." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140486829/34.
Full textKoch, Katharina [Verfasser], Jaroslaw [Gutachter] Maciaczyk, and Dieter [Gutachter] Willbold. "Analysis of metabolic reprogramming during the enrichment of glioblastoma stem-like cells in glioblastoma via high resolution proton nuclear magnetic resonance (HR 1H-NMR) spectroscopy / Katharina Koch ; Gutachter: Jaroslaw Maciaczyk, Dieter Willbold." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2020. http://d-nb.info/1223705242/34.
Full textNemeth, Angéline. "Développement et validation de stratégies de quantification lipidique par imagerie et spectroscopie proton à 3T : Application à l’étude de la surnutrition." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSEI089/document.
Full textMagnetic resonance imaging and spectroscopy (MRI and MRS) are non-invasive methods that have the potential to estimate in vivo the quantity and the quality of abdominal adipose tissues (AT). The scientific and clinical context of this thesis is based on an overfeeding study entitled "Poly-Nut". One of the main objectives of this study is to analyze changes in adipose tissues in a rapid phase of weight gain. The originality and complexity of this thesis rely in the development, adaptation and comparison of several quantitative methods of MRI and MRS, for the study of lipid signal, in a clinical context, at 3T. The reliability and the validation of the measurements obtained in vivo using these techniques are the main subject of this PhD thesis. For the quantitative analysis of the spectroscopy signal, different existing methods have been compared to those developed specifically for our clinical study. According to the model function used, the nonlinear-least-squares parametric estimation applied to the lipid spectra can lead to an ill-posed nonlinear problem. We demonstrated that the use of a simplified model based on the structure of a triglyceride chain, as recently used in quantitative imaging, was a valid solution regarding the state of the art. Then different methods (MRI, MRS, Dual Energy X-ray absorptiometry, gas chromatography) were used to characterize the subcutaneous and visceral AT. We demonstrated the feasibility of MRI to follow the lipid content in the liver as well as the volume and the fatty acid composition of AT using a single multiple gradient-echo acquisition. Finally, experimental developments were carried out in parallel with the clinical study, on a 4.7T preclinical system, first, to compare different strategies for encoding the chemical shift using imaging and, secondly, to characterize MRS methods for in vivo estimation of the relative proportion of omega-3 among all fatty acids
Mantovani, Cristina de Faria. "Análise metabolômica (1H RMN) do líquido sinovial de equinos hígidos e acometidos por osteocondrite dissecante." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-10042014-144355/.
Full textOsteochondritis dissecans (OCD) is one of the most common diseases affecting young horses and one of the conditions classified as Developmental Orthopedic Diseases. As an important joint disorder, OCD is held responsible for substantial economic losses in consequence of the decrease in athletic and reproductive performance in affected horses. The condition presents a multifactorial ethiology, related to nutritional, endocrine, genetic and biomechanical factors, although its pathogeny is well established, associated with a disturbance of the process of endochondral ossification. Synovial fluid biomarkers analysis provide data regarding changes representative of inflammation and articular cartilage damage, which is why monitoring the joint cavity is an important tool for diagnosis and assessing disease progression. Proton Nuclear Magnetic Resonance spectroscopy is a holistic, simultaneous and real time approach, of the metabolites present in the synovial fluid, offering the potential to provide data regarding disease progression, response to treatment and to determine disease biomarkers. The aim of the present study was to establish the global metabolic profiling of normal and osteochondritic synovial fluid, to evaluate the applicability of the 1H RMN in the diagnosis of OCD, and to asses possible distinctions between symptomatic and asymptomatic horses. The metabolic profile determination resulted in 32 common metabolites to the three joint conditions. Moreover, 2 compounds were identified exclusively in the diseased joints, namely propylene glycol and aromatic compound, but we were unable to discern between asymptomatic and symptomatic individuals for both groups presented similarities in metabolites as well as their concentrations. When comparing spectral intensities, we observed marked increases in the metabolites glucose, glutamine, ethanol, leucine, isoleucine, dimethyl sulphone, creatine, creatinine, N-acetylglucosamine, N-acetylglutamine and -methyhistidine, besides the compounds propylene glycol and aromatic compound, in the affected joints compared to the healthy ones. Decrease in spectral intensities were related to the metabolites 3-hydroxybutirate and acetate in affected joints. Other metabolites showed no difference in intensities in all joint conditions, those being pyruvato, citrate, methionine, histidine, tyrosine, valine, lactate, alanine, glycine, glycerol and phenylalanine. PCA based statistical analysis was able to group spectra and to ascribe the importance of the aromatic compound in differentiating healthy from diseased joints. 1H RMN spectroscopy showed high reproductability between samples and sensitive in detecting synovial fluid compounds, unveiling clear diferences between the biochemical profiles of healthy and OCD affected joints, thus indicating metabolic alterations occuring with disease progression, related mainly with the cartilage degradation process. This study projects the potential of metabolomics analysis in providing a new perspective of the biochemical processes involved in OCD progression.
