Dissertations / Theses on the topic 'Protein kinase'
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Gatesman, Ammer Amanda. "PKCalpha direct cSrc activation and podosome formation through the adaptor protein AFAP-110." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3762.
Full textTitle from document title page. Document formatted into pages; contains vii, 350 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 322-346).
Cheng, Kwan-wai. "Regulation of equilibrative nucleoside transporter-1 by protein kinase C and mitogen-activating protein kinase /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31494912.
Full textWang, Jingwei. "Alterations in protein kinase A and protein kinase C activities and protein levels in cardiomyopathy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0001/MQ32280.pdf.
Full textHolland, Pamela M. "Identification, interactions, and specificity of a novel MAP kinase kinase, MKK7 /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9262.
Full textChen, Dan. "Regulation of protein kinase C by protein-protein interactions /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112821.
Full textBenjamin, Audra Ruth. "Lung liquid homeostasis : The involvement of protein kinase A and protein tyrosine kinase." Thesis, St George's, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511892.
Full textKerkelä, R. (Risto). "Signaling pathways in myocyte hypertrophy:role of GATA4, mitogen-activated protein kinases and protein kinase C." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269950.
Full textCheng, Kwan-wai, and 鄭軍偉. "Regulation of equilibrative nucleoside transporter-1 by protein kinaseC and mitogen-activating protein kinase." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45009983.
Full textToker, I. Alex. "Purification and characterisation of protein kinase C inhibitor proteins." Thesis, University College London (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277909.
Full textWalker, Valerie Glynis. "Pl3-kinase mediates cSrc activation and podosome formation through the adaptor protein, AFAP-110, in response to PKC[alpha] activation." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5191.
Full textTitle from document title page. Document formatted into pages; contains viii, 306 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Braz, Julian C. "Protein Kinase Ca & p38 protein kinase In heart failure: old stories, new players /." Cincinnati, Ohio : University of Cincinnati, 2006. http://www.ohiolink.edu/etd/view.cgi?ucin1147723239.
Full textAdvisor: Dr. Jeffery D Molkentin Title from electronic thesis title page (viewed Nov. 23, 2007). Includes abstract. Includes bibliographical references.
BRAZ, JULIAN C. "Protein Kinase Cα & p38 Protein Kinase In Heart Failure: Old Stories, New Players." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147723239.
Full textWaskiewicz, Andrew Jan. "Mitogen-activated protein kinase : evolutionary conservation and activation of downstream kinases /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/9216.
Full textRojnuckarin, Ponlapat. "Mitogen-activated protein kinase pathways in megakaryocyte development /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9200.
Full textPenfold, Lucy. "Investigating the roles of AMP-activated protein kinase and calcium/calmodulin-dependent protein kinase kinase β in prostate cancer." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/54390.
Full textHolland, Zoe. "Plasmodium falciparum protein kinase CK2." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/606/.
Full textRobinson, Karen Ann. "Protein regulators of kinase C." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282756.
Full textMatthews, Sharon. "Regulation of protein kinase D." Thesis, University College London (University of London), 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716241.
Full textDavis, Alison Jane. "Kinase-anchoring proteins and the intracellular targeting of cyclic adenosine monophosphate (cAMP)-dependent protein kinase." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29960.
Full textCherezova, Lidia Nikolayevna. "Determining the effects of phosphorylation on AFAP-110 function." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2492.
Full textTitle from document title page. Document formatted into pages; contains v, 105 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Chan, Ka-wai, and 陳嘉威. "Characterization of a physiological 62-kDa protein substrate for ganglioside-stimulated protein kinase in central nervous systemmyelin." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30595575.
Full textMaitra, Sushmit. "The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase activated protein kinase 2." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008r/maitra.pdf.
Full textDettori, Rosalia Angela [Verfasser], and Albrecht [Akademischer Betreuer] Piiper. "Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) / Rosalia Angela Dettori. Betreuer: Albrecht Piiper." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2011. http://d-nb.info/1051285267/34.
