Relevant bibliographies by topics / Propofol

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Academic literature on the topic 'Propofol'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 September 2024

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Journal articles on the topic "Propofol"

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Djordjevic, Biljana, Dragana Loncar-Stojiljkovic, Dragan Ivanovic, Gordana Ivanovic, and Milos Stojiljkovic. "Co-induction in outpatient anesthesia." Vojnosanitetski pregled 59, no. 6 (2002): 609–14. http://dx.doi.org/10.2298/vsp0206609d.

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Cilj. Koindukcija u anesteziji je veoma korisna: sinergisticki efekti dva indukciona leka mogu da smanje indukcionu dozu i pojavu nezeljenih efekata. Cilj rada bio je da se ispitaju i uporede dve tehnike anestezije za kratke ginekoloske intervencije u ambulantnim uslovima. Grupa od 80 zena zakazana za hirurski prekid trudnoce podeljena je metodom slucajnog uzorka na dve jednake grupe - kontrolnu i koindukcionu. Metode. Prva grupa dobila je: atropin 0,5 mg, iv., alfentanil 0,5 mg iv. i propofol kao frakcionisani iv. bolus do gasenja refleksa trepavica. Druga grupa je dobila: atropin 0,5 mg, alfentanil 0,5 mg, midazolam 3 mg i propofol na isti nacin kao i prva grupa. Anestezija je odrzavana dodatnim dozama. Registrovani su kardiovaskularni parametri, kvalitet anestezije, nezeljena dejstva i brzina oporavka. Rezultati. Kod osoba koje su dobijale midazolam indukciona doza propofola bila je znacajno niza, dok kardiovaskularni parametri nisu bili znacajno razliciti. Oporavak posle anestezije bio je nakon koindukcije malo duzi, sto nije imalo klinicki znacaj. U koindukcionoj grupi uoceno je smanjenje nezeljenih dejstava. Zakljucak. Rezultati studije pokazali su da u ambulantnoj anesteziji koindukcija kombinacijom midazolam-propofol u poredjenju sa propofolom ima sledece prednosti: smanjenje doze propofola, bolji kvalitet anestezije i smanjenje nezeljenih dejstava. Oporavak je bio brzi u grupi koja nije dobijala midazolam, sto nije imalo klinicki znacaj. Zakljucak je da koindukcija kombinacijom midazolam-propofol ima prednost kod intervencija u ambulantnim uslovima.
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Özaltun, Betül, and Zeliha Selamoğlu. "Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects." Turkish Journal of Agriculture - Food Science and Technology 7, no. 4 (April 24, 2019): 684. http://dx.doi.org/10.24925/turjaf.v7i4.684-687.2486.

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Propofol is used in general anesthesia and sedation. İt is an lipofilic agent and metabolize to inactive form in liver then excreted in the urine. In body it is turnover changes by human serum albumin amount. >97% of propofol is bound to serum albumin. So that hypoalbunemia changes propofol effects. Free form of propopol can pass all membrans such as the blood-brain barrier and the cellular membrane of the cardiac endothelium. Propofol may cause significant myocardial depression, decrease blood pressure and cause life threatining arytmias. Changes in the ratio of free and bound forms of propofol and albumin depending on the dose and duration of administration, the effects of this ratio on cardiac profile are discussed in this study. According to the findings, it was determined that the albumin affinity of propofol decreased in all dose groups in time. Since free HSA and free propofol ratio will increase, this situation is thought to affect the cardiac profile negatively.
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Penning, Donald, Simona Cazacu, Raphael Nizar, Cunli Xiang, Hodaya Goldstein, Matan Krasner, Efrat Barbiro-Michaely, et al. "SYST-24 PROPOFOL EXERTS ANTI-TUMOR EFFECTS IN GLIOMA AND THE TUMOR MICROENVIRONMENT VIA NON-CODING RNAS AND SECRETED EXOSOMES." Neuro-Oncology Advances 5, Supplement_3 (August 1, 2023): iii32. http://dx.doi.org/10.1093/noajnl/vdad070.126.

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Abstract BACKGROUND Glioblastoma (GBM), is the most common primary brain tumor. GBM contains a small subpopulation of glioma stem cells (GSCs) that are implicated in tumor recurrence and treatment resistance and therefore represent important therapeutic targets. Recent clinical studies suggest propofol impacts subsequent tumor response to treatments and patient prognosis. The effects of propofol on patient derived GSCs alone and in combination with radiation and temozolomide, (TMZ) have not been reported. Objectives: The molecular mechanisms underlying propofol’s anti-tumor effects on GSCs and its effect on cellular communication with microglia was studied. Using GSC spheroids, differentiated glioma and tumor cells on a microfluid chip, effects of propofol alone and together with radiation and TMZ on the self-renewal and stemness of GSCs, their mesenchymal transit and the proliferation and apoptosis of differentiated glioma cells was analyzed. Using transwell plates, the effects of propofol on the cross-talk of GSCs with human microglia cells was examined. RESULTS Propofol exerted a dose-dependent inhibitory effect on the self-renewal, expression of mesenchymal markers and migration of GSCs and sensitized them to both temozolomide (TMZ) and radiation. At higher concentrations propofol induced a large degree of cell death as demonstrated using microfluid chip. Propofol increased the expression of the lncRNA BDNF-AS, which acts as a tumor suppressor in GBM and silencing of this lncRNA partially abrogated propofol’s anti-tumor effects. Propofol also inhibited the pro-tumorigenic GSC-microglia cross talk via extracellular vesicles (EVs) and delivery of BDNF-AS. CONCLUSIONS Propofol exerted anti-tumor effects on GSCs and differentiated glioma cells by inhibiting cell renewal, proliferation, and mesenchymal transition and by inducing cell death at higher concentration. Propofol also sensitized GSCs to radiation and TMZ. Propofol, which is widely used in GBM surgeries, should be further explored as a potential repurposed drug during resection and an effective adjunct to radiation and TMZ.
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Alphin, Robert S., Jeffrey R. Martens, and Donn M. Dennis. "Frequency-dependent Effects of Propofol on Atrioventricular Nodal Conduction in Guinea Pig Isolated Heart." Anesthesiology 83, no. 2 (August 1, 1995): 382–94. http://dx.doi.org/10.1097/00000542-199508000-00019.

