Academic literature on the topic 'Progesterone'
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Journal articles on the topic "Progesterone"
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Lubis, Pika Novriani. "Efektivitas Progesteron Oral dan Vagina pada Tata Laksana Abortus Imminens." Cermin Dunia Kedokteran 50, no. 6 (May 31, 2023): 339–41. http://dx.doi.org/10.55175/cdk.v50i6.922.
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Abortus imminens adalah perdarahan yang terjadi sebelum usia kehamilan 20 minggu, tanpa keluarnya janin. Selama kehamilan, progesteron berperan dalam proses implantasi janin ke dalam rahim. Beberapa penelitian menunjukkan bahwa progesteron bermanfaat dalam penanganan abortus imminens, baik dalam bentuk oral maupun supositoria. Sediaan oral terbukti lebih efektif dibandingkan progesteron vaginal.
Threatened miscarriage or imminent abortion is vaginal bleeding that happened before a 20-week gestation without fetus expulsion. During pregnancy, progesterone plays a role in the process of implanting the fetus into the uterus. Several studies have shown that oral and suppository progesterone are beneficial for imminent abortion treatment, both in oral and suppository form. Oral preparations have proved to be more effective than vaginal progesterone.
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Setiawan, Angga, Elis Dihansih, and Desy Zamanti. "PENGGUNAAN PREPARAT PROGESTERON DAN HORMON GnRH DALAM PENENTUAN ESTRUS PADA PROGRAM SUPEROVULASI SAPI LIMOSIN." JURNAL PERTANIAN 8, no. 1 (April 14, 2017): 7. http://dx.doi.org/10.30997/jp.v8i1.631.
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Program superovulasi dapat dilakukan dengan Perlakuan hormonal, hormon yang sering digunakan antara lain: Preparat Progesteron dan hormon GnRH sebagai penentu estrus dalam program superovulasi. Penelitian ini bertujuan untuk menguji pengaruh implan preparat progesteron dan penggunaan hormon GnRH terhadap respon superovulasi. Penelitian ini menggunakan 10 ekor sapi Limosin yang memiliki umur 3 – 7 tahun, genetik unggul, siklus estrus normal, fertilitas tinggi, dan bebas dari penyakit reproduksi menular. Semua sapi telah dilakukan seleksi dengan cara palpasi rektal untuk menentukan status ovarium dan disinkronisasi dengan preparat progesteron dan hormon GnRH. Sapi donor dibagi dalam dua perlakuan, P1: menggunakan hormon GnRH dan P2: menggunakan preparat progesteron. Metode penyuntikan FSH secara IM, dosis menurun pagi 4 ml, 3 ml, 2 ml, 1 ml dan sore 4 ml, 3 ml, 2 ml, 1 ml. Semua perlakuan, pada penyuntikan FSH hari ke-3 pagi disertai dengan penyuntikan PGF2α 2 ml dan sore disertai cabut preparat progesteron (hanya P2), dua hari kemudian dilakukan IB dan tujuh hari setelah IB dilakukan koleksi dan evaluasi embrio. Data dianalisis dengan analisis statistik (Chi-Square). Hasil penelitian menunjukkan bahwa penggunaan preparat progesteron sebagai penentu estrus memberikan hasil yang lebih banyak pada perolehan embrio layak teransfer.KATA KUNCI: preparat progesteron, hormon gnrh, respon superovulasi, embrio layak transfer, sapi limosinUSING PREPARATE PROGESTERONE AND HORMONE PROGESTERONE GNRH IN THE DETERMINATION OF ESTRUS IN CATTLE LIMOUSINE SUPEROVULATION PROGRAM ABSTRACTSuperovulation programs to do with hormonal treatment, a hormone that is often used between others: Mixture Progesterone and hormone GnRH as a determinant of estrus in superovulation program. This study aimed to test the influence of progesterone implant preparations and the use of GnRH hormone responses superovulation. This study uses 10 cows limousines that have a lifespan of 3-7 years, genetically superior, normal estrous cycle, high fertility, and free of infectious reproductive diseases. All the cows had done the selection by means of rectal palpation to determine ovarian status and synchronized with progesterone and GnRH hormone preparations. Donor cows were divided into two treatment, P1: using the hormone GnRH and P2: using progesterone preparations. FSH IM injection method, decreased morning dose 4 ml, 3 ml, 2 ml, 1 ml and afternoon 4 ml, 3 ml, 2 ml, 1 ml. All treatments, injections of FSH on day 3 in the morning accompanied by the injection of PGF2α 2 ml and afternoon accompanied unplug progesterone preparations (only P2), two days later conducted IB and IB performed seven days after embryo collection and evaluation. Data were analyzed by statistical analysis (Chi-Square). The results showed that the use of progesterone preparations as determining estrus provide more results in the achievement of decent transfer embryos.
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Panjaitan, Budianto, Citra Chyntia Helwana, Nellita Meutia, Yusmadi Yusmadi, Tongku Nizwan Siregar, Dasrul Dasrul, and Teuku Armansyah TR. "Hubungan Kadar Progesteron pada Fase Awal Luteal dengan Kematian Embrio pada Sapi Aceh." Jurnal Agripet 19, no. 2 (October 1, 2019): 107–12. http://dx.doi.org/10.17969/agripet.v19i2.14881.
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ABSTRAK. Progesteron merupakan hormon yang berperan penting dalam proses pemeliharaan kebuntingan dan dihasilkan oleh corpus luteum. Penelitian ini bertujuan mengetahui hubungan antara kadar hormon progesteron pada fase awal luteal dengan kematian embrio pada sapi Aceh. Dalam penelitian ini digunakan empat ekor sapi betina dewasa berumur 3-5 tahun, bobot badan 150-250 kg, sehat secara klinis, dan memiliki reproduksi normal. Sapi disinkronisasi menggunakan 5 ml prostaglandin F2 alfa (PGF2α) dengan pola penyuntikan ganda berinterval 11 hari. Koleksi sampel darah untuk pengukuran konsentrasi progesteron dilakukan pada hari ke-5, 6, dan 7 pasca inseminasi. Pengukuran konsentrasi progesteron dilakukan menggunakan metode enzymelinked-immunoassay (ELISA), pemeriksaan kebuntingan dan kematian embrio menggunakan metode transrektal ultrasonografi pada hari ke-25 pasca inseminasi. Pemeriksaan diulang setiap 10 hari sampai hari ke-55 pasca inseminasi. Puncak sekresi progesteron pada sapi bunting dengan embrio yang bertahan hidup terdapat pada hari ke-7 (2,082 ng/ml), pada sapi Late Embryonic Mortality (LEM) di hari ke-5 (8,209 ng/ml) dan pada sapi tidak bunting di hari ke-7 (3,051±1,157 ng/ml). Sekresi progesteron sapi LEM pada hari ke-5 sampai dengan ke-7 cenderung menurun sedangkan pada sapi yang bertahan hidup cenderung meningkat. (Correlation between progesterone levels in early luteal phase and embryonic death in Aceh cattle) ABSTRACT. Progesterone is an important hormone that functions to maintain pregnancy and is produced by the corpus luteum. The aim of this study was to see a correlation between progesterone and the incidence of embryonic death in Aceh cattle. This study used four adult female cows, 3-5 years old, 150-250 kg body weight, clinically healthy, and have a normal reproduction. The synchronized with 5 ml prostaglandin F2 alfa hormone, and double injection pattern with 11-day intervals. The blood was collected for progesterone measurements on 5th, 6th, 7th day post artificial insemination. Measurement of progesterone concentration was carried out using an enzymelinked-immunoassay (ELISA), while pregnancy and embryo mortality was performed using the trans-rectal ultrasonography method on the 25th day after insemination. The examination was repeated every 10 days until day 55th after insemination. Progesterone secretion peaks in pregnant cows were on day 7th (2.082 ng/ml), in cattle Late Embryonic Mortality (LEM) on day 5th (8.209 ng/ml) and in cattle not pregnant on day 7th (3.051±1.157 ng/ml). The pattern of LEM progesterone secretion on days 5th to 7th tends to decrease while those that survive tend to increase.
