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1

Ferguson, Deborah Helen. Production of chimeric viral genomes for the analysis of tobraviral symptom determinants. University of Birmingham, 1998.

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2

Eliasson-Selling, Lena. Puberty and oestrous symptoms in gilts with special reference to the relationship with production traits. Sveriges Lantbruksuniversitet, 1991.

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3

Nosachev, Igor', and Dmitriy Romanov. Semiotics of mental illness. General psychopathology. INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1027396.

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The methodology and systematics of the diagnostic process in psychiatry are given, information is given about psychopathological symptoms and dynamics of the main productive and negative syndromes, including addictive, as well as the most significant forms of norm and pathology of personality. The leading features of clinical and psychopathological research in general psychopathology are substantiated. 
 The section "Symptomatology" reveals the psychological and clinical features of the main mental processes. The section "Syndromology" describes the clinical features of the main positive
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4

Jones, Andrew M., and Rowland J. Bright-Thomas. Bronchiectasis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0137.

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Bronchiectasis may be defined clinically as the chronic daily production of copious mucopurulent sputum. Pathologically, the disease is characterized by inflamed, thick-walled, dilated bronchi. Bronchiectasis has many potential underlying causes and associations with other diseases but in individual cases the underlying cause is often unknown. The typical symptom is cough with sputum. Bronchiectasis is a chronic condition; systemic complications are common and include tiredness, malaise, and weight loss. The aim of therapy should be to control symptoms, prevent complications and disease progre
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5

Beach, Steven R. H., Heather M. Foran, Richard E. Heyman, et al. Relational Processes. Edited by Erika Lawrence and Kieran T. Sullivan. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199783267.013.11.

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Efforts to expand and update the description of relational processes in theDiagnostic and Statistical Manual of Mental Disorders(DSM) to enhance its clinical utility began with DSM-IV, but met with limited success. The current effort to revise the description of relational problems has focused on both the DSM-V and theInternational Classification of Diseases(ICD)-11, with an emphasis on (1) documenting a solid empirical foundation for inclusion of relational processes in these diagnostic systems and (2) creating categories and symptom sets that reflect that empirical foundation. In this chapte
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6

Slosar, J. R. The Culture of Excess. ABC-CLIO, LLC, 2009. http://dx.doi.org/10.5040/9798400636127.

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In the wake of the 2008-2009 economic recession, this revealing work offers a psychological explanation of how we as a nation grapple with self-control and how we can develop a new and healthier generation. As J.R. Slosar shows in this urgent, sometimes startling volume, the nation’s fast-and-loose approach to money was in fact a symptom of a more widespread pattern of excessive behavior. In The Culture of Excess: How America Lost Self-Control and Why We Need to Redefine Success, Slosar portrays an America where the drive to succeed and the fear of missing out manifested itself not only in sel
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7

Aloisi, Alessandra. The Power of Distraction. Bloomsbury Publishing Plc, 2023. http://dx.doi.org/10.5040/9781350342972.

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From Pascal to contemporary anxieties about attention, we have constantly been urged to avoid distraction if we want to live and work better. But Alessandra Aloisi argues that we are missing the point.Drawing on a broad range ofEuropean philosophy and literature, this book considers distraction not as an expression of human imperfection, but as a creative, subversive, and aesthetic capability. In contrast to the traditional accounts, from Saint Augustine to Robert Burton, which either associated distraction with sin or considered it as a symptom of melancholy, Aloisi argues that it is often pr
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8

Chan, Kin-Sang, Doris M. W. Tse, and Michael M. K. Sham. Dyspnoea and other respiratory symptoms in palliative care. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0082.

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Dyspnoea is prevalent among palliative care patients with increased severity over time. There are two patterns of dyspnoea-breakthrough dyspnoea and constant dyspnoea-and three separate qualities of dyspnoea-air hunger, work or effort, and tightness. The measurement of dyspnoea includes three domains: sensory-perceptual experience, affective distress, and symptom impact. The management of dyspnoea includes specific disease management, non-pharmacological intervention, pharmacological treatment, and palliative non-invasive ventilation. Cough is prevalent and disturbing in patients with cancer a
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9

Keshav, Satish, and Alexandra Kent. Chronic abdominal pain. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0024.

