Relevant bibliographies by topics / Proliferation index

Academic literature on the topic 'Proliferation index'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Proliferation index"

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Rajeshwari B, Rajeshwari B., Salapathi Shanmugam, Sadiya Niamath, Mitra Ghosh, and Siddhartha Ghosh. "Hormone Receptor Status and KI67 Proliferation Index in Meningiomas." Annals of Pathology and Laboratory Medicine 7, no. 2 (March 7, 2020): A76–82. http://dx.doi.org/10.21276/apalm.2641.

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Alexandrakis, Michael G., Freda H. Passam, Despina S. Kyriakou, Konstantina Dambaki, Maria Niniraki, and Efstathios Stathopoulos. "Ki-67 Proliferation Index." American Journal of Clinical Oncology 27, no. 1 (February 2004): 8–13. http://dx.doi.org/10.1097/01.coc.0000045810.91816.41.

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Tomaszewska, Romana, Krzysztof Okoń, Krystyna Nowak, and Jerzy Stachura. "Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions." Analytical Cellular Pathology 19, no. 3-4 (1999): 175–85. http://dx.doi.org/10.1155/1999/783401.

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The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index) in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia) and high‐grade proliferation (atypical papillary hyperplasia and carcinomain situ). A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value.
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Petrov, S. V., R. N. Kulagin, D. E. Tsyplakov, O. V. Nefedov, V. V. Saveliev, A. R. Utkuzov, and N. T. Raikhlin. "Markers of tumor cell proliferation in cancerous tumors of the larynx." Kazan medical journal 81, no. 4 (February 2, 2022): 265–68. http://dx.doi.org/10.17816/kazmj99817.

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The cell proliferative process in the larynx cancer is studied. Contrary to the classical mitotic index the Ki-67 and PCNA indices are reliable and reproducible on the clinical material by the proliferative cell activity indices of the larynx tumors. There is a reverse connection between the proliferation index in cells of the squamous larynx cancer and the tumor differentiation. The direct correlation of the cell proliferation index of the squamous laxynx cancer with the disease stage is revealed. The preoperative radiation therapy significantly decreases the cell proliferation rates of the squamous larynx cancer.
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Green, S. E., P. Chapman, J. Burn, A. D. Burt, M. Bennett, D. R. Appleton, J. S. Varma, and J. C. Mathers. "Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer." Gut 43, no. 1 (July 1, 1998): 85–92. http://dx.doi.org/10.1136/gut.43.1.85.

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Background—Despite the recent discovery of four genes responsible for up to 90% of all cases of hereditary non-polyposis colorectal cancer (HNPCC), there will still be families in whom predictive testing is not possible. A phenotypic biomarker would therefore be useful. An upwards shift of the proliferative compartment in colonic crypts is reported to be one of the earliest changes in premalignant mucosa.Aims—To assess the role of crypt cell proliferation as a phenotypic biomarker in HNPCC.Patients—Thirty five patients at 50% risk of carrying the HNPCC gene (21 of whom subsequently underwent predictive testing and hence gene carrier status was known) and 18 controls.Methods—Crypt cell proliferation was measured at five sites in the colon using two different techniques. Labelling index was determined using the monoclonal antibody MIB1 and whole crypt mitotic index was measured using the microdissection and crypt squash technique. The distribution of proliferating cells within the crypts was also assessed.Results—There were no significant differences in the total labelling index or mean number of mitoses per crypt, nor in the distribution of proliferating cells within the crypt, between the study and control groups at any site. When the 21 patients in whom gene carrier status was known were analysed separately there were no significant differences in the measured indices of proliferation between the HNPCC gene carriers and non-gene carriers.Conclusion—Crypt cell proliferation is not a discriminative marker of gene carriage in HNPCC.
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Phillips, Brenda S., Philip H. Kass, Diane K. Naydan, Michelle D. Winthrop, Stephen M. Griffey, and Bruce R. Madewell. "Apoptotic and Proliferation Indexes in Canine Lymphoma." Journal of Veterinary Diagnostic Investigation 12, no. 2 (March 2000): 111–17. http://dx.doi.org/10.1177/104063870001200202.

