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Relevant bibliographies by topics / Proteome proteomics / Dissertations / Theses

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Dissertations / Theses on the topic 'Proteome proteomics'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Ciryam, Prajwal. "Proteome metastability in stress, aging, and disease." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708160.

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2

McDonald, Lucy. "Positional proteomics : advanced strategies for targeted proteome simplification." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501607.

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Proteome complexity presents a major challenge in the field of proteomics. The majority of bottom-up methods begin with proteolysis, which increases the number of analytes in the mixture by about 30-50 fold. This level of complexity demands simplification, and there is an increasing requirement for strategies and reagents that reduce the complexity of a total proteome mixture. It may be argued that when analysing a complete protein digest, for instance by standard shotgun methods, more peptides are analysed than strictly necessary. An efficient proteomic strategy simplifies the proteome while

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3

Sun, Jin. "Characterization of the egg and embryonic proteome of Pomacea canaliculata, and responses of the proteome to environmental stressors." HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1519.

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4

Woolerton, Yvonne. "Quantitative proteomics strategies to explore the Saccharomyces cerevisiae proteome." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2025519/.

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Quantitative proteomics aims at not just identifying, but accurately quantifying the cellular proteome, and while technological advances towards accurate and reliable quantification of proteins is advancing, this alone does not provide an accurate picture of a proteins role within a cell. There is a far greater level of functionality in the cellular environment than there are protein coding genes in the genome, owing partly to the organisation of individual proteins into larger assemblies. A single protein can form interactions with, potentially, a large number of other proteins, leading to a

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5

Klammer, Aaron A. "Revealing the proteome : a machine learning approach to peptide identification /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/10278.

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6

Branson, Owen E. "Improved tag-count approaches for label-free quantitation of proteome differences in bottom-up proteomic experiments." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471553685.

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7

Yee, Fong-ying Anita, and 伊芳盈. "Transcriptome and proteome of the intervertebral disc in health and disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43752354.

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8

Yee, Fong-ying Anita. "Transcriptome and proteome of the intervertebral disc in health and disease." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43752354.

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9

Fisher, Christal. "Quantitative analysis of the plasma proteome in pre-eclampsia." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/quantitative-analysis-of-the-plasma-proteome-in-preeclampsia(3e207341-ebb9-4cb0-b7ea-34b9b110eda6).html.

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There is currently no clinically useful screening test available to identify nulliparous women at high risk of developing pre-eclampsia. This study aimed to identify novel biomarkers using hypothesis generating proteomic methods applied to plasma samples obtained prior to clinical diagnosis of pre-eclampsia. Plasma samples taken at 15 weeks gestation from women who subsequently developed late pre-eclampsia (> 34 weeks), early pre-eclampsia (< 34 weeks) and two distinct groups of women with uncomplicated pregnancies (each n=12) were pooled. Pooled plasma was immunodepleted, labelled using iTRAQ

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10

Tabb, David L. "Bioinformatics of proteomic tandem mass spectra : selection, characterization, and identification /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/10847.

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11

Ozgazi, Nese. "Proteome Analysis Of Blumeria Graminis F. Sp. Hordei Inoculated Barley." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611152/index.pdf.

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Blumeria graminis f. sp. hordei is a biotroph pathogen that causes powdery mildew disease in barley. In this study, Pallas01 and Pallas03 barley lines having Mla1, Ml (Al2) and Mla6, Mla14 R-genes were inoculated with Bgh103(64/01) race of the Blumeria graminis f. sp. hordei having avirulence and virulence to Pallas01 and Pallas03, respectively. The proteins were isolated from the three biological replicates of 12, 24, and 48 hpi samples following the method in Rampitsch et al., 2006. These there biological replicates of three time points together with the mock inoculated plant proteins were s

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12

Street, Jonathan Mark. "Exosomal proteome as a source of biomarkers for human disease." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5895.

