Relevant bibliographies by topics / Prospective injury association

Academic literature on the topic 'Prospective injury association'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Prospective injury association"

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Maujean, Annick, David Shum, and Rachel McQueen. "Effect of Cognitive Demand on Prospective Memory in Individuals with Traumatic Brain Injury." Brain Impairment 4, no. 2 (December 1, 2003): 135–45. http://dx.doi.org/10.1375/brim.4.2.135.27024.

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AbstractThis study aimed to evaluate the influence of cognitive demand on prospective-memory in individuals with traumatic brain injury (TBI) using a dual-task paradigm. Fourteen individuals with severe TBI and 14 matched controls were required to undertake two tasks. A lexical-decision task was used as an ongoing task and had two levels of cognitive demand (viz., low and high). The event-based prospective-memory task involved performing a specific action whenever a target stimulus appeared during the ongoing task. The Letter-Number Sequencing Test, the Tower of London and the Controlled Oral Word Association Test were also administered to assess the relationship between prefrontal lobe functions and prospective memory. As hypothesised, participants in the TBI group performed more poorly than participants in the control group on the prospective-memory task in the high but not in the low demand condition. There were significant correlations between prospective-memory task performance and scores on the Letter-Number Sequencing Test and the Controlled Oral Word Association Test. These findings help to clarify the nature of prospective-memory impairment in individuals with TBI and support the involvement of prefrontal processes in prospective remembering.
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Ali Ramadan, Asmaa. "Prospective study of the association of coagulopathy and isolated traumatic brain injury." Biolife 3, no. 2 (May 27, 2015): 514–18. http://dx.doi.org/10.17812/blj2015.32.23.

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Marshall, R. E., J. S. Milligan-Saville, Z. Steel, R. A. Bryant, P. B. Mitchell, and S. B. Harvey. "A prospective study of pre-employment psychological testing amongst police recruits." Occupational Medicine 70, no. 3 (February 10, 2020): 162–68. http://dx.doi.org/10.1093/occmed/kqaa008.

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Abstract Background Pre-employment psychological screening to detect psychological vulnerability is common amongst emergency service organizations worldwide, yet the evidence for its ability to predict poor mental health outcomes is limited with published studies looking at post-recruitment research data rather than data collected by the organizations themselves. Aims The present study sought to investigate the ability of pre-employment screening to predict later psychological injury-related absenteeism amongst police officers. Methods A nested case–control study using prospective data was conducted. One hundred and fifty police officers with a liability-accepted psychological injury were matched to a control group of 150 psychologically healthy officers. Conditional logistic regression was used to examine associations between Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales measuring factors research has shown to predict psychological injury (Neuroticism, Psychoticism, Introversion, Disconstraint and Aggressiveness) and psychopathology (Depression, Anxiety and post-traumatic stress disorder [PTSD]) with subsequent psychological injury. Results Contrary to expectations, we were unable to demonstrate any association between validated pre-employment measures of personality and psychopathology with mental health outcomes amongst newly recruited police officers over a 7-year follow-up. Conclusions Other measures may be better able to predict future mental health problems in police recruits.
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Carreira, Dominic S., Daniel B. Shaw, Thomas G. Harris, Kirk A. McCullough, Christopher D. Kreulen, RobRoy Martin, and Jorge I. Acevedo. "Osteochondral and Ligament Injury Patterns in Ankle Fractures: A Prospective Multi-Center Study." Foot & Ankle Orthopaedics 7, no. 2 (April 2022): 2473011421S0052. http://dx.doi.org/10.1177/2473011421s00523.

