Academic literature on the topic 'Production strategy development'

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Journal articles on the topic "Production strategy development"

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Karimov, K. Kh. "Development Strategy of Uzbekistan: Modernization Versus Innovation?" INTERNATIONAL JOURNAL OF INNOVATION AND ECONOMIC DEVELOPMENT 6, no. 4 (2020): 46–53. http://dx.doi.org/10.18775/ijied.1849-7551-7020.2015.64.2003.

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The article investigates the strategic management tools and economic – organizational mechanisms of the entrepreneurial structures of the Republic of Uzbekistan on the macro level. The research results revealed that for fulfilling the Strategy Actions it’s necessary to redirect the strategy from modernization to innovations, and also economical – organizational mechanisms of the entrepreneurial structures and systems as measures for their sustainable growth and innovative development. In this process transformation is the aim, innovative development is the tool, and effective and sustainable development of business structure and systems is asymptotic equilibrium. On the macro level, an optimal innovative level of business units was identified by formulating a mathematic equation. In the equation, the dependent variable is labour productivity, while independent variables include material and intellectual production factors.
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Свистунов and Vasiliy Svistunov. "HUMAN RESOURCE MANAGEMENT STRATEGY AS COMPONENT OF PRODUCTION ORGANIZATION DEVELOPMENT STRATEGY." Management of the Personnel and Intellectual Resources in Russia 1, no. 2 (September 20, 2012): 33–36. http://dx.doi.org/10.12737/1622.

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During the crisis periods the organizations survive, managed to catch a tendency of changes and quickly to adapt to them, including at the expense of their strategy high-quality development. In this regard within strategic behavior of production organization the practical interest is represented by functions of its strategy. The analysis of domestic organizations strengths and weaknesses testifi es that many of them have personnel services rather made on the organization, but often used ineffi ciently. It gives the grounds to speak about the need to improve the work with organization personnel in conditions of organization strategy development formation and realization.
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Clark, John, and Thomas Lamb. "Build Strategy Development." Journal of Ship Production 12, no. 03 (August 1, 1996): 198–209. http://dx.doi.org/10.5957/jsp.1996.12.3.198.

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The 1985 NSRP Design for Production Manual describes the use of a Build Strategy as a basis for improved shipbuilding performance through front-end involvement of all departments and better communication. A number of U.S. shipbuilders are known to have used the approach. However, the extent of its use and the experience of the users was unknown. To remedy this situation the SP-4 Panel conceived a project to determine:how widely "the Build Strategy approach" was known and used by U.S. shipbuilders, anda suitable Build Strategy framework with examples of its use for two typical ship types. This paper summarizes the performance of the project and briefly describes the findings of the U.S. and foreign shipyard surveys and visits, the required prerequisites for use of a Build Strategy and benefits from its use. It also includes the contents list for the proposed Build Strategy framework.
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Khikmatullaev, Timur. "Strategy And Prospects For Development Of The Automotive Industry Of Uzbekistan." American Journal of Interdisciplinary Innovations and Research 03, no. 06 (June 8, 2021): 141–53. http://dx.doi.org/10.37547/tajiir/volume03issue06-19.

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The automotive industry is one of the most important sectors of the world economy, which also belongs to the most capital-intensive areas of the world economy. Globally, the production of automobiles and components employs about 9 million people, who assemble 67 million vehicles each year, contributing 15% of the world's GDP. In addition, everyone employed at the automobile plant provides jobs for 14 more people in related industries. The automotive industry uses more than 15% of the global production of steel and aluminum, more than 10% of the copper smelter in the world. The industry is also the leading consumer of lead, synthetic and natural rubber (50%, 35% and 75% of global production, respectively). In addition, cars in service use half of the world's oil. Consumers spend up to 15% of their budget on cars every year. At the same time, there is a tendency for most of these indicators to grow.
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Fanni, Alfina Taswirul. "Plywood Production Development Strategy at CV Alaf Denida." International Journal of Review Management Business and Entrepreneurship (RMBE) 1, no. 2 (December 26, 2021): 310–19. http://dx.doi.org/10.37715/rmbe.v1i2.2436.

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CV Alaf Denida is a local wood-processing company located in Babat, Lamongan, East Java. CV Alaf Denida started their business in 2013 focused on fabrication in processing of sengon (albasia) into bare core as main material for blockboard production. The factory located in Desa Dradah Blumbang. Kecamatan Kedungpring, Kabupaten Lamongan. This research aims to make a design production development strategies at CV Alaf Denida by identifying internal and external factor of the company, analyzing alternative strategies of production development and recommending priority strategies which is used by CV Alaf Denida in developing the products. The research metode is a qualitative method with an intrinsic case study approach. The collecting data method used in this research done with observasion process, interview, and documentation. Analysis tools used for analyzing the data are IFE, EFE, SWOT, and QSPM matrix for showing the priority strategies. The validity test of this research using researcher triangulation, method, and resource data.
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Gunawan, Diah Setyorini, Neni Widayaningsih, and Barokatuminalloh Barokatuminalloh. "The Strategy Development of SMEs Metal." JEJAK 10, no. 1 (March 10, 2017): 121–37. http://dx.doi.org/10.15294/jejak.v10i1.9131.

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This research aimed to identify the profile of SMEs metal and to analyze the predictors that differentiate the performance achievement of metalworkers in Pasir Wetan Village, Karanglewas Sub-District, Banyumas Regency using primary data obtained from direct interviews with metalworkers in Pasir Wetan Village, Karanglewas Sub-District, Banyumas Regency. Primary data included the data of net income rate, the amount of labor used, the amount of bank credit received, business duration, education level, and the amount of production. The data were analyzed using descriptive analysis and discriminant analysis. The analysis results indicated that the increase in the amount of production and the amount of labor used were the predictors that differentiate the revenue achievement between superior metalworkers group and non-superior metalworkers group. In addition, the amount of production was the best predictor to differentiate the revenue achievement between superior metalworkers group and non-superiors metalworker group.
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Levin, Richard. "Uneven development in Swaziland: Tibiyo, sugar production and rural development strategy." Geoforum 17, no. 2 (January 1986): 239–50. http://dx.doi.org/10.1016/0016-7185(86)90026-6.

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Mahmudova, Ilhama Mahammadnabi, Vusal Mubariz Guliyev, and Asli Khanhuseyn Kazimova. "DEVELOPMENT STRATEGY AND WEIGHT OF THE NON-OIL SECTOR IN THE ECONOMY OF AZERBAIJAN." Academic Review 2, no. 57 (November 25, 2022): 267–76. http://dx.doi.org/10.32342/2074-5354-2022-2-57-20.