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Exosomes are small lipid membrane bound vesicles formed as part of the endosomal pathway and released into the extracellular space following fusion of late endosomes with the plasma membrane. Exosomes have been shown to have a variety of biological roles and may represent a novel source of disease biomarkers. The objectives of this project were to develop a panel of techniques for identifying exosomes in human urine then establish an in vitro model to determine whether exosomes change with cellular activation. We then used the techniques developed with human urine to determine whether human ce

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13

Mackenzie, Rebecca. "Investigating the heat shock response of the yeast proteome via quantitative proteomics." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-heat-shock-response-of-the-yeast-proteome-via-quantitative-proteomics(ea5b80a1-6a4a-4207-847e-aefd3e6e4832).html.

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Proteostasis, the regulation of protein abundance and function in cellular systems, underpins the ability of organisms to deal with environmental challenge such as heat shock stress. In this thesis, a quantitative study of this process at the molecular level has been undertaken using the model eukaryote S. cerevisiae to characterise the protein level response to heat shock. Although well studied, much of the previous work has focussed on changes at the mRNA levels or relative changes in protein expression. To address this, an absolute quantification strategy was developed utilising the QconCAT

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14

Star, Alexandra. "Enrichment and Identification of Methylation at the Proteome Level." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34178.

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Methylation is a post-translational modification which occurs on lysine and arginine residues. Methylation is difficult to detect due to its low abundance and lack of charge. Our laboratory previously developed a novel enrichment approach, ProMENADe, for lysine and arginine methylation in the human embryonic kidney (HEK) 293T cell line which is coupled with mass spectrometry. Simplifying a lysate with subcellular fractionation prior to enrichment increased the identification of methylation sites by 39.5% while using multiple proteases for digestion increased identification by 27%. Combining

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15

Sainz-Fuertes, Ricardo. "Applied proteomics : using the peripheral proteome to identify a surrogate marker of schizophrenia." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/applied-proteomics(0e1764b2-7d60-4140-9213-0ac8bc2afd13).html.

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Classical proteomic techniques have been used in medicine for biomarker discovery and have recently entered the arena of neurodegenerative disorders. Biomarkers for disorders such as Huntington’s, Parkinson’s and Alzheimer’s diseases are currently being developed and tested for use in early detection, disease progression, prognosis and response to treatment. However, psychiatric disorders have been less researched to date. In this thesis, a classic proteomic approach was used (1) to examine alterations in molecular pathways determined by a well known high-risk schizophrenia (SCZ) gene (DISCI);

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16

Koutroukides, Theodoros Alexis. "Serum proteome profiling using amine-reactive isobaric tagging mass spectrometry in schizophrenia." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607699.

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17

Sherman, James. "Proteome-scale kinetic processes : methods and applications /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10284.

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18

Scuderi, Richard Anthony. "The Effects of Diet on the Bovine Milk Proteome." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/846.

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Protein is an important fraction within bovine milk. This milk protein is not only vital for calf growth and development, but also includes bioactive proteins and peptides that have been shown to enhance the health of animals and humans. Research efforts are focusing on factors, such as nutrition, that can influence the quantity and profile of proteins within the bovine milk proteome. The research outlined herein investigated the impact of diet on the bovine milk proteome. The first experiment examined whether dietary inclusion of grape marc (GM), a condensed tannin (CT) containing by-product

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19

Huang, Peiwu. "Method development and application for spatial proteome and glycoproteome profiling." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/788.

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Tissues are heterogeneous ecosystems comprised of various cell types. For example, in tumor tissues, malignant cancer cells are surround by various non-malignant stromal cells. Proteins, especially N-linked glycoproteins, are key players in tumor microenvironment and respond to many extracellular stimuli for involving and regulating intercellular signaling. Understanding the human proteome and glycoproteome in heterogeneous tissues with spatial resolution are meaningful for exploring intercellular signaling networks and discovering protein biomarkers for various diseases, such as cancer. In th

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20

So, King-yan Leo, and 蘇敬仁. "Dynamics of the mammalian nuclear proteome during influenza viral infection using SILAC-based MS quantitative proteomics." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47869860.