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DeMayo, Francesco J., and John P. Lydon. "90 YEARS OF PROGESTERONE: New insights into progesterone receptor signaling in the endometrium required for embryo implantation." Journal of Molecular Endocrinology 65, no. 1 (July 2020): T1—T14. http://dx.doi.org/10.1530/jme-19-0212.
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Progesterone’s ability to maintain pregnancy in eutherian mammals highlighted this steroid as the ‘hormone of pregnancy’. It was the unique ‘pro-gestational’ bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a functional connection between normal progesterone responses (’progestational proliferation’) of the uterus with the maintenance of pregnancy was quickly appreciated, an understanding of progesterone’s involvement in the early stages of pregnancy establishment was comparatively less well understood. With the aforementioned as historical backdrop, this review focuses on a selection of key advances in our understanding of the molecular mechanisms by which progesterone, through its nuclear receptor (the progesterone receptor), drives the development of endometrial receptivity, a transient uterine state that allows for embryo implantation and the establishment of pregnancy. Highlighted in this review are the significant contributions of advanced mouse engineering and genome-wide transcriptomic and cistromic analytics which reveal the pivotal molecular mediators and modifiers that are essential to progesterone-dependent endometrial receptivity and decidualization. With a clearer understanding of the molecular landscape that underpins uterine responsiveness to progesterone during the periimplantation period, we predict that common gynecologic morbidities due to abnormal progesterone responsiveness will be more effectively diagnosed and/or treated in the future.
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Chaudhari, Shilpa, Aparajita Mishra, Kishor Hol, and Shraddha Shastri. "Compare safety and efficacy of intramuscular progesterone versus vaginal progesterone in prevention of preterm labour." Indian Journal of Obstetrics and Gynecology Research 8, no. 4 (November 15, 2021): 541–47. http://dx.doi.org/10.18231/j.ijogr.2021.111.
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Currently preterm labour is one of the most challenging problem faced by both obstetricians and perinatologists, this episode in the course of woman’s pregnancy takes a heavy tool for perinatal mortality which accounts for approximately 50-75%. The incidence of preterm labour is estimated to be 5-10% of all pregnancies. It was a prospective randomize control study. All the cases with inclusion and exclusion criteria were selected during the study period. The subjects were randomized into two groups with group A received vaginal micronized progesteron and group B intramuscular 17a hydroxyprogesteron caproate. Total of 100 cases were included in this study. All preterm pregnancy of more than 20 weeks were considered in this study. Initial nefidipine 10 mg, 4 tablets 15 min apart was given for tocolytic activity for 48 hours. Injection bethamethasone 12 mg I.M 2 doses in a duration of 24 hours apart is given for fetal lung maturity. One group will receive weekly intramuscular 17a hydroxyprogesteron (250 mg) injection while other group will receive daily micronized vaginal progesteron suppository (200mg). Subsequently compare the safety and efficacy of intramuscular progesterone versus micronized progesterone as a maintenance therapy in preventing preterm labour and analyse maternal and fetal factors.Subsequently compared the safety and efficacy of intramuscular progesterone versus micronized progesterone as a maintenance therapy in preventing preterm labour.This analysis showed that women who randomized to progesterone prophylaxis had a significantly increase in duration of pregnancy. The mean ± SD of birthweight in Group A and Group B was 2784.2 ± 490.7 gm and 2813.9 ± 363.3 gm respectively which confirmed the positive effects of progesterone on increasing infants’ weights at birth. Authors concluded that progesterone therapy had acceptable efficacy in the prevention of preterm labor in terms of prolongation of delivery and by increasing gestational age at delivery.
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Merkis, Cecilia I., and Adriana B. Vivas. "Actividad sérica del Factor Precoz de Preñez (EPF) durante la gestación en porcinos." Revista Colombiana de Ciencias Pecuarias 15, no. 1 (July 18, 2016): 63–67. http://dx.doi.org/10.17533/udea.rccp.323789.
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Resumen Para lograr una preñez exitosa es necesario un reconocimiento inmunológico entre la madre y el feto. Tal reconocimiento se realizaría a través de señales como el Factor precoz de preñez (EPF) y de hormonas como la progesterona, que se sintetizan muy tempranamente y poseen actividad inmunosupresora. En este trabajo, se estudió el comportamiento de ambas sustancias durante toda la gestación en porcinos. Se investigó en el suero de 5 cerdas, la actividad de EPF y la concentración de progesterona en estro y en los días 3, 7, 14, 21, 28, 45, 75, 90 y 110 post-servicio. La actividad del EPF mostró un perfil bifásico. Durante el primer tercio de la gestación, en todos los casos el valor máximo de progesterona, apareció 7 días después de los valores máximos de la actividad EPF. Por el contrario, en los dos tercios restantes, los valores máximos de EPF coinciden con los valores máximos de progesterona. De los resultados obtenidos podemos concluir que el EPF sería un buen indicador de fertilización y trazador de viabilidad embrionaria. Palabras Clave: Factor Precoz de la Preñez, EPF, porcinos, preñez. Summary To achieve a successful pregnancy is necessary an immunological maternal recognition among the mother and the fetus. This recognition is realized by early embryonic signals e.g. early pregnancy factor (EPF) and progesterone. The appearance of early pregnancy factor and progesterone were studied through the pregnancy in sows. In the serum from five sows EPF activity and progesterone concentration was measured in oestrus and 3, 7, 14, 21, 28, 45, 75, 90 y 100 days post-mating. EPF activity shows a biphasic profile. During the first third of pregnancy, the highest progesterone values always followed elevated EPF activity with a delay of 7 days. During the two third last of pregnancy the highest values of progesterone were coincident with highest serum EPF activity. It is concluded that EPF is a good marker to detect successful fertilization and embryonic viability. Key words: Early Pregnancy Factor, EPF, porcine, pregnancy.
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Widi Nugroho, Setyo, Harris Istianggoro, Fabianto Santoso, David Tandian, Renindra Ananda Aman, and Eka Susanto. "Characteristics and Correlation Between Progesterone Receptors and The Use of Hormonal Contraceptive in Women with Meningioma in dr. Cipto Mangunkusumo National General Hospital." eJournal Kedokteran Indonesia 10, no. 2 (September 5, 2022): 101–6. http://dx.doi.org/10.23886/ejki.10.161.101-6.
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Meningiomas are the most common primary, intracranial and extra axial tumours, estimated for 30% of all intracranial tumors. The use of hormonal contraceptive is one of the risk factors for meningioma, but the studies still have controversial results. The purpose of this study is to describe the characteristics and to correlate between progesterone receptor and the use of hormonal contraceptive in women diagnosed with brain tumor meningioma. This is a cross-sectional study which collect data in dr. Cipto Mangunkusumo National General Hospital in the year 2017-2018. Patient data collection was obtained through the patient’s medical records, whereas the subjects are women with brain tumors meningioma who have undergone surgery. We found 72 women diagnosed with meningioma; however, only 54 subjects were included in this study. Immunohistochemistry staining were performed to all the 54 subjects and revealed that 53 subjects (98.15%) had positive progesterone receptors and only 1 subject was negative (1.85%). Of the 53 subjects with positive progesterone receptors, 48 subjects used hormonal contraceptive (90.57%), with 43 (89.58%) of them used 3 month injectable contraceptive. There is no correlation between progesterone receptors and the use of hormonal contraceptives in female patients with meningioma brain tumor (p value >0.999, Fisher Test). Keywords: meningioma, hormonal contraception, progesterone receptor. Karakteristik dan Korelasi antara Progesteron Reseptor dan Penggunaan Kontrasepsi Hormonal pada Perempuan dengan Meningioma di RSUPN Dr. Cipto Mangunkusumo Abstrak Meningioma adalah tumor intrakranial ekstraaksial primer terbanyak dengan perkiraan 30% dari seluruh tumor intrakranial. Penggunaan kontrasepsi hormonal diduga menjadi salah satu faktor risiko meningioma, namun hasil penelitian masih kontroversial. Tujuan penelitian ini adalah mengetahui karakteristik dan korelasi antara progesteron reseptor dan penggunaan kontrasepsi hormonal pada perempuan dengan meningioma. Studi potong lintang ini menggunakan data rekam medis RSUPN dr. Cipto Mangunkusumo pada tahun 2017-2018. Data pasien dikumpuikan melalui rekam medis dimana subyek adalah pasien meningioma intrakranial yang dilakukan operasi. Terdapat 72 perempuan yang didiagnosis meningioma, namun data yang dapat dianalisis adalah 54 subyek. Hasil pewarnaan imunohistokimia didapatkan 53 subyek (98,15%) memiliki reseptor progesteron positif. Dari kelompok reseptor progesteron yang positif, 48 subyek (90,57%) menggunakan kontrasepsi hormonal dengan mayoritas (89,58%) menggunakan kontrasepsi injeksi 3 bulan. Tidak didapatkan korelasi antara reseptor progesteron dengan penggunaan kontrasepsi hormonal pada perempuan dengan meningioma (nilai p >0,999, Uji Fisher). Kata kunci: meningioma, kontrasepsi hormonal, reseptor progesteron
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&NA;. "Progesterone see Estrogen/progesterone." Reactions Weekly &NA;, no. 375 (November 1991): 12. http://dx.doi.org/10.2165/00128415-199103750-00071.