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Proliferative and apoptotic fractions of tumors were evaluated in 41 dogs with lymphoma for prediction of response to chemotherapy. All dogs had advanced clinical stage tumors, were untreated prior to study, and received identical induction-remission chemotherapy. Tumor cell proliferation was determined in all pretreatment biopsy specimens and in 18 specimens collected at the time of clinical relapse from remission. Quantitative measures included mitotic index and immunoreactivities for proliferating cell nuclear antigen (PCNA) and Ki-67. Apoptotic index was evaluated from 40 dogs pretreatment and from 16 dogs at the time of first relapse. Pretreatment tumor values for Ki-67, PCNA, and apoptosis were compared with posttreatment values. The median first relapse-free interval (RFI) and overall survival (OS) time were 174 days and 445 days, respectively. Of the proliferation markers, only the results of the Ki-67 analysis were predictive for duration of the first RFI but not OS. Pretreatment apoptotic index was also predictive of the duration of first RFI but not OS. No significant predictive value for comparison of the pretreatment and postrelapse values was demonstrated. Ki-67 labeling index and apoptotic indexes were combined to form both a proliferation/apoptotic ratio (PAR) and a sum, or turnover index. Only the PAR was predictive for duration of first RFI on multivariate analysis. Other variables that were evaluated for their influence on treatment outcome included patient age, weight, gender, clinical stage, clinical substage, and tumor immunophenotype. Of these variables, only immunophenotype was found to be of value for predicting duration of first RFI and OS.
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Chirieac, Lucian R. "Tumor cell proliferation, proliferative index and mitotic count in lung cancer." Translational Lung Cancer Research 5, no. 5 (October 2016): 554–56. http://dx.doi.org/10.21037/tlcr.2016.10.10.

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Kabraji, Sheheryar Kairas, Giorgio Gaglia, Danae Argyropoulou, Yang Dai, Shu Wang, Johann Bergholz, Shannon Coy, et al. "Temporal and spatial topography of cell proliferation in cancer." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): 3122. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3122.

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3122 Background: Tumors are complex ecosystems where exogenous and endogenous cues are integrated to either stimulate or inhibit cancer cell proliferation. However, the nature of these complex cell cycle states, their spatial organization, response to perturbation, and implications for clinical outcomes, are poorly characterized in tumor tissues. Methods: We used multiplexed tissue imaging to develop a robust classifier of proliferation, the multivariate proliferation index (MPI), using 513 unique tumors across five cancer types. Next, we used dimensionality reduction analysis to assess how the patterns of cell cycle protein expression in tumors were altered in response to perturbation. Results: The MPI outperforms single markers, like Ki67, when classifying proliferative index across diverse tumor types and reveals the proliferative architecture of tumors in situ. We find that proliferative and non-proliferative cancer cells are organized across microscopic (cell-to-cell) and macroscopic (tissue-level) scales. Both domains are reshaped by therapy, and local clusters of proliferative and non-proliferative tumor cells preferentially neighbor distinct tumor-infiltrating immune cells. We further phenotyped non-proliferating cancer cells using markers of quiescent cancer cells, cancer stem cells, and dormant cancer cells. We found that these types of non-proliferating cancer cells can occupy distinct regions within the same primary tumor. In high-dimensional marker space, populations of proliferative cancer cells express canonical patterns of cell cycle protein markers, a property we refer to as “cell cycle coherence”. Untreated tumors exist in a continuum of coherence states, ranging from optimal coherence, akin to freely cycling cells in culture, to reduced coherence characterized by either cell cycle polarization or non-canonical marker expression. Coherence can be stereotypically altered by induction and abrogation of mitogen signaling in a HER2-driven model of breast cancer. Cell cycle coherence is modulated by neoadjuvant therapy in patients with localized breast cancer, and coherence is associated with disease-free survival after adjuvant therapy in patients with colorectal cancer, mesothelioma and glioblastoma. Conclusions: The MPI robustly defines proliferating and non-proliferating cells in tissues, with immediate implications for clinical practice and research. The coherence metrics capture the diversity of post-treatment cell cycle states directly in clinical samples, a fundamental step in advancing precision medicine. More broadly, replacing binary metrics with multivariate traits provides a quantitative framework to study temporal processes from fixed static images and to investigate the rich spatial biology of human cancers.
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Molochkova, Yu V., A. N. Khlebnikova, V. A. Molochkov, L. E. Gurevich, and A. V. Molochkov. "Comparative study of Ki67 protein expression in oral lichen planus and leukoplakia." Vestnik dermatologii i venerologii 94, no. 4 (December 7, 2018): 15–20. http://dx.doi.org/10.25208/0042-4609-2018-94-4-15-20.