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Influenza has resided with the human race long before we have any written record of it. Its death toll is one of the highest among all other virus. In recent history, pandemic outbreaks of influenza have caused even more deaths. Therefore it is of great importance that we focus our resources on understanding its viral components and functions. In this study, chimeric mutagenesis was used to investigate the antigenic variance of antibodies I50C and I131B on H1N1 and H5N1 NP. It was revealed from previous study that antibodies I50C and I131B can detect H1N1 NP but not H5N1 NP. NP from influen

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21

Grady, Joshua Terrence Wilson. "Adapting Quantitative Protein and Phosphorylation Analyses to a Proteome-Wide Scale." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10852.

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Liquid chromatography coupled tandem mass spectrometry (LC-MS/MS) has become the preferred method for large-scale peptide and phosphopeptide identification and quantification. The dominance of LC-MS/MS is the result of improved chromatographic, mass spectrometry and bioinformatic technologies. The applications of these technological improvements drive biological innovation by expanding the realm of possible experimentation, facilitating the creation and evaluation of novel hypotheses. Such improvements are the focus of this dissertation. New technologies are presented and their proteome wide a

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22

Mujahid, Hana, Feng Tan, Jian Zhang, Babi Ramesh Nallamilli, Ken Pendarvis, and Zhaohua Peng. "Nuclear proteome response to cell wall removal in rice (Oryza sativa)." BioMed Central, 2013. http://hdl.handle.net/10150/610238.

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Plant cells are routinely exposed to various pathogens and environmental stresses that cause cell wall perturbations. Little is known of the mechanisms that plant cells use to sense these disturbances and transduce corresponding signals to regulate cellular responses to maintain cell wall integrity. Previous studies in rice have shown that removal of the cell wall leads to substantial chromatin reorganization and histone modification changes concomitant with cell wall re-synthesis. But the genes and proteins that regulate these cellular responses are still largely unknown. Here we present an e

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23

Honan, Mallory Cate. "Examination Of Bovine Rumen Fluid And Milk Fat Globule Membrane Proteome Dynamics." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1164.

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Proteomic technology has been increasingly incorporated into agricultural research, as characterization of proteomes can provide valuable information for potential biomarkers of health and physiological status of an animal. As dairy cattle are a dominant production animal in the USA, their biofluids such as milk, blood, urine, and rumen fluid have been examined by proteomic analysis. The research outlined herein was performed to further characterize the dynamics of specific proteomes and relate them to dairy cattle physiology. The first experiment evaluated the diurnal dynamicity of the rumen

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24

Schlüsener, Daniela. "Proteomics of membrane proteins: development and application for the membrane proteome of Corynebacterium glutamicum." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=978723678.

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25

Berglund, Lisa. "Selection of antigens for antibody-based proteomics." Doctoral thesis, Stockholm : School of Biotechnology, Royal Institute of Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4706.

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26

Sun, Benjamin Boyang. "Genetic determinants of the human plasma proteome and their application in biology and disease." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269287.

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Proteins are the primary functional units of biology and the direct targets of most drugs, yet there is limited knowledge of the genetic factors determining inter-individual variation in protein levels (protein quantitative trait loci (pQTLs)). Limitations in high-throughput proteomic measurement technology have meant well-powered genome-wide association studies for large number of proteins so far have lagged behind many of the other "omic" studies such as transcriptomics and metabolomics. This is made more challenging by the complexity of human plasma, characterised by high dynamic range span

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27

Leary, Dagmar Hajkova. "CIRCADIAN PROTEOME CHANGES IN PHOTORECEPTOR OUTER SEGMENTS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1264276011.

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28

Lai, Kwok-wai, and 賴國偉. "Proteome analysis of anther-development-related proteins in a thermo-sensitive male sterile rice mutant." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29517862.

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29

Tuli, Leepika. "Proteome Profiling of Saccharomyces cerevisae stress response to Cumene Hydroperoxide (CHP)." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28620.

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Oxidative stress, described as the state of disturbed intracellular redox balance, has been associated with several human conditions including ageing, apoptosis, cancer, autoimmune and neuro-degenerative diseases. Stress studies have shown that reactive oxygen species (ROS) and reactive nitrogen species (RNS) along with its intermediates can attack essential cell targets such as: DNA, proteins, lipids and carbohydrates, leaving behind dysfunctional biologic molecules. In effect, a cellâ s primary response is to involve several defense mechanisms that are under a complex and intricate regulato

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30

Sarvaiya, Hetal Abhijeet. "Mass Spectrometric Characterization of the MCF7 Cancer Cell Line: Proteome Profile and Cancer Biomarkers." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/42169.

