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1

Sharma, Virender K. Oxidation of Amino Acids, Peptides, and Proteins. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118482469.

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2

Fredriksson, Åsa. On the role of protein oxidation and heat shock proteins in senescence and fitness. Göteborg: Göteborg University, 2006.

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3

Davies, M. J. Radical-mediated protein oxidation: From chemistry to medicine. Oxford: Oxford University Press, 1997.

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4

1964-, Dalle-Donne Isabella, Scaloni Andrea, and Butterfield D. Allan, eds. Redox proteomics: From protein modifications to cellular dysfunction and diseases. Hoboken, N.J: Wiley-Interscience, 2006.

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5

J, Lunec, ed. Measuring in vivo oxidative damage: A practical approach. Chichester: Wiley, 2000.

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6

Grune, Tilman, Betul Catalgol, and Tobias Jung. Protein Oxidation and Aging. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118493038.

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7

Feige, Matthias J., ed. Oxidative Folding of Proteins. Cambridge: Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788013253.

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8

1938-, Flohé L., and Harris James R, eds. Peroxiredoxin systems: Structures and functions. New York: Springer, 2007.

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9

Catala, Angel. Reactive oxygen species, lipid peroxidation, and protein oxidation. New York: Nova Publishers, 2014.

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10

Moroder, Luis, and Johannes Buchner, eds. Oxidative Folding of Peptides and Proteins. Cambridge: Royal Society of Chemistry, 2008. http://dx.doi.org/10.1039/9781847559265.

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11

Oxidative folding of peptides and proteins. Cambridge, UK: Royal Society of Chemistry, 2009.

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12

Lantto, R. Protein cross-linking with oxidative enzymes and transglutaminase: Effects in meat protein systems. [Espoo, Finland]: VTT Technical Research Centre of Finland, 2007.

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13

Lai, Laura R. B. Protein oxidation occurs in cardiomyocytes exposed to an in vitro model of hypoxia/reperfusion injury. Ottawa: National Library of Canada, 1996.

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14

Offen, Daniel. The molecular basis for neurodegenerative diseases. Trivandrum, Kerala, India: Research Signpost, 2007.

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15

Morozov, Vladimir I. Exercise and cellular mechanisms of muscle injury. Hauppauge, N.Y: Nova Science, 2009.

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16

Sŏnggyun'gwan Taehakkyo (Seoul, Korea). Sanhak Hyŏmnyŏktan. TGF-beta e ŭihan oncogenic Epithelial-Mesenchymal Transition (EMT) yubal inja rosŏ hangsanhwa tanbaekchildŭl ŭi yŏkhal kyumyŏng kwa kijŏn yŏn'gu =: Molecular characterization of distinct roles of anti-oxidative proteins and their signaling mechanism in the oncogenic epithelial-mesenchymal transition by TGF-beta. [Seoul]: Pogŏn Pokchi Kajokpu, 2009.

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17

Jens, Pietzsch, and Research Signpost (Trivandrum India), eds. Protein oxidation and disease. Trivandrum, Kerala, India: Research Signpost, 2006.

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18

Rokita, Steven E., and Virender K. Sharma. Oxidation of Amino Acids, Peptides, and Proteins. Wiley & Sons, Incorporated, John, 2012.

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19

Rokita, Steven E., and Virender K. Sharma. Oxidation of Amino Acids, Peptides, and Proteins: Kinetics and Mechanism. Wiley & Sons, Limited, John, 2012.

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20

Oxidation Of Amino Acids Peptides And Proteins Kinetics And Mechanism. John Wiley & Sons, 2012.

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21

Rokita, Steven E., and Virender K. Sharma. Oxidation of Amino Acids, Peptides, and Proteins: Kinetics and Mechanism. Wiley & Sons, Incorporated, John, 2012.

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22

Rokita, Steven E., and Virender K. Sharma. Oxidation of Amino Acids, Peptides, and Proteins: Kinetics and Mechanism. Wiley & Sons, Incorporated, John, 2012.

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23

Rokita, Steven E., and Virender K. Sharma. Oxidation of Amino Acids, Peptides, and Proteins: Kinetics and Mechanism. Wiley & Sons, Incorporated, John, 2012.

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24

Protein Oxidation and Aging Wiley Series in Protein and Peptide Science. John Wiley & Sons, 2012.

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25

Harris, J. Robin, and Leopold Flohé. Peroxiredoxin Systems: Structures and Functions. Springer, 2010.

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26

Handbook of Flavoproteins Vol. 1: Oxidases, Dehydrogenases and Related Systems. De Gruyter, Inc., 2012.

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27

H. A. O. Hill (Editor), P. J. Sadler (Editor), and A. J. Thomson (Editor), eds. Metal Sites in Proteins and Models: Redox Centres (Springer Desktop Editions in Chemistry). Springer, 1999.

