Dissertations / Theses on the topic 'Proteins – Identification'
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Arbuckle, Janeen Lynnae. "Identification and characterization of domains in non-core RAG1." Oklahoma City : [s.n.], 2007.
Find full textWinter, Sherry Lynn. "Identification of BRCA1 interacting proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0026/MQ50432.pdf.
Full textBaakdah, Fadi. "Identification of PfCRT interacting proteins." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121534.
Full textLa forme létale du paludisme humain est causée par le plus important parasite protozoaire humain, Plasmodium falciparum, responsable d'environ ~1 million de mort annuellement. Le traitement et la prévention du paludisme dépend des médicaments antipaludiques. Le substitut synthétique de la quinine, la chloroquine, était le traitement le plus efficace pour cette maladie. La montée du paludisme résistant à la chloroquine dans les pays endémiques a supprimé les efforts de contrôle. La résistance à la chloroquine a été associée aux mutations dans la protéine transmembranaire présente sur la vacuole digestive du parasite, désigné PfCRT. De plus, la ou les fonctions normales et substrats naturels de la protéine PfCRT restent une affaire de spéculation étant donné qu'une évidence directe des fonctions normales et des substrats de cette protéine sont encore à déterminer. Les objectives de cette thèse sont de développer et de caractériser deux antisérums de l'extrémité N- et C-terminale de PfCRT comme outils d'identification des protéines interagissant avec la protéine PfCRT de P. falciparum. Bien que la masse moléculaire de la protéine PfCRT était estimée à 48.67 kDa, des caractérisations immunobiochimiques utilisant différents antisérums dirigés contre les domaines cytosoliques N- et C-terminal de cette protéine et publiés à travers la littérature ont abouti à des masses moléculaires variable de la protéine PfCRT sur le SDS PAGE. Dans cette thèse, nous reportons la génération et la caractérisation biochimique de deux antisérums dirigés contre les domaines cytosoliques N- et C de PfCRT. Nos résultats montrent que l'antisérum C de PfCRT détecte les épitopes non-phosphorylés ou des séquences dans la protéine PfCRT. En outre, nos résultats de la cartographie à haute résolution de l'épitope confirment la spécificité de l'antisérum C de PfCRT à la forme non-phosphorylé de PfCRT et montrent que la phosphorylation à deux sites au niveau de la séquence de la protéine, Ser411 et Thr416, qui empêche sa fixation à la protéine complète et phosphorylée. De plus, nous avons identifié une nouvelle forme tronquée de PfCRT qui est à la fois phosphorylée puisqu'elle est reconnue par l'antisérum C de PfCRT, et susceptible de représenter un produit différemment épissé de PfCRT, qui est exprimé in vivo sur la vacuole digestive du parasite. En outre, nos résultats confirment la masse moléculaire de la protéine complète et phosphorylée de PfCRT à 52 kDa sur un SDS PAGE. En utilisant les antisérums de PfCRT combiné à trois méthodes différentes d'interactions protéiques, nous fournissons la première preuve de protéines interagissant avec la protéine PfCRT. L'identification de ces protéines dont la masse varie entre ~20 kDa et 200 kDa est sous enquête active.
Wei, Heng. "Split PH domain identification & redundancy analyses in the classification of PDZ domains /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BICH%202006%20WEI.
Full textHellborg, Fredrik. "Identification, cloning and characterization of the p53 induced gene human wig-1 /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-190-3/.
Full textYap, Jessica. "Identification of Plasmodium falciparum protein kinase substrates and interacting proteins." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/644.
Full textB.S.
Bachelors
Burnett School of Biomedical Sciences
Molecular and Microbiology
Wadahama, Hiroyuki. "Identification and Characterization of Soybean Protein Disulfide Isomerase Family Proteins as Functional Proteins for Folding of Seed-storage Proteins." Kyoto University, 2010. http://hdl.handle.net/2433/120458.