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Background The use of propofol has been associated with episodes of bradycardias. The mechanism(s) underlying these phenomena are not well defined. Therefore we investigated (1) the chronotropic and dromotropic effects of propofol, (2) the frequency-dependent effects of propofol on the atrioventricular (AV) node, and (3) the physiologic mechanism(s) underlying propofol's effects on AV nodal conduction. Methods Guinea pig isolated, perfused hearts were instrumented for measurement of atrial rate and AV nodal conduction time in spontaneously beating hearts, or stimulus-to-His bundle (S-H) intervals in atrially paced hearts. In addition, the Wenckebach cycle length, effective refractory period and S-H interval prolongation to an abrupt increase in pacing rate were measured to further define propofol's dromotropic effects and frequency-dependent behavior. Results Propofol, in a concentration-dependent manner, (1) slowed atrial rate and AV nodal conduction time in spontaneously beating hearts, (2) prolonged the S-H interval in atrially paced hearts, and (3) prolonged Wenckebach cycle length and effective refractory period. The negative dromotropic effect of propofol was greater during atrial pacing than in spontaneously beating hearts. Furthermore, this effect was enhanced at faster pacing rates, indicating frequency-dependent behavior. Atropine significantly antagonized propofol-induced S-H interval prolongation. The results of competition binding studies also supported a M2-muscarinic receptor-mediated mechanism. Conclusions We conclude that in the isolated guinea pig heart, propofol slows atrial rate and depresses AV nodal conduction in a concentration-dependent manner. The negative dromotropic effect of propofol shows frequency dependence and is predominantly mediated by M2-muscarinic receptors. Given the marked rate dependence of propofol's AV nodal actions, this anesthetic agent may impart antidysrhythmic protection to those patients susceptible to supraventricular tachycardias.
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Nizar, Rephael, Simona Cazacu, Cunli Xiang, Matan Krasner, Efrat Barbiro-Michaely, Doron Gerber, Jonathan Schwartz, et al. "Propofol Inhibits Glioma Stem Cell Growth and Migration and Their Interaction with Microglia via BDNF-AS and Extracellular Vesicles." Cells 12, no. 15 (July 25, 2023): 1921. http://dx.doi.org/10.3390/cells12151921.

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Glioblastoma (GBM) is the most common and aggressive primary brain tumor. GBM contains a small subpopulation of glioma stem cells (GSCs) that are implicated in treatment resistance, tumor infiltration, and recurrence, and are thereby considered important therapeutic targets. Recent clinical studies have suggested that the choice of general anesthetic (GA), particularly propofol, during tumor resection, affects subsequent tumor response to treatments and patient prognosis. In this study, we investigated the molecular mechanisms underlying propofol’s anti-tumor effects on GSCs and their interaction with microglia cells. Propofol exerted a dose-dependent inhibitory effect on the self-renewal, expression of mesenchymal markers, and migration of GSCs and sensitized them to both temozolomide (TMZ) and radiation. At higher concentrations, propofol induced a large degree of cell death, as demonstrated using microfluid chip technology. Propofol increased the expression of the lncRNA BDNF-AS, which acts as a tumor suppressor in GBM, and silencing of this lncRNA partially abrogated propofol’s effects. Propofol also inhibited the pro-tumorigenic GSC-microglia crosstalk via extracellular vesicles (EVs) and delivery of BDNF-AS. In conclusion, propofol exerted anti-tumor effects on GSCs, sensitized these cells to radiation and TMZ, and inhibited their pro-tumorigenic interactions with microglia via transfer of BDNF-AS by EVs.
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Pollina, Cole, Luis Fernandez-Nava, and Cooper Phillips. "The effects of body habitus, age, and sex on adequate propofol dosing and infusion for general anesthesia." Southwest Respiratory and Critical Care Chronicles 11, no. 47 (April 25, 2023): 21–25. http://dx.doi.org/10.12746/swrccc.v11i47.1119.