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&NA;. "Progesterone see Estrogen/progesterone." Reactions Weekly &NA;, no. 287 (February 1990): 7. http://dx.doi.org/10.2165/00128415-199002870-00025.
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Jerat, Sandra, and Susan Kaufman. "Effect of pregnancy and steroid hormones on plasma adrenomedullin levels in the rat." Canadian Journal of Physiology and Pharmacology 76, no. 4 (April 1, 1998): 463–66. http://dx.doi.org/10.1139/y98-113.
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Pregnancy is characterized by volumeexpansion and vasodilation. We investigated whether thehypotensive peptide adrenomedullin (ADM) might be a significantfactor in the cardiovascular adaptation to pregnancy. Rats wereprepared with indwelling cannulae. Plasma ADM levels weremeasured by RIA before mating, at 7, 14, and 21 days ofpregnancy, and at 7 days postpartum. We also investigated theeffects on plasma ADM levels of administering estrogen,progesterone, and the metabolite of progesterone3-OH-5-pregnan-20-one(3-OH-DHP); this last steroid has been implicated inaltering reflex control of blood pressure and volume duringpregnancy. Plasma ADM levels increased progressively duringpregnancy from 123 ± 27 pg/mL in virgin animals to 404 ± 50 pg/mLat 21 days of pregnancy. The levels returned to pre-pregnancyvalues postpartum.3-OH-DHP caused a significant rise in plasma ADM levels,whereas neither estrogen nor progesterone had any effect. Wesuggest that ADM may be an important contributing factor to thevasodilatation associated with normal pregnancy. Activemetabolites of progesterone, rather than progesterone itself, maybe at least partially responsible for stimulating the release ofADM.Key words: progesterone, estrogen,pregnanolone, cardiovascular system, nitric oxide.
Dissertations / Theses on the topic "Progesterone"
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Dias, Carolina Castilho [UNESP]. "Avaliação dos efeitos da concentração de progesterona nas respostas ao protocolo de sincronização da ovulação em novilhas nelore cíclicas." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/98220.
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O objetivo deste experimento foi avaliar a influência da concentração sérica de progesterona ([P4]) nos dias (d) 0 e/ou d7 do protocolo de sincronização da ovulação e da reutilização de dispositivo intravaginal de progesterona (CIDR) nos resultados a IATF em novilhas Nelore ciclando (n=398). O protocolo utilizado foi: d0-CIDR [sem utilização prévia (1ºuso), previamente utilizados por 9d (2ºuso) ou 18d (3ºuso)]+BE(2mg)+amostra de sangue para dosagem [P4], d7-PGF2(12,5mg)+amostra de sangue para dosagem [P4], d9-retirada do CIDR®+ECP(1mg), d11-IATF+mensuração do Fol, d13-avaliação da ovulação e d41-diagnóstico de gestação. Variáveis contínuas foram analizadas pelo PROC-GLM e binomiais pelo PROC-LOGISTIC do SAS. Foi considerada diferença estatística P<0,05 e tendência P<0,1. A [P4d0] influenciou de forma positiva Fol, concepção e prenhez. A [P4d7] não influenciou os parâmetros avaliados. O Fol, foi menor para 1uso (10,10,19mm) do que 3uso (11,00,21mm) e 2uso (10,60,20mm) não diferiu dos demais. A taxa de sincronização das classes de Fol diferiram entre si (Classe1:Fol<8,5, 28,2%, Classe2:8,5-10,0, 62,5%, Classe3:>10mm, 92,2%. A taxa de concepção das classes de Fol foi avaliada de acordo com o número de utilizações do CIDR no 1º e 2º usos as classes 1 e 2 tiveram menor concepção do que a Classe3, mas no 3ºuso as classes tiveram concepção similar (Classe1, 9,1%, 0%, 40,0%, Classe2: 24,0%, 21,7%, 54,5% Classe3, 52,4%, 48,9%, 53,8%, 1, 2 e 3usos respectivamente). A taxa de concepção, tendeu a ser maior com 3uso (53,2%) que 1ºuso (37,2%) e 2uso (37,8%). A taxa de prenhez, foi maior com 3ºuso (35,5%) que 1uso (20,5%) e 2uso (22,7%).
The aim of this study was to evaluate if progesterone concentrations [P4] on d0 and/or d7 of a protocol and if reutilization of intravaginal progesterone devices (CIDR) could affect FTAI success in Nellore cycling heifers. Heifers (n=398) received the protocol: d0: CIDR (with no previous use (1stuse), previously used for 9d (2nduse) or previously used for 18d (3rduse)) + EB(2mg) + blood samples to determine [P4d0], d7: PGF2 + blood sample to determine [P4d0], d9: CIDR® withdraw + ECP(1mg), D11: FTAI + largest follicle diameter measurement (Fol), D13: check ovulation and D41: pregnancy diagnoses. Continuous variables were analyzed by PROC-GLM and binomial by PROC-LOGISTIC of SAS. Statistical difference was considered with P<0,05 e tendency P<0,1. The [P4d0] positively influenced Fol, conception and pregnancy rates. The CIDR number of uses influenced [P4d7] (1stuse 2.4±1.1; 2nduse 2.0±1.0 and 3rduse 1.7±1.1ng/ml), but [P4d7] didn’t influence studied parameters. The Fol, was smaller on 1stuse (10,10,19mm) compared to 3rduse (11,00,21mm) and 2nduse (10,60,20mm) didn’t differ from others. Synchronization of Fol classes differed (Class1:Fol<8.5, 28,2%, Class2:8.5-10.0, 62.5%, Class3:>10mm, 92,2%. Conception of Fol classes were evaluated by CIDR number of uses. On 1st and 2nduse classes1 and 2 had lower conception compared to class3, but on 3rduse classes conceptions were similar (Class1, 9.1%, 0%, 40.0%, Class2: 24.0%, 21.7%, 54.5% Class3, 52.4%, 48.9%, 53.8%, 1st, 2nd and 3rduse, respectively). Conception tended to be higher on 3rduse (53.2%) compared to 1stuse (37.2%) and 2nduse (37.8%). Overall pregnancy was higher on 3rduse (35.5%) compared to 1stuse (20.5%) and 2nduse (22.7%).
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Peres, Rogério Fonseca Guimarães [UNESP]. "Efeito da concentração pré e pós-ovulatória de progesterona em protocolos de IATF em fêmeas nelore." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/96640.