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After the collapse of the USSR, the socialist system collapsed in Azerbaijan, as well as in other allied states. That collapse completely destroyed almost all sectors of the country’s economy, especially the non-oil sector. This means that the period of recession in both the oil and non-oil sectors in the country reached its peak. The stagnation of the country’s economy was felt in many areas. It should be noted that agriculture, tourism, manufacturing, and engineering reached such a decline that the country became dependent on imports in most areas. The transition to economic development after such a tense situation in the country’s economy was remembered by our economists by highlighting three historical stages of the development of Azerbaijani economy in the period after the restoration of independence. The following stages ca be singled out: 1) A period of economic recession, 1991-1994. 2) A period of stability and consistent growth beginning, 1994-2003. 3) A period of dynamic development, 2003- until now. The period from 1991 to 1994 is considered the first period for the economy development. During that period, the political and socio-economic situation in the country became more complicated. According to the statistics provided for this period, during 1991-1994, the gross domestic product (GDP) decreased by 16.5 per cent annually. It is also known that in Azerbaijan, especially in the non-oil sector, a decrease in industrial production by 10% in 1991, 37% in 1992 and 50% in 1993 compared to 1985 was recorded. As a result of the collapse of the USSR, the production areas were almost completely out of order, and as a result, the level of unemployment increased to a high level. Again, referring to the statistics of that period, we can say that in 1991-1995, the monetary income of the population in real terms decreased by 3.3 times, and monetary income per capita decreased on average by 3.6 times. In parallel with this, the wages of the population decreased by 5.7 times. Since the times of the USSR, in agriculture, which has strong production and economic potential for Azerbaijan, the cultivated area of the main crops, the number of livestock has decreased sharply, and the level of production has almost fallen to the state of recession. Comparing 1996 with 1990 on the basis of given statistical data, it can be concluded that in 1996 agricultural production in the Republic decreased by more than 2-3 times. In parallel with this, the tense situation in agriculture also had a negative impact on the processing sector. Based on the calculations, it was found that in 1995, compared with 1993, the production of cereals and legumes decreased by 19.7%, cotton production – by 3.7%, tobacco production – by 74%, vegetable production – by 13%, fruit production – by 6.4%. At the same time, that trend was observed in meat and eggs production. During that period, meat production decreased by 10 thousand tons, egg production – by 128.7 million units. It was found than the processes that took place in Azerbaijan in 1991-1994 led to the fact that the country’s economy, especially the non-oil sector, collapsed on a large scale.
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Khmara, Marina, Olena Grinenko, Sergii Koroied, Daria Koucherets, and Olekdandr Bukhanevych. "Development of global production networks in a global environment." Problems and Perspectives in Management 15, no. 3 (December 7, 2017): 467–77. http://dx.doi.org/10.21511/ppm.15(3-2).2017.14.

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Production systems in the structure of economic systems occupy the most fundamental place and act as both initial and basic subsystem of any economic development. There is a tendency to change the forms of production and the study of these process systems poses a wider aspect of their dynamics analysis. The article tries to prove both theoretically and practically that global production networks are one of the most important factors in the innovative transformation of countries and regions. It is concluded due to global production networks, being the channel for the transfer of global knowledge and technical know-how to regional structures, regions of the former periphery have quickly become developed, innovative regions with a specialization in the sector of highly qualified services, production of high-tech products, and generation of scientific knowledge. For transnational companies global production networks reduce their costs and financial risks by sharing with other companies, as well as global division of labor, an important part of global production.
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KURUSHINA, A. O. "DEVELOPMENT OF AN ENTERPRISE DEVELOPMENT STRATEGY UNDER RESOURCE CONSTRAINTS." EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA 6, no. 12 (2020): 30–37. http://dx.doi.org/10.36871/ek.up.p.r.2020.12.06.005.

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This article examines the development of production and economic relations of the enterprise at the present stage in conditions of limited resources, the classification of resources, identifies several main strategies for the development of the enterprise. In addition, the reasons for the emergence of limited resources are analyzed.
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Dissertations / Theses on the topic "Production strategy development"

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Liu, Wei-Chung. "Development of a strategically driven production facilities management (PFM) framework." Thesis, Cranfield University, 2000. http://dspace.lib.cranfield.ac.uk/handle/1826/3647.

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This thesis presents the results of a programme of research into the development and evaluation of a strategically driven Production Facilities Management (PFM) framework. PFM is the activity of managing production facilities to fully realise the corporate strategic objectives of a manufacturing organisation. Companies with strategies tend to be more successful than companies without them. The concept of manufacturing strategy is an approach to enhance the consistency between the manufacturing function and the direction of the organisation. Consequentially, PFM is the means to ensure these strategic requirements can be fully realised from the facilities management viewpoint. Through the literature review, it was seen that there is a lack of a link between manufacturing strategy and the management of production facilities. From questionnaire surveys and interviews at companies in the manufacturing sector, it was found that the issue of linking facilities management with corporate strategy has been ignored. Therefore, this programme of research not only investigates the context and contents in formulating an appropriate manufacturing strategy in a manufacturing environment but also reviews the most popular methods in relation to maintenance management and performance assessment of the facilities. This programme describes the development of a strategically driven, step-by-step approach that helps a company to capture the strategic requirements of the manufacturing function, measure the performance of existing production facilities and supports the decision-making analysis tasks. The primary contribution of the work presented in this thesis was the development of an implementation framework and an associated implementation workbook which comprise a set of stages and implementation sections that a user can use to carry out the process of capturing the strategic requirements and realise them with support from an appropriate PFM framework and a systematic, step-by-step implementation process.
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Bozkurt, Bahar. "Feeding Strategy Development For Human Growth Hormone Production By Pichhia Pastoris." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614559/index.pdf.

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In this study, recombinant human growth hormone (rhGH) production by Pichia pastoris-Mut+ strain was improved by designing feeding strategies which were applied in the production phase of the bioreactor operations. During the bio-reactor experiments the cell growth, sorbitol and methanol consumptions, recom-binant hGH production, alcohol oxidase (AOX) activity, the by-products protease and organic acid concentrations were followed and analyzed. In this context, in the first part of the study, three bioreactor operations were designed and per-formed. In general, the designed strategies are fundamentally based on simulta-neous feeding of the two substrates starting at t=0 h of the production phase, i.e., batch-wise 50 gL-1sorbitol feeding, together with fed-batch methanol feeding with a specific growth rate of &mu
0=0.03 h-1 or &mu
0=0.04 h-1, and fed-batch sorbitol feeding with a specific growth rate of &mu
0=0.025h-1 which was calculated based on the specific consumption rate qS=0.152 g g-1h-1 of sorbitol. Consequently, sorbitol concentration was kept constant at 50 gL-1 within t=0-15h of the production phase
where, sorbitol feeding was terminated at t=15h. Amongst, in the first strategy (SSM1), methanol was fed to the system with the specific growth rate of &mu
0=0.03 h-1, and the H+ concentration (pH) in the bioreactor was kept constant at pH=5.0. In the second strategy (SSM2), pH was kept constant at 5.5 until t=24h of the induction phase (production phase), thereafter, was reduced to pH= 5.0
where methanol was fed to the bioreactor with the specific growth rate of &mu
0=0.03 h-1. In the third strategy (SSM3), methanol was fed with the specific growth rate of &mu
0=0.04 h-1, and the pH in the bioreactor was kept constant at pH 5.0. The highest rhGH production and cell concentration were achieved in the first strategy SSM1 as CrhGH=640 mg L-1 and CX=105.3 g L-1, and the overall cell and product yields on total substrate were calculated as YX/S =0.21 g g-1 and YCrhGH/S =1.83 mg g-1. In the second part of this study the two-substrates sorbitol and methanol were fed simultaneously in a solution compose of 1.37 mol sorbitol and 6.21 mol methanol in 13.88 mol water, which is named as SM. In this strategy (SM), the two-substrate solution was fed to the medium with the specific growth rate of &mu
0=0.03 h-1 on sorbitol until t=30h
thereafter, only methanol was fed to the bio-reactor with the specific growth rate of &mu
0=0.03 h-1. The highest cell and rhGH concentrations obtained in SM were, respectively, Cx=104.7 g L-1 and CrhGH=124 mg L-1
and the overall cell and product yields on the total substrate were calcu-lated as YX/S=0.21 g g-1 and YCrhGH/S=0.39 mg g-1. Although the highest cell con-centration obtained at SM is close to that of the SSM1, the rhGH concentration obtained at SM is 5.2-fold lower than that of the strategy SSM1.
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Russell, Suzana. "The value of localising production as a strategy for sustainable development." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612822.