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Propofol (Diprivan) is the most widely used intravenous (IV) anesthetic for the induction and maintenance of general anesthesia. Its rapid onset, fast recovery, and antiemetic properties make propofol a popular anesthetic drug over competing drugs, such as etomidate, ketamine, and halogenated gases. While there is general agreement about the physiological effects of propofol, inconsistent dosing metrics likely complicate its disputed effects on peri- and post-operative hemodynamics and cardiac function in the literature. This review provides the rationale for the recommended dosing metric of propofol and clarifies the bodily effects of dose-appropriate propofol use. This was achieved through a systematic review of propofol’s mechanism of action and observed physiological effects with respect to body habitus, age, and sex.Keywords:propofol, anesthesia, hemodynamics, induction
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Li, Weiguang, Yu Zhang, Yanru Liu, Feng Yue, Yiming Lu, Huanrong Qiu, Dawen Gao, et al. "In Vitro Kinetic Evaluation of the Free Radical Scavenging Ability of Propofol." Anesthesiology 116, no. 6 (June 1, 2012): 1258–66. http://dx.doi.org/10.1097/aln.0b013e3182567dcc.

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Background Propofol is a widely used, short-acting, and intravenously administered hypnotic agent with notable antioxidant and free radical scavenging activities. However, there are relatively few kinetic studies on the free radical scavenging ability of propofol. The goal of this study is to evaluate the kinetics of propofol scavenging 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical (ABTS(·+)). Methods The stock solution of ABTS(·+) was prepared by incubating 7 mM ABTS with 2.8 mM potassium persulfate in deionized water, and then diluted with 5 mM phosphate-buffered saline (pH 7.2) to get a working solution (36 μM ABTS(·+) and 18 μM ABTS). The reaction was monitored by measuring specific absorbance changes of ABTS and ABTS(·+) after adding 4 μM propofol (final concentration) to the working solution. The propofol-ABTS(·+) reaction products were analyzed by high-performance liquid chromatography and liquid chromatography mass spectrometry/mass spectrometry. Results Wave scanning and kinetic evaluation demonstrated that the ABTS(·+) scavenging process of propofol is relatively fast. The ABTS(·+) consumption rate by propofol is greater than the rate of ABTS formation. The degradation products of reaction between propofol and ABTS(·+) were mainly ABTS-propofol, a part of the ABTS molecule, and a combination of propofol with a part of the ABTS molecule. Conclusions Propofol scavenges ABTS(·+) with a fast and stable kinetic feature in vitro, which is useful and important for understanding propofol's antioxidant properties. The kinetic process of the free radical scavenging activity of propofol may also play a role in dynamic protection in the body.
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Kraut, Richard A. "Propofol." Oral and Maxillofacial Surgery Clinics of North America 4, no. 4 (November 1992): 825–30. http://dx.doi.org/10.1016/s1042-3699(20)30647-6.

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&NA;. "Propofol." Reactions Weekly &NA;, no. 1376 (November 2011): 24–25. http://dx.doi.org/10.2165/00128415-201113760-00078.

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&NA;. "Propofol." Reactions Weekly &NA;, no. 1376 (November 2011): 25. http://dx.doi.org/10.2165/00128415-201113760-00083.

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Dissertations / Theses on the topic "Propofol"

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Sudmantaitė, Aistė. "Ketamino, propofolio ir ketamino/propofolio derinio farmakologinio poveikio įvertinimas ir palyginimas eksperimentiniame izoliuotų aortos ir trachėjos žiedų modelyje in vitro." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140630_135759-79575.

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Tyrimo darbo tikslas - įvertinti ir palyginti propofolio, ketamino ir jų derinio farmakologinį poveikį eksperimentiniame izoliuotų aortos ir trachėjos žiedų modelyje in vitro. Bandymui atlikti naudojama vienos kameros organų vonelė. Rezultatai fiksuojami programine įranga LabChart 7. Pasirinkti laboratoriniai gyvūnai – 6 Jūrų kiaulyčių patinėliai. Vaistų poveikis vertinimas izoliuotiems aortos ir trahėjos segmentams. Segmentų kontrakcija sukeliama Krebso tirpalu, kuriame yra ištirpintas KCl (80 mmol/l). Pasiekus maksimalų susitraukimą, kumuliuojančiomis koncentracijomis (10-5 M, 10-4 M, 10-3 M), į vonelę pilamas ketamino, propofolio ir jų derinio tirpalas ir kiekvienu atveju fiksuojamas jėgos pokytis. Ketaminas aortos žiedą atpalaiduoja esant didelėms (10-3 M) ir vidutinėms (10-4 M) koncentracijoms, o propofolis ir ketamino/propofolio derinys tik esant didelėms koncentracijoms (p<0,05). Ketaminas, propofolis ir jų derinys atpalaiduoja trachėjos žiedą esant vidutinėms ir didelėms koncentracijoms (p<0,05). Ketamino vidutinė koncentracija turi didesnį poveikį aortos, o vidutinė ir didelė koncentracija – trachėjos žiedo atsipalaidavimui nei propofolis (p<0,05). Ketamino/propofolio derinys santykiu 1:1 esant 10-4 M koncentracijai mažiau veikia aortos atsipalaidavimą nei ketaminas (p<0,05), o 10-4 M ir 10-3 M derinio koncentracijos mažiau veikia trachėjos atsipalaidavimą nei vartojant ketaminą ir propofolį ne derinyje (p<0,05). Didėjant vaistų koncentracijai, didėja jų dilatacinis... [toliau žr. visą tekstą]
The aim of the study was to investigate and compare propofol, ketamine and ketamine/propofol combination pharmacological effects of isolated aortic and tracheal rings in vitro. Single-chamber organ bath was used for the experiment. The results were recorded by LabChart software. Selected laboratory animals – 6 guinea pig males. The influence of medicine over isolated aorta and trachea rings was evaluated. Pre-contraction was induced by Krebs solution containing dissolved KCl (80 mmol/l). After reaching the maximum contraction of the preparation, propofol, ketamine and ketamine/propofol mixture solution was separately added to the bath in a cumulative concentrations (10-5 M, 10-4 M, 10-3 M) and in each case the force change was recorded. Ketamine relaxed aortic rings at medium and large concentrations, while propofol and ketamine/propofol mixtures only in large concentrations (p<0,05). Medium concentration of ketamine showed a greater effect on aortic rings than propofol and medium and large concentrations showed a greater effect on trachea ring than equal concentration of propofol (p<0,05). An average concentration of a 1:1 ratio of ketamine/propofol mixture, had a lower impact on aortic ring relaxation than an equal concentration of ketamine (p <0.05). A high concentration of 1:1 ratio of ketamine/propofol had a lower impact on the trachea ring relaxation than equal concentration of ketamine and propofol used separately (p <0.05). In conclusion, contractions of aorta and... [to full text]
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Barbagallo, Alessia Anna. "Colecistectomia Videolaparoscopica: confronto Remifentanil/Propofol vs Fentanil/Propofol nel mantenimento anestesiologico." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/321.