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Category: Ankle; Arthroscopy; Sports; Trauma; Other Introduction/Purpose: When treating ankle fractures, the presence of talar osteochondral lesions and the extent of ligamentous injury are associated with the severity of injury. The Danis-Weber classification system has been used to predict potential ligament damage. The purpose of this study is to validate the ligament injury patterns that have been proposed to occur with the Danis-Weber Classification and identify the cartilage injury pattern that occurs on the talus with each fracture type. Methods: A prospective, multi-center foot and ankle arthroscopy registry was queried for patients who underwent arthroscopic treatment of ankle fractures. Preoperative and intraoperative findings were noted, including the Danis-Weber fracture classification, presence and location of osteochondral damage, and unstable deltoid, and/or syndesmotic ligaments. Kendall's tau-b, a nonparametric correlation coefficient for ordinal variables, was used to measure the strength and direction of association between Weber fracture type and the presence of a syndesmotic injury, deltoid ligament tear, medial malleolus fracture, or osteochondral lesion. The locations of osteochondral damage were compared as percentages. Results: 73 subjects were prospectively collected as part of a multicenter ankle arthroscopy database. Average subject age was 43 years (SD = 17) with 59% female and 41% male. A significant association between the presence of a syndesmotic injury and fracture type was identified, with syndesmotic injuries more likely occurring with a Weber C fracture (p < 0.0005). A significant association was not identified between Weber classification and a deltoid tear or medial malleolus fracture (p = 0.47, p = 0.79). Location of the talar osteochondral lesions were as follows: 22% medial-anterior, 22% lateral-anterior, 22% lateral-central, 17% central-anterior, 9% medial-central, 4% later-posterior, 4% central. There was no significant association identified between Weber classification and the location of the osteochondral injury (p = 0.99). Conclusion: Concurrent injuries with syndesmotic disruption, deltoid ligament tears, medial malleolus fractures, and osteochondral lesions have been proposed to be associated with Weber C ankle fractures. However, in this multicenter study, only syndesmotic injuries were associated with the Weber C classification. This study found similar rates of medial malleolus fractures and osteochondral lesions in Weber B and C type fractures.
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Biswakarma, Pushpa, and Punam Limbu. "Dural Injury During Placement of Burrholes- Single Center Study." Eastern Green Neurosurgery 2, no. 1 (January 29, 2020): 35–37. http://dx.doi.org/10.3126/egn.v2i1.27460.

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Background and purpose: Dural tear is one of the unpleasant complications for the neurosurgeon during craniotomy. The injury might be outer dural injury or complete dural tear in nature. With the objective to see the frequency of dural injury and to analysis the association factor this study was performed prospectively. Material and method: This is a Prospective analytical study over the duration of 2 months. All the consecutive patients, who operated for neurosurgical pathologies where drill burr was necessary, were included in this study. Association between age, gender, diagnosis category and number of burrs and dural injury was done using Fischer’s exact test or correlation whenever necessary. Result: There were total of 19 patients enrolled in the study with mean age of patient in this study was 49.11 (S.D 17.13) years. Majority of them were male (79%) and head injury (47%) was the commonest pathology in the study. correlation between number of burr and dural tear was significant Conclusion: There was no significant correlation between age and dural injury. However, significant correlation was seen between number of burr holes made during the procedure with dural injury.
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Guan, Yanfei, Shannon S. D. Bredin, Jack Taunton, Qinxian Jiang, Nana Wu, and Darren E. R. Warburton. "Association between Inter-Limb Asymmetries in Lower-Limb Functional Performance and Sport Injury: A Systematic Review of Prospective Cohort Studies." Journal of Clinical Medicine 11, no. 2 (January 12, 2022): 360. http://dx.doi.org/10.3390/jcm11020360.

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Background: Inter-limb asymmetry in lower-limb functional performance has been associated with increased risk of sport injury; however, findings are not always consistent. Purpose: To conduct a systematic review on whether inter-limb asymmetry in lower-limb functional performance can predict sport injury. Methods: Four electronic databases (MEDLINE, EMBASE, Web of Science, and SportDiscus) were systematically searched for prospective cohort studies reporting the association between inter-limb asymmetry in lower-limb functional performance and sport injury. Results: A total of 28 prospective cohort studies were included in the analyses. Collectively, the findings were highly inconsistent, and a clear statement on the association between each asymmetry and sport injury was difficult. Conclusions: Highly inconsistent findings make it difficult to create clear recommendations on the relationship between the inter-limb asymmetry in lower-limb functional performance (power, muscle flexibility, and dynamic balance) and sport injury. The influence of potential factors (selection of tests/parameters, participant characteristics, definition of injury, and ways of calculating asymmetry) should be considered when using previous findings.
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FLEMING, JENNIFER, LEE RILEY, HANNAH GILL, MATTHEW J. GULLO, JENNY STRONG, and DAVID SHUM. "Predictors of prospective memory in adults with traumatic brain injury." Journal of the International Neuropsychological Society 14, no. 5 (September 2008): 823–31. http://dx.doi.org/10.1017/s1355617708080971.