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Levent, Hande. "Feeding Strategy Development For Benzaldehyde Lyase Production By Recombinant Escherichia Coli Bl21." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609596/index.pdf.

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This study focuses on the molasses based complex medium design for benzaldehyde lyase production by recombinant E. coli BL21 and development of a feeding strategy based on the designed complex medium. For this purpose, firstly, the effects of molasses were investigated in laboratory scale bioreactors. As E. coli BL21 was not able to utilize sucrose, molasses was pretreated and hydrolyzed to fructose and glucose. Thereafter, effect of pretreated molasses concentration was investigated in the range of 16 to 56 kg m-3 by batch-bioreactor experiments
and the highest cell concentration and benzaldehyde lyase activity were obtained as CX=5.3 kg m-3 and A=1617 U cm-3, respectively, in the medium containing 7.5 kg m-3 glucose and 7.5 kg m-3 fructose. Then, different feeding strategies were developed to produce efficient cells with high concentration and BAL activity. In the first strategy, after 10 hours of batch-cultivation with molasses based medium having 7.5 kg m-3 glucose and 7.5 kg m-3 fructose concentration, based on the airflow rate, pretreated molasses was fed to the system. When air flow rate decreased considerably, fed was given to the system that results in increase in glucose and fructose concentration in the medium to 2.5 kg m-3. At the end of the process, the highest cell concentration obtained was CX=7.4 kg m-3. The maximum activity was reached at 20th hour as A=2360 U cm-3. On the other hand, as air flow variation only demonstrated the absence of glucose not fructose, a second strategy, based on the detection of the fructose and glucose concentrations during the process, was applied. In this strategy when glucose and fructose were depleted, fed was given to the system that results in increase in glucose and fructose concentration in the medium to 2.5 kg m-3
and the highest BAL activity was obtained as 2370 U cm-3 at t= 26 h where the cell concentration was 7.5 kg m-3. At the last strategy, when glucose and fructose were depleted, fed was given to the system that results in increase in CGlucose=1.5 kg m-3 and CFructose=1.5 kg m-3 in the production medium to decrease the accumulation of acetic acid. By this strategy highest cell concentration was obtained as 8.04 kg m-3 at t=24 h and the highest BAL activity was 2315 U cm-3. These strategies could be accepted having the same BAL activity with little distinctions. However, cell concentration of the last one was higher than others and also the lowest amount of carbon source was used. Thus, last one could be chosen as the most favorable strategy.
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Taspinar, Hatice. "Exponential Feeding Strategy Development For Benzaldehyde Lyase Production By Recombinant Escherichia Coli." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612311/index.pdf.

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In this study, the aim was to investigate the effects of exponential feeding strategy on benzaldehyde lyase (BAL) production by recombinant Escherichia coli BL21. For this purpose, the effects of medium components were investigated to optimize the initial medium composition of the fed-batch fermentations. For the batch bioreactor operations, the highest cell concentration and BAL activity were achieved in a media containing 30 g L-1 pretreated molasses, and 5 g L-1 (NH4)2HPO4 as 5.07 g L-1, and 1611 U ml-1 at t=8 h, respectively. Thereafter, in order to increase the cell growth and BAL production while avoiding acetate accumulation, fed-batch bioreactor operations were conducted with exponential feeding at different specific growth rates namely, 0.1 h-1 (mu-0.1), 0.15 h-1 (mu-0.15), and 0.2 h-1 (mu-0.2), and a combined exponential and constant feeding (mu-0.2+) strategy. In the experiments, 9 hours of batch-wise operation with the optimized production medium was followed by a fed-batch operation phase using the pre-determined exponential feeding profiles and for mu-0.2+ operation after 10 hours of exponential feeding as mu-0.2, where the feed rate was kept constant at 21.6 g h-1. Additionally, the plasmid stability was investigated using the feeding method of mu-0.2+ operation with antibiotics in the feed solution, and it was observed that the plasmid was stable. Among the three exponential feeding conditions, the highest cell concentration and BAL activity were determined in
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Shand, Wayne Jon. "What are the institutional implications of co-production as a strategy for development?" Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/what-are-the-institutional-implications-of-coproduction-as-a-strategy-for-development(d7bff04e-967f-445f-9d8d-096e76d7ffdc).html.

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This research investigates the institutional implications of co-production as a strategy for development. The study is located within international debates on global development targets beyond 2015 and how cities of the Global South meet the challenges of urbanisation and informality. With forecasts indicating the continuing growth of urban populations, there is an urgent need to consider how governments, working collaboratively with communities, meet the burgeoning demand for housing and basic services and create the institutions necessary for sustainable urban development. Co-production is examined empirically through an embedded case study with the Zimbabwe Homeless People’s Federation, its partner NGO Dialogue on Shelter Trust and the City of Harare Council. The research traces how co-productive relations have evolved between these stakeholders over the period 1997 to 2013. Co-production is considered as a mediating function that supports the creation of spaces for dialogue and problem-solving in complex urban environments. Drawing on sociological institutional theory, the thesis examines the implications of co-productive working on the discursive representation of people in poverty and the institutionalised practices of the state toward low income communities. The research finds that the organisational and deliberative processes associated with co-production are formative: contributing to the efficacy of low income communities and the state to address housing and basic service needs. The thesis reports firstly that community mobilisation has a significant role in bringing together the financial and human resources needed to contribute to co-production. More importantly mobilisation provides the social infrastructure needed to create agential communities. Secondly, where organised communities are involved in the governance of development projects, there is an enhanced capacity to problem solve, which galvanises state support for progressive policies. Thirdly, the research in Harare identified that processes and practices of co-production stimulate adaptation of institutional arrangements. These gain significance over time as they accumulate to affect discourse, epistemic practice and lead to small scale institutional change. The research confirms the potential significance of co-production for sustainable urban development. For communities, co-production serves to shift their subjectivity within existing institutional configurations; creating the potential to act outside of normatively defined roles. For the state, co-production creates an opportunity to establish spaces of deliberation that provide an infusion of resources and can bolster failing legitimacy. However, evidence from Harare also underlines that co-production is contextually defined and adaptive change is fragile in the face of stronger forces of politics and elite interests.
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Tan, Jun Liang. "Development of a pitch based wake optimisation control strategy to improve total farm power production." Thesis, Uppsala universitet, Institutionen för geovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-304705.