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La chirurgia laparoscopica e' anche detta chirurgia miniinvasiva, o chirurgia dei cerottini o chirurgia del buco della serratura. Il dolore postoperatorio e' minimo, il paziente puo' alzarsi e bere il giorno dell' intervento. Anche dal punto di vista estetico il risultato e' ottimo, per l' assenza di cicatrici. L'obiettivo della ricerca e' stato di valutare durante l' intervento di colecistectomia laparoscopica i differenti effetti emodinamici che si ottengono effettuando l'anestesia con l'associazione REMIFENTANIL/PROPOFOL in comparazione a quella FENTANIL/PROPOFOL. Il risultato ottenuto e' che nella chirurgia videolaparoscopica per intervento di colecistectomia, l' anestesia effettuata con remifentanil ha offerto, nella popolazione studiata e rispetto all' altro oppioide fentanyl, una migliore stabilita' emodinamica in termini di minore incidenza di episodi di ipertensione e tachicardia.
The laparoscopic surgery is also called miniinvasive surgery or "band aid surgery" or "key hole surgery". The positive aspects are enormous because the postoperative pain is minimum. The patient can get up and drink the same day of the operation. The result is very good also from the aesthetich point of view for the absent of scar. The objective of this research was to evaluate, during cholecystectomy operations by laparoscopic technique, the hemodynamic effects abtained with anaesthesia made with the association of remifentanil/propofol in comparison with fentanil/propofol. In the laparoscopic surgery for cholecystectomy anaesthesia made with remifentanil has given the result of a better hemodinamics stability in the studied population in comparison with the other opioid fentanil, in terms of minor incidence of hypertention and tachycardia events.
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Fernandez, Thierry. "Electroconvulsivotherapie et Propofol : revue de la littérature et résultats d'une étude clinique." Bordeaux 2, 1995. http://www.theses.fr/1995BOR23009.

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Metzger, Hélène. "Un nouvel agent anesthésique : Le propofol (Diprivan)." Strasbourg 1, 1988. http://www.theses.fr/1988STR15002.

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Bester, Lynette. "Pharmacokinetics of propofol in cats." Diss., University of Pretoria, 2009. http://hdl.handle.net/2263/22954.