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Universidade Estadual Paulista (UNESP)
O objetivo desses experimentos foi avaliar os efeitos da concentração de progesterona pré e pós-ovulação em fêmeas Nelore submetidas ao protocolo: D0-benzoato de estradiol (2,0mg, Estrogin®) + CIDR®; D9-retirada do dispositivo + cipionato de estradiol (0,5mg, ECP®) + dinoprost trometamina (PGF2α, 12,5mg, Lutalyse®); D11- IATF. No Exp.1, 1.153 novilhas Nelore cíclicas foram divididas aleatoriamente para receber CIDR® sem utilização prévia ou utilizados previamente por 18 dias e 0, 200 ou 300UI de eCG (Folligon®) no D9. No Exp.2, 702 vacas Nelore solteiras foram divididas para receber aplicação de PGF2α no D7 ou D9 e 0 ou 300 UI de eCG no D9. Nestes experimentos o diâmetro do maior folículo (ØFD) foi avaliado no D11. Amostras de sangue para dosagem de P4 foram colhidas no D9 e D18 (7d pós-IATF). No Exp.3, 1.332 vacas paridas foram avaliadas no D7 quanto à presença de CL, sendo divididas para receber PGF2α no D7 ou D9. Amostras de sangue foram colhidas no D9. O diagnóstico de gestação foi realizado no D41. Variáveis contínuas foram avaliadas pelo PROC GLM e binomiais pelo PROC LOGISTIC. Considerou-se efeito significativo quando P<0,05 e tendência quando P<0,1. No Exp.1, as novilhas tratadas com CIDR® sem utilização prévia apresentaram maior [P4D9] (3,06±0,09 vs. 2,53±0,09 ng/ml). A [P4D9] afetou negativamente o ØFD. Novilhas que não receberam eCG apresentaram menor ØFD (0UI: 11,5±0,1a; 200UI: 11,9±0,1b; 300UI: 12,0±0,1bmm). O ØFD afetou positivamente a [P4D18]. Houve efeito de dose de eCG na [P4D18] (0UI: 2,77±0,11a; 200UI: 3,18±0,11b; 300UI: 4,87±0,11cng/ml) e na taxa de sincronização [TS; 0UI: 83,8%(337/402)a; 200UI:88,5%(339/383)ab; 300UI: 94,3%(347/368)b]. A [P4D9] tendeu a afetar negativamente e o ØFD influenciou positivamente a TS. Houve interação entre eCG e [P4D9] na taxa de...
The aim of this trial was to evaluate the effect of pre- and post-ovulatory progesterone concentration in Nellore cattle treated with the protocol: D0-estradiol benzoate (2.0mg, Estrogin®) + CIDR®; D9–CIDR® withdrawal + of estradiol cypionate (0.5mg, ECP®) + dinoprost trometamine (12.5mg, Lutalyse®); D11-TAI. In Exp.1, 1,153 cycling Nellore heifers were randomly assigned to receive on D0 either a non-previously used or a 18d-previously CIDR® and 0, 200UI or 300UI of eCG (Folligon®) on D9. In Exp.2, 702 non-lactating Nellore cows were assigned to receive PGF2α treatment either on D7 or D9 and 0 or 300 IU of eCG on D9. On these experiments, the diameter of the largest follicle (ØFD) was measured on D11. Blood samples were collected on D9 and D18 (seven days after TAI) to evaluate serum progesterone concentrations. In Exp.3, 1,332 suckled Nellore cows were evaluated on D7 for luteal tissue presence. Cows were assigned to receive PGF2α either on D7 or D9. Blood samples were collected on D9. Pregnancy diagnosis was performed on D41. Continuous variables were evaluated by PROC GLM and binary by PROC LOGISTIC. Significant differences were considered when P<0.05 and tendencies when P<0.1. In Exp.1, heifers treated with non-previously used CIDR® had greater [P4D9] (3.06±0.09 vs. 2.53±0.09 ng/ml). The [P4D9] negatively affected the ØFD. There was effect of eCG dosage on ØFD (0IU: 11.5±0.1a; 200IU: 11.9±0.1b; 300IU: 12.0±0.1bmm). The ØFD positively affected the [P4D18]. The eCG dosage influenced the [P4D18] (0UI: 2.77±0.11a; 200UI: 3.18±0.11b; 300UI: 4.87±0.11cng/ml). Treatment with eCG affected synchronization rate [SR; 0IU: 83.8% (337/402)a; 200IU: 88.5% (339/383)ab; 300IU: 94.3% (347/368)b]. The [P4D9] tended to negatively affect, and the ØFD positively affected the SR. There was interaction between eCG and [P4D9] on conception...
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Conceição, Juliana Costa da [UNESP]. "Dinâmica ovariana e concentrações plasmática de progesterona durante o ciclo estral de jumenta (Equus asimus)." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/98270.
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conceicao_jc_me_botfmvz.pdf: 117039 bytes, checksum: 5aad27c64434953f5c89d1c49e965971 (MD5)A atividade folicular ovariana foi estudada utilizando-se a ultra-sonografia e a concentração plasmática de progesterona (P4) ao longo de 10 ciclos estrais em jumentas da raça Marchador Brasileira. Diariamente exames ultra-sonográfico foram realizados e os dados compilados foram estudados retrospectivamente, baseando-se na identificação diária de cada folículo. Amostras de sangue foram colhidas diariamente a partir da ovulação (D0) até a ovulação subseqüente. Os folículos com diâmetros 11 mm foram mensurados e o diâmetro médio foi registrado diariamente em um mapa representativo dos ovários realizando uma análise retrospectiva dos dados, permitindo a construção da dinâmica de crescimento folicular. Uma e duas ondas foliculares maiores foram detectadas em seis (60%) e quatro (40%) dos dez ciclos estrais estudados, respectivamente. A emergência da onda primária e divergência folicular para ciclos com uma onda maior foram 10,2±0,75 e 14±0,81 e para os ciclos com duas ondas maiores 9±2 e 14,0±1,15 dias pós-ovulação. O diâmetro máximo do folículo dominante nos ciclos com uma e duas ondas foliculares foram 37,2±3,35 mm e 37,3±1,1mm, respectivamente. A duração média do intervalo interovulatório foi de 23±1,79 e 22,3±1,26 dias nos ciclos com uma ou duas ondas maiores. O diâmetro máximo do folículo dominante foi ligeiramente menor nos casos de ovulações duplas, em comparação às ovulações únicas (p>0,05). Os corpos lúteos formados a partir de ovulações simples ou duplas apresentaram diâmetro de 26,2 4,4 e 22,12,7mm, respectivamente, representando 66,1% e 64,1% do tamanho do folículo pré-ovulatório. A presença de dois corpos lúteos nos ovários das jumentas que apresentaram ovulações duplas, não refletiu em aumento significativo da concentração de progesterona.
The ovarian activity was accessed by ultrasound and progesterone plasma concentrations (P4) throughout 10 estrous cycles from Jennies (Marchador Brasileira). Daily ultrasound examinations were performed and the dada was retrospectively studied based on daily identification of each follicle detected. Blood samples were collected every 24 hours from ovulation (D0) until the next identified ovulation. The follicles measuring 11mm were detected and their mean diameter was registered daily using an ovarian map and permitting a retrospective evaluation of the dada, which represented the follicular growth dynamics. One and two major follicular waves were detected in six (60%) and four ( 40%) cycles respectively from ten estrous cycles in the present study. The primary wave emergency and follicle deviation from the cycles observed during the present study with one major follicular wave occurred at day 10.2 0.75 and at day14.1 0.81 and for cycles with two major waves, those events occurred at 9 2 and 14.0 1.15 days after ovulation. The maximum diameter of the dominant follicle at the cycles with one and two follicular waves were 37.2 3.35 mm and 37.3 1.1 respectively. The mean intervals from two ovulations were 23 1.79 and 22.3 1.26 days when observed in cycles with one and two major follicular waves. The maximum diameter of the dominant follicle was slightly smaller when double ovulations were observed if compared with the single ovulations (p>0.05). The corpora lutea formed from single ovulations or double ovulations presented a mean diameter of 26.2 4.4 and 22.1 2.7 mm, respectively, which represented 66.1% and 64.1% of the preovulatory follicle diameter. The presence of two Cls from double ovulations was not reflected by a significant increase on progesterone concentrations.
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Torres, Chavez Karla Elena 1978. "Influencia do sexo e dos hormonios sexuais na inflamação induzida pela administração de formalina na articulação teporomandibular de ratos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290574.
