Journal articles: 'Projection-specific lesion'

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Belozerskikh, K. A., O. E. Egorov, G. Yu Evzikov, and T. I. Shadyzheva. "Puncture technologies in the treatment of pain syndrome caused by sacroiliac joint dysfunction." Neurology, Neuropsychiatry, Psychosomatics 12, no. 4 (August 27, 2020): 32–36. http://dx.doi.org/10.14412/2074-2711-2020-4-32-36.

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Sacroiliac joint (SIJ) dysfunction is a cause of low back pain in 10–30% of cases. In 1993, the International Association for the Study of Pain (IASP) defined the following set of diagnostic criteria necessary to diagnose SIJ dysfunction: 1) the presence of pain in the areas characteristic of SIJ lesions, with special attention to pain in the Fortin area projection, with possible different types of radiation; 2) positive pain provocation tests for a SIJ lesion; 3) reduced pain after intra-articular anesthetic injection; 4) the lack of a specific nature of the lesion (fracture, inflammation, tumor, etc.). Injection of 0.5–2.5 ml of solution of an anesthetic (bupivacaine, lidocaine) and 20–40 mg of triamcinolone or 5 mg of betamethasone (1 ml) into the SIJ area is used as interventional technologies. More prolonged analgesia involves radiofrequency denervation (RFD) of the SIJ, in which needles with electrodes are placed in the projection of the nerves that innervate the SIJ, and their local thermal destruction is performed. The effectiveness of RFD of SIJ requires further investigation.

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Berg, D., T. Supprian, J. Thomae, M. Warmuth-Metz, A. Horowski, B. Zeiler, T. Magnus, P. Rieckmann, and G. Becker. "Lesion pattern in patients with multiple sclerosis and depression." Multiple Sclerosis Journal 6, no. 3 (June 2000): 156–62. http://dx.doi.org/10.1177/135245850000600304.

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To assess if a specific lesion pattern or changes of the basal limbic system as seen in primary depression and depression associated with neurodegenerative disorders might be identified in depressive multiple sclerosis (MS) patients, we submitted 78 MS patients to a MRI examination consisting of a quantitative measurement of lesions and of hyperintense signals from the pontomesencephalic midline (raphe). Furthermore relaxometry of the pontomesencephalic midline, a transcranial ultrasound examination rating its echogenicity semiquantitatively and a standardized neurological, neuropsychiatric and neuropsychological assessment were obtained. Thirty-one patients fulfilled the DSM-IV criteria for depression. Depressed MS patients had a significantly larger temporal lesion load than non-depressed MS patients, especially on the right side. A trend of difference was detected for lesions of the right parietal lobe, the right frontal lobe, the cerebellum and the total lesion load. Neither hyperintense signals or relaxometry nor echogenicity of the region at the level of the pontomesencephalic midline were significantly different between the groups. We conclude that depression in MS patients is not associated with an alteration of the basal limbic system at the brainstem as seen in Parkinson's disease or unipolar depression but with an increased lesion load of the projection areas of the basal limbic system.

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Rosenau, B. J., A. S. Greenberg, J. S. Sunness, and S. Yantis. "Cortical lesion projection zone activity in retinal disease patients is caused by object-specific feedback, not plasticity." Journal of Vision 8, no. 6 (March 29, 2010): 490. http://dx.doi.org/10.1167/8.6.490.

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Squair, Jordan W., Marco Milano, Alexandra de Coucy, Matthieu Gautier, Michael A. Skinnider, Nicholas D. James, Newton Cho, et al. "Recovery of walking after paralysis by regenerating characterized neurons to their natural target region." Science 381, no. 6664 (September 22, 2023): 1338–45. http://dx.doi.org/10.1126/science.adi6412.

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Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing to identify neuronal subpopulations that restore walking after incomplete SCI. We show that chemoattracting and guiding the transected axons of these neurons to their natural target region led to substantial recovery of walking after complete SCI in mice, whereas regeneration of axons simply across the lesion had no effect. Thus, reestablishing the natural projections of characterized neurons forms an essential part of axon regeneration strategies aimed at restoring lost neurological functions.

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Norrsell, U., and A. D. Craig. "Behavioral Thermosensitivity After Lesions of Thalamic Target Areas of a Thermosensory Spinothalamic Pathway in the Cat." Journal of Neurophysiology 82, no. 2 (August 1, 1999): 611–25. http://dx.doi.org/10.1152/jn.1999.82.2.611.

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The ability of 17 cats to discriminate floor temperatures 2–4°C below the ambient temperature was tested before and after unilateral electrolytic thalamic lesions. The lesions were made contralateral to the paws showing better performance in the temperature discrimination task. They were aimed at one or more of the three main target areas of thermoreceptive-specific lamina I spinothalamic neurons [i.e., the nucleus submedius, the dorsomedial aspect of the ventral posterior medial nucleus, and the ventral aspect of the basal ventral medial nucleus (vVMb)], following microelectrode mapping of somatosensory thalamus. The thermosensory consequences of each lesion were measured in postoperative testing, beginning 6–8 days after the final preoperative test session. A mild but definite thermosensory deficiency was found in five cats, in which the response behavior on the contralateral side was reduced below the 69% criterion level for several sessions. Histological analysis indicated that these cats differed only by the inclusion in the lesion of all or part of vVMb. Consequently this area appears to be important for cats’ thermosensory behavior. Nevertheless even large lesions of virtually all of the thermoreceptive lamina I spinothalamic projection areas produced only this mild thermosensory deficit in stark contrast with the massive defect observed previously after spinal lesions of the middle of the lateral funiculus, where lamina I axons ascend. Accordingly such spinal lesions were added at the C4 level, on the same side as the thalamic lesions, in six cats 3 mo after the thalamic surgery. These lesions caused severe contralateral defects (i.e., chance level performance). Thus the present findings are taken to indicate that contralateral ascending projections to vVMb in the thalamus participate in cats’ thermosensory discrimination but that ascending projections to the brain stem must play an important role in their behavioral thermosensitivity.

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Ghosh, A., and C. J. Shatz. "A role for subplate neurons in the patterning of connections from thalamus to neocortex." Development 117, no. 3 (March 1, 1993): 1031–47. http://dx.doi.org/10.1242/dev.117.3.1031.

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During cerebral cortical development, ingrowing axons from different thalamic nuclei select and invade their cortical targets. The selection of an appropriate target is first evident even before thalamic axons grow into the cortical plate: initially axons accumulate and wait below their cortical target area in a zone called the subplate. This zone also contains the first postmitotic neurons of the cerebral cortex, the subplate neurons. Here we have investigated whether subplate neurons are involved in the process of target selection by thalamic axons by ablating them from specific cortical regions at the onset of the waiting period and examining the subsequent thalamocortical axon projection patterns. Subplate neurons were ablated at the onset of the waiting period by intracortical injections of kainic acid. The effect of the ablation on the thalamocortical projection from visual thalamus was examined by DiI-labeling of the LGN days to weeks following the lesion. At two to four weeks post-lesion, times when LGN axons would have normally invaded the cortical plate, the axons remained below the cortical plate and grew past their appropriate cortical target in an anomalous pathway. Moreover, examination of LGN axons at one week post-lesion, a time when they would normally be waiting and branching within the visual subplate, indicated that the axons had already grown past their correct destination. These observations suggest that visual subplate neurons are involved in the process by which LGN axons select and subsequently grow into visual cortex. In contrast, subplate neurons do not appear to play a major role in the initial morphological development of the LGN itself. Subplate ablations did not alter dendritic growth or shapes of LGN projection neurons during the period under study, nor did it prevent the segregation of retinal ganglion cell axons into eye-specific layers. However, the overall size of the LGN was reduced, suggesting that there may be increased cell death of LGN neurons in the absence of subplate neurons. To examine whether subplate neurons beneath other neocortical areas play a similar role in the formation of thalamocortical connections, subplate neurons were deleted beneath auditory cortex at the onset of the waiting period for auditory thalamic axons. Subsequent DiI labeling revealed that in these animals the majority of MGN axons had grown past auditory cortex instead of innervating it. Taken together these observations underscore a general requirement for subplate neurons throughout neocortex in the process of cortical target selection and ingrowth by thalamic axons.(ABSTRACT TRUNCATED AT 400 WORDS)

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Cuesta Urquia, Carolina, AD Moreiras Sánchez, MM Pampín Martínez, A. Fernández García, N. Montesdeoca García, and JL Cebrián Carretero. "Surface scanning and 3D printing for optimized partial auricular reconstruction." Journal of Dermatology & Cosmetology 7, no. 4 (December 26, 2023): 154–56. http://dx.doi.org/10.15406/jdc.2023.07.00253.

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We present the resolution of a case of a 50-year-old patient who presented for excision and reconstruction of a malignant skin lesion at the auricular tubercle of the right helix. The patient reported great concern for the aesthetic outcome. The auricular helix has a unique projection, relief, consistency, and size determined by the contralateral side. Its reconstruction is a surgical challenge and requires sophisticated techniques to achieve good results. Therefore, in cases where we are looking for precision and predictability, 3D technology is a great help for the surgeon as it allows pre-surgical patient-specific planning and the printing of sterilisable models that serve as surgical 3D guides. This case was solved with a two-stage reconstruction. First, the lesion was excised, and a retro auricular advancement flap was placed. In the second stage, the placement of cartilage was sectioned using a customised surgical model obtained from the scanning of the contralateral ear surface. This way, the cartilage donor area was optimised, choosing the most similar shape and size with great precision.

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Noël, Peter B., Stephan Engels, Thomas Köhler, Daniela Muenzel, Daniela Franz, Michael Rasper, Ernst J. Rummeny, Martin Dobritz, and Alexander A. Fingerle. "Evaluation of an iterative model-based CT reconstruction algorithm by intra-patient comparison of standard and ultra-low-dose examinations." Acta Radiologica 59, no. 10 (January 10, 2018): 1225–31. http://dx.doi.org/10.1177/0284185117752551.

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Background The explosive growth of computer tomography (CT) has led to a growing public health concern about patient and population radiation dose. A recently introduced technique for dose reduction, which can be combined with tube-current modulation, over-beam reduction, and organ-specific dose reduction, is iterative reconstruction (IR). Purpose To evaluate the quality, at different radiation dose levels, of three reconstruction algorithms for diagnostics of patients with proven liver metastases under tumor follow-up. Material and Methods A total of 40 thorax–abdomen–pelvis CT examinations acquired from 20 patients in a tumor follow-up were included. All patients were imaged using the standard-dose and a specific low-dose CT protocol. Reconstructed slices were generated by using three different reconstruction algorithms: a classical filtered back projection (FBP); a first-generation iterative noise-reduction algorithm (iDose4); and a next generation model-based IR algorithm (IMR). Results The overall detection of liver lesions tended to be higher with the IMR algorithm than with FBP or iDose4. The IMR dataset at standard dose yielded the highest overall detectability, while the low-dose FBP dataset showed the lowest detectability. For the low-dose protocols, a significantly improved detectability of the liver lesion can be reported compared to FBP or iDose4 ( P = 0.01). The radiation dose decreased by an approximate factor of 5 between the standard-dose and the low-dose protocol. Conclusion The latest generation of IR algorithms significantly improved the diagnostic image quality and provided virtually noise-free images for ultra-low-dose CT imaging.

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Liew, Alex, Sos Agaian, and Samir Benbelkacem. "Distinctions between Choroidal Neovascularization and Age Macular Degeneration in Ocular Disease Predictions via Multi-Size Kernels ξcho-Weighted Median Patterns." Diagnostics 13, no. 4 (February 14, 2023): 729. http://dx.doi.org/10.3390/diagnostics13040729.

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Age-related macular degeneration is a visual disorder caused by abnormalities in a part of the eye’s retina and is a leading source of blindness. The correct detection, precise location, classification, and diagnosis of choroidal neovascularization (CNV) may be challenging if the lesion is small or if Optical Coherence Tomography (OCT) images are degraded by projection and motion. This paper aims to develop an automated quantification and classification system for CNV in neovascular age-related macular degeneration using OCT angiography images. OCT angiography is a non-invasive imaging tool that visualizes retinal and choroidal physiological and pathological vascularization. The presented system is based on new retinal layers in the OCT image-specific macular diseases feature extractor, including Multi-Size Kernels ξcho-Weighted Median Patterns (MSKξMP). Computer simulations show that the proposed method: (i) outperforms current state-of-the-art methods, including deep learning techniques; and (ii) achieves an overall accuracy of 99% using ten-fold cross-validation on the Duke University dataset and over 96% on the noisy Noor Eye Hospital dataset. In addition, MSKξMP performs well in binary eye disease classifications and is more accurate than recent works in image texture descriptors.

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Takahashi, Wataru, Shota Oshikawa, and Shinichiro Mori. "Real-time markerless tumour tracking with patient-specific deep learning using a personalised data generation strategy: proof of concept by phantom study." British Journal of Radiology 93, no. 1109 (May 1, 2020): 20190420. http://dx.doi.org/10.1259/bjr.20190420.

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Objective: For real-time markerless tumour tracking in stereotactic lung radiotherapy, we propose a different approach which uses patient-specific deep learning (DL) using a personalised data generation strategy, avoiding the need for collection of a large patient data set. We validated our strategy with digital phantom simulation and epoxy phantom studies. Methods: We developed lung tumour tracking for radiotherapy using a convolutional neural network trained for each phantom’s lesion by using multiple digitally reconstructed radiographs (DRRs) generated from each phantom’s treatment planning four-dimensional CT. We trained tumour-bone differentiation using large numbers of training DRRs generated with various projection geometries to simulate tumour motion. We solved the problem of using DRRs for training and X-ray images for tracking using the training DRRs with random contrast transformation and random noise addition. Results: We defined adequate tracking accuracy as the percentage frames satisfying <1 mm tracking error of the isocentre. In the simulation study, we achieved 100% tracking accuracy in 3 cm spherical and 1.5×2.25×3 cm ovoid masses. In the phantom study, we achieved 100 and 94.7% tracking accuracy in 3 cm and 2 cm spherical masses, respectively. This required 32.5 ms/frame (30.8 fps) real-time processing. Conclusions: We proved the potential feasibility of a real-time markerless tumour tracking framework for stereotactic lung radiotherapy based on patient-specific DL with personalised data generation with digital phantom and epoxy phantom studies. Advances in knowledge: Using DL with personalised data generation is an efficient strategy for real-time lung tumour tracking.

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Stepchenkov, Roman Petrovich. "Varicose veins — the relevance of the problem." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 4 (March 23, 2022): 25–30. http://dx.doi.org/10.33920/med-10-2204-04.

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Varicose disease is one of the most common vascular diseases; according to some authors, its manifestations are observed to some extent in 89 % of women and 66 % of men. The basis of this pathology is a violation of the normal operation of the vascular valves, resulting in a return of venous blood, followed by vasodilation and overstretching of the vascular wall. The disease begins imperceptibly and can develop gradually over several years and even decades. As a rule, in women, the onset of the disease occurs during pregnancy. The initial signs of the disease are not specific: the feeling of heaviness in the legs, especially pronounced in the evening, pain in the calf muscles, convulsions sometimes occur at night. One of the most common signs includes swelling in the area of the ankle joints, more pronounced in the evening and passing after a night's rest. All these signs are aggravated after a long stay in an upright position, especially in the hot season. This symptom complex is called «heavy legs syndrome». In the absence of treatment in the elderly, trophic ulcers may appear in the projection of the lesion. Surgical intervention is considered the most radical and effective method of treatment; the share of operations for this pathology is about 3–4 % of the total number of surgical interventions. Preventive treatment includes wearing compression garments, controlling body weight, normalizing work and rest balance, avoiding heavy lifting and prolonged static loads.

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Tseng, Shih-Chiao, and Susanne M. Morton. "Impaired Interlimb Coordination of Voluntary Leg Movements in Poststroke Hemiparesis." Journal of Neurophysiology 104, no. 1 (July 2010): 248–57. http://dx.doi.org/10.1152/jn.00906.2009.

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Appropriate interlimb coordination of the lower extremities is particularly important for a variety of functional human motor behaviors such as jumping, kicking a ball, or simply walking. Specific interlimb coordination patterns may be especially impaired after a lesion to the motor system such as stroke, yet this has not been thoroughly examined to date. The purpose of this study was to investigate the motor deficits in individuals with chronic stroke and hemiparesis when performing unilateral versus bilateral inphase versus bilateral antiphase voluntary cyclic ankle movements. We recorded ankle angular trajectories and muscle activity from the dorsiflexors and plantarflexors and compared these between subjects with stroke and a group of healthy age-matched control subjects. Results showed clear abnormalities in both the kinematics and EMG of the stroke subjects, with significant movement degradation during the antiphase task compared with either the unilateral or the inphase task. The abnormalities included prolonged cycle durations, reduced ankle excursions, decreased agonist EMG bursts, and reduced EMG modulation across movement phases. By comparison, the control group showed nearly identical performance across all task conditions. These findings suggest that stroke involving the corticospinal system projection to the leg specifically impairs one or more components of the neural circuitry involved in lower extremity interlimb coordination. The express susceptibility of the antiphase pattern to exaggerated motor deficits could contribute to functional deficits in a number of antiphase leg movement tasks, including walking.

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Senko, I. V., E. S. Ryzhkova, O. I. Patsap, and M. B. Dolgushin. "Isolated cerebral varices: clinical observations and literature review." Russian journal of neurosurgery 25, no. 4 (January 27, 2024): 79–86. http://dx.doi.org/10.17650/1683-3295-2023-25-4-79-86.

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The aim of the study is to present rare clinical cases of isolated cerebral varices, summarize scientific literature data on their diagnosis and treatment.The article describes 2 clinical observations of isolated cerebral varix, presents a literature review of this topic, as well as treatment tactics for patients with this pathology.In the first clinical observation, in a male 72‑year-old patient isolated cerebral varix was interpreted as distal saccular aneurysm of the right middle cerebral artery per computed angiography data. Surgical treatment was performed: from subtemporal approach in the area of the floor of the middle cranial fossa, cerebral varix, inflow and outflow veins were visualized. The inflow and outflow veins were clipped, aneurysm was resected and sent to histological examination. The patient was discharged on day 8 after surgery. Histological examination of the cerebral varix wall showed typical components for a venous wall, in particular, individual smooth muscle fibers, absence of elastic membrane.In the second clinical observation, in a female 59‑year-old patient magnetic resonance (MR) imaging, MR angiography and MR venography in the projection of anterior basal parts of the left temporal area showed an aneurysmal malformation transitioning into the superficial middle cerebral vein. Taking into consideration venous pathogenesis of the vascular lesion, dynamic observation of the patient was chosen.Isolated cerebral varix is a rare vascular pathology without a specific clinical and instrumental picture. To avoid erroneous diagnosis and determine further treatment tactics, additional examinations are recommended: MR imaging, MR angiography and MR venography.