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The discovery of cancer biomarkers is crucial in the clinical setting to facilitate early diagnosis and treatment, thereby increasing survival rates. Proteomic technologies with mass spectrometry detection (MS) have the potential to affect the entire spectrum of cancer research by identifying these biomarkers. Simultaneously, microfabricated devices have evolved into ideal analysis platforms for minute amounts of sample, with promising applications for proteomic investigations and future biomarker screening. This thesis reports on the analysis of the proteomic constituents of the MCF7 breast c

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31

Modak, Swananda Rajan. "Effects of Aβ42 on the human proteome and compound library screening using cellular models of Alzheimer's disease". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/effects-of-a42-on-the-human-proteome-and-compound-library-screening-using-cellular-models-of-alzheimers-disease(4cca38b1-fd3f-4ef1-bde1-e16cf227ef68).html.

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The neuropathological process in Alzheimer's disease (AD) is characterized by both intra and extracellular Aβ42 aggregates. The neuropathological process of AD is complex and the exact cause of Aβ aggregation leading towards neuronal death is yet unknown. Several events are implicated towards the development of AD including changes within the proteome. With more than 30 million people currently affected with AD, there is still no cure for AD. In this project we seek to identify differential protein profiles by undertaking a comparative analysis of the intracellular and extracellular effects of

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32

Macarthur, Deborah Jane. "Mapping the proteome of Streptococcus gordonii." University of Sydney. Health Science, 2005. http://hdl.handle.net/2123/686.

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Streptococcus gordonii is a primary coloniser of the tooth surface where it efficiently ferments carbohydrates at pH levels above 6.0. By not being able to maintain the pH of dental plaque to a level required for enamel dissolution, the dominance of S. gordonii in dental plaque is considered a sign of a healthy oral cavity. However, upon entering the bloodstream and encountering a rise in pH, S. gordonii may become pathogenic, being one of the major causative organisms associated with infective endocarditis. Proteome analyses of S. gordonii grown at steady state in a chemostat allowed t

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33

Macarthur, Deborah Jane. "Mapping The Proteome Of Streptococcus Gordonii." Thesis, The University of Sydney, 2005. http://hdl.handle.net/2123/5097.

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Streptococcus gordonii is a primary coloniser of the tooth surface where it efficiently ferments carbohydrates at pH levels above 6.0. By not being able to maintain the pH of dental plaque to a level required for enamel dissolution, the dominance of S. gordonii in dental plaque is considered a sign of a healthy oral cavity. However, upon entering the bloodstream and encountering a rise in pH, S. gordonii may become pathogenic, being one of the major causative organisms associated with infective endocarditis. Proteome analyses of S. gordonii grown at steady state in a chemostat allowed t

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34

Chitteti, Brahmananda Reddy. "Proteome and phosphoproteome dynamic change during cell dedifferentiation in Arabidopsis thaliana." Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-07172007-035002.

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35

Wood, Laura Charlotte. "Understanding kinetochore dependency pathways using vertebrate conditional knockout cell lines and quantitative proteomics." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8964.

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When cells divide, a series of events must proceed in a timely and co-ordinated manner to ensure that all DNA is replicated and partitioned equally between the two daughter cells. A central component of this process is the kinetochore, a large proteinaceous complex (>100 proteins) found within the centromere of all chromosomes. During the dynamic process of cell division, this machinery must be able to capture microtubules, promote chromosome movements towards the spindle midzone and ensure that segregration only occurs once this alignment has been successfully completed. This requires intrica

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36

Schneider, Sonja [Verfasser], and Stefan [Akademischer Betreuer] Stevanovich. "Plasma Proteome Analysis Using Peptide Group-Specific Immunoprecipitation "Triple X Proteomics" / Sonja Schneider ; Betreuer: Stefan Stevanovich." Tübingen : Universitätsbibliothek Tübingen, 2012. http://d-nb.info/1162842873/34.