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Previous studies have established that prospective memory is commonly affected following traumatic brain injury (TBI). This study examines whether demographic factors, injury severity and site, executive function, and metacognitive factors predict prospective memory performance in adults with TBI, using a cross-sectional multivariate correlational model. Prospective memory of 44 adults (mean age = 30 years) with severe TBI was measured by the Cambridge Prospective Memory Test (CAMPROMPT) time-based and event-based scores. Using stepwise multiple regression, the time-based score was predicted by the Controlled Oral Word Association Test (COWAT) Animals subtest score, length of post-traumatic amnesia (PTA) and use of note-taking on the CAMPROMPT. The event-based score was predicted by length of PTA and COWAT Animals score. Therefore, patients with longer periods of PTA and executive function impairment may be expected to display poorer prospective memory. Note-taking was associated with improved performance on time-based prospective memory tasks. (JINS, 2008,14, 823–831.)
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Son, Boae, Young Jae Cho, Hee Seong Jeong, and Sae Yong Lee. "Injuries in Korean Elite Taekwondo Athletes: A Prospective Study." International Journal of Environmental Research and Public Health 17, no. 14 (July 16, 2020): 5143. http://dx.doi.org/10.3390/ijerph17145143.

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This prospective cohort study aimed to identify the incidence and characteristics of Taekwondo-related injuries according to age, sex, and event type (i.e., practice or competition) based on a web-based injury surveillance system (ISS) with a follow-up period of 12 months. A total of 285 members of the Korea Taekwondo Association who competed in the 2016 season participated. Injury incidence rates (IRs) were calculated per 1000 athlete-exposures (AEs). Injury rate ratios (RRs) with 95% confidence intervals were calculated and compared regarding age, sex, and event type. During the season, 336 injuries were reported, resulting in a rate of 6.31/1000 AEs. The most common location, type, and mechanism of injury in Taekwondo athletes were the foot/ankle, ligament sprain, and contact with another player, respectively. The overall injury IRs associated with Taekwondo practicing and competition were 4.79/1000 AEs and 24.86/1000 AEs, respectively. The overall injury RR related to both practice and competition was higher in youth athletes than in adult athletes. However, adult athletes were more likely to sustain more severe injuries. Korean elite Taekwondo athletes were commonly exposed to injury, especially youth and female athletes. Therefore, continuation of the ISS suggests the development of interventions for preventing injuries sustained by Taekwondo athletes.
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Pletsch-Borba, Laura, Mirja Grafetstätter, Anika Hüsing, Theron Johnson, Sandra González Maldonado, Marie-Luise Groß, Manja Kloss, et al. "Vascular injury biomarkers and stroke risk." Neurology 94, no. 22 (May 5, 2020): e2337-e2345. http://dx.doi.org/10.1212/wnl.0000000000009391.

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ObjectiveBecause little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study.MethodsA case–cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition–Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Weighted Cox regression analyses were used to assess associations between biomarker levels and stroke risk.ResultsMedian follow-up in the subcohort and among cases was 9.8 (range, 0.1–12.5) years and 6.2 (range, 0.01–12.1) years, respectively. ICAM3 levels were associated with increased risk of incident stroke after multivariable adjustment (hazard ratio, highest vs lowest quartile: 1.64 [95% confidence interval, 1.15–2.32]; plinear trend < 0.001). This association was more apparent for ischemic (1.65 [1.12–2.45]; plinear trend < 0.01) than for hemorrhagic stroke (1.29 [0.60–2.78]; plinear trend = 0.3). We further observed a borderline significant trend for a positive association between sTM and overall stroke risk (1.47 [0.99–2.19]; plinear trend = 0.05).ConclusionsIn this population-based study, circulating levels of ICAM3, an adhesion molecule shed by leukocytes, were associated with increased risk of incident stroke. Further mechanistic studies are needed to elucidate the pathophysiology underlying this association.Classification of evidenceThis study provides Class II evidence that plasma levels of ICAM3 are associated with increased stroke risk.
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Mohanavalli, S., E. Suma, G. Senthamarai, and G. Sree Vijayabala. "Ocular Injuries in Association with Middle Third Facial Injuries in Developing Countries: A Prospective Study." World Journal of Dentistry 7, no. 3 (2016): 135–40. http://dx.doi.org/10.5005/jp-journals-10015-1382.