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Wibowo Nurcahyo, Panji, Merliana Devina, Akhmad Haris Sulistiyadi, and Siti Daryati. "INFORMASI DIAGNOSTIK GAMBARAN RADIOGRAF CERVICAL HASIL MULTIPLANAR RECONSTRUCTION CT-SCAN KEPALA." JRI (Jurnal Radiografer Indonesia) 4, no. 2 (November 29, 2021): 86–88. http://dx.doi.org/10.55451/jri.v4i2.94.

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ABSTRACT Introduction : Data at Kenyatta National Hospital (KNH) from 2012 to 2016 recorded that there were 1,432 patients with a head injury diagnosis. Of the patients diagnosed with moderate or severe head injury, 11 (3.07%) patients had head and neck injuries. The clinical pathway in the diagnosis of head injury, CT-Scan of the brain (preferably with the inclusion of the cervical vertebrae) is now the rule in assessing traumatic brain injury. At the Radiology Installation of the Salatiga City Hospital, a head CT scan with a head injury diagnosis used a scan of the area from cervical 7 to the vertex, then cervical radiographs were made using MPR. Methods : This study uses a qualitative method with a case study approach. Data collection was carried out in March 2020 by direct observation, in-depth interviews, and documentation studies.Results : Patients diagnosed with CKS and CKB were shown cervical MPR. This MPR image has no superposition, which usually shows cervical 1 and 2 superposition with the mandible even at an angle, and in the lateral projection, cervical 7 superposition with the shoulder. The disadvantage is that the radiation dose received by the patient increases, but on radiological examination there is a justification principle, namely even though using a CT-Scan with greater radiation, the benefits obtained are also greater. In addition, burst fractures can be seen on cervical radiographs from MPR. There are fractures in trauma victims that are not fully demonstrated on radiographs at cervical 1 to cervical 2, cervical 6 to 7 cervical levels, and most involve the transverse process because the patient is uncooperative. Helical CT scanning can depict significant fractures that cannot be demonstrated on conventional radiographs and should be added to the initial screening for suspected cervical trauma.Conclusion : The cervical MPR image aims to obtain four cervical projections, namely AP, lateral, right oblique, and left oblique without conventional projections with the aim of minimizing movement in patients who are at risk of aggravating spinal cord injury. Diagnostic information from MPR results is to obtain structural visualization. specific, determine the extent of the lesion, localize the lesion and bone fragments. However, the radiation dose received is greater than conventional radiographic examinations.

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He, Jufang. "Modulatory Effects of Regional Cortical Activation on the Onset Responses of the Cat Medial Geniculate Neurons." Journal of Neurophysiology 77, no. 2 (February 1, 1997): 896–908. http://dx.doi.org/10.1152/jn.1997.77.2.896.

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He, Jufang. Modulatory effects of regional cortical activation on the onset responses of the cat medial geniculate neurons. J. Neurophysiol. 77: 896–908, 1997. Corticofugal modulation on activity of the medial geniculate body (MGB) was examined by locally activating the primary auditory cortex (AI) and looking for effects on the onset responses of MGB neurons to acoustic stimuli. Of 103 MGB neurons recorded from 13 hemispheres of 11 animals, 91 neurons (88%) showed either a facilitatory or inhibitory effect or both; of these neurons, 72 showed facilitatory effects and 25 inhibitory effects. The average facilitatory effect was large, with a mean increase of 62.4%. Small inhibitory effects (mean: −16.2%) were obtained from a few neurons (6 of 103) when a pure tone stimulus was used, whereas the effect became larger and more frequent when a noise burst stimulus was used (mean: −27.3%, n = 22 of 27 neurons). Activation of an AI site having the same best frequency (BF) as the MGB neuron being recorded from produced mainly a facilitatory effect on MGB neuronal responses to pure tones. Activation of AI at a site neighboring the BF site produced inhibitory effects on the MGB response when noise burst stimuli were used. We found that the effective stimulation sites in AI that could modulate MGB activity formed patchlike maps with a diameter of 1.13 ± 0.09 (SE) mm (range 0.6–1.9 mm, n = 15) being larger than the patches of thalamocortical terminal fields. Examining the effects of sound intensities, of 18 neurons tested 9 neurons showed a larger effect for low-sound-intensity stimuli and small or no effects for high-sound-intensity stimuli. These were named low-sound-intensity effective neurons. Five neurons showed high sound intensity effectiveness and four were non-intensity specific. Most low-sound-intensity effective neurons were monotonic rate-intensity function neurons. The AI cortical modulatory effect was frequency specific, because 15 of 27 neurons showed a larger facilitatory effect when a BF stimulus was used rather than a stimulus of any other frequency. The corticothalamic connection between the recording site in MGB and the most effective stimulation site in AI was confirmed by injecting wheat germ agglutinin–horseradish peroxidase tracer at the stimulation site and producing a small lesion in the recording site. The results suggest that 1) the large facilitation effects obtained by AI activation at the region that directly projected to the MGB could be the result mainly of the direct projection terminals to the MGB relay neurons; 2) the large size patches of the effective stimulation site in AI could be due to widely ramifying corticothalamic projections; and 3) the corticofugal projection selectively gates auditory information mainly by a facilitatory effect, although there is also an inhibitory effect that depends on the sound stimulus used.

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Arensmeyer, Jan, Benedetta Bedetti, Philipp Schnorr, Jens Buermann, Donatas Zalepugas, Joachim Schmidt, and Philipp Feodorovici. "A System for Mixed-Reality Holographic Overlays of Real-Time Rendered 3D-Reconstructed Imaging Using a Video Pass-through Head-Mounted Display—A Pathway to Future Navigation in Chest Wall Surgery." Journal of Clinical Medicine 13, no. 7 (April 3, 2024): 2080. http://dx.doi.org/10.3390/jcm13072080.

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Background: Three-dimensional reconstructions of state-of-the-art high-resolution imaging are progressively being used more for preprocedural assessment in thoracic surgery. It is a promising tool that aims to improve patient-specific treatment planning, for example, for minimally invasive or robotic-assisted lung resections. Increasingly available mixed-reality hardware based on video pass-through technology enables the projection of image data as a hologram onto the patient. We describe the novel method of real-time 3D surgical planning in a mixed-reality setting by presenting three representative cases utilizing volume rendering. Materials: A mixed-reality system was set up using a high-performance workstation running a video pass-through-based head-mounted display. Image data from computer tomography were imported and volume-rendered in real-time to be customized through live editing. The image-based hologram was projected onto the patient, highlighting the regions of interest. Results: Three oncological cases were selected to explore the potentials of the mixed-reality system. Two of them presented large tumor masses in the thoracic cavity, while a third case presented an unclear lesion of the chest wall. We aligned real-time rendered 3D holographic image data onto the patient allowing us to investigate the relationship between anatomical structures and their respective body position. Conclusions: The exploration of holographic overlay has proven to be promising in improving preprocedural surgical planning, particularly for complex oncological tasks in the thoracic surgical field. Further studies on outcome-related surgical planning and navigation should therefore be conducted. Ongoing technological progress of extended reality hardware and intelligent software features will most likely enhance applicability and the range of use in surgical fields within the near future.

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Grechanyk, O. I., O. S. Gerasimenko, R. Ya Abdullayev, I. A. Lurin, K. V. Humeniuk, V. V. Negoduyko, D. O. Slesarenko, N. B. Alekseeva, and M. S. Sudmak. "CLINICAL AND DIAGNOSTIC ASPECTS OF FIRE I NFLAMMATION INJURIES OF HOLLOW ABDOMINAL ORGANS (ATO / OOS EXPERIENCE)." Kharkiv Surgical School, no. 1 (February 20, 2022): 71–81. http://dx.doi.org/10.37699/2308-7005.1.2022.13.

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Among the features of radiological diagnosis for the wounded with injuries of the gastrointestinal tract, we can point to a set of radiological methods of research, among which the leading place is occupied by X-ray contrast studies of the abdomen — vulnerography, fistulography, enterography, irigoscopy. The most important task of special methods of X-ray examination of gastrointestinal injuries, accompanied by the introduction of X-ray contrast agents, is the control of the postoperative period, radiological support during surgery and diagnosis of failure of sutures, anastomoses, intraperitoneal walls fistula, phlegmon of retroperitoneal tissue. Materials and methods. The results of retrospective analysis of radiological diagnostics of 76 (7.5 ± 1.6) % of wounded in the abdomen, waist, retroperitoneal space from the total mass of subjects (n = 1013 people), due to the mechanical and multifactorial nature of the lesion. Of these, 42 subjects with a predominant abdominal component of gastric injury injuries were in 6 cases out of 42 (14.3 %), 3 (7.1 %) cases of esophageal and duodenal injuries, small bowel injuries were observed in 12 cases (28, 6 %), colon damage in 14 cases (33.4 %) and rectal damage in 4 cases (9.5 %). All X-ray contrast studies of different parts of the digestive tract were performed with one-time double contrast and other methods in the X-ray diagnostic department of the clinic (radiation diagnostics and therapy) of the National Military Medical Clinical Center «GVKG» on modern X-ray machine expert class OPERA SWING. Discussion of results. There are no fundamental differences in the tactics of radiation control of injuries (TCU) of the gastrointestinal tract in abdominal injuries. However, in the preoperative period of urgent radiological diagnosis of damage to the esophagus, stomach, small, colon, and other parts of the colon, preference is given to non-contrast radiological examination of the abdomen (review radiography in direct projection standing / lying, lateroposition and lateral projection). In the future, the postoperative period of the wounded is accompanied by the widespread use of X-ray contrast studies of internal organs with gastrointestinal damage for radiation support during surgery and diagnosis of complications in the early and late postoperative periods. Conclusions. Given the multiple and combined nature of gunshot and non-gunshot injuries to the abdomen, lower back, retroperitoneal space in the wounded with injuries of the esophagus, stomach, small, colon and other parts of the colon, immediate radiological diagnosis should be provided to all wounded. preoperative period to address the clinical and diagnostic problem of emergencies. Since the natural X-ray contrast of the abdominal cavity and retroperitoneal space is very low, and damaged hollow organs increase pneumatization of the gastrointestinal tract, the use of artificial contrast (barium mixture, iodine-containing water-soluble X-ray contrast agents) significantly increases the diagnostic value. The use of special methods of X-ray examination with artificial contrast in the postoperative period is determined by the condition of the wounded and the specific clinical situation.

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Korol, P., and M. Tkachenko. "DIAGNOSTIC ROLE OF BONE SCINTIGRAPHY IN EARLY PROGNOSIS OF PARAENDOPROSTHETIC COMPLICATIONS IN ARTHROPLASTY OF HIP AND KNIEE JOINTS." Likarska sprava, no. 7-8 (December 30, 2018): 73–78. http://dx.doi.org/10.31640/jvd.7-8.2018(12).

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For 10 years, we studied the diagnostic role of three-phase bone scintigraphy (3-f BS) in the early prognosis of paraendoprosthetic complications in patients with degenerative-dystrophic and infectious-inflammatory diseases of the hip and knee joints. Using 3-f BS, the kinetic radionuclide parameters of inclusion and distribution of radiopharmaceutical (RP) in the projection of affected joints were evaluated. It was determined that the kinetics of osteotropic RP in the foci of fixation of affected joints in infectious and inflammatory processes is characterized by the predominance of retention and specific accumulation of the drug in the early and delayed static phase of 3-f BS in comparison with foci of fixing RP in degenerative-dystrophic lesions, which correlates with the differences destructively-reparative processes in them.According to the results of the analysis of the kinetic parameters, a radionuclide model of the dynamics of inclusion and distribution of RP in septic and aseptic joint lesions has been developed.

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Korol, P., and M. Tkachenko. "DIAGNOSTIC ROLE OF BONE SCINTIGRAPHY IN EARLY PROGNOSIS OF PARAENDOPROSTHETIC COMPLICATIONS IN ARTHROPLASTY OF HIP AND KNIEE JOINTS." Likarska sprava, no. 7-8 (December 30, 2018): 73–78. http://dx.doi.org/10.31640/vd.7-8.2018(12).

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For 10 years, we studied the diagnostic role of three-phase bone scintigraphy (3-f BS) in the early prognosis of paraendoprosthetic complications in patients with degenerative-dystrophic and infectious-inflammatory diseases of the hip and knee joints. Using 3-f BS, the kinetic radionuclide parameters of inclusion and distribution of radiopharmaceutical (RP) in the projection of affected joints were evaluated. It was determined that the kinetics of osteotropic RP in the foci of fixation of affected joints in infectious and inflammatory processes is characterized by the predominance of retention and specific accumulation of the drug in the early and delayed static phase of 3-f BS in comparison with foci of fixing RP in degenerative-dystrophic lesions, which correlates with the differences destructively-reparative processes in them.According to the results of the analysis of the kinetic parameters, a radionuclide model of the dynamics of inclusion and distribution of RP in septic and aseptic joint lesions has been developed.

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Boangiu, Alexandra Doina, and Gabriela Mihailescu. "VISUAL DISTURBANCES – A BORDERLINE BETWEEN OPHTHALMOLOGY AND NEUROLOGY." Romanian Journal of Neurology 15, no. 4 (December 31, 2016): 149–54. http://dx.doi.org/10.37897/rjn.2016.4.1.

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Visual acuity loss can be due to eye ball diseases or to lesions of the optic nerves, visual pathway or cortical projection of vision. The differential diagnosis can be challenging and though patients go first to the ophthalmologist, there is not always the ophthalmologist who can diagnose and treat the patient. For a great number of causes/diseases, a neurologist should also see the patient, even if there is a transient or persistent monocular or binocular visual acuity loss a disturbance of the visual field or of the perception of colours. Visual acuity loss can be more than this. It can be a symptom or a sign of a neurological or systemic disease and a rapid diagnosis and specific treatment are mandatory in order to treat the symptoms and improve the patient’s quality of life.

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Hamassaki, Dânia E., and Luiz R. G. Britto. "Thalamic origin of neuropeptide Y innervation of the accessory optic nucleus of the pigeon (Columba livia)." Visual Neuroscience 5, no. 3 (September 1990): 249–59. http://dx.doi.org/10.1017/s0952523800000328.

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AbstractImmunohistochemical and tracing techniques were used in combination to reveal the source of a neuropeptide Y-like immunoreactive (NPY-LI) plexus in the nucleus of the basal optic root (nBOR) of the pigeon accessory optic system. Injections of rhodamine-labeled latex microspheres into nBOR produced retrograde labeling of a population of neurons interposed between the principal optic nucleus of the dorsolateral thalamus (equivalent to the mammalian dorsal lateral geniculate nucleus) and the ventral lateral geniculate nucleus. The retrogradely labeled neurons were distributed mainly in the immediate vicinity of the lateral, dorsal, and ventral aspects of the nucleus rotundus. Immunohistochemical methods revealed many NPY-containing somata within the same intergeniculate thalamic area. Double-labeling immunohistochemical and retrograde tracing experiments evidenced that many NPY-LI neurons in the intergeniculate area contained rhodamine microspheres that had been previously injected into the ipsilateral nBOR. The projection of that general thalamic area to the nBOR was then confirmed by means of anterograde transport of Phaseolus vulgaris leucoagglutinin. In these experiments, the intergeniculate region was demonstrated to project to all divisions of the nBOR and to every other retino-recipient structure, including the suprachiasmatic nucleus. Finally, electrolytic lesions of the intergeniculate area produced a dramatic reduction in the number of NPY-LI axons and terminals within the ipsilateral nBOR and also within other retino-recipient structures. These data indicate the existence of a thalamic NPY-LI projection to the pigeon nBOR of the accessory optic system. This chemically specific projection originates from the intergeniculate area, which was shown in this study to project to all other retino-recipient structures. Thus, NPY may have a role in the functional organization of the accessory optic system and also of the avian visual system as a whole.

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Sinden, John D., Helen Hodges, and Jeffrey A. Gray. "Neural transplantation and recovery of cognitive function." Behavioral and Brain Sciences 18, no. 1 (March 1995): 10–35. http://dx.doi.org/10.1017/s0140525x00037249.

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AbstractCognitive deficits were produced in rats by different methods of damaging the brain: chronic ingestion of alcohol, causing widespread damage to diffuse cholinergic and aminergic projection systems; lesions (by local injection of the excitotoxins, ibotenate, quisqualate, and AMPA) of the nuclei of origin of the forebrain cholinergic projection system (FCPS), which innervates the neocortex and hippocampal formation; transient cerebral ischaemia, producing focal damage especially in the CA1 pyramidal cells of the dorsal hippocampus; and lesions (by local injection of the neurotoxin, colchicine) of the granule cells of the dentate gyrus. Following chronic alcohol or lesions of the FCPS, transplants of cholinergically rich fetal brain tissue into the terminal areas (neocortex and/or hippocampus) restored performance almost to control levels, with a time course consistent with growth of the transplants and integration with host tissue; transplants of cholinergically poor fetal tissue (hippocampus) were without effect, as were transplants of cholinergically rich tissue into the region containing the nuclei of origin of the FCPS. Grafts of primary cells enriched in glia and cultured neuroblastoma cells into the terminal areas of the FCPS were equally effective, suggesting that there are multiple mechanisms by which neural transplants can restore cognitive function following diffuse cholinergic damage. In contrast, after ischaemia- or neurotoxin-induced damage to CA1 or dentate granule cells respectively, cholinergically rich fetal transplants into the damaged hippocampal formation were ineffective in restoring performance. After ischaemic damage, however, performance was restored by suspension grafts of CA1 cells but not by transplants containing CA3 pyramidal cells or granule cells; and after colchicine damage it was restored by solid grafts containing granule but not CA1 pyramidal cells. Furthermore, electrophysiological evidence has demonstrated functional, graft type-specific host-graft functional neuronal connectivity. Thus, restoration of cognitive function by neural transplants is possible after damage to either diffuse (cholinergic) or point-to-point (intrahippocampal) forebrain systems, but the transplant must be appropriate to the damage to be repaired. Because the different types of brain damage studied provide analogues of human alcoholic dementia, Alzheimer's disease, and heart attack, these results are encouraging with regard to the eventual application of neural transplant surgery to the treatment of cognitive deficits in humans.

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Тимофеева, Olga Timofeeva, Алимова, Elena Alimova, Шпрах, Vladimir Shprakh, Лаврик, Sergey Lavrik, Сабирова, and Rufina Sabirova. "USE OF TRANSCRANIAL MAGNETIC STIMULATION IN CHILDREN WITH CONSEQUENCES OF PERINATAL BRAIN LESIONS." Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук 1, no. 6 (December 20, 2016): 71–75. http://dx.doi.org/10.12737/23746.