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Oral lichen planus (OLP) is included in the category of potentially malignant diseases. Benign processes are differentiated from malignant ones by the nature of cell proliferative activity. The aim of the present study was the comparative study of proliferative activity in OLP and leuk oplakia cells, as well as the cells of oral squamous cell carcinoma.Materials and methods. Biopsy specimens from 16 patients with OPL, 13 with leukoplakia, and 7 with oral squamous cell carcinoma were investigated. Immunohistochemical studies were performed using Ki67 monoclonal antibodies.Results. The average Ki67 index in OPL cells was 9.3 ± 2.3 %. Proliferating cells were located exclusively in the basal epidermis layer. In leukoplakia cells, the average Ki67 index was 20.5 ± 6.1 %; the proliferating cells were located in the basal layer and lower parts of the spinous (suprabasal) layer of the epidermis. In squamous cell carcinoma, the average Ki67 index was 57.4 ± 2.04 %. Proliferating cells were located diffusely over all cell complexes from the lower to the highest layers of the epidermis. Differences in the proliferation level were significant for the leukoplakia/OPL pair (p = 0.003) and squamous cell carcinoma/OPL pair (p < 0.001), while for squamous cell carcinoma/leukoplakia pair the difference was not significant (p = 0.211).Conclusion. The differences in the proliferation level and in the nature of the proliferating cell distributionin through the epidermis can be applied in the differential diagnosis of OPL and leuk oplakia.
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Weerasooriya, Viraine, Michael J. Rennie, Shri Anant, David H. Alpers, Bruce W. Patterson, and Samuel Klein. "Dietary fiber decreases colonic epithelial cell proliferation and protein synthetic rates in human subjects." American Journal of Physiology-Endocrinology and Metabolism 290, no. 6 (June 2006): E1104—E1108. http://dx.doi.org/10.1152/ajpendo.00557.2005.

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Although it has been proposed that high fiber consumption can prevent proliferative diseases of the colon, the clinical data to support this hypothesis have been inconsistent. To provide a more robust measure of the effects of fiber on colonic mucosal growth than previous studies, we evaluated both cell proliferation and colonic mucosal protein synthesis in nine healthy volunteers after they consumed a typical Western diet (<20 g fiber/day) or a Western diet supplemented with wheat bran (24 g/day) in a randomized crossover design. Biopsies taken from the sigmoid colon were used to assess mucosal proliferation by determining proliferating cell nuclear antigen (PCNA) in crypt cells and to assess mucosal protein synthetic rate using stable isotopically labeled leucine infusion. Fiber supplementation produced a 12% decrease in labeling index (%crypt cells stained with PCNA) ( P < 0.001) and an 11% decrease in mucosal protein fractional synthetic rate (FSR; P < 0.05). Moreover, mucosal protein FSR correlated directly with labeling index (r2= 0.22, P < 0.05). These data demonstrate that increased wheat bran consumption decreases colonic mucosal proliferation and support the potential importance of dietary fiber in preventing proliferative diseases of the colon.
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Dissertations / Theses on the topic "Proliferation index"

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Bouchind'homme, Brigitte. "Carcinomes a cellules renales : facteurs histopronostiques, index de proliferation ki-67, cytometrie en flux et cytogenetique ; etude preliminaire a propos de 28 cas." Lille 2, 1994. http://www.theses.fr/1994LIL2M228.