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ABSTRACT Introduction The middle third of the face is the most common site of injury and is frequently complicated by associated ocular injuries. It may be simple laceration, ecchymosis, circumorbital edema, or severe as globe injury or injury to the optic nerve and vision loss. Even severe injury like internal bleeding causes increased intraocular pressure and damages the optic nerve; if managed earlier, it could prevent further damage and dysfunction of the eye. Midfacial fractures associated with ocular injuries should have an early ophthalmological examination to detect ocular injuries. Little is known about the current epidemiology of midface fractures and associated ocular injuries in Tamil Nadu, the state of India. The aim was to study the etiology and pattern of middle third fracture and associated ocular injuries. Materials and methods This prospective study on midface fractures was carried out in the Department of Dentistry to analyze etiology, incidence, and patterns of midface fractures and associated ocular injuries. A total of 201 patients who reported with the history of midface injuries were included in the study. These patients were examined clinically and routine radiographs and computerized tomography magnetic resonance imaging (MRI) were taken to confirm the diagnosis. All the patients sustaining confirmed middle third fractures with or without eye signs were referred to an ophthalmology department for the evaluation and management of associated ophthalmic injury. Statistical Package for the Social Sciences software version 16.0 was used for data analysis. The outcome of the study was measured using percentages, mean, standard deviation, and test of proportion as appropriate. Results Traffic accident was the major cause of injury, mainly by motorized two wheelers (MTWs). Males in the 21 to 40 age group were common victims. Zygomatic complex fracture was the most common fracture type. Subconjunctival hemorrhage and infraorbital nerve injuries were common clinical findings. Conclusion Midthird facial injury cases should have an early ophthalmological examination for timely management to prevent dysfunction of the eye. How to cite this article Mohanavalli S, Suma E, Senthamarai G, Vijayabala GS. Ocular Injuries in Association with Middle Third Facial Injuries in Developing Countries: A Prospective Study. World J Dent 2016;7(3):135-140.
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Book chapters on the topic "Prospective injury association"

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Ellis, Margaret K. Menzel, and Ansgar Brambrink. "Neurotoxicity of General Anaesthetics." In Oxford Textbook of Neuroscience and Anaesthesiology, edited by George A. Mashour and Kristin Engelhard, 93–110. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198746645.003.0008.

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This chapter covers the neurotoxicity of general anaesthetics. It discusses how a large body of preclinical evidence shows an association of anaesthetic exposure with neural cell injury and death in the developing brain. Several putative mechanisms have been demonstrated in vitro and in in vivo animal models. Furthermore, these exposures have been associated with impaired behavioural and cognitive development in young animals. Several retrospective human studies of neurocognitive and behavioural disorders following childhood exposure to anaesthesia suggest a similar association, and prospective studies in humans are currently ongoing. The implication of this information on anaesthetic practise remains to be seen.
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"Since blood transfusion is linked to the magnitude of the surgical procedure, comparing transfused patients to untransfused patients will always be confounded by infection risks due to factors related to the procedure. To control for these factors one must compare patients transfused with red cells from different sources or prepared in a manner which minimize infection risk. Patients transfused with homologous blood have infection rates several fold higher than recipients of equal values of autologous blood undergoing the same operative procedure (20-23). Homologous blood recipients have significantly longer hospital stays attributed to treating infections. The cost of a blood transfusion exceeds the cost of collection, storage and administration because of transfusion's association with length of stay. In this era of cost-containment the association with prolonged stay may ultimately curtail the use of blood. Homologous blood can be filtered to remove donor leukocytes which may be contributing to immune suppression and infection risk. A prospective randomized trial comparing the infection rates among colorectal cancer patients receiving filtered and unfiltered blood has been conducted (9). There were 17 infectious complications among the 56 recipients of whole blood and one infectious complication among the 48 recipients of filtered blood. Infections were prevented by the seemingly simplistic addition of a $25/filter to every bag of blood transfused. These clinical studies are very convincing: homologous blood transfusion is associated with increased risk of infection in every clinical situation examined. In multivariate analyses transfusion was a significant predictor of infection after consideration of other variables measured and in the majority of those studies transfusion was the single most significant factor. Patients receiving homologous blood exhibited an incidence of infectious complications that was approximately four times higher than patients receiving autologous blood. The association of transfusion with infection is found among patients undergoing surgery for cardiac, orthopedic and gastrointestinal disorders and for trauma as well as among unoperated patients transfused for bums and gastrointestinal bleeding. The observation that nosocomial infections are increased in these studies argues strongly that the association of transfusion with infection is not simply a reflection of transfusion as a marker of tissue destruction and contamination. Infections that develop in transfused patients away from the site of trauma or in the absence of trauma, cannot be attributed to the quantity of tissue destroyed or to the degree of bacterial contamination. Filtered blood can remove leukocytes and prevent postoperative infections. Since filtering blood can significantly reduce the incidence of infection among transfused patients, all transfused blood will be passing through filters in the very near future. EXPERIMENTAL STUDIES RELATING BLOOD TRANSFUSION TO INCREASED RISK OF INFECTION Patients are extremely heterogeneous and even in prospective randomized trials, factors which influence patients' participation affect the outcome despite double-blinding and randomization. In animal studies using syngeneic strains with identical housing, lighting, access to food and water, control over the extent of injury, use of antibiotics and exposure to other variables the influence of a single variable such as blood transfusion can be measured. Dr. Waymack's laboratory has intensively studied parameters which interact with transfusion in." In Transfusion Immunology and Medicine, 296. CRC Press, 1995. http://dx.doi.org/10.1201/9781482273441-25.