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37

Agana, Bernice A. "Mass Spectrometry-Based Proteomics and Metabolomics: Understanding Protein Interactions, Proteome Complexity and Perturbations in Cellular Metabolism." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574636665012436.

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38

Fava, Marika. "Proteomics analysis of intracellular and extracellular proteome in aneurysmal patients with bicuspid and tricuspid aortic valve." Thesis, St George's, University of London, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706521.

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Background. Thoracic aortic aneurysm (TAA) is a degenerative disease of the aortic wall and is associated with an increased risk of aortic rupture. TAA is a more prevalent complication in patients with bicuspid aortic valve (BAV) compared to those with tricuspid aortic valve (TAV). Objectives. We aimed to investigate first, changes in intracellular proteins by comparing BAV and TAV patients with aneurysm, and second, regional changes in extracellular matrix (ECM) proteins by comparing the lesser (concavity) and the greater (convexity) aortic curvatures of BAV patients with and without aneurysm

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39

Aras, Taskin Asli. "Proteome-wide Analysis Of Functional Roles Of Bacilysin Biosynthesis In Bacillus Subtilis." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612409/index.pdf.

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The members of the genus Bacillus produce a wide variety of secondary metabolites with antimetabolic and pharmacological activities. Most of these metabolites are small peptides that have unusual components and chemical bonds and synthesized nonribosomally by multifunctional enzyme complexes called peptide synthetases. Bacilysin, being produced and excreted by certain strains of Bacillus subtilis, is one of the simplest peptide antibiotics known. It is a dipeptide with an N-terminal L-alanine and an unusual amino acid, L-anticapsin, at its C-terminal. Recently, ywfBCDEF operon of B. subtilis 1

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40

Pizol, José Vitor. "The effects of rockrose extract feed inclusion on the wool proteome of portuguese White Merinos." Master's thesis, ISA, 2020. http://hdl.handle.net/10400.5/21503.

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Mestrado em Engenharia Zootécnica - Produção Animal / Instituto Superior de Agronomia / Faculdade de Medicina Veterinária. Universidade de Lisboa<br>This study was carried out with the objective of evaluating the effect of feeding extract of rockrose (Cistus ladanifer L.), a perennial shrub commonly found in the marginal regions of Portugal and rich in condensed tannins (CT), and its effect on the wool proteome of Portuguese White Merinos. Twenty-four Portuguese White Merinos lambs were fed a diet restricted in protein and composed of grass hay (15%) and concentrate (85%), where they were dist

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41

So, Wing-yan. "Proteome and gene expression analysis in white adipose tissue of diet-induced obese mice." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39367435.

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42

Öztürk, Özgür. "Feature extraction and similarity-based analysis for proteome and genome databases." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1190138805.

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43

Romas, Laura. "Understanding the mucosal fluid proteome in rectal susceptibility to HIV infection." PLoS One, 2014. http://hdl.handle.net/1993/30854.

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Objective: The rectal mucosa is highly susceptible to HIV infection. Mucosal fluid contains soluble immune proteins that influence HIV infection, and previous studies have shown unique mucosal protein expression in HIV-exposed seronegative (HESN) populations, which may contribute to reduced HIV susceptibility. However, the key correlates of susceptibility at the rectal mucosa have not been well defined, which is a critical knowledge gap for our understanding of HIV pathogenesis. Methods: Rectal lavage from low risk men was screened for HIV-neutralizing activity in a TZM-bl reporter cell line a

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44

Arruda, Paulo Cesar Lopes de. "Effects of different lipid sources on housing characteristics, lipid profile and proteome Longissimus Dorsi lambs woolless." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16272.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>The study was conducted to evaluate the influence of supplementation of different lipid sources on performance and quantitative characteristics of housing and not housing, fatty acid profile and muscle proteome Longissimus dorsi of Santa Ines lambs fed different additional sources of lipids. 35 lambs bulls were used, with initial body weight (13 Â 1.80 kg) and approximately two months in a randomized block design with five treatments and seven repetitions. The treatments consisted of five diets, one free additional lipid

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Massey, Christopher L. "THE EFFECTS OF QUORUM SENSING AND TEMPERATURE ON THE SOLUBLE PROTEOME OF VIBRIO SALMONICIDA." DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1603.