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1249children of 5–10years (716boys, 533girls) with consequences of perinatal lesions of the CNS were examined, 230 of them were treated with the transcranial magnetic stimulation method (TMS). Selection of the TMS regimens was carried out taking into account the specific clinical neurophysiological features of the patients both as monotherapy, as well as a part of complex neurorehabilitation. For example, when intensifying of the synchronizing influences of tha-lamic structures and EEG signs of a delay of formation of electrical cortical rhythmicity, in children with developmental dysphasia and difficulties of school training, a high-pitched stimulation in the projection of the sensomotor and speech zones of a cerebral cortex was chosen; when intensifying of desynchronization influences of a reticular formation of a brainstem; at motor type of a developmental dysphasia and clinical signs of ADHD syndrome, a low-frequency regimen of stimulation of front-parietal and central areas of a cerebral cortex were chosen. Efficiency of therapy within 55–60% concerning indicators of the speech sphere and the psychological status is reached at sessions of TMS together with correctional occupations with auxiliary specialists of the rehabilitation center – speech pathologists and psychologists. Efficiency of monotherapy of TMS in children with retardation of psycho-speech development made 30–35%. Sufficient clinical performance and safety of the technique, a possibility of holding sessions of TMS against the background of course neuroprotective therapy at children with cerebral palsy is shown.

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Lowentritt, Benjamin H., and Michael S. Kipper. "Understanding and Improving 18F-Fluciclovine PET/CT Reports: A Guide for Physicians Treating Patients with Biochemical Recurrence of Prostate Cancer." Prostate Cancer 2020 (April 26, 2020): 1–11. http://dx.doi.org/10.1155/2020/1929565.

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The positron emission tomography (PET) tracer 18F-fluciclovine has seen increasing use to localize disease in men with biochemical recurrence of prostate cancer, i.e., elevated prostate-specific antigen (PSA) levels post-treatment. 18F-Fluciclovine PET/computed tomography (CT) imaging reports now play central roles in many physician-patient discussions. However, because no standardized grading system or templates yet exist for 18F-fluciclovine image assessment, reports vary in format, comprehensiveness, and terminology and may be challenging to fully understand. To better utilize these documents, referring physicians should be aware of six key features of 18F-fluciclovine PET/CT. First, 18F-fluciclovine is a radiolabeled synthetic amino acid targeting the amino acid transporters ASCT2 and LAT1, which are ubiquitous throughout the body, but overexpressed in prostate cancer. Second, 18F-fluciclovine image interpretation is predominantly visual/qualitative: radiotracer uptake in suspicious lesions is compared with uptake in bone marrow or blood pool. Location of 18F-fluciclovine-avid lesions relative to typical recurrence sites and findings elsewhere in the patient are considered when evaluating lesions’ probability of malignancy, as is visibility on maximum intensity projection images when assessing bone lesions. Third, 18F-fluciclovine PET/CT detection rates increase as PSA levels rise. Fourth, detection rates may differ among centers, possibly due to equipment and reader experience. Fifth, since no diagnostic test is 100% accurate, scan data should not be used in isolation. Lastly, 18F-fluciclovine PET/CT findings frequently induce changes in disease management plans. In the prospective multicenter LOCATE and FALCON studies, scans altered management plans in 59% (126/213) and 64% (66/104) of patients, respectively; 78% (98/126) and 65% (43/66) of changes, respectively, involved modality switches. Referring physicians and imagers should collaborate to improve scan reports. Referrers should clearly convey critical information, including prescan PSA levels, and open clinical questions. Imagers should produce reports that read like consultations, avoid leaving open questions, and if needed, provide thoughts on next diagnostic steps.

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Goehre, Felix, Behnam Rezai Jahromi, Juha Hernesniemi, Ahmed Elsharkawy, Riku Kivisaari, Mikael von und zu Fraunberg, Juha Jääskeläinen, Hanna Lehto, and Martin Lehecka. "Characteristics of Posterior Cerebral Artery Aneurysms." Neurosurgery 75, no. 2 (April 8, 2014): 134–44. http://dx.doi.org/10.1227/neu.0000000000000363.

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Abstract BACKGROUND: Posterior cerebral artery (PCA) aneurysms are rare lesions. Because of their low incidence, the individual or institutional experience is usually limited. OBJECTIVE: To identify specific anatomic features related to PCA aneurysms based on the analyses of pretreatment angiograms. METHODS: We performed a detailed angiographic study of 81 patients with a diagnosis of 93 PCA aneurysms. Fifty-three patients underwent computed tomography angiography, 49 underwent digital subtraction angiography, and 6 underwent magnetic resonance angiography. Between 1980 and 2012, a total of 120 patients with 136 PCA aneurysms and 11 352 patients with 16 444 intracranial aneurysms were treated at our institutions. RESULTS: There were 29 ruptured and 64 unruptured PCA aneurysms. The distribution of the aneurysms along the PCA segments was P1 (n = 39; 9 ruptured), P1/P2 junction (n = 25; 9 ruptured), P2 (n = 21; 5 ruptured), and P3 (n = 8; 6 ruptured). The median aneurysm size was 7 mm for the ruptured and 4 mm for the unruptured aneurysms. Saccular aneurysms (n = 69, 74%) had a typical projection for each location: P1 segment, upward (67%); P1/P2 junction, anterior/upward (80%); P2 segment, lateral (67%); and P3 segment, posterior (50%). Multiple aneurysms were seen in 43 patients. PCA aneurysms related to arteriovenous malformations were observed in 10 patients. CONCLUSION: PCA aneurysms are infrequent lesions, often associated with multiple aneurysms and arteriovenous malformations and are fusiform in shape. Most ruptured PCA aneurysms are smaller than 10 mm and usually distally located. At each PCA segment, saccular PCA aneurysms have a typical dome orientation.

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Li, Lei, Meng-Qi Zhang, Xiao Sun, Wen-Ying Liu, Zhi-Li Huang, and Yi-Qun Wang. "Role of Dorsomedial Hypothalamus GABAergic Neurons in Sleep–Wake States in Response to Changes in Ambient Temperature in Mice." International Journal of Molecular Sciences 23, no. 3 (January 23, 2022): 1270. http://dx.doi.org/10.3390/ijms23031270.

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Good sleep quality is essential for maintaining the body’s attention during wakefulness, which is easily affected by external factors such as an ambient temperature. However, the mechanism by which an ambient temperature influences sleep–wake behaviors remains unclear. The dorsomedial hypothalamus (DMH) has been reported to be involved in thermoregulation. It also receives projection from the preoptic area, which is an important region for sleep and energy homeostasis and the suprachiasmatic nucleus—a main control area of the clock rhythm. Therefore, we hypothesized that the DMH plays an important role in the regulation of sleep related to ambient temperatures. In this study, we found that cold exposure (24/20/16/12 °C) increased wakefulness and decreased non–rapid eye movement (NREM) sleep, while warm exposure (32/36/40/44 °C) increased NREM sleep and decreased wakefulness compared to 28 °C conditions in wild-type mice. Then, using non-specific and specific apoptosis, we found that lesions of whole DMH neurons and DMH γ–aminobutyric acid (GABA)-ergic neurons induced by caspase-3 virus aggravated the fluctuation of core body temperature after warm exposure and attenuated the change in sleep–wake behaviors during cold and warm exposure. However, chemogenetic activation or inhibition of DMH GABAergic neurons did not affect the sleep–wake cycle. Collectively, our findings reveal an essential role of DMH GABAergic neurons in the regulation of sleep–wake behaviors elicited by a change in ambient temperature.

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Mikhael, C. A., H. G. Abd El Aziz, and A. M. Ali. "Identification and characterisation of lumpy skin disease virus recently isolated from Giza, Egypt." BULGARIAN JOURNAL OF VETERINARY MEDICINE 26, no. 1 (2023): 53–64. http://dx.doi.org/10.15547/bjvm.2021-0008.

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Lumpy skin disease (LSD) is a viral disease, geographically distributed in Africa and now, vigorously spread in the Near East and also in Europe and Asia. It has a significant economic impact on cattle industry in Africa. The aim of this study was isolation and rapid identification of LSD virus circulating in Egypt from clinically suspected cattle based on clinical and molecular basis in a rapid and accurate way. Fifteen representative specimens (skin sitfasts) were collected in 2018 from clinically infected cattle in Giza governorate, Egypt. The virus was isolated on chorioallantoic membrane of specific pathogen free embryonated chicken eggs and Madin Darby Bovine Kidney tissue culture cells. The isolated virus was identified and confirmed by conventional polymerase chain reaction (PCR) and real-time PCR. Histopathological examination of the lesions showed a pathognomic intracytoplasmic inclusion body in dermal stroma section. The section of dermal layer revealed vasculitis with projection of its endothelial lining. It was concluded that LSD was enzootic in Egypt and still circulating among Egyptian cattle so that LSD virus could be isolated and identified by traditional and molecular diagnostic methodes. Real time PCR assay could be applied for rapid and accurate confirmation of the field isolate of LSD virus.

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Marciante, Alexandria B., Lei A. Wang, Joel T. Little, and J. Thomas Cunningham. "Caspase lesions of PVN-projecting MnPO neurons block the sustained component of CIH-induced hypertension in adult male rats." American Journal of Physiology-Heart and Circulatory Physiology 318, no. 1 (January 1, 2020): H34—H48. http://dx.doi.org/10.1152/ajpheart.00350.2019.

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Obstructive sleep apnea is characterized by interrupted breathing that leads to cardiovascular sequelae including chronic hypertension that can persist into the waking hours. Chronic intermittent hypoxia (CIH), which models the hypoxemia associated with sleep apnea, is sufficient to cause a sustained increase in blood pressure that involves the central nervous system. The median preoptic nucleus (MnPO) is an integrative forebrain region that contributes to blood pressure regulation and neurogenic hypertension. The MnPO projects to the paraventricular nucleus (PVN), a preautonomic region. We hypothesized that pathway-specific lesions of the projection from the MnPO to the PVN would attenuate the sustained component of chronic intermittent hypoxia-induced hypertension. Adult male Sprague-Dawley rats (250–300 g) were anesthetized with isoflurane and stereotaxically injected bilaterally in the PVN with a retrograde Cre-containing adeno-associated virus (AAV; AAV9.CMV.HI.eGFP-Cre.WPRE.SV40) and injected in the MnPO with caspase-3 (AAV5-flex-taCasp3-TEVp) or control virus (AAV5-hSyn-DIO-mCherry). Three weeks after the injections the rats were exposed to a 7-day intermittent hypoxia protocol. During chronic intermittent hypoxia, controls developed a diurnal hypertension that was blunted in rats with caspase lesions. Brain tissue processed for FosB immunohistochemistry showed decreased staining with caspase-induced lesions of MnPO and downstream autonomic-regulating nuclei. Chronic intermittent hypoxia significantly increased plasma levels of advanced oxidative protein products in controls, but this increase was blocked in caspase-lesioned rats. The results indicate that PVN-projecting MnPO neurons play a significant role in blood pressure regulation in the development of persistent chronic intermittent hypoxia hypertension. NEW & NOTEWORTHY Chronic intermittent hypoxia associated with obstructive sleep apnea increases oxidative stress and leads to chronic hypertension. Sustained hypertension may be mediated by angiotensin II-induced neural plasticity of excitatory median preoptic neurons in the forebrain that project to the paraventricular nucleus of the hypothalamus. Selective caspase lesions of these neurons interrupt the drive for sustained hypertension and cause a reduction in circulating oxidative protein products. This indicates that a functional connection between the forebrain and hypothalamus is necessary to drive diurnal hypertension associated with intermittent hypoxia. These results provide new information about central mechanisms that may contribute to neurogenic hypertension.

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Lupo, F. N., Paola Arnaboldi, L. Santoro, E. D'Anna, C. Beltrami, E. M. Mazzoleni, P. Veronesi, A. Maggioni, and F. Didier. "The effects of a multimodal training program on burnout syndrome in gynecologic oncology nurses and on the multidisciplinary psychosocial care of gynecologic cancer patients: An Italian experience." Palliative and Supportive Care 11, no. 3 (October 10, 2012): 199–203. http://dx.doi.org/10.1017/s1478951512000247.

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AbstractObjective:In cancer care, the burden of psycho-emotional elements involved on the patient–healthcare provider relationship cannot be ignored. The aim of this work is to have an impact on the level of burnout experienced by European Institute of Oncology (IEO) gynecologic oncology nurses (N = 14) and on quality of multidisciplinary team work.Method:We designed a 12 session multimodal training program consisting of a 1.5 hour theoretical lesson on a specific issue related to gynecologic cancer patient care, 20 minute projection of a short film, and 1.75 hours of role-playing exercises and experiential exchanges. The Link Burnout Questionnaire (Santinello, 2007) was administered before and after the completion of the intervention. We also monitored the number of patients referred to the Psycho-oncology Service as an indicator of the efficacy of the multidisciplinary approach.Results:After the completion of the program, the general level of burnout significantly diminished (p = 0.02); in particular, a significant decrease was observed in the “personal inefficacy” subscale (p = 0.01). The number of patients referred to the Psycho-oncology Service increased by 50%.Significance of results:Nurses are in the first line of those seeing patients through the entire course of the disease. For this reason, they are at a particularly high risk of developing work-related distress. Structured training programs can be a valid answer to work-related distress, and feeling part of a multidisciplinary team helps in providing patients with better psychosocial care.

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Oripov, O. I., and R. Z. Umarov. "Method for early visualization of COVID-19 associated cavernous sinus thrombosis." Modern technologies in ophtalmology, no. 2 (June 15, 2021): 190–92. http://dx.doi.org/10.25276/2312-4911-2021-2-190-192.

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Purpose. Development and evaluation of the effectiveness of the most optimal method of imaging for COVID-19 associated cavernous sinus thrombosis (CST). Material and methods. The study included the results of observation of 98 patients with CST. In all cases, COVID-19 confirmed by serological test results and the presence of specific lung lesions. The description and interpretation of MRI images in special modes (T2 TSE (cut 0.6-1.6 mm) and Dark fluid T2 (cut 0.6-1.6 mm), which allow determining the presence of a thrombus, have been carried out. Results. The use of this imaging module made it possible to determine the development of thrombosis in the projection of the orbital vein before its transition to the cavernous sinus in 24 patients who underwent COVID-19 and were admitted with complaints of difficulty in nasal breathing, purulent nasal discharge and severe headache. The detection of thrombus formation at this stage and the beginning of early intensive conservative therapy made it possible to achieve a favorable clinical outcome in the patient in the form of preserving the eyeball as an organ and partially preserving its functional capacity. In other cases, the sensitivity and specificity of the proposed technique were also high and amounted to more than 90%. Conclusion. The proposed imaging method for COVID-19 associated CST is highly sensitive and allows timely diagnosis and initiation of appropriate treatment, which will lead to a more favorable outcome in patients. Key words: cavernous sinus thrombosis; COVID-19; imaging; MRI.

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Calò, Karol, Giuseppe De Nisco, Diego Gallo, Claudio Chiastra, Ayla Hoogendoorn, David A. Steinman, Stefania Scarsoglio, Jolanda J. Wentzel, and Umberto Morbiducci. "Exploring wall shear stress spatiotemporal heterogeneity in coronary arteries combining correlation-based analysis and complex networks with computational hemodynamics." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 234, no. 11 (May 28, 2020): 1209–22. http://dx.doi.org/10.1177/0954411920923253.

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Atherosclerosis at the early stage in coronary arteries has been associated with low cycle-average wall shear stress magnitude. However, parallel to the identification of an established active role for low wall shear stress in the onset/progression of the atherosclerotic disease, a weak association between lesions localization and low/oscillatory wall shear stress has been observed. In the attempt to fully identify the wall shear stress phenotype triggering early atherosclerosis in coronary arteries, this exploratory study aims at enriching the characterization of wall shear stress emerging features combining correlation-based analysis and complex networks theory with computational hemodynamics. The final goal is the characterization of the spatiotemporal and topological heterogeneity of wall shear stress waveforms along the cardiac cycle. In detail, here time-histories of wall shear stress magnitude and wall shear stress projection along the main flow direction and orthogonal to it (a measure of wall shear stress multidirectionality) are analyzed in a representative dataset of 10 left anterior descending pig coronary artery computational hemodynamics models. Among the main findings, we report that the proposed analysis quantitatively demonstrates that the model-specific inlet flow-rate shapes wall shear stress time-histories. Moreover, it emerges that a combined effect of low wall shear stress magnitude and of the shape of the wall shear stress–based descriptors time-histories could trigger atherosclerosis at its earliest stage. The findings of this work suggest for new experiments to provide a clearer determination of the wall shear stress phenotype which is at the basis of the so-called arterial hemodynamic risk hypothesis in coronary arteries.

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Schultz, Wolfram. "Predictive Reward Signal of Dopamine Neurons." Journal of Neurophysiology 80, no. 1 (July 1, 1998): 1–27. http://dx.doi.org/10.1152/jn.1998.80.1.1.

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Schultz, Wolfram. Predictive reward signal of dopamine neurons. J. Neurophysiol. 80: 1–27, 1998. The effects of lesions, receptor blocking, electrical self-stimulation, and drugs of abuse suggest that midbrain dopamine systems are involved in processing reward information and learning approach behavior. Most dopamine neurons show phasic activations after primary liquid and food rewards and conditioned, reward-predicting visual and auditory stimuli. They show biphasic, activation-depression responses after stimuli that resemble reward-predicting stimuli or are novel or particularly salient. However, only few phasic activations follow aversive stimuli. Thus dopamine neurons label environmental stimuli with appetitive value, predict and detect rewards and signal alerting and motivating events. By failing to discriminate between different rewards, dopamine neurons appear to emit an alerting message about the surprising presence or absence of rewards. All responses to rewards and reward-predicting stimuli depend on event predictability. Dopamine neurons are activated by rewarding events that are better than predicted, remain uninfluenced by events that are as good as predicted, and are depressed by events that are worse than predicted. By signaling rewards according to a prediction error, dopamine responses have the formal characteristics of a teaching signal postulated by reinforcement learning theories. Dopamine responses transfer during learning from primary rewards to reward-predicting stimuli. This may contribute to neuronal mechanisms underlying the retrograde action of rewards, one of the main puzzles in reinforcement learning. The impulse response releases a short pulse of dopamine onto many dendrites, thus broadcasting a rather global reinforcement signal to postsynaptic neurons. This signal may improve approach behavior by providing advance reward information before the behavior occurs, and may contribute to learning by modifying synaptic transmission. The dopamine reward signal is supplemented by activity in neurons in striatum, frontal cortex, and amygdala, which process specific reward information but do not emit a global reward prediction error signal. A cooperation between the different reward signals may assure the use of specific rewards for selectively reinforcing behaviors. Among the other projection systems, noradrenaline neurons predominantly serve attentional mechanisms and nucleus basalis neurons code rewards heterogeneously. Cerebellar climbing fibers signal errors in motor performance or errors in the prediction of aversive events to cerebellar Purkinje cells. Most deficits following dopamine-depleting lesions are not easily explained by a defective reward signal but may reflect the absence of a general enabling function of tonic levels of extracellular dopamine. Thus dopamine systems may have two functions, the phasic transmission of reward information and the tonic enabling of postsynaptic neurons.