Full textDettori, Rosalia Angela [Verfasser], and Albrecht [Akademischer Betreuer] Piiper. "Regulation of the interaction between protein kinase C-related protein kinase 2(PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) / Rosalia Angela Dettori ; Betreuer: Albrecht Piiper." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1131628934/34.
Full textStreicher, John Michael. "The role of mitogen activated protein kinase activated protein kinase-2 in regulating p38 mitogen activated protein kinase induced cyclooxygenase-2 induction and heart failure." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872200951&sid=6&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Full textYap, Jessica. "Identification of Plasmodium falciparum protein kinase substrates and interacting proteins." Honors in the Major Thesis, University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/644.
Full textB.S.
Bachelors
Burnett School of Biomedical Sciences
Molecular and Microbiology
Dutil, Erica M. "Phosphorylation of protein kinase C by the phosphoinositide-dependent kinase /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9961757.
Full textMills, Julia. "Regulation of amyloid precursor protein catabolism in vitro, the role of mitogen-activated protein kinase and protein kinase C." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq27201.pdf.
Full textHurst, Denise. "AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance trained rats." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2014.pdf.
Full textYoung, Stephen W. "The insulin receptor tyrosine kinase and the activation of the map kinase cascade : interactions with the protein kinase C and protein kinase A signalling pathways." Thesis, University of Bristol, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238958.
Full textSmart, Nicola. "Studies on the mechanism of protein kinase C down-regulation." Thesis, Royal Veterinary College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391675.
Full textKotwaliwale, Chitra V. "Regulation and functions of the Ipl1/aurora protein kinase /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5081.
Full textLala, Hitesh Nagin. "Subcloning of calcium-dependent protein kinase related kinase homologues in arabidopsis thaliana." Thesis, Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/25343.
Full textNurimba, Margaret. "Roles of SR protein kinase Dsk1 and LAMMER kinase Kic1 in mRNA processing in fission yeast, Schizosaccharomyces pombe." Scholarship @ Claremont, 2014. http://scholarship.claremont.edu/scripps_theses/305.
Full textBeeton, Carolyn Ann. "Functional differences of class 1a PI 3-kinase heterodimers." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322073.
Full textBrancho, Deborah Marie. "Regulation and Function of Stress-Activated Protein Kinase Signal Transduction Pathways: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/101.
Full textChen, Mingzi. "Mos regulation in activating the MAP kinase pathway /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9195.
Full textLuhovy, Artem. "The activation of protein kinase SLK." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97038.
Full textUne expression, une localisation ou une activation inappropriée des protéines kinases rénales peut provoquer une dysplasie rénale ou une maladie cystique prématurée. L'expression et l'activation de la protéine Ste20-like kinase (SLK) sont plus élevées pendant le développement des reins et durant la guérison d'une insuffisance rénale ischémique aiguë. Une activation de la protéine SLK entraîne l'apoptose des cellules in vitro et in vivo. Au cours du développement et de la régénérescence cellulaire, SLK peut réguler la croissance cellulaire. Par contre, dans les glomérulonéphrites, l'activation de la SLK et une apoptose des cellules épithéliales glomérulaires (GEC) peuvent être dommageables et peuvent provoquer des lésions glomérulaires sclérotiques. L'objectif de ce projet est d'élucider la régulation de l'activité de la SLK dans le but de mieux comprendre son rôle dans le développement et les lésions ou maladies glomérulaires rénales. Ce projet postule que l'activation de la protéine SLK peut être due à une régulation à la hausse de l'expression, qui peut alors favoriser une homodimérisation et une autophosphorylation. Pour étudier le rôle de la phosphorylation dans la régulation de l'activation, les résidus sérine (S189) et