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Orientador: Claudia Herrera TambeliDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: A alta prevalência das condições dolorosas e desordens inflamatórias da articulação temporomandibular e de doenças inflamatórias no sexo feminino sugere a participação dos hormônios sexuais na modulação da dor e da resposta inflamatória da articulação temporomandibular. Estudos prévios sugerem que os altos níveis do estradiol durante o ciclo estral e a administração de estradiol ou progesterona em ratas ovariectomizadas ou testosterona em ratos orquidectomizados diminui a nocicepção induzida pela injeção de formalina (1,5%) na articulação temporomandibular. O mecanismo pelo qual esses hormônios reduzem a nocicepção da articulação temporomandibular ainda não é conhecido, mas poderia ser delimitado por uma atividade antiinflamatória. Diante disso, o objetivo deste trabalho foi avaliar o efeito do sexo e dos hormônios sexuais na inflamação induzida pela injeção de formalina na articulação temporomandibular. Para avaliar a inflamação na articulação temporomandibular, nós mensuramos o extravasamento plasmático e a migração de leucócitos polimorfonucleares (neutrófilos). A formalina, agente nociceptivo e inflamatório, induziu extravasamento plasmático e migração de neutrófilos significativamente menor em fêmeas em proestro que em fêmeas em diestro e machos. O extravasamento plasmático e a migração leucocitária em fêmeas ovariectomizadas foi similar ao de fêmeas sham-ovariectomizadas em diestro e significativamente maior que o de fêmeas sham-ovariectomizadas em proestro. A administração de estradiol, mas não de progesterona em fêmeas ovariectomizadas diminuiu significativamente o extravasamento plasmático e a migração leucocitária induzida pela injeção de formalina na articulação temporomandibular. A orquidectomia não afetou o extravasamento plasmático e a migração leucocitária, no entanto, administração de testosterona em machos orquidectomizados os reduziu significativamente. Dessa forma, pode-se concluir que o estradiol e a testosterona exercem um pronunciado efeito antiinflamatório na articulação temporomandibular, sugerindo que este efeito pode mediar, ao menos em parte, o efeito antinociceptivo destes hormônios na articulação temporomandibular
Abstract: The greater prevalence of pain conditions in temporomandibular joint and inflammatory diseases in female suggests the involvement of sex hormones in temporomandibular joint pain and inflammation. Previous studies suggest that the high estradiol level during the rat estrous cycle and the administration of estradiol or progesterone in ovariectomized female or testosterone in orchiectomized male rats decrease formalin-induced temporomandibular joint nociception. The mechanism by which sex hormones decrease temporomandibular joint nociception is unknown, however could be mediated by decreasing temporomandibular joint inflammation. For that reason, the aim of this study was to evaluate the effect of sex and sex hormones on formalin-induced temporomandibular joint inflammation. To measure temporomandibular joint inflammation, we evaluated plasma extravasation and neutrophil migration. Formalin induced significant lower temporomandibular joint plasma extravasation and neutrophil migration in proestrus females than in males and in diestrus females. Formalin-induced temporomandibular joint plasma extravasation and neutrophil migration in ovariectomized females were similar to those of sham-operated diestrus females and significantly higher than those of sham-operated proestrus females. Estradiol but not progesterone administration in ovariectomized females significantly reduced formalin-induced temporomandibular joint plasma extravasation and neutrophil migration. Formalin-induced temporomandibular joint plasma extravasation and neutrophil migration were not affected by orchiectomy, while testosterone administration in orchiectomized males significantly decreased them. Taken together, these findings demonstrate a pronounced anti-inflammatory effect of estradiol and testosterone in temporomandibular joint and suggest that this effect may mediate, at least in part, the antinociceptive effect of these hormones on the temporomandibular joint
Mestrado
Fisiologia Oral
Mestre em Odontologia
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Zhu, Xiaoyan. "Progesterone in Stroke Cerebroprotection : Metabolites, Target Cells, and Role of Neural Progesterone Receptors (PR)." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS449.
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L’accident vasculaire cérébral (AVC) déclenche une cascade de changements qui conduisent à la mort cellulaire mais aussi des processus endogènes de protection en réponse à l'ischémie. La compréhension de ces processus est très importante pour le développement d’agents neuro-protecteurs potentiels qui peuvent être seulement des amplificateurs des processus endogènes. Le traitement par la progestérone est neuro-protecteur dans des modèles expérimentaux d’occlusion de l'artère cérébrale moyenne (MCAO). Cependant, des niveaux endogènes significatifs de progestérone sont mesurables dans le cerveau de souris mâles et femelles.Le but de notre travail était d'étudier: 1) les effets de l’ischémie sur les niveaux endogènes des stéroïdes et le rôle des récepteurs de la progestérone (PR) à la phase aiguë après ischémie chez les souris jeunes adultes et âgées des deux sexes; 2) la base cellulaire de la neuroprotection par la progestérone après ischémie et le rôle de PR neural. Nous avons utilisé un modèle d’ischémie expérimentale (MCAO); une lignée transgénique de souris (PRNesCre) dans laquelle l’expression de PR a été sélectivement invalidée dans les cellules neurales; la chromatographie en phase gazeuse-spectrométrie de masse en tandem (GC-MS/MS); et des analyses histologiques, comportementales, et d’immunofluorescence.Dans la première partie, nous avons montré que dans le cerveau de souris mâles la progestérone est principalement convertie en 5a-dihydroprogestérone (5a-DHP), qui est un agoniste naturel de PR. Après MCAO, les niveaux de progestérone et de 5a-DHP cérébrales augment chez les mâles, mais pas chez les femelles. En revanche, les femelles peuvent utiliser l’inter-conversion de la 20a-dihydroprogestérone et de la progestérone pour réguler la disponibilité des pregnanes actifs au niveau de PR. De plus, les souris PRNesCre, mâles et femelles jeunes adultes et âgées, ont des infarctus plus grands et des déficits sensori-moteurs plus importants ainsi qu’une diminution de la densité des neurones et de la microglie activée comparativement aux souris témoins PRloxP/loxP. En outre, nos résultats ont révélé des différences liées au sexe chez les souris jeunes, mais pas chez les souris âgées. Dans la deuxième partie de l'étude, nous avons montré que, chez les souris mâles PRloxP/loxP, le traitement par la progestérone améliore la récupération fonctionnelle et réduit le volume de l'infarctus. Dans le péri-infarctus, la progestérone augmente la densité des neurones, des oligodendrocytes et de leurs précurseurs, et diminue la densité des astrocytes et de la microglie activée, et l'expression de l’aquaporine 4. Ces effets de la progestérone n’ont pas été observés chez les souris PRNesCre.Nos résultats montrent 1) l'importance des pregnanes endogènes et du PR neural pour la protection cérébrale à la phase aiguë précoce après une ischémie; 2) que le traitement par la progestérone chez les souris mâles après ischémie a des effets neuro-protecteurs, pro-myélinisants et anti-inflammatoires et que PR neural est requis pour la médiation de ces effets. Ces données suggèrent fortement que les ligands de PR ou des agents ciblant leur signalisation en aval pourraient être développés pour la neuro-protection après un AVCIschemic stroke initiates a cascade of changes that lead to cell death and also coordinates endogenous processes that counteract the nocuous consequences of ischemia. Understanding these processes is very important for the development of potential neuroprotectants which can be just boosters of endogenous processes. Treatment with exogenous progesterone is neuroprotective after middle cerebral artery occlusion (MCAO). However, the male and female brains contain significant amounts of endogenous progesterone.The aim of our work was to study: 1) the effects of MCAO on the endogenous levels of steroids and the role of neural progesterone receptors (PR) at the acute phase after stoke in young and aging mice of both sexes; 2) the cellular basis of the neuroprotection by progesterone following stroke and the role of neural PR. We used an in vivo model of MCAO; a transgenic mice line (PRNesCre) selectively lacking the expression of PR in neural cells; gas chromatography-tandem mass spectrometry (GC-MS/MS); and histological, behavioral, and immunofluorescence analyses.In the first part of the study, we showed that in the male mouse brain, progesterone is mainly converted to 5a-dihydroprogesterone (5a-DHP), which is a natural PR agonist ligand. After MCAO, brain levels of progesterone and 5a-DHP are rapidly upregulated in males but not in females. In contrast, females may use the interconversion of 20a-dihydroprogesterone and progesterone for regulating the availability of PR-active pregnanes. Moreover, young and aging male and female PRNesCre mice exhibited increased infarcts, severe sensorimotor deficits, and decreased densities of neurons and microglia comparatively to age-matched control mice PRloxP/loxP. In addition, our results revealed sex differences in stroke outcomes in young but not in aging mice. In the second part of the study, we showed that, in male PRloxP/loxP mice, progesterone improved sensorimotor outcomes and reduced infarct volumes. In the peri-infarct, progesterone increased the densities of neurons, oligodendrocytes and their precursors, decreased the densities of activated astrocytes and microglia, and the expression of the aquaporin 4. These beneficial effects of progesterone were not observed in PRNesCre mice.Our findings 1) uncover the importance of endogenous pregnanes and neural PR for the cerebroprotection at the early acute phase after stroke; 2) show that progesterone treatment in male mice has neuro-protectant, pro-myelinating and anti-inflammatory effects after MCAO and that neural PR is required for the mediation of these effects. These data strongly suggest that ligands of PR or agents targeting their downstream signaling could be developed for neuroprotection after stroke
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Santos, Rafael Dalbosco dos. "O impacto do diabetes Mellitus do tipo 1 sobre a ação da resposta proliferativa estimulada pela progesterona no ambiente uterino de camundongos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-18042016-101410/.