Full text0048
新制・課程博士
博士(農学)
甲第15414号
農博第1799号
新制||農||978(附属図書館)
学位論文||H22||N4513(農学部図書室)
27892
京都大学大学院農学研究科食品生物科学専攻
(主査)教授 河田 照雄, 教授 村田 幸作, 教授 井上 國世
学位規則第4条第1項該当
McLoughlin, D. M. "Identification of proteins interacting with the Alzheimer's disease amyloid precursor protein." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343724.
Full textMac, Partlin Mary. "Identification of proteins interacting with the human mismatch repair protein MLH1." Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/1111/.
Full textHöglund, Pär J. "Identification, Characterization and Evolution of Membrane-bound Proteins /." Uppsala : Acta Universitatis Upsaliensis Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9329.
Full textAlmeida, T. B. "Identification and optimisation of ligands to target protein-protein interactions : EB1-SxIP proteins." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004877/.
Full textPacheco, Sophia A. "Identification of Campylobacter jejuni secreted proteins." Pullman, Wash. : Washington State University, 2010. http://www.dissertations.wsu.edu/Thesis/Spring2010/s_pacheco_021610.pdf.
Full textArianmanesh, Mitra. "Identification of embryo implantation-related proteins." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165845.
Full textTattersall, Daniel. "The identification of retromer partner proteins." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615241.
Full textPrigge, Justin Robert. "Identification and characterization of novel protein-protein interactions with the basal transcription factor, TATA-binding protein." Diss., Montana State University, 2006. http://etd.lib.montana.edu/etd/2006/prigge/PriggeJ0506.pdf.
Full textJing, Yonghua. "Identification of the Na,K-ATP interacting proteins." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1139260222.
Full textLer, Lian Wee. "Identification and characterization of novel mammalian eIF4E-Homologous Protein (4EHP) interacting proteins." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66760.
Full textLa traduction d'un ARNm commence par le recrutement du complexe eIF4F au niveau de la coiffe (ou cap) en 5' de l'ARNm et se complète lors de la reconnaissance du codon d'initiation par le complexe de pré-initiation. La régulation de l'initiation de la traduction est une étape majeure dans le contrôle de l'expression génique. Cette thèse s'intéresse à la protéine humaine 4EHP (h4EHP), un homologue du facteur d'initiation de la traduction se liant à la coiffe, eIF4E. 4EHP peut d'ailleurs s'associer à la coiffe de l'ARNm mais ne peut initier la traduction dépendante de la coiffe. L'homologue chez la drosophile, d4EHP, est un inhibiteur de la traduction de certain ARNm et agit en formant une boucle 5'-3' avec l'ARNm. Les partenaires protéiques de 4EHP définissent alors la spécificité pour l'ARNm. Cette thèse s'intéresse à la fonction de h4EHP en recherchant ses partenaires protéiques. Les trois nouveaux partenaires identifiés (PERQ1, PERQ2 et 4E-T) utilisent un même motif de liaison à h4EHP. Mes expériences démontrent non seulement, que les complexes h4EHP:PERQ1/2 sont impliqués dans la répression de la traduction, mais aussi qu'il existe une co-régulation des niveaux relatifs des protéines h4EHP, PERQ1 et PERQ2. Ce dernier est d'ailleurs dégradé par CUL7 après la déplétion de h4EHP. La protéine 4E-T est connu pour son rôle dans l'inhibition de la traduction, l'import nucléaire d'eIF4E, la formation des « P-Bodies » et le renouvellement des ARNm. Cette étude démontre que h4EHP a une localisation nucléaire et indépendante de 4E-T. La suppression de 4E-T augmente cependant de six fois le nombre de « P-Bodies », sans pour autant affecter le taux de renouvellement d'un ARNm reporteur. En conclusion, cette étude identifie PERQ1 et PERQ2 comme deux inhibiteurs de la traduction dont la fonction et la stabilité sont dépendantes de h4EHP. Cependant, le rôle de l'inter
Ritchie, Sian. "Identification of cytoskeletal proteins as substrates for Ca'2'+ dependent protein kinase." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240317.