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Hennessy, Sara, and Rosemary Deaney. "“Intermediate Theory” Building: Integrating Multiple Teacher and Researcher Perspectives through In-Depth Video Analysis of Pedagogic Strategies." Teachers College Record: The Voice of Scholarship in Education 111, no. 7 (July 2009): 1753–95. http://dx.doi.org/10.1177/016146810911100701.

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Background/Context This work draws on a “participatory” approach to research collaboration that respects the teacher's “voice” in building on and extending the interactive “colearning” agreements between researchers and practitioners that work toward improving practice. Both parties in these agreements act as agents of (reflexive) inquiry, actively participating in rigorous and systematic joint analysis and contributing interpretative insights. Focus of Study This article describes and reflects on a collaborative approach to the analysis of digital video recordings of classroom activity. Our primary focus was assisting teachers to make explicit the pedagogical rationale underlying their practice. A key aim was to draw on sociocultural perspectives to develop a shared, grounded account of the processes through which teachers strategically mediate subject learning, in the context of using projection technology. The process of collaboration itself is our focus here. Participants Four UK teachers, one in each of four secondary subject areas (English, mathematics, science and history), and their students aged 12–15, took part in the research. The teachers were all experienced, reflective practitioners. The research collaboration also involved a colleague of each teacher, two researchers (the authors), and academic subject specialist colleagues. Research Design A case study design was used to collect qualitative observational data. Data Collection and Analysis Teachers were observed over six lessons each and interviewed four times. They also collaborated with us in critical scrutiny and discussion of lesson videos during a series of four recorded meetings, making underlying rationale explicit and identifying emerging themes. Student perspectives were sought through two focus group interviews in each case. Copies of student work and all lesson materials and outlines were collected, screen displays were captured, and each teacher kept a diary (unstructured) recording his or her planning, decision making, and/or postlesson reflections. Interview transcripts, individual commentary, meeting notes, and diaries were thematically analyzed using HyperResearch software. Findings The dialogic process culminated in development of “intermediate theory” bridging between teachers’ perspectives on supporting learning in specific settings, and key constructs from sociocultural theory. Hence, a priori theories were elaborated, integrated, and reframed using a common language. Conclusions/Recommendations The findings are being exploited through coconstruction and dissemination of a set of interactive CD-ROMs. These characterize the key themes and strategies emerging within and across cases, with illustrative video sequences for each case in turn hyperlinked to professional development activities and relevant aspects of the narrative accounts.

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Krynychnyh, H. I., S. M. Shuvalov, V. S. Pavlov, O. V. Kulytska, V. V. Nahaichuk, and M. L. Muntian. "DENSITOMETRIC METHOD FOR ASSESSING BONE TISSUE DENSITY IN ANTERIOR MAXILLA WITH PROGNOSTIC PURPOSE." Ukrainian Dental Almanac, no. 3 (September 26, 2023): 44–48. http://dx.doi.org/10.31718/2409-0255.3.2023.07.

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Density studies, or the densitometric method, are used in the maxillofacial area to monitor the treatment course and to improve or correct, when necessary, the treatment plan for the number of dento-facial diseases or conditions. Materials and methods. To identify potentially weaker areas of the maxillary bone, through which pathological processes, including cystic formations, may spread, the bone density in the anterior part of the maxilla was assessed in 100 patients. Results. The study has demonstrated that the bone density in three areas – between the central incisors, between the central and lateral incisors, between the lateral incisor and the canine – is lower when compared to the same measurements taken between the canine and the first premolar of the upper jaw. The analysis of measurements obtained from all subjects has revealed the area with the lowest bone density is found in the region between the central incisors in the upper jaw. In the subsequent phase of the study, for predictive purposes, the ratio of bone density measurements in these areas with lower bone density to the same measurements in the adjacent region (between the canine and the first premolar of the upper jaw) was established. The average values of the bone density comparison were as follows: between the central incisors and the adjacent region, it was 0.77±0.01; between the central and lateral incisors and the adjacent region, it was 0.93±0.01; and between the lateral incisor and the canine and the adjacent region, it was 0.85±0.01. Based on these calculations, different risk levels for the potential spread of pathological processes in the maxillary fissure regions were identified. Conclusions. Radiological density in the areas of projection of the maxillary fissures is lower compared to the density of adjacent bone tissue. This indirectly suggests the vulnerability of these areas and their potential contribution to the diffuse nature of lesions and the formation of specific cystic forms.

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Becker, D. L., and J. E. Cook. "Initial disorder and secondary retinotopic refinement of regenerating axons in the optic tract of the goldfish: signs of a new role for axon collateral loss." Development 101, no. 2 (October 1, 1987): 323–37. http://dx.doi.org/10.1242/dev.101.2.323.

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The optic tract of the goldfish splits into two brachia just before it reaches the tectum, normal optic axons being distributed systematically between the two according to their retinal origins. The orderliness of this division, like that of the retinotectal projection itself, is conventionally attributed to a system of specific axonal guidance cues. However, the brachial distribution of regenerated axons is much less orderly; and, since there is evidence that these axons have many collateral branches in the nerve and tract, the gross order that remains after regeneration could potentially arise secondarily, in parallel with refinement of the retinotectal map, by a preferential loss of collaterals from the inappropriate brachium. The brachial paths of normal axons, and axons regenerated after optic nerve cut for periods ranging from 19 days to 5 years, were therefore studied by anterograde labelling with horseradish peroxidase from discrete retinal lesions or retrograde labelling of ganglion cells from a cut brachium. From 19 to 28 days, regenerating axons showed little or no preference for their normal brachium. During this period (which includes the first week of tectal synaptogenesis) an average of 46á3% of cells retrogradely labelled from a cut medial brachium were in dorsal retina, compared with only 1á45% in normal fish. Some preference for the normal brachium was evident at 35 days and significant order had returned by 42–70 days, when the average proportion of labelled cells in dorsal retina had fallen to 25á4% though the average number in the whole retina was unchanged. Thus a brachial refinement had occurred in parallel with refinement of the retinotectal map. These results support the idea of a selective loss of axon collaterals from the inappropriate brachium, though they do not exclude the possibility of some concurrent gain in the appropriate one. We suggest that refinement may depend on a process we term ‘sibling rivalry’: competition between different collaterals of the same axon to form a critical number of stable tectal synapses, in which the most- normally-routed branches have the best chance of succeeding and surviving. Developing normal axons might also make use of collateral formation and ‘sibling rivalry’ to generate and refine the complex interwoven patterns of the normal optic tract.

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Williamson, K. "POS0778 METASTATIC ANGIOSARCOMA MASQUERADING AS SYSTEMIC INFLAMMATORY DISEASE WITH REFRACTORY PERICARDITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 680.1–681. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5235.

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BackgroundRheumatologists are frequently asked to evaluate patients with acute pericarditis. The majority of cases are idiopathic with systemic autoimmune disease underlying maybe 7% or less of cases in developed countries.[1-2]It is critical to recognize the presence of systemic symptoms or poor prognostic pericarditis features, such as tamponade physiology or poor response to non-steroidal anti-inflammatories, that raise concern for a malignant etiology of pericarditis.[1-2]ObjectivesA case report of a patient presenting with refractory pericarditis caused by metastatic angiosarcoma.MethodsA 46 year old male presented for evaluation of unresolving pericarditis. Five months prior, he had developed abrupt-onset pericarditic chest pain with associated dyspnea. Initial ED evaluation was notable for normal troponins and non-specific T wave abnormality on ECG. CT chest angiogram revealed a trace pericardial effusion and isolated right axillary lympadenopathy. The patient declined further evaluation. He presented a week later with persistent pericarditic pain. Echocardiogram showed enlargement of the pericardial effusion with possible early tamponade. Respiratory viral testing was negative. C-reactive protein (CRP) was elevated to 20.83mg/dL (Ref ≤0.5mg/dL) and ferritin to 2344.4ng/mL (Ref 21.8-274.7ng/mL). Soluble IL-2 receptor and blood counts were normal. Rheumatoid factor was weakly positive with ANA, anti-DNA, anti-CCP, and ANCA returning negative. Core needle biopsy of an axillary lymph node was negative for malignancy. Pericardiocentesis was deferred due to patient preference and stability. He was started on colchicine for autoimmune versus idiopathic pericarditis without significant improvement. He was transitioned to prednisone with improvement in his chest pain, effusion, and CRP; dyspnea and hyperferritinemia persisted. Attempts to taper prednisone failed due to flaring of pericarditis. The patient was referred to our center for evaluation of refractory pericarditis and possible systemic inflammatory disease. No signs or symptoms of RA or CTD were present. The patient endorsed recent night sweats, 11 kg of weight loss, and new bone pain. Full body PET/CT was pursued and demonstrated two FDG avid masses adjacent to the right side of the heart along with multiple lytic bone lesions of the spine and pelvis.Figure 1.(A) PET Maximum intensity projection showing large cardiac mass (red arrow) and multiple FDG avid bone lesions (yellow arrows). (B) PET Axial fused image showing large FDG avid cardiac mass.ResultsCardiac CT confirmed malignant-appearing, centrally necrotic mass along the right side of the heart extending to involve the pericardium. Iliac bone biopsy confirmed a diagnosis of metastatic angiosarcoma. He was not a candidate for cardiac tumor resection and was referred to oncology for palliative chemotherapy.ConclusionPrimary malignant cardiac tumors are a rare cause of pericarditis. Cardiac angiosarcomas are the most common type of primary malignant cardiac tumor. They most commonly arise from the right atrium or pericardium and may present with pericarditis-like symptoms.[3]References[1]Gouriet F, Levy PY, Casalta JP, Zandotti C, Collart F, Lepidi H, Cautela J, Bonnet JL, Thuny F, Habib G, Raoult D. Etiology of Pericarditis in a Prospective Cohort of 1162 Cases. Am J Med. 2015 Jul;128(7):784.e1-8. doi: 10.1016/j.amjmed.2015.01.040. Epub 2015 Mar 10. PMID: 25770033.[2]Imazio M, Cecchi E, Demichelis B, Ierna S, Demarie D, Ghisio A, Pomari F, Coda L, Belli R, Trinchero R. Indicators of poor prognosis of acute pericarditis. Circulation. 2007 May 29;115(21):2739-44. doi: 10.1161/CIRCULATIONAHA.106.662114. Epub 2007 May 14. PMID: 17502574.[3]Joseph AL, Wilklow FE, Olivier JJ, Joseph GJ, Glancy DL. Angiosarcoma of the Heart Presenting as Subacute Pericarditis. Am J Cardiol. 2017 Mar 15;119(6):941-943. doi: 10.1016/j.amjcard.2016.11.049. Epub 2016 Dec 18. PMID: 28043397.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

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Goryawala, Mohammed, Hung-Yu Henry Lee, Ling Tong, Trupti Patil, Alex Harwig, Chloe Xia, Suthara Ramachandran, et al. "Abstract 4151: Development of a cancer-activated biologic imaging platform for early lung cancer diagnosis." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4151. http://dx.doi.org/10.1158/1538-7445.am2024-4151.

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Abstract Current modalities, such as LDCT and fluorodeoxyglucose positron emission tomography (FDG PET), for early lung cancer imaging, rely upon proxies resulting in poor specificity and/or sensitivity. They are also unreliable for discriminating benign versus malignant lesions resulting in the requirement of longitudinal analyses euphemistically called “watchful waiting”. Lung biopsies are marred by significant false negative rates and pose complications of collapsed lungs or bleeding in up to 22% of procedures and death rates up to 1%. To overcome these obstacles, Earli is developing a non-invasive, highly specific cancer-activated imaging platform that usurps dysregulated gene expression within malignancies to force only cancer cells to produce a synthetic biomarker that can be localized using PET imaging. EARLI-204 is a lipid nanoparticle that contains a DNA nanoplasmid comprised of a cancer-activated promoter driving selective expression of a functionally inactivated somatostatin receptor 2 (SSTR2fi) gene. Abrogation of internalization and signal transduction allows the safe use of SSTR2fi as an ectopically expressed PET reporter gene (PRG). Following administration, EARLI-204 transfects tumor and normal cells but transcriptional activation only within cancer cells results in selective cell-surface expression of SSTR2fi that can be imaged with FDA-approved SSTR2 PET tracers. H1299 human lung cancer cells engineered to express SSTR2 (H1299-SSTR2) revealed a discernable PET signal with as little as 31,000 engineered cells. Mixed cell titration studies using subcutaneous (SQ) tumors with H1299-SSTR2 and non-expressing H1299-wt cells suggest tumors with between 0.1% and 1% H1299-SSTR2 cells had a significant PET signal, compared to tumors with 100% H1299-wt. This result sets a benchmark transfection of ~1% to achieve a PET signal. Intratumoral (IT) dose titration of EARLI-204 revealed that 5 ug of EARLI-204 generates a significant PET signal. Consistent with the H1299-SSTR2 studies, IHC shows ~1% of tumor cells express the PRG at a 5 ug IT dose level. Furthermore, we measured 70 copies of EARLI-204 DNA per cell resulting in 22,629 SSTR2 mRNA copies/25 ng at a 5 ug IT dose level. IV dosing of EARLI-204 in SQ and intralung tumor models results in cancer-activated expression of SSTR2fi in both SQ and small (<4 mm) lung tumors with significantly increased (p < 0.05) PET signal. For lung tumors, analyses showed 1 copy of EARLI-204 DNA/cell resulting in 780 SSTR2 mRNA copies/25 ng. The results demonstrate an effective molecular imaging platform for drug discovery ranging from in vivo screening to building PK-PD-efficacy relationships and enabling human dose projection for the Earli PET localization drug. The benchmarks and findings established with this preclinical imaging pipeline are currently being evaluated in large animals such as dogs and pigs, and will be translated to humans in planned clinical trials. Citation Format: Mohammed Goryawala, Hung-Yu Henry Lee, Ling Tong, Trupti Patil, Alex Harwig, Chloe Xia, Suthara Ramachandran, Dariusz Wodziak, Dean Felsher, Tim Sproul, David Suhy. Development of a cancer-activated biologic imaging platform for early lung cancer diagnosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4151.

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Saldeitis, Katja, Marcus Jeschke, Eike Budinger, Frank W. Ohl, and Max F. K. Happel. "Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing." Frontiers in Neural Circuits 15 (July 12, 2021). http://dx.doi.org/10.3389/fncir.2021.659280.

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Corticofugal projections outnumber subcortical input projections by far. However, the specific role for signal processing of corticofugal feedback is still less well understood in comparisonto the feedforward projection. Here, we lesioned corticothalamic (CT) neurons in layers V and/or VI of the auditory cortex of Mongolian gerbils by laser-induced photolysis to investigate their contribution to cortical activation patterns. We have used laminar current-source density (CSD) recordings of tone-evoked responses and could show that, particularly, lesion of CT neurons in layer VI affected cortical frequency processing. Specifically, we found a decreased gain of best-frequency input in thalamocortical (TC)-recipient input layers that correlated with the relative lesion of layer VI neurons, but not layer V neurons. Using cortical silencing with the GABAa-agonist muscimol and layer-specific intracortical microstimulation (ICMS), we found that direct activation of infragranular layers recruited a local recurrent cortico-thalamo-cortical loop of synaptic input. This recurrent feedback was also only interrupted when lesioning layer VI neurons, but not cells in layer V. Our study thereby shows distinct roles of these two types of CT neurons suggesting a particular impact of CT feedback from layer VI to affect the local feedforward frequency processing in auditory cortex.

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Nath, Moushumi, Sanjeev K. Bhardwaj, Lalit K. Srivastava, and Tak Pan Wong. "Altered excitatory and decreased inhibitory transmission in the prefrontal cortex of male mice with early developmental disruption to the ventral hippocampus." Cerebral Cortex, March 17, 2022. http://dx.doi.org/10.1093/cercor/bhac107.

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Abstract Ventral hippocampal (vHPC)-prefrontal cortical (PFC) pathway dysfunction is a core neuroimaging feature of schizophrenia. However, mechanisms underlying impaired connectivity within this pathway remain poorly understood. The vHPC has direct projections to the PFC that help shape its maturation. Here, we wanted to investigate the effects of early developmental vHPC perturbations on long-term functional PFC organization. Using whole-cell recordings to assess PFC cellular activity in transgenic male mouse lines, we show early developmental disconnection of vHPC inputs, by excitotoxic lesion or cell-specific ablations, impairs pyramidal cell firing output and produces a persistent increase in excitatory and decrease in inhibitory synaptic inputs onto pyramidal cells. We show this effect is specific to excitatory vHPC projection cell ablation. We further identify PV-interneurons as a source of deficit in inhibitory transmission. We find PV-interneurons are reduced in density, show a reduced ability to sustain high-frequency firing, and show deficits in excitatory inputs that emerge over time. We additionally show differences in vulnerabilities to early developmental vHPC disconnection, wherein PFC PV-interneurons but not pyramidal cells show deficits in NMDA receptor–mediated current. Our results highlight mechanisms by which the PFC adapts to early developmental vHPC perturbations, providing insights into schizophrenia circuit pathology.

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Cha, Seungwoo, ByeongChang Jeong, Myungwon Choi, Sohyun Kwon, Stephanie Hyeyoung Lee, Nam-Jong Paik, Won-Seok Kim, and Cheol E. Han. "White matter tracts involved in subcortical unilateral spatial neglect in subacute stroke." Frontiers in Neurology 13 (September 30, 2022). http://dx.doi.org/10.3389/fneur.2022.992107.