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Since the introduction of the lipid emulsion formulation in 1986, propofol has become established for induction as well as for maintenance of anaesthesia in veterinary practice1 including cats2;3-8. Propofol is rapidly metabolized by hepatic glucuronidation in most species and it has also been shown to undergo extrahepatic metabolism9-13, so that total body clearance may exceed liver blood flow in certain species. Because of their highly carniverous diet, cats are little exposed to antiherbivory compounds so that they have become deficient in UGP-glucuronosyltransferase (UGT)14. Consequently, a number of drugs are eliminated slowly15;16, often giving rise to prolonged half-lives of the parent drugs. Cats are therefore sensitive to the adverse effects of many drugs and toxins that are normally glucuronidated before elimination. It is therefore likely that the disposition of propofol may differ markedly from that of humans and other animal species17. Adam et al18 reported that for the cremophor propofol formulation in cats, volumes of distribution were smaller and elimination halflives were longer than those of pigs, rats and rabbits. In addition, pulmonary uptake has been demonstrated to occur in cats,19 however propofol’s pharmacokinetics have not been studied formally. The purpose of this study was to determine the pharmacokinetic behaviour of propofol after single intravenous injections. In comparison with man, the apparent central volume of distribution in domestic cats is small (0.56L.kg-1 body weight vs. 0.228L.kg-1) for the human pharmacokinetic parameter set of Marsh et al20 and the clearance (0.0086 L.kg-1.min-1 vs. 0.027 L.kg- 1.min-1) is approximately 2½ times slower in cats when compared with humans. Slow clearance should not influence recovery from anaesthesia following standard induction doses, because the early decreases in blood concentrations are predominantly due to redistribution of drug to various tissues (similar to the disposition of thiopentone which exhibits a slow total body clearance21. However it is possible that drug may accumulate within the body after prolonged infusions, resulting in delayed recovery times. This phenomenon is best described by calculating “context-sensitive” decrement-times by computer simulation22-24. Computer software♣ were used to calculate the 20%, 50% and 80% context-sensitive decrement times for the cat pharmacokinetic model. For comparative purposes, similar calculations were performed for an adult human male (weight 70 kg) using the pharmacokinetic parameter-set of Marsh et al20. Assuming that recovery from anaesthesia occurs after a 50% decrease in blood concentrations has taken place, it is apparent from the 50% context-senstive decrement-time graph that for infusions lasting up to 20 minutes (during which concentrations are kept constant), recovery can be expected to be rapid and predictable. However if infusions are administered for longer than 20 minutes, the recovery times of the “average” cat increase rapidly, reaching a plateau of 36 minutes, while recovery times of the human remain short, albeit increasing slowly. Awakening times become dramatically prolonged and unpredictable in both cats and humans if propofol concentrations are required to decrease by 80% for recovery to occur. Under these circumstances the 80% decrement time after a two-hour infusion is approximately two hours in cats and 45 minutes in humans. On the other hand, if dosing is conservative, so that blood concentrations need to decrease by only 20% for awakening to occur, then recovery times are short and predictable, being only a few minutes, regardless of the duration of the preceding infusion. These findings are in accordance with those of Pascoe et al25 who reported that cats took longer to recover after a short (30 min) infusion than after a long (150 min) infusion. In their crossover study, the propofol infusion rates were adjusted so that the cats were maintained at a light level of anaesthesia at which they responded sluggishly to pedal stimulation. It is therefore likely that propofol concentrations were kept steady and were similar during the 30-minute as well as during the 150-minute infusions. Delayed recovery has also been reported when propofol was administered to cats on consecutive days26. Conclusions and clinical relevance: We recommend that propofol infusions be administered to cats only for fairly short procedures and that for prolonged surgery, maintenance of anaesthesia should be accomplished using other drugs. In order to decrease the propofol dose, premedication and analgesic supplements should be co-administered to provide “balanced” anaesthesia. ♣ TIVA Trainer version 8, author Frank Engbers, Leiden University Medical Centre Copyright
Dissertation (MMedVet)--University of Pretoria, 2009.
Companion Animal Clinical Studies
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Bester, Lynette. "Pharmacokinetics of propofol in cats." Pretoria : [s.n.], 2021. http://upetd.up.ac.za/thesis/available/etd-03032010-184513/.

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Biteli, Eliselle Gouveia de Faria. "Efeitos da infusão contínua de tiopental ou propofol em coelhos mantidos em respiração espontânea /." Jaboticabal, 2014. http://hdl.handle.net/11449/122120.