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De, Brito Galvao Joao Felipe. "Antitumor effects of combined carboplatin and gemcitabine in canine transitional cell carcinoma." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305257807.

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VERSINI, PASCALE. "Calcul de l'index de proliferation cellulaire des tumeurs melaniques : melanomes, naevus de spitz et naevus dysplasiques, avec les anticorps monoclonaux anti ki et anti pcna." Saint-Etienne, 1994. http://www.theses.fr/1994STET6429.

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Cohen, Adam L., Rachel E. Factor, Kathi Mooney, Mohamed E. Salama, Mark Wade, Victoria Serpico, Emily Ostrander, et al. "POWERPIINC (PreOperative Window of Endocrine TheRapy Provides Information to Increase Compliance) trial: Changes in tumor proliferation index and quality of life with 7 days of preoperative tamoxifen." CHURCHILL LIVINGSTONE, 2017. http://hdl.handle.net/10150/622653.

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Objectives: A decrease in Ki67 during neoadjuvant therapy predicts response to tamoxifen. Previous trials have shown a decreased Ki67 in breast tumors with as little as two or more weeks of preoperative tamoxifen. Shortening the preoperative treatment time in window of opportunity clinical trials makes these trials more attractive to women. POWERPIINC examined the effect of 7 days of preoperative tamoxifen on breast tumor proliferation and patient symptoms. Methods: Women with untreated stage I/II, ER-positive, invasive breast cancer with no contraindications to tamoxifen were enrolled. Women received 20 mg of tamoxifen for 7 days up to the day of surgery. Proliferation was assessed by Ki67 immunohistochemistry before and after 7 days of tamoxifen. Symptoms and QOL were assessed by the FACT-ES and MENQOL. Adherence was measured by pill counts. Results: 52 women were enrolled, and 44 were evaluable for Ki67. The median age was 58.5 years, and the median tumor diameter was 1.2 cm. Most women (73%) were post-menopausal. Most tumors were PR positive (88%) and HER2-negative (92%). The Ki67 decreased by a geometric mean of 40% (95% CI 29%-63%), and 73% (95% CI 57%-85%) of women had tumors with decreased proliferation (p = 0.0001 by paired t-test). Adherence to taking tamoxifen during the preoperative period was 100%. Women reported minimal bother from psychosocial or physical symptoms at baseline or on the day of surgery. Conclusion: Seven days of tamoxifen showed a similar relative decrease in Ki67 as that reported for longer courses, was acceptable to women, and could be considered for window of opportunity studies.
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Jorge, Mariana Fernandes. "Caracterização histopatológica e marcadores imuno-histoquímicos no câncer de mama de gatas." Botucatu, 2016. http://hdl.handle.net/11449/139496.