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Vibrio salmonicida causes cold-water vibriosis in salmon populations around the world and causes financial damage to fisheries designed to farm these salmon. Very little is known about the physiology of how V. salmonicida causes disease and measures to contain vibriosis are restricted to either vaccinating individual fish against disease or administering antibiotics when an outbreak is detected. These procedures are costly and increase the risk for selection of antibiotic-resistant V. salmonicida strains. A recent reoccurrence of outbreaks in Norwegian fisheries provided incentive to better un

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46

Kimzey, Michael John. "Identification, Characterization, and Quantification of Dicarbonyl Adducts in the Plasma Proteome in Type-2 Diabetes." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145123.

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Glyco-oxidation is linked to the pathophysiology of diabetes and diabetic complications. The process of glyco-oxidation generates reactive dicarbonyls, which form adducts on arginine residues in distributions throughout the proteome that are site-specific depending on the protein microenvironment. Dicarbonyl adducts are thus markers for glyco-oxidative stress. Various approaches using mass spectrometry permits the identification, localization, and quantification of these dicarbonyl adducts. Using MG as a model dicarbonyl, a shotgun proteomics approach identified the sites for modification of m

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47

Sun, Jinchun. "A MASS SPECTROMETRY-BASED STUDY OF SERUM BUTYRYLCHOLINESTERASE INHIBITION FROM PESTICIDE EXPOSURE AND ORGANOPHOSPHATE PESTICIDE-INDUCED PROTEOME ALTERATION." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/290.

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Pesticides including organophosphates (OPs) and carbamates (CBs) are widelyused to control undesirable pests. These compounds are neurotoxic and inhibithydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase. Public healthconcerns have increased with the escalating usage of pesticides. Reliable monitoringprograms are required to detect and quantify pesticide exposure, as well as to promotean understanding of their neurotoxic properties. In this dissertation, both theanticholinergic (Part I) toxicity and neurotoxicity in neuroblastoma cells (Part II) ofpesticides were explored

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48

Arivalagan, immanuel Jaison Rathina Raj. "Insights from shell proteome : biomineralization control and environmental adaptation in bivalves." Thesis, Paris, Muséum national d'histoire naturelle, 2017. http://www.theses.fr/2017MNHN0026/document.

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Le processus de biominéralisation confère aux organismes qui le développent une valeur adaptative. La coquille carbonatée des mollusques intègre les fonctions de protection biomécanique à différentes échelles. La coquille résulte de l'association de composés inorganiques et d'une matrice organique protéique, médiatrice du contrôle biologique de la minéralisation. L'analyse du protéome de la coquille chez 4 espèces de bivalves met en évidence deux patrons fonctionnels et leur degré de conservation phylogénétique : l'un lié au contrôle de la minéralisation stricto sensu ; l'autre à la protection

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49

Strandberg, Linnéa. "Isolation of the native chloroplast proteome from plant for identification of protein-metabolite interactions." Thesis, KTH, Proteinvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-301783.

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För att kunna livnära en växande population behöver avkastningen på skördar öka. En lösning på dettaär att optimera plantornas fotosyntes, vilket innefattar förbättrad koldioxidfixering. För att lyckas meddet krävs kunskap i hur reglering av nyckelproteiner i kloroplasten går till. Syftet med detta projekt är identifiera möjliga reglerande protein-metabolitinteraktioner i Arabidopsis thaliana. Målproteinerna ärde 11 enzymerna i Calvin-Benson-Basshamcykeln. Metaboliterna som testas är 3PGA, ATP, FBP, GAP, vilka är mellan produkter eller kofaktorer i cykeln; 2PG, som är en produkt av en konkurre

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50

So, Wing-yan, and 蘇詠欣. "Proteome and gene expression analysis in white adipose tissue of diet-induced obese mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39367435.

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