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In this thesis, the effect of pitch based optimisation was explored for a 80 turbine wind farm. Using a modified Jensen wake model and the Particle Swarm Optimisation (PSO) model, a pitch optimisation strategy was created for the dominant turbulence and atmospheric condition for the wind farm. As the wake model was based on the FLORIS model developed by P.M.O Gebraad et. al., the wake and power model was compared with the FLORIS model and a -0.090% difference was found. To determine the dynamic predictive capability of the wake model, measurement values across a 10 minute period for a 19 wind turbine array were used and the wake model under predicted the power production by 17.55%. Despite its poor dynamic predictive capability, the wake model was shown to accurately match the AEP production of the wind farm when compared to a CFD simulation done in FarmFlow and only gave a 3.10% over-prediction. When the optimisation model was applied with 150 iterations and particles, the AEP production of the wind farm increased by 0.1052%, proving that the pitch optimisation method works for the examined wind farm. When the iterations and particles used for the optimisation was increased to 250, the power improvement between optimised results improved by 0.1144% at a 222.5% increase in computational time, suggesting that the solution has yet to fully converge. While the solutions did not fully converge, they converged sufficiently and an increase in iterations gave diminishing results. From the results, the pitch optimisation model was found to give a significant increase in power production, especially in wake intensive wind directions. However, the dynamic predictive capabilities will have be improved upon before the control strategy can be applied to an operational wind farm.
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Price, James Vincent. "Development of a unique feeding strategy for the production of succinate via Escherichia coli fermentations." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1460049.

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Trippner, Dietmar, and Karsten Theis. "Agile PLM Strategy Development - Methods and Success Factors [Präsentationsfolien]." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-214705.

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Aus "Ausgangssituation und Herausforderungen": "Produktionsunternehmen und insbesondere die Automobilindustrie unterliegen einem permanent wachsenden Wettbewerbsdruck. Ursache hierfür sind anhaltende rasante gesellschaftliche, politische, gesetzliche und technologische Veränderungen in einem globalen Markt. Daraus resultieren steigende Anforderungen an die zu entwickelnden und herzustellenden Produkte sowie die hierfür geeigneten Technologien, Prozesse, Organisationen und Qualifikationen der Mitarbeiter. Die dafür notwendige Innovationskraft eines Unternehmens ist für den Erhalt und Ausbau der Wettbewerbsfähigkeit eine Grundvoraussetzung und spielt im globalen Markt eine entscheidende Rolle (Tri, 2003). Die „Digitale Transformation“ ist in diesem Kontext eine der ganz großen Herausforderungen, die die Produktionsunternehmen in den kommenden Jahren meistern müssen. ..."
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Henderson, Douglas Brian. "The Development of a New Cloning Strategy for the Biosynthetic Production of Brush-Forming Poly(Amino Acids)." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/30103.

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The design and discovery of new surface-active polymers that self-assemble on solid substrates to form brush layers will have a major impact on numerous applications. Through recombinant DNA technology, there exists the potential to harness a cell's protein synthesis machinery to produce a brush-forming poly(amino acid) (or PAA) with an exactly specified amino acid sequence, thus controlling the polymer's composition at a level unequaled by conventional organic polymer synthesis. The presented work demonstrates the cloning, expression, purification and characterization of de novo-designed PAA's designed to form brush layers on alumina surfaces. Using conventional recombinant DNA methods, the feasibility of producing a PAA consisting of a poly-glutamate block and a poly-proline block was demonstrated. However, the PAA design was limited by the inherent limitations of conventional cloning techniques. We introduce here the development of a simple and versatile strategy for producing de novo-designed, high molecular weight PAA's using recombinant DNA technology. The basis of this strategy is that small DNA modules encoding for short PAA blocks can be easily inserted directly into a commercially available and unmodified expression vector. The insertions can be made repeatedly until the gene encodes for a polymer of desired molecular weight and composition. Thus, sequential modifications can be made to the PAA without having to re-start the gene assembly process from the beginning, thereby allowing for quick determination of how these changes affect polymer structure and function. The feasibility and simplicity of this method was shown during the production of a PAA, consisting of a long zwitterionic tail block and a short acidic anchor block, designed to form optimal brush layers on alumina surfaces. The success and flexibility of this method indicates that it can be applied for production of de novo-designed polypeptides in general. It is hoped that this method will contribute towards the rapid development of bio-inspired protein-based polymers for a variety of applications. This dissertation also contains research that aimed to use phage display technology to develop a new liposome-based immunoassay against biological toxins. This work was part of a collaboration effort with the U.S. Department of Defense and Luna Innovations.
Ph. D.
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Books on the topic "Production strategy development"

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Watanabe, Mariko. The Disintegration of production: Firm strategy and industrial development in China. Cheltenham, UK: Edward Elgar, 2014.

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Maiti, Asok Kumar. Rural profile: Halting change in mode of production : a study of the comprehensive area development strategy. New Delhi, India: Inter-India Publications, 1987.

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Drysdale, Alec. Agricultural land use change and production practices in Bali: A sustainable development strategy proposal. Yogyakarta, Indonesia: Centre for Environmental Studies, Gajah Mada University, 1992.

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1949-, Abe Etsuo, and Fitzgerald Robert 1959-, eds. The origins of Japanese industrial power: Strategy, institutions, and the development of organisational capability. London, England: F. Cass, 1995.

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Cevelev, Aleksandr. Strategic development of railway transport logistics. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/1194747.

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The monograph is devoted to the methodology of material and technical support of railway transport. According to the types of activities, the nature of the material and technical resources used, technologies, means and management systems, Russian railways belong to the category of high-tech industries that must have high quality and technical level, reliability and technological efficiency in operation. For this reason, the logistics system itself, both in structure and in the algorithm of the functions performed as a whole, needs a serious improvement in the quality of its work. The economic situation in Russia requires a revision of the principles and mechanisms of management based on the corporate model of supply chain management, focused on logistics knowledge. In the difficult economic conditions of the current decade, it is necessary to improve the quality of the supply organization of enterprises and structural divisions of railway transport, directly related to the implementation of the process approach, the advantage of which is a more detailed regulation of management actions and their mutual coordination. In order to increase the efficiency of its activities and develop the management system, Russian Railways is developing a lean production system aimed at further expanding the implementation of the principles of customer orientation, ideology and corporate culture. At the present time, the solution of many issues is impossible without a cybernetic approach to the formulation of problems of material and technical support and logistics analysis of information technologies, to the implementation of the developed algorithms and models of development strategies and concepts for improving the business processes of the production system. The management strategy, or the general plan for the implementation of activities for the management of material resources, is based on a fundamental assessment of the alignment and correlation of forces and factors operating in the economic and political field, taking into account the impact on the specific form of the management strategy. The materials will be useful to the heads and specialists of the directorates of the MTO, CDZs and can be used in the scientific research of bachelors, masters and postgraduates interested in the economics of railway transport and supply logistics.
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M, Laseter Timothy, and Russell Max, eds. Strategic product creation: Deliver customer satisfaction from every level of your company. New York: McGraw-Hill, 2007.