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BackgroundUnilateral spatial neglect (USN) is common and associated with poor motor and cognitive outcomes as well as impaired quality of life following stroke. Traditionally, the neural substrates underlying USN have been thought to be cortical areas, such as the posterior parietal cortex. However, patients with stroke involving only subcortical structures may also present with USN. While only a few studies have reported on USN in subcortical stroke, the involvement of white matter tracts related to brain networks of visuospatial attention is one possible explanation for subcortical neglect. Therefore, this study aimed to investigate which specific white matter tracts are neural substrates for USN in patients with subcortical stroke.MethodsTwenty-two patients with subcortical stroke without cortical involvement who were admitted to the Department of Rehabilitation Medicine at Seoul National University Bundang Hospital were retrospectively enrolled. Nine subjects were subclassified into a “USN(+)” group, as they had at least two positive results on three tests (the Schenkenberg line bisection test, Albert's test, and house drawing test) and a score of 1 or higher on the Catherine Bergego scale. The remaining 13 subjects without abnormalities on those tests were subclassified into the “USN(–)” group. Stroke lesions on MRI were manually drawn using MRIcron software. Lesion overlapping and atlas-based analyses of MRI images were conducted. The correlation was analyzed between the overlapped lesion volumes with white matter tracts and the severity of USN (in the Albert test and the Catherine Bergego scale).ResultsLesions were more widespread in the USN(+) group than in the USN(–) group, although their locations in the right hemisphere were similar. The atlas-based analyses identified that the right cingulum in the cingulate cortex, the temporal projection of the superior longitudinal fasciculus, and the forceps minor significantly overlapped with the lesions in the USN(+) group than in the USN(–) group. The score of the Catherine Bergego scale correlated with the volume of the involved white matter tracts.ConclusionIn this study, white matter tracts associated with USN were identified in patients with subcortical stroke without any cortical involvement. Our study results, along with previous findings on subcortical USN, support that USN may result from damage to white matter pathways.

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Larivière, Sara, Bo-yong Park, Jessica Royer, Jordan DeKraker, Alexander Ngo, Ella Sahlas, Judy Chen, et al. "Connectome reorganization associated with temporal lobe pathology and its surgical resection." Brain, May 3, 2024. http://dx.doi.org/10.1093/brain/awae141.

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Abstract Network neuroscience offers a unique framework to understand the organizational principles of the human brain. Despite recent progress, our understanding of how the brain is modulated by focal lesions remains incomplete. Resection of the temporal lobe is the most effective treatment to control seizures in pharmaco-resistant temporal lobe epilepsy (TLE), making this syndrome a powerful model to study lesional effects on network organization in young and middle-aged adults. Here, we assessed the downstream consequences of a focal lesion and its surgical resection on the brain’s structural connectome, and explored how this reorganization relates to clinical variables at the individual patient level. We included adults with pharmaco-resistant TLE (n = 37) who underwent anterior temporal lobectomy between two imaging time points, as well as age- and sex-matched healthy controls who underwent comparable imaging (n = 31). Core to our analysis was the projection of high-dimensional structural connectome data—derived from diffusion MRI tractography from each subject—into lower-dimensional gradients. We then compared connectome gradients in patients relative to controls before surgery, tracked surgically-induced connectome reconfiguration from pre- to postoperative time points, and examined associations to patient-specific clinical and imaging phenotypes. Before surgery, individuals with TLE presented with marked connectome changes in bilateral temporo-parietal regions, reflecting an increased segregation of the ipsilateral anterior temporal lobe from the rest of the brain. Surgery-induced connectome reorganization was localized to this temporo-parietal subnetwork, but primarily involved postoperative integration of contralateral regions with the rest of the brain. Using a partial least-squares analysis, we uncovered a latent clinical-imaging signature underlying this pre- to postoperative connectome reorganization, showing that patients who displayed postoperative integration in bilateral fronto-occipital cortices also had greater preoperative ipsilateral hippocampal atrophy, lower seizure frequency, and secondarily generalized seizures. Our results bridge the effects of focal brain lesions and their surgical resections with large-scale network reorganization and inter-individual clinical variability, thus offering new avenues to examine the fundamental malleability of the human brain.

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Arndt, Clemens, Felix Güttler, Andreas Heinrich, Florian Bürckenmeyer, Ioannis Diamantis, and Ulf Teichgräber. "Deep Learning CT Image Reconstruction in Clinical Practice." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, December 10, 2020. http://dx.doi.org/10.1055/a-1248-2556.

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Background Computed tomography (CT) is a central modality in modern radiology contributing to diagnostic medicine in almost every medical subspecialty, but particularly in emergency services. To solve the inverse problem of reconstructing anatomical slice images from the raw output the scanner measures, several methods have been developed, with filtered back projection (FBP) and iterative reconstruction (IR) subsequently providing criterion standards. Currently there are new approaches to reconstruction in the field of artificial intelligence utilizing the upcoming possibilities of machine learning (ML), or more specifically, deep learning (DL). Method This review covers the principles of present CT image reconstruction as well as the basic concepts of DL and its implementation in reconstruction. Subsequently commercially available algorithms and current limitations are being discussed. Results and Conclusion DL is an ML method that utilizes a trained artificial neural network to solve specific problems. Currently two vendors are providing DL image reconstruction algorithms for the clinical routine. For these algorithms, a decrease in image noise and an increase in overall image quality that could potentially facilitate the diagnostic confidence in lesion conspicuity or may translate to dose reduction for given clinical tasks have been shown. One study showed equal diagnostic accuracy in the detection of coronary artery stenosis for DL reconstructed images compared to IR at higher image quality levels. Consequently, a lot more research is necessary and should aim at diagnostic superiority in the clinical context covering a broadness of pathologies to demonstrate the reliability of such DL approaches. Key Points: Citation Format

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Bergden, Jessica, and Maureen Estevez Stabio. "Development of a 3D Interactive Model for Teaching Intercortical Connectivity of Cerebral White Matter Tracts." FASEB Journal 30, S1 (April 2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.568.19.

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White matter tracts connect areas of the brain, spinal cord and body much like a highway system. In the past, the only way to visualize these white matter tracts was through cadaveric dissection of deep brain structures. Unfortunately these dissections, although extremely valuable for students, are challenging and time‐consuming, which limits their incorporation into the modern medical curriculum. With the advent of new imaging technologies, such as diffusion tensor imaging (DTI), it is possible to visualize this intricate cerebral superhighway in a living human brain. Through a process called tractography, the directional information within DTI datasets can be used to create 3D maps of fiber systems, their Cartesian directionality, and their connectivity patterns. A thorough understanding of intercortical networks is vital to interpret anatomical disconnections that occur when lesions intersect white matter tracts as seen in patients with neuropathologies such as stroke, multiple sclerosis and vascular dementias. Tractography not only has revolutionized diagnostic imaging, it also has enormous potential in the medical neuroscience classroom to help students visualize cerebral white matter networks. The goal of this project was to create an interactive tractography model of curvilinear cerebral white matter tracts, such as the fornix, corpus callosum and uncinate fasciculus, for use in medical and graduate neuroanatomy education. First, a de‐identified 3T diffusion‐weighted imaging (the raw form of DTI) dataset of a living, healthy adult subject was obtained. 3D Slicer was used to estimate the position and direction of fiber tracts and to generate a preliminary tractography model based on fractional anisotropy values. Then, the preliminary model was imported into Maya where it was virtually dissected into multiple objects, representing specific tracts, which can be manipulated individually. The user can zoom and rotate the model and as well as scroll over to select individual tracts at a time. The model can also be exported into web‐compatible HTML5 versions for use in online educational modules that include overlays, labels, and diagrammatic elements. In summary, this model allows students to (1) visualize major association, commissural, and projection white matter tracts in 3D; (2) independently explore the relationships of each tract to one another and to its global position within the brain; and (3) recognize intercortical connectivity patterns which underlie clinical loss of function in patients. This project fills a gap in medical neuroanatomy education where students often struggle to learn 3D cerebral architecture and lack opportunities to appreciate the myriad subcortical fiber systems. We are currently developing a supplemental case‐studies curriculum to link the clinical effects of various white matter lesions with the tracts illustrated in the 3D model. We anticipate that these case‐based hypothetical lesion scenarios will engage the learner by directly correlating patient care with 3D neuroanatomy. Future direction for this work will be to evaluate the efficacy of tractography models in the classroom for teaching intercortical connectivity of cerebral white matter tracts.

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Stobbe, Robert, Annie Boyd, Penelope Smyth, Derek Emery, Diana Valdés Cabrera, and Christian Beaulieu. "Sodium Intensity Changes Differ Between Relaxation- and Density-Weighted MRI in Multiple Sclerosis." Frontiers in Neurology 12 (July 14, 2021). http://dx.doi.org/10.3389/fneur.2021.693447.

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Introduction: The source of Tissue Sodium Concentration (TSC) increase in Multiple Sclerosis (MS) remains unclear, and could be attributed to altered intracellular sodium concentration or tissue microstructure. This paper investigates sodium in MS using three new MRI sequences.Methods: Three sodium scans were acquired at 4.7 T from 30 patients (11 relapsing-remitting, 10 secondary-progressive, 9 primary-progressive) and 9 healthy controls including: Density-Weighted (NaDW), with very short 30° excitation for more accurate TSC measurement; Projection Acquisition with Coherent MAgNetization (NaPACMAN), designed for enhanced relaxation-based contrast; and Soft Inversion Recovery FLuid Attenuation (NaSIRFLA), developed to reduce fluid space contribution. Signal was measured in both lesions (n = 397) and normal appearing white matter (NAWM) relative to controls in the splenium of corpus callosum and the anterior and posterior limbs of internal capsule. Correlations with clinical and cognitive evaluations were tested over all MS patients.Results: Sodium intensity in MS lesions was elevated over control WM by a greater amount for NaPACMAN (75%) than NaDW (35%), the latter representing TSC. In contrast, NaSIRFLA exhibited lower intensity, but only for region specific analysis in the SCC (−7%). Sodium intensity in average MS NAWM was not significantly different than control WM for either of the three scans. NaSIRFLA in the average NAWM and specifically the posterior limb of internal capsules positively correlated with the Paced Auditory Serial Addition Test (PASAT).Discussion: Lower NaSIRFLA signal in lesions and ~2× greater NaPACMAN signal elevation over control WM than NaDW can be explained with a demyelination model that also includes edema. A NAWM demyelination model that includes tissue atrophy suggests no signal change for NaSIRFLA, and only slightly greater NAWM signal than control WM for both NaDW and NaPACMAN, reflecting experimental results. Models were derived from previous total and myelin water fraction study in MS with T2-relaxometry, and for the first time include sodium within the myelin water space. Reduced auditory processing association with lower signal on NaSIRFLA cannot be explained by greater demyelination and its modeled impact on the three sodium MRI sequences. Alternative explanations include intra- or extracellular sodium concentration change. Relaxation-weighted sodium MRI in combination with sodium-density MRI may help elucidate microstructural and metabolic changes in MS.

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Liu, Yang, Yen-ting Chen, Chuan Zhang, Ping Zhou, Sheng Li, and Yingchun Zhang. "Motor unit distribution and recruitment in spastic and non-spastic bilateral biceps brachii muscles of chronic stroke survivors." Journal of Neural Engineering, August 4, 2022. http://dx.doi.org/10.1088/1741-2552/ac86f4.

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Abstract Objective- This study aims to characterize the motor units distribution and recruitment pattern in the spastic and non-spastic bilateral biceps brachii muscles (BBMs) of chronic stroke survivors. Approach- High-density surface electromyography (HD-sEMG) signals were collected from both spastic and non-spastic BBMs of fourteen chronic stroke subjects during isometric elbow flexion at 10%, 30%, 50% and 100% maximal voluntary contractions (MVCs). By combining HD-sEMG decomposition and bioelectrical source imaging, motor unit innervation zones (MUIZs) of the decomposed motor units were first localized in the 3D space of spastic and non-spastic BBMs. The motor unit depth defined as the distance between the localized MUIZ and its normal projection on the skin surface was then normalized to the arm radius of each subject and averaged at given contraction level. The averaged MU depth at different contraction levels on a specific arm side (intra-side) and the bilateral depths under a specific contraction level (inter-side) were compared. Main Results- The average depth of decomposed MUs increased with the contraction force and significant differences observed between 10% vs 50% (p < 0.0001), 10% vs 100% (p < 0.0001) and 30% vs 100% MVC (p = 0.0017) on the non-spastic side, indicating that larger MUs with higher recruitment threshold locate in deeper muscle regions. In contrast, no force-related difference in MU depth was observed on the spastic side, suggesting a disruption of orderly recruitment of MUs with increase of force level, or the MU denervation and the subsequent collateral reinnervation secondary to upper motor neuron lesions. Inter-side comparison demonstrated significant MU depth difference at 10% (p=0.0048) and 100% force effort (p=0.0026). Significance-This study represents the first effort to non-invasively characterize the MU distribution inside spastic and non-spastic bilateral BBM of chronic stroke patients by combining HD-sEMG recording, EMG signal decomposition and bioelectrical source imaging. The findings of this study advances our understanding regarding the neurophysiology of human muscles and the neuromuscular alterations following stroke. It may also offer important MU depth information for botulinum toxin (BoNT) injection in clinical post-stroke spasticity management.

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Tsarenko, Oleksandr, and Lina Novosad. "METHODOLOGICAL FEATURES OF USING IT TOOLS FOR SOFTWARE VISUALIZATION IN TECHNOLOGY LESSONS." Academic Notes Series Pedagogical Science 1, no. 208 (April 2023). http://dx.doi.org/10.36550/2415-7988-2023-1-208-255-259.

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The article is devoted to the identification of methodological features of the use of information and technical means of the new generation for the formation of key and subject competencies of students based on the visualization of the educational material of the school subject "Technology". Currently, visualization is interpreted as an active process of transformation of certain information (in our case – educational) into a visual image, which causes the need for its construction. At the same time, the concept of visualization involves the process of creating a visual image at a time when the generally recognized term "visibility" is already associated with a ready (formed) image of the research object. Accordingly, the concept of visualization of educational information (program material) goes beyond the boundaries defined by the usual term "visibility". Such an effective didactic tool as visualization should be used by the teacher only under the condition of pedagogical expediency outlined by the goals and objectives of a specific lesson, taking into account the existing material and technical base of the educational institution and educational and methodological support. The work investigated that visualization is quite often considered by teachers as a factor that ensures the memorization of educational material due to the activation of cognitive activity of pupils and performs an illustrative function. However, the information saturation of the modern world requires careful planning to determine the amount of visual and verbal information, as well as proper methodical training of the teacher with mandatory restructuring of the program material. Visualization of educational content is not a simple illustrative material, but a complete system of transmitting visual information, which should respond to the specific actions of the subject of the educational process and provide an opportunity to manage the information provided to the student through the projection screen or by other means. The content of the terms "visualization" and "visibility" has been clarified. Attention is focused on the fact that visualization ensures the intensification of the educational process, which is achieved due to the consolidation of the program material, which helps to significantly reduce the time for verbal reasoning and conclusions of high school students.

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Johnson-Glenberg, Mina C., Christine S. P. Yu, Frank Liu, Charles Amador, Yueming Bao, Shufan Yu, and Robert LiKamWa. "Embodied mixed reality with passive haptics in STEM education: randomized control study with chemistry titration." Frontiers in Virtual Reality 4 (July 14, 2023). http://dx.doi.org/10.3389/frvir.2023.1047833.

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Researchers, educators, and multimedia designers need to better understand how mixing physical tangible objects with virtual experiences affects learning and science identity. In this novel study, a 3D-printed tangible that is an accurate facsimile of the sort of expensive glassware that chemists use in real laboratories is tethered to a laptop with a digitized lesson. Interactive educational content is increasingly being placed online, it is important to understand the educational boundary conditions associated with passive haptics and 3D-printed manipulables. Cost-effective printed objects would be particularly welcome in rural and low Socio-Economic (SES) classrooms. A Mixed Reality (MR) experience was created that used a physical 3D-printed haptic burette to control a computer-based chemistry titration experiment. This randomized control trial study with 136 college students had two conditions: 1) low-embodied control (using keyboard arrows), and 2) high-embodied experimental (physically turning a valve/stopcock on the 3D-printed burette). Although both groups displayed similar significant gains on the declarative knowledge test, deeper analyses revealed nuanced Aptitude by Treatment Interactions (ATIs). These interactions favored the high-embodied experimental group that used the MR device for both titration-specific posttest knowledge questions and for science efficacy and science identity. Those students with higher prior science knowledge displayed higher titration knowledge scores after using the experimental 3D-printed haptic device. A multi-modal linguistic and gesture analysis revealed that during recall the experimental participants used the stopcock-turning gesture significantly more often, and their recalls created a significantly different Epistemic Network Analysis (ENA). ENA is a type of 2D projection of the recall data, stronger connections were seen in the high embodied group mainly centering on the key hand-turning gesture. Instructors and designers should consider the multi-modal and multi-dimensional nature of the user interface, and how the addition of another sensory-based learning signal (haptics) might differentially affect lower prior knowledge students. One hypothesis is that haptically manipulating novel devices during learning may create more cognitive load. For low prior knowledge students, it may be advantageous for them to begin learning content on a more ubiquitous interface (e.g., keyboard) before moving them to more novel, multi-modal MR devices/interfaces.

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Deiss, Yannick R., Safak Korkut, Terry Inglese, and Emanuele Laurenzi. "305 Augmented reality supported medication adherence for patients with atopic dermatitis and psoriasis." British Journal of Dermatology 188, Supplement_2 (January 25, 2023). http://dx.doi.org/10.1093/bjd/ljac140.006.