Ouldamer, Lobna. "Evaluation de la spectroscopie par résonance magnétique du tissu adipeux mammaire comme marqueur non invasif de la part nutritionnelle du cancer du sein." Thesis, Tours, 2016. http://www.theses.fr/2016TOUR3304.
Full textFatty acid composition of the white adipose tissue remains the most reliable qualitative biomarker of previous dietary intake of fatty acids and may provide information on the nutritional part of the risk or evolution of breast cancer. This opens the prospect of individualization of women at high nutritional risk of breast cancer that may benefit from a targeted nutritional intervention but 1) the need for biopsy and 2) subsequent time-consuming biochemical analyses hamper any application of this approach. Proton magnetic resonance spectroscopy (1H-MRS) of adipose tissue lipids represents an appealing, non-invasive approach, which could circumvent these limitations. This manuscript reports: 1) an assessment of feasibility of (1H-MRS) to evaluate the consequences of a nutritional intervention in a rat mammary tumor model on the adipose tissue fatty acid composition, 2) an assessment of the feasibility of in vivo measurement of the fatty acid composition of breast adipose tissue by (1H-MRS) on a clinical platform, 3) an assessment of the relation of specific patterns of composition of adipose tissue fatty acids with the presentation of breast cancer, and 4) a comparison with gas chromatography of (1H-MRS) data acquired on breast adipose tissue in vitro (11.7T) and in vivo (3T) on patients managed for breast cancer
Ruschke, Stefan Albert [Verfasser], Dimitrios [Akademischer Betreuer] Karampinos, Dimitrios [Gutachter] Karampinos, Axel [Gutachter] Haase, and Marion I. [Gutachter] Menzel. "Quantification of Proton Density Fat Fraction and Fatty Acid Composition of Triglycerides in Musculoskeletal Tissues using Magnetic Resonance Imaging and Spectroscopy / Stefan Albert Ruschke ; Gutachter: Dimitrios Karampinos, Axel Haase, Marion I. Menzel ; Betreuer: Dimitrios Karampinos." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/116879854X/34.
Full textZang, Tuo. "Quantitative characterization of paediatric burn blister fluid." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122968/1/Tuo_Zang_Thesis.pdf.
Full textLundberg, Staffan. "Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4133.
Full textRaffin, Luciana Sanchez. "Avaliação das lesões císticas da neurocisticercose na difusão e espectroscopia de prótons pela ressonância magnética." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-13102014-110344/.
Full textPURPOSE: The objective of this study is to describe the signal behavior of cystic neurocysticercotic lesions on diffusion-weighted imaging (DWI) and single voxel proton spectroscopy findings. MATERIALS AND METHODS: We studied 38 patients (39 lesions) with neurocysticercosis, using diffusion-weighted images and proton MR spectroscopy. The examinations were performed on a 1.5 T scanner (Signa Horizon LX: GE Medical Systems). DWI was performed in the axial plane, using a multisection single shot echo planar pulse sequence. The single voxel proton spectroscopy technique used was the point-resolved spectroscopy (PRESS) sequence with a TR of 1500 ms, short and long TE of 30/135 ms. RESULTS: The cysts presented similar signal intensity to the CSF on DWI, with comparable ADC values, ranging from 1.36 to 3.18 x 10-3 mm2/s. The detectable peaks were lactate (96.3%), succinate (48%), alanine (40%), lipids (15%), cytosolic amino acids (7.5%) and acetate (3.7%). CONCLUSION: The cysts of neurocysticercosis presented hyposignal on DWI and peaks of lactate, succinate, alanine, lipids, cytosolic amino acids and acetate in proton spectroscopy, in decreasing order of frequency
Yee, Sidney. "Solution-State Proton Nuclear Magnetic Resonance (NMR) Spectroscopic Studies of the Active Site of Myoglobins in Various Ligated States: Models for Macromolecule-Substrate Binding and Advancement of Paramagnetic NMR Techniques." PDXScholar, 1993. https://pdxscholar.library.pdx.edu/open_access_etds/1253.
Full textGudlowski, Yehonala. "Neurophysiologische Substrate von Störungen des Belohnungssystems und kognitiver Funktionen bei unmedizierten Schizophreniepatienten untersucht mittels funktioneller Magnetresonanztomographie und 1 H-Magnetresonanzspektroskopie." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 2010. http://dx.doi.org/10.18452/16047.