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Gurney, L. A management report on the University of Gezira Farm, Wad Medani, Sudan: An outline of the production, management, and accounting strategy considered appropriate for the efficient development of the University of Gezira farm at Nisheisheba, Wad Medani, Sudan. [Wad Medani, Sudan]: The University, 1986.

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Krepon, Michael. The stability-instability paradox: Nuclear weapons and brinksmanship in South Asia. Washington, D.C: Henry L. Stimson Center, 2001.

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United States. Congress. House. Committee on Science, Space, and Technology. Subcommittee on Investigations and Oversight. Meeting: to consider issuance of a subpoena to the Secretary of Energy to compel production of documents related to the development of the Administration's national energy strategy: Meeting before the Subcommittee on Investigations and Oversight of the Committee on Science, Space, and Technology, U.S. House of Representatives, One Hundred Second Congress, first session, August 1, 1991. Washington: U.S. G.P.O., 1991.

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Kōzō, Yamamura, ed. Asia in Japan's embrace: Building a regional production alliance. Cambridge: Cambridge University Press, 1996.

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Book chapters on the topic "Production strategy development"

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Marimin, Lien Herlina, Andri Aulia, Motohide Umano, Itsuo Hatono, and Hiroyuki Tamura. "Expert system for new product strategy development." In Advances in Production Management Systems, 303–14. Boston, MA: Springer US, 1998. http://dx.doi.org/10.1007/978-0-387-35304-3_27.

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Yoshimura, Koki, and Junzo Watada. "Game-Based Strategy Development for Hotel Yield Management." In Innovative Management in Information and Production, 377–86. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-4857-0_40.

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Ichikohji, Takeyasu. "Utilization of New Technology in Incumbents—Development of Hybrid Products Through Insourcing of 3DCG Production." In A Development Strategy for Hybrid Products, 91–107. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4353-8_6.

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Frouin, Marc. "3DExperiences – Dassault Systèmes Strategy to Support New Processes in Product Development and Early Customer Involvement." In Lecture Notes in Production Engineering, 335–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-30817-8_33.

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Weber, M., F. He, M. Weigold, and E. Abele. "Development of a Temperature Strategy for Motor Spindles with Synchronous Reluctance Drive Using Multiple Linear Regression and Neural Network." In Lecture Notes in Production Engineering, 538–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-62138-7_54.

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Kuzmina, Maria, Oksana Avdeyuk, Catherine Kuzmina, Irina Tarasova, and Alevtina Rayushkina. "Strategy of Development of Regional Infrastructure for Creating Innovative Production Complexes in the Digital Economy." In Digital Future Economic Growth, Social Adaptation, and Technological Perspectives, 31–37. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39797-5_4.

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Mosalev, A. I. "Marketing Framework of the Territory as a Basis for the Development of Tourism Strategy." In Smart Technologies and Innovations in Design for Control of Technological Processes and Objects: Economy and Production, 462–70. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-18553-4_57.

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Liu, Jian, F. S. Jia, Z. X. Lei, W. Chen, Y. B. Li, and L. K. Xu. "Production Decline Characteristics and Development Strategy of Strong Natural Water Drive Reservoir with High Water Cut." In Springer Series in Geomechanics and Geoengineering, 74–85. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-7560-5_7.

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Luczak, Holger, Christopher Schlick, Detlef Herbst, Oliver Thome, Markus Wittmann, and Ling Tian. "Cooperation in Product Development." In Strategic Production Networks, 115–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-540-24812-5_5.

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Barbiroli, Giancarlo. "Strategic Technological Pathways for Sustainable Development." In Clean Production, 121–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-79940-2_3.

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Conference papers on the topic "Production strategy development"

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Mityaev, M., B. Belozerov, and S. Lukin. "Geomechanic Model Reconstruction for the Choice of Development Strategy." In SPE Russian Oil and Gas Exploration & Production Technical Conference and Exhibition. Society of Petroleum Engineers, 2014. http://dx.doi.org/10.2118/171157-ms.

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Herenius, T. A., J. Kuyper, and S. Williams. "Environmental Covenants: A New Strategy Towards Sustainable Development?" In SPE Health, Safety and Environment in Oil and Gas Exploration and Production Conference. Society of Petroleum Engineers, 1994. http://dx.doi.org/10.2118/27119-ms.

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Kini, Sisa, James VanDuker, and Bruce Hayes. "PNG LNG's Community Development Support Strategy." In International Conference on Health, Safety and Environment in Oil and Gas Exploration and Production. Society of Petroleum Engineers, 2012. http://dx.doi.org/10.2118/157844-ms.

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Mityaev, M., B. Belozerov, and S. Lukin. "Geomechanic Model Reconstruction for the Choice of Development Strategy (Russian)." In SPE Russian Oil and Gas Exploration & Production Technical Conference and Exhibition. Society of Petroleum Engineers, 2014. http://dx.doi.org/10.2118/171157-ru.

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Kurashkin, Sergei, Vladislav Dmitriev, Kristina Moiseeva, Alexander Korostelev, and Alexander Stashkevich. "Practical-Oriented Method of Development of Strategy of Development of a Production Enterprise." In 2022 IEEE International IOT, Electronics and Mechatronics Conference (IEMTRONICS). IEEE, 2022. http://dx.doi.org/10.1109/iemtronics55184.2022.9795818.

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Gilliver, R. E., J. O. Methven, and R. Nicholls. "Liverpool Bay Development - Oil Spill Response Strategy and its Realisation." In SPE Health, Safety and Environment in Oil and Gas Exploration and Production Conference. Society of Petroleum Engineers, 1996. http://dx.doi.org/10.2118/35896-ms.

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Bradley, A. S., and J. J. Hartog. "Sustainable Development - Implementation Strategy for a Global Exploration and Production Business." In SPE International Conference on Health, Safety and Environment in Oil and Gas Exploration and Production. Society of Petroleum Engineers, 2000. http://dx.doi.org/10.2118/61106-ms.

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Larina, Tatiana, Nikolai Zavodchikov, Galina Petrova, and Vladimir Shakhov. "Information and analytical support of innovations in agricultural production: Russian experience." In Proceedings of the International Scientific and Practical Conference “Digital agriculture - development strategy” (ISPC 2019). Paris, France: Atlantis Press, 2019. http://dx.doi.org/10.2991/ispc-19.2019.42.

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Jiang, Qi, Daniel Nugent, and Kelli Meyer. "SAGD Development Strategy for Concurrent Production of Two Vertically Stacked Clastic Reservoirs." In Canadian Unconventional Resources Conference. Society of Petroleum Engineers, 2011. http://dx.doi.org/10.2118/149007-ms.

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Stanimirova, Mariya. "THE BLUE GROWTH STRATEGY FOR SUSTAINABLE TERRITORIAL DEVELOPMENT." In AGRIBUSINESS AND RURAL AREAS - ECONOMY, INNOVATION AND GROWTH 2021. University publishing house "Science and Economics", University of Economics - Varna, 2021. http://dx.doi.org/10.36997/ara2021.23.