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Separating chronic and acute abdominal pain is often difficult, and an arbitrary time limit of 4 weeks is often used. However, many chronic conditions (e.g. chronic pancreatitis) can cause relapsing symptoms, which may be acute during each episode. Pain receptors in the abdomen respond to chemical and mechanical stimuli. Stretch is the commonest mechanical stimulus to the viscera, although distension, torsion, and contraction are also sensed. Chemical receptors are stimulated by inflammation and infection, and this stimulation leads to the production of various substances, including serotonin,
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10

Lipman, Jeffrey, and Robert J. Boots. Diagnosis, assessment, and management of tetanus, rabies, and botulism. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0245.

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Tetanus, rabies and botulism are all infections characterized by the production of a neurotoxin, and generally do not give rise to a systemic inflammatory response. Typically tetanus result from the infection of wounds by the ubiquitious soil-borne bacteria Clostridium tetanii, botulism is most commonly due to toxin produced in food contaminated with Clostridium botulinum. Rabies usually results from an animal bite infected with the rabies virus of the Lyssavirus group. Neurological involvement by all three infections is characterized by paralysis and autonomic instability with tetanus also be
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11

Wilson, John W., and Lynn L. Estes. Respiratory Tract Infections. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199797783.003.0067.

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Diagnostic criteria include productive cough, symptoms of upper respiratory infection, and negative findings on chest radiographs. Viral agents are the most common cause; antibiotics are therefore not beneficial.•Viral causes: Influenza, parainfluenza, and other respiratory viruses affect >70% of patients•Less common but potentially antibiotic-responsive infectious agents...
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12

Namerow, Norman S. Multiple Sclerosis and Pain. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0019.

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Pain is one of the most prevalent symptoms in persons with MS, and may also complicate other symptoms due to MS such as fatigue, impaired mobility and sleep disturbances. Thus, diagnosis and treatment of pain has become an increasingly important aspect in MS management. The epidemiology of pain in patients with multiple sclerosis is reviewed in this chapter, and a pain classification is presented. Pain syndromes are also reviewed, and appropriate treatments are described. Neuropathic pain in particular is discussed, including current views on the pathophysiology of pain production. An algorith
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13

Thompson-Brenner, Heather, Melanie Smith, Gayle E. Brooks, Dee Ross Franklin, Hallie Espel-Huynh, and James Boswell. The Renfrew Unified Treatment for Eating Disorders and Comorbidity. Oxford University Press, 2021. http://dx.doi.org/10.1093/med-psych/9780190947002.001.0001.

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This treatment program is designed to address any type of eating disorder along with the other emotional problems that people with eating disorders also commonly experience. Eating disorders are related to emotional functioning in many important ways. The overall goal of this treatment is for clients to become more accepting of their emotions in order to respond to them in more productive ways. Each chapter of this workbook teaches clients the skills to manage their emotions. This workbook was developed to help people who have eating disorders and who are also struggling with intense and diffi
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14

Sedlack, Robert E., Conor G. Loftus, Amy S. Oxentenko, and Thomas R. Viggiano. Gastroenterology. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199755691.003.0210.

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Part 1 reviews the major portions of the gastrointestinal system (esophagus, stomach, small intestine, colon, and pancreas), their function (motility, acid production, enzymatic function, and absorption), and various disorders associated with them (dysmotility, ulceration, malabsorption, inflammation, and dysplasia). Symptoms, diagnostic testing, and treatment of common gastrointestinal conditions, such as gastroesophageal reflux disease, peptic ulcer disease, diarrhea, constipation, inflammatory bowel disease, and pancreatitis, are reviewed.
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15

Granacher, Robert P. Neuropsychiatric Aspects Involving the Elderly and the Law. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199374656.003.0002.

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Neuropsychiatry has generally been concerned with the diagnosis and management of syndromes with productive symptoms (positive symptoms) such as hallucinations, mood changes, and delusions. This chapter focuses on the brain-based forensic issues before the law concerning the neuropsychiatry of the older patient. These include the forensic infinitives of legal cognitive capacity to be competent to be tried, enter a plea, be a witness, consent generally, enter a contract, make a will, resist undue influence, refuse treatment, give informed consent, have general competence, have specific competen
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16

Grundy, Seamus. Pleural effusion. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0019.

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Pleural effusion is a common clinical problem which can present both to primary and secondary care. The process by which fluid accumulates can be divided into transudative or exudative. Transudative effusions occur in the presence of normal pleura and are caused by increased oncotic or hydrostatic pressures. Exudative effusions are associated with abnormal pleura and are caused either by increased pleural fluid production due to local inflammation or infiltration or by decreased fluid removal which is caused by obstruction of the lymphatic drainage system. Patients may be entirely asymptomatic
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17

Langendonk, Janneke G., and Timothy M. Cox. Porphyrias. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199972135.003.0043.