Full textImaging studies have demonstrated that for schizophrenic patients a correlation exists between positive symptoms and changes in the patterns of mesolimbic activity. Especially the changes in the ncl. accumbens (Nac) were interpreted in connection with the reward system. The signals indicating reward are thought to be processed by the anterior cingulum (ACC). These structures attribute meaning to the reward signals. In the anticipation phase of a potentially rewarding stimulus, dopaminergic signals from the VTA are generated in prediction of expected or aberrant outcome, thus modulating the Nac. Data indicate a direct modulation of the Nac. by glutamatergic neurons of the anterior cingulum. A major aim of this thesis is to establish a connection between the reward associated dopaminergic signals of the ncl. accumbens and the glutamatergic projections of the acc in unmedicated schizophrenic patients and healthy controls. The methods included measurements of proton magnetic resonance spectroscopy (1H-MRS) and functional MRI-scans done at a 3-Tesla tomograph. The paradigm applied was a modified version of the monetary incentive delay paradigm (Knutson et al. 2000). In healthy volunteers we found a significant negative correlation between the glutamate concentration in the ACC and the BOLD-contrast in the Nac (reward versus neutral), in contrast to the findings in schizophrenic patients. A significant higher BOLD-contrast was seen in the anticipation phase in healthy controls. The results were incorporated in a model of NMDA-R-Hypoaktivity. In addition to discussing the functional aspects for the structures involved the model was further expanded to include the hypothesis of a disturbed balance between dopamine-D1- and -D2-receptor activity and a dysfunctional hippocampal gating-process. The so constructed model suggests a profound striato-thalamo-cortical filter disturbance as the basis of the observed aberrations in the reward processing in schizophrenic disorders.
Chatel, Benjamin. "Fonction et métabolisme énergétique musculaires dans un modèle de souris drépanocytaires et identification des mécanismes responsables des échanges des protons entre le muscle et le sang." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0174.
Full textSickle cell disease (SCD) is the most frequent inherited disorder in the world. It is characterized by the synthesis of an abnormal hemoglobin S (HbS) and associated with impairments in oxygen delivery processes. If these abnormalities could impact skeletal muscle, this tissue has been rarely investigated. The aim of this thesis was to investigate muscular function and energetics in response to acute exercise, ischemia – reperfusion and endurance training in a mouse model of SCD, as well as identify the mechanisms involved in proton exchanges between muscle and blood.Sedentary and trained SCD mice were submitted to protocols of rest – stimulation – recovery and rest – ischemia – reperfusion during which muscular force and energetics (by magnetic resonance spectroscopy of phosphorus 31) were measured. Monocarboxylate transporter 1 (MCT1) haploinsufficient mice were also submitted to the stimulation protocol. Several muscles were sampled and permitted to analyze in vitro enzyme activities, content of proteins involved in pH regulation and some markers of oxidative stress.This thesis demonstrated that muscular function and energetics were impaired in SCD mice in response to both exercise and ischemia – reperfusion and that endurance training could alleviate some of these abnormalities, particularly acting on oxidative processes. We have also observed that MCT1 is involved in proton uptake by myocytes at rest, but its action is less important during exercise
Estilaei, Mohammadreza. "Proton magnetic resonance of lung." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0029/NQ27138.pdf.
Full textBorges, Ana Karina Nascimento. "Estudo do metabolismo lipídico através da espectroscopia de prótons por ressonância magnética em seres humanos obesos pré e pós-gastroplastia correlacionando com dados antropométricos, exames laboratoriais e biópsia hepática." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5151/tde-22082008-153128/.
Full textThe obesity influence on the liver and the hepatic function are themes that are not so discussed or studied, especially in Brazil. The world-wide increasing number of obese people calls the attention to this serious problem, that nowadays, became a public health problem. The number of people and the age of the people who suffer from it is increasing each day more. The non-alcoholic hepatic disease is a common pathological clinic condition caractherized by lipid deposits in hemocytes in the hepatic parenchyma. There are some injuries in the parenchyma, since a single steatosy macrogoticular to a steatohepatitis, a fibrosis and even a cirrhosis (Sass et al., 2005). The non-alcoholic steatosy hepatic (NASH) cases which lead to a cirrhosis have been known as the main causes of death with possibilities to evolute to a hepatic fail. Besides there is an increasing in the non-alcoholic hepatic disease, the means for its diagnosis still remain poorly defined. The protons spectroscopy use, in the magnetic resonance, helps on the lipidic hepatic contents numbers, although it has been used only for researches. We had as a goal the lipid metabolism study of obese human beings, related to the laboratorials data and the hepatic biopsy. On this study, where we observed obese people that were submitted to a gastric reducing surgery by the Capella techinic in the hospital Prof. Edmundo Vasconcelos in São Paulo, were included 27 pacients analyzed on the before and after operation for the datas description. It was noted a male/female general reason 9: 18 and the ages between 24 and 55 years old. The body mass indexes (IMC) were always over 40 Kg/m² to be included in a surgery. The obese patients who presented steatosy hepatic before operatory observed on the magnetic resonance and steatosy and/or steatohepatitis during the hepatic biosy went better on the pos-operatory. Finally, in obese patients the xiv steatosy hepatic degree can be analysed on its qualitativy and quantitativy through the magnetic resonance with spectroscopy, and so the cirurgical pos- treatment control, avoiding the use of invasive methods, among them the hepatic biopsy.