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Orientador: Newton Nunes
Coorientador: Patrícia Cristina Ferro Lopes
Banca: Paulo Sérgio Patto dos Santos
Banca: Roberta Carareto
Resumo: Avaliaram-se, comparativamente, os efeitos do tiopental e do propofol sobre os parâmetros cardiovasculares, respiratórios, hemogasométricos, nível glicêmico, cinética celular e período de recuperação. Para tanto, utilizaram-se 20 coelhos da raça Nova Zelândia Branco, adultos, machos ou fêmeas, com peso médio de 3,67±0,43 Kg. Após seleção aleatória, estes foram distribuídos em dois grupos de 10 animais, denominados grupo propofol (GP) e grupo tiopental (GT). Para o GP, foi induzida a anestesia geral pela administração intravenosa (IV) de propofol (10 mg/Kg) e em seguida, iniciou-se a infusão contínua na dose inicial 1 mg/Kg/min, a qual, havendo necessidade, foi reajustada de modo a que o índice biespectral estivesse situado entre 65 e 75. Para o GT empregou-se a mesma metodologia, substituindo-se o propofol pelo tiopental. As observações das variáveis de interesse em ambos os grupos, tiveram início 20 minutos após a indução anestésica (M0) e novas mensurações foram realizadas em intervalos de 15 minutos, por um período de 60 minutos. A avaliação da recuperação teve início 30 minutos (MR30) após o término da infusão dos fármacos e novas avaliações foram realizadas em intervalos de 60 minutos. Os dados foram submetidos à análise de variância de duas vias (Two-way ANOVA) e uma via (One-way ANOVA), seguidas pelo teste de Bonferroni (p<0,05). Para a análise da recuperação, os escores foram analisados e os grupos comparados pelo teste não paramétrico de Wilcoxon de 2 amostras independentes (p<0,05). No GP, a pressão parcial de oxigênio (PaO2) o dióxido de carbono (PaCO2) e a saturação da oxihemoglobina (SaO2) no sangue arterial aumentaram a partir do M30 e no M60, respectivamente. O volume corrente (VT), no M60, e o índice respiratório (IR), no M0, foram menores no GP, enquanto o conteúdo arterial de oxigênio (CaO2), no M0, foi maior no GP que no GT. A pressão de oxigênio alveolar ...
Abstract: The effects of thiopental and propofol were comparatively evaluated about its influence on cardiovascular and respiratory parameters, blood gas, blood glucose levels, cell kinetics and recovery period in 20 rabbits of New Zealand White, adults, male and female, with weight between 3,67±0,43 Kg. After a random selection, they were shared into two groups of 10 animals, called propofol group (GP) and thiopental group (GT). For GP, general anesthesia was induced by intravenous (IV) administration of propofol (10 mg/Kg) and then began continuous infusion at an initial dose 1 mg/Kg/min, and then was adjusted as necessary to the bispectral index values vary between 65 and 75. The same method was employed for GT, using thiopental instead propofol, at the dose of 10 mg/Kg for induction followed the initial dose of 1 mg/Kg/min. Data collection of the variables of interest in both groups began 20 minutes after induction of anesthesia (M0) and new measurements were made at 15 minutes intervals for a period of 60 minutes. The assessment of recovery began 30 minutes (MR30) after the infusion of agents and new evaluations were made at intervals of 60 minutes. Data were analysed using to analysis of variance, two-way (two-way ANOVA) and route (One-way ANOVA) followed by Bonferroni test (p<0,05). For recovery assessment, the scores were analyzed and the groups were compared by non parametric Wilcoxon test for 2 independent samples (p<0,05). In GP, the partial pressure of oxygen (PaO2), carbon dioxide (PaCO2) and oxyhemoglobin saturation (SaO2) in arterial blood increased from M30 and M60, respectively. The tidal volume (VT) in M60, and respiratory index (IR) in M0, were lower in the GP, while the arterial oxygen content (CaO2) at M0 was greater in GP than in GT. The alveolar oxygen tension (PAO2), alveolar-arterial oxygen difference (P(A-a)O2), IR, arterial-alveolar ratio (PaO2/PAO2) and ratio of partial pressure of arterial oxygen to fraction of ...
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Yılmaz, Funda Ceylan Berit Gökçe. "Desfluranın antioksidan etkinliğinin propofol ile karşılaştırılması /." Isparta: SDÜ Tıp Fakültesi, 2006. http://tez.sdu.edu.tr/Tezler/TT00263.pdf.

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Raux, Olivier. "Utilisation de la circulation extracorporelle comme modèle d'étude hémodynamique : application au propofol." Montpellier 1, 1993. http://www.theses.fr/1993MON11095.

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El, Hachem Tanios. "Le propofol comme agent de sédation en réanimation." Montpellier 1, 1989. http://www.theses.fr/1989MON11322.

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Books on the topic "Propofol"

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R, Bevan David, and MES Medical Education Services (Canada), eds. New horizons in anaesthesia: Focus on propofol : proceedings of a symposium held in Ottawa, Canada, June 9, 1989. Oxford: MEDICINE Publishing Foundation, 1989.

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Killian, Aaron. Potential advantages associated with propofol anesthesia in outpatient surgical procedures. [Ottawa: Ottawa General Hospital[, 1991.

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Bonn, Universität, ed. Einfluss von Propofol auf Parameter der zellulären Immunität. [s.l.]: [s.n.], 1993.

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Schüttler, Jürgen. Pharmakokinetik und -dynamik des intravenösen Anaesthetikums Propofol (Disoprivan®). Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-46706-6.

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McAdam, Laura Catherine. Propofol and benzodiazepine modulation of GABA[subscript]AR function. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1999.

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Magathan, Jose G. Propofol: A new intravenous anaesthetic agent : a review of the literature. [Toronto: Faculty of Dentistry, University of Toronto], 1992.

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D'Aguiam, George. Propofol as the sole intravenous agent for conscious sedation in dentistry. [Toronto: Faculty of Dentistry, University of Toronto], 1994.

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Ahmad, Iftikhar. Pro and anticonvulsant activity of opioid analgesics and their interaction with propofol. Manchester: University of Manchester, 1994.

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Lang, Tatjana. Narkose bei Schildkröten unter besonderer Berücksichtigung von Propofol und Isofluran: Eine klinische Studie. München: Hieronymus, 2002.

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Scheel, Andrea. Aufbau, Evaluierung und Anwendung sensitiver und spezifischer Methoden zur Bestimmung von Propofol und Propofolchinon in biologischen Flüssigkeiten mittels Hochleistungs-Flüssigkeitschromatographie. Lübeck: Zentrale Hochschulbibliothek Lübeck, 2011.

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Book chapters on the topic "Propofol"

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Lefebvre, Cedric W., Jay P. Babich, James H. Grendell, James H. Grendell, John E. Heffner, Ronan Thibault, Claude Pichard, et al. "Propofol." In Encyclopedia of Intensive Care Medicine, 1854–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_761.

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Couloures, Kevin G., and Michael Hooper. "Propofol." In Sedation and Analgesia for the Pediatric Intensivist, 433–41. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52555-2_31.