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In modern-day conditions, sustainable territorial development aims to find additional opportunities for regions to maintain their competitiveness while maximizing the use of available local resources and creating conditions for investment in activities that preserve, maintain and improve the local environment. Activities such as fishing, the production of fishery and aquaculture products; coastal tourism; blue biotechnology fall within the scope of the so-called "blue economy". The Blue growth strategy is focused on the sustainable territorial development of fishing areas by supporting, initiating change and integrating the efforts of all stakeholders to achieve the strategic objectives. The main purpose of this report is to present the results of a survey which examines the attitudes of local business representatives, public administration and academics towards the development of activities in the coastal zone of the Local Fisheries Initiative Group (FLAG) Varna - Beloslav - Aksakovo within the blue economy. On the basis of a future development strategy, strategic areas of development are outlined.
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Reports on the topic "Production strategy development"

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Cohen, Roni, Kevin Crosby, Menahem Edelstein, John Jifon, Beny Aloni, Nurit Katzir, Haim Nerson, and Daniel Leskovar. Grafting as a strategy for disease and stress management in muskmelon production. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7613874.bard.

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The overall objective of this research was to elucidate the horticultural, pathological, physiological and molecular factors impacting melon varieties (scion) grafted onto M. cannonballus resistant melon and squash rootstocks. Specific objectives were- to compare the performance of resistant melon germplasm (grafted and non-grafted) when exposed to M. cannoballus in the Lower Rio Grande valley and the Wintergarden, Texas, and in the Arava valley, Israel; to address inter-species relationships between a Monosporascus resistant melon rootstock and susceptible melon scions in terms of fruit-set, fruit quality and yield; to study the factors which determine the compatibility between the rootstock and the scion in melon; to compare the responses of graft unions of differing compatibilities under disease stress, high temperatures, deficit irrigation, and salinity stress; and to investigate the effect of rootstock on stress related gene expression in the scion. Some revisions were- to include watermelon in the Texas investigations since it is much more economically important to the state, and also to evaluate additional vine decline pathogens Didymella bryoniae and Macrophomina phaseolina. Current strategies for managing vine decline rely heavily on soil fumigation with methyl bromide, but restrictions on its use have increased the need for alternative management strategies. Grafting of commercial melon varieties onto resistant rootstocks with vigorous root systems is an alternative to methyl bromide for Monosporascus root rot/vine decline (MRR/VD) management in melon production. Extensive selection and breeding has already produced potential melon rootstock lines with vigorous root systems and disease resistance. Melons can also be grafted onto Cucurbita spp., providing nonspecific but efficient protection from a wide range of soil-borne diseases and against some abiotic stresses, but compatibility between the scion and the rootstock can be problematic. During the first year experiments to evaluate resistance to the vine decline pathogens Monosporascus cannonballus, Didymella bryoniae, and Macrophomina phaseolina in melon and squash rootstocks proved the efficacy of these grafted plants in improving yield and quality. Sugars and fruit size were better in grafted versus non-grafted plants in both Texas and Israel. Two melons (1207 and 124104) and one pumpkin, Tetsukabuto, were identified as the best candidate rootstocks in Texas field trials, while in Israel, the pumpkin rootstock RS59 performed best. Additionally, three hybrid melon rootstocks demonstrated excellent resistance to both M. cannonballus and D. bryoniae in inoculated tests, suggesting that further screening for fruit quality and yield should be conducted. Experiments with ABA in Uvalde demonstrated a significant increase in drought stress tolerance and concurrent reduction in transplant shock due to reduced transpiration for ‘Caravelle’ plants. In Israel, auxin was implicated in reducing root development and contributing to increased hydrogen peroxide, which may explain incompatibility reactions with some squash rootstocks. However, trellised plants responded favorably to auxin (NAA) application at the time of fruit development. Gene expression analyses in Israel identified several cDNAs which may code for phloem related proteins, cyclins or other factors which impact the graft compatibility. Manipulation of these genes by transformation or traditional breeding may lead to improved rootstock cultivars. Commercial applications of the new melon rootstocks as well as the ABA and TIBA growth regulators have potential to improve the success of grafted melons in both Israel and Texas. The disease resistance, fruit quality and yield data generated by the field trials will help producers in both locations to decide what rootstock/scion combinations will be best.
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Elizur, Abigail, Amir Sagi, Gideon Hulata, Clive Jones, and Wayne Knibb. Improving Crustacean Aquaculture Production Efficiencies through Development of Monosex Populations Using Endocrine and Molecular Manipulations. United States Department of Agriculture, June 2010. http://dx.doi.org/10.32747/2010.7613890.bard.

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Background Most of Australian prawn aquaculture production is based on P. monodon. However, the Australian industry is under intense competition from lower priced overseas imports. The availability of all-female monosex populations, by virtue of their large size and associated premium prize, will offer competitive advantage to the industry which desperately needs to counteract competitors within this market. As for the redclaw production in Israel, although it is at its infancy, the growers realized that the production of males is extremely advantageous and that such management strategy will change the economic assumptions and performances of this aquaculture to attract many more growers. Original objectives (as in original proposal) Investigating the sex inheritance mechanism in the tiger prawn. Identification of genes expressed uniquely in the androgenic gland (AG) of prawns and crayfish. The above genes and/or their products will be used to localize the AG in the prawn and manipulate the AG activity in both species. Production of monosex populations through AG manipulation. In the prawn, production of all-female populations and in the crayfish, all-male populations. Achievements In the crayfish, the AG cDNA library was further screened and a third AG specific transcript, designated Cq-AG3, had been identified. Simultaneously the two AG specific genes, which were previously identified, were further characterized. Tissue specificity of one of those genes, termed Cq-AG2, was demonstrated by northern blot hybridization and RNA in-situ hybridization. Bioinformatics prediction, which suggested a 42 amino acid long signal anchor at the N-terminus of the deduced Cq-AG2, was confirmed by immunolocalization of a recombinant protein. Cq-IAG's functionality was demonstrated by dsRNA in-vivo injections to intersex crayfish. Cq-IAGsilencing induced dramatic sex-related alterations, including male feature feminization, reduced sperm production, extensive testicular apoptosis, induction of the vitellogeningene expression and accumulation of yolk proteins in the ovaries. In the prawn, the AG was identified and a cDNA library was created. The putative P. monodonAG hormone encoding gene (Pm-IAG) was identified, isolated and characterized for time of expression and histological localization. Implantation of the AG into prawn post larvae (PL) and juveniles resulted in phenotypic transformation which included the appearance of appendix masculina and enlarged petasma. The transformation however did not result in sex change or the creation of neo males thus the population genetics stage to be executed with Prof. Hulata did not materialized. Repeated AG implantation is currently being trialed. Major conclusions and Implications, both scientific and agricultural Cq-IAG's involvement in male sexual differentiation had been demonstrated and it is strongly suggested that this gene encodes an AG hormone in this crayfish. A thorough screening of the AG cDNA library shows Cq-IAG is the prominent transcript within the library. However, the identification of two additional transcripts hints that Cq-IAG is not the only gene mediating the AG effects. The successful gene silencing of Cq-IAG, if performed at earlier developmental stages, might accomplish full and functional sex reversal which will enable the production of all-male crayfish populations. Pm-IAG is likely to play a similar role in prawns. It is possible that repeated administration of the AG into prawn will lead to the desired full sex reversal, so that WZ neo males, crossed with WZ females can result in WW females, which will form the basis for monosex all-female population.
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Bennett, Alan B., Arthur Schaffer, and David Granot. Genetic and Biochemical Characterization of Fructose Accumulation: A Strategy to Improve Fruit Quality. United States Department of Agriculture, June 2000. http://dx.doi.org/10.32747/2000.7571353.bard.