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The porphyrias are disorders caused by overproduction of metabolites involved in heme biosynthesis. The four acute porphyrias— acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), and Doss Porphyria—present with severe abdominal pain, often accompanied by agitation, hypertension, and tachycardia associated with neuropathy and sometimes paralysis. Painful and disabling neurovisceral attacks are due to excess production of the heme precursor ALA (delta-aminolevulinic acid).While 90% of individuals with an inherited defect in heme biosynthesis will never
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18

Boxall, Peter, and Bryan Cheyette. The Future of the Novel. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198749394.003.0035.

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This chapter addresses the future of the novel. It also reflects on the possibility and nature of historical change. The push and pull between the novel as an expressive symptom of an ailing culture, and the novel as the engine for the production of new cultural possibilities, runs through the long history of novelists’ reflections on the future of the novel. From our perspective in the early decades of the twenty-first century, the perception of a watershed triggered by 1973, and a new understanding of the relationship between style, fiction, and knowledge, seems remarkably prescient. Moreove
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19

Persley, Denis, Tony Cooke, and Susan House, eds. Diseases of Vegetable Crops in Australia. CSIRO Publishing, 2010. http://dx.doi.org/10.1071/9780643100435.

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Diseases of Vegetable Crops in Australia provides a diagnostic guide and a key reference for diseases affecting vegetable crops in Australia.
 This is an extensively revised and expanded edition of a previous publication that was a standard reference for the Australian vegetable industry.
 Authors from across Australia provide essential information about the important diseases affecting most vegetable grown across Australia’s diverse horticultural production areas. The book includes an account of the causes of plant diseases and the principles underlying their control. It provides an
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20

Ross, Ellen M. “Liberation Is Coming Soon”. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252038266.003.0002.

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This chapter examines the eighteenth-century Quaker reform Joshua Evans. Evans was an important voice in Quaker antislavery, Indian rights advocacy, and American peace history. He was a critic of the developing capitalist economy. He perceived that people were increasingly implicated in the exploitation and oppression of enslaved people, the poor, Indians, even animals, and the land itself. For Evans, war was the fundamental symptom of humans' alienation from God and the most potent catalyst for the ills afflicting eighteenth-century society. He objected to an interconnected market system that
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21

Wray, Shirley H. Eye Movement Disorders in Clinical Practice. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199921805.001.0001.

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This resource offers comprehensive instruction on the diagnosis and treatment of all varieties of eye movement disorders, and reflects the importance of correlating clinical signs of disorders in the oculomotor system with their neuroanatomic and neurophysiologic architecture. With its focus on signs and symptoms, it advances lesion localization of eye movement disorders as the central clinical concern, and presents a fresh review of bedside examination techniques in the ER, ICU, and walk-in clinic; productive ways of taking a clinical history; sign interpretation; source lesion localization;
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22

Grundy, Seamus. Pleural infection and malignancy. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0143.

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Pleural infection transitions from simple parapneumonic effusion, to complex parapneumonic effusion, to empyema. Primary empyema occurs without an underlying pneumonic process. Pleural infection commonly presents identically to pneumonia with dyspnoea, purulent sputum, and fevers. It may be associated with pleuritic chest pain. Empyema can cause systemic sepsis, leading to cardiovascular instability and multi-organ failure. A malignant pleural effusion arises when malignant cells infiltrate the pleura, resulting in increased production and decreased lymphatic drainage of pleural fluid. Maligna
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23

Allen, Shelley J. Pathophysiology of Alzheimer’s disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198779803.003.0002.

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We now know that the onset of the pathological processes leading to Alzheimer’s disease (AD) may be 15–20 years before symptoms appear. This focuses attention on synaptic changes and the early role of tau, and less on the hallmark amyloid plaques (Aβ‎) and neurofibrillary tau tangles. Sensitive biomarkers to allow early screening will be essential. Familial autosomal AD is the result of mutations in one of three genes (APP, PSEN1, or PSEN2), each directly related to increased Aβ‎, and informs pathological mechanisms in common sporadic cases, but are also subject to influence by many risk genes
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24

Burdick, Katherine E., Luz H. Ospina, Stephen J. Haggarty, and Roy H. Perlis. The Neurobiology and Treatment of Bipolar Disorder. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0020.

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Bipolar disorder (BPD) is a severe mood disorder that often has psychotic features. Its most severe forms are more common and significantly more likely to cause disability than originally thought. Studies of high-risk children have found them to be at increased risk for a variety of symptoms and neurobiological abnormalities. In contrast to schizophrenia, there is no formal prodromal syndrome that has been identified, and cognitive abnormalities do not precede the onset of the disorder. Abnormal sleep and circadian rhythms are prominent and have led to intriguing biological models. Neurobiolog
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25

Bronchitis. Exon Publications, 2024. http://dx.doi.org/10.36255/bronchitis.