Full textAlzahrani, Ashwag. "Identification of Human Proteins Interacting with the Protein IcsB of Shigella flexneri." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38333.
Full textSleeman, Katrina. "Identification of proteins interacting with the polymerase (L) protein of rinderpest virus." Thesis, University of Warwick, 2003. http://wrap.warwick.ac.uk/79583/.
Full textGallia, Jason. "Protein identification by dynamic programming." Diss., Online access via UMI:, 2009.
Find full textFang, Neng. "Good riddance to bad proteins : identification of novel protein quality control pathways targeting cytosolic misfolded proteins for degradation." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46513.
Full textChun, Stella Soyoung. "Identification and validation of CDK13 interacting proteins." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43130.
Full textEvans, R. Jane. "Identification and characterisation of RP2 interacting proteins." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444192/.
Full textWong, Yee-man Elaine, and 王怡雯. "Identification and characterization of VCY2 interacting proteins." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31228008.
Full textRoux, Milena. "Identification and characterization of EFR-interacting proteins." Thesis, University of East Anglia, 2010. https://ueaeprints.uea.ac.uk/26674/.
Full textRenner, Sonja. "Identification of ADAM10 5`UTR binding proteins." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-170738.
Full textHanley, Jonathan Gordon. "Identification of GABAâ†C receptor interacting proteins." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392909.
Full textMelillo, Amanda Adeline. "Identification of Francisella tularensis Outer Membrane Proteins." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1121867713.
Full textRyan, Niamh Marie. "Identification and charactisation of brcai interacting proteins." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492495.
Full textPowell, Karen L. "Identification of type 1 diabetes-related proteins." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27408.
Full textHou, Yuqing. "Identification and Characterization of Components of the Intraflagellar transport (IFT) Machinery: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/323.
Full textZhou, Yiqing, and 周怡青. "Identification of a cellular target of triptonide and its functional study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46923561.
Full textElston, Robert Conrad. "Identification of cellular proteins which interact with the human papillomavirus E6 proteins." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627096.
Full textDagvadorj, Bayantes. "Identification Of Proteins Interacting With Tagged-pathogen Effector Protein In Agro-delivered Planta." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614553/index.pdf.
Full textZhang, Xiao Xiao. "Identification of membrane-interacting proteins and membrane protein interactomes using Nanodiscs and proteomics." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39413.
Full textGinter, Joy M. "Protein identification and characterization by mass spectrometry." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 133 p, 2008. http://proquest.umi.com/pqdweb?did=1597617911&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Full textCowan, Jon Walter. "Proteolysis and the growth hormone receptor identification and characterization of GHR as a [gamma]-secretase substrate /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/cowan.pdf.
Full textLong, Kimberly Renee. "Identification and Characterization of Agv1, a Pre-Metazoan Arf GAP: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/339.
Full textHöglund, Pär J. "Identification, Characterization and Evolution of Membrane-bound Proteins." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9329.
Full textSatijn, David Pierre Elisabeth. "Identification and characterization of human polycomb-group proteins." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/82593.
Full textFerguson, Alison. "Identification and characterisation of Arabidopsis ER accessory proteins." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12472/.
Full textShah, Bindiya. "Identification of genes encoding secreted proteins of schistosomes." Thesis, University of York, 2000. http://etheses.whiterose.ac.uk/9801/.
Full textKimura, Atsuko. "Isolation and identification of imidazoline-2 binding proteins." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399960.
Full textMacer, Darryl Raymund Johnson. "Identification and analysis of proteins of the reticuloplasm." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330298.
Full textLassen, Matthew Gordon. "Identification of proteins involved in chloroplast DNA replication /." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd633.pdf.