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McAllister-Williams, R. Hamish, Daniel Bertrand, Hans Rollema, Raymond S. Hurst, Linda P. Spear, Tim C. Kirkham, Thomas Steckler, et al. "Propofol." In Encyclopedia of Psychopharmacology, 1074. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_7006.

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Petroianu, Georg, and Peter Michael Osswald. "Propofol." In Anästhesie in Frage und Antwort, 167–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-662-05715-5_57.

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Doenicke, A., B. Ulsamer, O. A. Müller, H. Suttmann, R. Raps, and W. Wuttke. "Propofol." In Aktueller Stand der klinischen Anaesthesie, 87–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71229-6_15.

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Aboian, Mariam, Jason M. Johnson, and Daniel Thomas Ginat. "Propofol." In Neuroimaging Pharmacopoeia, 347–49. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-12715-6_50.

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Aboian, Mariam, Jason M. Johnson, and Daniel Thomas Ginat. "Propofol." In Neuroimaging Pharmacopoeia, 281–83. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08774-5_40.

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Frost, Elizabeth A. M., and Ethan O. Bryson. "Propofol Abuse." In Perioperative Addiction, 179–88. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0170-4_10.

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Doenicke, A. "Etomidat — Propofol." In Konzepte zur Sicherheit in der Anästhesie, 57–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-77781-3_7.

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Grandhi, Ravi K., and Alaa Abd-Elsayed. "Propofol Infusion Therapy." In Infusion Therapy, 27–38. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17478-1_3.

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Conference papers on the topic "Propofol"

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Rewa, Oleksa G., and John Muscedere. "Propofol Infusion Syndrome (PRIS)." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a3082.

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Albuquerque, Juliana Maria de Oliveira, and Susan Carolyne Da Silva Freire. "HIPOPROTEINEMIA POR OVERDOSE DE PROPOFOL." In I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1817.

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Introdução: o propofol é um anestésico da classe dos alquilfenóis, podendo ser usado como sedativo para anestesia geral ou medicação pré-anestésica. O medicamento em questão, usado em excesso leva a hipoproteinemia, que nada mais é do que a redução das proteínas do sangue. Esta revisão bibliográfica foi realizada com base no relato de caso da anestesia intravenosa com propofol em ovinos. A medicação pré anestésica foi composta por cetamina 4,5 mg kg, midazolam 0,1 mg kg e tramadol 2 mg kg, e a indução com propofol 3,5 mg Kg junto com cetamina 1 mg Kg, a manutenção anestésica foi feita com propofol 0,28 mg Kg e cetamina 0,06 mg kg, durante 60 minutos. O foco vai ser dado para as amostras hemogasométricas, que foram retiradas no pré cirúrgico e a cada 30 minutos. Objetivo: Expor o risco de usar propofol por tempo prolongado, mesmo com a dosagem adequada. Material e métodos: os materiais usados foram estudos de casos que relataram hipoproteinemia após utilizar propofol, com foco no relato de caso de ovinos, sempre comparando e relacionando-os. Resultados: Observou-se nos exames que a hipoproteinemia ocorreu após 60 minutos. A administração em tempos prolongados por propofol leva o animal a ter uma overdose, resultando em hipoproteinemia. Conclusão: O trabalho baseado nesta revisão só mediu em 3 tempo a gasometria, o que nos dá uma margem muito grande de erro, pois antes mesmo dos 60 minutos o animal já pode estar saturado por propofol, seria interessante fazer um analise a cada 10 minutos para ter maior precisão até onde podemos fazer a administração sem causar sérios danos ao animal.
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Hajare, Ankita, and Irrfan Waris. "Comparison of Midazolam with Propofol & Propofol alone in Minor Oral & Maxillofacial Surgical Procedures." In ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter. Indian Society of Anaesthesiologists (ISA), 2017. http://dx.doi.org/10.18311/isacon-karnataka/2017/fp049.

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Vadigeri, Prashanth, Vidya Patil, and Shivanand. "Comparison of Dexmeditomidine-Propofol vs Fentanyl-Propofol for Laryngeal Mask Airway Insertion in Elective Surgeries." In ISACON KARNATAKA 2017 33rd Annual Conference of Indian Society of Anaesthesiologists (ISA), Karnataka State Chapter. Indian Society of Anaesthesiologists (ISA), 2017. http://dx.doi.org/10.18311/isacon-karnataka/2017/fp089.

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Oliva Ramos, Alicia, Luis Puente Maestu, Paola Benedetti, Alicia Cerezo Lajas, Laura Ramirez García, and Jose Javier García Lopez. "Propofol sedation in bronchoscopy by pulmonologists." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa3798.

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Singh, Harpreet, B. Gupta, and Meenaxi Sharma. "15. Comparison of propofol anesthesia to dexmedetomidine + propofol for intraoperative management and emergence in craniotomy surgery." In 15th Annual Conference of the Indian Society of Neuroanaesthesiology and Critical Care. Thieme Medical and Scientific Publishers Private Ltd., 2014. http://dx.doi.org/10.1055/s-0038-1646094.

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Sedhai, Y. R., R. Baniya, and S. Basnyat. "A Case of Propofol Induced Green Urine." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7072.