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Abstract Augmented reality (AR) is a technology that enables digital information layers, such as text, image, video and audio, to be positioned in the real environment seamlessly as holograms. The holograms are displayed through a smartphone camera view. AR-specific computer vision algorithms remodel the hologram’s position based on the device’s movement in real-time and create a mediated illusion of projection in reality. As dermatologic diagnosis primarily relies on visual perception, integrating AR can provide novel benefits for patients and doctors. Medication adherence challenges for patients with inflammatory skin diseases, specifically atopic dermatitis (AD) and psoriasis, are many and complex. Nearly one-third of patients with AD do not adhere to the therapy for their lesions. Factors such as lack of understanding, patients’ forgetfulness and dissatisfaction with the healing progress or the complementary therapy are the prominent influencers which lead to treatment interruption. The benefits of AR as an enabler of positive learning experiences have been addressed in various research in healthcare, with a strong focus on medical students. However, in-depth studies have yet to be conducted regarding the impact and opportunities for patients. Our project explores how AR can increase patients’ understanding of the inflammatory skin diseases AD and psoriasis. Since AR can visualize complex information, such as different stages of the treatment, AD patients have opportunities to overcome inadequate treatment compliance without any restrictions of mobility or location due to the nature of AR experiences. The project identifies the factors for integrating a mobile AR application into patients’ daily lives to increase their medication adherence. The characteristics of AR experiences and the existing studies and research results on AR in dermatology underline the value of creating interactive experiences compared to static images or printed information. Subsequently, an AR prototype is developed to investigate and evaluate the concept of AR in therapy understanding and medication adherence. The prototype allows patients to project the different stages of development of inflammatory skin diseases onto their skin as holograms and thus visualize the onset of treatment. The prototype was demonstrated to two dermatologists and four patients. They were asked to test the prototype and were surveyed using a semi-structured interview. AR was reported beneficial in increasing patients’ understanding of their disease and the motivation to adhere to the prescribed therapy. Moreover, AR visualizations of different developments of the affected skin were acknowledged as helpful. Within the analysis framework, the dermatologists and patients described many needs to ensure integration into everyday life. One of the core challenges reported is that the AR visualizations must be adapted to the patient’s skin type as realistically as possible. Henceforth, the interviewed dermatologists and patients critically evaluated that integrating such an application into patients’ daily life requires that the functions and content are valuable at every stage, explicitly mentioning a digital medication plan. A critical success factor is identified as communication between dermatologists and patients. Analysis suggests that an auxiliary function that facilitates sharing images of lesions for initial diagnosis has been specified as helpful by both stakeholder groups. In addition, these images document the course of the disease, which not only has a positive effect on the overall treatment but also helps to document changes in the course of the therapy. As an outlook, we integrate Artificial Intelligence (AI) techniques for patients to receive customized support in medication adherence and well-being-related content. AI will enable building a knowledge base about AD and psoriasis, reinforced with AR-supported visual feedback on treatment and references of individual adherence patterns.

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"PhD Project: Predictive and Functional Evaluation of Patients Derived Tumor Spheroids and Organoids-Investigating the Relationship between Size and Testing Performance." Journal of Pharmaceutical Research 8, no. 2 (July 18, 2023). http://dx.doi.org/10.33140/jpr.08.02.08.

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Pancreatic Cancer has proven to be one of the most severe forms of cancer with the worst anticipated prognosis. Mortality due to pancreatic cancer is expected to surpass that of breast and colorectal cancer combined by 2030 due to several reasons including aging, advanced stage when pancreatic cancer is detected in patients, lack of effective treatment strategy particularly in Pancreatic Ductal Adeno Carcinoma PDAC cases [01]. PDAC contributes to more than 7 % of cancer associated deaths world-wide with an overall survival rate 8.5% for 6-11 months only in patients with advanced stages of the Disease [02]. Pathological, genomic and clinical studies on PDAC patients have shown three different progressive forms of the disease Pancreatic Intraepithelial Neoplasia PanINs, Intraductal Mucinous Papillary Neoplas IPMN and Pancreatic Mucinous Cystic Neoplasm MCN which all express different stages of epithelial dysplasia, lobulocentric atrophy and ductal metaplasia [03]. Treatment options for PDAC sounds to be very limited and mostly include combined chemotherapy with gemcitabine/ nab paclitaxel together with surgical interference. Activation of KRAS oncogene via single point mutation in codon 12, inactivation of tumor suppressor genes CDKN2A, TP53, SMAD4 and R1 and RII receptors of TGF-B and activation of certain signaling pathways that include NFKB, STAT3 and SRC were found to be characteristic for PanINs and its progression to PDAC [04, 05]. Patient-derived xenografts PDXs have been validated as an effective tool to study PDAC but it required large amount of tissues and longer time to generate [06, 07]. However, Genetically Engineered Mouse Models GEMMs were found to be more precisely recapitulating the patho-physiological features of human PDA across different stages of the disease progression [08]. Previous studies have shown that both human PDA and GEMMs share common histological features including extensive stromal structure, diminished vasculature infiltration and less neoplastic cellularity content. This makes PDA patients-derived organoids and spheroids more difficult to culture as limited amount of epithelium-derived cancer cells are available to isolate. While 2D culture conditions couldn't support the growth of normal or untransformed non-neoplastic pancreatic cells, 3D culture was found to support both normal and transformed cells but otherwise allowed minimal propagation [09]. In this research, we isolate and culture 3D organoids from normal and malignant murine pancreatic tissues from wild type mice(n=10) and PDA GEMMS (n=20) respectively in order to study and model PDA Pathogenesis in Murine Model. Previous studies have shown success rate of around 70-73%. At the same time, Organoids are also planned to be established from non-PDAC tumors e.g. Pancreatic Acinar Cell Carcinoma and Distal Cholangiocarcinoma as the organoleptic and histopathological features of the lesions may indicate. In addition, some tissue samples are taken from the adjacent normal epithelial layers to the site of tumor in order to allow comparison between normal and cancer tissue cells from the same mouse. Likewise, 3D organoids are planned to be developed from normal (n=10) and malignant human pancreatic tissues (n=40) either sampled during surgical resection or from endoscopic biopsy samples. Then, orthotopic transplantation of the well-established murine and human PDA organoids will be made in wild mice C57BL/6J in order to assess how pathological lesions reminiscent of Pancreatic Intra-epithelial Neoplasia PanINs can be progressed into varying degrees of invasive PDA and may further develop into metastatic carcinomas in other organs e.g. liver, diaphragm, kidney and peritoneum. After modeling PDA pathogenesis using patient-derived organoid models in both murine and human, characteristic molecular genes signature in each isolated and in-vitro cultured organoid derived from both models will be further char-acterized using Whole Genome Sequencing of over 2000 PDA associated genes [03]. This will be further correlating to the whole transcriptomic analysis and comparative genes expression profiling using bulk RNA seq and q-RT PCR in addition to high-throughput proteomics using Immune-blotting and Immune- histochemistry IHC approaches. This can help investigate whether patients-derived organoids may function as an optimal model that recapitulates the characteristics of pancreatic malignancy when comparing histopathological lesions to the corresponding multi-omics data sets of PDAs in human and murine models. Personalized cancer treatment has proven to be the most effective method as judged by clinicians as some targeted therapies were found to be suitable for only subsets of patients than others who may develop less sensitivity to higher degrees of resistance to the same therapy [03]. In order to investigate how pancreatic organoids may assist clinicians finding the most appropriate target therapy, the isolated 50 PDO organoids including at least 10 organoids derived from normal issues and 40 organoids from tumor tissues will be exposed to a number of candidate anti-cancer compounds belonging to 10 categories of chemotherapy which vary according to their mechanism of action. In order to assess the response of PDA organoids to these drugs, two methods including The Cell Viability Assay developed by Promega Bio Sciences and The Electric Impedance Measurement developed by the Heinz-Nixdorf Lehrustul for Biomedical Electronics at The Technical University of Munich will be comparatively assessed [10-12]. The result will be finally compared to the corresponding patients' clinical data and actual patients' response to medical treatment as suggested by the physician. Resistance to the most commercially available anti-cancer drugs has been frequently noted by clinicians and it constitutes an actual hurdle towards proceeding with an effective treatment strategy despite being precisely personalized [13]. In order to assess how heterogeneous cells in the patients-derived PDOs may respond differently to anticancer drug compounds, we are going to assess the earliest Drug Tolerant Persisters ( DT) and the Extended Drug Tolerant Persisters (EDT) cells isolated from the Murine and Human PDOs before and after exposure to some selected anti-cancer therapeutics using Single Cell RNA- seq called Drop-seq and then we are going to analyze the obtained data using a bioinformatics platform called Uniform Manifold Approximation and Projection (UMAP) Dimensionality Reduction for further characterizing and clustering persistent cells against different increasing drug concentrations over time. Furthermore, previous studies have shown that resistance mechanisms of PDAC to anti- cancer therapeutics could be more likely associated with the role of epigenetic dysregulation of apoptotic pathways being one of the intrinsic tumor factors rather than being associated with the effectivity of therapeutic agents themselves (14-16). In order to investigate this further, we are going to analyze DT cells and EDT persister cells from both murine and human PDOs using Chromatin Immune-precipitation Technology Chip-Seq with specific antibodies targeted against the histone proteins H3K4me3 and H3K9me3 which were found to activate downstream signaling pathways responsible for attaining the apoptosis-resistance phenotypes of PDAC after treatment.