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A proliferação celular mediada pela progesterona (P4) é essencial para a funcão uterina. Dessa forma, alterações nesse processo podem comprometer a reprodução. O diabetes do tipo 1 (DM1) está associado a diversos distúrbios reprodutivos. No entanto, o impacto do DM1 sobre a ação da P4 no ambiente uterino ainda não é conhecido. Para isso, utilizamos fêmeas de camundongo DM1 induzidas por aloxana, submetidas à ovarectomia (OVX) e reposição por P4. Verificamos por meio de histomorfometria e imunohistoquímica (PCNA) uma diminuição da área de estroma uterino e do índice de proliferação. As quantificações proteícas por Western blot monstraram um aumento do PR-A nas fêmeas diabéticas OVX e nas tratadas pela P4. Ressalta-se que as fêmeas DM1 tratados pela P4 não apresentaram a mesma expressão do RNAm para o fator de crescimento Hoxa-10. Houve também um aumento do RNAm da p27 nas fêmeas DM1 não tratadas, visto por qPCR. Nossos resultados demonstraram que o DM1 interfere negativamente na resposta proliferativa promovida pela P4. Contribuindo para compreensão dos mecanismos biológicos pelos quais o diabetes compromete as funções reprodutivas.Progesterone (P4)-mediated cell proliferation is essential for uterine function. Therefore, alteration in this process could compromise reproduction. The type 1 diabetes (DM1) relates to several reproductive disturbs. However, the impact of DM1 on the P4 function is still not elucidated. Thus, we used alloxan-induced diabetic mice females subjected to ovariectomy and hormonal replacement therapy with P4. Histomorphometrical and immunohistochemistry to PCNA approaches showed a decrease of the uterine stromal area and the cell proliferation index. Protein quantification by Western blot showed increased levels of PR-A in both ovariectomized and P4-treated diabetic females. Importantly, P4 did not recovered the mRNA expression to the Hoxa-10 transcription factor in diabetic females. Additionally, qPCR analysis revealed increased level of p27 mRNA in diabetic females non-treated with P4. Together these results show that DM1 has a negative action on the P4-mediated cell proliferative response. These are new and important results to a better understand of the biological mechanisms by which diabetes affects the reproductive functions.
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Shahzamani, Afshin. "Progesterone as an anti-convulsant." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63177.pdf.
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Anderson, Laurie. "The myometrial effects of progesterone." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2203/.
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Introduction: Preterm birth is the leading cause of perinatal morbidity and mortality and rates are rising. The UK now has the highest rate of premature birth in Europe with 5.3% of overall births in Scotland occurring spontaneously before 37 weeks gestation (1, 2) .Preterm babies have higher rates of perinatal mortality and morbidity and those that survive are at risk of multiple conditions including respiratory distress syndrome, central nervous system abnormalities, necrotising enterocolitis and sepsis. The mechanisms of preterm birth are poorly understood. Preterm birth can be spontaneous or induced and spontaneous preterm labour has multiple aetiologies. Current evidence suggests that prolonged treatment with progesterone and 17 α-hydroxyprogesterone caproate (17OHPC) may reduce the incidence of premature delivery in high risk patients with a history of spontaneous preterm birth (3) or with a short cervix. However, progesterone is not uniformly effective in preventing preterm labour and at present its principal mode of action on myometrium is unknown. I aimed to determine some of the specific mechanisms of action of progesterone. Aims: I hypothesised that progesterone has a direct inhibitory effect on spontaneous myometrial contractility, induces increased sensitivity to tocolytic agents and decreases sensitivity to contractile agonists such as oxytocin. I also hypothesised that progesterone has inhibitory effects on endogenous uterine stimulants, stimulatory effects on endogenous uterine relaxants, induces upregulation of endogenous receptors that inhibit uterine contractions and inhibits contraction associated proteins both in vitro and in vivo. Methods: I recruited women already enrolled in the STOPPIT (a double blind randomised placebo controlled study of progesterone for the prevention of preterm birth in twins) who were given vaginal progesterone, or placebo and who were scheduled for caesarean section. I also recruited women with healthy twin or singleton pregnancies undergoing elective caesarean section. Myometrial biopsies were obtained from the upper border of the lower uterine segment incision during caesarean section. Samples were divided and used for contractility measurements, or subsequent mRNA, protein and immunohistochemical analysis. Myometrial strips were cut and suspended under resting tension within organ baths. Concentration-response curves were carried out in response to oxytocin, levcromakalim, nifedipine and ritodrine to ascertain any reduction in effect by progesterone on oxytocics or enhancement of tocolytic effects. I also carried out concentration-response curves to progesterone alone and in the presence of potassium channel blocking agents. I then assessed ex vivo, the inherent contractility of the placebo versus progesterone groups from myometrium sampled from the STOPPIT cohort of patients. I carried out cell culture experiments on myometrium from healthy singleton women who were not in labour at the time of sampling. Myometrial explants were placed in cell culture medium, cultured for 1, 4 and 24 hours, and the supernatants were then analysed using Bio-Plex array technology to ascertain cytokine release. I selected time points and concentrations conditions to incubate myometrial tissue using progesterone and 17OHPC and was able to assess cytokine release. The myometrial explants were used for subsequent molecular studies. I performed real time-polymerase chain reaction (RT-PCR) (Abi,Taqman) to quantitate endogenous inhibitors of uterine contractility (cGRPR, EP2,NOS), cytokines (interleukins- IL6, IL8, IL1β), uterine stimulants COX-2 and gap junction components ( connexin 26 and connexin 43) expressed relative to housekeeping gene 18s. Lastly, I analysed the STOPPIT cohort of myometrial samples for to determine the in vivo effect of progesterone. We carried out RT-PCR (Abi,Taqman) to quantitate endogenous inhibitors of uterine contractility (cGRPR, EP2,NOS, PGDH), cytokines (IL6, IL8, IL1β) and gap junction components (connexin 26 and 43).I performed immunohistochemistry, staining for localisation of pro-inflammatory cytokines. I then carried out protein expression analysis using Western blot for contraction associate protein, connexin 43. The project was approved by North Glasgow University Hospitals Research Ethics Committee ref no. 05/S0705/18. All patients gave written informed consent to participate. Results: I found that progesterone, exerted consistent, rapid and sustained inhibition of the amplitude of spontaneous myometrial contractions in vitro at high concentrations however, this affect was not achieved through the principal potassium channels. Levcromakalim, a KATP channel opener, produced a concentration-dependent inhibition of the amplitude and frequency of spontaneous contractions. These effects were antagonised by the KATP channel blocker, glibenclamide. In contrast, glibenclamide had no effect on the progesterone-induced inhibition of myometrial contractility. Charybdotoxin 10 nM (which blocks IKCa, BKCa and Kv channels), iberiotoxin 100 nM (which blocks BKCa channels) and apamin 100 nM (which blocks SKCa channels) failed to affect the ability of progesterone to inhibit myometrial contractility. In contrast, 17OHPC did not exert any inhibitory effect on myometrial activity in vitro. Results indicated, at the selected pharmacological doses used in vitro that progesterone did not increase sensitivity to tocolytic agents tested. There was no decrease in sensitivity to the uterotonin oxytocin. Lastly, from our STOPPIT patient cohort I demonstrated no difference between the progesterone and placebo groups in either spontaneous contractility, response to tocolytics as above or response to oxytocin. One main conclusion of this arm of the study is that in vivo progesterone therapy to prevent pre-term labour does not appear to modify contractility ex vivo. I demonstrated that administration of progesterone but not 17OHPC for up to 24 hours in vitro does not appear to modify mRNA expression of uterine stimulants such as cytokines, COX-2 or endogenous uterine relaxants such as NOS and PGDH. Progesterone but not 17OHPC inhibited production of gap junction component connexin 43. This modification of contraction associated protein is in agreement with other literature presented on human myometrial data in vitro (4) . I used STOPPIT patients as a potential example of the myometrial effects of progesterone in vivo with a placebo treated control group. Prolonged maternal administration of progesterone appeared to inhibit expression of gap junction components connexin 26 and 43 in myometrium. Connexin 43 importantly, was also modified in vitro within the progesterone treated arm. However, ex-vivo assessment of the functional impact on human myometrium does not demonstrate a long-term inhibitory impact on myometrial function with down regulation of endogenous contractile inhibitors such as eNOS and EP2. The connexins play an essential role in regulating synchronous myometrial contractions. If progesterone has been of benefit in those at risk of preterm labour with a history of spontaneous preterm birth, it is possible therefore that this is by reducing connexin expression, which prevents the development of these synchronous contractions whilst on progesterone therapy. In summary, I have demonstrated putative mechanisms by which progesterone (and its analogue 17OHPC) might prevent preterm birth. Further studies characterising these pathways might inform the design of other agents which could provide additional efficacy in preventing preterm delivery.