Full textLassen, Matthew G. "Identification of Proteins Involved in Chloroplast DNA Replication." BYU ScholarsArchive, 2004. https://scholarsarchive.byu.edu/etd/221.
Full textLi, Zhaobo. "Identification of degradation pathways for HSP90 client proteins." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/67006/.
Full textCotrim, Cândida Zita dos Santos. "Identification of neuronal proteins that interact with PP1y2." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/4508.
Full textA proteína fosfatase 1 (PP1) está envolvida em múltiplos processos de grande relevância fisiológica (por ex. aprendizagem, memória e neurotransmissão) e patológica (envelhecimento, doenças neurodegenerativas). No entanto, restam ainda por estabelecer importantes interacções de relevância fisiológica, bem como a localização intracelular onde estas interacções ocorrem. Esta complexidade é originada pela existência de três isoformas da PP1, organizadas tanto espacialmente como temporalmente e que podem alterar a sua localização intracelular de forma dinâmica. Este projecto focalizou a identificação de proteínas expressas em cérebro humano que interagem com PP1γ2, através da técnica Dois Híbrido em leveduras. Através desta técnica foram obtidos 317 clones positivos, permitindo a identificação de 298 proteínas que ligam à PP1γ2 e 19 proteínas que ligam PP1γ2end, entre as quais algumas proteínas já conhecidas por interagirem com a PP1, outras nunca antes associadas com a PP1 e várias proteínas não caracterizadas. Foi feito um estudo mais detalhado para três proteínas das mais abundantes, PINK1, BRI2 e BRI3. A ligação destas proteínas com PP1 foi analisada através de várias técnicas e a sua localização subcelular e co-localização com a PP1γ e APP foi estudada por imunocitoquímica. Os resultados aqui apresentados corroboram a localização subcelular destas proteínas e a ligação já descrita entre a APP e BRI2. Permitem acrescentar que PINK1, BRI2 e BRI3 interagem com PP1γ e que não só a proteína BRI2 mas também a BRI3 interagem com APP. Estudos futuros serão necessários para compreender o papel destas interacções no sistema neuronal. Estes resultados também validam o uso do sistema YTH como um meio de estudo para melhor compreender as funções da PP1 e sua regulação em diferentes eventos celulares.
The ubiquitous protein phosphatase 1 (PP1) is involved in multiple processes of great physiological (e.g. learning, memory and neurotransmitter signaling) and pathological (aging, Alzheimer’s disease and other neurodegenerative conditions) relevance. However, many physiologically important interactions remain to be established, as well as the exact intracellular locations where these interactions take place. This complexity is provided by the existence of three PP1 isoforms that are organized both spatially and temporally, and can change their intracellular localization dynamically. This project focused on the identification of the PP1γ2 interacting proteins expressed in human brain using the Yeast Two-Hybrid system. With this technique 317 positive clones were recovered allowing the identification of 298 proteins that bind PP1γ2 and 17 proteins that bind PP1γ2end, among those are some previously known PP1 interacting proteins, other proteins never associated with PP1 before and several uncharacterized proteins. A more detailed study was carried out for three of the most abundant clones in the screen, PINK1, BRI2 e BRI3. The binding to PP1 was analyzed by several techniques and its subcellular localization and co-localization with PP1γ and APP studied by immunocytochemistry. These results corroborate the subcellular localization of this proteins and the interaction of BRI2 with APP already described. These results allow concluding that PINK1, BRI2 and BRI3 interact with PP1 and that BRI2 and BRI3 interact with APP. Further studies are needed to understand the function of the interaction of PP1 and PINK1, BRI2 and BRI3 in the neuronal system. Moreover, our results support the use of the YTH system as a means to study and understand PP1 function and regulation in different cellular events.
Das, Lala Meenakshi. "Identification of Endogenously Biotinylated Proteins in Mammalian Spermatozoa." Kent State University Honors College / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1303846044.
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