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The goal of the research project was to evaluate the potential to genetically modify or engineer carbohydrate metabolism in tomato fruit to enhance levels of fructose, a sugar with nearly twice the sweetness value of other sugars. The specific research objectives to achieve that goal were to: 1. Establish the inheritance of a fructose-accumulating trait identified in F1 hybrids of an inferspecific cross between L. hirsutum XL. esculentum and identify linked molecular markers to facilitate its introgression into tomato cultivars. This objective was completed with the genetic data indicating a single major gene, termed Fgr (Fructose glucose ratio), that controlled the partitioning of hexose in the mature fruit. Molecular markers for the gene, were developed to aid introgression of this gene into cultivated tomato. In addition, a second major gene encoding fructokinase 2 (FK2) was found to be a determinant of the fructose to glucose ratio in fruit. The relationship between FK2 and Fgr is epistatic with a combined synergistic effect of the two hirsutum-derived genes on fructose/glucose ratios. 2. Characterize the metabolic and transport properties responsible for high fructose/glucose ratios in fructose-accumulating genotypes. The effect of both the Fgr and FK2 genes on the developmental accumulation of hexoses was studied in a wide range of genetic backgrounds. In all backgrounds the trait is a developmental one and that the increase in fructose to glucose ratio occurs at the breaker stage of fruit development. The following enzymes were assayed, none of which showed differences between genotypes, at either the breaker or ripe stage: invertase, sucrose synthase, FK1, FK2, hexokinase, PGI and PGM. The lack of effect of the FK2 gene on fructokinase activity is surprising and at present we have no explanation for the phenomenon. However, the hirsutum derived Fgr allele was associated with significantly lower levels of phosphorylated glucose, G1c-1-P and G1c-6-P and concomitantly higher levels of the phosphorylated fructose, Fru-6-P, in both the breaker and ripe stage. This suggests a significant role for the isomerase reaction. 3. Develop and implement molecular genetic strategies for the production of transgenic plants with altered levels of enzymes that potentially control fructose/glucose ratios in fruit. This objective focused on manipulating hexokinase and fructokinase expression in transgenic plants. Two highly divergent cDNA clones (Frk1 and Frk2), encoding fructokinase (EC 2.7.1.4), were isolated from tomato (Lycopersicon esculentum) and a potato fructokinase cDNA clone was obtained from Dr. Howard Davies. Following expression in yeast, each fructokinase was identified to code for one of the tomato or potato fructokinase isoforms Transgenic tomato plants were generated with the fructokinase cDNA clone in both sense and antisense orientations and the effect of the gene on tomato plants is currently being studied.
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Dickman, Martin B., and Oded Yarden. Pathogenicity and Sclerotial Development of Sclerotinia sclerotiorum: Involvement of Oxalic Acid and Chitin Synthesis. United States Department of Agriculture, September 1995. http://dx.doi.org/10.32747/1995.7571357.bard.

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Sclerotinia sclerotiorum (Lib.) de Bary is among the world's most successful and omnivorous fungal plant pathogens. Included in the nearly 400 species of plants reported as hosts to this fungus are canola, alfalfa, soybean, sunflower, dry bean and potato. The general inability to develop resistant germplasm with these economically important crops to this pathogen has focused attention on the need for a more detailed examination of the pathogenic determinants involved in disease development. A mechanistic understanding of the successful strategy(ies) used by S. sclerotiorum in colonizing host plants and their linkage to fungal development may provide targets and/or novel approaches with which to design resistant crop plants. This proposal involved experiments which were successful in generating genetically-engineered plants harboring resistance to S. sclerotiorum, the establishment and improvement of molecular tools for the study of this pathogen and the analysis of the linkage between pathogenicity, sclerotial morphogenesis and two biosynthetic pathways: oxalic acid production and chitin synthesis. The highly collaborative project has improved our understanding of S. sclerotiorum pathogenicity, established reliable molecular techniques to facilitate experimental manipilation and generated transgenic plants which are resistant to this econimically important fungus.
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Fang, Mei Lan, Lupin Battersby, Marianne Cranwell, Heather Cassie, Moya Fox, Philippa Sterlini, Jenna Breckenridge, Alex Gardner, and Thomas Curtin. IKT for Research Stage 3: Proposal Development. University of Dundee, December 2022. http://dx.doi.org/10.20933/100001250.

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In 2020, the University of Dundee initiated the development of an Open Research strategy. As part of this initiative, in February 2021 the University’s Library and Learning Centre together with Open Research Champions from the Schools of Health Sciences and Dentistry, formed an Open Research Working group. To build on the University’s open research policy and infrastructure, the purpose of the group was to facilitate ongoing research and development of best practice approaches for our interdisciplinary environment to make outputs, data and other products of our research publicly available, building on University of Dundee’s Open Research policy and infrastructure. Through informal consultations with academic staff and students, the Open Research Working Group found that: → access and reach of research findings can be amplified through effective knowledge mobilisation, and stakeholder and patient and public involvement; and → there was a need for guidance and resources on how-to implement knowledge mobilisation activities with and for stakeholders throughout the entire research process – from proposal development to project completion. In June 2021, the Open Research working group, in partnership with Simon Fraser University’s Knowledge Mobilization Hub began the development of an Integrated Knowledge Translation (IKT) Toolkit, with funding support from the University of Dundee’s Doctoral Academy and Organisational Professional Development. IKT is an approach to knowledge translation that emphasises working in an engaged and collaborative partnership with stakeholders throughout the research cycle in order to have positive impact. The aim was to co-produce evidence-informed, best practice learning materials on how-to: → maintain ongoing relationships between researchers, community stakeholders and decision-makers in research development and implementation; and → facilitate an integrated, participatory way of knowledge production whereby researchers, practitioners and other knowledge users can collaborate to co-generate new and accessible knowledge that can be utilised in contexts ranging from supporting community development to policy guidance for practice. The IKT Toolkit was informed by a focused evidence review and synthesis of published peerreviewed and grey literature and consists of 8 knowledge briefs and a slide deck co-produced for use in any discipline or sector. Each knowledge brief provides practical guidance and resources to support an IKT process in each of eight key research stages: (i) Partnership Building; (ii) Generating Priorities and Ideas; (iii) Proposal development; (iv) Study Design; (v) Data Collection; (vi) Data Analysis; (vii) Reporting and (viii) Dissemination. The current knowledge brief provides IKT guidance on Research Stage 3: Proposal Development.
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Matita, Mirriam, Ephraim Wadonda Chirwa, David Zingwe, and Jacob Mazalale. Use of Climate-Smart Agriculture Practices and Smallholder Farmer Market Participation in Central Malawi. Institute of Development Studies (IDS), February 2022. http://dx.doi.org/10.19088/apra.2022.003.