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Orientador: Júlio Lopes Sequeira
Resumo: As neoplasias mamárias das gatas frequentemente são malignas e agressivas, sendo os tipos mais comuns classificados como carcinomas tubulopapilíferos, sólidos e cribriformes. O grau histológico tem relação com o comportamento biológico desses tumores. No entanto poucos estudos tem abordado a cinética celular, a expressão de marcadores epiteliais e mioepiteliais, ou mesmo de moléculas de adesão e suas relações com a agressividade tumoral. Assim, o objetivo deste trabalho foi relacionar o tipo histológico dos carcinomas mamários das gatas e seus graus histológicos com os índices proliferativos e apoptóticos, e a expressão imuno-histoquímica de CK14, alfa-SMA, E-caderina e P-caderina. Foram utilizadas 31 amostras de carcinomas mamários de gatas. Submetidas a técnica imuno-histoquímica indireta com os anticorpos Ki-67, caspase-3-clivada, CK14, alfa-SMA, E-caderina e P-caderina. Predominaram as gatas SRD, com média de idade de 12 anos. Em frequência, o percentual dos tipos histológicos foi: 42%, 45,50% e 12,50% para os carcinomas tubulopapilíferos, sólidos e cribriforme; e foi de 9,65%, 41,95% e 48,80%, para os graus I, II e III, respectivamente. Os carcinomas tubulopapilíferos mostraram índice mitótico inferior aos carcinomas sólidos, assim como os carcinomas de grau I em relação aos de grau II e III. A característica basal (CK14 +) foi frequente nesses carcinomas. O subtipo complexo (alfa-SMA + ou alfa-SMA/CK14 +/-) é raro. Houve perda da expressão de E-caderina a medida que se ... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Mammary tumors of the cats are often malignant and aggressive, the most common types classified as tubulopapillary, solid and cribriform carcinomas. The histological grade is related to the biological behavior of these tumors. However few studies have addressed the cell kinetics, the expression of epithelial and myoepithelial markers, or adhesion molecules and their relationship with tumor aggressiveness. The objective of this study was to correlate the histologic type of breast carcinomas of the cats and their histological grades with proliferative and apoptotic indices, and immunohistochemical expression of CK14, alpha-SMA, E-cadherin and Pcadherin. 31 samples of breast carcinomas cats were used. Subjected to indirect immunohistochemical technique with antibodies Ki-67, caspase-3, cleaved CK14, alpha-SMA, E-cadherin and P-cadherin. Predominated SRD cats, with a mean age of 12 years. In frequency, the percentage of histological types was 42%, 45.50% and 12.50% for tubulopapillary, solid and cribriform carcinomas; and it was 9.65%, 41.95% and 48.80% for grades I, II and III, respectively. The tubulopapillary carcinomas showed mitotic index lower than the solid carcinomas, as well as grade I carcinomas compared to levels II and III. The basal feature (CK14 +) was common in these carcinomas. The complex subtype (alpha-SMA + or alpha-SMA / CK14 +/-) is rare. There was a loss of Ecadherin expression as it becomes more aggressive. The P-cadherin was expressed high regardless of hi... (Complete abstract click electronic access below)
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Li, Lin. "Characterization of the TCOF1 Gene Using a Neuroblastoma Cell Line and a Mouse Model." Abstract, 24-page preview and downloadable full-text (PDF format) available to VCU users at:, 2006. http://proquest.umi.com/pqdweb?index=0&did=1192182461&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1179415484&clientId=4305.

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Czaykowski, Piotr Marek. "Immunobiologic prognostic factors in aggressive non-Hodgkin's lymphoma, the role of proliferative index, host-immune response, and continuous lactate dehydrogenase level in predicting survival in 148 consecutive subjects." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0015/MQ49727.pdf.

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Kasi, Loknath Kumar Anup Kumar Edgerton Mary E. Ross Michael W. Glasser Jay H. "Proliferation index in ductal carcinoma in situ of the breast : relation to estrogen, progesterone and HER2/neu receptors." 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1470187.

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Chen, Yu-An, and 陳彧安. "The Development of an Automated Analysis Program for Ki67 Proliferative Index of Neuroendocrine Tumors." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/74xh7r.

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碩士
國立陽明大學
生物醫學工程學系
106
Digital image analysis is repeatedly proposed for the assessment of Ki67 proliferative index of neuroendocrine tumors recently. It’s expected to overcome the dilemma of accuracy or efficiency encountered in several conventional methods. Unfortunately, distinguishing tumor from non-tumor is regarded as an obstacle to digital image analysis, which usually makes it over-estimation on Ki67 proliferative index. In this study, we described an automated analysis program in analyzing digital images of synaptophysin-Ki67 double stained slides. Staining synaptophysin highlights where tumor tissues are and makes it a strong feature for automated recognition. The automated analysis program we proposed is developed based on techniques of digital image processing and machine learning, and aimed to detect Ki67-positive and -negative tumor cells. Taking the Ki67 scores made by the computer-aided assessment (CAA) with an experienced pathologist as the gold standard, the outcomes made by our program showed high agreement (ICC: 0.99, 95% CI: 0.99-1.00) with CAA. And it’s significantly higher than those assessed by eyeball estimation (EE) of Ki67-only stained slides (ICC: 0.60, 95% CI: 0.45-0.73), by EE of synaptophysin-Ki67 double stained slides (ICC: 0.81, 95% CI: 0.72-0.87), and by eye-counting of pre-captured synaptophysin-Ki67 double stained slides images (ICC: 0.81, 95% CI: 0.72-0.87). As for the accuracy of single-cell detection, the sensitivities of Ki67-positive and -negative tumor cells are 0.9819 and 0.9552, while only 0.11% of false alarm toward non-tumor tissue.
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Mora, Benjamin. "The Effects of Serum from Obese Patients and Adipocyte-derived Cytokines on Growth of Prostate Cancer Cells In Vitro." Thesis, 2014. http://hdl.handle.net/1807/65589.