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Conference papers on the topic "Prospective injury association"

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Wezenbeek, Evi, Sander Denolf, Jan Bourgois, Renaat Philippaerts, Bram De Winne, Erik Witvrouw, Steven Verstockt, and Joke Schuermans. "426 The association between COVID-19 and physical performance in professional football players: a prospective cohort study." In IOC World Conference on Prevention of Injury & Illness in Sport 2021. BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine, 2021. http://dx.doi.org/10.1136/bjsports-2021-ioc.390.

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Wezenbeek, Evi, Sander Denolf, Dries Pieters, Jan Bourgois, Renaat Philippaerts, Bram De Winne, Joke Schuermans, Steven Verstockt, and Erik Witvrouw. "457 The association between COVID-19 and muscle strain injury occurrence in elite soccer players: a prospective study." In IOC World Conference on Prevention of Injury & Illness in Sport 2021. BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine, 2021. http://dx.doi.org/10.1136/bjsports-2021-ioc.418.

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Nordstrøm, Anine, Roald Bahr, Ben Clarsen, and Ove Talsnes. "396 The association between preseason fitness level and risk of injury or illness – a prospective cohort study in male elite ice hockey." In IOC World Conference on Prevention of Injury & Illness in Sport 2021. BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine, 2021. http://dx.doi.org/10.1136/bjsports-2021-ioc.362.

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Fazio, Massimo A., Rafael Grytz, Jeffrey S. Morris, Luigi Bruno, Christopher A. Girkin, and J. Crawford Downs. "Age-Related Changes in the Non-Linear Mechanical Strain Response of Human Peripapillary Sclera." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14748.

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In glaucoma, the optic nerve head (ONH) is the site of damage to the retinal ganglion cell axons that transmit the visual information from the eye to the brain. Results of several randomized prospective trials showed that intraocular pressure (IOP), age 1, increased optic disc cupping, corneal thickness, and African ancestry 2 are independently associated with glaucomatous progression. All of these risk factors have a biologically plausible association with either the level of IOP, the severity of disease, or biomechanical properties of the ONH. Importantly, age is the only risk factor other than IOP that is independently associated with the onset and progression of glaucoma across all of the major prospective clinical trials conducted over the past twenty years. In addition, every population-based survey conducted to date has demonstrated a strong relationship between the prevalence of glaucoma with advancing age, despite almost no studies showing IOP changes with age. These findings indicate that the aging ONH becomes increasingly vulnerable to glaucomatous injury at similar levels of IOP.
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Zanetta, DMT, EA Burdmann, and FAF Melo. "P61 Incidence, risk factors and prognose of acute kidney injury in critically ill patients: a prospective cohort study in brazilian amazon." In Society for Social Medicine and Population Health and International Epidemiology Association European Congress Annual Scientific Meeting 2019, Hosted by the Society for Social Medicine & Population Health and International Epidemiology Association (IEA), School of Public Health, University College Cork, Cork, Ireland, 4–6 September 2019. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/jech-2019-ssmabstracts.212.