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Bronchitis is a detailed guide that explains the causes, symptoms, treatment, and prevention of this common respiratory condition. The article begins by introducing bronchitis and its two main types: acute, which is often caused by infections, and chronic, a long-term condition linked to smoking and environmental irritants. It explores the common symptoms, such as persistent coughing, mucus production, and breathing difficulties, while highlighting the differences between acute and chronic cases. The guide provides insight into how bronchitis is diagnosed through medical history, physical exam
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26

Felberg, Mary A. Mitochondrial Disease and Anesthesia. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0042.

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Mitochondrial disease is a genetically, biochemically, and clinically heterogeneous group of disorders that arise from defects in cellular oxidative phosphorylation, most commonly within the electron transport chain. All mitochondrial diseases involve disruption in energy production; clinical symptoms usually manifest in tissues with high energy demands although all organs may be affected. The extent of disease depends not only on the mitochondrial defect but on the numbers of dysfunctional mitochondria present in each tissue. Despite in vitro evidence that almost every anesthetic agent studie
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Nilipour, Reza. Neurolinguistics. Edited by Anousha Sedighi and Pouneh Shabani-Jadidi. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198736745.013.18.

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This chapter summarizes some first neurolinguistic studies conducted in Persian, using patholinguistic data taken from monolingual and bilingual brain-damaged patients, as well as five first neuroimaging studies in healthy native speakers of Persian. The patholinguistic data are extracted from formal clinical linguistic assessments of a heterogeneous group of brain-damaged patients with different etiologies and brain lesion sites. The data are indicative of general agrammatic features of ‘syntactic simplification’ and ‘morphological regression’ reported in cross-language studies, along with la
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28

Crosson, Bruce A., Anastasia Ford, and Anastasia M. Raymer. Transcortical Motor Aphasia. Edited by Anastasia M. Raymer and Leslie J. Gonzalez Rothi. Oxford University Press, 2015. http://dx.doi.org/10.1093/oxfordhb/9780199772391.013.11.

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The defining symptoms of transcortical motor aphasia (TCMA) are nonfluent verbal output with relatively preserved repetition. Other symptoms, such as naming difficulties, agrammatic output, or even some paraphasias, may occur, but these are not cardinal symptoms defining TCMA and are not necessary for the diagnosis. The core anatomy involved in TCMA is a lesion of the medial frontal cortex, especially the left presupplementary motor area (pre-SMA) and adjacent Brodmann’s area 32; a lesion of the left posterior inferior frontal cortex, especially pars opercularis and ventral lateral premotor co
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29

Sahetya, Sarina. Acute Uncomplicated Bronchitis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0029.

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Acute bronchitis is a respiratory illness characterized predominantly by cough with or without sputum production that lasts for up to 3 weeks in the presence of normal chest radiography. Additional presenting symptoms include rhinorrhea, congestion, sneeze, sore throat, wheezing, low-grade fever, myalgia, and fatigue. Causative organisms include viral and bacterial pathogens. The disease course is characterized by self-limited inflammation of the airways. Chest radiographs should be utilized to distinguish acute bronchitis from pneumonia or interstitial disease. Therapeutic recommendations are
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30

Cooke, Tony, Denis Persley, and Susan House, eds. Diseases of Fruit Crops in Australia. CSIRO Publishing, 2009. http://dx.doi.org/10.1071/9780643098282.

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Diseases of Fruit Crops in Australia is the new standard reference in applied plant pathology in Australia covering important diseases affecting the broad range of fruit and nut crops grown throughout Australia. It is an essential tool for growers, horticulturists, crop consultants, research scientists, plant pathologists, quarantine officers, agribusiness representatives, pest management personnel, educators and students.
 The book is generously illustrated with high quality colour images to help diagnose diseases and explains how to identify and manage each disease, describing the sympt
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31

Cuttle, Lisa. Dermatologic Manifestations of Infectious Disease. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199976805.003.0044.

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Toxic infectious exfoliative conditions include staphylococcal toxic shock syndrome (TSS), streptococcal toxic shock syndrome (STSS), and staphylococcal scalded skin syndrome (SSSS). All three are mediated by bacterial toxin production and are considerations in the differential diagnosis of a febrile, hypotensive patient with a rash. Meningococcemia is potentially fatal and extremely contagious with a short incubation period. Disseminated gonococcal infection (DGI) presents with tenosynovitis, dermatitis, and polyarthralgias without purulent arthritis or with purulent arthritis but without ski
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32

Thornton, Kevin, and Michael Gropper. Diagnosis, assessment, and management of hyperthermic crises. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0247.