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Obesity has been related to a greater incidence of more aggressive, advanced stage prostate cancer. It is expected that serum adipokines related to obesity will promote a more aggressive phenotype in PC cells in vitro. Patient serum (n = 80) was obtained for analysis and divided into four patient groups based on obesity and prostate cancer status. Characteristics of serum-treated PC cells in vitro were measured. In a separate set of analyses, LNCaP and PC3 cells were treated with adiponectin and resistin in vitro, and cell characteristics were analyzed. Serum from obese PC patients induces greater amounts of cell migration and lower amounts of cell proliferation and invasion in vitro. Exogenous treatment of adiponectin on PC cells in vitro does not affect cell migration or invasion. However, adiponectin modulates cytosolic protein levels of soluble β-catenin and GSK-3β, indicating that its mechanism of action may be through the Wnt signalling pathway.
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Books on the topic "Proliferation index"

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Pučaj, Krešimir. Induction of focal proliferation of resistant hepatocytes as an index of initiation. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1992.

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S, Blanton Thomas, and National Security Archive (U.S.), eds. U.S. nuclear non-proliferation policy, 1945-1991: Guide and index. [Washington, D.C.]: National Security Archive, 1991.

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Immunobiologic prognostic factors in aggressive non-Hodgkin's lymphoma: The role of proliferative index, host-immune response, and continuous lactate dehydrogenase level in predicting survival in 148 consecutive subjects. Ottawa: National Library of Canada, 2000.

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Book chapters on the topic "Proliferation index"

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Berkefeld, Joachim, C. Lang, H. Hacker, and W. Schlote. "Grading of oligodendrogliomas: correlation of neuroradiology and proliferation index." In Proceedings of the XIV Symposium Neuroradiologicum, 20–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-49329-4_6.

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Neakrase, Samantha, and Michelle Nalabandian. "NTI Nuclear Security Index: A Model for State-Level Approaches to Nonproliferation and Arms Control." In Nuclear Non-proliferation and Arms Control Verification, 115–23. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-29537-0_8.

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Wallewein-Eising, Marten, David Broneske, and Gunter Saake. "SIMD Acceleration for Main-Memory Index Structures – A Survey." In Beyond Databases, Architectures and Structures. Facing the Challenges of Data Proliferation and Growing Variety, 105–19. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99987-6_8.

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Cannas, Mario, Sandra Biasiol, Alessandro Masse’, Alessandro Ruggeri, and Rita Strocchi. "Sister Chromatid Exchanges (SCEs) and Proliferation Rate Index (PRI): The Application of Cytogenetic Methods in Biocompatibility Field." In Bioceramics and the Human Body, 353–59. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2896-4_48.

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van Treeck, Ruben, Christian Wolter, Ian G. Cowx, Richard A. A. Noble, Myron King, Michael van Zyll de Jong, and Johannes Radinger. "Risk Assessment and Decision Making on Mitigation Measures." In Novel Developments for Sustainable Hydropower, 167–216. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-99138-8_15.