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Tometzki, G. B. "d1-Progesterone : A total synthesis." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374578.
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Vieira, Fernanda Victor Rodrigues [UNESP]. "Infusão intravenosa de glicose e balanço energético na expressão de enzimas hepáticas responsáveis pelo catabolismo de progesterona em bovinos." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/96632.
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vieira_fvr_me_botfmvz.pdf: 300511 bytes, checksum: e122704bc94212fa16d6f5f449d2e702 (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Universidade Estadual Paulista (UNESP)
O objetivo deste experimento foi avaliar o efeito da infusão intravenosa de glicose sobre as concentrações séricas de glicose, insulina, IGF-1, P4, expressão de RNAm de GHR1A e IGF-1, e expressão de RNAm das enzimas hepáticas CYP2C e CYP3A, responsáveis pelo catabolismo de P4 no fígado, em vacas leiteiras secas, ovariectomizadas e com dispositivo intravaginal de P4 (CIDR) em diferentes BE. Foram utilizadas 15 vacas mestiças Holandês/Gir ovariectomizadas e secas, aleatoriamente distribuídas em um de dois tratamentos nutricionais: 1) BEN (n=7) e 2) BEP (n=8). O grupo de vacas em BEP recebeu concentrado individualmente uma vez ao dia. Durante a fase de adaptação (d-28 ao d-15,5), cada vaca recebeu um CIDR de terceiro uso, sendo que após esta fase (d-14), cada vaca recebeu um CIDR novo. No d 0, as vacas foram aleatoriamente distribuídas em crossover design contendo dois períodos de 24 horas cada (d 0 e d 1): 1) infusão intravenosa de glicose (0,5g/Kg de PV) ou 2) infusão intravenosa de salina (0,9% NaCl). Imediatamente após jejum de 12 horas, as infusões foram feitas em período de três horas. Amostras de sangue foram coletadas às -12 (início do jeum), 0 (antes da infusão), 3 e 6 horas após início da infusão através da veia coccígea em tubos tipo vacutainer. As biopsias hepáticas foram feitas às 0 e 3 horas nos dias do tratamento (d 0 e d 1). Vacas em BEN perderam mais PV e ECC em relação às vacas em BEP (-23,15 vs. 16,5 kg ± 3,9; -0,200 vs. 0,075 unidades de ECC ± 0,062, respectivamente). Vacas recebendo infusão intravenosa de glicose tiveram maiores concentrações séricas de glicose às 3 horas do início da infusão do que vacas recebendo salina. Vacas em BEN recebendo glicose tiveram maiores concentrações séricas de insulina do que vacas em BEP recebendo glicose às 3 horas pós-infusão...
The objective of this study was to evaluate the effect of intravenous glucose infusion on serum concentrations of glucose, insulin, IGF-1, progesterone (P4), mRNA expression of GHR1A, IGF-1, and mRNA expression of hepatic enzymes CYP 2C and CYP 3A responsible for the catabolism of P4 in the liver in dry cows, ovariectomized with intravaginal device P4 (CIDR) in different energy balances. Fifteen non-lactating, ovariectomized Gir × Holstein cows, and randomly assigned to: 1) negative nutrient balance (NB; n=7)) and 2) positive nutrient balance (PB; n=8). The group of cows in PB was supplemented individually once a day. For the adaptation phase (d-d-28 to 15, 5), each cow received a CIDR of the third use, and after the adaptation phase (d-14), each cow received a new CIDR. On d 0, cows within nutritional treatment were randomly assigned to receive, in a crossover design containing 2 periods of 24 h each (d0 and d1): 1) intravenous glucose infusion (0.5g/Kg of BW), or 2) intravenous saline infusion (0,9% NaCl). Immediately after fasting for 12 hours, infusions were made over a period of three hours. Blood samples were collected at -12 (beginning of fasting), 0 (before infusion), 3 and 6 hours after start of infusion via the coccygeal vein in vacutainer tubes without anticoagulant type. The liver biopsies were performed at 0 and 3 hours in the day of treatment (d 0 and d 1). NB cows lost more BW and BCS than PB cows (-23.15 vs. 16.5 kg ± 3.9, vs. -0.200. 0.075 ± 0.062 BCS units, respectively). Cows receiving intravenous infusion of glucose had higher serum concentrations of glucose to 3 hours for the start of infusion than cows receiving saline. NB cows receiving glucose had higher serum concentrations of insulin than PB cows receiving glucose, however PB cows receiving glucose had higher serum concentrations... (Complete abstract click electronic access below)
Books on the topic "Progesterone"
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Szekeres-Bartho, Julia. Immunosuppression by progesterone in pregnancy. Boca Raton: CRC Press, 1992.
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Shahzamani, Afshin. Progesterone as an anti-convulsant. Ottawa: National Library of Canada, 2001.
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Lobo, Rogerio A. Progesterone in hormonal replacement therapy. Carnforth, Lancs: Parthenon, 1992.
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R, Lee John. Natural progesterone: The multiple roles of a remarkable hormone. Sebastopol, CA: BLL Pub., 1995.
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de, Ziegler D., and Bulletti Carlo, eds. Progesterone: A natural, life supporting hormone. Oxford: Oxford University Press, 2000.
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Ganten, Detlev, and Donald Pfaff, eds. Actions of Progesterone on the Brain. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-69728-9.
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1941-, Ganten D., Pfaff Donald W. 1939-, and Kato Junzo, eds. Actions of progesterone on the brain. Berlin: Springer-Verlag, 1985.
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Dalton, Katharina. Guide to progesterone for postnatal depression. [London]: The Author, 1990.
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M, Beier Henning, and Spitz Irving M, eds. Progesterone antagonists in reproductive medicine and oncology. Oxford: Oxford University Press, 1994.
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S, Fraser Ian, ed. Estrogens and progestogens in clinical practice. London: Churchill Livingstone, 1998.
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Fujimori, Keiya, Hyo Kyozuka, and Shun Yasuda. "Progesterone." In Preterm Labor and Delivery, 149–59. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-9875-9_15.
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Porcari, Irene, Mariachiara Bosco, and Stefano Uccella. "Progesterone." In Endocrine Pathology, 696. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62345-6_5326.
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Roney, James R., Goirik Gupta, and Mei Mei. "Progesterone." In Encyclopedia of Sexuality and Gender, 1–7. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-59531-3_6-1.
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Baker, Julien S., Fergal Grace, Lon Kilgore, David J. Smith, Stephen R. Norris, Andrew W. Gardner, Robert Ringseis, et al. "Progesterone." In Encyclopedia of Exercise Medicine in Health and Disease, 726. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2906.
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Prior, Nora H. "Progesterone." In Encyclopedia of Animal Cognition and Behavior, 1–7. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47829-6_485-1.