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Meade, T. W. "THE EPIDEMIOLOGY OF HAEMOSTATIC AND OTHER VARIABLES IN CORONARY ARTERY DISEASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643833.

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The increase in the clinical manifestations of coronary artery disease (CAD) since the 1920s cannot be explained solely in terms of atheroma. Another major process such as thrombogenesis must also be involved. Pathological studies show that thrombosis contributes not only to myocardial infarction but to nearly all cases of sudden coronary death as well. Epidemiologically, it is the coagulation system rather than platelet function that has so far been more rewarding in attempting to identify characteristics of the haemostatic system that are associated with the subsequent risk of CAD. In particular, two clotting factors - factor VII coagulant activity, VIIc, and fibrinogen - may be involved. Factor VII has several characteristics that are required for a system to secure rapid haemostasis after injury. The question is whether an exaggeration of the physiological state of readiness implied by these features may predispose to thrombosis. There are at least four pathways through which high fibrinogen levels, however they are determined, may operate to increase the risk of CAD - involvement in atherogenesis, determination of blood and plasma viscosity, effects on platelet aggregability and an influence on the amount of fibrin formed. The prospective Northwick Park Heart Study (NPHS) has shown an association between high VIIc levels and an increased risk of CAD. NPHS and three other prospective studies have also demonstrated a clear association between high levels of plasma fibrinogen and an increased risk of CAD, this association generally being stronger than for more familiar markers of risk such as the blood cholesterol level. There may well be an interaction between fibrinogen and blood pressure, the occurrence of high levels of both increasing CAD or stroke risk to a greater extent than would be expected from the sum of their separate effects. Several pathological and clinical observations support a “hypercoagulable state” not simply as a concept but as a demonstrable abnormality in which characteristics of the circulating blood influence the course of events. These include the effects of anti-thrombotic agents (particularly oral anticoagulants) on re—infarction rates and the likelihood that high VIIc levels lead to increased levels of thrombin production. The general epidemiology of VIIc and fibrinogen is consistent with the view that high levels of each are of pathogenetic significance. Thus, increasing age, obesity, oral contraceptive usage, the occurrence of the menopause and diabetes are all associated with high levels of VIIc and fibrinogen and with an increased risk of CAD. Psychosocial influences may increase the risk of CAD through effects on the plasma fibrinogen level. There is strong evidence that dietary habit, particularly the consumption of fat, is a leading determinant of the VIIc level. A substantial proportion of the relationship between cigarette smoking and CAD is probably mediated through the plasma fibrinogen level. The most radical implication of a “hypercoagulable state” is for the pharmacological prophylaxis of CAD which, it may turn out, is better approached by anti—thrombotic measures than by the use of lipid-lowering agents.
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Reports on the topic "Prospective injury association"

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Drug-Induced Liver Injury (DILI): Current status and future directions for drug development and the post-market setting. Council for International Organizations of Medical Sciences (CIOMS), 2020. http://dx.doi.org/10.56759/ojsg8296.

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Drug-induced liver injury (DILI) is a growing challenge because of the ever- increasing number of drugs used in medical care. DILI is rare but can be serious and is largely unpredictable. It is an important cause of mortality and liver transplantation, and a leading cause of attrition in drug development. Progress is under way in identifying genetic risk factors, exploring new mechanistic concepts of the complex underlying interactions, and developing new biomarkers that can predict or diagnose DILI. The pharmaceutical industry has a key role in advancing these initiatives, and prospective DILI registries must adopt standard procedures for biological sample collection and storing. There is a strong need for standard guidelines to support these efforts. The consensus report of the CIOMS DILI Working Group aims to provide a critical framework and essential set of tools to detect, diagnose and manage DILI during drug development and in the post-marketing setting. The report is intended for clinical and basic pharmaceutical industry investigators who capture, analyze and communicate liver safety data in drug development. It is also intended for regulatory scientists and expert consultants who comprehensively evaluate new products and emerging biomarkers for their association with DILI risk, and for health care professionals who monitor and manage patients treated with potentially hepatotoxic drugs in clinical practice.
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