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AbstractThe proliferation of hydropower development to meet obligations under the Renewable Energy Directive has also seen the emergence of conflict between the hydropower developers and the fisheries and conservation sectors. To address this trade-off between hydroelectricity supply and its environmental costs, this chapter introduces a series of tools and guidance to assess environmental hazards of hydropower in particular on fishes, to enhance assessing cumulative effects from several hydropower schemes and to enable informed decisions on planning, development and mitigation of new and refurbished hydropower schemes. The newly developed European Fish Hazard Index is introduced as objective, comparable, and standardized screening tool for assessing the impacts on fishes at existing and planned hydropower schemes, while explicitly considering the ecological status and consecration value of the ambient fish assemblage. In addition, guidance is provided on assessing the environmental impacts of consecutive hydropower schemes in a river system. This guidance separates between cumulative impacts on habitats and species and thus, considers cumulative length of all impoundments in a river system, total fragmentation by barriers (barrier density), but also different migratory life history traits of species and their encounter probability with hydropower schemes and sensitivity to mortality. Finally, a decision support scheme is provided to balance the environmental risk with appropriate, site-specific mitigation planning and implementation at new and existing hydropower schemes.
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"Index." In Control of Animal Cell Proliferation, 545–57. Elsevier, 1985. http://dx.doi.org/10.1016/b978-0-12-123061-6.50023-1.

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"Index." In Control of Animal Cell Proliferation, 499–510. Elsevier, 1987. http://dx.doi.org/10.1016/b978-0-12-123062-3.50023-2.

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"Index." In Over the Horizon Proliferation Threats, 307–15. Stanford University Press, 2020. http://dx.doi.org/10.1515/9780804783729-017.

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"Index." In Forecasting Nuclear Proliferation in the 21st Century, 281–96. Stanford University Press, 2010. http://dx.doi.org/10.1515/9781503627437-013.

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"INDEX." In Forecasting Nuclear Proliferation in the 21st Century, 447–72. Stanford University Press, 2010. http://dx.doi.org/10.1515/9781503627420-018.

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Conference papers on the topic "Proliferation index"

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Fujimura, Koji, Satoshi Itooka, and Takeshi Nitawaki. "Fast Breeder Reactor Core Concept to Improve Nuclear Proliferation Resistance." In 18th International Conference on Nuclear Engineering. ASMEDC, 2010. http://dx.doi.org/10.1115/icone18-29214.

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A sodium-cooled MOX-fueled FBR core concept to improve nuclear proliferation resistance was proposed. First, we set an index for the nuclear proliferation resistance. In a previous study, reactor-grade Pu was defined such that the Pu-240 isotopic ratio was larger than 18%. Another study defined nuclear proliferation resistance with the Pu-238 isotopic ratio considering its higher spontaneous fission rate and decay heat. We tentatively use the total isotope composition ratio of Pu-238 and Pu-240 as a proliferation resistance index in line with the earlier studies. Next, we designed the sodium-cooled mixed-oxide (MOX)-fueled core concept with the breeding ratio (BR) of over 1.1 without a radial blanket. To attain the index for nuclear proliferation resistance, we added minor actinides (MAs) to the axial blanket fuel (AB). Contents of MAs in the AB to achieve the proliferation resistance index were evaluated. For the case of Np as a representative MA, the minimum content of Np to achieve the index was 3%. And, for the case of loading all MAs, the minimum content of MAs was 10.5%.
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Ozkaraca, Osman, Yelda Dere, Gurcan Cetin, and Musa Peker. "A computer aided system for calculation of Ki-67 proliferation index." In 2017 International Conference on Computer Science and Engineering (UBMK). IEEE, 2017. http://dx.doi.org/10.1109/ubmk.2017.8093470.

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Funari, Abigail, Maximilian C. Stahl, Andre E. Boyke, Ankita Naraparaju, Kevin A. Hsu, and Vijay Agarwal. "Imaging Indicators of High KI-67 Proliferation Index in Pituitary Macroadenomas." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743797.

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Chakraborty, Amlan, V. R. Jala, H. Bodduluri, M. Keith Sharp, and R. Eric Berson. "Effects of Directional Oscillatory Shear Index on Endothelial Cell Proliferation and Morphology." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19626.