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Chavdarov, Anatoliy V. "Special Issue No. – 10, June, 2020 Journal > Special Issue > Special Issue No. – 10, June, 2020 > Page 5 “Quantative Methods in Modern Science” organized by Academic Paper Ltd, Russia MORPHOLOGICAL AND ANATOMICAL FEATURES OF THE GENUS GAGEA SALISB., GROWING IN THE EAST KAZAKHSTAN REGION Authors: Zhamal T. Igissinova,Almash A. Kitapbayeva,Anargul S. Sharipkhanova,Alexander L. Vorobyev,Svetlana F. Kolosova,Zhanat K. Idrisheva, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00041 Abstract: Due to ecological preferences among species of the genus GageaSalisb, many plants are qualified as rare and/or endangered. Therefore, the problem of rational use of natural resources, in particular protection of early spring plant species is very important. However, literary sources analysis only reveals data on the biology of species of this genus. The present research,conducted in the spring of 2017-2019, focuses on anatomical and morphological features of two Altai species: Gagealutea and Gagea minima; these features were studied, clarified and confirmed by drawings and photographs. The anatomical structure of the stem and leaf blade was studied in detail. The obtained research results will prove useful for studies of medicinal raw materials and honey plants. The aforementioned species are similar in morphological features, yet G. minima issmaller in size, and its shoots appear earlier than those of other species Keywords: Flora,gageas,Altai species,vegetative organs., Refference: I. Atlas of areas and resources of medicinal plants of Kazakhstan.Almaty, 2008. II. Baitenov M.S. Flora of Kazakhstan.Almaty: Ġylym, 2001. III. DanilevichV. G. ThegenusGageaSalisb. of WesternTienShan. PhD Thesis, St. Petersburg,1996. IV. EgeubaevaR.A., GemedzhievaN.G. The current state of stocks of medicinal plants in some mountain ecosystems of Kazakhstan.Proceedings of the international scientific conference ‘”Results and prospects for the development of botanical science in Kazakhstan’, 2002. V. Kotukhov Yu.A. New species of the genus Gagea (Liliaceae) from Southern Altai. Bot. Journal.1989;74(11). VI. KotukhovYu.A. ListofvascularplantsofKazakhstanAltai. Botan. Researches ofSiberiaandKazakhstan.2005;11. VII. KotukhovYu. The current state of populations of rare and endangered plants in Eastern Kazakhstan. Almaty: AST, 2009. VIII. Kotukhov Yu.A., DanilovaA.N., AnufrievaO.A. Synopsisoftheonions (AlliumL.) oftheKazakhstanAltai, Sauro-ManrakandtheZaisandepression. BotanicalstudiesofSiberiaandKazakhstan. 2011;17: 3-33. IX. Kotukhov, Yu.A., Baytulin, I.O. Rareandendangered, endemicandrelictelementsofthefloraofKazakhstanAltai. MaterialsoftheIntern. scientific-practical. conf. ‘Sustainablemanagementofprotectedareas’.Almaty: Ridder, 2010. X. Krasnoborov I.M. et al. The determinant of plants of the Republic of Altai. Novosibirsk: SB RAS, 2012. XI. Levichev I.G. On the species status of Gagea Rubicunda. Botanical Journal.1997;6:71-76. XII. Levichev I.G. A new species of the genus Gagea (Liliaceae). Botanical Journal. 2000;7: 186-189. XIII. Levichev I.G., Jangb Chang-gee, Seung Hwan Ohc, Lazkovd G.A.A new species of genus GageaSalisb.(Liliaceae) from Kyrgyz Republic (Western Tian Shan, Chatkal Range, Sary-Chelek Nature Reserve). Journal of Asia-Pacific Biodiversity.2019; 12: 341-343. XIV. Peterson A., Levichev I.G., Peterson J. Systematics of Gagea and Lloydia (Liliaceae) and infrageneric classification of Gagea based on molecular and morphological data. Molecular Phylogenetics and Evolution.2008; 46. XV. Peruzzi L., Peterson A., Tison J.-M., Peterson J. Phylogenetic relationships of GageaSalisb.(Liliaceae) in Italy, inferred from molecular and morphological data matrices. Plant Systematics and Evolution; 2008: 276. XVI. Rib R.D. Honey plants of Kazakhstan. Advertising Digest, 2013. XVII. Scherbakova L.I., Shirshikova N.A. Flora of medicinal plants in the vicinity of Ust-Kamenogorsk. Collection of materials of the scientific-practical conference ‘Unity of Education, Science and Innovation’. Ust-Kamenogorsk: EKSU, 2011. XVIII. syganovA.P. PrimrosesofEastKazakhstan. Ust-Kamenogorsk: EKSU, 2001. XIX. Tsyganov A.P. Flora and vegetation of the South Altai Tarbagatay. Berlin: LAP LAMBERT,2014. XX. Utyasheva, T.R., Berezovikov, N.N., Zinchenko, Yu.K. ProceedingsoftheMarkakolskStateNatureReserve. Ust-Kamenogorsk, 2009. XXI. Xinqi C, Turland NJ. Gagea. Flora of China.2000;24: 117-121. XXII. Zarrei M., Zarre S., Wilkin P., Rix E.M. Systematic revision of the genus GageaSalisb. (Liliaceae) in Iran.BotJourn Linn Soc.2007;154. XXIII. Zarrei M., Wilkin P., Ingroille M.J., Chase M.W. A revised infrageneric classification for GageaSalisb. (Tulipeae; Liliaceae): insights from DNA sequence and morphological data.Phytotaxa.2011:5. View | Download INFLUENCE OF SUCCESSION CROPPING ON ECONOMIC EFFICIENCY OF NO-TILL CROP ROTATIONS Authors: Victor K. Dridiger,Roman S. Stukalov,Rasul G. Gadzhiumarov,Anastasiya A. Voropaeva,Viktoriay A. Kolomytseva, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00042 Abstract: This study was aimed at examining the influence of succession cropping on the economic efficiency of no-till field crop rotations on the black earth in the zone of unstable moistening of the Stavropol krai. A long-term stationary experiment was conducted to examine for the purpose nine field crop rotation patterns different in the number of fields (four to six), set of crops, and their succession in crop rotation. The respective shares of legumes, oilseeds, and cereals in the cropping pattern were 17 to 33, 17 to 40, and 50 to 67 %. It has been established that in case of no-till field crop cultivation the economic efficiency of plant production depends on the set of crops and their succession in rotation. The most economically efficient type of crop rotation is the soya-winter wheat-peas-winter wheat-sunflower-corn six-field rotation with two fields of legumes: in this rotation 1 ha of crop rotation area yields 3 850 grain units per ha at a grain unit prime cost of 5.46 roubles; the plant production output return and profitability were 20,888 roubles per ha and 113 %, respectively. The high production profitabilities provided by the soya-winter wheat-sunflower four-field and the soya-winter-wheat-sunflower-corn-winter wheat five-field crop rotation are 108.7 and 106.2 %, respectively. The inclusion of winter wheat in crop rotation for two years in a row reduces the second winter wheat crop yield by 80 to 100 %, which means a certain reduction in the grain unit harvesting rate to 3.48-3.57 thousands per ha of rotation area and cuts the production profitability down to 84.4-92.3 %. This is why, no-till cropping should not include winter wheat for a second time Keywords: No-till technology,crop rotation,predecessor,yield,return,profitability, Refference: I Badakhova G. Kh. and Knutas A. V., Stavropol Krai: Modern Climate Conditions [Stavropol’skiykray: sovremennyyeklimaticheskiyeusloviya]. Stavropol: SUE Krai Communication Networks, 2007. II Cherkasov G. N. and Akimenko A. S. Scientific Basis of Modernization of Crop Rotations and Formation of Their Systems according to the Specializations of Farms in the Central Chernozem Region [Osnovy moderniz atsiisevooborotoviformirovaniyaikh sistem v sootvetstvii so spetsi-alizatsiyeykhozyaystvTsentral’nogoChernozem’ya]. Zemledelie. 2017; 4: 3-5. III Decree 330 of July 6, 2017 the Ministry of Agriculture of Russia “On Approving Coefficients of Converting to Agricultural Crops to Grain Units [Ob utverzhdeniikoeffitsiyentovperevoda v zernovyyee dinitsysel’s kokhozyaystvennykhkul’tur]. IV Dridiger V. K., About Methods of Research of No-Till Technology [O metodikeissledovaniytekhnologii No-till]//Achievements of Science and Technology of AIC (Dostizheniyanaukiitekhniki APK). 2016; 30 (4): 30-32. V Dridiger V. K. and Gadzhiumarov R. G. Growth, Development, and Productivity of Soya Beans Cultivated On No-Till Technology in the Zone of Unstable Moistening of Stavropol Region [Rost, razvitiyeiproduktivnost’ soiprivozdelyvaniipotekhnologii No-till v zone ne-ustoychivog ouvlazhneniyaStavropol’skogokraya]//Oil Crops RTBVNIIMK (Maslichnyyekul’turyNTBVNIIMK). 2018; 3 (175): 52–57. VI Dridiger V. K., Godunova E. I., Eroshenko F. V., Stukalov R. S., Gadzhiumarov, R. G., Effekt of No-till Technology on erosion resistance, the population of earthworms and humus content in soil (Vliyaniyetekhnologii No-till naprotivoerozionnuyuustoychivost’, populyatsiyudozhdevykhcherveyisoderzhaniyegumusa v pochve)//Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2018; 9 (2): 766-770. VII Karabutov A. P., Solovichenko V. D., Nikitin V. V. et al., Reproduction of Soil Fertility, Productivity and Energy Efficiency of Crop Rotations [Vosproizvodstvoplodorodiyapochv, produktivnost’ ienergeticheskayaeffektivnost’ sevooborotov]. Zemledelie. 2019; 2: 3-7. VIII Kulintsev V. V., Dridiger V. K., Godunova E. I., Kovtun V. I., Zhukova M. P., Effekt of No-till Technology on The Available Moisture Content and Soil Density in The Crop Rotation [Vliyaniyetekhnologii No-till nasoderzhaniyedostupnoyvlagiiplotnost’ pochvy v sevoob-orote]// Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2017; 8 (6): 795-99. IX Kulintsev V. V., Godunova E. I., Zhelnakova L. I. et al., Next-Gen Agriculture System for Stavropol Krai: Monograph [SistemazemledeliyanovogopokoleniyaStavropol’skogokraya: Monogtafiya]. Stavropol: AGRUS Publishers, Stavropol State Agrarian University, 2013. X Lessiter Frank, 29 reasons why many growers are harvesting higher no-till yields in their fields than some university scientists find in research plots//No-till Farmer. 2015; 44 (2): 8. XI Rodionova O. A. Reproduction and Exchange-Distributive Relations in Farming Entities [Vosproizvodstvoiobmenno-raspredelitel’nyyeotnosheniya v sel’skokhozyaystvennykhorganizatsiyakh]//Economy, Labour, and Control in Agriculture (Ekonomika, trud, upravleniye v sel’skomkhozyaystve). 2010; 1 (2): 24-27. XII Sandu I. S., Svobodin V. A., Nechaev V. I., Kosolapova M. V., and Fedorenko V. F., Agricultural Production Efficiency: Recommended Practices [Effektivnost’ sel’skokhozyaystvennogoproizvodstva (metodicheskiyerekomendatsii)]. Moscow: Rosinforagrotech, 2013. XIII Sotchenko V. S. Modern Corn Cultivation Technologies [Sovremennayatekhnologiyavozdelyvaniya]. Moscow: Rosagrokhim, 2009. View | Download DEVELOPMENT AND TESTING OF AUTONOMOUS PORTABLE SEISMOMETER DESIGNED FOR USE AT ULTRALOW TEMPERATURES IN ARCTIC ENVIRONMENT Authors: Mikhail A. Abaturov,Yuriy V. Sirotinskiy, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00043 Abstract: This paper is concerned with solving one of the issues of the general problem of designing geophysical equipment for the natural climatic environment of the Arctic. The relevance of the topic has to do with an increased global interest in this region. The paper is aimed at considering the basic principles of developing and the procedure of testing seismic instruments for use at ultralow climatic temperatures. In this paper the indicated issue is considered through the example of a seismic module designed for petroleum and gas exploration by passive seismoacoustic methods. The seismic module is a direct-burial portable unit of around 5 kg in weight, designed to continuously measure and record microseismic triaxial orthogonal (ZNE) noise in a range from 0.1 to 45 Hz during several days in autonomous mode. The functional chart of designing the seismic module was considered, and concrete conclusions were made for choosing the necessary components to meet the ultralow-temperature operational requirements. The conclusions made served for developing appropriate seismic module. In this case, the components and tools used included a SAFT MP 176065 xc low-temperature lithium cell, industrial-spec electronic component parts, a Zhaofeng Geophysical ZF-4.5 Chinese primary electrodynamic seismic sensor, housing seal parts made of frost-resistant silicone materials, and finely dispersed silica gel used as water-retaining sorbent to avoid condensation in the housing. The paper also describes a procedure of low-temperature collation tests at the lab using a New Brunswick Scientific freezing plant. The test results proved the operability of the developed equipment at ultralow temperatures down to -55°C. In addition, tests were conducted at low microseismic noises in the actual Arctic environment. The possibility to detect signals in a range from 1 to 10 Hz at the level close to the NLNM limit (the Peterson model) has been confirmed, which allows monitoring and exploring petroleum and gas deposits by passive methods. As revealed by this study, the suggested approaches are efficient in developing high-precision mobile seismic instruments for use at ultralow climatic temperatures. The solution of the considered instrumentation and methodical issues is of great practical significance as a constituent of the generic problem of Arctic exploration. Keywords: Seismic instrumentation,microseismic monitoring,Peterson model,geological exploration,temperature ratings,cooling test, Refference: I. AD797: Ultralow Distortion, Ultralow Noise Op Amp, Analog Devices, Inc., Data Sheet (Rev. K). Analog Devices, Inc. URL: https://www.analog.com/media/en/technical-documentation/data-sheets/AD797.pdf(Date of access September 2, 2019). II. Agafonov, V. M., Egorov, I. V., and Shabalina, A. S. Operating Principles and Technical Characteristics of a Small-Sized Molecular–Electronic Seismic Sensor with Negative Feedback [Printsipyraboty I tekhnicheskiyekharakteristikimalogabaritnogomolekulyarno-elektronnogoseysmodatchika s otritsatel’noyobratnoysvyaz’yu]. SeysmicheskiyePribory (Seismic Instruments). 2014; 50 (1): 1–8. DOI: 10.3103/S0747923914010022. III. Antonovskaya, G., Konechnaya, Ya.,Kremenetskaya, E., Asming, V., Kvaema, T., Schweitzer, J., Ringdal, F. Enhanced Earthquake Monitoring in the European Arctic. Polar Science. 2015; 1 (9): 158-167. IV. Anthony, R. E., Aster, R. C., Wiens, D., Nyblade, Andr., Anandakrishnan, Sr., Huerta, Audr., Winberry, J. P., Wilson, T., and Rowe, Ch. The Seismic Noise Environment of Antarctica. Seismological Research Letters. 2015; 86(1): 89-100. DOI: 10.1785/0220150005 V. Brincker, R., Lago, T. L., Andersen, P., and Ventura, C. Improving the Classical Geophone Sensor Element by Digital Correction. In Conference Proceedings: IMAC-XXIII: A Conference & Exposition on Structural Dynamics Society for Experimental Mechanics, 2005. URL: https://www.researchgate.net/publication/242452637_Improving_the_Classical_Geophone_Sensor_Element_by_Digital_Correction(Date of access September 2, 2019). VI. Bylaw 164 of the State Committee for Construction of the Russian Federation “On adopting amendments to SNiP 31-01-99 “Construction climatology”. URL: https://base.garant.ru/2322381/(Date of access September 2, 2019). VII. Chao Xu, Junbo Wang, Deyong Chen, Jian Chen, Bowen Liu, Wenjie Qi, XichenZheng, Hua Wei, Guoqing Zhang. The Electrochemical Seismometer Based on a Novel Designed.Sensing Electrode for Undersea Exploration. 20th International Conference on Solid-State Sensors, Actuators and Microsystems &Eurosensors XXXIII (TRANSDUCERS &EUROSENSORS XXXIII). IEEE, 2019. DOI: 10.1109/TRANSDUCERS.2019.8808450. VIII. Chebotareva, I. Ya. New algorithms of emission tomography for passive seismic monitoring of a producing hydrocarbon deposit: Part I. Algorithms of processing and numerical simulation [Novyye algoritmyemissionnoyto mografiidlyapassivnogoseysmicheskogomonitoringarazrabatyvayemykhmestorozhdeniyuglevodorodov. Chast’ I: Algoritmyobrabotki I chislennoyemodelirovaniye]. FizikaZemli. 2010; 46(3):187-98. DOI: 10.1134/S106935131003002X IX. Danilov, A. V. and Konechnaya, Ya. V. Analytical comparison of seismic instruments for stationary surveys in the Arctic [Sravnitel’nyyanalizseysmicheskoyapparaturydlyastatsionarnykhnablyudeniy v Arktike]. DSYS. URL: https://dsys.ru/upload/id254_docPDF_FranzJosefLand.pdf(Date of access September 2, 2019). X. Dew point temperature calculator. Maple Tech. International LLC. URL: https://www.calculator.net/dew-point-calculator.html?airtemperature=20&airtemperatureunit=celsius&humidity=0.34&dewpoint=&dewpointunit=celsius&x=51&y=14(Date of access September 2, 2019). XI. Frolov, A. S. Matching of wave fields recorded by different geophysical receivers [Soglasovaniyevolnovykhpoley, poluchennykh s primeneniyemrazlichnoyregistriruyushcheyapparatury]. Abstracts IX International scientific and technical conference competition of young specialists “Geophysics-2013”. Saint-Petersburg: Gubkin University, 2013. URL: https://www.gubkin.ru/faculty/geology_and_geophysics/chairs_and_departments/exploration_geophysics_and_computers_systems/files/2013_SPb_Frolov.pdf. (Date of access September 2, 2019). XII. Gibbons, S. J., Asming, V., Fedorov, A., Fyen, J., Kero, J., Kozlovskaya, E., Kværna, T., Liszka, L., Näsholm, S.P., Raita, T., Roth, M., Tiira, T., Vinogradov, Yu. The European Arctic: A laboratory for seismoacoustic studies. Seism. Res. Letters. 2015; 86 (3): 917–928. XIII. GOST 8.395-80. State system for ensuring the uniformity of measurements. Reference conditions of measurements while calibrating. General requirements [Gosudarstvennayasistemaobespecheniyaedinstvaizmereniy. Normal’nyyeusloviyaizmereniypripoverke. Obshchiyetrebovaniya]. Moscow: Standartinform, 2008. URL: http://gostrf.com/normadata/1/4294821/4294821960.pdf (Date of access September 2, 2019). XIV. Guralp 6TD. Operators’ Guide. Document Number: MAN-T60-0002, Issue J: April, 2017. Guralp Systems Limited. 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Passive seismic tomography: A passive concept actively evolving. First Break. 2012; 30 (7): 83-90. XXII. Matveev, I. V. and Matveeva, N. V. Portable seismic recorder “SEISAR-5” with very low energy consumption for autonomous work in harsh climatic conditions [Portativnyyseysmicheskiyregistrator «Seysar-5» s ochen’ nizkimenergopotrebleniyemdlyaavtonomnoyraboty v slozhnykhklimatic heskikhusloviyakh]. Nauka I tekhnologicheskierazrabotki (Science and Technological Developments). 2017; 96 (3): 33-40. [Special Issue “Applied Geophysics: New Developments and Results. Part 1. Seismology and Seismic Exploration]. DOI: 10.21455/std2017.3-3. XXIII. Mishra, R. The Temperature Ratings of Electronic Parts.Electronics Cooling magazine. URL: http://www.electronics-cooling.com/2004/02/the-temperature-ratings-of-electronic-parts(Date of access September 2, 2019). XXIV. Moore, Sue E.; Stabeno, Phyllis J.; Van Pelt, Thomas I. The Synthesis of Arctic Research (SOAR) project. 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View | Download COMPARATIVE ANALYSIS OF RESULTS OF TREATMENT OF PATIENTS WITH FOOT PATHOLOGY WHO UNDERWENT WEIL OPEN OSTEOTOMY BY CLASSICAL METHOD AND WITHOUT STEOSYNTHESIS Authors: Yuriy V. Lartsev,Dmitrii A. Rasputin,Sergey D. Zuev-Ratnikov,Pavel V.Ryzhov,Dmitry S. Kudashev,Anton A. Bogdanov, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00044 Abstract: The article considers the problem of surgical correction of the second metatarsal bone length. The article analyzes the results of treatment of patients with excess length of the second metatarsal bones that underwent osteotomy with and without osteosynthesis. The results of treatment of patients who underwent metatarsal shortening due to classical Weil-osteotomy with and without osteosynthesis were analyzed. The first group consisted of 34 patients. They underwent classical Weil osteotomy. The second group included 44 patients in whomosteotomy of the second metatarsal bone were not by the screw. When studying the results of the treatment in the immediate postoperative period, weeks 6, 12, slightly better results were observed in patients of the first group, while one year after surgical treatment the results in both groups were comparable. One year after surgical treatment, there were 2.9% (1 patient) of unsatisfactory results in the first group and 4.5% (2 patients) in the second group. Considering the comparability of the results of treatment in remote postoperative period, the choice of concrete method remains with the operating surgeon. Keywords: Flat feet,hallux valgus,corrective osteotomy,metatarsal bones, Refference: I. A novel modification of the Stainsby procedure: surgical technique and clinical outcome [Text] / E. Concannon, R. MacNiocaill, R. Flavin [et al.] // Foot Ankle Surg. – 2014. – Dec., Vol. 20(4). – P. 262–267. II. Accurate determination of relative metatarsal protrusion with a small intermetatarsal angle: a novel simplified method [Text] / L. Osher, M.M. Blazer, S. Buck [et al.] // J. Foot Ankle Surg. – 2014. – Sep.-Oct., Vol. 53(5). – P. 548–556. III. Argerakis, N.G. The radiographic effects of the scarf bunionectomy on rearfoot alignment [Text] / N.G. Argerakis, L.Jr. Weil, L.S. Sr. Weil // Foot Ankle Spec. – 2015. – Apr., Vol. 8(2). – P. 89–94. IV. Bauer, T. Percutaneous forefoot surgery [Text] / T. Bauer // Orthop. Traumatol. Surg. Res. – 2014. – Feb., Vol. 100(1 Suppl.). – P. S191–S204. V. Biomechanical Evaluation of Custom Foot Orthoses for Hallux Valgus Deformity [Text] // J. Foot Ankle Surg. – 2015. – Sep.