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In the past few decades, climate-smart agriculture (CSA) has been promoted to improve food security and raise incomes as a strategy for sustainable agricultural development. The adoption rates among smallholder farmers, particularly in Africa, remain low and have varied in different contexts. We investigated the market participation spill over effects from the adoption of CSA practices in central Malawi. We tested the hypothesis that the extent of the use of CSA practices in the past 10 years can lead to production surpluses that enable smallholder farmers to participate in markets and thereby increase agricultural incomes. The findings suggest, among others, the need to intensify efforts to promote CSA adoption specifically over a longer period for benefits of the technologies to materialise. The adoption of CSA practices over time enhances crop market participation – an important aspect required for production sustainability as well as for transforming agriculture towards greater market orientation among smallholder farmers.
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Dickman, Martin B., and Oded Yarden. Phosphorylative Transduction of Developmental and Pathogenicity-Related Cues in Sclerotinia Sclerotiorum. United States Department of Agriculture, April 2004. http://dx.doi.org/10.32747/2004.7586472.bard.

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Sclerotinia sclerotiorum (Lib.) de Bary is among the world's most successful and omnivorous fungal plant pathogens. Included in the more than 400 species of plants reported as hosts to this fungus are canola, alfalfa, soybean, sunflower, dry bean, and potato. The general inability to develop resistant germplasm with these economically important crops to this pathogen has focused attention on the need for a more detailed examination of the pathogenic determinants involved in disease development. This proposal involved experiments that examined the involvement of protein phosphorylation during morphogenesis (hyphal elongation and sclerotia formation) and pathogenesis (oxalic acid). Data obtained from our laboratories during the course of this project substantiates the fact that kinases and phosphatases are involved and important for these processes. A mechanistic understanding of the successful strategy(ies) used by S . sclerotiorum in infecting and proliferating in host plants and this linkage to fungal development will provide targets and/or novel approaches with which to design resistant crop plants including interference with fungal pathogenic development. The original objectives of this grant included: I. Clone the cyclic AMP-dependent protein kinase A (PKA) catalytic subunit gene from S.sclerotiorum and determine its role in fungal pathogenicity, OA production (OA) and/or morphogenesis (sclerotia formation). II. Clone and characterize the catalytic and regulatory subunits of the protein phosphatase PP2A holoenzyme complex and determine their role in fungal pathogenicity and/or morphogenesis as well as linkage with PKA-regulation of OA production and sclerotia formation. III. Clone and characterize the adenylate cyclase-encoding gene from S . sclerotiorum and detennine its relationship to the PKA/PP2A-regulated pathway. IV. Analyze the expression patterns of the above-mentioned genes and their products during pathogenesis and determine their linkage with infection and fungal growth.
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Alemu, Dawit, and John Thompson. The Emerging Importance of Rice as a Strategic Crop in Ethiopia. Institute of Development Studies (IDS), October 2020. http://dx.doi.org/10.19088/apra.2020.009.

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Rice has become one of the most important agricultural commodities in Ethiopia in line with its increased importance throughout Africa. This paper examines the trends of the importance of rice in the country – covering domestic production, imports, the extent of self-sufficiency and associated efforts. Specifically, the paper presents the challenges and opportunities surrounding rice cultivation, processing and marketing, as well as for the future development of the rice sector in Ethiopia.
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Brice, Jeremy. Investment, power and protein in sub-Saharan Africa. Edited by Tara Garnett. TABLE, October 2022. http://dx.doi.org/10.56661/d8817170.

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The place of protein in sub-Saharan Africa’s food system is changing rapidly, raising complex international development, global health and environmental sustainability issues. Despite substantial growth in the region’s livestock agriculture sector, protein consumption per capita remains low, and high levels of undernourishment persist. Meanwhile sub-Saharan Africa’s population is growing and urbanising rapidly, creating expectations that demand for protein will increase rapidly over the coming decades and triggering calls for further investment in the expansion and intensification of the region’s meat and dairy sector. However, growing disquiet over the environmental impacts of further expansion in livestock numbers, and growing sales of alternative protein products in the Global North, has raised questions about the future place of plant-based, insect and lab-grown proteins in African diets and food systems. This report examines financial investment in protein production in sub-Saharan Africa. It begins from the position that investors play an important role in shaping the development of diets and food systems because they are able to mobilise the financial resources required to develop new protein products, infrastructures and value chains, or to prevent their development by withholding investment. It therefore investigates which actors are financing the production in sub-Saharan Africa of: a) animal proteins such as meat, fish, eggs and dairy products; b) ‘protein crops’ such as beans, pulses and legumes; and c) processed ‘alternative proteins’ derived from plants, insects, microbes or animal cells grown in a tissue culture. Through analysing investment by state, philanthropic and private sector organisations – as well as multilateral financial institutions such as development banks – it aims to establish which protein sources and stages of the value chain are financed by different groups of investors and to explore the values and goals which shape their investment decisions. To this end, the report examines four questions: 1. Who is currently investing in protein production in sub-Saharan Africa? 2. What goals do these investors aim to achieve (or what sort of future do they seek to bring about) through making these investments? 3. Which protein sources and protein production systems do they finance? 4. What theory of change links their investment strategy to these goals? In addressing these questions, this report explores what sorts of protein production and provisioning systems different investor groups might be helping to bring into being in sub-Saharan Africa. It also considers what alternative possibilities might be marginalised due to a lack of investment. It thus seeks to understand whose priorities, preferences and visions for the future of food might be informing the changing place of protein in the region’s diets, economies and food systems.
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Lillehoj, Hyun, Dan Heller, and Mark Jenkins. Cellular and molecular identification of Eimeria Acervulina Merozoite Antigens eliciting protective immunity. United States Department of Agriculture, November 1992. http://dx.doi.org/10.32747/1992.7561056.bard.

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Coccidiosis, ubiquitous diseases of poultry, seriously impair the growth and feed utilization of livestock and poultry. Coccidiosis causes over $600 million annual losses world-wide and no vaccine is currently available. The goal of this study was to investigate the cellular and molecular mechanisms controlling protective immune responses to coccidia parasites in order to develop immunological control strategy against coccidiosis. The major findings of this study were: 1) cell-mediated immunity plays a major role in protection against coccidiosis, 2) when different genetic lines showing different levels of disease susceptibility were compared, higher T-cell response was seen in the strains of chickens showing higher disease resistance, 3) early interferon secretion was observed in more coccidia-resistant chicken strains, 4) both sporozoite and merozoite antigens were able to induce interferon production, and 5) chicken monoclonal antibodies which detect immunogenic coccidia proteins have been developed. This study provided a good background work for future studies toward the development of recombinant coccidial vaccine. Availability of chicken monoclonal antibodies which detect immunogenic coccidia proteins will enhance our ability to identify potential coccidial vaccine antigens.
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