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28

Desiderio, Dominic M., Nico M. Nibbering, D. Allan Butterfield, Isabella Dalle-Donne, and Andrea Scaloni. Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases. Wiley & Sons, Incorporated, John, 2006.

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29

Desiderio, Dominic M., Nico M. Nibbering, D. Allan Butterfield, Isabella Dalle-Donne, and Andrea Scaloni. Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases. Wiley & Sons, Incorporated, John, 2008.

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30

Bombarda, Elisa, Gary Cecchini, Verónica I. Dumit, Csaba Bajzath, and David Ballou. Complex Flavoproteins, Dehydrogenases and Physical Methods Vol. 2. de Gruyter GmbH, Walter, 2013.

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31

Ceccarelli, Eduardo, Antonio J. Costa Filho, Pimchai Chaiyen, Donald Becker, and Claudia Binda. Oxidases, Dehydrogenases and Related Systems Vol. 1. de Gruyter GmbH, Walter, 2012.

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32

Miller, Susan, Bruce Palfey, and Russ Hille. Set : Handbook of Flavoproteins : Volume 1 : Oxidases, Dehydrogenases and Related Systems. Volume 2: Complex Flavoproteins, Dehydrogenases and Physical Methods. de Gruyter GmbH, Walter, 2013.

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33

Decker, Eric Andrew. Catalysis of linoleate oxidation by heme and non-heme soluble chicken muscle proteins. 1985.

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34

Packer, Lester, and Karel W. A. Wirtz. Signalling Mechanisms -- from Transcription Factors to Oxidative Stress. Springer London, Limited, 2013.

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35

Packer, Lester, and Karel W. A. Wirtz. Signalling Mechanisms - From Transcription Factors to Oxidative Stress. Springer London, Limited, 2012.

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36

H. A. O. Hill (Editor), P. J. Sadler (Editor), and A. J. Thomson (Editor), eds. Metal Sites in Proteins and Models: Redox Centres (Structure and Bonding). Springer-Verlag Telos, 1998.

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37

Desiderio, Dominic M., and Nico M. Nibbering. Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases (Wiley - Interscience Series on Mass Spectrometry). Wiley-Interscience, 2006.

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38

S, Bendall D., ed. Protein electron transfer. Oxford, UK: Bios Scientific Publishers, 1996.

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39

Protein Electron Transfer. Taylor & Francis Group, 2020.

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40

(Editor), J. Lunec, and H. R. Griffiths (Editor), eds. Measuring In Vivo Oxidative Damage: A Practical Approach. Wiley, 2000.

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41

O, Hill H. A., Sadler P. J, Thomson A. J, and Chapman S. K, eds. Metal sites in proteins and models. Berlin: Springer, 1997.

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42

O, Hill H. A., Sadler P. J, and Thompson A. J, eds. Metal sites in proteins and models: Iron centres. Berlin: Springer, 1997.

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43

O, Hill H. A., Sadler P. J, and Thompson A. J, eds. Metal sites in proteins and models: Redox centres. Berlin: Springer, 1998.

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44

Allen, Geoffrey. Proteins: Proteins in Oxidative Metabolism (Proteins). JAI Press, 1995.

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45

Grune, Tilman, Vladimir Uversky, Betul Catalgol, and Tobias Jung. Protein Oxidation and Aging. Wiley & Sons, Incorporated, John, 2012.

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46

Grune, Tilman, Vladimir Uversky, Betul Catalgol, and Tobias Jung. Protein Oxidation and Aging. Wiley & Sons, Incorporated, John, 2012.

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47

Grune, Tilman, Vladimir Uversky, Betul Catalgol, and Tobias Jung. Protein Oxidation and Aging. Wiley & Sons, Incorporated, John, 2012.

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48

Grune, Tilman, Vladimir Uversky, Betul Catalgol, and Tobias Jung. Protein Oxidation and Aging. Wiley & Sons, Incorporated, John, 2012.

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49

Grune, Tilman, Vladimir Uversky, Betul Catalgol, and Tobias Jung. Protein Oxidation and Aging. Wiley & Sons, Limited, John, 2012.

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50

Gray, Doug, Carole Proctor, and Tom Kirkwood. Biological aspects of human ageing. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0001.

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At the molecular and cellular levels human ageing is characterized by the accumulation of unrepaired random damage, and an accompanying loss of function. A major source of damage is oxidative stress caused by the generation of reactive oxygen species as a by-product of respiration. DNA and proteins are both susceptible to damage but whereas DNA damage repair systems exist, faulty proteins are generally removed by protein degradation systems. During ageing these systems become less efficient and the subsequent accumulation of damaged protein promotes protein aggregation, a process which is especially problematic in the ageing brain. Other aspects of ageing include genetic and epigenetic changes, mitochondrial dysfunction, telomere shortening, and cellular senescence, all subject to stochasticity. The complexity of the biology of ageing has led to an increase in the use of systems biology approaches whereby the use of mathematical modelling and bioinformatic tools complement the more traditional experimental approaches.
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