-Oct., Vol.54(5). – P. 852–855. VI. Chopra, S. Characterization of gait in female patients with moderate to severe hallux valgus deformity [Text] / S. Chopra, K. Moerenhout, X. Crevoisier // Clin. Biomech. (Bristol, Avon). – 2015. – Jul., Vol. 30(6). – P. 629–635. VII. Computer assisted planning and custom-made surgical guide for malunited pronation deformity after first metatarsophalangeal joint arthrodesis in rheumatoid arthritis: a case report [Text] / M. Hirao, S. Ikemoto, H. Tsuboi [et al.] // Comput. Aided Surg. – 2014. – Vol. 19(1-3). – P. 13–19. VIII. Correlation between static radiographic measurements and intersegmental angular measurements during gait using a multisegment foot model [Text] / D.Y. Lee, S.G. Seo, E.J. Kim [et al.] // Foot Ankle Int. – 2015. – Jan., Vol.36(1). – P. 1–10. IX. Correlative study between length of first metatarsal and transfer metatarsalgia after osteotomy of first metatarsal [Text]: [Article in Chinese] / F.Q. Zhang, B.Y. Pei, S.T. Wei [et al.] // Zhonghua Yi XueZaZhi. – 2013. – Nov. 19, Vol. 93(43). – P. 3441–3444. X. Dave, M.H. Forefoot Deformity in Rheumatoid Arthritis: A Comparison of Shod and Unshod Populations [Text] / M.H. Dave, L.W. Mason, K. Hariharan // Foot Ankle Spec. – 2015. – Oct., Vol. 8(5). – P. 378–383. XI. Does arthrodesis of the first metatarsophalangeal joint correct the intermetatarsal M1M2 angle? Analysis of a continuous series of 208 arthrodeses fixed with plates [Text] / F. Dalat, F. Cottalorda, M.H. Fessy [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6). – P. 709–714. XII. Dynamic plantar pressure distribution after percutaneous hallux valgus correction using the Reverdin-Isham osteotomy [Text]: [Article in Spanish] / G. Rodríguez-Reyes, E. López-Gavito, A.I. Pérez-Sanpablo [et al.] // Rev. Invest. Clin. – 2014. – Jul., Vol. 66, Suppl. 1. – P. S79-S84. XIII. Efficacy of Bilateral Simultaneous Hallux Valgus Correction Compared to Unilateral [Text] / A.V. Boychenko, L.N. Solomin, S.G. Parfeyev [et al.] // Foot Ankle Int. – 2015. – Nov., Vol. 36(11). – P. 1339–1343. XIV. Endolog technique for correction of hallux valgus: a prospective study of 30 patients with 4-year follow-up [Text] / C. Biz, M. Corradin, I. Petretta [et al.] // J. OrthopSurg Res. – 2015. – Jul. 2, № 10. – P. 102. XV. First metatarsal proximal opening wedge osteotomy for correction of hallux valgus deformity: comparison of straight versus oblique osteotomy [Text] / S.H. Han, E.H. Park, J. Jo [et al.] // Yonsei Med. J. – 2015. – May, Vol. 56(3). – P. 744–752. XVI. Long-term outcome of joint-preserving surgery by combination metatarsal osteotomies for shortening for forefoot deformity in patients with rheumatoid arthritis [Text] / H. Niki, T. Hirano, Y. Akiyama [et al.] // Mod. Rheumatol. – 2015. – Sep., Vol. 25(5). – P. 683–638. XVII. Maceira, E. Transfer metatarsalgia post hallux valgus surgery [Text] / E. Maceira, M. Monteagudo // Foot Ankle Clin. – 2014. – Jun., Vol. 19(2). – P.285–307. XVIII. Nielson, D.L. Absorbable fixation in forefoot surgery: a viable alternative to metallic hardware [Text] / D.L. Nielson, N.J. Young, C.M. Zelen // Clin. Podiatr. Med. Surg. – 2013. – Jul., Vol. 30(3). – P. 283–293 XIX. Patient’s satisfaction after outpatient forefoot surgery: Study of 619 cases [Text] / A. Mouton, V. Le Strat, D. Medevielle [et al.] // Orthop. Traumatol. Surg. Res. – 2015. – Oct., Vol. 101(6 Suppl.). – P. S217–S220. XX. Preference of surgical procedure for the forefoot deformity in the rheumatoid arthritis patients–A prospective, randomized, internal controlled study [Text] / M. Tada, T. Koike, T. Okano [et al.] // Mod. Rheumatol. – 2015. – May., Vol. 25(3). – P.362–366. XXI. Redfern, D. Percutaneous Surgery of the Forefoot [Text] / D. Redfern, J. Vernois, B.P. Legré // Clin. Podiatr. Med. Surg. – 2015. – Jul., Vol. 32(3). – P. 291–332. XXII. Singh, D. Bullous pemphigoid after bilateral forefoot surgery [Text] / D. Singh, A. Swann // Foot Ankle Spec. – 2015. – Feb., Vol. 8(1). – P. 68–72. XXIII. Treatment of moderate hallux valgus by percutaneous, extra-articular reverse-L Chevron (PERC) osteotomy [Text] / J. Lucas y Hernandez, P. Golanó, S. Roshan-Zamir [et al.] // Bone Joint J. – 2016. – Mar., Vol. 98-B(3). – P. 365–373. XXIV. Weil, L.Jr. Scarf osteotomy for correction of hallux abducto valgus deformity [Text] / L.Jr. Weil, M. Bowen // Clin. Podiatr. Med. Surg. – 2014. – Apr., Vol.31(2). – P. 233–246. View | Download QUANTITATIVE ULTRASONOGRAPHY OF THE STOMACH AND SMALL INTESTINE IN HEALTHYDOGS Authors: Roman A. Tcygansky,Irina I. Nekrasova,Angelina N. Shulunova,Alexander I.Sidelnikov, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00045 Abstract: Purpose.To determine the quantitative echogenicity indicators (and their ratio) of the layers of stomach and small intestine wall in healthy dogs. Methods. A prospective 3-year study of 86 healthy dogs (aged 1-7 yrs) of different breeds and of both sexes. Echo homogeneity and echogenicity of the stomach and intestines wall were determined by the method of Silina, T.L., et al. (2010) in absolute values of average brightness levels of ultrasound image pixels using the 8-bit scale with 256 shades of gray. Results. Quantitative echogenicity indicators of the stomach and the small intestine wall in dogs were determined. Based on the numerical values characterizing echogenicity distribution in each layer of a separate structure of the digestive system, the coefficient of gastric echogenicity is determined as 1:2.4:1.1 (mucosa/submucosa/muscle layers, respectively), the coefficient of duodenum and jejunum echogenicity is determined as 1:3.5:2 and that of ileum is 1:1.8:1. Clinical significance. The echogenicity coefficient of the wall of the digestive system allows an objective assessment of the stomach and intestines wall and can serve as the basis for a quantitative assessment of echogenicity changes for various pathologies of the digestive system Keywords: Ultrasound (US),echogenicity,echogenicity coefficient,digestive system,dogs,stomach,intestines, Refference: I. Agut, A. Ultrasound examination of the small intestine in small animals // Veterinary focus. 2009.Vol. 19. No. 1. P. 20-29. II. Bull. 4.RF patent 2398513, IPC51A61B8 / 00 A61B8 / 14 (2006.01) A method for determining the homoechogeneity and the degree of echogenicity of an ultrasound image / T. Silina, S. S. Golubkov. – No. 2008149311/14; declared 12/16/2008; publ. 09/10/2010 III. Choi, M., Seo, M., Jung, J., Lee, K., Yoon, J., Chang, D., Park, RD. Evaluation of canine gastric motility with ultrasonography // J. of Veterinary Medical Science. – 2002. Vol. 64. – № 1. – P. 17-21. IV. Delaney, F., O’Brien, R.T., Waller, K.Ultrasound evaluation of small bowel thickness compared to weight in normal dogs // Veterinary Radiology and Ultrasound. 2003 Vol. 44, № 5. Р 577-580. V. Diana, A., Specchi, S., Toaldo, M.B., Chiocchetti, R., Laghi, A., Cipone, M. Contrast-enhanced ultrasonography of the small bowel in healthy cats // Veterinary Radiology and Ultrasound. – 2011. – Vol. 52, № 5. – Р. 555-559. VI. Garcia, D.A.A., Froes, T.R. Errors in abdominal ultrasonography in dogs and cats // J. of Small Animal Practice. – 2012. Vol. 53. – № 9. – P. 514-519. VII. Garcia, D.A.A., Froes, T.R. Importance of fasting in preparing dogs for abdominal ultrasound examination of specific organs // J. of Small Animal Practice. – 2014. Vol. 55. – № 12. – P. 630-634. VIII. Gaschen, L., Granger, L.A., Oubre, O., Shannon, D., Kearney, M., Gaschen, F. The effects of food intake and its fat composition on intestinal echogenicity in healthy dogs // Veterinary Radiology and Ultrasound. 2016. Vol. 57. № 5. P. 546-550 IX. Gaschen, L., Kircher, P., Stussi, A., Allenspach, K., Gaschen, F., Doherr, M., Grone, A. Comparison of ultrasonographic findings with clinical activity index (CIBDAI) and diagnosis in dogs with chronic enteropathies // Veterinary radiology and ultrasound. – 2008. – Vol. 49. – № 1. – Р. 56-64. X. Gil, E.M.U. Garcia, D.A.A. Froes, T.R. In utero development of the fetal intestine: Sonographic evaluation and correlation with gestational age and fetal maturity in dogs // Theriogenology. 2015. Vol. 84, №5. Р. 681-686. XI. Gladwin, N.E. Penninck, D.G., Webster, C.R.L. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs // American Journal of Veterinary Research. 2014. Vol. 75, №4. Р. 349-353. XII. Gory, G., Rault, D.N., Gatel, L, Dally, C., Belli, P., Couturier, L., Cauvin, E. Ultrasonographic characteristics of the abdominal esophagus and cardia in dogs // Veterinary Radiology and Ultrasound. 2014. Vol. 55, № 5. P. 552-560. XIII. Günther, C.S. Lautenschläger, I.E., Scholz, V.B. Assessment of the inter- and intraobserver variability for sonographical measurement of intestinal wall thickness in dogs without gastrointestinal diseases | [Inter-und Intraobserver-Variabilitätbei der sonographischenBestimmung der Darmwanddicke von HundenohnegastrointestinaleErkrankungen] // Tierarztliche Praxis Ausgabe K: Kleintiere – Heimtiere. 2014. Vol. 42 №2. Р. 71-78. XIV. Hanazono, K., Fukumoto, S., Hirayama, K., Takashima, K., Yamane, Y., Natsuhori, M., Kadosawa, T., Uchide, T. Predicting Metastatic Potential of gastrointestinal stromal tumors in dog by ultrasonography // J. of Veterinary Medical Science. – 2012. Vol. 74. – № 11. – P. 1477-1482. XV. Heng, H.G., Lim, Ch.K., Miller, M.A., Broman, M.M.Prevalence and significance of an ultrasonographic colonic muscularishyperechoic band paralleling the serosal layer in dogs // Veterinary Radiology and Ultrasound. 2015. Vol. 56 № 6. P. 666-669. XVI. Ivančić, M., Mai, W. Qualitative and quantitative comparison of renal vs. hepatic ultrasonographic intensity in healthy dogs // Veterinary Radiology and Ultrasound. 2008. Vol. 49. № 4. Р. 368-373. XVII. Lamb, C.R., Mantis, P. Ultrasonographic features of intestinal intussusception in 10 dogs // J. of Small Animal Practice. – 2008. Vol. 39. – № 9. – P. 437-441. XVIII. Le Roux, A. B., Granger, L.A., Wakamatsu, N, Kearney, M.T., Gaschen, L.Ex vivo correlation of ultrasonographic small intestinal wall layering with histology in dogs // Veterinary Radiology and Ultrasound.2016. Vol. 57. № 5. P. 534-545. XIX. Nielsen, T. High-frequency ultrasound of Peyer’s patches in the small intestine of young cats / T. Nielsen [et al.] // Journal of Feline Medicine and Surgery. – 2015. – Vol. 18, № 4. – Р. 303-309. XX. PenninckD.G. Gastrointestinal tract. In Nyland T.G., Mattoon J.S. (eds): Small Animal Diagnostic Ultrasound. Philadelphia: WB Saunders. 2002, 2nd ed. Р. 207-230. XXI. PenninckD.G. Gastrointestinal tract. In: PenninckD.G.,d´Anjou M.A. Atlas of Small Animal Ultrasonography. Blackwell Publishing, Iowa. 2008. Р. 281-318. XXII. Penninck, D.G., Nyland, T.G., Kerr, L.Y., Fisher, P.E. Ultrasonographic evaluation of gastrointestinal diseases in small animals // Veterinary Radiology. 1990. Vol. 31. №3. P. 134-141. XXIII. Penninck, D.G.,Webster, C.R.L.,Keating, J.H. The sonographic appearance of intestinal mucosal fibrosis in cats // Veterinary Radiology and Ultrasound. – 2010. – Vol. 51, № 4. – Р. 458-461. XXIV. Pollard, R.E.,Johnson, E.G., Pesavento, P.A., Baker, T.W., Cannon, A.B., Kass, P.H., Marks, S.L. Effects of corn oil administered orally on conspicuity of ultrasonographic small intestinal lesions in dogs with lymphangiectasia // Veterinary Radiology and Ultrasound. 2013. Vol. 54. № 4. P. 390-397. XXV. Rault, D.N., Besso, J.G., Boulouha, L., Begon, D., Ruel, Y. Significance of a common extended mucosal interface observed in transverse small intestine sonograms // Veterinary Radiology and Ultrasound. 2004. Vol. 45. №2. Р. 177-179. XXVI. Sutherland-Smith, J., Penninck, D.G., Keating, J.H., Webster, C.R.L. Ultrasonographic intestinal hyperechoic mucosal striations in dogs are associated with lacteal dilation // Veterinary Radiology and Ultrasound. – 2007. Vol. 48. – № 1. – P. 51-57. View | Download EVALUATION OF ADAPTIVE POTENTIAL IN MEDICAL STUDENTS IN THE CONTEXT OF SEASONAL DYNAMICS Authors: Larisa A. Merdenova,Elena A. Takoeva,Marina I. Nartikoeva,Victoria A. Belyayeva,Fatima S. Datieva,Larisa R. Datieva, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00046 Abstract: The aim of this work was to assess the functional reserves of the body to quantify individual health; adaptation, psychophysiological characteristics of the health quality of medical students in different seasons of the year. When studying the temporal organization of physiological functions, the rhythm parameters of physiological functions were determined, followed by processing the results using the Cosinor Analysis program, which reveals rhythms with an unknown period for unequal observations, evaluates 5 parameters of sinusoidal rhythms (mesor, amplitude, acrophase, period, reliability). The essence of desynchronization is the mismatch of circadian rhythms among themselves or destruction of the rhythms architectonics (instability of acrophases or their disappearance). Desynchronization with respect to the rhythmic structure of the body is of a disregulatory nature, most pronounced in pathological desynchronization. High neurotism, increased anxiety reinforces the tendency to internal desynchronization, which increases with stress. During examination stress, students experience a decrease in the stability of the temporary organization of the biosystem and the tension of adaptive mechanisms develops, which affects attention, mental performance and the quality of adaptation to the educational process. Time is shortened and the amplitude of the “initial minute” decreases, personal and situational anxiety develops, and the level of psychophysiological adaptation decreases. The results of the work are priority because they can be used in assessing quality and level of health. Keywords: Desynchronosis,biorhythms,psycho-emotional stress,mesor,acrophase,amplitude,individual minute, Refference: I. Arendt, J., Middleton, B. Human seasonal and circadian studies in Antarctica (Halley, 75_S) – General and Comparative Endocrinology. 2017: 250-259. (http://dx.doi.org/10.1016/j.ygcen.2017.05.010). II. BalandinYu.P. A brief methodological guide on the use of the agro-industrial complex “Health Sources” / Yu.P. Balandin, V.S. Generalov, V.F. Shishlov. Ryazan, 2007. III. Buslovskaya L.K. Adaptation reactions in students at exam stress/ L.K. Buslovskaya, Yu.P. Ryzhkova. Scientific bulletin of Belgorod State University. Series: Natural Sciences. 2011;17(21):46-52. IV. Chutko L. S. Sindromjemocionalnogovygoranija – Klinicheskie I psihologicheskieaspekty./ L.S Chutko. Moscow: MEDpress-inform, 2013. V. Eroshina K., Paul Wilkinson, Martin Mackey. The role of environmental and social factors in the occurrence of diseases of the respiratory tract in children of primary school age in Moscow. Medicine. 2013:57-71. VI. Fagrell B. “Microcirculation of the Skin”. The physiology and pharmacology of the microcirculation. 2013:423. VII. Gurova O.A. Change in blood microcirculation in students throughout the day. New research. 2013; 2 (35):66-71. VIII. Khetagurova L.G. – Stress/Ed. L.G. Khetagurov. Vladikavkaz: Project-Press Publishing House, 2010. IX. Khetagurova L.G., Urumova L.T. et al. Stress (chronomedical aspects). International Journal of Experimental Education 2010; 12: 30-31. X. Khetagurova L.G., Salbiev K.D., Belyaev S.D., Datieva F.S., Kataeva M.R., Tagaeva I.R. Chronopathology (experimental and clinical aspects/ Ed. L.G. Khetagurov, K.D. Salbiev, S.D.Belyaev, F.S. Datiev, M.R. Kataev, I.R. Tagaev. Moscow: Science, 2004. XI. KlassinaS.Ya. Self-regulatory reactions in the microvasculature of the nail bed of fingers in person with psycho-emotional stress. Bulletin of new medical technologies, 2013; 2 (XX):408-412. XII. Kovtun O.P., Anufrieva E.V., Polushina L.G. Gender-age characteristics of the component composition of the body in overweight and obese schoolchildren. Medical Science and Education of the Urals. 2019; 3:139-145. XIII. Kuchieva M.B., Chaplygina E.V., Vartanova O.T., Aksenova O.A., Evtushenko A.V., Nor-Arevyan K.A., Elizarova E.S., Efremova E.N. A comparative analysis of the constitutional features of various generations of healthy young men and women in the Rostov Region. Modern problems of science and education. 2017; 5:50-59. XIV. Mathias Adamsson1, ThorbjörnLaike, Takeshi Morita – Annual variation in daily light expo-sure and circadian change of melatonin and cortisol consent rations at a northern latitude with large seasonal differences in photoperiod length – Journal of Physiological Anthropology. 2017; 36: 6 – 15. XV. Merdenova L.A., Tagaeva I.R., Takoeva E.A. Features of the study of biological rhythms in children. The results of fundamental and applied research in the field of natural and technical sciences. Materials of the International Scientific and Practical Conference. Belgorod, 2017, pp. 119-123. XVI. Ogarysheva N.V. The dynamics of mental performance as a criterion for adapting to the teaching load. Bulletin of the Samara Scientific Center of the Russian Academy of Sciences. 2014;16:5 (1): S.636-638. XVII. Pekmezovi T. Gene-environment interaction: A genetic-epidemiological approach. Journal of Medical Biochemistry. 2010;29:131-134. XVIII. Rapoport S.I., Chibisov S.M. Chronobiology and chronomedicine: history and prospects/Ed. S.M. Chibisov, S.I. Rapoport ,, M.L. Blagonravova. Chronobiology and Chronomedicine: Peoples’ Friendship University of Russia (RUDN) Press. Moscow, 2018. XIX. Roustit M., Cracowski J.L. “Non-invasive assessment of skin microvascular function in humans: an insight into methods” – Microcirculation 2012; 19 (1): 47-64. XX. Rud V.O., FisunYu.O. – References of the circadian desinchronosis in students. Ukrainian Bulletin of Psychoneurology. 2010; 18(2) (63): 74-77. XXI. Takoeva Z. A., Medoeva N. O., Berezova D. T., Merdenova L. A. et al. Long-term analysis of the results of chronomonitoring of the health of the population of North Ossetia; Vladikavkaz Medical and Biological Bulletin. 2011; 12(12,19): 32-38. XXII. Urumova L.T., Tagaeva I.R., Takoeva E.A., Datieva L.R. – The study of some health indicators of medical students in different periods of the year. Health and education in the XXI century. 2016; 18(4): 94-97. XXIII. Westman J. – Complex diseases. In: Medical genetics for the modern clinician. USA: Lippincott Williams & Wilkins, 2006. XXIV. Yadrischenskaya T.V. Circadian biorhythms of students and their importance in educational activities. Problems of higher education. Pacific State University Press. 2016; 2:176-178. View | Download TRIADIC COMPARATIVE ANALYSIS Authors: Stanislav A.Kudzh,Victor Ya. Tsvetkov, DOI: https://doi.org/10.26782/jmcms.spl.10/2020.06.00047 Abstract: The present study of comparison methods based on the triadic model introduces the following concepts: the relation of comparability and the relation of comparison, and object comparison and attributive comparison. The difference between active and passive qualitative comparison is shown, two triadic models of passive and active comparison and models for comparing two and three objects are described. Triadic comparison models are proposed as an alternative to dyadic comparison models. Comparison allows finding the common and the different; this approach is proposed for the analysis of the nomothetic and ideographic method of obtaining knowledge. The nomothetic method identifies and evaluates the general, while the ideographic method searches for unique in parameters and in combinations of parameters. Triadic comparison is used in systems and methods of argumentation, as well as in the analysis of consistency/inconsistency. Keywords: Comparative analysis,dyad,triad,triadic model,comparability relation,object comparison,attributive comparison,nomothetic method,ideographic method, Refference: I. AltafS., Aslam.M.Paired comparison analysis of the van Baarenmodel using Bayesian approach with noninformativeprior.Pakistan Journal of Statistics and Operation Research 8(2) (2012) 259{270. II. AmooreJ. E., VenstromD Correlations between stereochemical assessments and organoleptic analysis of odorous compounds. Olfaction and Taste (2016) 3{17. III. BarnesJ., KlingerR. Embedding projection for targeted cross-lingual sentiment: model comparisons and a real-world study. Journal of Artificial Intelligence Research 66 (2019) 691{742. doi.org/10.1613/jair.1.11561 IV. Castro-SchiloL., FerrerE.Comparison of nomothetic versus idiographic-oriented methods for making predictions about distal outcomes from time series data. Multivariate Behavioral Research 48(2) (2013) 175{207. V. De BonaG.et al. Classifying inconsistency measures using graphs. Journal of Artificial Intelligence Research 66 (2019) 937{987. VI. FideliR. La comparazione. Milano: Angeli, 1998. VII. GordonT. F., PrakkenH., WaltonD. The Carneades model of argument and burden of proof. Artificial Intelligence 10(15) (2007) 875{896. VIII. GrenzS.J. The social god and the relational self: A Triad theology of the imago Dei. Westminster: John Knox Press, 2001. IX. HermansH.J. M.On the integration of nomothetic and idiographic research methods in the study of personal meaning.Journal of Personality 56(4) (1988) 785{812. X. JamiesonK. G., NowakR. Active ranking using pairwise comparisons.Advances in Neural Information Processing Systems (2011) 2240{2248. XI. JongsmaC.Poythress’s triad logic: a review essay. Pro Rege 42(4) (2014) 6{15. XII. KärkkäinenV.M. Trinity and Religious Pluralism: The Doctrine of the Trinity in Christian Theology of Religions. London: Routledge, 2017. XIII. KudzhS. A., TsvetkovV.Ya. Triadic systems. Russian Technology Magazine 7(6) (2019) 74{882. XIV. NelsonK.E.Some observations from the perspective of the rare event cognitive comparison theory of language acquisition.Children’s Language 6 (1987) 289{331. XV. NiskanenA., WallnerJ., JärvisaloM.Synthesizing argumentation frameworks from examples. Journal of Artificial Intelligence Research 66 (2019) 503{554. XVI. PührerJ.Realizability of three-valued semantics for abstract dialectical frameworks.Artificial Intelligence 278 (2020) 103{198. XVII. SwansonG.Frameworks for comparative research: structural anthropology and the theory of action. In: Vallier, Ivan (Ed.). Comparative methods in sociology: essays on trends and applications.Berkeley: University of California Press, 1971 141{202. XVIII. TsvetkovV.Ya.Worldview model as the result of education.World Applied Sciences Journal 31(2) (2014) 211{215. XIX. TsvetkovV. Ya. Logical analysis and variable scales. Slavic Forum 4(22) (2018) 103{109. XX. Wang S. et al. Transit traffic analysis zone delineating method based on Thiessen polygon. Sustainability 6(4) (2014) 1821{1832. View | Download DEVELOPING TECHNOLOGY OF CREATING WEAR-RESISTANT CERAMIC COATING FOR ICE CYLINDER." JOURNAL OF MECHANICS OF CONTINUA AND MATHEMATICAL SCIENCES spl10, no. 1 (June 28, 2020). http://dx.doi.org/10.26782/jmcms.spl.10/2020.06.00048.

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