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The effects of hemodynamic forces on cellular responses have been studied for the last three decades. Wall shear stresses (WSS) are commonly accepted as an important factor affecting anchored cells subjected to fluid flow [1, 2]. Parallel plate flow chambers and cone and plate apparatuses, which are commonly used to generate controlled shear, are limited in that only one experimental condition can be explored at a time. On the other hand, orbital shakers can be used to investigate several cases simultaneously since many culture dishes can fit on its platform. A remaining challenge, however, is that shear generated in dishes on orbital shakers is two-dimensional, nonuniform and is oscillatory in nature, and can be described analytically [3, 4] for only a few limited conditions. In this project, computational fluid dynamics (CFD) is applied to overcome those limitations by modeling the fluid flow in an orbiting petri dish for a range of conditions. In addition, cells grown under the same flow conditions were monitored for proliferation and morphology. A new directional oscillatory shear index (DOSI) is proposed to quantify the bidirectionality of oscillating shear. Cell proliferation, area, shape index and aspect ratio were investigated for different DOSI at different shear magnitudes.
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Beyhan Sagmen, Seda, Coskun Dogan, Sevda Comert, Nesrin Kiral, Elif Torun Parmaksiz, Ali Fidan, Nagehan Ozdemir Barisik, and Sule Karabulut Gul. "The importance of Ki-67 proliferation index in small cell lung cancer." In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.1732.

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6

Han, Hai-Chao, Raymond P. Vito, Kristin Michael, and David N. Ku. "Axial Stretch Increases Cell Proliferation in Arteries in Organ Culture." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2516.

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Abstract To study the effect of axial stretch on vascular function and wall remodeling, porcine carotid arteries were cultured under conditions of physiological flow and elevated axial stretch in an ex vivo organ culture system. Smooth muscle cell proliferation was measured by bromodeoxyuridine index. Results showed that cell proliferation was significantly increased in the highly stretched arteries when compared to the normally stretched arteries. This may indicate the feasibility of stimulating new arterial growth by stretching natural arteries.
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Mikheeva, N. A., E. P. Drozhdina, and N. A. Kurnosova. "Morphofunctional features of proliferating cells exposed to PSMA peptide." In VIII Vserossijskaja konferencija s mezhdunarodnym uchastiem «Mediko-fiziologicheskie problemy jekologii cheloveka». Publishing center of Ulyanovsk State University, 2021. http://dx.doi.org/10.34014/mpphe.2021-142-144.

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The effect of the synthetic PSMA peptide on dividing cells of laboratory animals was studied. The experiment was carried out on male white laboratory mice of the BALB/c-line. The toxic effect of PSMA peptidi was evaluated at therapeutic (1.4 μg / kg of animal weight or 0.04 μg / animal) and subtoxic (140 μg / kg of animal weight or 4.0 μg / animal) doses. The cytotoxic effect of PSMA peptide on red bone marrow cells and cambial intestinal cells of the of laboratory mice was determined. A decrease in the proliferative activity of the colon crypt cells was revealed upon administration of a subtoxic dose of the PSMA peptide and there were no signs of toxic damage to the red bone marrow cells of animals. Key words: toxicity, proliferation, synthetic peptides, mitotic index, micronucleus test.
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Cristofoletti, Cristina, Mario Picozza, Antonella Bresin, Maria Cristina Picchio, Enrico Scala, Giuseppe A. Lombardo, Francesca Passarelli, Elisabetta Caprini, Giandomenico Russo, and Maria Grazia Narducci. "Abstract 936: Skin microenvironment enhances proliferation index and activates mTORC 1 signaling in sezary syndrome." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-936.

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Nguyen, Minh P., Ramin A. Morshed, Cecilia L. Dalle Ore, Daniel D. Cummins, Satvir Saggi, Stephen T. Magill, Michael W. McDermott, and Philip V. Theodosopoulos. "Proliferation Index Correlates with Long-Term Recurrence after Complete Resection of WHO Grade-I Meningioma." In 31st Annual Meeting North American Skull Base Society. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1743636.

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10

Singhal, S., P. Bedard, M. Ignatiadis, B. Haibe-Kains, C. Desmedt, S. Loi, D. Evans, J. Dixon, W. Miller, and C. Sotiriou. "Early Assessment of Proliferation by the Genomic Grade Index (GGI) Predicts Response to Neo-Adjuvant Letrozole." In Abstracts: Thirty-Second Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 10‐13, 2009; San Antonio, TX. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-09-2016.

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