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Prior, Nora H. "Progesterone." In Encyclopedia of Animal Cognition and Behavior, 5671–77. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-55065-7_485.
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Schomburg, Dietmar, and Dörte Stephan. "Progesterone monooxygenase." In Enzyme Handbook, 755–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-57942-4_156.
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Ward, Tony Milford. "Progesterone Receptor." In Proteins and Tumour Markers May 1995, 1331. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0681-8_68.
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Chrousos, George P., Neil J. MacLusky, David D. Brandon, Masako Tomita, David M. Renquist, D. Lynn Loriaux, and Mortimer B. Lipsett. "Progesterone Resistance." In Advances in Experimental Medicine and Biology, 317–28. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5101-6_21.
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Porcari, Irene, Mariachiara Bosco, and Stefano Uccella. "Progesterone Receptor." In Endocrine Pathology, 697. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62345-6_5327.
Full textConference papers on the topic "Progesterone"
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"Progesterone and Brain Cancer." In 4th International Conference on Advances in Agricultural, Biological & Ecological Sciences. International Institute of Chemical, Biological & Environmental Engineering (IICBEE), 2016. http://dx.doi.org/10.15242/iicbe.c1216058.
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Kolesniková, Lucie, José Alonso, Iker León, Aran Insausti, and Elena Alonso. "THE SHAPE OF PROGESTERONE." In 2022 International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2022. http://dx.doi.org/10.15278/isms.2022.mi04.
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Hada, Manila, Hannah Oh, Sharon Fan, Roni T. Falk, Berta Geller, Pamela Vacek, Donald Weaver, et al. "Abstract 588: Relationship of serum progesterone and progesterone metabolites with mammographic density." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-588.
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Hada, Manila, Hannah Oh, Sharon Fan, Roni T. Falk, Berta Geller, Pamela Vacek, Donald Weaver, et al. "Abstract 588: Relationship of serum progesterone and progesterone metabolites with mammographic density." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-588.
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Prokopuk, A. I., K. V. Yurchankova, E. M. Shpadaruk, and R. M. Smolyakova. "ASSESSMENT OF HORMONAL STATUS WITH AN ESTABLISHED MOLECULAR-BIOLOGICAL PROFILE OF PATIENTS WITH BREAST CANCER OF DIFFERENT REPRODUCTIVE PERIOD." In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2021. http://dx.doi.org/10.46646/sakh-2021-2-93-96.
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In the course of the study, it was found that the luminal A subtype in patients with breast cancer is associated in 100% of cases with increased blood levels of estradiol, progesterone, and prolactin. In the postmenopausal period, the luminal B (Her-2-positive) subtype is associated with a 100% increase in the concentration of the hormones estradiol and progesterone. In patients with preserved ovarian-menstrual function, luminal B (Her-2-positive) subtype in 37.5% of cases is associated with increased estradiol content. Luminal B (Her-2-negative) subtype is associated with increased blood levels of estradiol, progesterone, and prolactin in 100% of patients. The Her-2 / neu-positive subtype is associated with decreased serum estradiol levels in 33% of patients and decreased progesterone levels in 83% of patients. In patients with a triple-negative subtype, an increased content of estradiol and progesterone in the blood was diagnosed in 100% of patients.
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Zia, Asif I., A. R. Mohd Syaifudin, S. C. Mukhopadhyay, P. L. Yu, I. H. Al-Bahadly, Jurgen Kosel, and Chinthaka Gooneratne. "Sensor and instrumentation for progesterone detection." In 2012 IEEE International Instrumentation and Measurement Technology Conference (I2MTC). IEEE, 2012. http://dx.doi.org/10.1109/i2mtc.2012.6229289.
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"Does Progesterone Influence Hela Cell Proliferation?" In 2016 International Conference on Biological and Environmental Science. Universal Researchers, 2016. http://dx.doi.org/10.17758/ur.u0616232.
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Zhang, Guangqiu, Shujuan Li, and Haiying Yang. "Microbial conversion of progesterone with Aspergillus sp." In 2015 International Conference on Materials, Environmental and Biological Engineering. Paris, France: Atlantis Press, 2015. http://dx.doi.org/10.2991/mebe-15.2015.211.
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Amicis, F. De, F. Montalto, C. Chiodo, D. Naimo, L. Mauro, S. Aquila, M. Lanzino, and S. Andò. "PO-154 Progesterone through progesterone receptor-B inhibits invasion of human breast cancer cells by targeting cytoplasmic cyclin D1." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.194.
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Vares, Guillaume, Sei Sai, Bing Wang, Akira Fujimori, Mitsuru Nenoi, and Tetsuo Nakajima. "Abstract 2246: Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2246.
Full textReports on the topic "Progesterone"
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Britt, Jack, Miriam Rosenberg, Steven Washburn, and Moshe Kaim. Development and Evaluation of a Method of Hormonal Treatment to Increase Fertility in Dairy Cows. United States Department of Agriculture, December 1995. http://dx.doi.org/10.32747/1995.7612833.bard.
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The objectives were: 1) to develop a practical method for improving conception rates of dairy cows by administering progesterone during the critical period of the luteal phase prior to first insemination, 2) to determine which cows respond best to such a progesterone treatment, and 3) to determine physiological changes that are associated with this treatment. Experiment 1, conducted in the US and Israel, tested three treatment protocols. Holstein cows: 1) served as controls, 2) received two injections of prostaglanding F2a (PGF) 14 days apart, or 3) received two PGF injections and were inserted with a progesterone releasing intravaginal device (PRID) for 6 days beginning 9 days after the first injection of PGF. Fertility was positively related to plasma progesterone concentations prior to the second PGF injection, but PRID treatment did not improve fertility in cows with low progesterone. Cows in synchronized estrus 2-8 days after the second injection of PGF had higher fertility and better reproductive performance than non-synchronized cows. Experiment 3, conducted in Israel, involved three studies that assessed effect of PRID treatment on: 1) progesterone concentration in ovarian tissue and uterine tissue and fluids, 2) changes in systemic LH and estradiol, and 3) development and function of dominant follicles. Treatment with PRID increased progesterone in uterine tissue and fluid exclusive of effects on systemic concentrations. Low progesterone resulted in persistent follicles that exceeded normal size and produced excessive estrogen. Experiment 4, conducted in the US, evaluated influence of endogenous progesterone on embryo development. Cows were given two injections of PGF 14 days apart and single embryos were recovered 7 days after estrus. Among cyclic cows, there was a linear relationship between progesterone concentration and percentage of cows from which an embryo was recovered. Overall these experiments show that systemic progesterone concentrations affect fertility in high-producing dairy cows through effects on follicular development and embryo survival
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Hagan, Christy R. Progesterone Receptor Scaffolding Function in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2012. http://dx.doi.org/10.21236/ada568199.
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Hagan, Christy. Progesterone Receptor Scaffolding Function in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada601953.
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Horwitz, Kathryn B. Hormone Resistance and Progesterone Receptors in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, July 1999. http://dx.doi.org/10.21236/ada375134.
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Fiskum, Gary. Neuroprotection by Progesterone through Stimulation of Mitochondrial Gene Expression. Fort Belvoir, VA: Defense Technical Information Center, August 2001. http://dx.doi.org/10.21236/ada397719.
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Harrell, Joshua C. Breast Cancer Lymphatic Dissemination - Influence of Estrogen and Progesterone. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada486969.
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Harrell, Joshua C., and Kathryn B. Horwitz. Breast Cancer Lymphatic Dissemination-Influence of Estrogen and Progesterone. Fort Belvoir, VA: Defense Technical Information Center, October 2008. http://dx.doi.org/10.21236/ada501595.
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Clark, Robert R. C-7 Progesterone Analogues and MDR1 in Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 2000. http://dx.doi.org/10.21236/ada406203.
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Fiskum, Gary. Neuroprotection by Progesterone Through Simulation of Mitochondrial Gene Expression. Fort Belvoir, VA: Defense Technical Information Center, August 2002. http://dx.doi.org/10.21236/ada415920.
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Fiskum, Gary. Neuroprotection by Progesterone through Stimulation of Mitochondrial Gene Expression. Fort Belvoir, VA: Defense Technical Information Center, August 2000. http://dx.doi.org/10.21236/ada392823.
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