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Syafiie, S., M. Ait Rami, and F. Tadeo. "Positive infusion of propofol drug during induction." In EM). IEEE, 2010. http://dx.doi.org/10.1109/ieem.2010.5674305.

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Pawlowski, Andrzej, Michele Schiavo, Nicola Latronico, Massimiliano Paltenghi, and Antonio Visioli. "MPC for Propofol Anesthesia: the Noise Issue." In 2022 IEEE Conference on Control Technology and Applications (CCTA). IEEE, 2022. http://dx.doi.org/10.1109/ccta49430.2022.9966102.

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Sartori, V., P. M. Schumacher, T. Bouillon, M. Luginbuehl, and M. Morari. "On-line estimation of propofol pharmacodynamic parameters." In 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616345.

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Reports on the topic "Propofol"

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Burnett, Jaclyn, Montana Betts, Christhian de Ochoa, Maciej Chec, and Dwayne Accardo. Dexmedetomidine vs. Propofol in Postoperative Delirium Prevention. University of Tennessee Health Science Center, May 2022. http://dx.doi.org/10.21007/con.dnp.2022.0038.

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Bannister, Isabel, Abigail Banko, Reid Blaylock, Abigail Kurtz, Tracy McClinton, and Caitlin Bradford. Decreasing Postop Delirium with Dexmedetomidine vs Propofol. University of Tennessee Health Science Center, April 2023. http://dx.doi.org/10.21007/con.dnp.2023.0066.

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Hughes, Lauren M., Michael G. Irwin, and Claire C. Nestor. Adjuvant medications for use with propofol-based total intravenous anaesthesia. World Federation of Societies of Anaesthesiologists, August 2024. http://dx.doi.org/10.28923/atotw.529.

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Knowledge of the pharmacological differences between opioid and non-opioid TIVA adjuncts is essential for providing safe and effective TIVA. Whilst opioids play a large role in providing the analgesic component of TIVA, non-opioid adjuncts should also be considered. Selected concentrations of TCI infusions should be individualised to the patient, extent of surgery, and other drugs administered. It is essential to calibrate the TCI to the patient’s response at all times. These basic principles reiterate the recommendations from the international guidelines for TIVA administration ​(31)​, and remain true regardless of the different agents used.
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Tang, Yaxing, Lele Tang, Yuting Yao, He Huang, and Bing Chen. Effects of propofol-based total intravenous anesthesia versus inhalation anesthesia on long-term survival in patients undergoing cancer surgery: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0025.

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Review question / Objective: To compare the effects of propofol-based total intravenous anesthesia with inhalation anesthesia on long-term survival of cancer surgery. (1) Patients: all patients undergoing cancer surgery with intravenous or inhalation anesthesia. (2) Intervention: propofol-based total intravenous anesthesia. (3) Comparator: inhalation anesthesia. (4) Outcomes: overall survival, recurrence- free or disease-free survival. (5) Study design: randomized-controlled trials and observational studies (prospective or retrospective). Information sources: We will systematically search the following electronic databases (PubMed, Medline, Embase, and the Cochrane Library) from inception to July 2022 for eligible studies. Any potentially relevant studies will be manually searched based on the references of the identified studies.
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Killpack, John R. Comparison Of The Direct Costs, Length Of Recovery, And Incidence Of Post Operative Anti Emetic Use After Anesthesia Induction With Propofol Or A 1:1 Mixture Of Thiopental And Propofol. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ad1012143.

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Ding, Huaze, Yiling Dong, Kaiyue Zhang, Jiayu Bai, and Chenpan Xu. Comparison of dexmedetomidine versus propofol in mechanically ventilated patients with sepsis: A meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0103.

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Review question / Objective: The aim of the present study was to evaluate the effects of dexmedetomidine compared with propofol in mechanically ventilated patients with sepsis. Condition being studied: Sepsis, which is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, contributes the highest mortality to intensive care units (ICU) worldwide . Because of the high incidence of respiratory failure in sepsis care, mechanical ventilation is always adopted to give life support and minimize lung injury . And sedation is a necessary component of sepsis care who suffers from mechanical ventilation. The Society of Critical Care Medicine suggested using either propofol or dexmedetomidine for sedation in mechanically ventilated adults. However, it remained unknown whether patients with sepsis requiring mechanical ventilation will benefit from sedation with dexmedetomidine.
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Guo, Hao, and Jiao Huang. Comparison of remimazolam and propofol on postoperative quality of recovery: a meta-analysis of randomised controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2024. http://dx.doi.org/10.37766/inplasy2024.6.0044.

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Huang, Ze-qing. Does propofol ameliorate occurrence of postoperative cognitive dysfunction after general anaesthesia? A protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0103.

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Liu, Weihua, Wenli Yu, Hongli Yu, and Mingwei Sheng. Comparison of clinical effects and safety between dexmedetomidine and propofol among patients who underwent gastrointestinal endoscopy: A meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2021. http://dx.doi.org/10.37766/inplasy2021.6.0058.

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Li, Hai-ying. Anesthetic efficacy of propofol combined butorphanol in laparoscopic surgery for ectopic pregnancy: a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0044.

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