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Malignant hyperthermia, the neuroleptic malignant syndrome (NMS), and the serotonin syndrome are the principal disorders associated with life-threatening hyperthermia in the intensive care unit. While each is a clinically unique entity, all can progress to multisystem organ dysfunction with acidosis, shock, and death. MH usually results from exposure to halogenated volatile anaesthetics and/or succinylcholine and symptoms of increased CO2 production and respiratory acidosis progress rapidly without prompt intervention, including the administration of dantrolene. NMS is a syndrome of rigidity a
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33

Neligan, Patrick J., and Clifford S. Deutschman. Pathophysiology and causes of metabolic acidosis in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0255.

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Critical illness is typically characterized by changes in the balance of water and electrolytes in the extracellular space, resulting in the accumulation of anionic compounds that manifests as metabolic acidosis. Metabolic acidosis manifests with tachypnoea, tachycardia, vasodilatation, headache and a variety of other non-specific symptoms and signs. It is caused by a reduction in the strong ion difference (SID) or an increase in weak acid concentration (albumin or phosphate). Increased SID results from hyperchloraemia, haemodilution or accumulation of metabolic by-products. A reduction in SID
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34

Langer, Thomas, and Pietro Caironi. Pathophysiology and therapeutic strategy of respiratory alkalosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0114.

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Respiratory alkalosis is a condition characterized by low partial pressure of carbon dioxide and an associated elevation in arterial pH caused by an imbalance between CO2 production and removal, in favour of the latter. Conditions that cause increased alveolar ventilation, without having a reduction in pH as input stimulus, will cause hypocapnia associated with a variable degree of alkalosis. The major effect of hypocapnia is the increase in pH (alkalosis) and the consequent shift of electrolytes that occurs in relation to it. As a general law, in plasma, anions will increase, while cations wi
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35

Chakera, Aron, William G. Herrington, and Christopher A. O’Callaghan. Disorders of acid–base balance. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0178.

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Normal metabolism results in a net acid production of approximately 1 mmol/kg day−1. Physiological pH is regulated by excretion of this acid load (as carbon dioxide) by the kidneys and the lungs. A series of buffers in the body reduces the effects of metabolic acids on body and urine pH. For acid–base disorders to occur, there must be excessive intake (or loss) of acid (or base) or, alternatively, an inability to excrete acid. For these changes to result in a substantially abnormal pH, the various buffer systems must been overwhelmed. The pH scale is logarithmic, so relatively small changes in
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36

Williams, Gareth. Infrapolitical Passages. Fordham University Press, 2020. http://dx.doi.org/10.5422/fordham/9780823289882.001.0001.

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This book clears a way through some of the dominant political determinations and violent symptoms of contemporary globalization. It considers globalization as a new, and increasingly unmoored, ordering for which modern political theory, including its theories of political subjectivation, has proven largely obsolete. Globalization is the hollowing out and expiration of the political-theological imagination of the modern juridical system of states. In this regard Infrapolitical Passages provides (1) a theory of globalization as a crisis of symbolic organization and (2) a theory of global economi
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37

Mease, Philip. Neurobiology of pain in osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0013.

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Significant advances in our understanding of the neurobiology of pain in osteoarthritis (OA) have occurred in the last decade and are herein summarized. Pain is the predominant symptom of OA and occurs at multiple levels from non-cartilage peripheral tissues to spinal cord, and brain and back. At each level, nerve function is regulated by complex ionic channels, neuropeptide expression, and cytokine and chemokine activity. Previously considered a non-inflammatory condition, it is now recognized that cell proliferation and inflammatory cytokine production occurs in OA synovium, contributing to
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Kelly, Evelyn B. What You Need to Know about Asthma. ABC-CLIO, LLC, 2022. http://dx.doi.org/10.5040/9798216034735.

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While some individuals with asthma consider the condition only a minor nuisance, for others it significantly interferes with daily activities and may even be life-threatening. This book offers readers a broad introduction to this common respiratory issue. Asthma is a respiratory condition marked by spasms, swelling, and excess mucus production in the bronchial passages of the lungs. This triggers coughing, wheezing, chest tightness, and shortness of breath. While asthma can usually be managed with medications and avoidance of certain triggers, it's a serious—potentially deadly—chronic disease.
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