thréonine (T183) ont été mutés dans le segment putatif du domaine catalytique de la SLK. Deux mutants simples (T183A et S189A) et un double mutant (T183A/S189A) ont été créés. La forme sauvage (WT) et les mutants de la SLK ont été exprimés dans les cellules cos-1 et GEC. SLK WT phosphorylais la protéine basique de myéline (MBP) contrairement aux mutants S189A et T183A/S189A qui montraient une activité kinase in vitro non significative. La mutation T183A diminuait la phosphorylation de MBP significativement. L'analyse des voies de signalisation de la kinase N-terminal c-jun (JNK) et de la p38 par la SLK a été étudiée sachant que l'expression de la SLK WT stimule la phosphorylation de la JNK et de la p38. Tant que T183A/S189A n'a pas pu activer la JNK et la p38, les mutants T183A et S189A ont activé la JNK à un degré moindre que la SLK WT. Ces résultats démontrent que la phosphorylation de T183 et de S189 est importante pour l'activation de la SLK. De façon similaire, l'expression de la SLK WT a stimulé l'activation de la protéine activatrice 1 (AP1), un facteur de transcription de la famille c-fos et c-Jun, tandis que les trois mutants ont été incapables de stimuler AP1. Pour déterminer si l'homodimérisation de la SLK affecte la phosphorylation, l'ADN complémentaire de la SLK codant le domaine catalytique (1-373) a été fusionné avec l'ADN complémentaire d'une protéine modifiée qui s'attache à des molécules FK506 (Fv), pour créer SLK-Fv. Après la transfection, l'addition du AP20187, un analogue de FK506, induit la dimérisation de la SLK-Fv. La dimérisation occasionnée par l'AP20187 a augmenté l'activité catalytique de la SLK-Fv. Par contre, tous les mutants Fv fusionnés T183A/S189A, E79A, K63R et T193A démontraient une activité catalytique faible, que la dimérisation n'a pas pu augmenter. Ce qui est particulièrement intéressant, les mutants phosphomimétiques T183D, T183E, S189D et S189E montraient aussi une activité catalytique faible qui n'a pas été affectée par la dimérisation. Finalement, l'apoptose et la nécrose sont accrues suite à une surexpression de la SLK-Fv WT, mais pas avec le mutant T183A/S189A-Fv. Ainsi, les acides aminés K63 et E79 et la phosphorylation de T183, S189 et T193 jouent un rôle important dans la régulation de la SLK et pourraient être ciblés par des approches thérapeutiques pour le traitement des néphropathies.
Stafford, Margaret Jackson. "Protein kinase C in platelet signalling." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275204.
Full textMurphy, John Anthony. "The protein kinase C of glia." Thesis, University of York, 1989. http://etheses.whiterose.ac.uk/9762/.
Full textRessurreicao, Margarida de Azevedo Gomes de Carvalho. "Protein kinase signalling in Schistosoma mansoni." Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/28771/.
Full textHocevar, Barbara Ann. "Characterization of nuclear protein kinase C." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1057177248.
Full textKumar, Varun. "Protein Kinase C Signaling in Neurodegeneration." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1455721051.
Full textEdwards, Amelia S. "Interdomain regulation of protein kinase C /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9901441.
Full textDennis, Patrick B. (Patrick Brian). "Autophosphorylation and Autoactivation of an S6/H4 Kinase Isolated From Human Placenta." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc279364/.
Full textHynes, Andrews Mark. "Rx-kinase and protein kinase C in superoxide production from neutrophils." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267858.
Full textFoukas, Lazaros. "Defining the physiological role of phosphatidylinositol 3-kinase protein kinase activity." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397223.
Full textBrown, Jacob D. "Liver Kinase B1/AMP-Activated Protein Kinase Signaling in the Diaphragm." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2543.
Full textGoodman, Alan Gabriel. "P58IPK, the cellular eIF2alpha kinase inhibitor, promotes viral mRNA translation and limits host death during influenza virus infection /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8082.
Full textBaisden, Joseph M. "AFAP-110 is a cSrc activator." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2766.
Full textTitle from document title page. Document formatted into pages; contains v, 149 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.